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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 6| June 2010| Page o1366
https://doi.org/10.1107/S1600536810017502

Alternariol

David Siegel,a* Sergey Troyanov,b Johannes Noack,b Franziska Emmerlinga and Irene Nehlsa

aBundesanstalt fur Materialforschung und -prüfung, Abteilung Analytische Chemie; Referenzmaterialien, Richard-Willstätter-Strasse 11, D-12489 Berlin-Adlershof, Germany, and bHumboldt-Universität zu Berlin, Department of Chemistry, Brook-Taylor-Strasse 2, 12489 Berlin, Germany
*Correspondence e-mail: david.siegel@chemie.hu-berlin.de

(Received 10 May 2010; accepted 12 May 2010; online 15 May 2010)

In the title compound (systematic name: 3,7,9-trihydr­oxy-1-methyl-6H-benzo[c]chromen-6-one), C14H10O5, the methyl group is shifted out of the molecular plane due to a steric collision, thus causing a slight twist of the benzene rings. The mol­ecular structure is stabilized by an intra­molecular O—H⋯O hydrogen bond, generating an S(6) ring. In the crystal, mol­ecules are connected by inter­molecular O—H⋯O hydrogen bonds into a three-dimensional network.

Related literature

Alternariol is a mycotoxin (toxic secondary fungal metabolite) produced by ubiquitous Alternaria moulds. For information on occurence and toxicity, see: Weidenbörner (2001[Weidenbörner, M. (2001). Encyclopedia of Food Mycotoxins, 1st ed. Berlin: Springer.]); Brugger et al. (2006[Brugger, E. M., Wagner, J., Schumacher, D. M., Koch, K., Podlech, J., Metzler, M. & Lehmann, L. (2006). Toxicol. Lett. 164, 221-230.]); Wollenhaupt et al. (2008[Wollenhaupt, K., Schneider, F. & Tiemann, U. (2008). Toxicol. Lett. 182, 57-62.]); Fehr et al. (2009[Fehr, M., Pahlke, G., Fritz, J., Christensen, M. O., Boege, F., Altemoller, M., Podlech, J. & Marko, D. (2009). Mol. Nutr. Food Res. 53, 441-451.]). For crystallization, alternariol was obtained by total synthesis according to Koch et al. (2005[Koch, K., Podlech, J., Pfeiffer, E. & Metzler, M. (2005). J. Org. Chem. 70, 3275-3276.]). For a comparable structure, (2-chloro-7-hydr­oxy-8-methyl-6H-benzo[c]chromen-6-one), see: Appel et al. (2006[Appel, B., Saleh, N. N. R. & Langer, P. (2006). Chem. Eur. J. 12, 1221-1236.]).

[Scheme 1]

Experimental

Crystal data

  • C14H10O5

  • Mr = 258.22

  • Orthorhombic, P c a 21

  • a = 18.969 (3) Å

  • b = 3.7244 (6) Å

  • c = 15.235 (3) Å

  • V = 1076.3 (3) Å3

  • Z = 4

  • Mo Kα radiation

  • μ = 0.12 mm−1

  • T = 150 K

  • 0.40 × 0.10 × 0.02 mm
Data collection

  • Stoe IPDS diffractometer

  • 6072 measured reflections

  • 1338 independent reflections

  • 1053 reflections with I > 2σ(I)

  • Rint = 0.067
Refinement

  • R[F2 > 2σ(F2)] = 0.035

  • wR(F2) = 0.069

  • S = 0.99

  • 1338 reflections

  • 191 parameters

  • 1 restraint

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.16 e Å−3

  • Δρmin = −0.23 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
O3—H3⋯O2 0.86 (3) 1.82 (3) 2.605 (3) 152 (3)
O4—H4⋯O2i 0.91 (3) 1.81 (3) 2.685 (3) 162 (3)
O5—H5⋯O4ii 0.84 1.97 2.809 (2) 175
Symmetry codes: (i) [-x+1, -y, z-{\script{1\over 2}}]; (ii) [-x+{\script{3\over 2}}, y+1, z+{\script{1\over 2}}].

