4,5,7-Trimeth­oxy-2-methyl-3-(2,4,5-trimethoxy­phen­yl)-1-[3-(2,4,5-tri­methoxy­phen­yl)pentan-2-yl]indane acetone 0.858-solvate

Liu, C.; Xu, G.

doi:10.1107/S1600536809018613

organic compounds

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ISSN: 2056-9890

Volume 65| Part 6| June 2009| Page o1379

doi:10.1107/S1600536809018613

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4,5,7-Trimethoxy-2-methyl-3-(2,4,5-trimethoxyphenyl)-1-[3-(2,4,5-trimethoxyphenyl)pentan-2-yl]indane acetone 0.858-solvate

Chang Liu ^a and Guangyu Xu ^a ^*

^aCollege of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, People's Republic of China
^*Correspondence e-mail: gyxu@hunnu.edu.cn

(Received 7 March 2009; accepted 17 May 2009; online 23 May 2009)

In the title compound, C₃₆H₄₈O₉.0.858C₃H₆O, the five-membered ring adopts an envelope conformation. The acetone solvent molecule was disordered and was refined over two positions with equal occupancies, giving an overall occupancy of 0.858 (4). There are weak intramolecular C—H⋯O hydrogen bonds and intermolecular C—H⋯π interactions in the structure.

Related literature

For general background, see: Diaz et al. (1993 ); Hernandez et al. (1993 ); Menon & Dandiya (1967 ); Belova et al. (1985 ); Xu et al. (2009 ). For related structures, see: Lemini et al. (1990 ).

Experimental

Crystal data

C₃₆H₄₈09·0.858C₃H₆O
M_r = 674.57
Triclinic, $[P \overline 1]$
a = 8.9234 (10) Å
b = 13.2672 (14) Å
c = 16.3992 (18) Å
α = 87.757 (2)°
β = 80.0900 (1)°
γ = 76.0220 (1)°
V = 1855.9 (4) Å³
Z = 2
Mo Kα radiation
μ = 0.09 mm⁻¹
T = 298 K
0.49 × 0.41 × 0.03 mm

Data collection

Bruker SMART APEX area-detector diffractometer
Absorption correction: multi-scan (SADABS; Bruker, 1998 ) T_min = 0.959, T_max = 0.997
9730 measured reflections
6438 independent reflections
3660 reflections with I > 2σ(I)
R_int = 0.029

Refinement

R[F² > 2σ(F²)] = 0.055
wR(F²) = 0.174
S = 1.01
6438 reflections
495 parameters
84 restraints
H-atom parameters constrained
Δρ_max = 0.40 e Å⁻³
Δρ_min = −0.24 e Å⁻³

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C17—H17⋯O7	0.98	2.35	2.820 (3)	109
C25—H25B⋯O2	0.96	2.27	2.912 (5)	123
C28—H28A⋯Cg1ⁱ	0.96	2.93	3.565 (4)	125
Symmetry code: (i) -x+1, -y+1, -z. Cg1 is the centroid of the C18–C23 ring.

Data collection: SMART (Bruker, 1998); cell refinement: SAINT (Bruker, 1998); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL.

Supporting information

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809018613/fb2143sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536809018613/fb2143Isup2.hkl

checkCIF report

Comment top

α-Asarone, (III) (Scheme 2), isolated from the Guatteria guameri plant growing in Southeast Mexico, is reported to be an antiplatelet and hypolipidemic agent (Diaz et al., 1993; Hernandez et al., 1993). In addition, it is known to have sedative, neuroleptic, spasmolytic, antiulcerogenic and antiatherogenic activities (Menon & Dandiya, 1967; Belova et al., 1985). As a part of our studies on the optimization of the synthesis of α-asarone (Xu et al., 2009), three by-products, two asarone dimers (Lemini et al., 1990) and the asarone trimer, the title compound (I), were isolated and identified from the crude product. The structure of the asarone dimers was reported by Lemini et al. (1990). In this paper, the structure of the title compound (I) is reported.

As shown in Fig. 1 and Fig. 2, the five-membered ring C4\C3\C5\C1\C2 has an envelope conformation. C4\C3\C5\C1 is nearly planar with the mean deviation of 0.0043 (3) Å and C2 is situated 0.500 (4) Å out of the C4\C3\C5\C1 plane. The benzene ring (C4 to C9) is almost perpendicular to the other two benzene rings (C10 to C15; C18 to C23) with the interplanar angles of 85.05 (9) and 77.58 (7)°, respectively, while the interplanar angle between the benzene rings (C10 to C15 and C18 to C23) equals to 61.31 (10)°. As shown in Fig. 3, the acetone solvate was disordered and it was refined in two positions with equal occupancies giving the overall occupancy 0.858 (4). This means that the content of acetone is lesser than that of asarone trimer, or in other words, that in some unit cells the acetone molecule is not present. The molecular and crystal structure of the title compound is stabilized by intramolecular weak C-H···O hydrogen bonds and C-H···π-ring electron interactions (Table 1).

Related literature top

For general background, see: Diaz et al. (1993); Hernandez et al. (1993); Menon & Dandiya (1967); Belova et al. (1985); Xu et al. (2009). For related structures, see: Lemini et al. (1990).

