3-Chloro-4-dimethyl­amino-5-[(1R,2S,5R)-2-isopropyl-5-methyl­cyclo­hex­yloxy]furan-2(5H)-one

Song, X.-M.; Wang, N.; Wang, Z.-Y.; Feng, Z.-C.

doi:10.1107/S1600536811015583

organic compounds

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ISSN: 2056-9890

Volume 67| Part 6| June 2011| Pages o1485-o1486

doi:10.1107/S1600536811015583

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3-Chloro-4-dimethylamino-5-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]furan-2(5H)-one

Xiu-Mei Song,^a,^b,^c,^d ^* Ning Wang,^e Zhao-Yang Wang ^d and Zong-Cai Feng ^a,^b,^c

^aResearch Center of Chemistry & Materials, Zhanjiang Normal College, People's Republic of China, ^bDevelopment Center for New Materials Engineering &, Technology in Universities of Guangdong, People's Republic of China, ^cChemistry Science & Technology School, Zhanjiang Normal College, Zhanjiang 524048, People's Republic of China, ^dSchool of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China, and ^eResearch Institute of Tsinghua University in Shenzhen, Shenzhen 518055, People's Republic of China
^*Correspondence e-mail: sxmfn@163.com

(Received 5 April 2011; accepted 25 April 2011; online 20 May 2011)

The title compound, C₁₆H₂₆ClNO₃ contains one almost planar furanone ring [maximum deviation of 0.021 (2) Å for the O atom] with a stereogenic center (S) and one cyclohexane ring which displays a chair conformation and has three stereogenic centers [S at the C atom bearing the isopropyl group, R at the C atom attached to the O atom and R at the C atom bearing the methyl group].

Related literature

For natural products containing a 2(5H)-furanone subunit, see: Ming et al. (2002 ). For biologically active 2(5H)-furanones, see: Bailly et al. (2008 ). For the synthesis of 2(5H)-furanones with substituents in positions 3 and 4, see: Van Oeveren et al. (1994 ); For related structures, see: Chen et al. (1995 ); Martín & Mateo (1995 ); Gawronski et al. (1997 ). For the use of benzimidazoles in organic synthesis, see: Mao et al. (2010 ). For standard bond lengths, see: Allen et al. (1987 ); Orpen et al. (1989 ). For the structures of heterosubstituted 2(5H)-furanones, see: Gawronski et al. (1997). For the synthesis and structure of optically pure 5-(l-menthyloxy)-3,4-dichloro-2(5H)-furanone, see: Chen & Geng (1993 ). For a description of the Cambridge Structural Database, see: Allen (2002 ).

Experimental

Crystal data

C₁₆H₂₆ClNO₃
M_r = 315.83
Orthorhombic, P 2₁ 2₁ 2₁
a = 7.5438 (5) Å
b = 8.1631 (5) Å
c = 28.5953 (17) Å
V = 1760.92 (19) Å³
Z = 4
Mo Kα radiation
μ = 0.23 mm⁻¹
T = 296 K
0.23 × 0.22 × 0.19 mm

Data collection

Bruker APEXII area-detector diffractometer
Absorption correction: multi-scan (SADABS; Sheldrick, 1996 ) T_min = 0.950, T_max = 0.958
9112 measured reflections
2922 independent reflections
1951 reflections with I > 2σ(I)
R_int = 0.049

Refinement

R[F² > 2σ(F²)] = 0.047
wR(F²) = 0.117
S = 1.02
2922 reflections
196 parameters
H-atom parameters constrained
Δρ_max = 0.15 e Å⁻³
Δρ_min = −0.14 e Å⁻³
Absolute structure: Flack (1983 ), 1066 Friedel pairs
Flack parameter: −0.05 (9)

Data collection: APEX2 (Bruker, 2004 ); cell refinement: SAINT (Bruker, 2004); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXL97.