Data collection: X-AREA (Stoe & Cie, 2006[Stoe & Cie (2006). X-AREA. Stoe & Cie, Darmstadt, Germany.]); cell refinement: X-AREA; data reduction: X-AREA; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: DIAMOND (Brandenburg, 2010[Brandenburg, K. (2010). DIAMOND. Crystal Impact GbR, Bonn, Germany.]) and ORTEPIII (Burnett & Johnson, 1996[Burnett, M. N. & Johnson, C. K. (1996). ORTEPIII. Report ORNL-6895. Oak Ridge National Laboratory, Tennessee, USA.]); software used to prepare material for publication: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]).

Supporting information

Crystal structure: contains datablocks I, global. DOI: https://doi.org/10.1107/S1600536810017502/bt5266sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536810017502/bt5266Isup2.hkl

checkCIF report


Comment top

Alternariol is a cytotoxic, fetotoxic, teratogenic (Weidenbörner, 2001), mutagenic (Brugger et al., 2006, Wollenhaupt et al., 2008) and genotoxic (Fehr et al., 2009) mycotoxin produced by ubiquitous Alternaria fungi. It naturally occurs on fruits, vegetables and cereals like apples, tomatoes or wheat (Weidenbörner, 2001) and has also been obtained by total synthesis (Koch et al., 2005). The molecular structure of the title compound and the atom-labeling scheme are shown in Fig. 1. It is noteworthy that the benzene rings are not fully coplanar. This phenomenon is not observed for the benzo[c]chromen-6-one analogue 2-chloro-7-hydroxy-8-methyl-6H-benzo[c]chromen-6-one (Appel et al., 2006). Hence, the lacking planarity of the alternariol molecule may be attributed to a steric effect caused by the proximity of the H6A hydrogen to the C14 methyl group, which is not present in the planar analogue. This explanation is corroborated by the fact that the C8—C13—C14 angle is increased to 124.93 (17)°. The absolute configuration cannot be derived confidently since the molecule is a weak anomalous scatterer, which is documented by a large s.u. value for the Flack X parameter. Besides the intramolecular hydrogen bonds between O3—H3 and O2 (see dashed blue bonds in fig. 2), each molecule is connected to four adjacent molecules via intermolecular hydrogen bonds (see dashed green bonds in fig. 2). As a result undulated layers in the the ac plane are formed.

Related literature top

For information on alternariol, see: Weidenbörner (2001); Brugger et al. (2006); Wollenhaupt et al. (2008); Fehr et al. (2009). For the total synthesis of alternariol, see: Koch et al. (2005). For a comparable structure, (2-chloro-7-hydroxy-8-methyl-6H-benzo[c]chromen-6-one), see: Appel et al. (2006).

Experimental top

Alternariol was supplied by the workgroup of Prof. R. Faust (University of Kassel, Germany) by total synthesis according to a literature procedure (Koch et al., 2005). Alternariol crystals were grown by sublimation in argon atmosphere. To do so, 100 mg of crude alternariol were heated to 380 °C for 2.5 h under a slow argon flow (atmospheric pressure). After cooling to room temperature, colourless needles could be collected from the water cooled compartment of the reaction vessel.

Refinement top

In the absence of anomalous scatterers, the absolute structure cannot be determined therefore Friedel pairs were merged prior to refinement. The hydrogen atoms were located in difference maps and refined with Uiso(H) set to 1.2 Ueq of the parent atom (1.5 for methyl groups).

Structure description top

Alternariol is a cytotoxic, fetotoxic, teratogenic (Weidenbörner, 2001), mutagenic (Brugger et al., 2006, Wollenhaupt et al., 2008) and genotoxic (Fehr et al., 2009) mycotoxin produced by ubiquitous Alternaria fungi. It naturally occurs on fruits, vegetables and cereals like apples, tomatoes or wheat (Weidenbörner, 2001) and has also been obtained by total synthesis (Koch et al., 2005). The molecular structure of the title compound and the atom-labeling scheme are shown in Fig. 1. It is noteworthy that the benzene rings are not fully coplanar. This phenomenon is not observed for the benzo[c]chromen-6-one analogue 2-chloro-7-hydroxy-8-methyl-6H-benzo[c]chromen-6-one (Appel et al., 2006). Hence, the lacking planarity of the alternariol molecule may be attributed to a steric effect caused by the proximity of the H6A hydrogen to the C14 methyl group, which is not present in the planar analogue. This explanation is corroborated by the fact that the C8—C13—C14 angle is increased to 124.93 (17)°. The absolute configuration cannot be derived confidently since the molecule is a weak anomalous scatterer, which is documented by a large s.u. value for the Flack X parameter. Besides the intramolecular hydrogen bonds between O3—H3 and O2 (see dashed blue bonds in fig. 2), each molecule is connected to four adjacent molecules via intermolecular hydrogen bonds (see dashed green bonds in fig. 2). As a result undulated layers in the the ac plane are formed.

