Issue contents
Download PDF of article
Download CIF
3D view
Navigation
Highlighting
Dictionary of Crystallography reference
IUPAC Gold Book reference
more ...
Download citation
FormatBIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Plain Text
share
Previous article
Next article
Previous article
Issue contents
Download PDF of article
Download CIF
3D view
Navigation
Highlighting
Dictionary of Crystallography reference
IUPAC Gold Book reference
more ...
Download citation
FormatBIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Plain Text
share
Next article

organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 2| February 2010| Page o259
https://doi.org/10.1107/S1600536809055081

Ethyl 3-methyl-4-oxo-4,5-di­hydro-1H-pyrrolo[2,3-d]pyridazine-2-carboxyl­ate

Shi-Quan Chen,a Kai Jiangb and Shi-Fan Wangc,a*

aKey Laboratory of Tropical Biological Resources of the Ministry of Education, Hainan University, Haikou 570228, People's Republic of China, bExperimental Teaching Center of Marine Biology, Hainan University, Haikou 570228, People's Republic of China, and cSchool of Ocean, Hainan University, Haikou 570228, People's Republic of China
*Correspondence e-mail: wangsf777@gmail.com

(Received 18 December 2009; accepted 22 December 2009; online 9 January 2010)

The title compound, C10H11N3O3, was synthesized by the reaction of 3,5-bis­(ethoxy­carbon­yl)-2-formyl-4-methyl-1H-pyrrole and hydrazine hydrate. The angle between the pyrrole ring and the pyridazinone ring is 0.93 (9)°. In the crystal, inter­molecular N—H⋯O and N—H⋯N hydrogen-bond inter­actions link the mol­ecules into a two-dimensional network.

Related literature

For the biological activity of pyrrolopyridazine compounds, see: Chen et al. (2006[Chen, Z., Kim, S. H., Barbosa, S. A., Huynh, T., Tortolani, D. R., Leavitt, K. J., Wei, D. D., Manne, V., Ricca, C. S., Gullo-Brown, J., Poss, M. A., Vaccaro, W. & Salvati, M. E. (2006). Bioorg. Med. Chem. Lett. 16, 628-632.]); Hu et al. (2004[Hu, T., Stearns, B. A., Campbell, B. T., Arruda, J. M., Chen, C., Aiyar, J., Bezverkov, R. E., Santini, A., Schaffhauser, H., Liu, W., Venkatraman, S. & Munoz, B. (2004). Bioorg. Med. Chem. Lett. 14, 2031-2034.]); Swamy et al. (2005[Swamy, K. M. K., Park, M. S., Han, S. J., Kim, S. K., Kim, J. H., Lee, C., Bang, H., Kim, Y., Kim, S.-J. & Yoon, J. (2005). Tetrahedron, 61, 10227-10234.]). For bond-length data, see Allen et al. (1987[Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1-19.]).

[Scheme 1]

Experimental

Crystal data

  • C10H11N3O3

  • Mr = 221.22

  • Monoclinic, P 21 /c

  • a = 8.0030 (16) Å

  • b = 9.774 (2) Å

  • c = 13.370 (3) Å

  • β = 90.17 (3)°

  • V = 1045.8 (4) Å3

  • Z = 4

  • Mo Kα radiation

  • μ = 0.11 mm−1

  • T = 295 K

  • 0.40 × 0.26 × 0.06 mm
Data collection

  • Bruker SMART CCD area-detector diffractometer

  • Absorption correction: multi-scan (SADABS; Sheldrick, 1996[Sheldrick, G. M. (1996). SADABS. University of Göttingen, Germany.]) Tmin = 0.959, Tmax = 0.994

  • 6834 measured reflections

  • 2045 independent reflections

  • 1676 reflections with I > 2σ(I)

  • Rint = 0.031
Refinement

  • R[F2 > 2σ(F2)] = 0.044

  • wR(F2) = 0.120

  • S = 1.06

  • 2045 reflections

  • 156 parameters

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.27 e Å−3

  • Δρmin = −0.21 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
N3—H3⋯O1i 0.90 (3) 1.90 (3) 2.804 (2) 175 (2)
N1—H1⋯N2ii 0.86 (2) 2.08 (2) 2.925 (2) 166.2 (17)
Symmetry codes: (i) -x, -y, -z+2; (ii) [-x, y+{\script{1\over 2}}, -z+{\script{3\over 2}}].