Supporting information

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536811015583/si2350sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536811015583/si2350Isup2.hkl

Supporting information file. DOI: 10.1107/S1600536811015583/si2350Isup3.cml

checkCIF report

Comment top

2(5H)-Furanones, also known as crotonolactones or butenolides, have attracted increasing attention of many organic chemists due to their presence as a subunit in many natural products (Ming et al., 2002). This core unit is the key structure to induce a variety of biological phenomena like antifungal, anti-inflamatory, antibacterial, and HIV-1 anti-integrase (Bailly et al., 2008). In recent years, chiral 2(5H)-furanones with substituents in positions 3 and 4 have been synthesized in several laboratories (Van Oeveren et al., 1994) and their crystal structures have been reported (Chen et al., 1995; Martín & Mateo, 1995; Gawronski et al., 1997).

Meanwhile, benzimidazoles were widely used in various areas, especially serving as key intermediate in organic synthesis (Mao et al., 2010). In our initial study, we focused on the Michael addition-elimination reaction of 3,4-dichloro-5-(S)-(l-menthyloxy)-2(5H)-furanone and nucleophilic reagent imidazole. On the basis of the experiment, no target molecule was obtained, but the unexpected product, 3-chloro-4-N,N-dimethyl-5-(S)-(l-menthyloxy)-2(5H)-furanone that came from reaction of 3,4-dichloro-5-(S)-(l-menthyloxy)-2(5H)-furanone and the solvent N,N-dimethylformamide was given.

In the title compound (Fig. 1), the cyclohexane ring displays a chair conformation and has three stereogenic centers (C2(S), C3(R), C5(R)), and the planar core structure subunit, the furanone ring exhibits a C16(S) center with a maximum deviation of 0.021 (2) Å of O2 from the mean plane of the five atoms defining the plane, r.m.s deviation is 0.0158 Å.

Cl substitution at C14 causes significant torsion around the C13—N1 bond. The C14—C13—N1—C12 torsion angle amounts to 5.2 (5)°, this indicates a significant twist around the C13—N1 bond resulting from Cl substitution at C14.

At the same time, N1 is only 0.034 (5) Å from the furanone ring plane. This is one manifestation of the extensive conjugation of the N1 lone pair, the C13═C14 double bond and the C15 carbonyl bond. The geometrical consequence is a shortening of the N1—C13 bond to an value of 1.331 (3) Å, which might be compared with the average value of 1.355 (14) Å for the C—N bond in C═C—N—(C)₂ system (Orpen et al., 1989; Gawronski et al., 1997). The shortening of the N1—C13 bond is accompanied by the lengthening of the formally C13═C14 double bond to an value of 1.354 (3) Å, as compared with the value of 1.323 (13) Å quoted for cyclopentene and with 1.340 (13) Å in conjugated systems (Orpen et al., 1989).

And the most striking geometrical change due to conjugation is found in the furanone ring. Comparison with the non-fused furanones which contain oxygen function at C(4) (22 observations subtracted from the Cambridge Structural Database 14) (Allen, 2002) reveals significant shortening of the formally single C(sp²)—C(sp²) bond to an value of 1.428 (4) Å and simultaneous lengthening of the C(carbonyl)—O bond to an value of 1.373 (3) Å. In non-fused furanones the two bonds have the mean values of 1.466 (26) Å and 1.362 (16) Å, respectively (Allen et al., 1987; Gawronski et al., 1997). This might indicate that the essential part of the electron delocalization is concentrated in the N1, C13, C14, C15 and O3 region, and takes place at the expense of delocalization within the ester function.

Related literature top

For natural products containing a 2(5H)-furanone subunit, see: Ming et al. (2002). For biologically active 2(5H)-furanones, see: Bailly et al. (2008). For the synthesis of 2(5H)-furanones with substituents in positions 3 and 4, see: Van Oeveren et al. (1994); For related structures, see: Chen et al. (1995); Martín & Mateo (1995); Gawronski et al. (1997). For the use of benzimidazoles in organic synthesis, see: Mao et al. (2010). For standard bond lengths, see: Allen et al. (1987); Orpen et al. (1989). For the structures of heterosubstituted 2(5H)-furanones, see: Gawronski et al. (1997). For the synthesis and structure of optically pure 5-(l-menthyloxy)-3,4-dichloro-2(5H)-furanone, see: Chen & Geng (1993). For a description of the Cambridge Structural Database, see: Allen (2002).