For information on alternariol, see: Weidenbörner (2001); Brugger et al. (2006); Wollenhaupt et al. (2008); Fehr et al. (2009). For the total synthesis of alternariol, see: Koch et al. (2005). For a comparable structure, (2-chloro-7-hydroxy-8-methyl-6H-benzo[c]chromen-6-one), see: Appel et al. (2006).

Computing details top

Data collection: X-AREA (Stoe & Cie, 2006); cell refinement: X-AREA (Stoe & Cie, 2006); data reduction: X-AREA (Stoe & Cie, 2006); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: DIAMOND (Brandenburg, 2010) and ORTEPIII (Burnett & Johnson, 1996); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. : ORTEP representation of the title compound with atomic labeling shown with 30% probability displacement ellipsoids.
[Figure 2] Fig. 2. : View of the unit cell of the title compound along [010], showing the hydrogen-bonded layers.
3,7,9-trihydroxy-1-methyl-6H-benzo[c]chromen-6-one top
Crystal data top
C14H10O5F(000) = 536
Mr = 258.22Dx = 1.594 Mg m−3
Orthorhombic, Pca21Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2c -2acCell parameters from 1894 reflections
a = 18.969 (3) Åθ = 5–26°
b = 3.7244 (6) ŵ = 0.12 mm−1
c = 15.235 (3) ÅT = 150 K
V = 1076.3 (3) Å3Needle, colourless
Z = 40.40 × 0.10 × 0.02 mm
Data collection top
Stoe IPDS
diffractometer		1053 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.067
Graphite monochromatorθmax = 28.1°, θmin = 2.5°
rotation method scansh = −24→22
6072 measured reflectionsk = −4→4
1338 independent reflectionsl = −20→20
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.035Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.069H atoms treated by a mixture of independent and constrained refinement
S = 0.99 w = 1/[σ2(Fo2) + (0.0314P)2]
where P = (Fo2 + 2Fc2)/3
1338 reflections(Δ/σ)max < 0.001
191 parametersΔρmax = 0.16 e Å−3
1 restraintΔρmin = −0.23 e Å−3
Crystal data top
C14H10O5V = 1076.3 (3) Å3
Mr = 258.22Z = 4
Orthorhombic, Pca21Mo Kα radiation
a = 18.969 (3) ŵ = 0.12 mm−1
b = 3.7244 (6) ÅT = 150 K
c = 15.235 (3) Å0.40 × 0.10 × 0.02 mm
Data collection top
Stoe IPDS
diffractometer		1053 reflections with I > 2σ(I)
6072 measured reflectionsRint = 0.067
1338 independent reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0351 restraint
wR(F2) = 0.069H atoms treated by a mixture of independent and constrained refinement
S = 0.99Δρmax = 0.16 e Å−3
1338 reflectionsΔρmin = −0.23 e Å−3
191 parameters
Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.54295 (9)0.3728 (6)0.78417 (11)0.0213 (4)
O20.44464 (9)0.1215 (6)0.74006 (11)0.0272 (5)