Experimental top

In the α-asarone preparation from 2,4,5-trimethoxybenzaldehyde (Xu et al., 2009), the crude product, containing α-asarone, asarone dimers and asarone trimer and other unknown impurities, was dissolved in hot EtOH/H₂O (V:V 7:3), and then cooled and filtrated. The yellow powder, obtained by concentrating of the filtrate in vacuo, was dissolved again in EtOH/H₂O (V:V 7:3), and then cooled and filtrated. The filtrate afforded a yellow oil after removal of the solvents under reduced pressure. Fifty grams of the yellow oil was subjected to column chromatography on silica gel and eluted with hexane - ethyl acetate (4:1), the Rf 0.32 fraction was collected and evaporated under vacuum. The residue was crystallized from ethanol to afford the title compound (I). White solid, m.p. 408 K, ¹H NMR (CDCl₃, p.p.m.): 0.58 (t, 3 H, J = 9.6 Hz), 0.63 (d, 3 H, J = 9.6 Hz), 1.66 (d, 3 H, J = 8.8 Hz), 1.43 (m, 1 H), 1.73 (m, 2 H,), 2.21 (m, 1 H), 2.83 (dd, 1 H, J = 5.6, 7.2 Hz), 3.20 (m, 1 H), 3.44 (s, 3 H), 3.61 (s, 3 H), 3.73 (s, 3 H), 3.77 (s, 3 H), 3.79 (s, 3 H), 3.86 (s, 3 H), 3.86 (s, 3 H), 3.88 (s, 6 H), 4.21 (d, 1 H, J =5.2 Hz), 6.40 (s, 1 H), 6.43 (s, 1 H), 6.48 (s, 1 H), 6.55 (s, 1 H), 6.59 (s, 1 H). ¹³C NMR (CDCl₃, p.p.m.): 12.4, 14.9, 21.0, 26.2, 42.1, 49.3, 49.6, 53.1, 55.1, 56.0, 56.2, 56.4, 56.5, 56.5, 56.6, 56.7, 60.0, 96.5, 97.7, 97.9, 113.0, 125.2, 126.7, 127.0, 139.7, 139.9, 142.5, 142.8, 147.0, 147.5, 151.2, 151.8, 152.4, 152.8. The single crystals were obtained by slow evaporation of the title compound dissolved in acetone at room temperature on the third day.

Computing details top

Data collection: SMART (Bruker, 1998); cell refinement: SAINT (Bruker, 1998); data reduction: SAINT (Bruker, 1998); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top

	Fig. 1. The title molecule without the acetone solvate. The displacement ellipsoids are drawn at the 30% probability level.
	Fig. 2. The title molecule with the disordered acetone solvate. The displacement ellipsoids are drawn at the 30% probability level.
	Fig. 3. The disordered acetone solvate. The displacement ellipsoids are drawn at the 30% probability level.
	Fig. 4. Schematic representations of the title molecule (I) without the acetone solvent olecule, asarone dimers (IIa) and (IIb) (Lemini et al., 1990) and α-asarone monomer (III) (Xu et al., 2009)

4,5,7-Trimethoxy-2-methyl-3-(2,4,5-trimethoxyphenyl)-1-[3-(2,4,5- trimethoxyphenyl)pentan-2-yl]indane acetone 0.858-solvate top

Crystal data top

C₃₆H₄₈09·0.858C₃H₆O	Z = 2
M_r = 674.57	F(000) = 727
Triclinic, P1	D_x = 1.207 Mg m⁻³
Hall symbol: -P 1	Melting point: 408 K
a = 8.9234 (10) Å	Mo Kα radiation, λ = 0.71073 Å
b = 13.2672 (14) Å	Cell parameters from 2731 reflections
c = 16.3992 (18) Å	θ = 2.5–27.8°
α = 87.757 (2)°	µ = 0.09 mm⁻¹
β = 80.0900 (1)°	T = 298 K
γ = 76.0220 (1)°	Plate, colourless
V = 1855.9 (4) Å³	0.49 × 0.41 × 0.03 mm

Data collection top

Bruker APEX area-detector diffractometer	6438 independent reflections
Radiation source: fine-focus sealed tube	3660 reflections with I > 2σ(I)
Graphite monochromator	R_int = 0.029
ϕ and ω scans	θ_max = 25.0°, θ_min = 1.6°
Absorption correction: multi-scan (SADABS; Bruker, 1998)	h = −10→10
T_min = 0.959, T_max = 0.997	k = −15→12
9730 measured reflections	l = −19→19

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.055	Hydrogen site location: inferred from neighbouring sites
wR(F²) = 0.174	H-atom parameters constrained
S = 1.01	w = 1/[σ²(F_o²) + (0.0748P)² + 0.7819P] where P = (F_o² + 2F_c²)/3
6438 reflections	(Δ/σ)_max < 0.001
495 parameters	Δρ_max = 0.40 e Å⁻³
84 restraints	Δρ_min = −0.24 e Å⁻³

Crystal data top

C₃₆H₄₈09·0.858C₃H₆O	γ = 76.0220 (1)°
M_r = 674.57	V = 1855.9 (4) Å³
Triclinic, P1	Z = 2
a = 8.9234 (10) Å	Mo Kα radiation
b = 13.2672 (14) Å	µ = 0.09 mm⁻¹
c = 16.3992 (18) Å	T = 298 K
α = 87.757 (2)°	0.49 × 0.41 × 0.03 mm
β = 80.0900 (1)°

