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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 65| Part 10| October 2009| Page o2330
doi:10.1107/S1600536809033418

(−)-Istanbulin A

Matías López-Rodríguez,a Matías Reina,b D. M. Domínguez-Díaz,b V. Fajardoc and L. Villarroeld*

aInstituto de Bioorgánica "A. González", Universidad de La Laguna, Astrofísico Francisco Sánchez, 2, 38206 La Laguna, Tenerife, Spain, bInstituto de Productos Naturales y Agrobiología (IPNA-CSIC), Astrofísico Francisco Sánchez, 3, 38206 La Laguna, Tenerife, Spain, cFacultad de Ciencias, Universidad de Magallanes (UMAG), Punta Arenas, Chile, and dFacultad de Química y Biología, Universidad de Santiago de Chile, Chile
*Correspondence e-mail: malopez@ull.es

(Received 17 July 2009; accepted 21 August 2009; online 5 September 2009)

The title compound (systematic name: 9a-hydr­oxy-3,4a,5-trimethyl-4a,6,7,8a,9,9a-hexa­hydro-4H,5H-naphtho[2,3-b]furan-2,8-dione), C15H20O4, is a sesquiterpene lactone showing the typical eremophilanolide skeleton, which has been isolated from the plant Senecio candidans collected in the Chilean Magallanes region. The present study confirms the atomic connectivity assigned on the basis of 1H and 13C NMR spectroscopy, as well as the relative stereochemistry of the 4α-methyl,5α-methyl,8β-hydr­oxy,10β-H unit. The crystal structure is stabilized by inter­molecular O—H⋯O hydrogen bonds involving the hydr­oxy group as donor and the oxo group as acceptor, giving chains along the a axis. The absolute structure was not determined because of the lack of suitable anomalous scatters.

Related literature

For the biological activity of metabolites isolated from plants of the Senecio species, see: Ulubelen et al. (1971[Ulubelen, A., Öksüs, S., Samek, Z. & Holub, M. (1971). Tetrahedron Lett. 12, 4455-4456.]); Burgueño-Tapia et al. (2007[Burgueño-Tapia, E., González-Coloma, A., Martín-Benito, D. & Joseph-Nathan, P. Z. (2007). Z. Naturforsch. Teil C, 62,362-366.]); Domínguez et al. (2008[Domínguez, D. M., Reina, M., Villarroel, L., Fajardo, V. & González-Coloma, A. (2008). Z. Naturforsch. Teil C, 63, 837-842.]); Reina,González-Coloma, Domínguez-Díaz et al. (2006[Reina, M., González-Coloma, A., Domínguez-Díaz, D. M., Cabrera, R., Giménez-Mariño, C., López-Rodríguez, M. & Villarroel, L. (2006). J. Nat. Prod. 64, 6-11.]); Reina, González-Coloma, Gutiérrez et al. (2006[Reina, M., González-Coloma, A., Gutiérrez, C., Cabrera, R., López-Rodríguez, M., Fajardo, V. & Villarroel, L. (2006). Nat. Prod. Res. 20, 13-19.]).

[Scheme 1]

Experimental

Crystal data

  • C15H20O4

  • Mr = 264.31

  • Monoclinic, P 21

  • a = 7.432 (4) Å

  • b = 13.010 (6) Å

  • c = 8.161 (6) Å

  • β = 115.47 (4)°

  • V = 712.4 (8) Å3

  • Z = 2

  • Mo Kα radiation

  • μ = 0.09 mm−1

  • T = 293 K

  • 0.45 × 0.35 × 0.25 mm
Data collection

  • Enraf–Nonius KappaCCD diffractometer

  • Absorption correction: none

  • 4410 measured reflections

  • 1678 independent reflections

  • 1485 reflections with I > 2σ(I)

  • Rint = 0.018
Refinement

  • R[F2 > 2σ(F2)] = 0.038

  • wR(F2) = 0.095

  • S = 1.04

  • 1678 reflections

  • 186 parameters

  • 1 restraint

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.20 e Å−3

  • Δρmin = −0.12 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
O3—H3⋯O4i 0.90 (4) 1.87 (4) 2.750 (3) 164 (4)
Symmetry code: (i) x+1, y, z.

