organic compounds
(2-Butoxyphenyl)boronic acid
aWarsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
*Correspondence e-mail: marek@ch.pw.edu.pl
The title compound, 2-(CH3CH2CH2CH2O)C6H4B(OH)2, exists as a centrosymmetric hydrogen-bonded dimer. Dimers are linked via C—H⋯π and π–π [with closest C⋯C contact of 3.540 (3) Å] interactions to produce a two-dimensional array.
Related literature
For related literature, see: Rettig & Trotter (1977). For the structures of related ortho-alkoxyarylboronic acids, see: Dabrowski et al. (2006); Serwatowski et al. (2006); Yang et al. (2005).
Experimental
Crystal data
|
Refinement
|
Data collection: CrysAlis CCD (Oxford Diffraction, 2005); cell CrysAlis RED (Oxford Diffraction, 2005); data reduction: CrysAlis RED; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: DIAMOND (Brandenburg, 1999); software used to prepare material for publication: SHELXL97.
Supporting information
10.1107/S1600536808000457/tk2240sup1.cif
contains datablocks I, global. DOI:Structure factors: contains datablock I. DOI: 10.1107/S1600536808000457/tk2240Isup2.hkl
Crystals suitable for the X-ray
were grown by slow evaporation of a solution of the acid (0.2 g) in acetone/water (20 ml, 1:1).All H atoms were located in difference syntheses and refined freely. The range of O—H distances = 0.864 (16) to 0.909 (15) Å and range of C—H distances = 0.954 (11) to 1.030 (10) Å.
Data collection: CrysAlis CCD (Oxford Diffraction, 2005); cell
CrysAlis RED (Oxford Diffraction, 2005); data reduction: CrysAlis RED (Oxford Diffraction, 2005); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: DIAMOND (Brandenburg, 1999); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008).Fig. 1. The molecular structure of (I). Displacement ellipsoids are drawn at the 50% probability level. | |
Fig. 2. The crystal packing in (I) showing hydrogen-bonding, C—H–π and π–π interactions as dashed lines. |
C10H15BO3 | F(000) = 416 |
Mr = 194.03 | Dx = 1.212 Mg m−3 |
Monoclinic, P21/c | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: -P 2ybc | Cell parameters from 7109 reflections |
a = 7.4809 (4) Å | θ = 2.3–30.0° |
b = 15.3510 (7) Å | µ = 0.09 mm−1 |
c = 9.2824 (4) Å | T = 102 K |
β = 94.299 (4)° | Prismatic, colourless |
V = 1062.98 (9) Å3 | 0.74 × 0.47 × 0.32 mm |
Z = 4 |
Kuma KM4 CCD diffractometer | 2419 independent reflections |
Radiation source: fine-focus sealed tube | 1924 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.012 |
Detector resolution: 8.6479 pixels mm-1 | θmax = 27.5°, θmin = 2.7° |
ω scans | h = −9→9 |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2005) | k = −19→19 |
