organic compounds
Ethyl 6-(4-bromophenyl)-4-(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate
aX-ray Crystallography Laboratory, Post-Graduate Department of Physics & Electronics, University of Jammu, Jammu Tawi 180 006, India, bDepartment of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India, and cDepartment of Chemistry, P.A. College of Engineering, Nadupadavu, Mangalore 574153, India
*Correspondence e-mail: rkvk.paper11@gmail.com
There are two independent molecules in the 21H18BrFO3, in which the dihedral angles between the fluorophenyl and bromophenyl groups are 77.0 (1) and 85.8 (1)°. In one of the molecules, two methine C—H groups of the cyclohexene ring are disordered over two sets of sites in a 0.53 (2):0.47 (2) ratio. In both molecules, the atoms of the ethyl group were refined as disordered over two sets of sites with occupancies of 0.67 (2):0.33 (2) and 0.63 (4):0.37 (4). The cyclohexene rings have slightly distorted sofa conformations in both molecules. In the crystal, C—H⋯O interactions link molecules into chains along the b axis.
of the title compound, CRelated literature
For background to the synthesis, see: Sreevidya et al. (2010); Padmavathi et al. (2000); Senguttuvan & Nagarajan (2010); Butcher et al. (2011). For related structures, see: Dutkiewicz et al. (2011a,b,c); Fun et al. (2010); Harrison et al. (2010). For ring conformations, see: Duax & Norton (1975).
Experimental
Crystal data
|
Refinement
|
Data collection: CrysAlis PRO (Oxford Diffraction, 2010); cell CrysAlis PRO; data reduction: CrysAlis PRO; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: PLATON (Spek, 2009).
Supporting information
https://doi.org/10.1107/S1600536812038202/gk2518sup1.cif
contains datablocks I, global. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536812038202/gk2518Isup2.hkl
Supporting information file. DOI: https://doi.org/10.1107/S1600536812038202/gk2518Isup3.cml
(2E)-3-(4-Bromophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (3.05 g, 0.01 mol) and ethyl acetoacetate (1.30 g, 0.01 mol) were refluxed for 8 h in 30 ml absolute alcohol in presence of 10% NaOH. The reaction mixture was cooled to room temperature and the precipitate obtained was filtered. Single crystals were grown by slow evaporation from absolute alcohol (m.p.= 403 K).
All H atoms were positioned geometrically and were treated as riding on their parent C atoms, with C—H distances of 0.93–0.98 Å and with Uiso(H) = 1.2Ueq(C) or 1.5Ueq(methyl C). Iin the
process restraints were imposed on C-C [1.52 (1) Å] and C-O [1.42 (1) Å] distances of the disordered molecular fragments.Michael addition of ethyl acetoacetate to
yields 4,6-diaryl-2-oxo -cyclohex-3-ene-1-carboxylate derivatives (Sreevidya et al., 2010), which could be used as efficient synthons for building or as intermediates in the synthesis of isoxazoles, pyrazoles and quinazolines (Padmavathi et al., 2000; Senguttuvan & Nagarajan,2010; Butcher et al., 2011). The of some cyclohexenone derivatives, viz., methyl 4,6-bis(4-fluorophenyl)-2-oxo cyclohex-3-ene-1-carboxylate (Fun et al., 2010), (1RS,6SR)-ethyl 4-(4-chlorophenyl)-6-(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate toluene hemisolvate (Dutkiewicz et al., 2011a), (1RS,6SR)-ethyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3]-ene-1-carboxylate (Dutkiewicz et al., 2011b), (1RS,6SR)-ethyl 4-(2,4-dichlorophenyl)-6-(4-fluorophenyl) -2-oxocyclohex-3-ene-1-carboxylate (Dutkiewicz et al.,2011c) and ethyl 4-(2,4-dichlorophenyl)-6-(6-methoxy-2-naphthyl)-2-oxocyclohex-3-ene-1- carboxylate(Harrison et al., 2010) have been reported. In view of the importance of cyclohexenone derivatives, the title compound (I) was prepared and its is reported.In (I) (Fig. 1), all bond lengths and angles are normal and correspond to those to those observed in the related structures (Dutkiewicz et al., 2011a,b,c; Fun et al., 2010; Harrison et al., 2010). The cyclohexene rings have slightly distorted sofa conformations in both the molecules [asymmetry parameters: ΔCs(C3A—C6A) = 4.11 for molecule A; ΔCs(C2B—C5B) = 4.58 /4.65 for molecule B (Duax & Norton, 1975)]. The fluorophenyl and bromophenyl rings are inclined to each other forming dihedral angles of 77.0 (1)° in molecule A and 85.8 (1)° in molecule B. In molecule B, C1 and C6 are disordered over two sites with a 0.53 (2):0.47 (2) ratio. The atoms of the ethyl group were refined as disordered over two sets of sites with occupancies of 0.67 (2)/0.33 (2) and 0.63 (4)/0.37 (4). In the
C—H···O hydrogen bonds create chains of molecules along the y direction (Table 1, Fig. 2).For background to the synthesis, see: Sreevidya et al. (2010); Padmavathi et al. (2000); Senguttuvan & Nagarajan (2010); Butcher et al. (2011). For related structures, see: Dutkiewicz et al. (2011a,b,c); Fun et al. (2010); Harrison et al. (2010). For ring conformations, see: Duax & Norton (1975).