Data collection top

Bruker APEX area-detector diffractometer	6438 independent reflections
Absorption correction: multi-scan (SADABS; Bruker, 1998)	3660 reflections with I > 2σ(I)
T_min = 0.959, T_max = 0.997	R_int = 0.029
9730 measured reflections

Refinement top

R[F² > 2σ(F²)] = 0.055	84 restraints
wR(F²) = 0.174	H-atom parameters constrained
S = 1.01	Δρ_max = 0.40 e Å⁻³
6438 reflections	Δρ_min = −0.24 e Å⁻³
495 parameters

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq	Occ. (<1)
O1	1.1931 (2)	0.14498 (15)	0.22957 (13)	0.0519 (6)
O4	0.9453 (3)	0.25903 (16)	−0.01442 (11)	0.0510 (6)
O2	1.1952 (3)	0.16737 (17)	0.39503 (14)	0.0673 (7)
O6	0.7166 (3)	−0.01714 (17)	0.20417 (13)	0.0619 (6)
O5	0.7116 (3)	−0.03625 (16)	0.04828 (13)	0.0601 (6)
O9	0.0148 (3)	0.66946 (18)	0.36065 (14)	0.0633 (6)
O7	0.5805 (3)	0.66492 (16)	0.15812 (14)	0.0580 (6)
O3	0.7466 (3)	0.46292 (17)	0.40510 (13)	0.0604 (6)
O8	0.1064 (3)	0.84904 (18)	0.33474 (16)	0.0762 (8)
C10	0.8901 (3)	0.2026 (2)	0.12217 (16)	0.0359 (7)
C11	0.8868 (3)	0.1895 (2)	0.03872 (17)	0.0386 (7)
C2	0.8520 (3)	0.4007 (2)	0.13985 (17)	0.0379 (7)
H2	0.7865	0.4008	0.0976	0.045*
C4	0.8538 (3)	0.3652 (2)	0.28242 (17)	0.0380 (7)
C6	1.0852 (3)	0.2234 (2)	0.27625 (18)	0.0420 (7)
C18	0.3909 (3)	0.5759 (2)	0.22003 (17)	0.0386 (7)
C14	0.7756 (3)	0.0537 (2)	0.15255 (18)	0.0425 (7)
C5	0.9700 (3)	0.2873 (2)	0.23899 (17)	0.0371 (7)
C17	0.4851 (3)	0.4764 (2)	0.17502 (17)	0.0396 (7)
H17	0.5580	0.4977	0.1297	0.047*
C3	0.7474 (3)	0.4266 (2)	0.22550 (16)	0.0370 (7)
H3	0.7293	0.5009	0.2368	0.044*
C19	0.4390 (4)	0.6688 (2)	0.20851 (19)	0.0449 (7)
C16	0.5879 (3)	0.3984 (2)	0.22794 (17)	0.0388 (7)
H16	0.6112	0.3307	0.2006	0.047*
C9	0.8590 (4)	0.3818 (2)	0.36492 (18)	0.0454 (8)
C13	0.7717 (3)	0.0435 (2)	0.06860 (18)	0.0430 (7)
C8	0.9742 (4)	0.3178 (2)	0.40316 (19)	0.0516 (8)
H8	0.9774	0.3290	0.4584	0.062*
C22	0.1547 (4)	0.6702 (2)	0.30812 (18)	0.0471 (8)
C23	0.2479 (3)	0.5802 (2)	0.27077 (17)	0.0422 (7)
H23	0.2134	0.5193	0.2800	0.051*
C1	0.9554 (3)	0.2895 (2)	0.14877 (16)	0.0369 (7)
H1	1.0592	0.2851	0.1156	0.044*
C7	1.0842 (4)	0.2374 (2)	0.36009 (19)	0.0487 (8)
C24	0.9528 (4)	0.4779 (2)	0.1168 (2)	0.0527 (8)
H24A	1.0092	0.4823	0.1609	0.079*
H24B	0.8873	0.5449	0.1080	0.079*
H24C	1.0257	0.4553	0.0671	0.079*
C12	0.8280 (4)	0.1111 (2)	0.01227 (18)	0.0437 (7)
H12	0.8265	0.1040	−0.0438	0.052*
C32	0.3788 (4)	0.4259 (3)	0.1338 (2)	0.0533 (8)
H32A	0.3224	0.3889	0.1757	0.064*
H32B	0.3021	0.4804	0.1122	0.064*
C21	0.2052 (4)	0.7620 (2)	0.2949 (2)	0.0539 (9)
C28	0.9350 (5)	0.2536 (3)	−0.09955 (19)	0.0660 (10)
H28A	0.8274	0.2628	−0.1055	0.099*
H28B	0.9942	0.1871	−0.1214	0.099*
H28C	0.9766	0.3074	−0.1293	0.099*
C31	0.5048 (4)	0.3847 (3)	0.31565 (19)	0.0545 (9)
H31A	0.5683	0.3284	0.3421	0.082*
H31B	0.4057	0.3694	0.3133	0.082*
H31C	0.4880	0.4475	0.3466	0.082*
C20	0.3467 (4)	0.7606 (2)	0.2450 (2)	0.0529 (8)
H20	0.3805	0.8218	0.2357	0.063*
C29	0.7102 (4)	−0.0519 (3)	−0.0364 (2)	0.0648 (10)
H29A	0.6718	−0.1123	−0.0424	0.097*
H29B	0.8147	−0.0616	−0.0669	0.097*
H29C	0.6433	0.0077	−0.0574	0.097*
C34	0.6242 (5)	0.7593 (3)	0.1351 (3)	0.0792 (12)
