2-Cyclo­hexyl-4-methyl­tetra­hydro­pyran-4-ol

Tiekink, E.R.T.; Macedo, A.; Wendler, E.P.; Dos Santos, A.A.; Zukerman-Schpector, J.

doi:10.1107/S1600536810015333

organic compounds

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ISSN: 2056-9890

Volume 66| Part 5| May 2010| Page o1223

https://doi.org/10.1107/S1600536810015333

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2-Cyclohexyl-4-methyltetrahydropyran-4-ol¹

Edward R. T. Tiekink,^a ^* Alexandra Macedo,^b Edison P. Wendler,^b Alcindo A. Dos Santos ^c and Julio Zukerman-Schpector ^b ‡

^aDepartment of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, ^bDepartment of Chemistry, Universidade Federal de São Carlos, 13565-905 São Carlos, SP, Brazil, and ^cInstituto de Química, Universidade de São Paulo, São Paulo-SP, Brazil
^*Correspondence e-mail: Edward.Tiekink@gmail.com

(Received 26 April 2010; accepted 26 April 2010; online 30 April 2010)

In the title compound, C₁₂H₂₂O₂, the 4-methyltetrahydropyran-4-ol ring adopts a conformation close to that of a chair and with the two O atoms syn; the cyclohexyl group occupies an equatorial position and adopts a chair conformation. In the crystal packing, supramolecular chains along the b axis are sustained by O—H⋯O hydrogen bonds. These are connected into undulating layers in the ab plane by C—H⋯O interactions.

Related literature

For background to the solvent-free catalysed synthesis of tetrahydropyran odorants, see: Macedo et al. (2010 ). For conformational analysis, see: Cremer & Pople (1975 )

Experimental

Crystal data

C₁₂H₂₂O₂
M_r = 198.30
Orthorhombic, P 2₁ 2₁ 2₁
a = 5.5714 (10) Å
b = 11.0182 (12) Å
c = 18.753 (3) Å
V = 1151.2 (3) Å³
Z = 4
Mo Kα radiation
μ = 0.08 mm⁻¹
T = 153 K
0.20 × 0.10 × 0.08 mm

Data collection

Rigaku AFC12/SATURN724 diffractometer
Absorption correction: multi-scan (ABSCOR; Higashi, 1995 ) T_min = 0.510, T_max = 1.000
8308 measured reflections
1404 independent reflections
1338 reflections with I > 2σ(I)
R_int = 0.040

Refinement

R[F² > 2σ(F²)] = 0.047
wR(F²) = 0.107
S = 1.18
1404 reflections
128 parameters
H-atom parameters constrained
Δρ_max = 0.17 e Å⁻³
Δρ_min = −0.18 e Å⁻³

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O2—H1o⋯O1ⁱ	0.92	1.88	2.773 (2)	164
C13—H13b⋯O2ⁱⁱ	0.98	2.40	3.337 (3)	159
C6—H6b⋯O2ⁱⁱ	0.99	2.58	3.552 (3)	168
Symmetry codes: (i) $[-x, y+{\script{1\over 2}}, -z+{\script{1\over 2}}]$ ; (ii) x+1, y, z.

Data collection: CrystalClear (Rigaku/MSC, 2005 ); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SIR97 (Altomare et al., 1999 ); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ); molecular graphics: ORTEP-3( Farrugia, 1997 ) and DIAMOND (Brandenburg, 2006 ); software used to prepare material for publication: publCIF (Westrip, 2010 ).

Supporting information

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S1600536810015333/su2176sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536810015333/su2176Isup2.hkl

checkCIF report

Comment top

The structure of the title compound, (I), was investigated as a part of a study into the solvent-free catalysed synthesis of tetrahydropyran odorants (Macedo et al., 2010). The key observation in the molecular structure is the syn relationship of the oxygen atoms. The six-membered 4-methyltetrahydropyran-4-ol ring adopts a conformation close to a chair as defined by the ring-puckering parameters of q₂ = 0.041 (2) Å, q₃ = -0.559 (2) Å, Q = 0.560 (2) Å, θ = 176.6 (2) °, and φ₂ = 159 (3) ° (Cremer & Pople, 1975). The cyclohexyl substituent occupies an equatorial position and adopts an almost perfect chair conformation. In the crystal packing, O–H···O hydrogen bonding leads to the formation of supramolecular chains along the b axis, Table 1. These are connected by C–H···O contacts into a 2-D array in the ab plane, Fig. 2 and Table 1. The layers have an undulating topology and the pendent cyclohexyl rings inter-digitate along the c axis, Fig. 3.