Tmin = 0.92, Tmax = 0.97 | l = −12→11 |
9363 measured reflections |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.032 | All H-atom parameters refined |
wR(F2) = 0.096 | w = 1/[σ2(Fo2) + (0.0603P)2] where P = (Fo2 + 2Fc2)/3 |
S = 1.14 | (Δ/σ)max < 0.001 |
2419 reflections | Δρmax = 0.35 e Å−3 |
188 parameters | Δρmin = −0.16 e Å−3 |
0 restraints | Extinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.015 (3) |
C10H15BO3 | V = 1062.98 (9) Å3 |
Mr = 194.03 | Z = 4 |
Monoclinic, P21/c | Mo Kα radiation |
a = 7.4809 (4) Å | µ = 0.09 mm−1 |
b = 15.3510 (7) Å | T = 102 K |
c = 9.2824 (4) Å | 0.74 × 0.47 × 0.32 mm |
β = 94.299 (4)° |
Kuma KM4 CCD diffractometer | 2419 independent reflections |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2005) | 1924 reflections with I > 2σ(I) |
Tmin = 0.92, Tmax = 0.97 | Rint = 0.012 |
9363 measured reflections |
R[F2 > 2σ(F2)] = 0.032 | 0 restraints |
wR(F2) = 0.096 | All H-atom parameters refined |
S = 1.14 | Δρmax = 0.35 e Å−3 |
2419 reflections | Δρmin = −0.16 e Å−3 |
188 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
C1 | 0.22865 (11) | 0.48929 (6) | 0.46605 (10) | 0.0187 (2) | |
C2 | 0.15354 (11) | 0.42983 (6) | 0.36299 (10) | 0.0181 (2) | |
C3 | 0.12666 (12) | 0.34464 (6) | 0.41017 (11) | 0.0213 (2) | |
C4 | 0.16761 (12) | 0.31891 (6) | 0.55234 (11) | 0.0242 (2) | |
C5 | 0.23872 (12) | 0.37970 (7) | 0.65050 (10) | 0.0244 (2) | |
C6 | 0.27140 (12) | 0.46477 (6) | 0.60865 (10) | 0.0219 (2) | |
C7 | 0.32860 (12) | 0.63751 (6) | 0.51594 (10) | 0.0196 (2) | |
C8 | 0.34388 (13) | 0.72079 (6) | 0.43222 (10) | 0.0205 (2) | |
C9 | 0.42380 (14) | 0.79405 (6) | 0.52702 (11) | 0.0236 (2) | |
C10 | 0.46998 (16) | 0.87395 (7) | 0.44072 (13) | 0.0324 (3) | |
B1 | 0.09189 (13) | 0.45600 (7) | 0.20334 (11) | 0.0189 (2) | |
O1 | 0.25505 (9) | 0.57244 (4) | 0.41655 (7) | 0.02163 (19) | |
O2 | 0.10984 (9) | 0.53922 (4) | 0.15252 (7) | 0.02530 (19) | |
O3 | 0.01624 (9) | 0.39432 (4) | 0.11431 (8) | 0.0266 (2) | |
H2O | 0.157 (2) | 0.5714 (9) | 0.2219 (17) | 0.056 (4)* | |
H3O | −0.0232 (18) | 0.4136 (9) | 0.0250 (16) | 0.055 (4)* | |
H3 | 0.0761 (15) | 0.3037 (7) | 0.3414 (12) | 0.027 (3)* | |
H4 | 0.1452 (14) | 0.2583 (7) | 0.5786 (12) | 0.028 (3)* | |
H5 | 0.2692 (15) | 0.3638 (8) | 0.7519 (13) | 0.034 (3)* | |
H6 | 0.3221 (14) | 0.5074 (7) | 0.6758 (12) | 0.029 (3)* | |
H7A | 0.4484 (14) | 0.6175 (7) | 0.5556 (10) | 0.022 (3)* | |
H7B | 0.2485 (13) | 0.6452 (7) | 0.5943 (11) | 0.019 (2)* | |
H8A | 0.4243 (13) | 0.7100 (6) | 0.3536 (11) | 0.022 (3)* | |
H8B | 0.2185 (14) | 0.7378 (7) | 0.3876 (12) | 0.026 (3)* | |
H9A | 0.5375 (14) | 0.7721 (7) | 0.5801 (12) | 0.027 (3)* | |