Experimental top

The optically pure precursor 3,4-dichloro-5-(S)-(l-menthyloxy)-2(5H)-furanone was prepared according to the literature procedure (Chen & Geng, 1993).

The title compond, 3-chloro-4-N,N-dimethyl-5-(S)-(l-menthyloxy)-2(5H)-furanone, was prepared by reaction of 3,4-dichloro-5-(S)-(l-menthyloxy)-2(5H)-furanone (3 mmol) and DMF (1 ml) at 80 °C, catalyzed by sodium ethanol (3 mmol) under N₂ atmosphere. After stirring for 24 h, ice water was added to the mixture and then extracted by dichloromethane. The solvent was evaporated in vacuo and the precipitate was purified by silica gel column chromatography with gradient mixture of petroleum ether and ethyl acetate (Yield 21.3%). Single crystals of the title compound were obtained by slow evaporation of a solution in acetonitrile at room temperature.

Data for (I): m.p.161.0–163.0 °C; IR (KBr) ν: 2953.73, 748.40, 1630.61 cm^-1; ¹H NMR (400 MHz, CDCl₃, TMS): 0.762 (3H, d, J = 6.8 Hz, CH₃-7), 0.820–0.858 (1H, m, CH-8), 0.909 (3H, s, CH₃-9), 0.926 (3H, s, CH₃-10), 0.956–1.170 (2H, m, CH₂-6), 1.290–1.427 (2H, m, CH-2, CH-5), 1.633–1.695 (2H, m, CH₂-1), 2.171–2.211 (2H, m, CH₂-4), 3.186 (6H, s, CH₃-11, CH₃-12), 3.532–3.845 (1H, ddd, J = 4.4 Hz, 4.4 Hz, 4.4 Hz, CH-3), 5.757 (1H, s, CH-16).

Computing details top

Data collection: APEX2 (Bruker, 2004); cell refinement: SAINT (Bruker, 2004); data reduction: SAINT (Bruker, 2004); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008).

Figures top

Fig. 1. The molecular structure of the title compound. Displacement ellipsoids drawn at the 30% probability level, hydrogen atoms have been omitted for clarity.

3-Chloro-4-dimethylamino-5-[(1R,2S,5R)-2-isopropyl- 5-methylcyclohexyloxy]furan-2(5H)-one top

Crystal data top

C₁₆H₂₆ClNO₃	F(000) = 680
M_r = 315.83	D_x = 1.191 Mg m⁻³
Orthorhombic, P2₁2₁2₁	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 3099 reflections
a = 7.5438 (5) Å	θ = 2.8–20.5°
b = 8.1631 (5) Å	µ = 0.23 mm⁻¹
c = 28.5953 (17) Å	T = 296 K
V = 1760.92 (19) Å³	Block, colourless
Z = 4	0.23 × 0.22 × 0.19 mm

Data collection top

Bruker APEXII area-detector diffractometer	2922 independent reflections
Radiation source: fine-focus sealed tube	1951 reflections with I > 2σ(I)
Graphite monochromator	R_int = 0.049
ϕ and ω scans	θ_max = 25.2°, θ_min = 1.4°
Absorption correction: multi-scan (SADABS; Sheldrick, 1996)	h = −8→7
T_min = 0.950, T_max = 0.958	k = −9→6
9112 measured reflections	l = −23→34

Refinement top

Refinement on F²	Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: full	H-atom parameters constrained
R[F² > 2σ(F²)] = 0.047	w = 1/[σ²(F_o²) + (0.055P)²] where P = (F_o² + 2F_c²)/3
wR(F²) = 0.117	(Δ/σ)_max < 0.001
S = 1.02	Δρ_max = 0.15 e Å⁻³
2922 reflections	Δρ_min = −0.14 e Å⁻³
196 parameters	Extinction correction: SHELXL97 (Sheldrick, 2008), Fc^*=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4
0 restraints	Extinction coefficient: 0.016 (2)
Primary atom site location: structure-invariant direct methods	Absolute structure: Flack (1983), 1066 Friedel pairs
Secondary atom site location: difference Fourier map	Absolute structure parameter: −0.05 (9)

