Issue contents
Download PDF of article
Download CIF
3D view
Navigation
Highlighting
Dictionary of Crystallography reference
IUPAC Gold Book reference
more ...
Download citation
FormatBIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Plain Text
share
Previous article
Next article
Previous article
Issue contents
Download PDF of article
Download CIF
3D view
Navigation
Highlighting
Dictionary of Crystallography reference
IUPAC Gold Book reference
more ...
Download citation
FormatBIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Plain Text
share
Next article

organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 10| October 2010| Page o2642
doi:10.1107/S1600536810037712

Ethyl 7-(2-chloro­phen­yl)-5-tri­fluoro­meth­yl-4,7-di­hydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carboxyl­ate

Jie Mou,a Chen-Xia Yub,c and Chang-Sheng Yaob,c*

aSchool of Pharmacy, Xuzhou Medical College, Xuzhou 221004, People's Republic of China, bSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, People's Republic of China, and cKey Laboratory of Biotechnology for Medicinal Plants, Xuzhou Normal University, Xuzhou 221116, People's Republic of China
*Correspondence e-mail: mou.jiexuzhou@gmail.com

(Received 19 September 2010; accepted 21 September 2010; online 25 September 2010)

In the title compound, C15H12ClF3N4O2, the dihydro­pyrimidine ring exhibits an envelope conformation. The dihedral angle between the mean planes of the dihydro­pyrimidine and phenyl rings is 83.94 (6)°. The OCH2CH3 group is disordered over two sites with occupancies of 0.155 (3) and 0.845 (3). The crystal packing is stabilized by inter­molecular N—H⋯N hydrogen bonds.

Related literature

For the anti­cancer activity, inhibition of the MDM2-p53 protein–protein inter­action and the anti­tuberculosis and dehydrogenase inhibitory activity of [1,2,4]triazolo [1,5-a]pyrimidine derivatives, see: Zhang et al. (2007[Zhang, N., Ayral-Kaloustian, S., Nguyen, T., Afragola, J., Hernandez, R., Lucas, J., Gibbons, J. & Beyer, C. (2007). J. Med. Chem. 50, 319-327.]); Allen et al. (2009[Allen, J. G., Bourbeau, M. P., Wohlhieter, G. E., Bartberger, M. D., Michelsen, K., Hungate, R., Gadwood, R. C., Gaston, R. D., Evans, B., Mann, L. W., Matison, M. E., Schneider, S., Huang, X., Yu, D. Y., Andrews, P. S., Reichelt, A., Long, A. M., Yakowec, P., Yang, E. Y., Lee, T. A. & Oliner, J. D. (2009). J. Med. Chem. 52, 7044-7053.]); Pereyaslavskaya et al. (2008[Pereyaslavskaya, E. S., Potemkin, V. A., Bartashevich, E. V., Grishina, M. A., Rusinov, G. L., Fedorova, O. V., Zhidovinova, M. S. & Ovchinnikova, I. G. (2008). Pharm. Chem. J. 42, 622-625.]); Gujjar et al. (2009[Gujjar, R., Marwaha, A., El Mazouni, F., White, J., White, K. L., Creason, S., Shackleford, D. M., Baldwin, J., Charman, W. N., Buckner, F. S., Charman, S., Rathod, P. K. & Phillips, M. A. (2009). J. Med. Chem. 52, 1864-1872.]). For the bioactivity of trifluoro­methyl­ated mol­ecules, see: Kirk, (2006[Kirk, K. L. (2006). J. Fluorine Chem. 127,1013-1029.]). For the preparation of trifluoro­methyl­ated [1,2,4]triazolo[1,5-a]pyrimidine derivatives, see Pryadeina et al. (2004[Pryadeina, M. V., Burgart, Ya. V., Saloutin, V. I., Kodess, M. I., Ulomskii, E. N. & Rusinov, V. L. (2004). Russ. J. Org. Chem. 40, 902-907.]). For puckering parameters, see: Cremer & Pople (1975[Cremer, D. & Pople, J. A. (1975). J. Am. Chem. Soc. 97, 1354-1358.]).