Data collection: SMART (Bruker 2002[Bruker (2002). SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.]); cell refinement: SAINT (Bruker 2002[Bruker (2002). SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: PLATON (Spek, 2009[Spek, A. L. (2009). Acta Cryst. D65, 148-155.]); software used to prepare material for publication: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]).

Supporting information

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S1600536809055081/sj2715sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536809055081/sj2715Isup2.hkl

checkCIF report


Comment top

Pyridazine and its derivatives play an important role play an important role in medicine and as pesticides. One of the main techniques to synthesize pyridazines is to react 1,4-dicarbonyl compounds with hydrazine hydrate. Recently, the synthesis of pyrrolopyridazine compounds has aroused great interest because of their significant biological activity (Chen et al., 2006; Hu et al., 2004; Swamy et al., 2005). As part of our work to develop new types of pyrrolopyridazine compounds with potential biological activity, we report here the synthesis and structure of the title compound (1). In the molecule of compound (1), the torsion angles are N1—C1—C2—C3 179.21 (14) and N1—C1—C2—C5 0.20 (18)°. The dihedral angle between the pyrrole and pyridazinone rings is 0.93 (9)°, an indication that the pyrrolopyridazine system is reasonably planar. The C4═N2 and C3═O1 bond lengths in the molecule are 1.291 (2) and 1.2397 (19)°, respectively, showing their double-bond character (Allen et al., 1987). In the crystal structure, N—H···O and N—H···N hydrogen bonds form a two-dimensional network structure, Fig. 2.

Related literature top

For the biological activity of pyrrolopyridazine compounds, see: Chen et al. (2006); Hu et al. (2004); Swamy et al. (2005). For bond-length data, see Allen et al. (1987).

Experimental top

2.39 g (10 mmol) of the 3,5-bis(ethoxycarbonyl)-2,4- dimethyl-1(H)-pyrrole was added to a mixed solvent of 60 ml THF and 60 ml glacial acetic acid at room temperature under stirring until all of the solid was dissolved. Then, 60 ml water and 21.93 g (40 mmol) cerous ammonium nitrate (CAN) were added consecutively and the mixture stirred at room temperature for 1.5 h until the reaction was complete. The reaction mixture was poured into ice water and the white solid was separated (2.13 g, 84%). Recrystallization of the white solid from ethanol gave the compound 3,5-bis(ethoxycarbonyl)-2-formyl-4-methyl-1(H)-pyrrole.

An aqueous solution of hydrazine hydrate (80%, 0.5 ml) was added into a solution of 3,5-bis(ethoxycarbonyl)-2-formyl-4-methyl- 1(H)-pyrrole (0.25 g, 1.0 mmol) in glacial acetic acid (20 ml) under stirring at room temperature. The reaction mixture was refluxed for 3 h till the reaction was complete. The reaction mixture was evaporated to remove the solvent of water and acetic acid at reduced pressure to yield the title compound (1) as a white solid (0.18 g, 82%). Recrystallization of the white solid from hot ethanol yielded colorless plate-like crystals suitable for X-ray diffraction analysis.

Refinement top

The H atoms bound to N1 and N3 were located in a difference Fourier map and refined freely with isotropic displacement parameters. All other H atoms were visible in difference maps and were subsequently treated as riding atoms with distances C—H = 0.93 - 0.97 Å. Uiso(H) was set equal to xUeq(parent atom), where x = 1.2 - 1.5.

