Unusual backfolded binding poses of BAZ2A bromodomain binders

Dalle Vedove, A.; Cazzanelli, G.; D'Agostino, V.G.; Vargas Rosales, P.A.; Caflisch, A.; Lolli, G.

doi:10.1107/S2059798326004596

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 3
(a) Dose–response activity curve for compound 28 as measured in the AlphaScreen competition binding assay. (b) Superposition of compound 28 (green) and BAZ2-ICR (magenta). (c) Superposition of compound 28 (green) and an acetyl-pyrrole-thiazole compound with IC₅₀ = 4.0 µM.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 7| July 2026|

https://doi.org/10.1107/S2059798326004596

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