[Scheme 1]

Experimental

Crystal data

  • C15H12ClF3N4O2

  • Mr = 372.74

  • Monoclinic, P 21 /n

  • a = 9.8927 (12) Å

  • b = 6.8055 (6) Å

  • c = 24.403 (3) Å

  • β = 99.237 (9)°

  • V = 1621.6 (3) Å3

  • Z = 4

  • Mo Kα radiation

  • μ = 0.29 mm−1

  • T = 113 K

  • 0.26 × 0.22 × 0.20 mm
Data collection

  • Rigaku Saturn diffractometer

  • Absorption correction: multi-scan (CrystalClear;Rigaku/MSC, 2002[Rigaku/MSC (2002). CrystalClear. Rigaku/MSC Inc., The Woodlands, Texas, USA.]) Tmin = 0.930, Tmax = 0.945

  • 14364 measured reflections

  • 3835 independent reflections

  • 3058 reflections with I > 2σ(I)

  • Rint = 0.043
Refinement

  • R[F2 > 2σ(F2)] = 0.047

  • wR(F2) = 0.121

  • S = 1.08

  • 3835 reflections

  • 242 parameters

  • 6 restraints

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.27 e Å−3

  • Δρmin = −0.40 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
N1—H1⋯N4i 0.90 (2) 1.96 (2) 2.843 (2) 166.3 (19)
Symmetry code: (i) -x, -y+1, -z.

Data collection: CrystalClear (Rigaku/MSC, 2002[Rigaku/MSC (2002). CrystalClear. Rigaku/MSC Inc., The Woodlands, Texas, USA.]); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); software used to prepare material for publication: SHELXTL.

Supporting information

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810037712/hg2715sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536810037712/hg2715Isup2.hkl

checkCIF report


Comment top

1,2,4-Triazolo[1,5-a]pyrimidine derivatives are known because of their wide range of biological activities. For example, some of the trizaolopyrimidines can be used as anticancer agents (Zhang et al., 2007), inhibitor of the MDM2-p53 protein-protein interaction (Allen et al., 2009), antituberculosis agents (Pereyaslavskaya et al., 2008) and dehydrogenase inhibitors (Gujjar et al., 2009). Therefore, the preparation or structural modification of these nitrogen-containing heterocyclic scaffolds is of considerable interest for both organic and medicinal chemistry. The introduction of a trifluoromethyl group into organic molecules often changes their physical, chemical, and physiological properties (Kirk, 2006). During the synthesis of trifluoromethylated 1,2,4-Triazolo[1,5-a]pyrimidine derivatives, the title compound (I) was isolated and its structure was determined by X-ray analysis. The results are presented here.

In the title molecule (Fig. 1), the 1,2,4-triazole ring adopts a planar conformation. Cremer & Pople puckering analysis (Cremer &Pople, 1975) can not be performed, for its weighted average absolute torsion angle is 0.7°, less than 5.0°. The dihydropyrimidine ring system is in an envelope conformation, for Cremer & Pople puckering analysis shows θ(2) and ϕ(2) are 0.094 (2)Å and 346.4 (10)°, respectively. Its puckering amplitude (Q) is 0.099 (2)Å. Besides, the distance between atom C2 and the mean N2/C1/N1/C4/C3 plane (r.m.s. deviation 0.016 Å) is 0.136 (2) Å, which also confirms the conformation of the dihydropyrimidine ring. The dihedral angle between the aforementioned weighted plane and phenyl ring is 83.94 (6)°, which shows the two units are nearly perpendicular.

The crystal packing is stabilized by intermolecular N—H···N hydrogen bonds (Table 1, Fig.2).