Data collection: COLLECT (Nonius, 2000[Nonius (2000). KappaCCD Server Software, Nonius BV, Delft, The Netherlands.]); cell refinement: SCALEPACK (Otwinowski & Minor, 1997[Otwinowski, Z. & Minor, W. (1997). Methods in Enzymology, Vol. 276, Macromolecular Crystallography, Part A, edited by C. W. Carter Jr & R. M. Sweet, pp. 307-326. New York: Academic Press.]); data reduction: SCALEPACK and DENZO (Otwinowski & Minor, 1997[Otwinowski, Z. & Minor, W. (1997). Methods in Enzymology, Vol. 276, Macromolecular Crystallography, Part A, edited by C. W. Carter Jr & R. M. Sweet, pp. 307-326. New York: Academic Press.]); program(s) used to solve structure: SIR97 (Altomare et al., 1999[Altomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Polidori, G. & Spagna, R. (1999). J. Appl. Cryst. 32, 115-119.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.] ); molecular graphics: PLATON (Spek, 2009[Spek, A. L. (2009). Acta Cryst. D65, 148-155.]); software used to prepare material for publication: WinGX (Farrugia,1999[Farrugia, L. J. (1999). J. Appl. Cryst. 32, 837-838.]).

Supporting information

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536809033418/hg2542sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536809033418/hg2542Isup2.hkl

checkCIF report


Comment top

The Senecio (Asteraceae) genus are widely distributed by the worldwide and the most studied constituents are sesquiterpenes with eremophilanolides and furanoeremophilanes skeleton, together with pyrrolizidine alkaloids. The chemical study of plants of the Senecio species has increased in the last few years because of the biological activity that shown the metabolites isolated from this natural sources: Reina, González-Coloma, Domínguez-Díaz et al. (2006); Reina, González-Coloma, Gutiérrez et al. (2006); Burgueño-Tapia et al. (2007); Domínguez et al. (2008).

As part of our ongoing study of Senecio genus from the chilean shouthern and Magallanes Region, in this work we report the isolation and the molecular and crystal structure determination of the title compound, which it is described for the first time as a metabolite for the Senecio genus. An Istanbulin A with optical rotation [α]D25 = + 81.5° was reported some years ago and its structure and stereochemistry determined by spectroscopic methods, but no X-ray analysys was performed (Ulubelen et al.,1971). The lack of suitable anomalous scatters did not allow us to reliably determine the absolute structure and that shown: 1-oxo-8β-hydroxy-10βH-eremophil-7(11)-en-12,8β-olide was chosen to be, on the basis of the negative optical rotation value: [α]D25 = - 68.7°, the opposite to that the previously reported compound.

The crystal structure is stabilized by intermolecular O—H···O hydrogen bonds in which are involved the hydroxyl group at C8 acting as donor and the oxo group at C1 as acceptor, giving chains along the a axis, through a C(7) graph-set motif.

Related literature top

For the biological activity of metabolites isolated from plants of the Senecio species, see: Ulubelen et al. (1971); Burgueño-Tapia et al. (2007); Domínguez et al. (2008); Reina,González-Coloma, Domínguez-Díaz et al. (2006); Reina, González-Coloma, Gutiérrez et al. (2006).

Experimental top

Senecio candidans DC. (Asteraceae) was collected from the south of Chile, at the Santa Maria River, Punta Arenas(XII Region), in april 2002 and authenticated by Professor E. Pisano. A voucher specimen (n° 3483) was deposited in the herbarium of Instituto de la Patagonia, Universidad de Magallanes, Punta Arenas (Chile).