H34A	0.6383	0.7922	0.1833	0.119*
H34B	0.5435	0.8044	0.1100	0.119*
H34C	0.7205	0.7450	0.0963	0.119*
C27	0.7729 (6)	0.4980 (3)	0.4807 (2)	0.0951 (15)
H27A	0.6969	0.5615	0.4973	0.143*
H27B	0.8762	0.5100	0.4735	0.143*
H27C	0.7633	0.4463	0.5227	0.143*
C33	0.4646 (5)	0.3512 (3)	0.0641 (2)	0.0806 (12)
H33A	0.3901	0.3262	0.0397	0.121*
H33B	0.5346	0.2937	0.0857	0.121*
H33C	0.5235	0.3864	0.0229	0.121*
C25	1.3527 (4)	0.1453 (3)	0.2235 (3)	0.0806 (12)
H25A	1.4164	0.0842	0.1943	0.121*
H25B	1.3781	0.1457	0.2780	0.121*
H25C	1.3722	0.2060	0.1941	0.121*
C30	0.7076 (5)	−0.0056 (3)	0.2900 (2)	0.0758 (11)
H30A	0.6516	−0.0532	0.3191	0.114*
H30B	0.6535	0.0642	0.3062	0.114*
H30C	0.8114	−0.0201	0.3032	0.114*
C35	0.1433 (6)	0.9472 (3)	0.3104 (3)	0.0986 (15)
H35A	0.0658	1.0025	0.3402	0.148*
H35B	0.1442	0.9571	0.2521	0.148*
H35C	0.2446	0.9473	0.3229	0.148*
C26	1.2133 (6)	0.1858 (3)	0.4760 (2)	0.0931 (15)
H26A	1.2986	0.1333	0.4912	0.140*
H26B	1.1187	0.1839	0.5134	0.140*
H26C	1.2352	0.2528	0.4788	0.140*
C36	−0.1154 (5)	0.6869 (4)	0.3199 (3)	0.1014 (15)
H36A	−0.2094	0.6948	0.3601	0.152*
H36B	−0.1055	0.6290	0.2844	0.152*
H36C	−0.1202	0.7490	0.2873	0.152*
C15	0.8340 (3)	0.1327 (2)	0.17745 (18)	0.0412 (7)
H15	0.8360	0.1394	0.2335	0.049*
C38A	0.5792 (18)	0.2552 (10)	0.5382 (9)	0.099 (3)	0.429 (3)
H38A	0.5361	0.2849	0.4905	0.148*	0.429 (3)
H38B	0.6648	0.2845	0.5447	0.148*	0.429 (3)
H38C	0.4998	0.2700	0.5866	0.148*	0.429 (3)
C39A	0.7892 (15)	0.1035 (12)	0.4803 (9)	0.123 (4)	0.429 (3)
H39A	0.7878	0.1183	0.4226	0.184*	0.429 (3)
H39B	0.8182	0.0297	0.4881	0.184*	0.429 (3)
H39C	0.8637	0.1347	0.4989	0.184*	0.429 (3)
O36A	0.5576 (11)	0.0861 (8)	0.5564 (6)	0.128 (3)	0.429 (3)
C37A	0.6341 (13)	0.1455 (9)	0.5276 (8)	0.080 (3)	0.429 (3)
C38B	0.5848 (16)	0.3015 (8)	0.5510 (8)	0.089 (3)	0.429 (3)
H38D	0.5885	0.3306	0.4963	0.133*	0.429 (3)
H38E	0.6729	0.3104	0.5738	0.133*	0.429 (3)
H38F	0.4896	0.3363	0.5855	0.133*	0.429 (3)
C39B	0.7096 (19)	0.1325 (13)	0.4835 (10)	0.130 (4)	0.429 (3)
H39D	0.7284	0.1757	0.4364	0.196*	0.429 (3)
H39E	0.6744	0.0747	0.4671	0.196*	0.429 (3)
H39F	0.8048	0.1074	0.5055	0.196*	0.429 (3)
O36B	0.5069 (10)	0.1506 (7)	0.5948 (5)	0.112 (2)	0.429 (3)
C37B	0.5899 (15)	0.1928 (9)	0.5469 (7)	0.073 (3)	0.429 (3)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
O1	0.0451 (13)	0.0443 (12)	0.0616 (14)	0.0069 (10)	−0.0179 (11)	−0.0153 (10)
O4	0.0677 (15)	0.0575 (13)	0.0348 (11)	−0.0266 (11)	−0.0111 (10)	0.0008 (10)
O2	0.0777 (17)	0.0596 (14)	0.0572 (14)	0.0192 (12)	−0.0394 (13)	−0.0097 (11)
O6	0.0840 (18)	0.0537 (14)	0.0529 (14)	−0.0287 (13)	−0.0082 (12)	0.0035 (11)
O5	0.0794 (17)	0.0522 (14)	0.0570 (14)	−0.0287 (12)	−0.0132 (12)	−0.0112 (11)
O9	0.0528 (15)	0.0731 (16)	0.0535 (14)	−0.0001 (12)	0.0002 (12)	−0.0050 (11)
O7	0.0507 (14)	0.0446 (13)	0.0778 (16)	−0.0155 (11)	−0.0045 (12)	0.0095 (11)
O3	0.0615 (15)	0.0623 (14)	0.0477 (13)	0.0129 (12)	−0.0179 (11)	−0.0195 (11)
O8	0.0833 (19)	0.0445 (14)	0.0900 (19)	0.0004 (13)	−0.0031 (15)	−0.0185 (13)
C10	0.0336 (16)	0.0352 (15)	0.0363 (16)	0.0001 (13)	−0.0094 (13)	−0.0045 (12)
C11	0.0367 (17)	0.0405 (17)	0.0378 (16)	−0.0071 (13)	−0.0063 (13)	−0.0029 (13)