Data collection: CrysAlis PRO (Oxford Diffraction, 2010); cell
CrysAlis PRO (Oxford Diffraction, 2010); data reduction: CrysAlis PRO (Oxford Diffraction, 2010); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: PLATON (Spek, 2009).C21H18BrFO3 | Z = 4 |
Mr = 417.26 | F(000) = 848 |
Triclinic, P1 | Dx = 1.455 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.71073 Å |
a = 11.8886 (5) Å | Cell parameters from 7575 reflections |
b = 13.3481 (5) Å | θ = 3.4–29.0° |
c = 13.4128 (5) Å | µ = 2.19 mm−1 |
α = 77.214 (3)° | T = 293 K |
β = 66.757 (4)° | Block, colourless |
γ = 87.856 (3)° | 0.3 × 0.2 × 0.2 mm |
V = 1904.27 (13) Å3 |
Oxford Diffraction Xcalibur Sapphire3 diffractometer | 7484 independent reflections |
Radiation source: fine-focus sealed tube | 4086 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.049 |
Detector resolution: 16.1049 pixels mm-1 | θmax = 26.0°, θmin = 3.4° |
ω scans | h = −14→14 |
Absorption correction: multi-scan (CrysAlis PRO; Oxford Diffraction, 2010) | k = −16→16 |
Tmin = 0.816, Tmax = 1.000 | l = −16→16 |
27878 measured reflections |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.054 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.139 | H-atom parameters constrained |
S = 1.02 | w = 1/[σ2(Fo2) + (0.0428P)2 + 0.8556P] where P = (Fo2 + 2Fc2)/3 |
7484 reflections | (Δ/σ)max = 0.002 |
526 parameters | Δρmax = 0.49 e Å−3 |
8 restraints | Δρmin = −0.52 e Å−3 |
C21H18BrFO3 | γ = 87.856 (3)° |
Mr = 417.26 | V = 1904.27 (13) Å3 |
Triclinic, P1 | Z = 4 |
a = 11.8886 (5) Å | Mo Kα radiation |
b = 13.3481 (5) Å | µ = 2.19 mm−1 |
c = 13.4128 (5) Å | T = 293 K |
α = 77.214 (3)° | 0.3 × 0.2 × 0.2 mm |
β = 66.757 (4)° |
Oxford Diffraction Xcalibur Sapphire3 diffractometer | 7484 independent reflections |
Absorption correction: multi-scan (CrysAlis PRO; Oxford Diffraction, 2010) | 4086 reflections with I > 2σ(I) |
Tmin = 0.816, Tmax = 1.000 | Rint = 0.049 |
27878 measured reflections |
R[F2 > 2σ(F2)] = 0.054 | 8 restraints |
wR(F2) = 0.139 | H-atom parameters constrained |
S = 1.02 | Δρmax = 0.49 e Å−3 |
7484 reflections | Δρmin = −0.52 e Å−3 |
526 parameters |
Experimental. CrysAlis PRO, Oxford Diffraction Ltd., Version 1.171.34.40 (release 27–08-2010 CrysAlis171. NET) (compiled Aug 27 2010,11:50:40) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
Br1 | 0.77287 (6) | −0.17028 (4) | 0.44941 (5) | 0.1056 (2) | |
Br2 | 0.75908 (7) | 0.51689 (5) | 0.54046 (6) | 0.1305 (3) | |
F1 | 0.3550 (3) | 0.2225 (2) | −0.2653 (2) | 0.1048 (10) | |
F2 | 1.0871 (3) | 0.6057 (2) | 1.3044 (3) | 0.1287 (12) | |
O1A | 0.7343 (3) | 0.4848 (2) | 0.0562 (3) | 0.0910 (10) | |
O2A | 0.8428 (3) | 0.3445 (3) | 0.2372 (3) | 0.1018 (12) | |
O3A | 0.6423 (3) | 0.3555 (3) | 0.2950 (3) | 0.0949 (11) | |
C1A | 0.7418 (3) | 0.3066 (3) | 0.1261 (3) | 0.0520 (9) | |
H1A | 0.8232 | 0.2872 | 0.0806 | 0.062* | |
C2A | 0.7087 (4) | 0.3978 (3) | 0.0551 (3) | 0.0598 (10) | |
C3A | 0.6499 (3) | 0.3773 (3) | −0.0146 (3) | 0.0577 (10) | |
H3A | 0.6352 | 0.4329 | −0.0626 | 0.069* | |
C4A | 0.6151 (3) | 0.2825 (3) | −0.0142 (3) | 0.0464 (9) | |
C5A | 0.6395 (3) | 0.1900 (3) | 0.0593 (3) | 0.0501 (9) | |
H5A1 | 0.7143 | 0.1612 | 0.0161 | 0.060* | |
H5A2 | 0.5730 | 0.1384 | 0.0844 | 0.060* | |
C6A | 0.6521 (3) | 0.2134 (3) | 0.1607 (3) | 0.0496 (9) | |
H6A | 0.5716 | 0.2326 | 0.2081 | 0.060* | |
C7A | 0.6846 (4) | 0.1189 (3) | 0.2291 (3) | 0.0507 (9) | |
C8A | 0.5945 (4) | 0.0566 (3) | 0.3168 (3) | 0.0676 (12) | |
H8A | 0.5133 | 0.0732 | 0.3343 | 0.081* | |
C9A | 0.6201 (5) | −0.0302 (4) | 0.3803 (4) | 0.0795 (14) | |
H9A | 0.5564 | −0.0724 | 0.4380 | 0.095* | |
C10A | 0.7393 (5) | −0.0543 (3) | 0.3583 (4) | 0.0652 (11) | |
C11A | 0.8305 (4) | 0.0051 (3) | 0.2706 (4) | 0.0759 (13) | |
H11A | 0.9117 | −0.0115 | 0.2534 | 0.091* | |
C12A | 0.8028 (4) | 0.0903 (3) | 0.2068 (4) | 0.0743 (13) | |
H12A | 0.8665 | 0.1299 | 0.1464 | 0.089* | |
C13A | 0.5498 (3) | 0.2674 (3) | −0.0844 (3) | 0.0497 (9) | |
C14A | 0.5490 (4) | 0.1739 (3) | −0.1135 (3) | 0.0630 (11) | |
H14A | 0.5926 | 0.1208 | −0.0908 | 0.076* | |
C15A | 0.4850 (4) | 0.1583 (4) | −0.1752 (4) | 0.0752 (13) | |
H15A | 0.4853 | 0.0956 | −0.1947 | 0.090* | |
C16A | 0.4208 (4) | 0.2374 (4) | −0.2072 (3) | 0.0703 (12) | |
C17A | 0.4188 (4) | 0.3300 (4) | −0.1807 (3) | 0.0704 (12) | |
H17A | 0.3752 | 0.3827 | −0.2039 | 0.084* | |
C18A | 0.4830 (4) | 0.3439 (3) | −0.1188 (3) | 0.0636 (11) | |
H18A | 0.4815 | 0.4068 | −0.0994 | 0.076* | |
C19A | 0.7507 (5) | 0.3369 (3) | 0.2249 (4) | 0.0639 (11) | |
