Issue contents
Download PDF of article
Download CIF
3D view
Navigation
Highlighting
Dictionary of Crystallography reference
IUPAC Gold Book reference
more ...
Download citation
FormatBIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Plain Text
share
Previous article
Next article
Previous article
Issue contents
Download PDF of article
Download CIF
3D view
Navigation
Highlighting
Dictionary of Crystallography reference
IUPAC Gold Book reference
more ...
Download citation
FormatBIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Plain Text
share
Next article

organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 64| Part 9| September 2008| Page o1732
doi:10.1107/S1600536808025002

(2S,3S)-3-(4-Chloro­phen­yl)-8-methyl­tropane-2-carboxylic acid

Zheng-Ping Chen,a Song-Pei Wang,a Xiao-Min Li,a Jie Tanga and Jian-Guo Lina*

aThe Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, People's Republic of China
*Correspondence e-mail: jglin@yahoo.cn

(Received 16 July 2008; accepted 4 August 2008; online 9 August 2008)

In the title compound, C15H18ClNO2, the inter­nal torsion angles of the tropane ring are comparable to those of tropane rings in the crystal structures reported for cocaine and its derivatives. There is an intra­molecular hydrogen bond between the N atom in the tropane ring and the O atom of the carboxyl group. The crystal structure is further stabilized by many weak C—H⋯O inter­actions between the mol­ecules in the ab plane, forming a two-dimensional supra­molecular network.

Related literature

For general background, see: Clarke et al. (1973[Clarke, R. L., Daum, S. J., Gambino, A. J., Aceto, M. D., Pearl, J., Levitt, M., Cumiskey, W. R. & Bogado, E. F. (1973). J. Med. Chem. 16, 1260-1267.]); Carroll et al. (1991[Carroll, F. I., Gao, Y. G., Rahman, M. A., Abraham, P., Parham, K., Lewin, A. H., Boja, J. W. & Kuhart, M. J. (1991). J. Med. Chem. 34, 2719-2725.], 2005[Carroll, F. I., Tyagi, S., Blough, B. E., Kuhar, M. J. & Navarro, H. A. (2005). J. Med. Chem. 48, 3852-3857.]). For related structures, see: Meltzer et al. (1997[Meltzer, P. C., Liang, A. Y., Blundell, P., Gonzalez, M. D., Chen, Z. M. & Madras, B. K. (1997). J. Med. Chem. 40, 2661-2673.], 2001[Meltzer, P. C., Wang, B., Chen, Z. M., Blundell, P., Jayaraman, M., Gonzalez, M. D., George, C. & Madras, B. K. (2001). J. Med. Chem. 44, 2619-2635.]); Zhu et al. (1999[Zhu, N., Harrison, A., Trudell, M. L. & Klein-Stevens, C. L. (1999). Struct. Chem. 10, 91-103.]). For related literature, see: Meegalla et al. (1997[Meegalla, S. K., Plossl, K., Kung, M. P., Chumpradit, S., Stevenson, D. A., Kushner, S. A., McElgin, W. T., Mozley, P. D. & Kung, H. F. (1997). J. Med. Chem. 40, 9-17.]). For a description of the Cambridge Structural Database, see: Allen (2002[Allen, F. H. (2002). Acta Cryst. B58, 380-388.]).

[Scheme 1]

Experimental

Crystal data

  • C15H18ClNO2

  • Mr = 279.75

  • Monoclinic, P 21

  • a = 8.219 (6) Å

  • b = 6.501 (4) Å

  • c = 12.731 (8) Å

  • β = 100.692 (10)°

  • V = 668.4 (8) Å3

  • Z = 2

  • Mo Kα radiation

  • μ = 0.28 mm−1

  • T = 293 (2) K

  • 0.20 × 0.10 × 0.10 mm
Data collection

  • Bruker SMART APEX CCD diffractometer

  • Absorption correction: multi-scan (SADABS; Bruker, 2001[Bruker (2001). SMART and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA.]) Tmin = 0.956, Tmax = 0.976

  • 3374 measured reflections

  • 2760 independent reflections

  • 2264 reflections with I > 2σ(I)

  • Rint = 0.042
Refinement

  • R[F2 > 2σ(F2)] = 0.052

  • wR(F2) = 0.125

  • S = 0.99

  • 2760 reflections

  • 177 parameters

  • 2 restraints

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.25 e Å−3

  • Δρmin = −0.21 e Å−3

  • Absolute structure: Flack (1983[Flack, H. D. (1983). Acta Cryst. A39, 876-881.]), 1135 Friedel pairs

