S-2-(Adamant-1-yl)-4-methyl­phenyl N,N-dimethyl­thio­carbamate

Huerta, R.; Castillo, I.; Hernández-Ortega, S.

doi:10.1107/S1600536807066603

organic compounds

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ISSN: 2056-9890

Volume 64| Part 1| January 2008| Page o323

https://doi.org/10.1107/S1600536807066603

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S-2-(Adamant-1-yl)-4-methylphenyl N,N-dimethylthiocarbamate

Raúl Huerta,^a Ivan Castillo ^a ^* and Simón Hernández-Ortega ^a

^aInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, CU, México, DF 04510, Mexico
^*Correspondence e-mail: joseivan@servidor.unam.mx

(Received 18 October 2007; accepted 12 December 2007; online 21 December 2007)

The title compound, C₂₀H₂₇NOS, was obtained from the corresponding O-thiocarbamate. The structure features a C=O bond distance of 1.209 (2) Å and an sp³-hybridized S atom [C—S—C = 101.66 (1)°]. The steric bulk of the 1-adamantyl substituent on the 2-position of the aromatic ring is reflected in the S—C—C—C torsion angle [−7.5 (3)°].

Related literature

For related literature, see: Bennett et al. (1999 ); Allen (2002 ); Bruno et al. (2002 ); Flores-Figueroa et al. (2005 ); Higgs & Carrano (2002 ); Newman & Karnes (1966 ).

Experimental

Crystal data

C₂₀H₂₇NOS
M_r = 329.49
Triclinic, $[P \overline 1]$
a = 6.6161 (7) Å
b = 11.2113 (12) Å
c = 13.2231 (14) Å
α = 101.287 (2)°
β = 103.753 (2)°
γ = 103.025 (2)°
V = 895.40 (16) Å³
Z = 2
Mo Kα radiation
μ = 0.19 mm⁻¹
T = 298 (2) K
0.40 × 0.18 × 0.14 mm

Data collection

Bruker SMART APEX CCD area-detector diffractometer
Absorption correction: none
7346 measured reflections
3147 independent reflections
2231 reflections with I > 2σ(I)
R_int = 0.035

Refinement

R[F² > 2σ(F²)] = 0.047
wR(F²) = 0.120
S = 0.94
3147 reflections
211 parameters
H-atom parameters constrained
Δρ_max = 0.24 e Å⁻³
Δρ_min = −0.20 e Å⁻³

Data collection: SMART (Bruker, 1997 ); cell refinement: SAINT-Plus (Bruker, 1997); data reduction: SAINT-Plus; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997a ); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997a); molecular graphics: SHELXTL (Sheldrick, 1997b ); software used to prepare material for publication: SHELXTL.

Supporting information

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S1600536807066603/gw2030sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536807066603/gw2030Isup2.hkl

checkCIF report

Comment top

Newman–Kwart thermal rearrangement of O-thiocarbamates to the corresponding S-thiocarbamates is a widely used reaction for the preparation of benzenethiols (Newman & Karnes, 1966). The presence of bulky substituents on the 2-position of phenols represents a synthetic challenge in this methodology, and the experimental difficulties have been attributed by our group to the steric congestion around the thiocarbamate moiety (Flores-Figueroa et al., 2005). We herein report the preparation (see Experimental and Scheme) of the title compound S-2-adamant-1-yl-4- methylphenyl N,N-dimethylthiocarbamate (I).

Compound (I) crystallizes in the triclinic space group P-1 by slow evaporation of a concentrated 2-propanol solution. A search of the Cambridge Crystallographic Database (Version 5.19; Allen, 2002) using CONQUEST, Version 1.4; Bruno et al., 2002) revealed that (I) represents one of the very few examples of aromatic S-thiocarbamates with sterically demanding substituents adjacent to the S atom. Its structure, which is depicted with atom numbering scheme in Fig. 1, features a C=O bond length of 1.209 (2) Å, and C—S 1.780 (3) Å (Table 1). The bond lengths and angles of the thiocarbamate group of (I) are comparable to those of related compounds (Higgs & Carrano, 2002, Bennett et al., 1999). The steric congestion around the S-thiocarbamate group is reflected in the torsion angle of -7.5 (3)° between the S—C(aromatic) and the adjacent C(aromatic)- C(orthosubsituent) bond (S—C1—C2—C10).