H9B | 0.3361 (16) | 0.8101 (7) | 0.5990 (12) | 0.030 (3)* | |
H10A | 0.5591 (18) | 0.8578 (8) | 0.3676 (15) | 0.052 (4)* | |
H10B | 0.3595 (18) | 0.8990 (8) | 0.3852 (14) | 0.045 (3)* | |
H10C | 0.5225 (16) | 0.9206 (8) | 0.5042 (13) | 0.045 (4)* |
U11 | U22 | U33 | U12 | U13 | U23 | |
C1 | 0.0164 (4) | 0.0187 (5) | 0.0210 (5) | 0.0035 (3) | 0.0007 (3) | 0.0005 (4) |
C2 | 0.0152 (4) | 0.0192 (5) | 0.0200 (4) | 0.0025 (3) | 0.0009 (3) | 0.0001 (4) |
C3 | 0.0193 (5) | 0.0195 (5) | 0.0251 (5) | 0.0011 (4) | 0.0010 (4) | −0.0008 (4) |
C4 | 0.0241 (5) | 0.0203 (5) | 0.0284 (5) | 0.0027 (4) | 0.0032 (4) | 0.0056 (4) |
C5 | 0.0242 (5) | 0.0281 (5) | 0.0209 (5) | 0.0060 (4) | 0.0012 (4) | 0.0053 (4) |
C6 | 0.0229 (5) | 0.0233 (5) | 0.0190 (5) | 0.0035 (4) | −0.0016 (4) | −0.0015 (4) |
C7 | 0.0212 (5) | 0.0204 (5) | 0.0167 (4) | 0.0003 (3) | −0.0026 (4) | −0.0041 (4) |
C8 | 0.0223 (5) | 0.0216 (5) | 0.0171 (5) | 0.0011 (4) | −0.0020 (4) | −0.0013 (4) |
C9 | 0.0306 (5) | 0.0193 (5) | 0.0200 (5) | 0.0018 (4) | −0.0031 (4) | −0.0021 (4) |
C10 | 0.0397 (6) | 0.0234 (5) | 0.0332 (6) | −0.0038 (5) | −0.0032 (5) | 0.0012 (5) |
B1 | 0.0179 (5) | 0.0184 (5) | 0.0205 (5) | 0.0009 (4) | 0.0011 (4) | −0.0009 (4) |
O1 | 0.0289 (4) | 0.0173 (4) | 0.0176 (3) | −0.0030 (3) | −0.0047 (3) | −0.0005 (3) |
O2 | 0.0369 (4) | 0.0203 (4) | 0.0176 (4) | −0.0063 (3) | −0.0057 (3) | −0.0002 (3) |
O3 | 0.0363 (4) | 0.0194 (4) | 0.0225 (4) | −0.0020 (3) | −0.0090 (3) | −0.0008 (3) |
C1—O1 | 1.3758 (11) | C7—H7B | 0.983 (10) |
C1—C6 | 1.3902 (13) | C8—C9 | 1.5223 (13) |
C1—C2 | 1.4083 (13) | C8—H8A | 0.994 (10) |
C2—C3 | 1.3984 (13) | C8—H8B | 1.030 (10) |
C2—B1 | 1.5710 (13) | C9—C10 | 1.5189 (14) |
C3—C4 | 1.3895 (13) | C9—H9A | 1.009 (11) |
C3—H3 | 0.954 (11) | C9—H9B | 1.001 (12) |
C4—C5 | 1.3825 (14) | C10—H10A | 1.017 (14) |
C4—H4 | 0.980 (10) | C10—H10B | 1.017 (13) |
C5—C6 | 1.3895 (14) | C10—H10C | 0.990 (13) |
C5—H5 | 0.982 (12) | B1—O3 | 1.3526 (12) |
C6—H6 | 0.962 (12) | B1—O2 | 1.3718 (12) |
C7—O1 | 1.4408 (10) | O2—H2O | 0.864 (16) |
C7—C8 | 1.5050 (13) | O3—H3O | 0.909 (15) |
C7—H7A | 0.992 (10) | ||
O1—C1—C6 | 122.72 (9) | C7—C8—C9 | 111.76 (7) |
O1—C1—C2 | 115.75 (8) | C7—C8—H8A | 108.1 (6) |
C6—C1—C2 | 121.53 (9) | C9—C8—H8A | 108.3 (6) |
C3—C2—C1 | 116.92 (8) | C7—C8—H8B | 108.7 (6) |
C3—C2—B1 | 119.71 (8) | C9—C8—H8B | 110.6 (6) |
C1—C2—B1 | 123.30 (8) | H8A—C8—H8B | 109.3 (8) |
C4—C3—C2 | 122.46 (9) | C10—C9—C8 | 112.75 (8) |
C4—C3—H3 | 119.8 (6) | C10—C9—H9A | 108.1 (6) |
C2—C3—H3 | 117.8 (6) | C8—C9—H9A | 108.4 (6) |
C5—C4—C3 | 118.72 (9) | C10—C9—H9B | 109.8 (6) |
C5—C4—H4 | 122.8 (6) | C8—C9—H9B | 108.6 (6) |