Related literature top

For background to solvent-free catalysed synthesis of tetrahydropyran odorants, see: Macedo et al. (2010). For conformational analysis, see: Cremer & Pople (1975)

Experimental top

The preparation and characterisation is as described in the literature (Macedo et al., 2010). The compound was dissolved in a mixture of hexane:ethyl acetate (2:1) and left to stand for five days at room temperature. The white irregular crystals were collected and washed with a small amount of hexane before drying in air.

Structure description top

For background to solvent-free catalysed synthesis of tetrahydropyran odorants, see: Macedo et al. (2010). For conformational analysis, see: Cremer & Pople (1975)

Computing details top

Data collection: CrystalClear (Rigaku/MSC, 2005); cell refinement: CrystalClear (Rigaku/MSC, 2005); data reduction: CrystalClear (Rigaku/MSC, 2005); program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3( Farrugia, 1997) and DIAMOND (Brandenburg, 2006); software used to prepare material for publication: publCIF (Westrip, 2010).

Figures top

	Fig. 1. The molecular structure of (I) showing the atom-labelling scheme and displacement ellipsoids at the 50% probability level.
	Fig. 2. A view of a supramolecular layer in (I) in the ab plane. The O–H···O hydrogen bonds and C–H···O contacts are shown as orange and blue dashed lines, respectively. Colour code: O, red; C, grey; and H, green.
	Fig. 3. Stacking of undulating layers in (I) along the c direction. The O–H···O hydrogen bonds are shown as orange dashed lines. Colour code: O, red; C, grey; and H, green.

2-Cyclohexyl-4-methyltetrahydropyran-4-ol top

Crystal data top

C₁₂H₂₂O₂	F(000) = 440
M_r = 198.30	D_x = 1.144 Mg m⁻³
Orthorhombic, P2₁2₁2₁	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 3569 reflections
a = 5.5714 (10) Å	θ = 2.9–30.1°
b = 11.0182 (12) Å	µ = 0.08 mm⁻¹
c = 18.753 (3) Å	T = 153 K
V = 1151.2 (3) Å³	Prism, colourless
Z = 4	0.20 × 0.10 × 0.08 mm

Data collection top

Rigaku AFC12K/SATURN724 diffractometer	1404 independent reflections
Radiation source: fine-focus sealed tube	1338 reflections with I > 2σ(I)
Graphite monochromator	R_int = 0.040
ω scans	θ_max = 26.5°, θ_min = 2.9°
Absorption correction: multi-scan (ABSCOR; Higashi, 1995)	h = −5→6
T_min = 0.510, T_max = 1.000	k = −13→13
8308 measured reflections	l = −23→23

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.047	Hydrogen site location: inferred from neighbouring sites
wR(F²) = 0.107	H-atom parameters constrained
S = 1.18	w = 1/[σ²(F_o²) + (0.0449P)² + 0.288P] where P = (F_o² + 2F_c²)/3
1404 reflections	(Δ/σ)_max < 0.001
128 parameters	Δρ_max = 0.17 e Å⁻³
0 restraints	Δρ_min = −0.18 e Å⁻³

Crystal data top

C₁₂H₂₂O₂	V = 1151.2 (3) Å³
M_r = 198.30	Z = 4
Orthorhombic, P2₁2₁2₁	Mo Kα radiation
a = 5.5714 (10) Å	µ = 0.08 mm⁻¹
b = 11.0182 (12) Å	T = 153 K
c = 18.753 (3) Å	0.20 × 0.10 × 0.08 mm

Data collection top

Rigaku AFC12K/SATURN724 diffractometer	1404 independent reflections
Absorption correction: multi-scan (ABSCOR; Higashi, 1995)	1338 reflections with I > 2σ(I)
T_min = 0.510, T_max = 1.000	R_int = 0.040
8308 measured reflections

Refinement top

R[F² > 2σ(F²)] = 0.047	0 restraints
wR(F²) = 0.107	H-atom parameters constrained
S = 1.18	Δρ_max = 0.17 e Å⁻³
1404 reflections	Δρ_min = −0.18 e Å⁻³
128 parameters