O30.42666 (9)−0.0612 (6)0.57652 (13)0.0277 (5)
H30.4192 (17)−0.038 (10)0.632 (2)0.033*
O40.61983 (10)0.1209 (7)0.38531 (11)0.0275 (5)
H40.5946 (18)0.002 (10)0.344 (2)0.033*
O50.74389 (10)0.8553 (6)0.91670 (10)0.0260 (5)
H50.78430.93070.90380.031*
C10.50516 (13)0.2203 (8)0.71956 (16)0.0193 (6)
C20.53589 (13)0.1856 (8)0.63425 (15)0.0167 (6)
C30.49365 (13)0.0493 (8)0.56447 (16)0.0192 (6)
C40.52045 (14)0.0246 (8)0.48049 (17)0.0194 (6)
H4A0.4917 (15)−0.072 (8)0.4295 (19)0.023*
C50.58935 (13)0.1357 (9)0.46651 (15)0.0183 (6)
C60.63205 (15)0.2688 (8)0.53304 (15)0.0178 (6)
H6A0.6788 (15)0.341 (8)0.5183 (18)0.021*
C70.60688 (12)0.2911 (7)0.61830 (15)0.0135 (5)
C80.64850 (13)0.4228 (7)0.69286 (14)0.0141 (5)
C90.61339 (12)0.4710 (8)0.77287 (16)0.0166 (6)
C100.64335 (14)0.6136 (8)0.84775 (16)0.0194 (6)
H100.6189 (14)0.644 (8)0.9006 (18)0.023*
C110.71326 (13)0.7093 (8)0.84418 (16)0.0186 (6)
C120.75199 (13)0.6479 (8)0.76803 (16)0.0159 (5)
H120.7968 (16)0.696 (8)0.7685 (17)0.019*
C130.72187 (13)0.5072 (7)0.69300 (15)0.0146 (5)
C140.77182 (13)0.4380 (8)0.61791 (16)0.0198 (6)
H14A0.82050.46830.63820.030*
H14B0.76220.60830.57040.030*
H14C0.76520.19230.59640.030*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0154 (8)0.0343 (13)0.0141 (8)−0.0028 (8)0.0031 (6)−0.0013 (9)
O20.0164 (9)0.0475 (14)0.0177 (8)−0.0068 (9)0.0028 (7)0.0060 (9)
O30.0125 (9)0.0439 (14)0.0268 (10)−0.0096 (9)0.0011 (8)−0.0021 (11)
O40.0164 (9)0.0518 (15)0.0143 (9)−0.0034 (10)−0.0002 (7)−0.0092 (9)
O50.0244 (10)0.0405 (13)0.0131 (8)−0.0053 (9)−0.0034 (7)−0.0063 (9)
C10.0152 (13)0.0243 (18)0.0183 (13)−0.0006 (11)−0.0013 (9)0.0027 (11)
C20.0139 (12)0.0187 (16)0.0176 (12)0.0002 (10)0.0010 (9)0.0038 (11)
C30.0113 (12)0.0239 (17)0.0222 (13)−0.0027 (11)−0.0021 (10)0.0012 (12)
C40.0166 (13)0.0218 (17)0.0200 (12)0.0027 (11)−0.0052 (10)−0.0022 (11)
C50.0149 (13)0.0277 (17)0.0123 (11)0.0025 (12)0.0021 (9)−0.0019 (12)
C60.0134 (12)0.0226 (17)0.0175 (12)0.0001 (10)0.0012 (9)−0.0003 (11)
C70.0124 (11)0.0153 (15)0.0127 (11)0.0024 (9)0.0007 (9)0.0026 (11)
C80.0170 (12)0.0150 (14)0.0102 (10)0.0036 (10)−0.0006 (9)−0.0001 (10)
C90.0129 (11)0.0216 (17)0.0153 (10)0.0008 (10)−0.0006 (10)0.0035 (11)
C100.0207 (14)0.0257 (17)0.0117 (11)0.0037 (11)0.0030 (9)0.0001 (11)
C110.0205 (13)0.0227 (17)0.0125 (11)0.0014 (11)−0.0061 (10)−0.0013 (11)
C120.0124 (11)0.0191 (15)0.0163 (11)0.0014 (10)−0.0020 (9)0.0014 (11)
C130.0166 (12)0.0139 (15)0.0133 (10)0.0023 (10)0.0015 (9)0.0030 (10)
C140.0130 (12)0.0279 (17)0.0184 (11)−0.0009 (10)0.0004 (9)−0.0038 (12)