Molecules of (I) pack in chains on the 100 plane, as shown in Fig. 2. These chains are formed by intermolecular C—H···O interactions between the O atom of one molecule and C8—H8B on an adjacent molecule, with C8···O and H8B···O distances of 3.294 (3) and 2.534 (2) Å, respectively. The C and H atoms are located on one of the NMe₂ groups of a the S-thiocarbamate moiety, and the corresponding C—H···O angle is 136.1 (2)°.

Related literature top

For related literature, see: Bennett et al. (1999); Allen (2002); Bruno et al. (2002); Flores-Figueroa et al. (2005); Higgs & Carrano (2002); Newman & Karnes (1966).

Experimental top

O-2-adamant-1-yl-4-methylphenyl N,N-dimethylthiocarbamate (0.26 g, 0.80 mmol) was heated to 593–603 K for 2 h in a round bottom flask equipped with a teflon stopcock. After cooling to room temperature, the material was disolved in dichloromethane, filtered, and evaporated to dryness (30 ml). The solid obtained was disolved in hot 2-propanol, and upon cooling starting material precipitated. After filtering, the mother liquor yielded yellow crystals of (I) by slow evaporation of the solvent. Yield: 0.06 g (23%); m.p. 407–408 K; IR (CHCl₃) 3011, 2903, 2852, 1710, 1655, 1598, 1451, 1406, 1365, 1261, 1170, 1100, 1066, 1029, 910 cm^-1; ¹H NMR (300 MHz, CDCl₃, TMS internal reference) δ 7.24 (1H, d, ArH), 7.13 (1H, d, ArH), 6.94 (1H, dd, ArH), 3.02 (6H, s, NMe), 2.28 (3H, s, ArMe), 2.12 (6H, s, AdH), 2.02 (3H, s, AdH), 1.69 (6H, s, AdH); EI mass spectrum: m/z 329 (M⁺, 18%).

Structure description top

For related literature, see: Bennett et al. (1999); Allen (2002); Bruno et al. (2002); Flores-Figueroa et al. (2005); Higgs & Carrano (2002); Newman & Karnes (1966).

Computing details top

Data collection: SMART (Bruker, 1997); cell refinement: SMART (Bruker, 1997); data reduction: SAINT-Plus (Bruker, 1997); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997a); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997a); molecular graphics: SHELXTL (Sheldrick, 1997b); software used to prepare material for publication: SHELXTL (Sheldrick, 1997b).

Figures top

	Fig. 1. Molecular structure of (I) with atom numbering scheme. Thermal ellipsoids are shown at the 50% probability level.
	Fig. 2. View of the chains of (I) along the 001 axis.
	Fig. 3. The formation of the title compound.

S-2-(Adamant-1-yl)-4-methylphenyl N,N-dimethylthiocarbamate top

Crystal data top

C₂₀H₂₇NOS	Z = 2
M_r = 329.49	F(000) = 356
Triclinic, P1	D_x = 1.222 Mg m⁻³ D_m = No Mg m⁻³ D_m measured by ?
Hall symbol: -P 1	Melting point = 407–408 K
a = 6.6161 (7) Å	Mo Kα radiation, λ = 0.71073 Å
b = 11.2113 (12) Å	Cell parameters from 3272 reflections
c = 13.2231 (14) Å	θ = 2.8–25.3°
α = 101.287 (2)°	µ = 0.19 mm⁻¹
β = 103.753 (2)°	T = 298 K
γ = 103.025 (2)°	Prism, pale yellow
V = 895.40 (16) Å³	0.40 × 0.18 × 0.14 mm

Data collection top

Bruker SMART APEX CCD area-detector diffractometer	2231 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tube	R_int = 0.035
Graphite monochromator	θ_max = 25.0°, θ_min = 1.6°
Detector resolution: 0.83 pixels mm^-1	h = −7→7
ω scans	k = −13→13
7346 measured reflections	l = −15→15
3147 independent reflections