Special details top

Geometry. All s.u.'s (except the s.u. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell s.u.'s are taken into account individually in the estimation of s.u.'s in distances, angles and torsion angles; correlations between s.u.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell s.u.'s is used for estimating s.u.'s involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > 2σ(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. In the absence of significant anomalous scattering effects, 967 Friedel pairs were averaged in the final refinement.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
O1	0.2884 (3)	0.09963 (12)	0.27691 (8)	0.0230 (4)
O2	−0.2092 (3)	0.37416 (14)	0.28439 (9)	0.0274 (4)
H1o	−0.2118	0.4452	0.2586	0.033*
C2	0.2556 (4)	0.15401 (18)	0.34614 (11)	0.0208 (5)
H2A	0.3980	0.2060	0.3573	0.025*
C3	0.0318 (4)	0.23271 (19)	0.34544 (12)	0.0230 (5)
H3A	0.0170	0.2740	0.3921	0.028*
H3B	−0.1105	0.1799	0.3394	0.028*
C4	0.0323 (4)	0.32838 (19)	0.28640 (12)	0.0220 (5)
C5	0.0907 (4)	0.26595 (19)	0.21548 (12)	0.0233 (5)
H5A	−0.0463	0.2143	0.2011	0.028*
H5B	0.1142	0.3283	0.1781	0.028*
C6	0.3154 (5)	0.18839 (19)	0.22109 (12)	0.0241 (5)
H6A	0.3446	0.1468	0.1751	0.029*
H6B	0.4555	0.2408	0.2314	0.029*
C7	0.2457 (5)	0.04850 (19)	0.39950 (11)	0.0212 (5)
H7	0.1038	−0.0030	0.3872	0.025*
C8	0.4706 (5)	−0.0307 (2)	0.39425 (12)	0.0262 (6)
H8A	0.4827	−0.0643	0.3454	0.031*
H8B	0.6142	0.0202	0.4028	0.031*
C9	0.4676 (5)	−0.1351 (2)	0.44794 (12)	0.0313 (6)
H9A	0.3330	−0.1905	0.4367	0.038*
H9B	0.6190	−0.1817	0.4441	0.038*
C10	0.4400 (5)	−0.0879 (2)	0.52343 (12)	0.0296 (6)
H10A	0.5826	−0.0390	0.5363	0.036*
H10B	0.4299	−0.1572	0.5569	0.036*
C11	0.2151 (5)	−0.0102 (2)	0.53033 (12)	0.0307 (6)
H11A	0.2066	0.0238	0.5792	0.037*
H11B	0.0716	−0.0616	0.5229	0.037*
C12	0.2135 (5)	0.0940 (2)	0.47612 (11)	0.0281 (6)
H12A	0.3446	0.1514	0.4877	0.034*
H12B	0.0596	0.1385	0.4798	0.034*
C13	0.2059 (5)	0.43185 (19)	0.30228 (12)	0.0246 (5)
H13A	0.2006	0.4911	0.2633	0.037*
H13B	0.3691	0.3995	0.3067	0.037*
H13C	0.1595	0.4715	0.3470	0.037*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
O1	0.0312 (9)	0.0196 (7)	0.0183 (7)	0.0014 (7)	0.0004 (7)	−0.0011 (6)
O2	0.0215 (8)	0.0250 (8)	0.0358 (9)	0.0037 (7)	0.0021 (8)	0.0072 (7)
C2	0.0233 (12)	0.0215 (10)	0.0174 (10)	−0.0009 (10)	0.0015 (9)	−0.0014 (8)
C3	0.0250 (12)	0.0218 (10)	0.0222 (10)	0.0013 (10)	0.0021 (10)	0.0005 (9)
C4	0.0217 (12)	0.0204 (10)	0.0238 (10)	0.0006 (9)	0.0013 (10)	−0.0003 (9)
C5	0.0275 (12)	0.0213 (10)	0.0211 (11)	−0.0026 (10)	−0.0024 (10)	0.0014 (9)
C6	0.0290 (13)	0.0225 (10)	0.0208 (10)	−0.0008 (10)	0.0033 (11)	0.0019 (9)
C7	0.0230 (13)	0.0209 (10)	0.0198 (10)	0.0001 (10)	0.0004 (10)	0.0012 (8)
C8	0.0273 (14)	0.0278 (12)	0.0237 (11)	0.0054 (11)	0.0027 (11)	0.0017 (9)
C9	0.0364 (15)	0.0278 (12)	0.0297 (12)	0.0092 (12)	0.0004 (12)	0.0044 (10)
C10	0.0347 (15)	0.0285 (12)	0.0257 (11)	0.0028 (12)	−0.0031 (11)	0.0076 (10)
C11	0.0387 (15)	0.0330 (12)	0.0205 (10)	0.0016 (13)	0.0024 (12)	0.0030 (10)
C12	0.0371 (15)	0.0262 (11)	0.0209 (10)	0.0052 (12)	0.0037 (11)	0.0016 (9)
C13	0.0247 (12)	0.0210 (10)	0.0281 (11)	0.0006 (10)	0.0032 (10)	−0.0010 (9)