Dried aerial parts of S.candidans (3.5 kg) was extracted in methanol at room temperature during a week to give a crude methanolic extract (224 g), 6.4% yield of dry plant weight. A portion of these crude methanolic extract (124 g) was chromatographed on a silica gel vacuum-liquid chromatography column (VLC), using a hexane-ethyl acetate-methanol gradient. The portion of the extract collected at the (hexane-ethyl acetate, 75:25) solvent polarity (2.7 g) was further purified by passage over Sephadex LH-20 (hexane-methylene chloride-methanol, 3:1:1), followed by different chromatographic techniques to give (-)-Istanbuline A: 1-oxo-8β-hydroxy-10βH-eremophil-7(11)-en-12,8β-olide (6.4 mg). The molecular formula C15H20O4 was deduced from its high resolution MS spectrum which shows a molecular ion at m/z=264.1357. Complete and unambiguous assignment of de all protons and carbon were established by analysis of the mono and bidimensional NMR experiments and comparison with the previously spectroscopic data reported for Istanbulin A (Ulubelen et al.,1971).

The absolute structure was not determined because of the lack of suitable anomalous scatters. However, the value of the measured optical rotation: [α]D25 = -68.7° allowed to us to choose that shown, as the opposite to that a previously described (+)-istanbulin: [α]D25 = +81.5°.

Refinement top

All H-atoms were located on sucessive difference-Fourier maps. The H-atom of the hydroxyl group was freely refined. and all other H atoms were constrained refined, with idealized geometries: C—H = 0.96(CH3), 0.97(CH2), 0.98(CH)Å. The lack of suitable anomalous scatters did not allow us to reliably determine the absolute structure and, therefore, the Friedel pairs were merged prior to the final refinement.

Computing details top

Data collection: COLLECT (Nonius, 2000); cell refinement: SCALEPACK (Otwinowski & Minor, 1997); data reduction: SCALEPACK and DENZO (Otwinowski & Minor, 1997); program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ); molecular graphics: PLATON (Spek, 2009); software used to prepare material for publication: WinGX (Farrugia,1999).