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.047	Hydrogen site location: inferred from neighbouring sites
wR(F²) = 0.120	H-atom parameters constrained
S = 0.94	w = 1/[σ²(F_o²) + (0.0685P)²] where P = (F_o² + 2F_c²)/3
3147 reflections	(Δ/σ)_max < 0.001
211 parameters	Δρ_max = 0.24 e Å⁻³
0 restraints	Δρ_min = −0.20 e Å⁻³

Crystal data top

C₂₀H₂₇NOS	γ = 103.025 (2)°
M_r = 329.49	V = 895.40 (16) Å³
Triclinic, P1	Z = 2
a = 6.6161 (7) Å	Mo Kα radiation
b = 11.2113 (12) Å	µ = 0.19 mm⁻¹
c = 13.2231 (14) Å	T = 298 K
α = 101.287 (2)°	0.40 × 0.18 × 0.14 mm
β = 103.753 (2)°

Data collection top

Bruker SMART APEX CCD area-detector diffractometer	2231 reflections with I > 2σ(I)
7346 measured reflections	R_int = 0.035
3147 independent reflections

Refinement top

R[F² > 2σ(F²)] = 0.047	0 restraints
wR(F²) = 0.120	H-atom parameters constrained
S = 0.94	Δρ_max = 0.24 e Å⁻³
3147 reflections	Δρ_min = −0.20 e Å⁻³
211 parameters

Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > σ(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. Hydrogen atoms were placed in idealized positions, and the isotropic thermal parameters were assigned the values U_iso = 1.2 times the thermal parameter of the parent atom.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
S	1.02047 (9)	0.84253 (6)	0.64328 (4)	0.0637 (2)
O	0.6891 (3)	0.73897 (17)	0.46508 (13)	0.0809 (5)
N	0.9990 (3)	0.68642 (18)	0.46352 (15)	0.0678 (5)
C1	0.8226 (3)	0.91300 (19)	0.67862 (16)	0.0523 (5)
C2	0.7344 (3)	0.89238 (17)	0.76267 (15)	0.0445 (5)
C3	0.6039 (3)	0.96867 (18)	0.78793 (15)	0.0491 (5)
H3	0.5447	0.9581	0.8439	0.059*
C4	0.5563 (3)	1.05877 (19)	0.73570 (17)	0.0558 (5)
C5	0.6397 (4)	1.0725 (2)	0.65162 (19)	0.0686 (6)
H5	0.6055	1.1298	0.6129	0.082*
C6	0.7731 (4)	1.0025 (2)	0.62444 (18)	0.0677 (6)
H6	0.8319	1.0149	0.5687	0.081*
C7	0.8757 (3)	0.7468 (2)	0.50903 (17)	0.0569 (5)
C8	1.2191 (4)	0.6925 (3)	0.5174 (2)	0.0866 (8)
H8A	1.2896	0.7743	0.5677	0.130*
H8B	1.2961	0.6794	0.4650	0.130*
H8C	1.2184	0.6278	0.5554	0.130*
C9	0.9060 (5)	0.6114 (3)	0.3519 (2)	0.0997 (9)
H9A	0.7529	0.6018	0.3295	0.150*
H9B	0.9300	0.5293	0.3457	0.150*
H9C	0.9739	0.6535	0.3068	0.150*
C10	0.7760 (3)	0.79486 (17)	0.82641 (14)	0.0432 (4)
C11	0.6436 (3)	0.78732 (18)	0.90815 (16)	0.0500 (5)
H11A	0.6802	0.8704	0.9578	0.060*
H11B	0.4900	0.7630	0.8697	0.060*
C12	0.6891 (3)	0.69145 (19)	0.97190 (17)	0.0573 (5)
H12	0.6023	0.6892	1.0225	0.069*
C13	0.6294 (4)	0.56006 (19)	0.89568 (18)	0.0620 (6)
H13A	0.4754	0.5325	0.8575	0.074*
H13B	0.6611	0.4999	0.9364	0.074*
C14	0.7607 (3)	0.56505 (19)	0.81512 (16)	0.0577 (6)
H14	0.7225	0.4807	0.7653	0.069*
C15	1.0029 (4)	0.6065 (2)	0.87625 (18)	0.0619 (6)
H15A	1.0364	0.5449	0.9149	0.074*
H15B	1.0871	0.6105	0.8255	0.074*
C16	1.0633 (3)	0.73657 (19)	0.95584 (16)	0.0551 (5)
H16	1.2181	0.7617	0.9956	0.066*
C17	1.0176 (3)	0.83282 (18)	0.89292 (15)	0.0488 (5)
H17A	1.1075	0.8383	0.8448	0.059*
H17B	1.0553	0.9158	0.9429	0.059*
C18	0.7109 (3)	0.65985 (18)	0.75146 (15)	0.0511 (5)
H18A	0.5569	0.6344	0.7136	0.061*
H18B	0.7894	0.6596	0.6981	0.061*
C19	0.9301 (4)	0.7322 (2)	1.03520 (16)	0.0609 (6)
H19A	0.9680	0.8153	1.0851	0.073*
H19B	0.9606	0.6724	1.0765	0.073*
C20	0.4196 (4)	1.1399 (2)	0.7697 (2)	0.0765 (7)
H20A	0.5108	1.2241	0.8080	0.115*
H20B	0.3458	1.1042	0.8159	0.115*
H20C	0.3148	1.1434	0.7070	0.115*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
S	0.0487 (3)	0.0885 (5)	0.0537 (4)	0.0209 (3)	0.0188 (3)	0.0120 (3)
O	0.0518 (10)	0.1095 (14)	0.0698 (10)	0.0296 (9)	0.0059 (8)	0.0049 (9)
N	0.0541 (11)	0.0814 (13)	0.0627 (12)	0.0224 (9)	0.0183 (10)	0.0021 (10)
C1	0.0471 (12)	0.0579 (13)	0.0518 (12)	0.0150 (10)	0.0138 (10)	0.0152 (10)
C2	0.0359 (10)	0.0484 (11)	0.0438 (10)	0.0103 (8)	0.0082 (8)	0.0066 (9)
C3	0.0452 (11)	0.0514 (12)	0.0477 (11)	0.0136 (9)	0.0118 (9)	0.0092 (9)
C4	0.0535 (12)	0.0515 (13)	0.0551 (13)	0.0165 (10)	0.0059 (10)	0.0085 (10)
C5	0.0780 (16)	0.0654 (15)	0.0669 (15)	0.0287 (13)	0.0137 (13)	0.0276 (12)
C6	0.0729 (15)	0.0761 (16)	0.0634 (14)	0.0218 (13)	0.0281 (12)	0.0290 (13)
C7	0.0478 (13)	0.0665 (14)	0.0544 (13)	0.0119 (10)	0.0168 (11)	0.0141 (11)
C8	0.0637 (16)	0.113 (2)	0.097 (2)	0.0411 (15)	0.0336 (15)	0.0275 (17)
C9	0.098 (2)	0.109 (2)	0.0790 (18)	0.0339 (17)	0.0264 (16)	−0.0097 (16)
C10	0.0382 (10)	0.0461 (11)	0.0444 (10)	0.0123 (8)	0.0124 (8)	0.0092 (9)
C11	0.0463 (11)	0.0502 (12)	0.0549 (12)	0.0156 (9)	0.0189 (10)	0.0101 (10)
C12	0.0628 (14)	0.0587 (13)	0.0575 (13)	0.0175 (10)	0.0284 (11)	0.0181 (11)
C13	0.0646 (14)	0.0538 (13)	0.0668 (14)	0.0121 (11)	0.0201 (12)	0.0187 (11)
C14	0.0672 (14)	0.0426 (12)	0.0574 (13)	0.0161 (10)	0.0153 (11)	0.0034 (10)
C15	0.0680 (14)	0.0621 (14)	0.0652 (14)	0.0336 (11)	0.0209 (12)	0.0197 (11)
C16	0.0473 (11)	0.0620 (13)	0.0521 (12)	0.0191 (10)	0.0061 (10)	0.0128 (10)
C17	0.0427 (11)	0.0510 (12)	0.0471 (11)	0.0115 (9)	0.0111 (9)	0.0052 (9)
C18	0.0463 (11)	0.0534 (12)	0.0470 (11)	0.0118 (9)	0.0104 (9)	0.0052 (9)
C19	0.0755 (15)	0.0596 (14)	0.0483 (12)	0.0231 (11)	0.0146 (11)	0.0159 (10)
C20	0.0871 (17)	0.0680 (16)	0.0764 (16)	0.0414 (13)	0.0149 (14)	0.0122 (13)