O1B | 0.7894 (3) | 1.0258 (2) | 0.8969 (3) | 0.0813 (9) | |
O2B | 0.6448 (3) | 0.9414 (3) | 0.7664 (3) | 0.1059 (12) | |
O3B | 0.8394 (3) | 0.9849 (3) | 0.6646 (3) | 0.0984 (11) | |
C2B | 0.8113 (4) | 0.9352 (3) | 0.9076 (3) | 0.0615 (11) | |
C3B | 0.8562 (3) | 0.8817 (3) | 0.9891 (3) | 0.0524 (9) | |
H3B | 0.8648 | 0.9176 | 1.0380 | 0.063* | |
C4B | 0.8864 (3) | 0.7835 (3) | 0.9984 (3) | 0.0448 (9) | |
C5B | 0.8690 (3) | 0.7201 (3) | 0.9254 (3) | 0.0483 (9) | |
H5B1 | 0.7959 | 0.6749 | 0.9676 | 0.058* | |
H5B2 | 0.9385 | 0.6776 | 0.9020 | 0.058* | |
C7B | 0.8113 (5) | 0.7136 (3) | 0.7658 (4) | 0.0650 (12) | |
C8B | 0.9083 (5) | 0.6896 (3) | 0.6797 (4) | 0.0730 (13) | |
H8B | 0.9867 | 0.7139 | 0.6652 | 0.088* | |
C9B | 0.8935 (4) | 0.6307 (3) | 0.6137 (4) | 0.0737 (13) | |
H9B | 0.9614 | 0.6145 | 0.5560 | 0.088* | |
C10B | 0.7785 (5) | 0.5958 (3) | 0.6333 (4) | 0.0657 (12) | |
C11B | 0.6797 (4) | 0.6188 (4) | 0.7187 (4) | 0.0741 (12) | |
H11B | 0.6012 | 0.5952 | 0.7322 | 0.089* | |
C12B | 0.6965 (5) | 0.6773 (4) | 0.7847 (4) | 0.0791 (13) | |
H12B | 0.6288 | 0.6924 | 0.8434 | 0.095* | |
C13B | 0.9384 (3) | 0.7348 (3) | 1.0797 (3) | 0.0488 (9) | |
C14B | 0.9309 (4) | 0.6287 (3) | 1.1197 (3) | 0.0649 (11) | |
H14B | 0.8917 | 0.5866 | 1.0951 | 0.078* | |
C15B | 0.9806 (4) | 0.5851 (3) | 1.1950 (4) | 0.0834 (14) | |
H15B | 0.9752 | 0.5142 | 1.2214 | 0.100* | |
C16B | 1.0380 (4) | 0.6482 (4) | 1.2301 (4) | 0.0754 (13) | |
C17B | 1.0500 (4) | 0.7517 (3) | 1.1916 (4) | 0.0723 (12) | |
H17B | 1.0913 | 0.7926 | 1.2155 | 0.087* | |
C18B | 1.0003 (4) | 0.7949 (3) | 1.1171 (3) | 0.0599 (10) | |
H18B | 1.0079 | 0.8659 | 1.0907 | 0.072* | |
C19B | 0.7485 (5) | 0.9349 (3) | 0.7526 (4) | 0.0682 (12) | |
C1B | 0.825 (2) | 0.8778 (8) | 0.8156 (15) | 0.065 (4) | 0.53 (2) |
H1B | 0.9043 | 0.9110 | 0.7622 | 0.078* | 0.53 (2) |
C6B | 0.8566 (13) | 0.7901 (9) | 0.8195 (11) | 0.043 (2) | 0.53 (2) |
H6B | 0.9431 | 0.8023 | 0.7682 | 0.051* | 0.53 (2) |
C1D | 0.7572 (13) | 0.8634 (10) | 0.8570 (11) | 0.041 (3) | 0.47 (2) |
H1D | 0.6712 | 0.8524 | 0.9094 | 0.049* | 0.47 (2) |
C6D | 0.795 (2) | 0.7666 (9) | 0.8617 (14) | 0.051 (4) | 0.47 (2) |
H6D | 0.7165 | 0.7314 | 0.9145 | 0.062* | 0.47 (2) |
C20B | 0.825 (2) | 1.0523 (11) | 0.5699 (10) | 0.139 (6) | 0.670 (17) |
H20C | 0.7481 | 1.0363 | 0.5669 | 0.167* | 0.670 (17) |
H20D | 0.8917 | 1.0455 | 0.5010 | 0.167* | 0.670 (17) |
C21B | 0.8291 (12) | 1.1592 (8) | 0.5877 (12) | 0.133 (6) | 0.670 (17) |
H21A | 0.8139 | 1.2075 | 0.5303 | 0.199* | 0.670 (17) |
H21B | 0.9083 | 1.1755 | 0.5852 | 0.199* | 0.670 (17) |
H21C | 0.7673 | 1.1629 | 0.6591 | 0.199* | 0.670 (17) |
C20D | 0.7758 (19) | 1.053 (2) | 0.608 (2) | 0.110 (10) | 0.330 (17) |
H20E | 0.7269 | 1.0972 | 0.6550 | 0.132* | 0.330 (17) |
H20F | 0.7213 | 1.0127 | 0.5918 | 0.132* | 0.330 (17) |
C21D | 0.868 (2) | 1.117 (3) | 0.501 (2) | 0.160 (12) | 0.330 (17) |
H21D | 0.8261 | 1.1610 | 0.4617 | 0.240* | 0.330 (17) |
H21E | 0.9172 | 1.0723 | 0.4548 | 0.240* | 0.330 (17) |
H21F | 0.9204 | 1.1579 | 0.5173 | 0.240* | 0.330 (17) |
C20A | 0.659 (3) | 0.371 (4) | 0.3923 (19) | 0.098 (9) | 0.37 (4) |
H20A | 0.6931 | 0.4398 | 0.3788 | 0.117* | 0.37 (4) |
H20B | 0.7130 | 0.3215 | 0.4113 | 0.117* | 0.37 (4) |
C21A | 0.533 (3) | 0.355 (5) | 0.484 (3) | 0.126 (14) | 0.37 (4) |
H21G | 0.5354 | 0.3748 | 0.5481 | 0.190* | 0.37 (4) |
H21H | 0.5050 | 0.2844 | 0.5038 | 0.190* | 0.37 (4) |
H21I | 0.4772 | 0.3974 | 0.4595 | 0.190* | 0.37 (4) |
C20C | 0.624 (2) | 0.4003 (15) | 0.3906 (11) | 0.099 (6) | 0.63 (4) |
H20G | 0.5584 | 0.4478 | 0.4021 | 0.119* | 0.63 (4) |
H20H | 0.6982 | 0.4356 | 0.3814 | 0.119* | 0.63 (4) |
C21C | 0.589 (4) | 0.3070 (16) | 0.484 (2) | 0.150 (9) | 0.63 (4) |
H21J | 0.5817 | 0.3264 | 0.5513 | 0.225* | 0.63 (4) |
H21K | 0.6517 | 0.2583 | 0.4668 | 0.225* | 0.63 (4) |
H21L | 0.5125 | 0.2765 | 0.4946 | 0.225* | 0.63 (4) |
U11 | U22 | U33 | U12 | U13 | U23 | |
Br1 | 0.1496 (6) | 0.0713 (4) | 0.1123 (5) | 0.0181 (3) | −0.0823 (4) | 0.0029 (3) |
Br2 | 0.1991 (7) | 0.1141 (5) | 0.1657 (6) | 0.0466 (5) | −0.1374 (6) | −0.0866 (5) |
F1 | 0.112 (2) | 0.141 (3) | 0.105 (2) | 0.0235 (19) | −0.0783 (18) | −0.0513 (19) |
F2 | 0.194 (3) | 0.093 (2) | 0.156 (3) | 0.007 (2) | −0.145 (3) | 0.001 (2) |
O1A | 0.130 (3) | 0.0419 (17) | 0.130 (3) | −0.0011 (18) | −0.080 (2) | −0.0210 (18) |
O2A | 0.089 (2) | 0.124 (3) | 0.137 (3) | 0.021 (2) | −0.074 (2) | −0.064 (2) |
O3A | 0.081 (2) | 0.133 (3) | 0.090 (2) | 0.005 (2) | −0.0300 (19) | −0.070 (2) |