Related literature top

For the anticancer activity, inhibition of the MDM2-p53 protein–protein interaction and the antituberculosis and dehydrogenase inhibitory activity of [1,2,4]triazolo [1,5-a]pyrimidine derivatives, see: Zhang et al. (2007); Allen et al. (2009); Pereyaslavskaya et al. (2008); Gujjar et al. (2009). For the bioactivity of trifluoromethylated molecules, see: Kirk, (2006). For the preparation of trifluoromethylated [1,2,4]triazolo[1,5-a]pyrimidine derivatives, see Pryadeina et al. (2004). For puckering parameters, see: Cremer & Pople (1975).

Experimental top

The title compound was synthesized according the procedure reported by Pryadeina et al. (2004). A mixture of 0.01 mol of ethyl 4,4,4-trifluoro-3-oxobutanoate, 0.01 mol of 2-chlorobenzaldehyde and 0.01 mol of 1H-1,2,4-triazol-5-amine in 20 mL of ethanol containing a catalytic amount of hydrochloric acid was heated for 12 h under reflux. Then the solvent was removed under reduced pressure. The residue was added to a solution of p-toluenesulfonic acid, 0.05 g, in 100 mL of benzene, and the mixture was heated for 8 h with simultaneous removal of water as azeotrope with benzene. The solution was filtered while hot, the filtrate was evaporated, and the precipitate was recrystallized from ethanol. Cooling the ethanol solution slowly gave single crystals suitable for X-ray diffraction.

Refinement top

The H atoms bound to N atoms were located in a difference map and were refined freely [refined N–H length, 0.90 (2)Å]. All other H atoms were placed in calculated positions, with C–H = 0.95, 0.98, 0.99 or 1.00 Å, and included in the final cycles of refinement using a riding model, with Uiso(H) = 1.2Ueq(parent atom). The OCH2CH3 group is disordered over two sites with occupancies of 0.155 (3) and 0.845 (3). The atom pairs of C12 and C12', C13 and C13', and O2 and O2' are constrained to have the same anisotropic displacement parameters. The bond lengths of ethyl group of C12–C13 and C12'–C13' is restrained to 1.54Å with esd of 0.01Å. The distance between O2 and C12, O2' and C12' is restrained to 1.42Å with esd of 0.01Å. The atoms of O2 and O2' are restrained to be at the distance of 1.38Å from the atom of C11 with esd of 0.01Å.