Geometric parameters (Å, º) top

O1—C2	1.441 (2)	C7—H7	1.0000
O1—C6	1.440 (2)	C8—C9	1.529 (3)
O2—C4	1.438 (3)	C8—H8A	0.9900
O2—H1O	0.9200	C8—H8B	0.9900
C2—C3	1.519 (3)	C9—C10	1.516 (3)
C2—C7	1.535 (3)	C9—H9A	0.9900
C2—H2A	1.0000	C9—H9B	0.9900
C3—C4	1.529 (3)	C10—C11	1.524 (4)
C3—H3A	0.9900	C10—H10A	0.9900
C3—H3B	0.9900	C10—H10B	0.9900
C4—C13	1.524 (3)	C11—C12	1.533 (3)
C4—C5	1.532 (3)	C11—H11A	0.9900
C5—C6	1.519 (3)	C11—H11B	0.9900
C5—H5A	0.9900	C12—H12A	0.9900
C5—H5B	0.9900	C12—H12B	0.9900
C6—H6A	0.9900	C13—H13A	0.9800
C6—H6B	0.9900	C13—H13B	0.9800
C7—C8	1.530 (3)	C13—H13C	0.9800
C7—C12	1.532 (3)

C2—O1—C6	112.68 (15)	C2—C7—H7	108.0
C4—O2—H1O	109.1	C9—C8—C7	112.20 (19)
O1—C2—C3	109.48 (17)	C9—C8—H8A	109.2
O1—C2—C7	106.08 (15)	C7—C8—H8A	109.2
C3—C2—C7	114.10 (18)	C9—C8—H8B	109.2
O1—C2—H2A	109.0	C7—C8—H8B	109.2
C3—C2—H2A	109.0	H8A—C8—H8B	107.9
C7—C2—H2A	109.0	C10—C9—C8	110.99 (19)
C2—C3—C4	113.48 (18)	C10—C9—H9A	109.4
C2—C3—H3A	108.9	C8—C9—H9A	109.4
C4—C3—H3A	108.9	C10—C9—H9B	109.4
C2—C3—H3B	108.9	C8—C9—H9B	109.4
C4—C3—H3B	108.9	H9A—C9—H9B	108.0
H3A—C3—H3B	107.7	C9—C10—C11	110.8 (2)
O2—C4—C13	109.66 (17)	C9—C10—H10A	109.5
O2—C4—C3	105.02 (18)	C11—C10—H10A	109.5
C13—C4—C3	112.05 (18)	C9—C10—H10B	109.5
O2—C4—C5	109.49 (18)	C11—C10—H10B	109.5
C13—C4—C5	111.76 (19)	H10A—C10—H10B	108.1
C3—C4—C5	108.63 (17)	C10—C11—C12	111.7 (2)
C6—C5—C4	111.56 (18)	C10—C11—H11A	109.3
C6—C5—H5A	109.3	C12—C11—H11A	109.3
C4—C5—H5A	109.3	C10—C11—H11B	109.3
C6—C5—H5B	109.3	C12—C11—H11B	109.3
C4—C5—H5B	109.3	H11A—C11—H11B	107.9
H5A—C5—H5B	108.0	C11—C12—C7	112.08 (18)
O1—C6—C5	110.25 (18)	C11—C12—H12A	109.2
O1—C6—H6A	109.6	C7—C12—H12A	109.2
C5—C6—H6A	109.6	C11—C12—H12B	109.2
O1—C6—H6B	109.6	C7—C12—H12B	109.2
C5—C6—H6B	109.6	H12A—C12—H12B	107.9
H6A—C6—H6B	108.1	C4—C13—H13A	109.5
C8—C7—C12	110.03 (19)	C4—C13—H13B	109.5
C8—C7—C2	111.11 (18)	H13A—C13—H13B	109.5
C12—C7—C2	111.57 (17)	C4—C13—H13C	109.5
C8—C7—H7	108.0	H13A—C13—H13C	109.5
C12—C7—H7	108.0	H13B—C13—H13C	109.5

