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Figure 5
Subclassification of heterogeneous CryoSPARC classes. A second round of 2D classification was performed in CryoSPARC on particles from classes 5, 8 and 12 (top), selected from those shown in Fig. 4[link]. The resulting subclasses (bottom) reveal that these averages contain multiple distinct projection orientations that were previously grouped together. Particle numbers for each subclass are indicated below. These observations may reflect latent structural heterogeneity within standard 2D averages.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 82| Part 7| July 2026|
https://doi.org/10.1107/S2059798326004572
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