Computing details top

Data collection: CrystalClear (Rigaku/MSC, 2002); cell refinement: CrystalClear (Rigaku/MSC, 2002); data reduction: CrystalClear (Rigaku/MSC, 2002); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. The molecular structure of the title compound, showing 30% probability displacement ellipsoids and the atom-numbering scheme. The minor part of the disordered moieties were omitted for clarity.
[Figure 2] Fig. 2. A packing diagram of the title compound. Intermolecular hydrogen bonds are shown as dashed lines. The minor part of the disordered moieties were omitted for clarity.
Ethyl 7-(2-chlorophenyl)-5-trifluoromethyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carboxylate top
Crystal data top
C15H12ClF3N4O2F(000) = 760
Mr = 372.74Dx = 1.527 Mg m−3
Monoclinic, P21/nMo Kα radiation, λ = 0.71070 Å
Hall symbol: -P 2ynCell parameters from 3832 reflections
a = 9.8927 (12) Åθ = 2.4–27.9°
b = 6.8055 (6) ŵ = 0.29 mm−1
c = 24.403 (3) ÅT = 113 K
β = 99.237 (9)°Block, colorless
V = 1621.6 (3) Å30.26 × 0.22 × 0.20 mm
Z = 4
Data collection top
Rigaku Saturn
diffractometer		3835 independent reflections
Radiation source: rotating anode3058 reflections with I > 2σ(I)
Confocal monochromatorRint = 0.043
Detector resolution: 7.31 pixels mm-1θmax = 27.9°, θmin = 2.4°
ω scansh = −13→13
Absorption correction: multi-scan
CrystalClear		k = −8→8
Tmin = 0.930, Tmax = 0.945l = −32→32
14364 measured reflections
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.047Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.121H atoms treated by a mixture of independent and constrained refinement
S = 1.08 w = 1/[σ2(Fo2) + (0.0596P)2 + 0.2191P]
where P = (Fo2 + 2Fc2)/3
3835 reflections(Δ/σ)max = 0.001
242 parametersΔρmax = 0.27 e Å−3
6 restraintsΔρmin = −0.40 e Å−3
Crystal data top
C15H12ClF3N4O2V = 1621.6 (3) Å3
Mr = 372.74Z = 4
Monoclinic, P21/nMo Kα radiation
a = 9.8927 (12) ŵ = 0.29 mm−1
b = 6.8055 (6) ÅT = 113 K
c = 24.403 (3) Å0.26 × 0.22 × 0.20 mm
β = 99.237 (9)°
Data collection top
Rigaku Saturn
diffractometer		3835 independent reflections
Absorption correction: multi-scan
CrystalClear		3058 reflections with I > 2σ(I)
Tmin = 0.930, Tmax = 0.945Rint = 0.043
14364 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0476 restraints
wR(F2) = 0.121H atoms treated by a mixture of independent and constrained refinement
S = 1.08Δρmax = 0.27 e Å−3
3835 reflectionsΔρmin = −0.40 e Å−3
242 parameters
Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2sigma(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/UeqOcc. (<1)
