menuforthcoming articles
The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section D: Structural Biology.
See also Forthcoming articles in all IUCr journals.
research papersDimerization of the relaxase from the Bacillus subtilis conjugative plasmid pLS20 by DNA-induced crossover of the catalytic residue
X-ray structures of the relaxase of the pLS20 plasmid are presented in apo and DNA-bound form. In the apo form, the active site is covered by a lid, whereas the DNA-bound structure reveals a cross-over mechanism, exchanging the active site residues of two protein molecules
research papersresearch papersStructural and biochemical characterization of ligand binding, oxidative modulation, and inhibitory mechanisms of human inorganic pyrophosphatase 1
The structural and biochemical studies of human inorganic pyrophosphatase 1 (hsPPA1) reveal how metal ions, phosphate, redox conditions, substrate binding and active-site residues govern pyrophosphate hydrolysis. These insights elucidate the enzyme's molecular mechanism and provide a basis for the rational development of hsPPA1-targeted anticancer therapies.
addenda and errataresearch papersKiNG, a reversibly photoactivatable green variant of the fluorescent protein mNeonGreen
Crystal structures of the reversibly photoactivatable green fluorescent protein KiNG in its non-photoactivated and photoactivated states, combined with site-directed mutagenesis, show that kindling proceeds through light-driven trans-to-cis chromophore isomerization coupled to a concerted rearrangement of five residues in the chromophore cavity and is not accompanied by any change in chromophore protonation.
research papersStructural investigation suggests elongation factor G1 is the bona fide canonical translation factor for ribosome recycling in mycobacteria
Mycobacterial EF-G1 mediates both ribosome recycling and tRNA translocation, in contrast to mycobacterial EF-G2, which acts as a stress-specific factor.