Geometric parameters (Å, º) top
O1—C11.343 (3)C6—C71.386 (3)
O1—C91.396 (3)C6—H6A0.95 (3)
O2—C11.245 (3)C7—C81.468 (3)
O3—C31.348 (3)C8—C91.401 (3)
O3—H30.86 (3)C8—C131.427 (4)
O4—C51.367 (3)C9—C101.381 (4)
O4—H40.91 (4)C10—C111.374 (4)
O5—C111.362 (3)C10—H100.94 (3)
O5—H50.8400C11—C121.392 (4)
C1—C21.430 (3)C12—C131.381 (4)
C2—C71.424 (3)C12—H120.87 (3)
C2—C31.425 (4)C13—C141.508 (3)
C3—C41.380 (3)C14—H14A0.9800
C4—C51.387 (4)C14—H14B0.9800
C4—H4A1.01 (3)C14—H14C0.9800
C5—C61.389 (4)
C1—O1—C9122.07 (19)C9—C8—C13115.7 (2)
C3—O3—H3105 (2)C9—C8—C7117.4 (2)
C5—O4—H4115 (2)C13—C8—C7126.8 (2)
C11—O5—H5109.5C10—C9—O1113.1 (2)
O2—C1—O1115.6 (2)C10—C9—C8124.9 (2)
O2—C1—C2125.2 (2)O1—C9—C8121.9 (2)
O1—C1—C2119.1 (2)C11—C10—C9117.7 (2)
C7—C2—C3120.2 (2)C11—C10—H10118.7 (17)
C7—C2—C1121.0 (2)C9—C10—H10123.6 (17)
C3—C2—C1118.8 (2)O5—C11—C10118.9 (2)
O3—C3—C4116.9 (2)O5—C11—C12121.1 (2)
O3—C3—C2122.5 (2)C10—C11—C12120.0 (2)
C4—C3—C2120.6 (2)C13—C12—C11122.2 (2)
C3—C4—C5118.0 (2)C13—C12—H12119.3 (18)
C3—C4—H4A122.4 (16)C11—C12—H12118.4 (18)
C5—C4—H4A119.6 (16)C12—C13—C8119.2 (2)
O4—C5—C4121.7 (2)C12—C13—C14115.6 (2)
O4—C5—C6115.4 (2)C8—C13—C14125.1 (2)
C4—C5—C6122.9 (2)C13—C14—H14A109.5
C7—C6—C5120.3 (2)C13—C14—H14B109.5
C7—C6—H6A121.6 (17)H14A—C14—H14B109.5
C5—C6—H6A118.1 (17)C13—C14—H14C109.5
C6—C7—C2118.0 (2)H14A—C14—H14C109.5
C6—C7—C8124.1 (2)H14B—C14—H14C109.5
C2—C7—C8118.0 (2)
C9—O1—C1—O2174.9 (2)C6—C7—C8—C9172.4 (3)
C9—O1—C1—C2−5.6 (4)C2—C7—C8—C9−6.5 (4)
O2—C1—C2—C7−176.9 (3)C6—C7—C8—C13−7.9 (4)
O1—C1—C2—C73.6 (4)C2—C7—C8—C13173.3 (3)
O2—C1—C2—C34.3 (4)C1—O1—C9—C10−178.2 (3)
O1—C1—C2—C3−175.2 (3)C1—O1—C9—C81.3 (4)
C7—C2—C3—O3178.6 (3)C13—C8—C9—C104.5 (4)
C1—C2—C3—O3−2.6 (4)C7—C8—C9—C10−175.7 (3)
C7—C2—C3—C4−1.3 (4)C13—C8—C9—O1−174.9 (2)
C1—C2—C3—C4177.5 (3)C7—C8—C9—O14.8 (4)
O3—C3—C4—C5−179.8 (3)O1—C9—C10—C11178.2 (3)
C2—C3—C4—C50.1 (4)C8—C9—C10—C11−1.3 (4)
C3—C4—C5—O4−179.9 (3)C9—C10—C11—O5179.1 (2)
C3—C4—C5—C60.1 (5)C9—C10—C11—C12−2.6 (4)
O4—C5—C6—C7−179.1 (3)O5—C11—C12—C13−178.6 (3)
C4—C5—C6—C70.9 (5)C10—C11—C12—C133.1 (4)
C5—C6—C7—C2−2.1 (4)C11—C12—C13—C80.3 (4)
C5—C6—C7—C8179.1 (3)C11—C12—C13—C14−176.7 (3)
C3—C2—C7—C62.3 (4)C9—C8—C13—C12−3.9 (4)
C1—C2—C7—C6−176.5 (3)C7—C8—C13—C12176.4 (3)
C3—C2—C7—C8−178.8 (3)C9—C8—C13—C14172.9 (3)
C1—C2—C7—C82.5 (4)C7—C8—C13—C14−6.8 (4)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
O3—H3···O20.86 (3)1.82 (3)2.605 (3)152 (3)
O4—H4···O2i0.91 (3)1.81 (3)2.685 (3)162 (3)
O5—H5···O4ii0.841.972.809 (2)175
Symmetry codes: (i) −x+1, −y, z−1/2; (ii) −x+3/2, y+1, z+1/2.