Cl1−0.02142 (6)1.41310 (7)0.14247 (2)0.04311 (18)
F10.35904 (10)0.54406 (16)0.01321 (5)0.0375 (3)
F20.44949 (11)0.82808 (16)0.01419 (5)0.0334 (3)
F30.47647 (11)0.65227 (16)0.08811 (5)0.0329 (3)
O10.33660 (14)1.2697 (2)0.11875 (6)0.0369 (3)
N10.14288 (14)0.6813 (2)0.03869 (6)0.0211 (3)
N20.00227 (14)0.9257 (2)0.06666 (6)0.0213 (3)
N3−0.13449 (15)0.9673 (2)0.06434 (6)0.0261 (3)
N4−0.10446 (14)0.6764 (2)0.02200 (6)0.0228 (3)
C10.01658 (17)0.7543 (2)0.04212 (7)0.0198 (3)
C20.11062 (17)1.0474 (2)0.09691 (7)0.0205 (3)
H20.10031.18420.08190.025*
C30.24727 (17)0.9649 (2)0.08603 (7)0.0215 (4)
C40.25580 (16)0.7931 (2)0.05905 (7)0.0199 (3)
C50.09913 (17)1.0529 (2)0.15815 (7)0.0217 (4)
C60.04123 (19)1.2105 (3)0.18215 (8)0.0274 (4)
C70.0304 (2)1.2109 (3)0.23816 (8)0.0356 (5)
H7−0.00831.32060.25410.043*
C80.0765 (2)1.0501 (3)0.27056 (8)0.0381 (5)
H80.06901.04900.30890.046*
C90.1329 (2)0.8925 (3)0.24762 (8)0.0355 (5)
H90.16440.78230.27000.043*
C100.14409 (19)0.8941 (3)0.19169 (8)0.0284 (4)
H100.18330.78420.17610.034*
C110.36016 (18)1.1040 (3)0.10611 (7)0.0249 (4)
O20.48511 (16)1.0381 (3)0.10610 (10)0.0390 (6)0.845 (3)
C120.5990 (2)1.1697 (4)0.12467 (11)0.0315 (6)0.845 (3)
H12A0.56781.30770.11990.038*0.845 (3)
H12B0.67211.14890.10190.038*0.845 (3)
C130.6540 (3)1.1316 (5)0.18435 (12)0.0518 (8)0.845 (3)
H13A0.58321.16070.20700.078*0.845 (3)
H13B0.73381.21570.19600.078*0.845 (3)
H13C0.68120.99340.18920.078*0.845 (3)
O2'0.4728 (9)0.9900 (15)0.1298 (5)0.0390 (6)0.155 (3)
C12'0.5996 (11)1.0954 (19)0.1454 (7)0.0315 (6)0.155 (3)
H12C0.58601.20560.17040.038*0.155 (3)
H12D0.63091.14990.11200.038*0.155 (3)
C13'0.7072 (14)0.952 (2)0.1752 (7)0.0518 (8)0.155 (3)
H13D0.68470.91900.21170.078*0.155 (3)
H13E0.79791.01330.17960.078*0.155 (3)
H13F0.70760.83170.15300.078*0.155 (3)
C140.38686 (17)0.7050 (2)0.04419 (7)0.0225 (4)
C15−0.19178 (18)0.8142 (3)0.03716 (7)0.0255 (4)
H15−0.28840.80010.02850.031*
H10.146 (2)0.567 (3)0.0203 (9)0.039 (6)*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
Cl10.0546 (4)0.0261 (3)0.0533 (4)0.0094 (2)0.0228 (3)0.0025 (2)
F10.0217 (6)0.0361 (6)0.0564 (8)−0.0049 (5)0.0118 (5)−0.0233 (5)
F20.0250 (6)0.0366 (6)0.0418 (7)−0.0032 (4)0.0153 (5)0.0102 (5)
F30.0249 (6)0.0370 (6)0.0359 (6)0.0063 (5)0.0023 (5)0.0070 (5)
O10.0310 (8)0.0290 (7)0.0506 (9)−0.0071 (6)0.0063 (6)−0.0098 (6)
N10.0169 (7)0.0207 (7)0.0259 (8)−0.0011 (5)0.0038 (6)−0.0039 (6)
N20.0150 (7)0.0256 (7)0.0231 (7)0.0003 (5)0.0022 (6)−0.0043 (6)