Geometric parameters (Å, º) top

S—C1	1.780 (2)	C11—H11A	0.9700
S—C7	1.790 (2)	C11—H11B	0.9700
O—C7	1.209 (2)	C12—C13	1.520 (3)
N—C7	1.345 (3)	C12—C19	1.530 (3)
N—C8	1.441 (3)	C12—H12	0.9800
N—C9	1.454 (3)	C13—C14	1.527 (3)
C1—C6	1.395 (3)	C13—H13A	0.9700
C1—C2	1.406 (3)	C13—H13B	0.9700
C2—C3	1.395 (3)	C14—C18	1.524 (3)
C2—C10	1.539 (3)	C14—C15	1.529 (3)
C3—C4	1.382 (3)	C14—H14	0.9800
C3—H3	0.9300	C15—C16	1.527 (3)
C4—C5	1.373 (3)	C15—H15A	0.9700
C4—C20	1.500 (3)	C15—H15B	0.9700
C5—C6	1.370 (3)	C16—C19	1.523 (3)
C5—H5	0.9300	C16—C17	1.525 (3)
C6—H6	0.9300	C16—H16	0.9800
C8—H8A	0.9600	C17—H17A	0.9700
C8—H8B	0.9600	C17—H17B	0.9700
C8—H8C	0.9600	C18—H18A	0.9700
C9—H9A	0.9600	C18—H18B	0.9700
C9—H9B	0.9600	C19—H19A	0.9700
C9—H9C	0.9600	C19—H19B	0.9700
C10—C18	1.541 (3)	C20—H20A	0.9600
C10—C17	1.545 (2)	C20—H20B	0.9600
C10—C11	1.548 (2)	C20—H20C	0.9600
C11—C12	1.528 (3)

