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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 2| February 2010| Page o351
https://doi.org/10.1107/S1600536810000863

5α-Pregna-1,20-dien-3-one

Guang-ying Chen,a* Mei-Yan Wei,b Ni Tan,c Zhen Liud and Rui-Yun Yange

aHainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, People's Republic of China, bSchool of Pharmacy, Guangdong Medical College, Dongguan, Guangdong 523808, People's Republic of China, cSchool of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, People's Republic of China, dCollege of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471022, People's Republic of China, and eKey Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education, School of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, Guangxi 541004, People's Republic of China
*Correspondence e-mail: chgying123@163.com

(Received 21 December 2009; accepted 7 January 2010; online 13 January 2010)

The title compound, C21H30O, was isolated from the soft coral Sinularia sp. The mol­ecule contains four alicyclic rings, all trans-fused, among which three six-membered rings are in different distorted chair conformations while a five-membered ring assumes an envelope form.

Related literature

For general background to marine pregnanes isolated from marine organisms, see: Higgs & Faulkner (1977[Higgs, M. D. & Faulkner, D. J. (1977). Steroids, 30, 379-388.]); Blackman et al. (1985[Blackman, A. J., Heaton, A., Skelton, B. W. & White, A. H. (1985). Aust. J. Chem. A, 38, 565-573.]); Hooper & Davies-Coleman (1995[Hooper, G. J. & Davies-Coleman, M. T. (1995). Tetrahedron, 51, 9973-9984.]); Kittakoop et al. (1999[Kittakoop, P., Suttisri, R., Chaichantipyuth, C., Vethchagarun, S. & Suwanborirux, K. (1999). J. Nat. Prod. 62, 318-320.]); Li et al. (2009[Li, L., Wang, C. Y., Shao, C. L., Guo, Y. W., Li, G. Q., Sun, X. P., Han, L., Huang, H. & Guan, H. S. (2009). Helv. Chim. Acta, 92, 1495-1502.]); Yan et al. (2004[Yan, X. H., Guo, Y. W., Zhu, X. Z., Mollo, E. & Cimino, G. (2004). Youji Huaxue, 24, 1233-1238.], 2007[Yan, X. H., Jia, R., Shen, X. & Guo, Y. W. (2007). Nat. Prod. Res. Part A Struct. Synth. 21, 897-902.]); Zhang et al. (2005[Zhang, C. X., Lu, W. G., Yan, S. J., Su, J. Y. & Zeng, L. M. (2005). Zhongshan Daxue Xuebao Ziran Kexueban, 44, 134-136.]); Seo et al. (1995[Seo, Y., Jung, J. H., Rho, J. R., Shin, J. & Song, J. I. (1995). Tetrahedron, 51, 2497-2506.]).

[Scheme 1]

Experimental

Crystal data

  • C21H30O

  • Mr = 298.45

  • Orthorhombic, P 21 21 21

  • a = 7.2619 (13) Å

  • b = 10.998 (2) Å

  • c = 21.964 (4) Å

  • V = 1754.2 (6) Å3

  • Z = 4

  • Mo Kα radiation

  • μ = 0.07 mm−1

  • T = 293 K

  • 0.25 × 0.22 × 0.20 mm
Data collection

  • Bruker APEXII CCD diffractometer

  • Absorption correction: multi-scan (SADABS; Sheldrick, 1996[Sheldrick, G. M. (1996). SADABS. University of Göttingen, Germany.]) Tmin = 0.984, Tmax = 0.987

  • 7653 measured reflections

  • 1995 independent reflections

  • 1563 reflections with I > 2σ(I)

  • Rint = 0.053
Refinement

  • R[F2 > 2σ(F2)] = 0.051

  • wR(F2) = 0.114

  • S = 1.10

  • 1995 reflections

  • 201 parameters

  • H-atom parameters constrained

  • Δρmax = 0.13 e Å−3

  • Δρmin = −0.18 e Å−3

Data collection: APEX2 (Bruker, 2004[Bruker (2004). APEX2 and SAINT . Bruker AXS Inc., Madison, Wisconsin, USA.]); cell refinement: SAINT (Bruker, 2004[Bruker (2004). APEX2 and SAINT . Bruker AXS Inc., Madison, Wisconsin, USA.]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]) and DIAMOND (Brandenburg, 2006[Brandenburg, K. (2006). DIAMOND. Crystal Impact GbR, Bonn, Germany.]); software used to prepare material for publication: SHELXTL.