C3—C4—H4 | 118.5 (6) | H9A—C9—H9B | 109.1 (9) |
C4—C5—C6 | 121.15 (9) | C9—C10—H10A | 110.0 (7) |
C4—C5—H5 | 120.9 (7) | C9—C10—H10B | 111.4 (7) |
C6—C5—H5 | 118.0 (7) | H10A—C10—H10B | 107.6 (11) |
C5—C6—C1 | 119.20 (9) | C9—C10—H10C | 111.5 (7) |
C5—C6—H6 | 121.8 (7) | H10A—C10—H10C | 108.8 (10) |
C1—C6—H6 | 119.0 (7) | H10B—C10—H10C | 107.4 (10) |
O1—C7—C8 | 107.37 (7) | O3—B1—O2 | 119.28 (8) |
O1—C7—H7A | 108.3 (6) | O3—B1—C2 | 118.50 (8) |
C8—C7—H7A | 110.7 (6) | O2—B1—C2 | 122.22 (8) |
O1—C7—H7B | 109.4 (6) | C1—O1—C7 | 119.14 (7) |
C8—C7—H7B | 110.7 (6) | B1—O2—H2O | 108.7 (10) |
H7A—C7—H7B | 110.3 (8) | B1—O3—H3O | 114.9 (9) |
O1—C1—C2—C3 | 179.49 (7) | C2—C1—C6—C5 | −0.21 (14) |
C6—C1—C2—C3 | −1.00 (13) | O1—C7—C8—C9 | −179.00 (7) |
O1—C1—C2—B1 | −3.50 (13) | C7—C8—C9—C10 | 170.24 (9) |
C6—C1—C2—B1 | 176.01 (8) | C3—C2—B1—O3 | −1.04 (13) |
C1—C2—C3—C4 | 1.34 (13) | C1—C2—B1—O3 | −177.97 (8) |
B1—C2—C3—C4 | −175.78 (8) | C3—C2—B1—O2 | 177.95 (8) |
C2—C3—C4—C5 | −0.45 (14) | C1—C2—B1—O2 | 1.02 (14) |
C3—C4—C5—C6 | −0.84 (14) | C6—C1—O1—C7 | −0.53 (12) |
C4—C5—C6—C1 | 1.16 (14) | C2—C1—O1—C7 | 178.98 (8) |
O1—C1—C6—C5 | 179.27 (8) | C8—C7—O1—C1 | 179.46 (7) |
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2O···O1 | 0.864 (16) | 1.900 (16) | 2.6547 (9) | 145.1 (13) |
O3—H3O···O2i | 0.909 (15) | 1.870 (15) | 2.7776 (9) | 175.8 (13) |
C7—H7A···C1ii | 0.992 (10) | 2.939 (10) | 3.8346 (12) | 150.7 (8) |
C7—H7A···C2ii | 0.992 (10) | 3.103 (10) | 4.0850 (12) | 170.7 (8) |
C7—H7A···C6ii | 0.992 (10) | 2.965 (10) | 3.6436 (13) | 126.5 (7) |
Symmetry codes: (i) −x, −y+1, −z; (ii) −x+1, −y+1, −z+1. |
Experimental details
Crystal data | |
Chemical formula | C10H15BO3 |
Mr | 194.03 |
Crystal system, space group | Monoclinic, P21/c |
Temperature (K) | 102 |
a, b, c (Å) | 7.4809 (4), 15.3510 (7), 9.2824 (4) |
β (°) | 94.299 (4) |
V (Å3) | 1062.98 (9) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.09 |
Crystal size (mm) | 0.74 × 0.47 × 0.32 |
Data collection | |
Diffractometer | Kuma KM4 CCD diffractometer |
Absorption correction | Multi-scan (CrysAlis RED; Oxford Diffraction, 2005) |
Tmin, Tmax | 0.92, 0.97 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 9363, 2419, 1924 |
Rint | 0.012 |
(sin θ/λ)max (Å−1) | 0.650 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.032, 0.096, 1.14 |
No. of reflections | 2419 |
No. of parameters | 188 |
H-atom treatment | All H-atom parameters refined |
Δρmax, Δρmin (e Å−3) | 0.35, −0.16 |
Computer programs: CrysAlis CCD (Oxford Diffraction, 2005), CrysAlis RED (Oxford Diffraction, 2005), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), DIAMOND (Brandenburg, 1999).