Structure description top

Pyridazine and its derivatives play an important role play an important role in medicine and as pesticides. One of the main techniques to synthesize pyridazines is to react 1,4-dicarbonyl compounds with hydrazine hydrate. Recently, the synthesis of pyrrolopyridazine compounds has aroused great interest because of their significant biological activity (Chen et al., 2006; Hu et al., 2004; Swamy et al., 2005). As part of our work to develop new types of pyrrolopyridazine compounds with potential biological activity, we report here the synthesis and structure of the title compound (1). In the molecule of compound (1), the torsion angles are N1—C1—C2—C3 179.21 (14) and N1—C1—C2—C5 0.20 (18)°. The dihedral angle between the pyrrole and pyridazinone rings is 0.93 (9)°, an indication that the pyrrolopyridazine system is reasonably planar. The C4═N2 and C3═O1 bond lengths in the molecule are 1.291 (2) and 1.2397 (19)°, respectively, showing their double-bond character (Allen et al., 1987). In the crystal structure, N—H···O and N—H···N hydrogen bonds form a two-dimensional network structure, Fig. 2.

For the biological activity of pyrrolopyridazine compounds, see: Chen et al. (2006); Hu et al. (2004); Swamy et al. (2005). For bond-length data, see Allen et al. (1987).

Computing details top

Data collection: SMART (Bruker 2002); cell refinement: SAINT (Bruker 2002); data reduction: SAINT (Bruker 2002); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: PLATON (Spek, 2009); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. The structure of the title compound (1), showing 50% probability displacement ellipsoids and the atom-numbering scheme.
[Figure 2] Fig. 2. A packing diagram of compound (1) showing the chain of molecules linked by N3–H3···O1 and N1–H1···N2 hydrogen bonds. Hydrogen bonds are shown as dashed lines.
Ethyl 3-methyl-4-oxo-4,5-dihydro-1H- pyrrolo[2,3-d]pyridazine-2-carboxylate top
Crystal data top
C10H11N3O3F(000) = 464
Mr = 221.22Dx = 1.405 Mg m−3
Monoclinic, P21/cMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybcCell parameters from 7501 reflections
a = 8.0030 (16) Åθ = 2.6–26.4°
b = 9.774 (2) ŵ = 0.11 mm−1
c = 13.370 (3) ÅT = 295 K
β = 90.17 (3)°Plate, colourless
V = 1045.8 (4) Å30.40 × 0.26 × 0.06 mm
Z = 4
Data collection top
Bruker SMART CCD area-detector
diffractometer		2045 independent reflections
Radiation source: fine-focus sealed tube1676 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.031
φ and ω scansθmax = 26.0°, θmin = 2.6°
Absorption correction: multi-scan
(SADABS; Sheldrick, 1996)		h = −9→9
Tmin = 0.959, Tmax = 0.994k = −11→12
6834 measured reflectionsl = −16→15
Refinement top
Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.044H atoms treated by a mixture of independent and constrained refinement
wR(F2) = 0.120 w = 1/[σ2(Fo2) + (0.0631P)2 + 0.2196P]
where P = (Fo2 + 2Fc2)/3
S = 1.06(Δ/σ)max < 0.001
2045 reflectionsΔρmax = 0.27 e Å−3
156 parametersΔρmin = −0.21 e Å−3
0 restraintsExtinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methodsExtinction coefficient: 0.007 (2)
Crystal data top
C10H11N3O3V = 1045.8 (4) Å3
Mr = 221.22Z = 4
Monoclinic, P21/cMo Kα radiation
a = 8.0030 (16) ŵ = 0.11 mm−1
b = 9.774 (2) ÅT = 295 K
c = 13.370 (3) Å0.40 × 0.26 × 0.06 mm
β = 90.17 (3)°
Data collection top
Bruker SMART CCD area-detector
diffractometer		2045 independent reflections
Absorption correction: multi-scan
(SADABS; Sheldrick, 1996)		1676 reflections with I > 2σ(I)
Tmin = 0.959, Tmax = 0.994Rint = 0.031
6834 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0440 restraints
wR(F2) = 0.120H atoms treated by a mixture of independent and constrained refinement
S = 1.06Δρmax = 0.27 e Å−3
2045 reflectionsΔρmin = −0.21 e Å−3
156 parameters
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
C10.0960 (2)0.38216 (17)0.86245 (11)0.0291 (4)
C20.14214 (19)0.33040 (17)0.95543 (11)0.0277 (4)
C30.0970 (2)0.19196 (17)0.97885 (11)0.0295 (4)
C40.0078 (2)0.30214 (18)0.79200 (12)0.0348 (4)
H2−0.02090.33950.73030.042*
C50.22621 (19)0.43535 (17)1.00880 (11)0.0287 (4)
C60.2266 (2)0.54646 (17)0.94508 (11)0.0293 (4)
C70.2897 (2)0.68717 (18)0.95437 (12)0.0324 (4)
C80.4347 (2)0.8457 (2)1.05488 (15)0.0473 (5)
H8A0.35000.91501.04360.057*
H8B0.52470.86021.00760.057*
C90.4995 (3)0.8551 (3)1.15900 (17)0.0665 (7)
H9A0.58310.78601.16940.100*
H9B0.40940.84141.20520.100*
H9C0.54780.94381.16960.100*
C100.2976 (2)0.4242 (2)1.11193 (12)0.0380 (4)
H10A0.22330.46701.15870.057*
H10B0.40430.46901.11420.057*
H10C0.31110.32951.12910.057*
N10.14838 (18)0.51266 (15)0.85690 (10)0.0318 (4)
N2−0.03348 (19)0.17759 (15)0.81245 (10)0.0362 (4)
N30.01190 (19)0.12734 (16)0.90363 (10)0.0349 (4)
O10.12783 (16)0.13034 (12)1.05782 (8)0.0397 (4)
O20.27522 (18)0.77051 (14)0.88893 (10)0.0506 (4)
O30.36361 (16)0.71015 (13)1.04147 (9)0.0409 (4)
H10.132 (2)0.565 (2)0.8057 (15)0.038 (5)*
H3−0.028 (3)0.042 (3)0.9145 (16)0.067 (7)*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
C10.0348 (9)0.0251 (9)0.0274 (8)0.0005 (7)−0.0006 (6)0.0008 (7)
C20.0313 (8)0.0261 (9)0.0256 (8)0.0013 (7)−0.0007 (6)0.0005 (7)
C30.0342 (9)0.0275 (9)0.0268 (8)−0.0004 (7)−0.0005 (6)0.0017 (7)
C40.0503 (10)0.0287 (10)0.0253 (8)−0.0019 (8)−0.0054 (7)0.0011 (7)
C50.0299 (8)0.0271 (9)0.0290 (8)0.0013 (6)−0.0012 (6)−0.0003 (7)
C60.0321 (8)0.0273 (9)0.0286 (8)−0.0002 (7)−0.0028 (6)−0.0013 (7)
C70.0347 (9)0.0285 (10)0.0340 (9)−0.0017 (7)−0.0022 (7)−0.0007 (7)
C80.0492 (11)0.0365 (12)0.0562 (12)−0.0114 (9)−0.0071 (9)−0.0098 (9)