N30.0169 (7)0.0317 (8)0.0293 (8)0.0022 (6)0.0026 (6)−0.0046 (6)
N40.0172 (7)0.0261 (8)0.0245 (8)−0.0008 (6)0.0017 (6)−0.0028 (6)
C10.0175 (8)0.0224 (8)0.0191 (8)−0.0011 (6)0.0022 (6)−0.0002 (6)
C20.0194 (8)0.0210 (8)0.0208 (8)−0.0021 (6)0.0022 (6)−0.0027 (6)
C30.0186 (8)0.0250 (8)0.0207 (8)−0.0015 (7)0.0030 (7)−0.0007 (6)
C40.0168 (8)0.0235 (8)0.0194 (8)−0.0023 (6)0.0030 (6)0.0023 (6)
C50.0177 (8)0.0269 (9)0.0205 (8)−0.0036 (7)0.0027 (7)−0.0028 (7)
C60.0251 (9)0.0283 (9)0.0295 (10)−0.0030 (7)0.0069 (7)−0.0045 (7)
C70.0325 (11)0.0440 (12)0.0329 (11)−0.0062 (9)0.0134 (8)−0.0141 (9)
C80.0311 (11)0.0631 (14)0.0207 (9)−0.0098 (10)0.0057 (8)−0.0034 (9)
C90.0281 (10)0.0525 (12)0.0260 (10)0.0015 (9)0.0043 (8)0.0104 (9)
C100.0249 (9)0.0341 (10)0.0263 (9)0.0022 (8)0.0046 (7)0.0019 (8)
C110.0215 (9)0.0318 (10)0.0217 (9)−0.0031 (7)0.0051 (7)−0.0037 (7)
O20.0174 (8)0.0325 (10)0.0652 (16)−0.0059 (7)0.0001 (8)−0.0180 (10)
C120.0184 (10)0.0282 (14)0.0467 (16)−0.0069 (9)0.0016 (10)−0.0065 (11)
C130.0329 (15)0.070 (2)0.0506 (17)−0.0184 (13)0.0010 (12)−0.0013 (15)
O2'0.0174 (8)0.0325 (10)0.0652 (16)−0.0059 (7)0.0001 (8)−0.0180 (10)
C12'0.0184 (10)0.0282 (14)0.0467 (16)−0.0069 (9)0.0016 (10)−0.0065 (11)
C13'0.0329 (15)0.070 (2)0.0506 (17)−0.0184 (13)0.0010 (12)−0.0013 (15)
C140.0197 (8)0.0227 (8)0.0258 (9)−0.0040 (6)0.0059 (7)−0.0004 (7)
C150.0165 (8)0.0313 (9)0.0282 (9)0.0003 (7)0.0020 (7)−0.0029 (7)
Geometric parameters (Å, º) top
Cl1—C61.7407 (19)C7—H70.9500
F1—C141.3339 (19)C8—C91.369 (3)
F2—C141.3293 (19)C8—H80.9500
F3—C141.326 (2)C9—C101.387 (3)
O1—C111.202 (2)C9—H90.9500
N1—C11.359 (2)C10—H100.9500
N1—C41.377 (2)C11—O21.315 (2)
N1—H10.90 (2)C11—O2'1.404 (8)
N2—C11.329 (2)O2—C121.453 (3)
N2—N31.3744 (19)C12—C131.493 (4)
N2—C21.458 (2)C12—H12A0.9900
N3—C151.314 (2)C12—H12B0.9900
N4—C11.329 (2)C13—H13A0.9800
N4—C151.366 (2)C13—H13B0.9800
C2—C51.517 (2)C13—H13C0.9800
C2—C31.526 (2)O2'—C12'1.442 (9)
C2—H21.0000C12'—C13'1.539 (9)
C3—C41.351 (2)C12'—H12C0.9900
C3—C111.486 (2)C12'—H12D0.9900
C4—C141.524 (2)C13'—H13D0.9800
C5—C101.385 (2)C13'—H13E0.9800
C5—C61.389 (2)C13'—H13F0.9800
C6—C71.388 (3)C15—H150.9500
C7—C81.384 (3)
C1—N1—C4118.45 (14)C5—C10—C9121.27 (18)
C1—N1—H1116.7 (14)C5—C10—H10119.4
C4—N1—H1124.6 (14)C9—C10—H10119.4
C1—N2—N3109.72 (13)O1—C11—O2122.77 (17)
C1—N2—C2127.16 (14)O1—C11—O2'125.9 (5)
N3—N2—C2122.86 (13)O2—C11—O2'29.2 (5)
C15—N3—N2101.51 (14)O1—C11—C3121.07 (16)
C1—N4—C15101.41 (14)O2—C11—C3116.05 (16)
N4—C1—N2111.19 (15)O2'—C11—C3106.8 (4)
N4—C1—N1127.88 (15)C11—O2—C12118.11 (18)