C1A | 0.054 (2) | 0.047 (2) | 0.063 (2) | 0.0052 (18) | −0.0262 (19) | −0.0231 (19) |
C2A | 0.070 (3) | 0.039 (2) | 0.080 (3) | 0.005 (2) | −0.036 (2) | −0.019 (2) |
C3A | 0.071 (3) | 0.039 (2) | 0.071 (3) | 0.0051 (19) | −0.039 (2) | −0.0081 (19) |
C4A | 0.048 (2) | 0.045 (2) | 0.046 (2) | 0.0056 (17) | −0.0174 (17) | −0.0124 (17) |
C5A | 0.061 (2) | 0.043 (2) | 0.056 (2) | 0.0043 (18) | −0.0306 (19) | −0.0149 (18) |
C6A | 0.057 (2) | 0.045 (2) | 0.055 (2) | 0.0024 (18) | −0.0284 (19) | −0.0141 (18) |
C7A | 0.061 (3) | 0.047 (2) | 0.056 (2) | 0.0033 (19) | −0.034 (2) | −0.0153 (19) |
C8A | 0.057 (3) | 0.059 (3) | 0.074 (3) | −0.001 (2) | −0.022 (2) | 0.002 (2) |
C9A | 0.085 (3) | 0.065 (3) | 0.074 (3) | −0.005 (3) | −0.027 (3) | 0.008 (2) |
C10A | 0.088 (3) | 0.049 (2) | 0.073 (3) | 0.006 (2) | −0.052 (3) | −0.008 (2) |
C11A | 0.066 (3) | 0.068 (3) | 0.095 (3) | 0.008 (2) | −0.042 (3) | −0.002 (3) |
C12A | 0.064 (3) | 0.065 (3) | 0.079 (3) | 0.000 (2) | −0.026 (2) | 0.008 (2) |
C13A | 0.056 (2) | 0.052 (2) | 0.046 (2) | 0.0076 (19) | −0.0226 (19) | −0.0148 (18) |
C14A | 0.070 (3) | 0.065 (3) | 0.073 (3) | 0.020 (2) | −0.041 (2) | −0.030 (2) |
C15A | 0.084 (3) | 0.084 (3) | 0.086 (3) | 0.019 (3) | −0.049 (3) | −0.048 (3) |
C16A | 0.069 (3) | 0.100 (4) | 0.057 (3) | 0.011 (3) | −0.035 (2) | −0.030 (3) |
C17A | 0.080 (3) | 0.078 (3) | 0.064 (3) | 0.021 (3) | −0.043 (2) | −0.012 (2) |
C18A | 0.073 (3) | 0.056 (3) | 0.070 (3) | 0.009 (2) | −0.038 (2) | −0.012 (2) |
C19A | 0.072 (3) | 0.054 (3) | 0.084 (3) | 0.008 (2) | −0.045 (3) | −0.026 (2) |
O1B | 0.122 (3) | 0.0407 (17) | 0.115 (2) | 0.0241 (16) | −0.077 (2) | −0.0292 (17) |
O2B | 0.089 (3) | 0.113 (3) | 0.129 (3) | 0.000 (2) | −0.058 (2) | −0.027 (2) |
O3B | 0.100 (3) | 0.097 (3) | 0.095 (3) | −0.004 (2) | −0.040 (2) | −0.012 (2) |
C2B | 0.081 (3) | 0.040 (2) | 0.077 (3) | 0.007 (2) | −0.043 (2) | −0.018 (2) |
C3B | 0.062 (2) | 0.044 (2) | 0.062 (2) | 0.0060 (18) | −0.031 (2) | −0.0206 (19) |
C4B | 0.043 (2) | 0.040 (2) | 0.054 (2) | 0.0004 (16) | −0.0208 (17) | −0.0122 (17) |
C5B | 0.054 (2) | 0.038 (2) | 0.062 (2) | 0.0081 (17) | −0.0297 (19) | −0.0156 (18) |
C7B | 0.106 (4) | 0.043 (2) | 0.076 (3) | 0.023 (2) | −0.063 (3) | −0.024 (2) |
C8B | 0.083 (3) | 0.059 (3) | 0.098 (4) | 0.006 (2) | −0.055 (3) | −0.022 (3) |
C9B | 0.083 (3) | 0.076 (3) | 0.075 (3) | 0.020 (3) | −0.038 (3) | −0.033 (3) |
C10B | 0.099 (4) | 0.049 (2) | 0.081 (3) | 0.021 (2) | −0.065 (3) | −0.025 (2) |
C11B | 0.078 (3) | 0.071 (3) | 0.085 (3) | 0.005 (3) | −0.043 (3) | −0.020 (3) |
C12B | 0.097 (4) | 0.083 (3) | 0.069 (3) | 0.021 (3) | −0.037 (3) | −0.034 (3) |
C13B | 0.054 (2) | 0.046 (2) | 0.051 (2) | 0.0056 (18) | −0.0234 (19) | −0.0145 (18) |
C14B | 0.079 (3) | 0.048 (2) | 0.084 (3) | −0.001 (2) | −0.052 (2) | −0.010 (2) |
C15B | 0.113 (4) | 0.052 (3) | 0.104 (4) | −0.002 (3) | −0.073 (3) | 0.001 (3) |
C16B | 0.099 (3) | 0.063 (3) | 0.087 (3) | 0.004 (3) | −0.066 (3) | −0.005 (3) |
C17B | 0.096 (3) | 0.061 (3) | 0.083 (3) | 0.001 (2) | −0.057 (3) | −0.019 (2) |
C18B | 0.079 (3) | 0.047 (2) | 0.066 (3) | 0.004 (2) | −0.041 (2) | −0.013 (2) |
C19B | 0.094 (4) | 0.047 (3) | 0.088 (4) | 0.012 (3) | −0.062 (3) | −0.017 (2) |
C1B | 0.099 (12) | 0.029 (5) | 0.085 (9) | −0.008 (6) | −0.060 (9) | −0.002 (5) |
C6B | 0.053 (6) | 0.028 (5) | 0.041 (6) | −0.012 (5) | −0.017 (5) | 0.001 (4) |
C1D | 0.026 (5) | 0.040 (6) | 0.055 (7) | −0.002 (5) | −0.014 (5) | −0.009 (5) |
C6D | 0.086 (11) | 0.021 (5) | 0.052 (8) | −0.012 (6) | −0.037 (8) | 0.005 (5) |
C20B | 0.209 (18) | 0.122 (11) | 0.044 (10) | −0.031 (11) | −0.027 (11) | 0.030 (8) |
C21B | 0.167 (10) | 0.097 (9) | 0.124 (12) | −0.018 (7) | −0.067 (9) | 0.017 (7) |
C20D | 0.16 (2) | 0.113 (19) | 0.023 (12) | −0.050 (15) | −0.022 (15) | 0.026 (10) |
C21D | 0.18 (2) | 0.19 (3) | 0.077 (17) | −0.01 (2) | −0.029 (15) | −0.006 (19) |
C20A | 0.13 (2) | 0.095 (19) | 0.096 (18) | 0.045 (14) | −0.056 (13) | −0.068 (15) |
C21A | 0.097 (19) | 0.20 (5) | 0.075 (15) | −0.010 (16) | −0.015 (13) | −0.06 (2) |
C20C | 0.100 (13) | 0.122 (16) | 0.093 (10) | −0.001 (9) | −0.036 (10) | −0.064 (8) |
C21C | 0.18 (3) | 0.17 (2) | 0.102 (11) | −0.035 (14) | −0.048 (16) | −0.025 (12) |
Br1—C10A | 1.884 (4) | C5B—H5B1 | 0.9700 |
Br2—C10B | 1.881 (4) | C5B—H5B2 | 0.9700 |
F1—C16A | 1.349 (4) | C7B—C8B | 1.360 (6) |
F2—C16B | 1.356 (4) | C7B—C12B | 1.373 (6) |
O1A—C2A | 1.217 (4) | C7B—C6D | 1.547 (13) |
O2A—C19A | 1.181 (5) | C7B—C6B | 1.589 (11) |
O3A—C19A | 1.315 (5) | C8B—C9B | 1.368 (6) |