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2O···O1 | 0.864 (16) | 1.900 (16) | 2.6547 (9) | 145.1 (13) |
O3—H3O···O2i | 0.909 (15) | 1.870 (15) | 2.7776 (9) | 175.8 (13) |
C7—H7A···C1ii | 0.992 (10) | 2.939 (10) | 3.8346 (12) | 150.7 (8) |
C7—H7A···C2ii | 0.992 (10) | 3.103 (10) | 4.0850 (12) | 170.7 (8) |
C7—H7A···C6ii | 0.992 (10) | 2.965 (10) | 3.6436 (13) | 126.5 (7) |
Symmetry codes: (i) −x, −y+1, −z; (ii) −x+1, −y+1, −z+1. |
Acknowledgements
The X-ray measurements were undertaken in the Crystallographic Unit of the Physical Chemistry Laboratory at the Chemistry Department of the University of Warsaw. This work was supported by the Warsaw University of Technology and by the Polish Ministry of Science and Higher Education (grant No. N N205 055633). This work was supported by the Aldrich Chemical Company through the donation of chemicals.
References
Brandenburg, K. (1999). DIAMOND. Version 2.1c. Crystal Impact GbR, Bonn, Germany. Google Scholar
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This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
The boronic acid group is known to support supramolecular organization due to intermolecular hydrogen bonding. ortho-Substituents in the aryl ring may significantly influence the structural properties of arylboronic acids. There are a few structures of ortho-alkoxyarylboronic acids available in the literature, i.e. those reported by Yang et al. (2005), Serwatowski et al. (2006) and Dabrowski et al. (2006). We were interested in studying the effect of a longer alkoxy chain on the structural characteristics of the related compound, (I).
The molecular structure of (I) shows the entire molecule to be essentially planar, Fig. 1 & Table 1. The mean planes through the boronic and butoxy groups are approximately co-planar with the aromatic ring. The boronic group has an exo–endo conformation. The endo-oriented OH group forms an intramolecular O—H···O bond with the butoxy-O atom, Table 2. As a result, a nearly planar six-membered ring is formed. This motif has been observed in the structures of related ortho-alkoxyarylboronic acids. Monomeric molecules form hydrogen-bonded centrosymmetric dimers typical of boronic acids (Rettig & Trotter, 1977). The crystal packing in (I) features a parallel arrangement of hydrogen-bonded dimers (Fig. 2). It is stabilized in terms of CH-π interactions between the H7a atom of the butoxy group and the aromatic ring of the adjacent molecule: the distance of H7A from the ring centre is 2.777 (11) Å [symmetry code (ii): 1 - x, 1 - y, 1 - z]. As a result, a centrosymmetric dimeric motif can be distinguished. In addition, weak π–π interactions between a pair of aromatic rings lead to their face-to-face center-to-edge stacking with the shortest contact between two C atoms C1—C1iii = 3.540 (3) Å [symmetry code (iii): -x, 1 - y, 1 - z]. The other two π–π interactions are C1···C2iii = 3.594 (5) Å and C1···C6iii = 3.819 (3) Å. Thus, alternate CH-π and π–π interactions result in formation of a two-dimensional array. In conclusion, the hydrogen-bonded dimeric structure of (I) is typical of boronic acids whereas the unique secondary supramolecular assembly is achieved due to weaker CH-π and π–π interactions.