Supporting information

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S1600536810000863/gk2251sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536810000863/gk2251Isup2.hkl

checkCIF report


Comment top

Soft corals have been well recognized as marine organisms containing large quantities of secondary metabolites that exhibit various biological activities. In this regard, 5α-pregna-1,20-dien-3-one was firstly isolated as a marine natural product from an unknown coral (Higgs et al., 1977), subsequently from a soft coral of the genus Capnella (Blackman et al., 1985; Hooper et al., 1995), Scleronephthya pallida (Kittakoop et al., 1999), Scleronephthya sp. (Yan et al., 2004), Spongodes sp. (Yan et al., 2004; Yan et al., 2007), all of those belong to the family Nephtheidae. Furthermore, the title compound was also reported to be isolated from the family Alcyoniidae from two soft corals Sinularia papillosa (Zhang et al., 2005) and Alcyonium gracillimun(Seo et al., 1995). In course of our investigations of bioactive substances from marine organisms (Li et al., 2009), a soft coral Sinularia sp. which was collected from Sanya, was studied. In this paper, we describe the isolation, structure elucidation and crystal structure of the title compound.

The molecular structure of the title compound is shown in Fig. 1. The four fused rings are in different distorted conformations. Due to the C1=C2 double bond, ring A is highly distorted with a half-chair conformation. Rings B and C have slightly flattened chair conformations. Ring D assumes an unusual envelope conformation, probably induced by the vinyl substituent. Sstablization of the crystal structure is due only to weak van der Waals interactions.

Related literature top

For general background, see: Higgs & Faulkner (1977); Blackman et al. (1985); Hooper & Davies-Coleman (1995); Kittakoop et al. (1999); Li et al. (2009); Yan et al. (2004, 2007); Zhang et al. (2005); Seo et al. (1995).

Experimental top

The soft coral Sinularia sp. was collected by SCUBA diving off coral reef at a depth of 15–20 m at Sanya in Hainan Island, PR China, in June 2005. The sample was frozen immediately after collection. The species was identified by Professor Renlin Zou (South China Sea Institute of Oceanology, Chinese Academy of Sciences). The soft coral (800 g, wet weight) was homogenized and extracted with MeOH for three times at room temperature, and the MeOH extracts were combined and then concentrated under vacuo to give a dark brown residue (25.6 g). The residue was partitioned between H2O and EtOAc. The ethyl acetate fraction was subjected to column chromatography over silica gel and Sephadex LH-20 to give the pure title compound (54.9 mg). The crystalline compound was obtained through the slow evaporation of the ethyl acetate solution of the title compound.

Refinement top

All H atoms were positioned geometrically and treated as riding, with C—H bond lengths constrained to 0.93 Å (CH), 0.97 Å (CH2) 0.96 Å (methyl CH3), and with Uiso(H) = 1.2Ueq(C) or 1.5Ueq(methyl).

Structure description top

Soft corals have been well recognized as marine organisms containing large quantities of secondary metabolites that exhibit various biological activities. In this regard, 5α-pregna-1,20-dien-3-one was firstly isolated as a marine natural product from an unknown coral (Higgs et al., 1977), subsequently from a soft coral of the genus Capnella (Blackman et al., 1985; Hooper et al., 1995), Scleronephthya pallida (Kittakoop et al., 1999), Scleronephthya sp. (Yan et al., 2004), Spongodes sp. (Yan et al., 2004; Yan et al., 2007), all of those belong to the family Nephtheidae. Furthermore, the title compound was also reported to be isolated from the family Alcyoniidae from two soft corals Sinularia papillosa (Zhang et al., 2005) and Alcyonium gracillimun(Seo et al., 1995). In course of our investigations of bioactive substances from marine organisms (Li et al., 2009), a soft coral Sinularia sp. which was collected from Sanya, was studied. In this paper, we describe the isolation, structure elucidation and crystal structure of the title compound.