  • Flack parameter: −0.15 (9)

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
N10—H10X⋯O1 0.881 (17) 1.80 (2) 2.599 (3) 150 (3)
C9—H9⋯O1i 0.98 2.28 3.148 (4) 146
C16—H16A⋯O2ii 0.96 2.48 3.282 (4) 141
C14—H14A⋯O2iii 0.97 2.54 3.439 (4) 154
Symmetry codes: (i) [-x+2, y+{\script{1\over 2}}, -z]; (ii) [-x+2, y-{\script{1\over 2}}, -z]; (iii) x+1, y, z.

Data collection: SMART (Bruker, 2001[Bruker (2001). SMART and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA.]); cell refinement: SAINT (Bruker, 2001[Bruker (2001). SMART and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA.]); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL.

Supporting information

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536808025002/fj2136sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536808025002/fj2136Isup2.hkl

checkCIF report


Comment top

(2S,3S)-3-(4-halogen-phenyl)tropane-2-carboxylic acid methyl ester and analogues, the so-called "WIN compounds" reported by Clarke et al. (1973), been used extensively in medicine as monoamine uptake inhibitors and dopamine transporter (Carroll et al., 1991, 2005). Among these, only several crystal structures have been reported (Meltzer et al., 1997, 2001; Zhu et al.,1999) (Cambridge Structural Database, Version 5.29, update of November 2007; Allen, 2002). As a vital intermediate compound for the stepwise reactions of dopamine transporter-imaging agent, the crystal structure of the title compound, (I) (Fig. 1), has not been studied yet. The internal torsion angles of the tropane ring in (I) are comparable to those tropane rings in the crystal structures reported for cocaine and its derivatives. There is an intramolecular hydrogen bond between the N10 atom in the tropane ring and O1 atom of the carboxylate group (Table 1). The crystal structure is further stabilized by many weak C—H···O interactions between the intramolecules along ab plane to form two-dimensional supramolecular network.(Fig. 2 and Table 1).

Related literature top

For general background, see: Clarke et al. (1973); Carroll et al. (1991, 2005). For related structures, see: Meltzer et al. (1997, 2001); Zhu et al. (1999). For related literature, see: Meegalla et al. (1997). For a description of the Cambridge Structural Database, see: Allen (2002). .

Experimental top

Compound (I) was synthesized according to the method reported in the literature (Meegalla et al.,1997). A white powder was obtained (yield 41%) and was recrystallized from a mixed solvent composed of acetone, methanol and ether (1:1:1 v/v/v); white block-shaped crystals were obtained after several days (yield 36%). Analysis calculated for C15H18ClNO2: C 64.40, H 6.95, N 5.01%; found: C 64.17, H 6.98, N 4.90%.

Refinement top

H atoms bonded to N atom was located in a difference map and refined with distance restraints of N—H = 0.881 (17) Å, and with Uiso(H) = 1.2Ueq(N). Other H atoms were positioned geometrically and refined using a riding model (including free rotation about the ethanol C—C bond), with C—H = 0.93–0.98 Å and with Uiso(H) = 1.2 (1.5 for methyl groups) times Ueq(C).