O3A—C20A | 1.451 (10) | C8B—H8B | 0.9300 |
O3A—C20C | 1.469 (8) | C9B—C10B | 1.366 (6) |
C1A—C19A | 1.512 (5) | C9B—H9B | 0.9300 |
C1A—C2A | 1.513 (5) | C10B—C11B | 1.361 (6) |
C1A—C6A | 1.534 (5) | C11B—C12B | 1.375 (6) |
C1A—H1A | 0.9800 | C11B—H11B | 0.9300 |
C2A—C3A | 1.442 (5) | C12B—H12B | 0.9300 |
C3A—C4A | 1.344 (5) | C13B—C14B | 1.392 (5) |
C3A—H3A | 0.9300 | C13B—C18B | 1.397 (5) |
C4A—C13A | 1.484 (5) | C14B—C15B | 1.376 (5) |
C4A—C5A | 1.498 (5) | C14B—H14B | 0.9300 |
C5A—C6A | 1.523 (5) | C15B—C16B | 1.366 (6) |
C5A—H5A1 | 0.9700 | C15B—H15B | 0.9300 |
C5A—H5A2 | 0.9700 | C16B—C17B | 1.356 (6) |
C6A—C7A | 1.520 (5) | C17B—C18B | 1.365 (5) |
C6A—H6A | 0.9800 | C17B—H17B | 0.9300 |
C7A—C8A | 1.365 (5) | C18B—H18B | 0.9300 |
C7A—C12A | 1.375 (5) | C19B—C1B | 1.544 (13) |
C8A—C9A | 1.379 (5) | C19B—C1D | 1.548 (13) |
C8A—H8A | 0.9300 | C1B—C6B | 1.213 (16) |
C9A—C10A | 1.370 (6) | C1B—H1B | 0.9800 |
C9A—H9A | 0.9300 | C6B—H6B | 0.9800 |
C10A—C11A | 1.355 (6) | C1D—C6D | 1.350 (15) |
C11A—C12A | 1.377 (5) | C1D—H1D | 0.9800 |
C11A—H11A | 0.9300 | C6D—H6D | 0.9800 |
C12A—H12A | 0.9300 | C20B—C21B | 1.502 (10) |
C13A—C18A | 1.380 (5) | C20B—H20C | 0.9700 |
C13A—C14A | 1.389 (5) | C20B—H20D | 0.9700 |
C14A—C15A | 1.375 (5) | C21B—H21A | 0.9600 |
C14A—H14A | 0.9300 | C21B—H21B | 0.9600 |
C15A—C16A | 1.372 (6) | C21B—H21C | 0.9600 |
C15A—H15A | 0.9300 | C20D—C21D | 1.514 (10) |
C16A—C17A | 1.356 (6) | C20D—H20E | 0.9700 |
C17A—C18A | 1.373 (5) | C20D—H20F | 0.9700 |
C17A—H17A | 0.9300 | C21D—H21D | 0.9600 |
C18A—H18A | 0.9300 | C21D—H21E | 0.9600 |
O1B—C2B | 1.216 (4) | C21D—H21F | 0.9600 |
O2B—C19B | 1.176 (5) | C20A—C21A | 1.503 (10) |
O3B—C19B | 1.306 (6) | C20A—H20A | 0.9700 |
O3B—C20D | 1.437 (10) | C20A—H20B | 0.9700 |
O3B—C20B | 1.449 (8) | C21A—H21G | 0.9600 |
C2B—C3B | 1.442 (5) | C21A—H21H | 0.9600 |
C2B—C1B | 1.546 (14) | C21A—H21I | 0.9600 |
C2B—C1D | 1.571 (13) | C20C—C21C | 1.495 (10) |
C3B—C4B | 1.338 (5) | C20C—H20G | 0.9700 |
C3B—H3B | 0.9300 | C20C—H20H | 0.9700 |
C4B—C13B | 1.476 (5) | C21C—H21J | 0.9600 |
C4B—C5B | 1.503 (5) | C21C—H21K | 0.9600 |
C5B—C6D | 1.482 (13) | C21C—H21L | 0.9600 |
C5B—C6B | 1.574 (12) | ||
C19A—O3A—C20A | 106.5 (12) | C9B—C10B—Br2 | 119.2 (4) |
C19A—O3A—C20C | 123.6 (11) | C10B—C11B—C12B | 119.6 (4) |
C19A—C1A—C2A | 110.1 (3) | C10B—C11B—H11B | 120.2 |
C19A—C1A—C6A | 112.4 (3) | C12B—C11B—H11B | 120.2 |
C2A—C1A—C6A | 111.5 (3) | C7B—C12B—C11B | 121.2 (4) |
C19A—C1A—H1A | 107.5 | C7B—C12B—H12B | 119.4 |
C2A—C1A—H1A | 107.5 | C11B—C12B—H12B | 119.4 |
C6A—C1A—H1A | 107.5 | C14B—C13B—C18B | 117.5 (3) |
O1A—C2A—C3A | 122.2 (4) | C14B—C13B—C4B | 122.2 (3) |
O1A—C2A—C1A | 120.0 (4) | C18B—C13B—C4B | 120.4 (3) |
C3A—C2A—C1A | 117.8 (3) | C15B—C14B—C13B | 121.1 (4) |
C4A—C3A—C2A | 123.9 (4) | C15B—C14B—H14B | 119.5 |
C4A—C3A—H3A | 118.1 | C13B—C14B—H14B | 119.5 |
C2A—C3A—H3A | 118.1 | C16B—C15B—C14B | 118.7 (4) |
C3A—C4A—C13A | 121.0 (3) | C16B—C15B—H15B | 120.7 |
C3A—C4A—C5A | 120.3 (3) | C14B—C15B—H15B | 120.7 |
C13A—C4A—C5A | 118.7 (3) | C17B—C16B—F2 | 118.6 (4) |
C4A—C5A—C6A | 113.4 (3) | C17B—C16B—C15B | 122.4 (4) |
C4A—C5A—H5A1 | 108.9 | F2—C16B—C15B | 119.0 (4) |
C6A—C5A—H5A1 | 108.9 | C16B—C17B—C18B | 118.9 (4) |
C4A—C5A—H5A2 | 108.9 | C16B—C17B—H17B | 120.6 |
C6A—C5A—H5A2 | 108.9 | C18B—C17B—H17B | 120.6 |
H5A1—C5A—H5A2 | 107.7 | C17B—C18B—C13B | 121.5 (4) |
C7A—C6A—C5A | 111.7 (3) | C17B—C18B—H18B | 119.2 |
C7A—C6A—C1A | 113.2 (3) | C13B—C18B—H18B | 119.2 |
C5A—C6A—C1A | 110.7 (3) | O2B—C19B—O3B | 124.2 (4) |
C7A—C6A—H6A | 107.0 | O2B—C19B—C1B | 138.0 (10) |
C5A—C6A—H6A | 107.0 | O3B—C19B—C1B | 97.8 (9) |
C1A—C6A—H6A | 107.0 | O2B—C19B—C1D | 109.0 (7) |
C8A—C7A—C12A | 116.4 (4) | O3B—C19B—C1D | 126.7 (7) |
C8A—C7A—C6A | 120.3 (4) | C6B—C1B—C19B | 127.8 (9) |
C12A—C7A—C6A | 123.3 (4) | C6B—C1B—C2B | 122.4 (9) |
C7A—C8A—C9A | 122.1 (4) | C19B—C1B—C2B | 106.2 (10) |
C7A—C8A—H8A | 119.0 | C6B—C1B—H1B | 96.3 |
C9A—C8A—H8A | 119.0 | C19B—C1B—H1B | 96.3 |
C10A—C9A—C8A | 120.0 (4) | C2B—C1B—H1B | 96.3 |
C10A—C9A—H9A | 120.0 | C1B—C6B—C5B | 123.0 (9) |
C8A—C9A—H9A | 120.0 | C1B—C6B—C7B | 121.9 (9) |
C11A—C10A—C9A | 119.2 (4) | C5B—C6B—C7B | 105.1 (8) |
C11A—C10A—Br1 | 121.4 (4) | C1B—C6B—H6B | 100.5 |
C9A—C10A—Br1 | 119.4 (3) | C5B—C6B—H6B | 100.5 |
C10A—C11A—C12A | 119.8 (4) | C7B—C6B—H6B | 100.5 |
C10A—C11A—H11A | 120.1 | C6D—C1D—C19B | 124.6 (10) |
C12A—C11A—H11A | 120.1 | C6D—C1D—C2B | 117.0 (9) |
C7A—C12A—C11A | 122.4 (4) | C19B—C1D—C2B | 104.7 (9) |
C7A—C12A—H12A | 118.8 | C6D—C1D—H1D | 102.4 |