The molecular structure of the title compound is shown in Fig. 1. The four fused rings are in different distorted conformations. Due to the C1=C2 double bond, ring A is highly distorted with a half-chair conformation. Rings B and C have slightly flattened chair conformations. Ring D assumes an unusual envelope conformation, probably induced by the vinyl substituent. Sstablization of the crystal structure is due only to weak van der Waals interactions.

For general background, see: Higgs & Faulkner (1977); Blackman et al. (1985); Hooper & Davies-Coleman (1995); Kittakoop et al. (1999); Li et al. (2009); Yan et al. (2004, 2007); Zhang et al. (2005); Seo et al. (1995).

Computing details top

Data collection: APEX2 (Bruker, 2004); cell refinement: SAINT (Bruker, 2004); data reduction: SAINT (Bruker, 2004); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXS97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008) and DIAMOND (Brandenburg, 2006); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. View of the title molecular structure with atom numbering scheme and 30% probability displacement ellipsoids for non-hydrogen atoms.
5α-Pregna-1,20-dien-3-one top
Crystal data top
C21H30OF(000) = 656
Mr = 298.45Dx = 1.130 Mg m−3
Orthorhombic, P212121Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2abCell parameters from 7653 reflections
a = 7.2619 (13) Åθ = 2.1–26.0°
b = 10.998 (2) ŵ = 0.07 mm−1
c = 21.964 (4) ÅT = 293 K
V = 1754.2 (6) Å3Block, colorless
Z = 40.25 × 0.22 × 0.20 mm
Data collection top
Bruker APEXII CCD
diffractometer		1995 independent reflections
Radiation source: fine-focus sealed tube1563 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.053
Detector resolution: 0 pixels mm-1θmax = 26.0°, θmin = 2.1°
φ and ω scansh = −8→6
Absorption correction: multi-scan
(SADABS; Sheldrick, 1996)		k = −13→13
Tmin = 0.984, Tmax = 0.987l = −27→25
7653 measured reflections
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.051Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.114H-atom parameters constrained
S = 1.10 w = 1/[σ2(Fo2) + (0.0531P)2]
where P = (Fo2 + 2Fc2)/3
1995 reflections(Δ/σ)max < 0.001
201 parametersΔρmax = 0.13 e Å−3
0 restraintsΔρmin = −0.18 e Å−3
Crystal data top
C21H30OV = 1754.2 (6) Å3
Mr = 298.45Z = 4
Orthorhombic, P212121Mo Kα radiation
a = 7.2619 (13) ŵ = 0.07 mm−1
b = 10.998 (2) ÅT = 293 K
c = 21.964 (4) Å0.25 × 0.22 × 0.20 mm
Data collection top
Bruker APEXII CCD
diffractometer		1995 independent reflections
Absorption correction: multi-scan
(SADABS; Sheldrick, 1996)		1563 reflections with I > 2σ(I)
Tmin = 0.984, Tmax = 0.987Rint = 0.053
7653 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0510 restraints
wR(F2) = 0.114H-atom parameters constrained
S = 1.10Δρmax = 0.13 e Å−3
1995 reflectionsΔρmin = −0.18 e Å−3
201 parameters
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
C10.4468 (4)0.1678 (3)0.18505 (11)0.0607 (8)
H10.56130.13440.17600.073*
C20.4398 (5)0.2554 (3)0.22674 (13)0.0709 (10)
H20.54950.28150.24420.085*
