N-[(3,5-Dimethyl­pyrazol-1-yl)meth­yl]phthalimide

Wang, S.-Q.; Jian, F.-F.; Liu, H.-Q.

doi:10.1107/S160053680802518X

organic compounds

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Volume 64| Part 9| September 2008| Page o1733

doi:10.1107/S160053680802518X

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N-[(3,5-Dimethylpyrazol-1-yl)methyl]phthalimide

Su-Qing Wang,^a Fang-Fang Jian ^b ^* and Huan-Qiang Liu ^c

^aMicroscale Science Institute, Department of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, People's Republic of China, ^bMicroscale Science Institute, Weifang University, Weifang 261061, People's Republic of China, and ^cDepartment of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, People's Republic of China
^*Correspondence e-mail: ffjian2008@163.com

(Received 11 July 2008; accepted 5 August 2008; online 9 August 2008)

The title compound {systematic name: 2-[(3,5-dimenthylpyrazol-1-yl)methyl]isoindole-1,3-dione}, C₁₄H₁₃N₃O₂, was prepared by reaction of N-(bromomethyl)phthalimide and 3,5-dimethylpyrazole in chloroform solution. The molecular structure and packing are stabilized by intramolecular C—H⋯O hydrogen-bonding and C—H⋯π interactions.

Related literature

For related literature, see: Jian et al. (2003 , 2004 ); Barszcz et al. (2004 ).

Experimental

Crystal data

C₁₄H₁₃N₃O₂
M_r = 255.27
Monoclinic, P 2₁ /c
a = 12.285 (2) Å
b = 8.4576 (15) Å
c = 15.6162 (19) Å
β = 127.566 (8)°
V = 1286.1 (3) Å³
Z = 4
Mo Kα radiation
μ = 0.09 mm⁻¹
T = 293 (2) K
0.20 × 0.15 × 0.10 mm

Data collection

Bruker SMART CCD area-detector diffractometer
Absorption correction: none
8080 measured reflections
3090 independent reflections
1464 reflections with I > 2σ(I)
R_int = 0.060

Refinement

R[F² > 2σ(F²)] = 0.056
wR(F²) = 0.178
S = 0.98
3090 reflections
173 parameters
H-atom parameters constrained
Δρ_max = 0.33 e Å⁻³
Δρ_min = −0.21 e Å⁻³

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C6—H6B⋯O1	0.97	2.58	2.917 (3)	101
C11—H11A⋯Cg2ⁱ	0.93	2.96	3.723 (3)	140
Symmetry code: (i) -x+1, -y-1, -z. Cg2 is the centroid of atoms N2,N3,C2–C4.

Data collection: SMART (Bruker, 1997 ); cell refinement: SAINT (Bruker, 1997); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL.

Supporting information

Crystal structure: contains datablocks global, I. DOI: 10.1107/S160053680802518X/at2593sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S160053680802518X/at2593Isup2.hkl

checkCIF report

Comment top

The 3,5-dimethyl pyrazole and its derivatives are of considerable interest as the ligands in many biological systems in which they procvide the potential binding site for metal ions (Barszcz et al., 2004). In our search for new ligands of this type, we have synthesized the title compound (I), and describe its structure here.

In the crystal structure of (I) (Fig. 1), the C═O bond length [1.206 (3) Å), (1.208 (3) Å] and the C—N bond length [1.397 (2) Å), (1.396 (3) Å] (Table 1) are in agreement with those observed before (Jian et al., 2004; Jian et al., 2003). The dihedral angle formed by the ring A (N1/C7/C8/C13/C14) and the ring C (C8–C13) is 1.3 (0)°. The dihedral angles formed by the ring A and ring C with the ring B (N2/N3/C2–C4) are 72.0 (1) and 72.0 (4)°, respectively. There is a C—H···O intramolecular interaction (see table 2). The molecular structure is also stabilized by intermolecular C—H···π interactions (Table 2).

Related literature top

For related literature, see: Jian et al. (2003, 2004); Barszcz et al. (2004).

Experimental top

N-bromomethyl phthalic imidine 7.2 g (0.03 mol) and 3,5-dimethyl pyrazole 2.88 g (0.03 mol) were dissolved in 30 ml chloroform. The solution was cooled to 283 K. Then, 4.4 ml (0.03 mol) triethylamine was added dropwise via cannula into the well stirred solution The reaction mixture was stirred at 283 K for 6 h. Then the solution was continued to stir at room temperature about 17 h. 20 ml water was added into the solution, the organic phase was seperated and dryed with anhydrous potassium carbonate, The colourless organic phase was evaporated. The title compound is afforded in 65% yield. The colourless crystals of suitable for X-ray determination were obtained from anhydrous ethanol at room temperature after two days.