C6—O1—C2—C3	59.9 (2)	O1—C2—C7—C8	56.2 (2)
C6—O1—C2—C7	−176.59 (18)	C3—C2—C7—C8	176.83 (18)
O1—C2—C3—C4	−54.8 (2)	O1—C2—C7—C12	179.4 (2)
C7—C2—C3—C4	−173.46 (18)	C3—C2—C7—C12	−60.0 (3)
C2—C3—C4—O2	167.77 (17)	C12—C7—C8—C9	54.8 (3)
C2—C3—C4—C13	−73.3 (2)	C2—C7—C8—C9	178.84 (19)
C2—C3—C4—C5	50.7 (2)	C7—C8—C9—C10	−56.7 (3)
O2—C4—C5—C6	−165.23 (17)	C8—C9—C10—C11	56.2 (3)
C13—C4—C5—C6	73.1 (2)	C9—C10—C11—C12	−55.4 (3)
C3—C4—C5—C6	−51.1 (2)	C10—C11—C12—C7	54.6 (3)
C2—O1—C6—C5	−61.8 (2)	C8—C7—C12—C11	−53.5 (3)
C4—C5—C6—O1	57.0 (2)	C2—C7—C12—C11	−177.3 (2)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
O2—H1o···O1ⁱ	0.92	1.88	2.773 (2)	164
C13—H13b···O2ⁱⁱ	0.98	2.40	3.337 (3)	159
C6—H6b···O2ⁱⁱ	0.99	2.58	3.552 (3)	168

Symmetry codes: (i) −x, y+1/2, −z+1/2; (ii) x+1, y, z.

Experimental details

Crystal data
Chemical formula	C₁₂H₂₂O₂
M_r	198.30
Crystal system, space group	Orthorhombic, P2₁2₁2₁
Temperature (K)	153
a, b, c (Å)	5.5714 (10), 11.0182 (12), 18.753 (3)
V (Å³)	1151.2 (3)
Z	4
Radiation type	Mo Kα
µ (mm⁻¹)	0.08
Crystal size (mm)	0.20 × 0.10 × 0.08

Data collection
Diffractometer	Rigaku AFC12K/SATURN724
Absorption correction	Multi-scan (ABSCOR; Higashi, 1995)
T_min, T_max	0.510, 1.000
No. of measured, independent and observed [I > 2σ(I)] reflections	8308, 1404, 1338
R_int	0.040
(sin θ/λ)_max (Å⁻¹)	0.628

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.047, 0.107, 1.18
No. of reflections	1404
No. of parameters	128
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.17, −0.18

Computer programs: CrystalClear (Rigaku/MSC, 2005), SIR97 (Altomare et al., 1999), SHELXL97 (Sheldrick, 2008), ORTEP-3( Farrugia, 1997) and DIAMOND (Brandenburg, 2006), publCIF (Westrip, 2010).

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
O2—H1o···O1ⁱ	0.92	1.88	2.773 (2)	164
C13—H13b···O2ⁱⁱ	0.98	2.40	3.337 (3)	159
C6—H6b···O2ⁱⁱ	0.99	2.58	3.552 (3)	168

Symmetry codes: (i) −x, y+1/2, −z+1/2; (ii) x+1, y, z.

Footnotes

¹Data reported in this paper were previously deposited with the CCDC (746915).

‡Additional correspondence author, email: julio@power.ufscar.br.

Acknowledgements

We thank FAPESP, CNPq (306532/2009-3 to JZS) and CAPES for financial support.

References

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