Crystal data top

C₁₆H₂₆ClNO₃	V = 1760.92 (19) Å³
M_r = 315.83	Z = 4
Orthorhombic, P2₁2₁2₁	Mo Kα radiation
a = 7.5438 (5) Å	µ = 0.23 mm⁻¹
b = 8.1631 (5) Å	T = 296 K
c = 28.5953 (17) Å	0.23 × 0.22 × 0.19 mm

Data collection top

Bruker APEXII area-detector diffractometer	2922 independent reflections
Absorption correction: multi-scan (SADABS; Sheldrick, 1996)	1951 reflections with I > 2σ(I)
T_min = 0.950, T_max = 0.958	R_int = 0.049
9112 measured reflections

Refinement top

R[F² > 2σ(F²)] = 0.047	H-atom parameters constrained
wR(F²) = 0.117	Δρ_max = 0.15 e Å⁻³
S = 1.02	Δρ_min = −0.14 e Å⁻³
2922 reflections	Absolute structure: Flack (1983), 1066 Friedel pairs
196 parameters	Absolute structure parameter: −0.05 (9)
0 restraints

Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > σ(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
C1	0.4580 (5)	0.8674 (4)	0.45480 (10)	0.0785 (11)
H1A	0.3934	0.7827	0.4714	0.094*
H1B	0.5740	0.8773	0.4691	0.094*
C2	0.4806 (4)	0.8152 (4)	0.40327 (9)	0.0628 (9)
H2	0.5491	0.9020	0.3880	0.075*
C3	0.2995 (4)	0.8133 (3)	0.37990 (9)	0.0525 (8)
H3	0.2272	0.7270	0.3942	0.063*
C4	0.2051 (5)	0.9754 (3)	0.38525 (9)	0.0701 (10)
H4A	0.0895	0.9685	0.3705	0.084*
H4B	0.2724	1.0599	0.3693	0.084*
C5	0.1815 (6)	1.0237 (4)	0.43669 (11)	0.0804 (11)
H5	0.1112	0.9379	0.4519	0.096*
C6	0.3610 (7)	1.0271 (4)	0.45991 (11)	0.0893 (12)
H6A	0.4316	1.1140	0.4462	0.107*
H6B	0.3462	1.0514	0.4929	0.107*
C7	0.0799 (7)	1.1841 (5)	0.44127 (12)	0.1207 (16)
H7A	0.0713	1.2137	0.4737	0.181*
H7B	−0.0369	1.1710	0.4285	0.181*
H7C	0.1413	1.2688	0.4245	0.181*
C8	0.5869 (5)	0.6562 (4)	0.39706 (11)	0.0718 (10)
H8	0.5775	0.6257	0.3640	0.086*
C9	0.5161 (5)	0.5122 (4)	0.42518 (12)	0.0989 (14)
H9A	0.5293	0.5345	0.4580	0.148*
H9B	0.5814	0.4151	0.4173	0.148*
H9C	0.3930	0.4960	0.4181	0.148*
C10	0.7855 (5)	0.6823 (6)	0.40726 (13)	0.1098 (14)
H10A	0.8276	0.7752	0.3899	0.165*
H10B	0.8507	0.5865	0.3981	0.165*
H10C	0.8019	0.7016	0.4401	0.165*
C11	0.2476 (5)	0.4116 (4)	0.31317 (11)	0.0793 (11)
H11A	0.3620	0.3966	0.3272	0.119*
H11B	0.1923	0.3069	0.3087	0.119*
H11C	0.1751	0.4777	0.3333	0.119*
C12	0.3298 (6)	0.3891 (4)	0.23027 (11)	0.0928 (12)