C30.2683 (5)0.3124 (3)0.24637 (12)0.0684 (9)
C40.0964 (4)0.2700 (3)0.21577 (12)0.0602 (8)
H4A0.01080.33750.21270.072*
H4B0.03910.20750.24050.072*
C50.1328 (4)0.2193 (2)0.15234 (11)0.0470 (7)
H50.18220.28700.12840.056*
C6−0.0413 (4)0.1780 (3)0.11961 (11)0.0507 (7)
H6A−0.13280.24220.12100.061*
H6B−0.09180.10710.13990.061*
C70.0026 (4)0.1469 (2)0.05360 (11)0.0500 (7)
H7A−0.10750.11490.03440.060*
H7B0.03630.22100.03240.060*
C80.1565 (3)0.0555 (2)0.04637 (11)0.0417 (6)
H80.1119−0.02340.06100.050*
C90.3289 (3)0.0902 (2)0.08406 (11)0.0414 (6)
H90.37360.16670.06660.050*
C100.2826 (4)0.1193 (2)0.15166 (11)0.0446 (6)
C110.4847 (4)−0.0019 (2)0.07458 (11)0.0500 (7)
H11A0.4480−0.07960.09160.060*
H11B0.59320.02550.09640.060*
C120.5332 (4)−0.0188 (2)0.00707 (11)0.0477 (7)
H12A0.58360.0564−0.00890.057*
H12B0.6266−0.08140.00320.057*
C130.3649 (3)−0.0546 (2)−0.02996 (11)0.0430 (6)
C140.2141 (3)0.0410 (2)−0.01977 (11)0.0429 (6)
H140.26890.1190−0.03150.051*
C150.0723 (4)0.0120 (3)−0.06889 (11)0.0591 (8)
H15A0.00360.0842−0.08020.071*
H15B−0.0133−0.0498−0.05510.071*
C160.1885 (4)−0.0347 (3)−0.12272 (13)0.0706 (9)
H16A0.1441−0.1135−0.13600.085*
H16B0.18110.0215−0.15670.085*
C170.3882 (4)−0.0446 (3)−0.09989 (11)0.0528 (7)
H170.44840.0334−0.10830.063*
C180.3017 (4)−0.1838 (2)−0.01350 (13)0.0591 (8)
H18A0.4009−0.2398−0.02040.089*
H18B0.1985−0.2059−0.03840.089*
H18C0.2664−0.18630.02860.089*
C190.2221 (5)0.0030 (3)0.18588 (12)0.0617 (9)
H19A0.3250−0.05120.18950.093*
H19B0.1252−0.03630.16360.093*
H19C0.17850.02450.22570.093*
C200.5016 (5)−0.1414 (3)−0.12920 (12)0.0672 (9)
H200.4512−0.2189−0.13170.081*
C210.6668 (5)−0.1253 (4)−0.15167 (14)0.0843 (12)
H21A0.7218−0.0490−0.15000.101*
H21B0.7292−0.1903−0.16930.101*
O10.2658 (4)0.3879 (3)0.28688 (11)0.1084 (10)
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
C10.052 (2)0.083 (2)0.0466 (16)−0.0024 (18)−0.0062 (13)−0.0025 (15)
C20.061 (2)0.096 (3)0.0553 (18)−0.013 (2)−0.0124 (15)−0.0138 (18)
C30.079 (2)0.080 (2)0.0458 (16)−0.006 (2)−0.0011 (16)−0.0092 (16)
C40.064 (2)0.069 (2)0.0477 (17)0.0012 (17)0.0080 (15)−0.0002 (14)
C50.0485 (17)0.0497 (16)0.0428 (14)−0.0039 (14)0.0042 (12)0.0054 (11)
C60.0385 (16)0.0609 (17)0.0528 (15)0.0040 (15)0.0040 (12)0.0011 (13)
C70.0376 (15)0.0606 (17)0.0519 (15)0.0020 (15)−0.0075 (12)0.0021 (12)
C80.0352 (15)0.0439 (15)0.0461 (14)−0.0050 (13)−0.0032 (11)0.0046 (11)
C90.0386 (15)0.0432 (15)0.0425 (13)−0.0045 (13)−0.0013 (11)0.0055 (11)
C100.0430 (16)0.0523 (15)0.0386 (13)−0.0017 (14)−0.0032 (12)0.0046 (11)
C110.0402 (16)0.0606 (18)0.0493 (15)0.0031 (14)−0.0084 (12)−0.0012 (13)
C120.0408 (17)0.0443 (15)0.0580 (16)0.0010 (13)−0.0012 (12)−0.0028 (12)
C130.0400 (16)0.0423 (15)0.0468 (15)−0.0025 (13)−0.0002 (12)0.0019 (11)
C140.0392 (15)0.0463 (15)0.0432 (14)−0.0017 (13)−0.0053 (12)0.0050 (11)
C150.0547 (18)0.074 (2)0.0490 (17)0.0044 (17)−0.0140 (14)−0.0022 (14)
C160.072 (2)0.092 (2)0.0473 (16)0.003 (2)−0.0123 (16)−0.0092 (16)
C170.0557 (19)0.0532 (17)0.0494 (16)−0.0035 (16)0.0026 (13)−0.0025 (13)
C180.061 (2)0.0501 (17)0.0664 (17)−0.0050 (16)−0.0004 (15)0.0007 (14)