Figures top
[Figure 1] Fig. 1. Molecular structure of the title compund showing displacement ellipsoids at the 50% probability level.
[Figure 2] Fig. 2. A view of the hydrogen-bonding pattern. Hydrogen atoms not involved in the O—H···O interactions have been omitted.
9a-hydroxy-3,4a,5-trimethyl-4a,6,7,8a,9,9a-hexahydro-4H,5H- naphtho[2,3-b]furan-2,8-dione top
Crystal data top
C15H20O4F(000) = 284
Mr = 264.31Dx = 1.232 Mg m−3
Monoclinic, P21Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ybCell parameters from 297 reflections
a = 7.432 (4) Åθ = 4.3–23.7°
b = 13.010 (6) ŵ = 0.09 mm−1
c = 8.161 (6) ÅT = 293 K
β = 115.47 (4)°Block, colourless
V = 712.4 (8) Å30.45 × 0.35 × 0.25 mm
Z = 2
Data collection top
Enraf–Nonius KappaCCD
diffractometer		1485 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.018
Graphite monochromatorθmax = 27.5°, θmin = 6.4°
Detector resolution: 9 pixels mm-1h = −9→9
ϕ and ω scansk = −16→15
4410 measured reflectionsl = −10→10
1678 independent reflections
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.038Hydrogen site location: difference Fourier map
wR(F2) = 0.095H atoms treated by a mixture of independent and constrained refinement
S = 1.04 w = 1/[σ2(Fo2) + (0.0482P)2 + 0.0898P]
where P = (Fo2 + 2Fc2)/3
1678 reflections(Δ/σ)max = 0.001
186 parametersΔρmax = 0.20 e Å−3
1 restraintΔρmin = −0.12 e Å−3
Crystal data top
C15H20O4V = 712.4 (8) Å3
Mr = 264.31Z = 2
Monoclinic, P21Mo Kα radiation
a = 7.432 (4) ŵ = 0.09 mm−1
b = 13.010 (6) ÅT = 293 K
c = 8.161 (6) Å0.45 × 0.35 × 0.25 mm
β = 115.47 (4)°
Data collection top
Enraf–Nonius KappaCCD
diffractometer		1485 reflections with I > 2σ(I)
4410 measured reflectionsRint = 0.018
1678 independent reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0381 restraint
wR(F2) = 0.095H atoms treated by a mixture of independent and constrained refinement
S = 1.04Δρmax = 0.20 e Å−3
1678 reflectionsΔρmin = −0.12 e Å−3
186 parameters
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.4955 (3)0.50383 (14)0.8319 (2)0.0568 (5)
O20.5421 (4)0.5731 (2)0.6018 (3)0.0869 (7)
O30.6082 (2)0.37119 (15)1.04064 (19)0.0521 (4)
H30.713 (5)0.354 (3)1.018 (4)0.079 (9)*
O4−0.0560 (2)0.35876 (16)0.9801 (3)0.0635 (5)
C10.0324 (3)0.28290 (19)0.9675 (3)0.0456 (5)
C2−0.0216 (4)0.1763 (2)0.9971 (4)0.0635 (7)
H2A−0.14220.17781.01530.079 (9)*
H2B0.08440.14761.10530.073 (9)*
C3−0.0542 (4)0.1087 (2)0.8333 (4)0.0643 (7)
H3A−0.17590.12990.73120.074 (9)*
H3B−0.07130.03790.86150.059 (8)*
C40.1189 (4)0.11441 (18)0.7792 (3)0.0518 (6)
H40.23770.08910.88270.059 (7)*
C50.1632 (3)0.22659 (16)0.7435 (3)0.0375 (4)
C60.3567 (3)0.22904 (18)0.7137 (3)0.0448 (5)
H6A0.46020.18960.80840.057 (7)*
H6B0.33090.19770.59790.050 (7)*