H12A	0.2355	0.3726	0.2082	0.139*
H12B	0.3670	0.2853	0.2426	0.139*
H12C	0.4280	0.4411	0.2149	0.139*
C13	0.2303 (4)	0.6503 (3)	0.26159 (9)	0.0495 (7)
C14	0.2256 (4)	0.7458 (3)	0.22286 (9)	0.0530 (8)
C15	0.1758 (4)	0.9092 (4)	0.23489 (11)	0.0588 (8)
C16	0.1844 (4)	0.7605 (3)	0.30258 (10)	0.0529 (8)
H16	0.0818	0.7180	0.3198	0.063*
Cl1	0.26385 (14)	0.70164 (12)	0.16516 (3)	0.0940 (4)
N1	0.2678 (3)	0.4928 (3)	0.26825 (8)	0.0609 (7)
O1	0.3317 (3)	0.7719 (2)	0.33142 (6)	0.0524 (5)
O2	0.1456 (3)	0.9169 (2)	0.28218 (6)	0.0627 (6)
O3	0.1584 (3)	1.0295 (3)	0.21086 (7)	0.0817 (7)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.098 (3)	0.095 (3)	0.0424 (19)	−0.022 (2)	−0.0045 (19)	−0.0019 (18)
C2	0.075 (3)	0.077 (2)	0.0371 (18)	−0.022 (2)	−0.0020 (17)	0.0055 (15)
C3	0.062 (2)	0.0594 (16)	0.0362 (16)	−0.0128 (16)	0.0064 (15)	−0.0012 (12)
C4	0.095 (3)	0.0667 (18)	0.0485 (18)	−0.0030 (19)	0.0067 (19)	−0.0073 (14)
C5	0.116 (4)	0.075 (2)	0.050 (2)	0.001 (2)	0.010 (2)	−0.0140 (16)
C6	0.137 (4)	0.086 (2)	0.045 (2)	−0.017 (3)	0.002 (2)	−0.0115 (18)
C7	0.174 (4)	0.106 (3)	0.082 (3)	0.036 (3)	0.010 (3)	−0.038 (2)
C8	0.070 (3)	0.093 (3)	0.053 (2)	−0.005 (2)	−0.0094 (19)	0.0014 (18)
C9	0.118 (4)	0.096 (3)	0.083 (3)	0.003 (3)	−0.010 (3)	0.025 (2)
C10	0.069 (3)	0.178 (4)	0.083 (3)	−0.002 (3)	−0.016 (2)	0.003 (3)
C11	0.090 (3)	0.0654 (17)	0.082 (2)	0.004 (2)	−0.013 (2)	0.0145 (17)
C12	0.101 (3)	0.078 (2)	0.099 (3)	0.025 (2)	−0.005 (2)	−0.029 (2)
C13	0.047 (2)	0.0554 (16)	0.0464 (16)	−0.0003 (15)	−0.0049 (16)	−0.0037 (14)
C14	0.052 (2)	0.0640 (17)	0.0426 (18)	−0.0003 (15)	−0.0025 (15)	−0.0071 (14)
C15	0.052 (2)	0.0674 (19)	0.057 (2)	−0.0010 (17)	−0.0063 (18)	0.0047 (17)
C16	0.057 (2)	0.0535 (16)	0.0482 (17)	−0.0012 (15)	−0.0009 (17)	−0.0027 (14)
Cl1	0.1203 (10)	0.1131 (7)	0.0485 (5)	0.0028 (6)	0.0062 (5)	−0.0091 (4)
N1	0.065 (2)	0.0527 (13)	0.0646 (16)	0.0081 (13)	−0.0033 (15)	−0.0077 (12)
O1	0.0491 (14)	0.0721 (11)	0.0360 (10)	−0.0039 (10)	−0.0030 (10)	−0.0042 (9)
O2	0.0772 (17)	0.0524 (11)	0.0586 (14)	0.0124 (11)	−0.0053 (12)	−0.0035 (10)
O3	0.0903 (19)	0.0725 (13)	0.0823 (16)	0.0021 (13)	−0.0102 (15)	0.0247 (12)