C11A—C12A—H12A | 118.8 | C19B—C1D—H1D | 102.4 |
C18A—C13A—C14A | 117.5 (3) | C2B—C1D—H1D | 102.4 |
C18A—C13A—C4A | 121.3 (4) | C1D—C6D—C5B | 124.0 (9) |
C14A—C13A—C4A | 121.1 (3) | C1D—C6D—C7B | 119.6 (9) |
C15A—C14A—C13A | 121.3 (4) | C5B—C6D—C7B | 112.0 (10) |
C15A—C14A—H14A | 119.4 | C1D—C6D—H6D | 97.0 |
C13A—C14A—H14A | 119.4 | C5B—C6D—H6D | 97.0 |
C16A—C15A—C14A | 118.4 (4) | C7B—C6D—H6D | 97.0 |
C16A—C15A—H15A | 120.8 | O3B—C20B—C21B | 105.3 (9) |
C14A—C15A—H15A | 120.8 | O3B—C20B—H20C | 110.7 |
F1—C16A—C17A | 118.5 (4) | C21B—C20B—H20C | 110.7 |
F1—C16A—C15A | 119.1 (4) | O3B—C20B—H20D | 110.7 |
C17A—C16A—C15A | 122.4 (4) | C21B—C20B—H20D | 110.7 |
C16A—C17A—C18A | 118.3 (4) | H20C—C20B—H20D | 108.8 |
C16A—C17A—H17A | 120.9 | C20B—C21B—H21A | 109.5 |
C18A—C17A—H17A | 120.9 | C20B—C21B—H21B | 109.5 |
C17A—C18A—C13A | 122.1 (4) | H21A—C21B—H21B | 109.5 |
C17A—C18A—H18A | 119.0 | C20B—C21B—H21C | 109.5 |
C13A—C18A—H18A | 119.0 | H21A—C21B—H21C | 109.5 |
O2A—C19A—O3A | 124.3 (4) | H21B—C21B—H21C | 109.5 |
O2A—C19A—C1A | 124.7 (5) | O3B—C20D—C21D | 109.3 (18) |
O3A—C19A—C1A | 111.0 (4) | O3B—C20D—H20E | 109.8 |
C19B—O3B—C20D | 101.7 (9) | C21D—C20D—H20E | 109.8 |
C19B—O3B—C20B | 124.3 (10) | O3B—C20D—H20F | 109.8 |
O1B—C2B—C3B | 122.9 (4) | C21D—C20D—H20F | 109.8 |
O1B—C2B—C1B | 120.9 (5) | H20E—C20D—H20F | 108.3 |
C3B—C2B—C1B | 114.3 (5) | C20D—C21D—H21D | 109.5 |
O1B—C2B—C1D | 120.2 (5) | C20D—C21D—H21E | 109.5 |
C3B—C2B—C1D | 114.8 (5) | H21D—C21D—H21E | 109.5 |
C4B—C3B—C2B | 123.8 (3) | C20D—C21D—H21F | 109.5 |
C4B—C3B—H3B | 118.1 | H21D—C21D—H21F | 109.5 |
C2B—C3B—H3B | 118.1 | H21E—C21D—H21F | 109.5 |
C3B—C4B—C13B | 121.1 (3) | O3A—C20A—C21A | 105 (2) |
C3B—C4B—C5B | 120.6 (3) | O3A—C20A—H20A | 110.6 |
C13B—C4B—C5B | 118.3 (3) | C21A—C20A—H20A | 110.6 |
C6D—C5B—C4B | 115.2 (5) | O3A—C20A—H20B | 110.6 |
C4B—C5B—C6B | 111.5 (5) | C21A—C20A—H20B | 110.6 |
C6D—C5B—H5B1 | 82.3 | H20A—C20A—H20B | 108.8 |
C4B—C5B—H5B1 | 109.3 | C20A—C21A—H21G | 109.5 |
C6B—C5B—H5B1 | 109.3 | C20A—C21A—H21H | 109.5 |
C6D—C5B—H5B2 | 127.5 | H21G—C21A—H21H | 109.5 |
C4B—C5B—H5B2 | 109.3 | C20A—C21A—H21I | 109.5 |
C6B—C5B—H5B2 | 109.3 | H21G—C21A—H21I | 109.5 |
H5B1—C5B—H5B2 | 108.0 | H21H—C21A—H21I | 109.5 |
C8B—C7B—C12B | 117.9 (4) | O3A—C20C—C21C | 101.9 (15) |
C8B—C7B—C6D | 135.5 (9) | O3A—C20C—H20G | 111.4 |
C12B—C7B—C6D | 106.4 (9) | C21C—C20C—H20G | 111.4 |
C8B—C7B—C6B | 109.8 (7) | O3A—C20C—H20H | 111.4 |
C12B—C7B—C6B | 132.1 (7) | C21C—C20C—H20H | 111.4 |
C7B—C8B—C9B | 121.8 (4) | H20G—C20C—H20H | 109.3 |
C7B—C8B—H8B | 119.1 | C20C—C21C—H21J | 109.5 |
C9B—C8B—H8B | 119.1 | C20C—C21C—H21K | 109.5 |
C10B—C9B—C8B | 119.5 (4) | H21J—C21C—H21K | 109.5 |
C10B—C9B—H9B | 120.2 | C20C—C21C—H21L | 109.5 |
C8B—C9B—H9B | 120.2 | H21J—C21C—H21L | 109.5 |
C11B—C10B—C9B | 120.0 (4) | H21K—C21C—H21L | 109.5 |
C11B—C10B—Br2 | 120.9 (4) | ||
C19A—C1A—C2A—O1A | 25.6 (6) | C18B—C13B—C14B—C15B | 1.3 (6) |
C6A—C1A—C2A—O1A | 151.1 (4) | C4B—C13B—C14B—C15B | 179.7 (4) |
C19A—C1A—C2A—C3A | −156.1 (4) | C13B—C14B—C15B—C16B | −0.1 (7) |
C6A—C1A—C2A—C3A | −30.5 (5) | C14B—C15B—C16B—C17B | −1.5 (8) |
O1A—C2A—C3A—C4A | −176.8 (4) | C14B—C15B—C16B—F2 | 180.0 (4) |
C1A—C2A—C3A—C4A | 4.9 (6) | F2—C16B—C17B—C18B | −179.8 (4) |
C2A—C3A—C4A—C13A | 177.2 (3) | C15B—C16B—C17B—C18B | 1.7 (8) |
C2A—C3A—C4A—C5A | −1.6 (6) | C16B—C17B—C18B—C13B | −0.3 (7) |
C3A—C4A—C5A—C6A | 24.7 (5) | C14B—C13B—C18B—C17B | −1.1 (6) |
C13A—C4A—C5A—C6A | −154.1 (3) | C4B—C13B—C18B—C17B | −179.5 (4) |
C4A—C5A—C6A—C7A | −176.5 (3) | C20D—O3B—C19B—O2B | 7.7 (17) |
C4A—C5A—C6A—C1A | −49.5 (4) | C20B—O3B—C19B—O2B | −2.4 (10) |
C19A—C1A—C6A—C7A | −57.6 (4) | C20D—O3B—C19B—C1B | −171.8 (17) |
C2A—C1A—C6A—C7A | 178.2 (3) | C20B—O3B—C19B—C1B | 178.1 (9) |
C19A—C1A—C6A—C5A | 176.2 (3) | C20D—O3B—C19B—C1D | −168.8 (17) |
C2A—C1A—C6A—C5A | 52.0 (4) | C20B—O3B—C19B—C1D | −178.9 (9) |
C5A—C6A—C7A—C8A | −93.4 (4) | O2B—C19B—C1B—C6B | 82 (2) |
C1A—C6A—C7A—C8A | 141.0 (4) | O3B—C19B—C1B—C6B | −98.4 (16) |
C5A—C6A—C7A—C12A | 85.6 (5) | C1D—C19B—C1B—C6B | 86.5 (17) |
C1A—C6A—C7A—C12A | −40.0 (5) | O2B—C19B—C1B—C2B | −76.4 (12) |
C12A—C7A—C8A—C9A | 0.3 (6) | O3B—C19B—C1B—C2B | 103.0 (11) |
C6A—C7A—C8A—C9A | 179.4 (4) | C1D—C19B—C1B—C2B | −72 (2) |
C7A—C8A—C9A—C10A | 2.1 (7) | O1B—C2B—C1B—C6B | 173.6 (10) |
C8A—C9A—C10A—C11A | −3.2 (7) | C3B—C2B—C1B—C6B | 8.5 (18) |
C8A—C9A—C10A—Br1 | 177.6 (3) | C1D—C2B—C1B—C6B | −89.1 (16) |
C9A—C10A—C11A—C12A | 1.8 (7) | O1B—C2B—C1B—C19B | −26.3 (16) |
