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Figure 4 Chemical preparation of 4. Reagents and conditions: (i) 4-fluorophenylmagnesiumbromide, ether, reflux; (ii) H2O2, formic acid; (iii) NdCl3·2LiCl, 1 h and then 2 equivalents PyMgCl·LiCl, 273 K, 8-10 h. |
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Figure 4 Chemical preparation of 4. Reagents and conditions: (i) 4-fluorophenylmagnesiumbromide, ether, reflux; (ii) H2O2, formic acid; (iii) NdCl3·2LiCl, 1 h and then 2 equivalents PyMgCl·LiCl, 273 K, 8-10 h. |