C1—S—C7	101.66 (10)	C13—C12—H12	109.2
C7—N—C8	124.42 (19)	C11—C12—H12	109.2
C7—N—C9	118.09 (19)	C19—C12—H12	109.2
C8—N—C9	117.48 (19)	C12—C13—C14	108.95 (17)
C6—C1—C2	120.18 (19)	C12—C13—H13A	109.9
C6—C1—S	115.61 (16)	C14—C13—H13A	109.9
C2—C1—S	123.90 (15)	C12—C13—H13B	109.9
C3—C2—C1	115.62 (18)	C14—C13—H13B	109.9
C3—C2—C10	120.07 (17)	H13A—C13—H13B	108.3
C1—C2—C10	124.31 (16)	C18—C14—C13	109.78 (17)
C4—C3—C2	124.62 (19)	C18—C14—C15	109.31 (17)
C4—C3—H3	117.7	C13—C14—C15	109.31 (17)
C2—C3—H3	117.7	C18—C14—H14	109.5
C5—C4—C3	117.73 (19)	C13—C14—H14	109.5
C5—C4—C20	120.8 (2)	C15—C14—H14	109.5
C3—C4—C20	121.5 (2)	C16—C15—C14	109.94 (16)
C6—C5—C4	120.4 (2)	C16—C15—H15A	109.7
C6—C5—H5	119.8	C14—C15—H15A	109.7
C4—C5—H5	119.8	C16—C15—H15B	109.7
C5—C6—C1	121.3 (2)	C14—C15—H15B	109.7
C5—C6—H6	119.3	H15A—C15—H15B	108.2
C1—C6—H6	119.3	C19—C16—C17	109.52 (17)
O—C7—N	124.6 (2)	C19—C16—C15	110.29 (18)
O—C7—S	123.20 (17)	C17—C16—C15	108.77 (16)
N—C7—S	112.24 (16)	C19—C16—H16	109.4
N—C8—H8A	109.5	C17—C16—H16	109.4
N—C8—H8B	109.5	C15—C16—H16	109.4
H8A—C8—H8B	109.5	C16—C17—C10	111.20 (15)
N—C8—H8C	109.5	C16—C17—H17A	109.4
H8A—C8—H8C	109.5	C10—C17—H17A	109.4
H8B—C8—H8C	109.5	C16—C17—H17B	109.4
N—C9—H9A	109.5	C10—C17—H17B	109.4
N—C9—H9B	109.5	H17A—C17—H17B	108.0
H9A—C9—H9B	109.5	C14—C18—C10	111.19 (16)
N—C9—H9C	109.5	C14—C18—H18A	109.4
H9A—C9—H9C	109.5	C10—C18—H18A	109.4
H9B—C9—H9C	109.5	C14—C18—H18B	109.4
C2—C10—C18	111.72 (15)	C10—C18—H18B	109.4
C2—C10—C17	110.27 (15)	H18A—C18—H18B	108.0
C18—C10—C17	109.83 (14)	C16—C19—C12	108.76 (16)
C2—C10—C11	112.25 (15)	C16—C19—H19A	109.9
C18—C10—C11	106.19 (15)	C12—C19—H19A	109.9
C17—C10—C11	106.37 (15)	C16—C19—H19B	109.9
C12—C11—C10	111.62 (15)	C12—C19—H19B	109.9
C12—C11—H11A	109.3	H19A—C19—H19B	108.3
C10—C11—H11A	109.3	C4—C20—H20A	109.5
C12—C11—H11B	109.3	C4—C20—H20B	109.5
C10—C11—H11B	109.3	H20A—C20—H20B	109.5
H11A—C11—H11B	108.0	C4—C20—H20C	109.5
C13—C12—C11	110.19 (18)	H20A—C20—H20C	109.5
C13—C12—C19	109.73 (17)	H20B—C20—H20C	109.5
C11—C12—C19	109.23 (16)

C7—S—C1—C6	−69.82 (18)	C2—C10—C11—C12	−179.21 (15)
C7—S—C1—C2	116.52 (17)	C18—C10—C11—C12	58.4 (2)
C6—C1—C2—C3	−1.7 (3)	C17—C10—C11—C12	−58.5 (2)
S—C1—C2—C3	171.68 (14)	C10—C11—C12—C13	−59.9 (2)
C6—C1—C2—C10	179.12 (18)	C10—C11—C12—C19	60.7 (2)
S—C1—C2—C10	−7.5 (3)	C11—C12—C13—C14	58.5 (2)
C1—C2—C3—C4	0.9 (3)	C19—C12—C13—C14	−61.8 (2)
C10—C2—C3—C4	−179.92 (17)	C12—C13—C14—C18	−59.5 (2)
C2—C3—C4—C5	1.3 (3)	C12—C13—C14—C15	60.4 (2)
C2—C3—C4—C20	−178.19 (19)	C18—C14—C15—C16	61.3 (2)
C3—C4—C5—C6	−2.8 (3)	C13—C14—C15—C16	−58.9 (2)
C20—C4—C5—C6	176.8 (2)	C14—C15—C16—C19	58.6 (2)
C4—C5—C6—C1	2.0 (4)	C14—C15—C16—C17	−61.5 (2)
C2—C1—C6—C5	0.4 (3)	C19—C16—C17—C10	−61.6 (2)
S—C1—C6—C5	−173.55 (18)	C15—C16—C17—C10	59.0 (2)
C8—N—C7—O	−177.8 (2)	C2—C10—C17—C16	−179.34 (15)
C9—N—C7—O	3.2 (4)	C18—C10—C17—C16	−55.8 (2)
C8—N—C7—S	2.8 (3)	C11—C10—C17—C16	58.72 (19)
C9—N—C7—S	−176.25 (19)	C13—C14—C18—C10	61.8 (2)
C1—S—C7—O	−1.6 (2)	C15—C14—C18—C10	−58.1 (2)
C1—S—C7—N	177.83 (16)	C2—C10—C18—C14	177.91 (15)
C3—C2—C10—C18	124.16 (18)	C17—C10—C18—C14	55.2 (2)
C1—C2—C10—C18	−56.7 (2)	C11—C10—C18—C14	−59.4 (2)
C3—C2—C10—C17	−113.39 (18)	C17—C16—C19—C12	60.7 (2)
C1—C2—C10—C17	65.7 (2)	C15—C16—C19—C12	−59.0 (2)
C3—C2—C10—C11	5.0 (2)	C13—C12—C19—C16	60.8 (2)
C1—C2—C10—C11	−175.85 (17)	C11—C12—C19—C16	−60.1 (2)