Experimental details

Crystal data
Chemical formulaC14H10O5
Mr258.22
Crystal system, space groupOrthorhombic, Pca21
Temperature (K)150
a, b, c (Å)18.969 (3), 3.7244 (6), 15.235 (3)
V (Å3)1076.3 (3)
Z4
Radiation typeMo Kα
µ (mm−1)0.12
Crystal size (mm)0.40 × 0.10 × 0.02
Data collection
DiffractometerStoe IPDS
Absorption correction–
No. of measured, independent and
observed [I > 2σ(I)] reflections		6072, 1338, 1053
Rint0.067
(sin θ/λ)max (Å−1)0.662
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.035, 0.069, 0.99
No. of reflections1338
No. of parameters191
No. of restraints1
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å−3)0.16, −0.23

Computer programs: X-AREA (Stoe & Cie, 2006), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), DIAMOND (Brandenburg, 2010) and ORTEPIII (Burnett & Johnson, 1996), SHELXTL (Sheldrick, 2008).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
O3—H3···O20.86 (3)1.82 (3)2.605 (3)152 (3)
O4—H4···O2i0.91 (3)1.81 (3)2.685 (3)162 (3)
O5—H5···O4ii0.841.972.809 (2)175
Symmetry codes: (i) −x+1, −y, z−1/2; (ii) −x+3/2, y+1, z+1/2.
 

References

First citationAppel, B., Saleh, N. N. R. & Langer, P. (2006). Chem. Eur. J. 12, 1221–1236.  Web of Science CSD CrossRef PubMed CAS Google Scholar
 First citationBrandenburg, K. (2010). DIAMOND. Crystal Impact GbR, Bonn, Germany.  Google Scholar
 First citationBrugger, E. M., Wagner, J., Schumacher, D. M., Koch, K., Podlech, J., Metzler, M. & Lehmann, L. (2006). Toxicol. Lett. 164, 221–230.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationBurnett, M. N. & Johnson, C. K. (1996). ORTEPIII. Report ORNL-6895. Oak Ridge National Laboratory, Tennessee, USA.  Google Scholar
 First citationFehr, M., Pahlke, G., Fritz, J., Christensen, M. O., Boege, F., Altemoller, M., Podlech, J. & Marko, D. (2009). Mol. Nutr. Food Res. 53, 441–451.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationKoch, K., Podlech, J., Pfeiffer, E. & Metzler, M. (2005). J. Org. Chem. 70, 3275–3276.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationSheldrick, G. M. (2008). Acta Cryst. A64, 112–122.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationStoe & Cie (2006). X-AREA. Stoe & Cie, Darmstadt, Germany.  Google Scholar
 First citationWeidenbörner, M. (2001). Encyclopedia of Food Mycotoxins, 1st ed. Berlin: Springer.  Google Scholar
 First citationWollenhaupt, K., Schneider, F. & Tiemann, U. (2008). Toxicol. Lett. 182, 57–62.  Web of Science CrossRef PubMed CAS Google Scholar

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ISSN: 2056-9890
Volume 66| Part 6| June 2010| Page o1366
https://doi.org/10.1107/S1600536810017502
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