Computing details top

Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2001); data reduction: SAINT (Bruker, 2001); program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. The molecular structure of (I), with atom labels and 50% probability displacement ellipsoids for non-H atoms.
[Figure 2] Fig. 2. Perspective view of the supramolecular network along ab plane built from intermolecular weak C—H···O hydrogen bonding interactions (dashed lines). H atoms not involved in hydrogen bonding have been omitted.
(2S,3S)3-(4-Chlorophenyl)-8-methyltropane-2-carboxylic acid top
Crystal data top
C15H18ClNO2F(000) = 296
Mr = 279.75Dx = 1.390 Mg m−3
Monoclinic, P21Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ybCell parameters from 742 reflections
a = 8.219 (6) Åθ = 3.3–26.8°
b = 6.501 (4) ŵ = 0.28 mm−1
c = 12.731 (8) ÅT = 293 K
β = 100.692 (10)°Block, white
V = 668.4 (8) Å30.20 × 0.10 × 0.10 mm
Z = 2
Data collection top
Bruker SMART APEX CCD
diffractometer		2760 independent reflections
Radiation source: fine-focus sealed tube2264 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.042
ϕ and ω scansθmax = 27.2°, θmin = 1.6°
Absorption correction: multi-scan
(SADABS; Bruker, 2001)		h = −8→10
Tmin = 0.956, Tmax = 0.976k = −8→8
3374 measured reflectionsl = −16→13
Refinement top
Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.052H atoms treated by a mixture of independent and constrained refinement
wR(F2) = 0.125 w = 1/[σ2(Fo2) + (0.0695P)2]
where P = (Fo2 + 2Fc2)/3
S = 0.99(Δ/σ)max < 0.001
2760 reflectionsΔρmax = 0.25 e Å−3
177 parametersΔρmin = −0.21 e Å−3
2 restraintsAbsolute structure: Flack (1983), 1135 Friedel pairs
Primary atom site location: structure-invariant direct methodsAbsolute structure parameter: −0.15 (9)
Crystal data top
C15H18ClNO2V = 668.4 (8) Å3
Mr = 279.75Z = 2
Monoclinic, P21Mo Kα radiation
a = 8.219 (6) ŵ = 0.28 mm−1
b = 6.501 (4) ÅT = 293 K
c = 12.731 (8) Å0.20 × 0.10 × 0.10 mm
β = 100.692 (10)°
Data collection top
Bruker SMART APEX CCD
diffractometer		2760 independent reflections
Absorption correction: multi-scan
(SADABS; Bruker, 2001)		2264 reflections with I > 2σ(I)
Tmin = 0.956, Tmax = 0.976Rint = 0.042
3374 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.052H atoms treated by a mixture of independent and constrained refinement
wR(F2) = 0.125Δρmax = 0.25 e Å−3
S = 0.99Δρmin = −0.21 e Å−3
2760 reflectionsAbsolute structure: Flack (1983), 1135 Friedel pairs
177 parametersAbsolute structure parameter: −0.15 (9)
2 restraints
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
Cl10.58072 (10)0.59422 (16)0.46455 (6)0.0650 (3)
O10.9356 (2)1.0348 (4)0.03436 (15)0.0508 (6)
O20.7924 (2)1.2275 (4)0.12844 (18)0.0614 (6)
C10.9057 (3)0.6847 (5)0.2742 (2)0.0414 (7)
H20.93760.61700.21690.050*
C20.7841 (3)0.6008 (5)0.3216 (2)0.0439 (7)