Br1—C10A—C11A—C12A | −178.9 (4) | C3B—C2B—C1B—C19B | 168.5 (8) |
C8A—C7A—C12A—C11A | −1.7 (7) | C1D—C2B—C1B—C19B | 71 (2) |
C6A—C7A—C12A—C11A | 179.2 (4) | C19B—C1B—C6B—C5B | −146.3 (18) |
C10A—C11A—C12A—C7A | 0.7 (7) | C2B—C1B—C6B—C5B | 9.1 (18) |
C3A—C4A—C13A—C18A | −24.5 (5) | C19B—C1B—C6B—C7B | −6 (2) |
C5A—C4A—C13A—C18A | 154.3 (4) | C2B—C1B—C6B—C7B | 149.5 (16) |
C3A—C4A—C13A—C14A | 158.6 (4) | C6D—C5B—C6B—C1B | 81.1 (17) |
C5A—C4A—C13A—C14A | −22.6 (5) | C4B—C5B—C6B—C1B | −22.5 (12) |
C18A—C13A—C14A—C15A | 0.6 (6) | C6D—C5B—C6B—C7B | −64.7 (15) |
C4A—C13A—C14A—C15A | 177.6 (4) | C4B—C5B—C6B—C7B | −168.4 (5) |
C13A—C14A—C15A—C16A | −0.4 (7) | C8B—C7B—C6B—C1B | 114.5 (11) |
C14A—C15A—C16A—F1 | −178.3 (4) | C12B—C7B—C6B—C1B | −59.3 (13) |
C14A—C15A—C16A—C17A | 0.3 (7) | C6D—C7B—C6B—C1B | −84.3 (18) |
F1—C16A—C17A—C18A | 178.1 (4) | C8B—C7B—C6B—C5B | −99.1 (8) |
C15A—C16A—C17A—C18A | −0.5 (7) | C12B—C7B—C6B—C5B | 87.0 (8) |
C16A—C17A—C18A—C13A | 0.8 (6) | C6D—C7B—C6B—C5B | 62.0 (15) |
C14A—C13A—C18A—C17A | −0.8 (6) | O2B—C19B—C1D—C6D | 106.5 (10) |
C4A—C13A—C18A—C17A | −177.8 (4) | O3B—C19B—C1D—C6D | −76.5 (12) |
C20A—O3A—C19A—O2A | −8 (2) | C1B—C19B—C1D—C6D | −70.4 (15) |
C20C—O3A—C19A—O2A | 7.8 (12) | O2B—C19B—C1D—C2B | −114.7 (7) |
C20A—O3A—C19A—C1A | 173.0 (19) | O3B—C19B—C1D—C2B | 62.3 (9) |
C20C—O3A—C19A—C1A | −171.1 (10) | C1B—C19B—C1D—C2B | 68.4 (16) |
C2A—C1A—C19A—O2A | −110.4 (5) | O1B—C2B—C1D—C6D | 173.3 (9) |
C6A—C1A—C19A—O2A | 124.6 (5) | C3B—C2B—C1D—C6D | −22.7 (11) |
C2A—C1A—C19A—O3A | 68.6 (4) | C1B—C2B—C1D—C6D | 73.2 (15) |
C6A—C1A—C19A—O3A | −56.4 (5) | O1B—C2B—C1D—C19B | 30.8 (10) |
O1B—C2B—C3B—C4B | −176.6 (4) | C3B—C2B—C1D—C19B | −165.3 (5) |
C1B—C2B—C3B—C4B | −11.8 (11) | C1B—C2B—C1D—C19B | −69.4 (16) |
C1D—C2B—C3B—C4B | 19.9 (8) | C19B—C1D—C6D—C5B | 143.6 (17) |
C2B—C3B—C4B—C13B | 176.6 (3) | C2B—C1D—C6D—C5B | 9.3 (18) |
C2B—C3B—C4B—C5B | −2.9 (6) | C19B—C1D—C6D—C7B | −10.9 (17) |
C3B—C4B—C5B—C6D | −11.8 (11) | C2B—C1D—C6D—C7B | −145.3 (15) |
C13B—C4B—C5B—C6D | 168.8 (10) | C4B—C5B—C6D—C1D | 7.8 (18) |
C3B—C4B—C5B—C6B | 18.8 (7) | C6B—C5B—C6D—C1D | −81.0 (16) |
C13B—C4B—C5B—C6B | −160.7 (6) | C4B—C5B—C6D—C7B | 164.0 (8) |
C12B—C7B—C8B—C9B | −0.4 (6) | C6B—C5B—C6D—C7B | 75 (2) |
C6D—C7B—C8B—C9B | 172.3 (7) | C8B—C7B—C6D—C1D | 105.7 (13) |
C6B—C7B—C8B—C9B | −175.3 (5) | C12B—C7B—C6D—C1D | −81.0 (13) |
C7B—C8B—C9B—C10B | 0.9 (7) | C6B—C7B—C6D—C1D | 79.9 (14) |
C8B—C9B—C10B—C11B | −0.7 (6) | C8B—C7B—C6D—C5B | −51.8 (16) |
C8B—C9B—C10B—Br2 | 178.9 (3) | C12B—C7B—C6D—C5B | 121.6 (12) |
C9B—C10B—C11B—C12B | 0.1 (7) | C6B—C7B—C6D—C5B | −78 (2) |
Br2—C10B—C11B—C12B | −179.6 (3) | C19B—O3B—C20B—C21B | 98.4 (16) |
C8B—C7B—C12B—C11B | −0.3 (7) | C20D—O3B—C20B—C21B | 74 (4) |
C6D—C7B—C12B—C11B | −175.0 (5) | C19B—O3B—C20D—C21D | −179 (3) |
C6B—C7B—C12B—C11B | 173.2 (7) | C20B—O3B—C20D—C21D | −20 (3) |
C10B—C11B—C12B—C7B | 0.5 (7) | C19A—O3A—C20A—C21A | −161 (4) |
C3B—C4B—C13B—C14B | 156.9 (4) | C20C—O3A—C20A—C21A | 56 (5) |
C5B—C4B—C13B—C14B | −23.6 (5) | C19A—O3A—C20C—C21C | −99 (2) |
C3B—C4B—C13B—C18B | −24.7 (5) | C20A—O3A—C20C—C21C | −55 (5) |
C5B—C4B—C13B—C18B | 154.7 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
C5A—H5A1···O1Bi | 0.97 | 2.58 | 3.388 (5) | 141 |
C14A—H14A···O1Bi | 0.93 | 2.58 | 3.445 (6) | 154 |
C5B—H5B1···O1Aii | 0.97 | 2.55 | 3.351 (4) | 140 |
C5B—H5B2···O2Aiii | 0.97 | 2.59 | 3.457 (5) | 149 |
Symmetry codes: (i) x, y−1, z−1; (ii) x, y, z+1; (iii) −x+2, −y+1, −z+1. |
Experimental details
Crystal data | |
Chemical formula | C21H18BrFO3 |
Mr | 417.26 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 293 |
a, b, c (Å) | 11.8886 (5), 13.3481 (5), 13.4128 (5) |
α, β, γ (°) | 77.214 (3), 66.757 (4), 87.856 (3) |
V (Å3) | 1904.27 (13) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 2.19 |
Crystal size (mm) | 0.3 × 0.2 × 0.2 |
Data collection | |
Diffractometer | Oxford Diffraction Xcalibur Sapphire3 |
Absorption correction | Multi-scan (CrysAlis PRO; Oxford Diffraction, 2010) |
Tmin, Tmax | 0.816, 1.000 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 27878, 7484, 4086 |
Rint | 0.049 |
(sin θ/λ)max (Å−1) | 0.617 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.054, 0.139, 1.02 |
No. of reflections | 7484 |
No. of parameters | 526 |
No. of restraints | 8 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.49, −0.52 |
Computer programs: CrysAlis PRO (Oxford Diffraction, 2010), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), ORTEP-3 (Farrugia, 1997), PLATON (Spek, 2009).