C70.4259 (3)0.33673 (18)0.7168 (3)0.0422 (5)
C80.4541 (3)0.40177 (17)0.8797 (3)0.0412 (5)
C90.2648 (3)0.40183 (17)0.9078 (3)0.0407 (5)
H9A0.15890.43680.80760.036 (5)*
H9B0.28750.43771.01920.043 (6)*
C100.2059 (3)0.29068 (16)0.9181 (3)0.0372 (4)
H100.32000.25831.01700.044 (6)*
C110.4554 (3)0.3931 (2)0.5961 (3)0.0488 (6)
C120.5040 (4)0.4988 (3)0.6676 (4)0.0588 (6)
C130.4395 (4)0.3664 (3)0.4119 (3)0.0668 (8)
H13A0.55210.39400.39820.090*
H13B0.31900.39500.32070.090*
H13C0.43740.29300.39880.090*
C14−0.0102 (3)0.27228 (19)0.5782 (3)0.0512 (5)
H14A0.01730.34310.56480.090*
H14B−0.13030.26760.59470.090*
H14C−0.02660.23480.47130.090*
C150.0800 (5)0.0415 (2)0.6210 (5)0.0771 (9)
H15A0.18860.04540.58720.090*
H15B−0.04150.06070.51950.090*
H15C0.0685−0.02760.65690.090*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0612 (10)0.0542 (10)0.0633 (10)−0.0224 (8)0.0348 (8)−0.0122 (8)
O20.0968 (16)0.0837 (16)0.0944 (16)−0.0249 (13)0.0548 (14)0.0156 (13)
O30.0339 (7)0.0817 (12)0.0434 (7)−0.0078 (8)0.0194 (6)−0.0091 (8)
O40.0465 (9)0.0680 (12)0.0928 (12)−0.0034 (9)0.0460 (9)−0.0125 (10)
C10.0355 (10)0.0562 (14)0.0480 (11)−0.0048 (10)0.0208 (9)−0.0015 (11)
C20.0559 (14)0.0680 (18)0.0766 (17)−0.0052 (13)0.0378 (13)0.0159 (15)
C30.0604 (15)0.0452 (14)0.0848 (18)−0.0128 (12)0.0289 (14)0.0092 (14)
C40.0517 (12)0.0354 (11)0.0592 (13)0.0019 (10)0.0153 (11)0.0043 (11)
C50.0343 (9)0.0339 (10)0.0398 (9)0.0004 (8)0.0118 (8)−0.0005 (9)
C60.0463 (11)0.0476 (12)0.0440 (10)0.0054 (10)0.0228 (9)−0.0063 (10)
C70.0325 (9)0.0558 (13)0.0408 (10)−0.0020 (9)0.0183 (8)−0.0071 (10)
C80.0384 (10)0.0472 (12)0.0423 (10)−0.0099 (9)0.0213 (8)−0.0077 (9)
C90.0367 (9)0.0430 (12)0.0488 (11)−0.0050 (8)0.0244 (9)−0.0109 (9)
C100.0282 (8)0.0438 (11)0.0407 (10)0.0015 (8)0.0161 (7)0.0002 (9)
C110.0378 (10)0.0703 (16)0.0414 (10)−0.0015 (10)0.0201 (8)0.0010 (11)
C120.0495 (13)0.0745 (18)0.0584 (13)−0.0133 (12)0.0290 (11)0.0039 (13)
C130.0641 (14)0.099 (2)0.0423 (11)−0.0002 (16)0.0278 (11)0.0043 (14)
C140.0465 (12)0.0464 (13)0.0465 (11)0.0016 (10)0.0066 (9)0.0057 (11)
C150.089 (2)0.0412 (14)0.093 (2)−0.0098 (14)0.0316 (18)−0.0157 (14)
Geometric parameters (Å, º) top
O1—C121.371 (3)C6—H6A0.9700
O1—C81.454 (3)C6—H6B0.9700
O2—C121.198 (4)C7—C111.320 (3)
O3—C81.379 (3)C7—C81.512 (3)
O3—H30.90 (4)C8—C91.519 (3)
O4—C11.214 (3)C9—C101.524 (3)
C1—C21.493 (4)C9—H9A0.9700
C1—C101.511 (3)C9—H9B0.9700
C2—C31.530 (4)C10—H100.9800
C2—H2A0.9700C11—C121.477 (4)
C2—H2B0.9700C11—C131.497 (3)
C3—C41.532 (4)C13—H13A0.9600
C3—H3A0.9700C13—H13B0.9600
C3—H3B0.9700C13—H13C0.9600
C4—C151.526 (4)C14—H14A0.9600
C4—C51.551 (3)C14—H14B0.9600
C4—H40.9800C14—H14C0.9600
C5—C141.529 (3)C15—H15A0.9600