H30.73540.47630.29720.053*
C30.7350 (3)0.7004 (5)0.4043 (2)0.0433 (7)
C40.8053 (4)0.8847 (5)0.4423 (2)0.0464 (7)
H40.77030.95230.49850.056*
C50.9290 (3)0.9666 (5)0.3950 (2)0.0432 (7)
H50.97791.09020.42060.052*
C60.9824 (3)0.8694 (4)0.3104 (2)0.0335 (6)
C71.1233 (3)0.9616 (4)0.2641 (2)0.0350 (6)
H71.20840.99960.32560.042*
C81.0761 (3)1.1622 (4)0.2018 (2)0.0333 (6)
H81.05361.26650.25280.040*
C91.2231 (3)1.2388 (5)0.1525 (2)0.0361 (6)
H91.19761.37070.11590.043*
N101.2558 (3)1.0745 (4)0.07558 (17)0.0362 (5)
H10X1.157 (2)1.032 (5)0.045 (2)0.039 (8)*
C111.3402 (4)0.9115 (5)0.1503 (2)0.0463 (8)
H111.39690.81170.11210.056*
C121.2061 (4)0.8080 (4)0.1992 (2)0.0413 (7)
H12A1.25450.69670.24540.050*
H12B1.12330.74970.14280.050*
C131.3871 (3)1.2488 (5)0.2315 (3)0.0478 (8)
H13A1.36881.28140.30270.057*
H13B1.45921.35240.20990.057*
C141.4630 (3)1.0344 (6)0.2289 (2)0.0532 (8)
H14A1.56881.04200.20570.064*
H14B1.47970.97170.29920.064*
C150.9197 (3)1.1414 (4)0.1143 (2)0.0377 (6)
C161.3556 (4)1.1475 (5)−0.0028 (2)0.0484 (8)
H16A1.35831.0429−0.05570.073*
H16B1.46641.17660.03340.073*
H16C1.30681.2702−0.03690.073*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
Cl10.0584 (5)0.0864 (7)0.0526 (4)−0.0214 (5)0.0165 (4)0.0042 (5)
O10.0448 (12)0.0607 (15)0.0420 (11)−0.0054 (10)−0.0048 (9)−0.0107 (10)
O20.0358 (11)0.0697 (15)0.0758 (16)0.0112 (11)0.0029 (11)−0.0032 (13)
C10.0427 (15)0.0443 (18)0.0368 (14)−0.0029 (13)0.0060 (12)−0.0063 (12)
C20.0450 (15)0.0397 (16)0.0451 (15)−0.0061 (14)0.0033 (12)−0.0024 (14)
C30.0341 (14)0.059 (2)0.0348 (14)−0.0067 (13)0.0003 (12)0.0086 (14)
C40.0455 (17)0.060 (2)0.0342 (15)−0.0006 (15)0.0076 (12)−0.0077 (14)
C50.0429 (16)0.0426 (17)0.0424 (15)−0.0034 (13)0.0036 (12)−0.0102 (14)
C60.0327 (14)0.0343 (15)0.0311 (13)0.0039 (11)−0.0008 (11)0.0017 (11)
C70.0349 (14)0.0312 (14)0.0366 (13)0.0003 (11)0.0008 (11)−0.0014 (11)
C80.0336 (13)0.0300 (14)0.0352 (13)−0.0006 (10)0.0035 (11)−0.0050 (11)
C90.0365 (14)0.0340 (15)0.0352 (14)−0.0047 (12)0.0001 (11)−0.0025 (12)
N100.0327 (11)0.0390 (13)0.0359 (11)−0.0026 (10)0.0041 (9)−0.0007 (10)
C110.0444 (17)0.0428 (18)0.0535 (18)0.0140 (13)0.0141 (14)0.0073 (14)
C120.0468 (17)0.0317 (15)0.0478 (17)0.0072 (12)0.0152 (14)0.0047 (12)
C130.0370 (16)0.059 (2)0.0447 (17)−0.0138 (15)0.0005 (13)−0.0033 (15)
C140.0316 (14)0.074 (2)0.0516 (18)0.0067 (15)0.0024 (13)0.0168 (16)
C150.0334 (14)0.0333 (14)0.0441 (15)−0.0019 (11)0.0012 (12)0.0058 (12)
C160.0463 (16)0.055 (2)0.0462 (15)−0.0037 (14)0.0140 (13)0.0037 (14)
Geometric parameters (Å, º) top
Cl1—C31.742 (3)C9—N101.506 (4)
O1—C151.258 (3)C9—C131.526 (4)
O2—C151.229 (3)C9—H90.9800
C1—C21.373 (4)N10—C161.482 (3)
C1—C61.394 (4)N10—C111.505 (4)
C1—H20.9300N10—H10X0.881 (17)
C2—C31.360 (4)C11—C141.511 (5)
C2—H30.9300C11—C121.520 (4)
C3—C41.378 (5)C11—H110.9800