Computing details top

Data collection: SMART (Bruker, 1997); cell refinement: SAINT (Bruker, 1997); data reduction: SAINT (Bruker, 1997); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top

Fig. 1. The molecular structure and atom-labeling scheme for (I), with displacement ellipsoids drawn at the 30% probability level.

2-[(3,5-Dimethylpyrazol-1-yl)methyl]isoindole-1,3-dione top

Crystal data top

C₁₄H₁₃N₃O₂	F(000) = 536
M_r = 255.27	D_x = 1.318 Mg m⁻³
Monoclinic, P2₁/c	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybc	Cell parameters from 1464 reflections
a = 12.285 (2) Å	θ = 2.1–28.2°
b = 8.4576 (15) Å	µ = 0.09 mm⁻¹
c = 15.6162 (19) Å	T = 293 K
β = 127.566 (8)°	Block, yellow
V = 1286.1 (3) Å³	0.20 × 0.15 × 0.10 mm
Z = 4

Data collection top

Bruker SMART CCD area-detector diffractometer	1464 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tube	R_int = 0.060
Graphite monochromator	θ_max = 28.2°, θ_min = 2.1°
ϕ and ω scans	h = −16→13
8080 measured reflections	k = −10→11
3090 independent reflections	l = −19→20

Refinement top

Refinement on F²	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F² > 2σ(F²)] = 0.056	H-atom parameters constrained
wR(F²) = 0.178	w = 1/[σ²(F_o²) + (0.0831P)²] where P = (F_o² + 2F_c²)/3
S = 0.98	(Δ/σ)_max < 0.001
3090 reflections	Δρ_max = 0.33 e Å⁻³
173 parameters	Δρ_min = −0.21 e Å⁻³
0 restraints	Extinction correction: SHELXL97 (Sheldrick, 2008), Fc^*=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.051 (6)

Crystal data top

C₁₄H₁₃N₃O₂	V = 1286.1 (3) Å³
M_r = 255.27	Z = 4
Monoclinic, P2₁/c	Mo Kα radiation
a = 12.285 (2) Å	µ = 0.09 mm⁻¹
b = 8.4576 (15) Å	T = 293 K
c = 15.6162 (19) Å	0.20 × 0.15 × 0.10 mm
β = 127.566 (8)°

Data collection top

Bruker SMART CCD area-detector diffractometer	1464 reflections with I > 2σ(I)
8080 measured reflections	R_int = 0.060
3090 independent reflections

Refinement top

R[F² > 2σ(F²)] = 0.056	0 restraints
wR(F²) = 0.178	H-atom parameters constrained
S = 0.98	Δρ_max = 0.33 e Å⁻³
3090 reflections	Δρ_min = −0.21 e Å⁻³
173 parameters

Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > σ(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
O1	0.66997 (19)	−0.2663 (2)	−0.13413 (14)	0.0613 (6)
O2	0.38437 (19)	−0.1191 (2)	−0.05358 (15)	0.0610 (6)
N1	0.50763 (19)	−0.1704 (2)	−0.11721 (15)	0.0443 (5)
N2	0.3078 (2)	−0.1271 (2)	−0.30016 (15)	0.0481 (6)
N3	0.3112 (2)	−0.2458 (2)	−0.35815 (16)	0.0508 (6)
C1	0.1467 (3)	0.0376 (4)	−0.2904 (2)	0.0729 (9)
H1A	0.2309	0.0833	−0.2297	0.109*
H1B	0.0965	−0.0058	−0.2672	0.109*
H1C	0.0925	0.1178	−0.3439	0.109*
C2	0.1782 (3)	−0.0900 (3)	−0.3378 (2)	0.0520 (7)
C3	0.0937 (3)	−0.1884 (3)	−0.4239 (2)	0.0575 (7)
H3B	−0.0016	−0.1922	−0.4669	0.069*
C4	0.1783 (3)	−0.2813 (3)	−0.4344 (2)	0.0524 (7)
C5	0.1404 (3)	−0.4075 (4)	−0.5153 (2)	0.0737 (9)
H5A	0.2223	−0.4502	−0.5013	0.111*
H5B	0.0833	−0.3632	−0.5867	0.111*
H5C	0.0914	−0.4901	−0.5099	0.111*
C6	0.4354 (2)	−0.0637 (3)	−0.20848 (18)	0.0486 (6)
H6A	0.4176	0.0345	−0.1870	0.058*
H6B	0.4937	−0.0397	−0.2292	0.058*
C7	0.6197 (2)	−0.2631 (3)	−0.0875 (2)	0.0442 (6)
C8	0.6612 (2)	−0.3498 (3)	0.01092 (18)	0.0460 (6)
C9	0.7624 (3)	−0.4605 (3)	0.0711 (2)	0.0611 (8)
H9A	0.8183	−0.4937	0.0531	0.073*
C10	0.7773 (3)	−0.5210 (4)	0.1611 (2)	0.0708 (9)
H10A	0.8446	−0.5966	0.2038	0.085*
C11	0.6954 (3)	−0.4717 (4)	0.1882 (2)	0.0685 (9)
H11A	0.7098	−0.5121	0.2498	0.082*
C12	0.5915 (3)	−0.3625 (3)	0.12510 (19)	0.0561 (7)
H12A	0.5342	−0.3306	0.1420	0.067*
C13	0.5765 (2)	−0.3033 (3)	0.03664 (18)	0.0439 (6)
C14	0.4762 (3)	−0.1880 (3)	−0.04554 (19)	0.0454 (6)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
O1	0.0654 (12)	0.0772 (13)	0.0586 (11)	0.0047 (10)	0.0467 (11)	−0.0022 (9)
O2	0.0650 (12)	0.0651 (12)	0.0718 (12)	0.0080 (10)	0.0515 (11)	0.0043 (10)
N1	0.0474 (12)	0.0503 (12)	0.0403 (11)	0.0032 (10)	0.0294 (10)	0.0019 (9)
N2	0.0492 (12)	0.0535 (13)	0.0422 (11)	0.0021 (10)	0.0282 (10)	0.0022 (10)
N3	0.0583 (14)	0.0535 (13)	0.0446 (12)	0.0000 (11)	0.0333 (12)	−0.0004 (10)
C1	0.0560 (18)	0.082 (2)	0.073 (2)	0.0076 (16)	0.0352 (16)	−0.0100 (17)
C2	0.0488 (15)	0.0574 (16)	0.0486 (14)	0.0033 (13)	0.0290 (13)	0.0018 (13)
C3	0.0465 (15)	0.0656 (18)	0.0539 (16)	0.0002 (14)	0.0272 (14)	−0.0010 (14)
C4	0.0558 (16)	0.0550 (16)	0.0448 (14)	−0.0043 (13)	0.0298 (14)	0.0034 (12)
C5	0.075 (2)	0.075 (2)	0.0697 (18)	−0.0117 (17)	0.0434 (17)	−0.0163 (17)
C6	0.0504 (15)	0.0524 (15)	0.0419 (14)	−0.0034 (12)	0.0276 (13)	−0.0003 (12)
C7	0.0455 (14)	0.0481 (14)	0.0425 (13)	−0.0036 (11)	0.0287 (12)	−0.0064 (11)
C8	0.0428 (14)	0.0493 (15)	0.0407 (13)	−0.0045 (12)	0.0227 (12)	−0.0046 (12)
C9	0.0532 (17)	0.0645 (18)	0.0576 (17)	0.0062 (14)	0.0297 (14)	0.0038 (15)
C10	0.0634 (19)	0.064 (2)	0.0615 (19)	0.0063 (15)	0.0261 (16)	0.0135 (15)
C11	0.078 (2)	0.072 (2)	0.0461 (16)	−0.0097 (17)	0.0329 (16)	0.0050 (15)
C12	0.0666 (18)	0.0576 (17)	0.0447 (14)	−0.0142 (14)	0.0343 (14)	−0.0067 (13)
C13	0.0479 (14)	0.0455 (14)	0.0375 (13)	−0.0073 (11)	0.0256 (12)	−0.0054 (11)
C14	0.0471 (14)	0.0521 (15)	0.0413 (13)	−0.0039 (12)	0.0292 (12)	−0.0051 (12)

Geometric parameters (Å, º) top

O1—O1	0.000 (5)	C5—H5A	0.9600
O1—C7	1.208 (3)	C5—H5B	0.9600
O2—C14	1.206 (3)	C5—H5C	0.9600
N1—C7	1.396 (3)	C6—H6A	0.9700
N1—C14	1.397 (3)	C6—H6B	0.9700
N1—C6	1.446 (3)	C7—O1	1.208 (3)
N2—C2	1.355 (3)	C7—C8	1.485 (3)
N2—N3	1.369 (3)	C8—C9	1.372 (3)
N2—C6	1.435 (3)	C8—C13	1.382 (3)
N3—C4	1.343 (3)	C9—C10	1.399 (4)
C1—C2	1.487 (4)	C9—H9A	0.9300
C1—H1A	0.9600	C10—C11	1.373 (4)
C1—H1B	0.9600	C10—H10A	0.9300
C1—H1C	0.9600	C11—C12	1.385 (4)
C2—C3	1.370 (4)	C11—H11A	0.9300
C3—C4	1.390 (4)	C12—C13	1.372 (3)
C3—H3B	0.9300	C12—H12A	0.9300
C4—C5	1.495 (4)	C13—C14	1.479 (4)