C5—C61.558 (3)C15—H15B0.9600
C5—C101.561 (3)C15—H15C0.9600
C6—C71.489 (3)
C12—O1—C8108.86 (19)O1—C8—C7103.91 (17)
C8—O3—H3108 (2)O3—C8—C9107.47 (17)
O4—C1—C2123.30 (19)O1—C8—C9110.88 (18)
O4—C1—C10121.5 (2)C7—C8—C9110.20 (16)
C2—C1—C10115.2 (2)C8—C9—C10108.33 (16)
C1—C2—C3110.2 (2)C8—C9—H9A110.0
C1—C2—H2A109.6C10—C9—H9A110.0
C3—C2—H2A109.6C8—C9—H9B110.0
C1—C2—H2B109.6C10—C9—H9B110.0
C3—C2—H2B109.6H9A—C9—H9B108.4
H2A—C2—H2B108.1C1—C10—C9112.13 (17)
C2—C3—C4112.8 (2)C1—C10—C5110.24 (17)
C2—C3—H3A109.0C9—C10—C5114.02 (16)
C4—C3—H3A109.0C1—C10—H10106.7
C2—C3—H3B109.0C9—C10—H10106.7
C4—C3—H3B109.0C5—C10—H10106.7
H3A—C3—H3B107.8C7—C11—C12108.2 (2)
C15—C4—C3109.7 (2)C7—C11—C13130.8 (3)
C15—C4—C5113.8 (2)C12—C11—C13120.9 (2)
C3—C4—C5111.89 (19)O2—C12—O1121.3 (3)
C15—C4—H4107.0O2—C12—C11129.7 (2)
C3—C4—H4107.0O1—C12—C11108.9 (2)
C5—C4—H4107.0C11—C13—H13A109.5
C14—C5—C4111.40 (18)C11—C13—H13B109.5
C14—C5—C6109.80 (18)H13A—C13—H13B109.5
C4—C5—C6109.48 (18)C11—C13—H13C109.5
C14—C5—C10111.15 (18)H13A—C13—H13C109.5
C4—C5—C10107.89 (17)H13B—C13—H13C109.5
C6—C5—C10106.99 (16)C5—C14—H14A109.5
C7—C6—C5110.60 (17)C5—C14—H14B109.5
C7—C6—H6A109.5H14A—C14—H14B109.5
C5—C6—H6A109.5C5—C14—H14C109.5
C7—C6—H6B109.5H14A—C14—H14C109.5
C5—C6—H6B109.5H14B—C14—H14C109.5
H6A—C6—H6B108.1C4—C15—H15A109.5
C11—C7—C6132.6 (2)C4—C15—H15B109.5
C11—C7—C8109.9 (2)H15A—C15—H15B109.5
C6—C7—C8117.24 (18)C4—C15—H15C109.5
O3—C8—O1109.53 (17)H15A—C15—H15C109.5
O3—C8—C7114.85 (19)H15B—C15—H15C109.5
O4—C1—C2—C3126.2 (3)O3—C8—C9—C10−72.0 (2)
C10—C1—C2—C3−53.2 (3)O1—C8—C9—C10168.34 (16)
C1—C2—C3—C451.1 (3)C7—C8—C9—C1053.8 (2)
C2—C3—C4—C15177.4 (2)O4—C1—C10—C96.0 (3)
C2—C3—C4—C5−55.3 (3)C2—C1—C10—C9−174.5 (2)
C15—C4—C5—C1459.4 (3)O4—C1—C10—C5−122.1 (2)
C3—C4—C5—C14−65.6 (3)C2—C1—C10—C557.3 (2)
C15—C4—C5—C6−62.2 (3)C8—C9—C10—C1173.39 (16)
C3—C4—C5—C6172.73 (19)C8—C9—C10—C5−60.4 (2)
C15—C4—C5—C10−178.3 (2)C14—C5—C10—C166.0 (2)
C3—C4—C5—C1056.6 (2)C4—C5—C10—C1−56.4 (2)
C14—C5—C6—C769.0 (2)C6—C5—C10—C1−174.11 (18)
C4—C5—C6—C7−168.42 (18)C14—C5—C10—C9−61.1 (2)
C10—C5—C6—C7−51.8 (2)C4—C5—C10—C9176.45 (16)
C5—C6—C7—C11−120.6 (2)C6—C5—C10—C958.7 (2)
C5—C6—C7—C853.2 (2)C6—C7—C11—C12173.9 (2)
C12—O1—C8—O3119.6 (2)C8—C7—C11—C12−0.3 (2)
C12—O1—C8—C7−3.5 (2)C6—C7—C11—C13−3.7 (4)
C12—O1—C8—C9−121.9 (2)C8—C7—C11—C13−177.9 (2)
C11—C7—C8—O3−117.3 (2)C8—O1—C12—O2−177.8 (2)
C6—C7—C8—O367.5 (2)C8—O1—C12—C113.5 (3)
C11—C7—C8—O12.3 (2)C7—C11—C12—O2179.5 (3)
C6—C7—C8—O1−172.85 (17)C13—C11—C12—O2−2.6 (4)
C11—C7—C8—C9121.1 (2)C7—C11—C12—O1−2.0 (3)
C6—C7—C8—C9−54.0 (2)C13—C11—C12—O1175.8 (2)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
O3—H3···O4i0.90 (4)1.87 (4)2.750 (3)164 (4)
Symmetry code: (i) x+1, y, z.