Experimental details

Crystal data
Chemical formula	C₂₀H₂₇NOS
M_r	329.49
Crystal system, space group	Triclinic, P1
Temperature (K)	298
a, b, c (Å)	6.6161 (7), 11.2113 (12), 13.2231 (14)
α, β, γ (°)	101.287 (2), 103.753 (2), 103.025 (2)
V (Å³)	895.40 (16)
Z	2
Radiation type	Mo Kα
µ (mm⁻¹)	0.19
Crystal size (mm)	0.40 × 0.18 × 0.14

Data collection
Diffractometer	Bruker SMART APEX CCD area-detector
Absorption correction	–
No. of measured, independent and observed [I > 2σ(I)] reflections	7346, 3147, 2231
R_int	0.035
(sin θ/λ)_max (Å⁻¹)	0.595

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.047, 0.120, 0.94
No. of reflections	3147
No. of parameters	211
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.24, −0.20

Computer programs: SMART (Bruker, 1997), SAINT-Plus (Bruker, 1997), SHELXS97 (Sheldrick, 1997a), SHELXL97 (Sheldrick, 1997a), SHELXTL (Sheldrick, 1997b).

Selected geometric parameters (Å, º) top

S—C1	1.780 (2)	N—C7	1.345 (3)
S—C7	1.790 (2)	N—C8	1.441 (3)
O—C7	1.209 (2)	N—C9	1.454 (3)

C1—S—C7	101.66 (10)	C2—C1—S	123.90 (15)
C7—N—C8	124.42 (19)	O—C7—N	124.6 (2)
C7—N—C9	118.09 (19)	O—C7—S	123.20 (17)
C8—N—C9	117.48 (19)	N—C7—S	112.24 (16)
C6—C1—S	115.61 (16)

Acknowledgements

IC and RH thank DGAPA–UNAM for financial support (PAPIIT IN216806).

References

Allen, F. H. (2002). Acta Cryst. B58, 380–388. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Bennett, S. M. W., Brown, S. M., Conole, G., Dennis, M. R., Fraser, P. K., Radojevic, S., McPartlin, M., Topping, C. M. & Woodward, W. (1999). J. Chem. Soc. Perkin Trans. 1, pp. 3127–3132. Web of Science CSD CrossRef Google Scholar
Bruker (1997). SMART (Version 5.625) and SAINT-Plus (Version 7.01A). Bruker AXS Inc., Madison, Wisconsin, USA. Google Scholar
Bruno, I. J., Cole, J. C., Edgington, P. R., Kessler, M., Macrae, C. F., McCabe, P., Pearson, J. & Taylor, R. (2002). Acta Cryst. B58, 389–397. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Flores-Figueroa, A., Arista-M, V., Talancón-Sánchez, D. & Castillo, I. (2005). J. Braz. Chem. Soc. 16, 397–403. Web of Science CrossRef CAS Google Scholar
Higgs, T. C. & Carrano, C. J. (2002). Eur. J. Org. Chem. pp. 3632–3645. CrossRef Google Scholar
Newman, M. S. & Karnes, H. A. (1966). J. Org. Chem. 31, 3980–3984. CrossRef CAS Web of Science Google Scholar
Sheldrick, G. M. (1997a). SHELXS97 and SHELXL97. University of Göttingen, Germany. Google Scholar
Sheldrick, G. M. (1997b). SHELXTL. Version 6.10. University of Göttingen, Germany. Google Scholar