D—H···A | D—H | H···A | D···A | D—H···A |
C5A—H5A1···O1Bi | 0.97 | 2.58 | 3.388 (5) | 141 |
C14A—H14A···O1Bi | 0.93 | 2.58 | 3.445 (6) | 154 |
C5B—H5B1···O1Aii | 0.97 | 2.55 | 3.351 (4) | 140 |
C5B—H5B2···O2Aiii | 0.97 | 2.59 | 3.457 (5) | 149 |
Symmetry codes: (i) x, y−1, z−1; (ii) x, y, z+1; (iii) −x+2, −y+1, −z+1. |
Acknowledgements
RK acknowledges the Department of Science & Technology for access to the single-crystal X-ray diffractometer sanctioned as a National Facility under project No. SR/S2/CMP-47/2003. BN thanks the UGC for financial assistance through the BSR one-time grant for the purchase of chemicals. MS thanks the DST for providing financial help for the research work through an INSPIRE Fellowship.
References
Butcher, R. J., Akkurt, M., Samshuddin, S., Narayana, B. & Yathirajan, H. S. (2011). Acta Cryst. E67, o1346–o1347. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Duax, W. L. & Norton, D. A. (1975). Atlas of Steroid Structures, Vol. 1. New York: Plenum Press. Google Scholar
Dutkiewicz, G., Narayana, B., Veena, K., Yathirajan, H. S. & Kubicki, M. (2011a). Acta Cryst. E67, o334–o335. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Dutkiewicz, G., Narayana, B., Veena, K., Yathirajan, H. S. & Kubicki, M. (2011b). Acta Cryst. E67, o336. Web of Science CSD CrossRef IUCr Journals Google Scholar
Dutkiewicz, G., Narayana, B., Veena, K., Yathirajan, H. S. & Kubicki, M. (2011c). Acta Cryst. E67, o445–o446. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Farrugia, L. J. (1997). J. Appl. Cryst. 30, 565. CrossRef IUCr Journals Google Scholar
Fun, H.-K., Hemamalini, M., Samshuddin, S., Narayana, B. & Yathirajan, H. S. (2010). Acta Cryst. E66, o864–o865. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Harrison, W. T. A., Mayekar, A. N., Yathirajan, H. S., Narayana, B. & Sarojini, B. K. (2010). Acta Cryst. E66, o2478. Web of Science CSD CrossRef IUCr Journals Google Scholar
Oxford Diffraction (2010). CrysAlis PRO. Oxford Diffraction Ltd, Yarnton, England. Google Scholar
Padmavathi, V., Reddy, B. J. M., Balaiah, A., Reddy, K. V. & Reddy, D. B. (2000). Molecules, 5, 1281–1286. Web of Science CrossRef CAS Google Scholar
Senguttuvan, S. & Nagarajan, S. (2010). Int. J. Chem. 2, 108–112. CrossRef CAS Google Scholar
Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. Web of Science CrossRef CAS IUCr Journals Google Scholar
Spek, A. L. (2009). Acta Cryst. D65, 148–155. Web of Science CrossRef CAS IUCr Journals Google Scholar
Sreevidya, T. V., Narayana, B. & Yathirajan, H. S. (2010). Cent. Eur. J. Chem. 8, 171–181. Web of Science CSD CrossRef Google Scholar
This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
Michael addition of ethyl acetoacetate to chalcones yields 4,6-diaryl-2-oxo -cyclohex-3-ene-1-carboxylate derivatives (Sreevidya et al., 2010), which could be used as efficient synthons for building spiro compounds or as intermediates in the synthesis of isoxazoles, pyrazoles and quinazolines (Padmavathi et al., 2000; Senguttuvan & Nagarajan,2010; Butcher et al., 2011). The crystal structure of some cyclohexenone derivatives, viz., methyl 4,6-bis(4-fluorophenyl)-2-oxo cyclohex-3-ene-1-carboxylate (Fun et al., 2010), (1RS,6SR)-ethyl 4-(4-chlorophenyl)-6-(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate toluene hemisolvate (Dutkiewicz et al., 2011a), (1RS,6SR)-ethyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3]-ene-1-carboxylate (Dutkiewicz et al., 2011b), (1RS,6SR)-ethyl 4-(2,4-dichlorophenyl)-6-(4-fluorophenyl) -2-oxocyclohex-3-ene-1-carboxylate (Dutkiewicz et al.,2011c) and ethyl 4-(2,4-dichlorophenyl)-6-(6-methoxy-2-naphthyl)-2-oxocyclohex-3-ene-1- carboxylate(Harrison et al., 2010) have been reported. In view of the importance of cyclohexenone derivatives, the title compound (I) was prepared and its crystal structure is reported.
In (I) (Fig. 1), all bond lengths and angles are normal and correspond to those to those observed in the related structures (Dutkiewicz et al., 2011a,b,c; Fun et al., 2010; Harrison et al., 2010). The cyclohexene rings have slightly distorted sofa conformations in both the molecules [asymmetry parameters: ΔCs(C3A—C6A) = 4.11 for molecule A; ΔCs(C2B—C5B) = 4.58 /4.65 for molecule B (Duax & Norton, 1975)]. The fluorophenyl and bromophenyl rings are inclined to each other forming dihedral angles of 77.0 (1)° in molecule A and 85.8 (1)° in molecule B. In molecule B, C1 and C6 are disordered over two sites with a 0.53 (2):0.47 (2) ratio. The atoms of the ethyl group were refined as disordered over two sets of sites with occupancies of 0.67 (2)/0.33 (2) and 0.63 (4)/0.37 (4). In the crystal structure C—H···O hydrogen bonds create chains of molecules along the y direction (Table 1, Fig. 2).