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Figure 5
(a) Superposition of AetF–tryptoline (chain A), AetF–L-Trp (PDB entry 8cje, chain C) and AetF–5-Br-Trp (PDB entry 8cjf, chain A) with selected amino acids shown (same color coding as in Fig. 4[link]; dark green C atoms for AetF–5-Br-Trp, with 5-Br-Trp shown in lighter green). Leu215 and Met216 form polar contacts to tryptoline. Gln500 and Asp516 were found to change their conformation upon substrate binding (Gäfe & Niemann, 2023View full citation). (b) Polar contacts of tryptoline are shown as magenta dotted lines.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 82| Part 7| July 2026| Pages 836-844
https://doi.org/10.1107/S2059798326005954
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