C90.0655 (14)0.0758 (18)0.0581 (14)−0.0170 (13)−0.0081 (11)−0.0236 (13)
C100.0447 (10)0.0367 (11)0.0325 (9)−0.0025 (8)−0.0098 (7)0.0021 (8)
N10.0432 (8)0.0254 (8)0.0268 (7)−0.0024 (6)−0.0058 (6)0.0050 (6)
N20.0515 (9)0.0298 (9)0.0272 (7)−0.0048 (7)−0.0059 (6)−0.0008 (6)
N30.0502 (9)0.0255 (9)0.0290 (7)−0.0063 (6)−0.0053 (6)0.0023 (6)
O10.0569 (8)0.0305 (7)0.0317 (7)−0.0077 (6)−0.0101 (5)0.0078 (5)
O20.0723 (10)0.0319 (8)0.0475 (8)−0.0113 (6)−0.0173 (7)0.0092 (6)
O30.0514 (8)0.0324 (8)0.0389 (7)−0.0092 (6)−0.0101 (6)−0.0006 (5)
Geometric parameters (Å, º) top
C1—N11.345 (2)C7—O31.324 (2)
C1—C21.391 (2)C8—O31.453 (2)
C1—C41.412 (2)C8—C91.487 (3)
C2—C51.418 (2)C8—H8A0.9700
C2—C31.435 (2)C8—H8B0.9700
C3—O11.2396 (19)C9—H9A0.9600
C3—N31.368 (2)C9—H9B0.9600
C4—N21.291 (2)C9—H9C0.9600
C4—H20.9300C10—H10A0.9600
C5—C61.380 (2)C10—H10B0.9600
C5—C101.495 (2)C10—H10C0.9600
C6—N11.374 (2)N1—H10.86 (2)
C6—C71.470 (2)N2—N31.3626 (19)
C7—O21.201 (2)N3—H30.90 (3)
N1—C1—C2108.20 (14)O3—C8—H8B110.1
N1—C1—C4130.09 (15)C9—C8—H8B110.1
C2—C1—C4121.71 (16)H8A—C8—H8B108.4
C1—C2—C5108.11 (15)C8—C9—H9A109.5
C1—C2—C3118.14 (14)C8—C9—H9B109.5
C5—C2—C3133.74 (14)H9A—C9—H9B109.5
O1—C3—N3119.96 (16)C8—C9—H9C109.5
O1—C3—C2126.47 (15)H9A—C9—H9C109.5
N3—C3—C2113.57 (14)H9B—C9—H9C109.5
N2—C4—C1120.59 (15)C5—C10—H10A109.5
N2—C4—H2119.7C5—C10—H10B109.5
C1—C4—H2119.7H10A—C10—H10B109.5
C6—C5—C2105.10 (14)C5—C10—H10C109.5
C6—C5—C10128.68 (15)H10A—C10—H10C109.5
C2—C5—C10126.22 (15)H10B—C10—H10C109.5
N1—C6—C5109.79 (15)C1—N1—C6108.79 (14)
N1—C6—C7116.94 (14)C1—N1—H1123.8 (13)
C5—C6—C7133.26 (15)C6—N1—H1127.4 (13)
O2—C7—O3124.61 (16)C4—N2—N3117.50 (14)
O2—C7—C6122.72 (16)N2—N3—C3128.49 (16)
O3—C7—C6112.68 (14)N2—N3—H3112.6 (14)
O3—C8—C9107.89 (17)C3—N3—H3118.8 (14)
O3—C8—H8A110.1C7—O3—C8115.92 (14)
C9—C8—H8A110.1
N1—C1—C2—C50.20 (18)C10—C5—C6—C7−1.4 (3)
C4—C1—C2—C5−179.24 (15)N1—C6—C7—O2−0.1 (3)
N1—C1—C2—C3179.22 (14)C5—C6—C7—O2−178.97 (18)
C4—C1—C2—C3−0.2 (2)N1—C6—C7—O3−179.76 (14)
C1—C2—C3—O1−179.84 (16)C5—C6—C7—O31.3 (3)
C5—C2—C3—O1−1.1 (3)C2—C1—N1—C6−0.42 (18)
C1—C2—C3—N30.1 (2)C4—C1—N1—C6178.97 (17)
C5—C2—C3—N3178.82 (16)C5—C6—N1—C10.49 (19)
N1—C1—C4—N2−179.01 (17)C7—C6—N1—C1−178.65 (14)
C2—C1—C4—N20.3 (3)C1—C4—N2—N3−0.3 (2)
C1—C2—C5—C60.09 (18)C4—N2—N3—C30.2 (3)
C3—C2—C5—C6−178.72 (17)O1—C3—N3—N2179.87 (16)
C1—C2—C5—C10−179.86 (15)C2—C3—N3—N2−0.1 (2)
C3—C2—C5—C101.3 (3)O2—C7—O3—C8−1.8 (3)
C2—C5—C6—N1−0.35 (18)C6—C7—O3—C8177.84 (15)
C10—C5—C6—N1179.60 (15)C9—C8—O3—C7175.68 (16)
C2—C5—C6—C7178.60 (17)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N3—H3···O1i0.90 (3)1.90 (3)2.804 (2)175 (2)
N1—H1···N2ii0.86 (2)2.08 (2)2.925 (2)166.2 (17)
Symmetry codes: (i) −x, −y, −z+2; (ii) −x, y+1/2, −z+3/2.