C4—C51.380 (4)C12—H12A0.9700
C4—H40.9300C12—H12B0.9700
C5—C61.388 (4)C13—C141.530 (5)
C5—H50.9300C13—H13A0.9700
C6—C71.517 (4)C13—H13B0.9700
C7—C121.533 (4)C14—H14A0.9700
C7—C81.538 (4)C14—H14B0.9700
C7—H70.9800C16—H16A0.9599
C8—C151.542 (4)C16—H16B0.9599
C8—C91.544 (4)C16—H16C0.9599
C8—H80.9800
C2—C1—C6121.2 (3)C11—N10—C9101.8 (2)
C2—C1—H2119.4C16—N10—H10X112.8 (17)
C6—C1—H2119.4C11—N10—H10X110 (2)
C3—C2—C1119.7 (3)C9—N10—H10X104.4 (19)
C3—C2—H3120.1N10—C11—C14102.7 (3)
C1—C2—H3120.1N10—C11—C12106.7 (2)
C2—C3—C4121.4 (3)C14—C11—C12114.1 (3)
C2—C3—Cl1119.8 (2)N10—C11—H11111.0
C4—C3—Cl1118.8 (2)C14—C11—H11111.0
C3—C4—C5118.5 (3)C12—C11—H11111.0
C3—C4—H4120.8C11—C12—C7111.1 (2)
C5—C4—H4120.8C11—C12—H12A109.4
C4—C5—C6121.8 (3)C7—C12—H12A109.4
C4—C5—H5119.1C11—C12—H12B109.4
C6—C5—H5119.1C7—C12—H12B109.4
C5—C6—C1117.4 (3)H12A—C12—H12B108.0
C5—C6—C7119.7 (2)C9—C13—C14105.1 (3)
C1—C6—C7122.8 (2)C9—C13—H13A110.7
C6—C7—C12113.6 (2)C14—C13—H13A110.7
C6—C7—C8113.4 (2)C9—C13—H13B110.7
C12—C7—C8111.7 (2)C14—C13—H13B110.7
C6—C7—H7105.8H13A—C13—H13B108.8
C12—C7—H7105.8C11—C14—C13105.7 (2)
C8—C7—H7105.8C11—C14—H14A110.6
C7—C8—C15113.2 (2)C13—C14—H14A110.6
C7—C8—C9109.9 (2)C11—C14—H14B110.6
C15—C8—C9110.2 (2)C13—C14—H14B110.6
C7—C8—H8107.8H14A—C14—H14B108.7
C15—C8—H8107.8O2—C15—O1126.1 (3)
C9—C8—H8107.8O2—C15—C8118.2 (3)
N10—C9—C13102.5 (2)O1—C15—C8115.7 (2)
N10—C9—C8106.5 (2)N10—C16—H16A109.5
C13—C9—C8114.1 (2)N10—C16—H16B109.5
N10—C9—H9111.1H16A—C16—H16B109.5
C13—C9—H9111.1N10—C16—H16C109.5
C8—C9—H9111.1H16A—C16—H16C109.5
C16—N10—C11113.8 (2)H16B—C16—H16C109.5
C16—N10—C9113.5 (2)
C6—C1—C2—C31.0 (4)C13—C9—N10—C16−77.9 (3)
C1—C2—C3—C4−0.2 (4)C8—C9—N10—C16162.0 (2)
C1—C2—C3—Cl1−180.0 (2)C13—C9—N10—C1144.8 (3)
C2—C3—C4—C5−0.6 (4)C8—C9—N10—C11−75.3 (2)
Cl1—C3—C4—C5179.2 (2)C16—N10—C11—C1477.3 (3)
C3—C4—C5—C60.6 (5)C9—N10—C11—C14−45.3 (2)
C4—C5—C6—C10.2 (4)C16—N10—C11—C12−162.4 (2)
C4—C5—C6—C7−177.7 (3)C9—N10—C11—C1275.1 (3)
C2—C1—C6—C5−1.0 (4)N10—C11—C12—C7−62.0 (3)
C2—C1—C6—C7176.8 (3)C14—C11—C12—C750.7 (3)
C5—C6—C7—C12160.8 (2)C6—C7—C12—C11177.2 (2)
C1—C6—C7—C12−16.9 (4)C8—C7—C12—C1147.4 (3)
C5—C6—C7—C8−70.3 (3)N10—C9—C13—C14−27.1 (3)
C1—C6—C7—C8112.0 (3)C8—C9—C13—C1487.5 (3)
C6—C7—C8—C15−53.2 (3)N10—C11—C14—C1328.0 (3)
C12—C7—C8—C1576.6 (3)C12—C11—C14—C13−87.0 (3)
C6—C7—C8—C9−177.0 (2)C9—C13—C14—C11−0.5 (3)
C12—C7—C8—C9−47.1 (3)C7—C8—C15—O2109.1 (3)
C7—C8—C9—N1062.1 (2)C9—C8—C15—O2−127.3 (3)
C15—C8—C9—N10−63.3 (3)C7—C8—C15—O1−70.6 (3)
C7—C8—C9—C13−50.1 (3)C9—C8—C15—O153.0 (3)
C15—C8—C9—C13−175.6 (2)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N10—H10X···O10.88 (2)1.80 (2)2.599 (3)150 (3)
C9—H9···O1i0.982.283.148 (4)146
C16—H16A···O2ii0.962.483.282 (4)141
C14—H14A···O2iii0.972.543.439 (4)154
Symmetry codes: (i) −x+2, y+1/2, −z; (ii) −x+2, y−1/2, −z; (iii) x+1, y, z.