C2	0.0355 (16)	0.0386 (16)	0.0400 (16)	−0.0059 (13)	−0.0115 (13)	−0.0015 (12)
C4	0.0374 (17)	0.0356 (16)	0.0417 (17)	−0.0054 (13)	−0.0132 (13)	−0.0013 (12)
C6	0.0410 (18)	0.0361 (16)	0.0477 (18)	−0.0001 (14)	−0.0151 (14)	−0.0082 (13)
C18	0.0363 (17)	0.0353 (16)	0.0441 (17)	−0.0041 (13)	−0.0130 (14)	0.0003 (13)
C14	0.0429 (18)	0.0354 (16)	0.0464 (18)	−0.0060 (14)	−0.0045 (14)	−0.0002 (13)
C5	0.0379 (17)	0.0352 (15)	0.0401 (16)	−0.0074 (13)	−0.0127 (13)	−0.0029 (12)
C17	0.0364 (17)	0.0402 (16)	0.0418 (17)	−0.0062 (13)	−0.0096 (13)	−0.0010 (13)
C3	0.0382 (17)	0.0336 (15)	0.0392 (16)	−0.0046 (13)	−0.0115 (13)	−0.0032 (12)
C19	0.0442 (19)	0.0400 (18)	0.0505 (19)	−0.0064 (15)	−0.0142 (15)	0.0027 (14)
C16	0.0373 (17)	0.0349 (15)	0.0441 (17)	−0.0058 (13)	−0.0100 (13)	−0.0011 (12)
C9	0.0439 (19)	0.0457 (18)	0.0437 (18)	−0.0001 (15)	−0.0122 (15)	−0.0091 (14)
C13	0.0429 (18)	0.0370 (17)	0.0478 (18)	−0.0055 (14)	−0.0069 (14)	−0.0124 (14)
C8	0.059 (2)	0.0508 (19)	0.0417 (17)	0.0031 (16)	−0.0212 (16)	−0.0084 (14)
C22	0.046 (2)	0.0473 (19)	0.0439 (18)	−0.0039 (15)	−0.0071 (15)	−0.0023 (14)
C23	0.0442 (18)	0.0386 (17)	0.0435 (17)	−0.0078 (14)	−0.0101 (15)	0.0016 (13)
C1	0.0331 (16)	0.0403 (16)	0.0373 (16)	−0.0069 (13)	−0.0087 (13)	−0.0024 (12)
C7	0.050 (2)	0.0436 (18)	0.0519 (19)	0.0031 (15)	−0.0271 (16)	−0.0030 (14)
C24	0.049 (2)	0.0476 (19)	0.060 (2)	−0.0124 (16)	−0.0070 (16)	0.0039 (15)
C12	0.0497 (19)	0.0449 (18)	0.0362 (16)	−0.0094 (15)	−0.0075 (14)	−0.0087 (13)
C32	0.0424 (19)	0.058 (2)	0.062 (2)	−0.0067 (16)	−0.0194 (16)	−0.0123 (16)
C21	0.062 (2)	0.0394 (18)	0.056 (2)	−0.0003 (16)	−0.0149 (18)	−0.0066 (15)
C28	0.092 (3)	0.078 (3)	0.0403 (19)	−0.040 (2)	−0.0183 (19)	0.0098 (17)
C31	0.044 (2)	0.058 (2)	0.058 (2)	−0.0082 (16)	−0.0097 (16)	0.0134 (16)
C20	0.057 (2)	0.0379 (18)	0.066 (2)	−0.0120 (16)	−0.0148 (18)	0.0027 (15)
C29	0.074 (3)	0.061 (2)	0.066 (2)	−0.0199 (19)	−0.018 (2)	−0.0195 (18)
C34	0.071 (3)	0.059 (2)	0.110 (3)	−0.029 (2)	−0.005 (2)	0.013 (2)
C27	0.114 (4)	0.090 (3)	0.064 (3)	0.029 (3)	−0.034 (3)	−0.038 (2)
C33	0.071 (3)	0.093 (3)	0.081 (3)	−0.014 (2)	−0.023 (2)	−0.034 (2)
C25	0.050 (2)	0.088 (3)	0.099 (3)	−0.002 (2)	−0.013 (2)	−0.025 (2)
C30	0.092 (3)	0.086 (3)	0.057 (2)	−0.038 (2)	−0.014 (2)	0.017 (2)
C35	0.101 (4)	0.042 (2)	0.145 (4)	0.001 (2)	−0.019 (3)	−0.018 (2)
C26	0.113 (4)	0.088 (3)	0.071 (3)	0.022 (3)	−0.058 (3)	−0.011 (2)
C36	0.064 (3)	0.151 (5)	0.086 (3)	−0.028 (3)	−0.001 (3)	−0.012 (3)
C15	0.0439 (18)	0.0403 (17)	0.0370 (16)	−0.0046 (14)	−0.0071 (14)	−0.0040 (13)
C38A	0.104 (4)	0.099 (5)	0.092 (4)	−0.017 (4)	−0.024 (3)	0.003 (4)
C39A	0.121 (6)	0.128 (5)	0.119 (5)	−0.027 (4)	−0.021 (4)	−0.005 (4)
O36A	0.113 (4)	0.130 (4)	0.142 (4)	−0.040 (4)	−0.018 (3)	0.024 (3)
C37A	0.078 (4)	0.081 (4)	0.077 (4)	−0.017 (4)	−0.013 (3)	0.011 (4)
C38B	0.096 (4)	0.090 (5)	0.085 (4)	−0.024 (4)	−0.026 (3)	0.005 (4)
C39B	0.132 (6)	0.132 (5)	0.124 (5)	−0.025 (4)	−0.021 (4)	−0.004 (4)
O36B	0.104 (4)	0.120 (4)	0.122 (4)	−0.053 (3)	−0.018 (3)	0.010 (3)
C37B	0.076 (4)	0.075 (4)	0.071 (4)	−0.019 (4)	−0.018 (3)	0.004 (4)