Experimental details

Crystal data
Chemical formulaC10H11N3O3
Mr221.22
Crystal system, space groupMonoclinic, P21/c
Temperature (K)295
a, b, c (Å)8.0030 (16), 9.774 (2), 13.370 (3)
β (°) 90.17 (3)
V (Å3)1045.8 (4)
Z4
Radiation typeMo Kα
µ (mm−1)0.11
Crystal size (mm)0.40 × 0.26 × 0.06
Data collection
DiffractometerBruker SMART CCD area-detector
Absorption correctionMulti-scan
(SADABS; Sheldrick, 1996)
Tmin, Tmax0.959, 0.994
No. of measured, independent and
observed [I > 2σ(I)] reflections		6834, 2045, 1676
Rint0.031
(sin θ/λ)max (Å−1)0.617
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.044, 0.120, 1.06
No. of reflections2045
No. of parameters156
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å−3)0.27, −0.21

Computer programs: SMART (Bruker 2002), SAINT (Bruker 2002), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), PLATON (Spek, 2009), SHELXTL (Sheldrick, 2008).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N3—H3···O1i0.90 (3)1.90 (3)2.804 (2)175 (2)
N1—H1···N2ii0.86 (2)2.08 (2)2.925 (2)166.2 (17)
Symmetry codes: (i) −x, −y, −z+2; (ii) −x, y+1/2, −z+3/2.
 

Acknowledgements

This research was supported financially by the National Natural Science Foundation of China (30660215).

References

First citationAllen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1–19.  CSD CrossRef Web of Science Google Scholar
 First citationBruker (2002). SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.  Google Scholar
 First citationChen, Z., Kim, S. H., Barbosa, S. A., Huynh, T., Tortolani, D. R., Leavitt, K. J., Wei, D. D., Manne, V., Ricca, C. S., Gullo-Brown, J., Poss, M. A., Vaccaro, W. & Salvati, M. E. (2006). Bioorg. Med. Chem. Lett. 16, 628–632.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationHu, T., Stearns, B. A., Campbell, B. T., Arruda, J. M., Chen, C., Aiyar, J., Bezverkov, R. E., Santini, A., Schaffhauser, H., Liu, W., Venkatraman, S. & Munoz, B. (2004). Bioorg. Med. Chem. Lett. 14, 2031–2034.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationSheldrick, G. M. (1996). SADABS. University of Göttingen, Germany.  Google Scholar
 First citationSheldrick, G. M. (2008). Acta Cryst. A64, 112–122.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationSpek, A. L. (2009). Acta Cryst. D65, 148–155.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationSwamy, K. M. K., Park, M. S., Han, S. J., Kim, S. K., Kim, J. H., Lee, C., Bang, H., Kim, Y., Kim, S.-J. & Yoon, J. (2005). Tetrahedron, 61, 10227–10234.  Web of Science CSD CrossRef CAS Google Scholar

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 2| February 2010| Page o259
https://doi.org/10.1107/S1600536809055081
Follow Acta Cryst. E
Sign up for e-alerts
E-alerts
Follow Acta Cryst. on Twitter
Twitter
Follow us on facebook
Facebook
Sign up for RSS feeds
RSS