N2—C1—N1120.91 (15)O2—C12—C13109.9 (2)
N2—C2—C5110.32 (13)O2—C12—H12A109.7
N2—C2—C3107.61 (13)C13—C12—H12A109.7
C5—C2—C3112.88 (14)O2—C12—H12B109.7
N2—C2—H2108.6C13—C12—H12B109.7
C5—C2—H2108.6H12A—C12—H12B108.2
C3—C2—H2108.6C11—O2'—C12'115.7 (8)
C4—C3—C11127.56 (16)O2'—C12'—C13'108.4 (10)
C4—C3—C2121.99 (15)O2'—C12'—H12C110.0
C11—C3—C2110.36 (14)C13'—C12'—H12C110.0
C3—C4—N1122.93 (16)O2'—C12'—H12D110.0
C3—C4—C14125.36 (15)C13'—C12'—H12D110.0
N1—C4—C14111.62 (14)H12C—C12'—H12D108.4
C10—C5—C6117.92 (16)C12'—C13'—H13D109.5
C10—C5—C2119.70 (15)C12'—C13'—H13E109.5
C6—C5—C2122.36 (15)H13D—C13'—H13E109.5
C7—C6—C5121.26 (18)C12'—C13'—H13F109.5
C7—C6—Cl1117.98 (15)H13D—C13'—H13F109.5
C5—C6—Cl1120.75 (14)H13E—C13'—H13F109.5
C8—C7—C6119.36 (18)F3—C14—F2107.78 (13)
C8—C7—H7120.3F3—C14—F1106.64 (14)
C6—C7—H7120.3F2—C14—F1106.11 (14)
C9—C8—C7120.29 (18)F3—C14—C4113.45 (14)
C9—C8—H8119.9F2—C14—C4111.87 (14)
C7—C8—H8119.9F1—C14—C4110.60 (13)
C8—C9—C10119.89 (19)N3—C15—N4116.16 (15)
C8—C9—H9120.1N3—C15—H15121.9
C10—C9—H9120.1N4—C15—H15121.9
C1—N2—N3—C15−0.87 (18)C2—C5—C6—Cl1−0.2 (2)
C2—N2—N3—C15−175.36 (15)C5—C6—C7—C8−0.9 (3)
C15—N4—C1—N2−0.70 (18)Cl1—C6—C7—C8178.59 (15)
C15—N4—C1—N1−179.05 (17)C6—C7—C8—C90.3 (3)
N3—N2—C1—N41.04 (19)C7—C8—C9—C100.1 (3)
C2—N2—C1—N4175.24 (15)C6—C5—C10—C9−0.5 (3)
N3—N2—C1—N1179.53 (15)C2—C5—C10—C9−178.84 (16)
C2—N2—C1—N1−6.3 (3)C8—C9—C10—C50.0 (3)
C4—N1—C1—N4175.37 (16)C4—C3—C11—O1163.90 (19)
C4—N1—C1—N2−2.8 (2)C2—C3—C11—O1−12.7 (2)
C1—N2—C2—C5−112.47 (18)C4—C3—C11—O2−12.5 (3)
N3—N2—C2—C561.02 (19)C2—C3—C11—O2170.95 (18)
C1—N2—C2—C311.1 (2)C4—C3—C11—O2'−42.3 (6)
N3—N2—C2—C3−175.44 (14)C2—C3—C11—O2'141.1 (6)
N2—C2—C3—C4−8.1 (2)O1—C11—O2—C122.9 (3)
C5—C2—C3—C4113.82 (18)O2'—C11—O2—C12−103.3 (10)
N2—C2—C3—C11168.67 (13)C3—C11—O2—C12179.19 (18)
C5—C2—C3—C11−69.36 (18)C11—O2—C12—C1396.5 (3)
C11—C3—C4—N1−175.26 (16)O1—C11—O2'—C12'−35.7 (14)
C2—C3—C4—N11.0 (3)O2—C11—O2'—C12'58.5 (11)
C11—C3—C4—C140.8 (3)C3—C11—O2'—C12'172.2 (10)
C2—C3—C4—C14177.07 (15)C11—O2'—C12'—C13'174.9 (12)
C1—N1—C4—C35.2 (2)C3—C4—C14—F366.0 (2)
C1—N1—C4—C14−171.36 (14)N1—C4—C14—F3−117.51 (15)
N2—C2—C5—C1077.54 (19)C3—C4—C14—F2−56.2 (2)
C3—C2—C5—C10−42.9 (2)N1—C4—C14—F2120.30 (15)
N2—C2—C5—C6−100.70 (18)C3—C4—C14—F1−174.22 (16)
C3—C2—C5—C6138.88 (17)N1—C4—C14—F12.25 (19)
C10—C5—C6—C70.9 (3)N2—N3—C15—N40.5 (2)
C2—C5—C6—C7179.21 (16)C1—N4—C15—N30.1 (2)
C10—C5—C6—Cl1−178.49 (13)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N1—H1···N4i0.90 (2)1.96 (2)2.843 (2)166.3 (19)
Symmetry code: (i) −x, −y+1, −z.