Geometric parameters (Å, º) top

O1—C6	1.386 (3)	C32—C33	1.515 (5)
O1—C25	1.411 (4)	C32—H32A	0.9700
O4—C11	1.377 (3)	C32—H32B	0.9700
O4—C28	1.420 (3)	C21—C20	1.378 (5)
O2—C7	1.372 (3)	C28—H28A	0.9600
O2—C26	1.403 (4)	C28—H28B	0.9600
O6—C14	1.379 (3)	C28—H28C	0.9600
O6—C30	1.408 (4)	C31—H31A	0.9600
O5—C13	1.371 (3)	C31—H31B	0.9600
O5—C29	1.415 (4)	C31—H31C	0.9600
O9—C22	1.391 (4)	C20—H20	0.9300
O9—C36	1.406 (5)	C29—H29A	0.9600
O7—C19	1.376 (4)	C29—H29B	0.9600
O7—C34	1.418 (4)	C29—H29C	0.9600
O3—C9	1.380 (3)	C34—H34A	0.9600
O3—C27	1.417 (4)	C34—H34B	0.9600
O8—C21	1.380 (4)	C34—H34C	0.9600
O8—C35	1.444 (5)	C27—H27A	0.9600
C10—C15	1.391 (4)	C27—H27B	0.9600
C10—C11	1.393 (4)	C27—H27C	0.9600
C10—C1	1.520 (4)	C33—H33A	0.9600
C11—C12	1.387 (4)	C33—H33B	0.9600
C2—C24	1.516 (4)	C33—H33C	0.9600
C2—C3	1.547 (4)	C25—H25A	0.9600
C2—C1	1.557 (4)	C25—H25B	0.9600
C2—H2	0.9800	C25—H25C	0.9600
C4—C9	1.389 (4)	C30—H30A	0.9600
C4—C5	1.391 (4)	C30—H30B	0.9600
C4—C3	1.519 (4)	C30—H30C	0.9600
C6—C5	1.380 (4)	C35—H35A	0.9600
C6—C7	1.393 (4)	C35—H35B	0.9600
C18—C23	1.388 (4)	C35—H35C	0.9600
C18—C19	1.396 (4)	C26—H26A	0.9600
C18—C17	1.523 (4)	C26—H26B	0.9600
C14—C15	1.381 (4)	C26—H26C	0.9600
C14—C13	1.396 (4)	C36—H36A	0.9600
C5—C1	1.506 (4)	C36—H36B	0.9600
C17—C32	1.538 (4)	C36—H36C	0.9600
C17—C16	1.553 (4)	C15—H15	0.9300
C17—H17	0.9800	C38A—C37A	1.426 (11)
C3—C16	1.550 (4)	C38A—H38A	0.9600
C3—H3	0.9800	C38A—H38B	0.9600
C19—C20	1.387 (4)	C38A—H38C	0.9600
C16—C31	1.527 (4)	C39A—C37A	1.456 (12)
C16—H16	0.9800	C39A—H39A	0.9600
C9—C8	1.389 (4)	C39A—H39B	0.9600
C13—C12	1.379 (4)	C39A—H39C	0.9600
C8—C7	1.383 (4)	O36A—C37A	1.196 (9)
C8—H8	0.9300	C38B—C37B	1.436 (11)
C22—C23	1.377 (4)	C38B—H38D	0.9600
C22—C21	1.394 (4)	C38B—H38E	0.9600
C23—H23	0.9300	C38B—H38F	0.9600
C1—H1	0.9800	C39B—C37B	1.459 (12)
C24—H24A	0.9600	C39B—H39D	0.9600
C24—H24B	0.9600	C39B—H39E	0.9600
C24—H24C	0.9600	C39B—H39F	0.9600
C12—H12	0.9300	O36B—C37B	1.203 (9)