Geometric parameters (Å, º) top

C1—C6	1.502 (5)	C9—H9A	0.9600
C1—C2	1.544 (4)	C9—H9B	0.9600
C1—H1A	0.9700	C9—H9C	0.9600
C1—H1B	0.9700	C10—H10A	0.9600
C2—C3	1.521 (4)	C10—H10B	0.9600
C2—C8	1.536 (5)	C10—H10C	0.9600
C2—H2	0.9800	C11—N1	1.453 (3)
C3—O1	1.447 (3)	C11—H11A	0.9600
C3—C4	1.511 (4)	C11—H11B	0.9600
C3—H3	0.9800	C11—H11C	0.9600
C4—C5	1.533 (4)	C12—N1	1.454 (4)
C4—H4A	0.9700	C12—H12A	0.9600
C4—H4B	0.9700	C12—H12B	0.9600
C5—C6	1.509 (6)	C12—H12C	0.9600
C5—C7	1.523 (5)	C13—N1	1.331 (3)
C5—H5	0.9800	C13—C14	1.354 (3)
C6—H6A	0.9700	C13—C16	1.518 (4)
C6—H6B	0.9700	C14—C15	1.428 (4)
C7—H7A	0.9600	C14—Cl1	1.713 (3)
C7—H7B	0.9600	C15—O3	1.205 (3)
C7—H7C	0.9600	C15—O2	1.373 (3)
C8—C9	1.521 (4)	C16—O1	1.387 (3)
C8—C10	1.541 (5)	C16—O2	1.434 (3)
C8—H8	0.9800	C16—H16	0.9800

C6—C1—C2	112.7 (3)	C2—C8—H8	106.8
C6—C1—H1A	109.0	C10—C8—H8	106.8
C2—C1—H1A	109.0	C8—C9—H9A	109.5
C6—C1—H1B	109.0	C8—C9—H9B	109.5
C2—C1—H1B	109.0	H9A—C9—H9B	109.5
H1A—C1—H1B	107.8	C8—C9—H9C	109.5
C3—C2—C8	114.2 (3)	H9A—C9—H9C	109.5
C3—C2—C1	108.8 (3)	H9B—C9—H9C	109.5
C8—C2—C1	113.7 (3)	C8—C10—H10A	109.5
C3—C2—H2	106.5	C8—C10—H10B	109.5
C8—C2—H2	106.5	H10A—C10—H10B	109.5
C1—C2—H2	106.5	C8—C10—H10C	109.5
O1—C3—C4	112.3 (2)	H10A—C10—H10C	109.5
O1—C3—C2	105.8 (2)	H10B—C10—H10C	109.5
C4—C3—C2	111.7 (3)	N1—C11—H11A	109.5
O1—C3—H3	109.0	N1—C11—H11B	109.5
C4—C3—H3	109.0	H11A—C11—H11B	109.5
C2—C3—H3	109.0	N1—C11—H11C	109.5
C3—C4—C5	112.1 (2)	H11A—C11—H11C	109.5
C3—C4—H4A	109.2	H11B—C11—H11C	109.5
C5—C4—H4A	109.2	N1—C12—H12A	109.5
C3—C4—H4B	109.2	N1—C12—H12B	109.5
C5—C4—H4B	109.2	H12A—C12—H12B	109.5
H4A—C4—H4B	107.9	N1—C12—H12C	109.5
C6—C5—C7	113.5 (3)	H12A—C12—H12C	109.5
C6—C5—C4	108.8 (3)	H12B—C12—H12C	109.5
C7—C5—C4	111.2 (3)	N1—C13—C14	132.7 (3)
C6—C5—H5	107.7	N1—C13—C16	120.7 (2)
C7—C5—H5	107.7	C14—C13—C16	106.5 (2)
C4—C5—H5	107.7	C13—C14—C15	110.3 (2)
C1—C6—C5	112.2 (3)	C13—C14—Cl1	131.5 (2)
C1—C6—H6A	109.2	C15—C14—Cl1	118.2 (2)
C5—C6—H6A	109.2	O3—C15—O2	120.4 (3)
C1—C6—H6B	109.2	O3—C15—C14	130.7 (3)
C5—C6—H6B	109.2	O2—C15—C14	108.9 (2)
H6A—C6—H6B	107.9	O1—C16—O2	110.2 (2)
C5—C7—H7A	109.5	O1—C16—C13	108.4 (2)
C5—C7—H7B	109.5	O2—C16—C13	105.1 (2)
H7A—C7—H7B	109.5	O1—C16—H16	111.0
C5—C7—H7C	109.5	O2—C16—H16	111.0
H7A—C7—H7C	109.5	C13—C16—H16	111.0
H7B—C7—H7C	109.5	C13—N1—C11	123.0 (2)
C9—C8—C2	114.1 (3)	C13—N1—C12	121.6 (3)
C9—C8—C10	110.4 (3)	C11—N1—C12	115.4 (2)
C2—C8—C10	111.6 (3)	C16—O1—C3	116.8 (2)
C9—C8—H8	106.8	C15—O2—C16	109.0 (2)