O1—O1—C7	0 (10)	N1—C6—H6A	109.0
C7—N1—C14	111.9 (2)	N2—C6—H6B	109.0
C7—N1—C6	124.48 (19)	N1—C6—H6B	109.0
C14—N1—C6	123.6 (2)	H6A—C6—H6B	107.8
C2—N2—N3	112.6 (2)	O1—C7—O1	0.00 (8)
C2—N2—C6	128.8 (2)	O1—C7—N1	125.1 (2)
N3—N2—C6	118.6 (2)	O1—C7—N1	125.1 (2)
C4—N3—N2	103.8 (2)	O1—C7—C8	129.3 (2)
C2—C1—H1A	109.5	O1—C7—C8	129.3 (2)
C2—C1—H1B	109.5	N1—C7—C8	105.5 (2)
H1A—C1—H1B	109.5	C9—C8—C13	121.6 (2)
C2—C1—H1C	109.5	C9—C8—C7	129.9 (2)
H1A—C1—H1C	109.5	C13—C8—C7	108.5 (2)
H1B—C1—H1C	109.5	C8—C9—C10	116.5 (3)
N2—C2—C3	105.8 (2)	C8—C9—H9A	121.7
N2—C2—C1	123.1 (2)	C10—C9—H9A	121.7
C3—C2—C1	131.1 (2)	C11—C10—C9	121.8 (3)
C2—C3—C4	106.6 (2)	C11—C10—H10A	119.1
C2—C3—H3B	126.7	C9—C10—H10A	119.1
C4—C3—H3B	126.7	C10—C11—C12	120.9 (3)
N3—C4—C3	111.2 (2)	C10—C11—H11A	119.5
N3—C4—C5	119.5 (2)	C12—C11—H11A	119.5
C3—C4—C5	129.3 (2)	C13—C12—C11	117.4 (3)
C4—C5—H5A	109.5	C13—C12—H12A	121.3
C4—C5—H5B	109.5	C11—C12—H12A	121.3
H5A—C5—H5B	109.5	C12—C13—C8	121.7 (3)
C4—C5—H5C	109.5	C12—C13—C14	130.1 (2)
H5A—C5—H5C	109.5	C8—C13—C14	108.2 (2)
H5B—C5—H5C	109.5	O2—C14—N1	124.3 (2)
N2—C6—N1	112.99 (19)	O2—C14—C13	129.8 (2)
N2—C6—H6A	109.0	N1—C14—C13	105.9 (2)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C6—H6B···O1	0.97	2.58	2.917 (3)	101
C11—H11A···Cg2ⁱ	0.93	2.96	3.723 (3)	140

Symmetry code: (i) −x+1, −y−1, −z.

Experimental details

Crystal data
Chemical formula	C₁₄H₁₃N₃O₂
M_r	255.27
Crystal system, space group	Monoclinic, P2₁/c
Temperature (K)	293
a, b, c (Å)	12.285 (2), 8.4576 (15), 15.6162 (19)
β (°)	127.566 (8)
V (Å³)	1286.1 (3)
Z	4
Radiation type	Mo Kα
µ (mm⁻¹)	0.09
Crystal size (mm)	0.20 × 0.15 × 0.10

Data collection
Diffractometer	Bruker SMART CCD area-detector diffractometer
Absorption correction	–
No. of measured, independent and observed [I > 2σ(I)] reflections	8080, 3090, 1464
R_int	0.060
(sin θ/λ)_max (Å⁻¹)	0.665

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.056, 0.178, 0.98
No. of reflections	3090
No. of parameters	173
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.33, −0.21

Computer programs: SMART (Bruker, 1997), SAINT (Bruker, 1997), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), SHELXTL (Sheldrick, 2008).

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C6—H6B···O1	0.97	2.58	2.917 (3)	100.6
C11—H11A···Cg2ⁱ	0.93	2.96	3.723 (3)	140

Symmetry code: (i) −x+1, −y−1, −z.

References

Barszcz, B., Glowiak, T., Jezierska, J. & Tomkiewicz, A. (2004). Polyhedron, 23, 1309–1316. Web of Science CSD CrossRef CAS Google Scholar
Bruker (1997). SMART and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA. Google Scholar
Jian, F. F., Li, Y., Xiao, H. L. & Sun, P. P. (2003). Struct. Chem. 22, 687–690. CAS Google Scholar
Jian, F.-F., Xiao, H.-L., Qin, Y.-Q. & Xu, L.-Z. (2004). Acta Cryst. C60, o492–o493. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. Web of Science CrossRef CAS IUCr Journals Google Scholar

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doi:10.1107/S160053680802518X

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