C6—O1—C25	116.9 (2)	H32A—C32—H32B	107.6
C11—O4—C28	117.8 (2)	C20—C21—O8	124.7 (3)
C7—O2—C26	118.4 (3)	C20—C21—C22	119.4 (3)
C14—O6—C30	117.7 (2)	O8—C21—C22	115.8 (3)
C13—O5—C29	117.9 (2)	O4—C28—H28A	109.5
C22—O9—C36	113.6 (3)	O4—C28—H28B	109.5
C19—O7—C34	118.8 (3)	H28A—C28—H28B	109.5
C9—O3—C27	117.6 (2)	O4—C28—H28C	109.5
C21—O8—C35	116.2 (3)	H28A—C28—H28C	109.5
C15—C10—C11	117.0 (3)	H28B—C28—H28C	109.5
C15—C10—C1	123.2 (2)	C16—C31—H31A	109.5
C11—C10—C1	119.8 (2)	C16—C31—H31B	109.5
O4—C11—C12	123.2 (2)	H31A—C31—H31B	109.5
O4—C11—C10	115.5 (2)	C16—C31—H31C	109.5
C12—C11—C10	121.3 (3)	H31A—C31—H31C	109.5
C24—C2—C3	111.1 (2)	H31B—C31—H31C	109.5
C24—C2—C1	110.8 (2)	C21—C20—C19	120.5 (3)
C3—C2—C1	105.2 (2)	C21—C20—H20	119.7
C24—C2—H2	109.9	C19—C20—H20	119.7
C3—C2—H2	109.9	O5—C29—H29A	109.5
C1—C2—H2	109.9	O5—C29—H29B	109.5
C9—C4—C5	118.6 (2)	H29A—C29—H29B	109.5
C9—C4—C3	130.2 (3)	O5—C29—H29C	109.5
C5—C4—C3	110.9 (2)	H29A—C29—H29C	109.5
C5—C6—O1	118.6 (2)	H29B—C29—H29C	109.5
C5—C6—C7	118.7 (3)	O7—C34—H34A	109.5
O1—C6—C7	122.7 (2)	O7—C34—H34B	109.5
C23—C18—C19	116.5 (3)	H34A—C34—H34B	109.5
C23—C18—C17	121.5 (3)	O7—C34—H34C	109.5
C19—C18—C17	121.8 (3)	H34A—C34—H34C	109.5
O6—C14—C15	125.5 (3)	H34B—C34—H34C	109.5
O6—C14—C13	115.5 (3)	O3—C27—H27A	109.5
C15—C14—C13	119.0 (3)	O3—C27—H27B	109.5
C6—C5—C4	122.1 (2)	H27A—C27—H27B	109.5
C6—C5—C1	127.1 (3)	O3—C27—H27C	109.5
C4—C5—C1	110.7 (2)	H27A—C27—H27C	109.5
C18—C17—C32	110.8 (2)	H27B—C27—H27C	109.5
C18—C17—C16	114.7 (2)	C32—C33—H33A	109.5
C32—C17—C16	112.6 (2)	C32—C33—H33B	109.5
C18—C17—H17	106.0	H33A—C33—H33B	109.5
C32—C17—H17	106.0	C32—C33—H33C	109.5
C16—C17—H17	106.0	H33A—C33—H33C	109.5
C4—C3—C2	101.2 (2)	H33B—C33—H33C	109.5
C4—C3—C16	116.6 (2)	O1—C25—H25A	109.5
C2—C3—C16	110.8 (2)	O1—C25—H25B	109.5
C4—C3—H3	109.3	H25A—C25—H25B	109.5
C2—C3—H3	109.3	O1—C25—H25C	109.5
C16—C3—H3	109.3	H25A—C25—H25C	109.5
O7—C19—C20	122.0 (3)	H25B—C25—H25C	109.5
O7—C19—C18	116.7 (3)	O6—C30—H30A	109.5
C20—C19—C18	121.3 (3)	O6—C30—H30B	109.5
C31—C16—C3	113.2 (2)	H30A—C30—H30B	109.5
C31—C16—C17	113.7 (2)	O6—C30—H30C	109.5
C3—C16—C17	110.2 (2)	H30A—C30—H30C	109.5
C31—C16—H16	106.4	H30B—C30—H30C	109.5
C3—C16—H16	106.4	O8—C35—H35A	109.5
C17—C16—H16	106.4	O8—C35—H35B	109.5
O3—C9—C8	123.1 (3)	H35A—C35—H35B	109.5
O3—C9—C4	117.1 (2)	O8—C35—H35C	109.5
C8—C9—C4	119.8 (3)	H35A—C35—H35C	109.5
O5—C13—C12	124.5 (3)	H35B—C35—H35C	109.5
O5—C13—C14	115.9 (3)	O2—C26—H26A	109.5
C12—C13—C14	119.6 (3)	O2—C26—H26B	109.5
C7—C8—C9	120.8 (3)	H26A—C26—H26B	109.5
C7—C8—H8	119.6	O2—C26—H26C	109.5
C9—C8—H8	119.6	H26A—C26—H26C	109.5
C23—C22—O9	120.8 (3)	H26B—C26—H26C	109.5
C23—C22—C21	119.0 (3)	O9—C36—H36A	109.5
O9—C22—C21	120.2 (3)	O9—C36—H36B	109.5
C22—C23—C18	123.2 (3)	H36A—C36—H36B	109.5
C22—C23—H23	118.4	O9—C36—H36C	109.5
C18—C23—H23	118.4	H36A—C36—H36C	109.5
C5—C1—C10	114.4 (2)	H36B—C36—H36C	109.5
C5—C1—C2	101.8 (2)	C14—C15—C10	122.7 (3)
C10—C1—C2	114.6 (2)	C14—C15—H15	118.6
C5—C1—H1	108.6	C10—C15—H15	118.6
C10—C1—H1	108.6	O36A—C37A—C38A	122.5 (13)
C2—C1—H1	108.6	O36A—C37A—C39A	118.3 (12)
O2—C7—C8	124.0 (3)	C38A—C37A—C39A	119.2 (11)
O2—C7—C6	116.1 (3)	C37B—C38B—H38D	109.5
C8—C7—C6	119.9 (3)	C37B—C38B—H38E	109.5
C2—C24—H24A	109.5	H38D—C38B—H38E	109.5
C2—C24—H24B	109.5	C37B—C38B—H38F	109.5
H24A—C24—H24B	109.5	H38D—C38B—H38F	109.5
C2—C24—H24C	109.5	H38E—C38B—H38F	109.5
H24A—C24—H24C	109.5	C37B—C39B—H39D	109.5
H24B—C24—H24C	109.5	C37B—C39B—H39E	109.5
C13—C12—C11	120.4 (3)	H39D—C39B—H39E	109.5
C13—C12—H12	119.8	C37B—C39B—H39F	109.5
C11—C12—H12	119.8	H39D—C39B—H39F	109.5
C33—C32—C17	114.5 (3)	H39E—C39B—H39F	109.5
C33—C32—H32A	108.6	O36B—C37B—C38B	123.2 (12)
C17—C32—H32A	108.6	O36B—C37B—C39B	120.3 (13)
C33—C32—H32B	108.6	C38B—C37B—C39B	116.4 (11)
C17—C32—H32B	108.6