C190.071 (2)0.0659 (19)0.0482 (16)0.0009 (18)0.0012 (14)0.0170 (13)
C200.075 (2)0.077 (2)0.0502 (17)0.000 (2)0.0013 (16)−0.0143 (15)
C210.071 (3)0.108 (3)0.074 (2)0.013 (2)0.009 (2)−0.027 (2)
O10.114 (2)0.125 (2)0.0864 (17)0.003 (2)−0.0065 (16)−0.0523 (16)
Geometric parameters (Å, º) top
C1—C21.330 (4)C11—H11B0.9700
C1—C101.498 (4)C12—C131.520 (3)
C1—H10.9300C12—H12A0.9700
C2—C31.460 (5)C12—H12B0.9700
C2—H20.9300C13—C181.536 (4)
C3—O11.217 (3)C13—C141.534 (4)
C3—C41.493 (4)C13—C171.549 (3)
C4—C51.524 (4)C14—C151.525 (3)
C4—H4A0.9700C14—H140.9800
C4—H4B0.9700C15—C161.541 (4)
C5—C61.523 (4)C15—H15A0.9700
C5—C101.547 (4)C15—H15B0.9700
C5—H50.9800C16—C171.539 (4)
C6—C71.523 (4)C16—H16A0.9700
C6—H6A0.9700C16—H16B0.9700
C6—H6B0.9700C17—C201.492 (4)
C7—C81.512 (3)C17—H170.9800
C7—H7A0.9700C18—H18A0.9600
C7—H7B0.9700C18—H18B0.9600
C8—C141.520 (3)C18—H18C0.9600
C8—C91.549 (3)C19—H19A0.9600
C8—H80.9800C19—H19B0.9600
C9—C111.532 (3)C19—H19C0.9600
C9—C101.556 (3)C20—C211.309 (4)
C9—H90.9800C20—H200.9300
C10—C191.547 (4)C21—H21A0.9300
C11—C121.535 (4)C21—H21B0.9300
C11—H11A0.9700
C2—C1—C10124.4 (3)H11A—C11—H11B107.9
C2—C1—H1117.8C13—C12—C11111.3 (2)
C10—C1—H1117.8C13—C12—H12A109.4
C1—C2—C3123.2 (3)C11—C12—H12A109.4
C1—C2—H2118.4C13—C12—H12B109.4
C3—C2—H2118.4C11—C12—H12B109.4
O1—C3—C2121.5 (3)H12A—C12—H12B108.0
O1—C3—C4122.0 (3)C12—C13—C18110.7 (2)
C2—C3—C4116.5 (2)C12—C13—C14108.6 (2)
C3—C4—C5112.4 (2)C18—C13—C14112.7 (2)
C3—C4—H4A109.1C12—C13—C17115.1 (2)
C5—C4—H4A109.1C18—C13—C17109.4 (2)
C3—C4—H4B109.1C14—C13—C17100.0 (2)
C5—C4—H4B109.1C8—C14—C15120.8 (2)
H4A—C4—H4B107.9C8—C14—C13114.1 (2)
C6—C5—C4113.4 (2)C15—C14—C13103.6 (2)
C6—C5—C10111.5 (2)C8—C14—H14105.7
C4—C5—C10113.0 (2)C15—C14—H14105.7
C6—C5—H5106.1C13—C14—H14105.7
C4—C5—H5106.1C14—C15—C16104.1 (2)
C10—C5—H5106.1C14—C15—H15A110.9
C5—C6—C7110.0 (2)C16—C15—H15A110.9
C5—C6—H6A109.7C14—C15—H15B110.9
C7—C6—H6A109.7C16—C15—H15B110.9
C5—C6—H6B109.7H15A—C15—H15B109.0
C7—C6—H6B109.7C17—C16—C15106.8 (2)
H6A—C6—H6B108.2C17—C16—H16A110.4
C8—C7—C6113.8 (2)C15—C16—H16A110.4
C8—C7—H7A108.8C17—C16—H16B110.4
C6—C7—H7A108.8C15—C16—H16B110.4
C8—C7—H7B108.8H16A—C16—H16B108.6
C6—C7—H7B108.8C20—C17—C16115.5 (3)
H7A—C7—H7B107.7C20—C17—C13116.0 (2)
C7—C8—C14111.9 (2)C16—C17—C13103.0 (2)
C7—C8—C9112.2 (2)C20—C17—H17107.3
C14—C8—C9108.3 (2)C16—C17—H17107.3
C7—C8—H8108.1C13—C17—H17107.3
C14—C8—H8108.1C13—C18—H18A109.5
C9—C8—H8108.1C13—C18—H18B109.5
C11—C9—C8111.2 (2)H18A—C18—H18B109.5
C11—C9—C10115.2 (2)C13—C18—H18C109.5
C8—C9—C10112.7 (2)H18A—C18—H18C109.5
C11—C9—H9105.6H18B—C18—H18C109.5
C8—C9—H9105.6C10—C19—H19A109.5
C10—C9—H9105.6C10—C19—H19B109.5
C1—C10—C19106.4 (2)H19A—C19—H19B109.5
C1—C10—C5107.6 (2)C10—C19—H19C109.5
C19—C10—C5112.5 (2)H19A—C19—H19C109.5
C1—C10—C9111.6 (2)H19B—C19—H19C109.5
C19—C10—C9110.8 (2)C21—C20—C17124.9 (3)
C5—C10—C9107.9 (2)C21—C20—H20117.5
C9—C11—C12112.4 (2)C17—C20—H20117.5
C9—C11—H11A109.1C20—C21—H21A120.0
C12—C11—H11A109.1C20—C21—H21B120.0
C9—C11—H11B109.1H21A—C21—H21B120.0
C12—C11—H11B109.1