Experimental details

Crystal data
Chemical formula	C₁₆H₂₆ClNO₃
M_r	315.83
Crystal system, space group	Orthorhombic, P2₁2₁2₁
Temperature (K)	296
a, b, c (Å)	7.5438 (5), 8.1631 (5), 28.5953 (17)
V (Å³)	1760.92 (19)
Z	4
Radiation type	Mo Kα
µ (mm⁻¹)	0.23
Crystal size (mm)	0.23 × 0.22 × 0.19

Data collection
Diffractometer	Bruker APEXII area-detector diffractometer
Absorption correction	Multi-scan (SADABS; Sheldrick, 1996)
T_min, T_max	0.950, 0.958
No. of measured, independent and observed [I > 2σ(I)] reflections	9112, 2922, 1951
R_int	0.049
(sin θ/λ)_max (Å⁻¹)	0.599

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.047, 0.117, 1.02
No. of reflections	2922
No. of parameters	196
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.15, −0.14
Absolute structure	Flack (1983), 1066 Friedel pairs
Absolute structure parameter	−0.05 (9)

Computer programs: APEX2 (Bruker, 2004), SAINT (Bruker, 2004), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), SHELXTL (Sheldrick, 2008).

Acknowledgements

The work was supported by the National Natural Science Foundation of China (grant No. 20772035) and the Natural Science Foundation of Guangdong Province, China (grant No. 5300082).

References

Allen, F. H. (2002). Acta Cryst. B58, 380–388. Web of Science CrossRef CAS IUCr Journals Google Scholar
Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1–19. CrossRef Google Scholar
Bailly, F., Queffélec, C., Mbemba, G., Mouscadet, J. F., Pommery, N., Pommery, J., Hénichart, J. P. & Cotelle, P. (2008). Eur. J. Med. Chem. 43, 1222–1229. Web of Science CrossRef PubMed CAS Google Scholar
Bruker (2004). APEX2 and SAINT. Bruker AXS Inc., Madison, Wisconsin USA. Google Scholar
Chen, Q.-H. & Geng, Z. (1993). Acta Chim. Sinica, 51, 622–624. CAS Google Scholar
Chen, Q.-H., Geng, Z. & Huang, B. (1995). Tetrahedron Asymmetry, 6, 401–404. CrossRef CAS Google Scholar
Flack, H. D. (1983). Acta Cryst. A39, 876–881. CrossRef CAS Web of Science IUCr Journals Google Scholar
Gawronski, J. K., Chen, Q.-H., Geng, Z., Huang, B., Martin, M. R., Mateo, A. I., Brzostowska, M., Chlewska, R. R. & Feringa, B. L. (1997). Chirality, 9, 537–544. CrossRef CAS Google Scholar
Mao, Z.-Z., Wang, Z.-Y., Li, J.-N., Song, X.-M. & Lou, Y.-F. (2010). Synth. Commun. 40, 1963–1977. CrossRef CAS Google Scholar
Martín, M. R. & Mateo, A. I. (1995). Tetrahedron Asymmetry, 6, 1621–1632. Google Scholar
Ming, D. S., Lopez, A., Hilhouse, B. J., French, C. J., Hudson, J. B. & Towers, G. H. N. (2002). J. Nat. Prod. 65, 1412–1416. Web of Science CrossRef PubMed CAS Google Scholar
Orpen, G., Brammer, L., Allen, F. H., Kennard, O., Watson, D. G. & Taylor, R. (1989). J. Chem. Soc. Dalton Trans. pp. S1–83. CrossRef Web of Science Google Scholar
Sheldrick, G. M. (1996). SADABS. University of Göttingen, Germany. Google Scholar
Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. Web of Science CrossRef CAS IUCr Journals Google Scholar
Van Oeveren, A., Jansen, J. F. G. A. & Feringa, B. L. (1994). J. Org. Chem. 59, 5999–6007. CrossRef CAS Google Scholar

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