Experimental details

Crystal data
Chemical formulaC15H12ClF3N4O2
Mr372.74
Crystal system, space groupMonoclinic, P21/n
Temperature (K)113
a, b, c (Å)9.8927 (12), 6.8055 (6), 24.403 (3)
β (°) 99.237 (9)
V (Å3)1621.6 (3)
Z4
Radiation typeMo Kα
µ (mm−1)0.29
Crystal size (mm)0.26 × 0.22 × 0.20
Data collection
DiffractometerRigaku Saturn
diffractometer
Absorption correctionMulti-scan
CrystalClear
Tmin, Tmax0.930, 0.945
No. of measured, independent and
observed [I > 2σ(I)] reflections		14364, 3835, 3058
Rint0.043
(sin θ/λ)max (Å−1)0.658
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.047, 0.121, 1.08
No. of reflections3835
No. of parameters242
No. of restraints6
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å−3)0.27, −0.40

Computer programs: CrystalClear (Rigaku/MSC, 2002), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), SHELXTL (Sheldrick, 2008).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N1—H1···N4i0.90 (2)1.96 (2)2.843 (2)166.3 (19)
Symmetry code: (i) −x, −y+1, −z.
 

Acknowledgements

This work was supported by the Special Fund for the President's Project (Project 2009 KJZ20) of Xuzhou Medical College.

References

First citationAllen, J. G., Bourbeau, M. P., Wohlhieter, G. E., Bartberger, M. D., Michelsen, K., Hungate, R., Gadwood, R. C., Gaston, R. D., Evans, B., Mann, L. W., Matison, M. E., Schneider, S., Huang, X., Yu, D. Y., Andrews, P. S., Reichelt, A., Long, A. M., Yakowec, P., Yang, E. Y., Lee, T. A. & Oliner, J. D. (2009). J. Med. Chem. 52, 7044–7053.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationCremer, D. & Pople, J. A. (1975). J. Am. Chem. Soc. 97, 1354–1358.  CrossRef CAS Web of Science Google Scholar
 First citationGujjar, R., Marwaha, A., El Mazouni, F., White, J., White, K. L., Creason, S., Shackleford, D. M., Baldwin, J., Charman, W. N., Buckner, F. S., Charman, S., Rathod, P. K. & Phillips, M. A. (2009). J. Med. Chem. 52, 1864–1872.  Web of Science CrossRef PubMed CAS Google Scholar
 First citationKirk, K. L. (2006). J. Fluorine Chem. 127,1013–1029.  Web of Science CrossRef CAS Google Scholar
 First citationPereyaslavskaya, E. S., Potemkin, V. A., Bartashevich, E. V., Grishina, M. A., Rusinov, G. L., Fedorova, O. V., Zhidovinova, M. S. & Ovchinnikova, I. G. (2008). Pharm. Chem. J. 42, 622–625.  CrossRef CAS Google Scholar
 First citationPryadeina, M. V., Burgart, Ya. V., Saloutin, V. I., Kodess, M. I., Ulomskii, E. N. & Rusinov, V. L. (2004). Russ. J. Org. Chem. 40, 902–907.  Web of Science CrossRef CAS Google Scholar
 First citationRigaku/MSC (2002). CrystalClear. Rigaku/MSC Inc., The Woodlands, Texas, USA.  Google Scholar
 First citationSheldrick, G. M. (2008). Acta Cryst. A64, 112–122.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationZhang, N., Ayral-Kaloustian, S., Nguyen, T., Afragola, J., Hernandez, R., Lucas, J., Gibbons, J. & Beyer, C. (2007). J. Med. Chem. 50, 319–327.  Web of Science CrossRef PubMed CAS Google Scholar

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 10| October 2010| Page o2642
doi:10.1107/S1600536810037712
Follow Acta Cryst. E
Sign up for e-alerts
E-alerts
Follow Acta Cryst. on Twitter
Twitter
Follow us on facebook
Facebook
Sign up for RSS feeds
RSS