Experimental details

Crystal data
Chemical formulaC15H18ClNO2
Mr279.75
Crystal system, space groupMonoclinic, P21
Temperature (K)293
a, b, c (Å)8.219 (6), 6.501 (4), 12.731 (8)
β (°) 100.692 (10)
V (Å3)668.4 (8)
Z2
Radiation typeMo Kα
µ (mm−1)0.28
Crystal size (mm)0.20 × 0.10 × 0.10
Data collection
DiffractometerBruker SMART APEX CCD
diffractometer
Absorption correctionMulti-scan
(SADABS; Bruker, 2001)
Tmin, Tmax0.956, 0.976
No. of measured, independent and
observed [I > 2σ(I)] reflections		3374, 2760, 2264
Rint0.042
(sin θ/λ)max (Å−1)0.642
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.052, 0.125, 0.99
No. of reflections2760
No. of parameters177
No. of restraints2
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å−3)0.25, −0.21
Absolute structureFlack (1983), 1135 Friedel pairs
Absolute structure parameter−0.15 (9)

Computer programs: SMART (Bruker, 2001), SAINT (Bruker, 2001), SHELXTL (Sheldrick, 2008).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N10—H10X···O10.881 (17)1.80 (2)2.599 (3)150 (3)
C9—H9···O1i0.982.283.148 (4)146
C16—H16A···O2ii0.962.483.282 (4)141
C14—H14A···O2iii0.972.543.439 (4)154
Symmetry codes: (i) −x+2, y+1/2, −z; (ii) −x+2, y−1/2, −z; (iii) x+1, y, z.
 

Acknowledgements

This work was supported by the National Natural Science Foundation of China (30570518), the High Technology Research and Development Program of Jiangsu Province of China (BG2007603) and the Science Foundation of the Health Department of Jiangsu Province (H200401).

References

First citationAllen, F. H. (2002). Acta Cryst. B58, 380–388.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationBruker (2001). SMART and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA.  Google Scholar
 First citationCarroll, F. I., Gao, Y. G., Rahman, M. A., Abraham, P., Parham, K., Lewin, A. H., Boja, J. W. & Kuhart, M. J. (1991). J. Med. Chem. 34, 2719–2725.  CrossRef PubMed CAS Web of Science Google Scholar
 First citationCarroll, F. I., Tyagi, S., Blough, B. E., Kuhar, M. J. & Navarro, H. A. (2005). J. Med. Chem. 48, 3852–3857.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationClarke, R. L., Daum, S. J., Gambino, A. J., Aceto, M. D., Pearl, J., Levitt, M., Cumiskey, W. R. & Bogado, E. F. (1973). J. Med. Chem. 16, 1260–1267.  CrossRef CAS PubMed Web of Science Google Scholar
 First citationFlack, H. D. (1983). Acta Cryst. A39, 876–881.  CrossRef CAS Web of Science IUCr Journals Google Scholar
 First citationMeegalla, S. K., Plossl, K., Kung, M. P., Chumpradit, S., Stevenson, D. A., Kushner, S. A., McElgin, W. T., Mozley, P. D. & Kung, H. F. (1997). J. Med. Chem. 40, 9–17.  CrossRef CAS PubMed Web of Science Google Scholar
 First citationMeltzer, P. C., Liang, A. Y., Blundell, P., Gonzalez, M. D., Chen, Z. M. & Madras, B. K. (1997). J. Med. Chem. 40, 2661–2673.  CSD CrossRef CAS PubMed Web of Science Google Scholar
 First citationMeltzer, P. C., Wang, B., Chen, Z. M., Blundell, P., Jayaraman, M., Gonzalez, M. D., George, C. & Madras, B. K. (2001). J. Med. Chem. 44, 2619–2635.  Web of Science CSD CrossRef PubMed CAS Google Scholar
 First citationSheldrick, G. M. (2008). Acta Cryst. A64, 112–122.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationZhu, N., Harrison, A., Trudell, M. L. & Klein-Stevens, C. L. (1999). Struct. Chem. 10, 91–103.  Web of Science CSD CrossRef CAS Google Scholar

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 64| Part 9| September 2008| Page o1732
doi:10.1107/S1600536808025002
Follow Acta Cryst. E
Sign up for e-alerts
E-alerts
Follow Acta Cryst. on Twitter
Twitter
Follow us on facebook
Facebook
Sign up for RSS feeds
RSS