Experimental details

Crystal data
Chemical formulaC21H30O
Mr298.45
Crystal system, space groupOrthorhombic, P212121
Temperature (K)293
a, b, c (Å)7.2619 (13), 10.998 (2), 21.964 (4)
V (Å3)1754.2 (6)
Z4
Radiation typeMo Kα
µ (mm−1)0.07
Crystal size (mm)0.25 × 0.22 × 0.20
Data collection
DiffractometerBruker APEXII CCD
Absorption correctionMulti-scan
(SADABS; Sheldrick, 1996)
Tmin, Tmax0.984, 0.987
No. of measured, independent and
observed [I > 2σ(I)] reflections		7653, 1995, 1563
Rint0.053
(sin θ/λ)max (Å−1)0.617
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.051, 0.114, 1.10
No. of reflections1995
No. of parameters201
H-atom treatmentH-atom parameters constrained
Δρmax, Δρmin (e Å−3)0.13, −0.18

Computer programs: APEX2 (Bruker, 2004), SAINT (Bruker, 2004), SHELXS97 (Sheldrick, 2008), SHELXTL (Sheldrick, 2008) and DIAMOND (Brandenburg, 2006), SHELXTL (Sheldrick, 2008).

 

Acknowledgements

The authors acknowledge financial support from the National Natural Science Foundation of China (grant No. 20862005), the Program for New Century Excellent Talents in Universities (grant No. NCET-08-0656), the Youthful Fund of Guangdong Medical College (grant No. XQ0511) and the Open Research Fund Program of the Key Laboratory of Marine Drugs (Ocean University of China), the Ministry of Education [grant No. KLMD (OUC) 200801].

References

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ISSN: 2056-9890
Volume 66| Part 2| February 2010| Page o351
https://doi.org/10.1107/S1600536810000863
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