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C17—H17···O7	0.98	2.35	2.820 (3)	109
C25—H25B···O2	0.96	2.27	2.912 (5)	123
C28—H28A···Cg1ⁱ	0.96	2.93	3.565 (4)	125

Symmetry code: (i) −x+1, −y+1, −z.

Experimental details

Crystal data
Chemical formula	C₃₆H₄₈09·0.858C₃H₆O
M_r	674.57
Crystal system, space group	Triclinic, P1
Temperature (K)	298
a, b, c (Å)	8.9234 (10), 13.2672 (14), 16.3992 (18)
α, β, γ (°)	87.757 (2), 80.0900 (1), 76.0220 (1)
V (Å³)	1855.9 (4)
Z	2
Radiation type	Mo Kα
µ (mm⁻¹)	0.09
Crystal size (mm)	0.49 × 0.41 × 0.03

Data collection
Diffractometer	Bruker APEX area-detector diffractometer
Absorption correction	Multi-scan (SADABS; Bruker, 1998)
T_min, T_max	0.959, 0.997
No. of measured, independent and observed [I > 2σ(I)] reflections	9730, 6438, 3660
R_int	0.029
(sin θ/λ)_max (Å⁻¹)	0.595

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.055, 0.174, 1.01
No. of reflections	6438
No. of parameters	495
No. of restraints	84
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.40, −0.24

Computer programs: SMART (Bruker, 1998), SAINT (Bruker, 1998), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), SHELXTL (Sheldrick, 2008).

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C17—H17···O7	0.98	2.35	2.820 (3)	108.8
C25—H25B···O2	0.96	2.27	2.912 (5)	123.2
C28—H28A···Cg1ⁱ	0.96	2.93	3.565 (4)	125

Symmetry code: (i) −x+1, −y+1, −z.

Acknowledgements

We thank the National Natural Science Foundation of China (grant No. 20602010) and Hunan Provincial Natural Science Foundation of China (grant No. 06JJ50024) for financial support.

References

Belova, L. F., Alibekov, S. D., Baginskaya, A. I., Sokolov, S. Y., Pokrovskaya, G. V., Stikhin, V. A., Trumpe, T. & Gorodnyuk, T. I. (1985). Farmakol. Toksikol. 48, 17–20. CAS PubMed Web of Science Google Scholar
Bruker (1998). SADABS, SMART and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA. Google Scholar
Diaz, F., Munoz, H., Labarrios, F., Chamorro, G., Salazar, M., Morelos, M. E. & Tamariz, J. (1993). Med. Chem. Res. 3, 101–109. CAS Google Scholar
Hernandez, A., Lourdes Lopez, M., Chamorro, G. & Mendoza-Figueroa, T. (1993). Planta Med. 59, 121–124. CrossRef CAS PubMed Web of Science Google Scholar
Lemini, C., Mandoki, J. J., Cruz-Almanza, R. & Toscano, R. A. (1990). Acta Cryst. C46, 1542–1545. CSD CrossRef CAS Web of Science IUCr Journals Google Scholar
Menon, M. K. & Dandiya, P. C. (1967). J. Pharm. Pharmacol. 9, 170–175. CrossRef Google Scholar
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Xu, G., Liu, C., Zhang, W. & Zuo, G. (2009). Org. Prep. Proced. Int. 41, 153–156. CrossRef Google Scholar

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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

4,5,7-Trimeth­­oxy-2-methyl-3-(2,4,5-tri­meth­oxy­phen­yl)-1-[3-(2,4,5-tri­meth­oxy­phen­yl)pentan-2-yl]indane acetone 0.858-solvate

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Experimental

Crystal data

Data collection

Refinement

Supporting information

Acknowledgements

References

organic compounds

4,5,7-Trimethoxy-2-methyl-3-(2,4,5-trimethoxyphenyl)-1-[3-(2,4,5-trimethoxyphenyl)pentan-2-yl]indane acetone 0.858-solvate