Experimental details

Crystal data
Chemical formulaC15H20O4
Mr264.31
Crystal system, space groupMonoclinic, P21
Temperature (K)293
a, b, c (Å)7.432 (4), 13.010 (6), 8.161 (6)
β (°) 115.47 (4)
V (Å3)712.4 (8)
Z2
Radiation typeMo Kα
µ (mm−1)0.09
Crystal size (mm)0.45 × 0.35 × 0.25
Data collection
DiffractometerEnraf–Nonius KappaCCD
diffractometer
Absorption correction–
No. of measured, independent and
observed [I > 2σ(I)] reflections		4410, 1678, 1485
Rint0.018
(sin θ/λ)max (Å−1)0.650
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.038, 0.095, 1.04
No. of reflections1678
No. of parameters186
No. of restraints1
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å−3)0.20, −0.12

Computer programs: COLLECT (Nonius, 2000), SCALEPACK (Otwinowski & Minor, 1997), SCALEPACK and DENZO (Otwinowski & Minor, 1997), SIR97 (Altomare et al., 1999), SHELXL97 (Sheldrick, 2008 ), PLATON (Spek, 2009), WinGX (Farrugia,1999).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
O3—H3···O4i0.90 (4)1.87 (4)2.750 (3)164 (4)
Symmetry code: (i) x+1, y, z.
 

References

First citationAltomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Polidori, G. & Spagna, R. (1999). J. Appl. Cryst. 32, 115–119.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationBurgueño-Tapia, E., González-Coloma, A., Martín-Benito, D. & Joseph-Nathan, P. Z. (2007). Z. Naturforsch. Teil C, 62,362–366.  Google Scholar
 First citationDomínguez, D. M., Reina, M., Villarroel, L., Fajardo, V. & González-Coloma, A. (2008). Z. Naturforsch. Teil C, 63, 837–842.  Google Scholar
 First citationFarrugia, L. J. (1999). J. Appl. Cryst. 32, 837–838.  CrossRef CAS IUCr Journals Google Scholar
 First citationNonius (2000). KappaCCD Server Software, Nonius BV, Delft, The Netherlands.  Google Scholar
 First citationOtwinowski, Z. & Minor, W. (1997). Methods in Enzymology, Vol. 276, Macromolecular Crystallography, Part A, edited by C. W. Carter Jr & R. M. Sweet, pp. 307–326. New York: Academic Press.  Google Scholar
 First citationReina, M., González-Coloma, A., Domínguez-Díaz, D. M., Cabrera, R., Giménez-Mariño, C., López-Rodríguez, M. & Villarroel, L. (2006). J. Nat. Prod. 64, 6–11.  Web of Science CSD CrossRef Google Scholar
 First citationReina, M., González-Coloma, A., Gutiérrez, C., Cabrera, R., López-Rodríguez, M., Fajardo, V. & Villarroel, L. (2006). Nat. Prod. Res. 20, 13–19.  Web of Science CSD CrossRef PubMed CAS Google Scholar
 First citationSheldrick, G. M. (2008). Acta Cryst. A64, 112–122.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationSpek, A. L. (2009). Acta Cryst. D65, 148–155.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationUlubelen, A., Öksüs, S., Samek, Z. & Holub, M. (1971). Tetrahedron Lett. 12, 4455–4456.  CrossRef Google Scholar

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ISSN: 2056-9890
Volume 65| Part 10| October 2009| Page o2330
doi:10.1107/S1600536809033418
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