organic compounds
6-Hydroxyimino-5α-cholestane
aDepartment of Chemistry, Aligarh Muslim University, Aligarh 202 002, India, bDepartment of Chemistry, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia, and cDepartment of Chemistry, University of Cape Town, Cape Town, South Africa
*Correspondence e-mail: shamsuzzaman9@gmail.com
The title compound, C27H47NO, is a steroid derivative composed of a saturated carbon fused-ring framework with an alkyl side chain. Ring bond lengths have normal values with an average of 1.533 (2) Å, while the cholestane side chain shows an average bond length of 1.533 (2) Å. The three cyclohexane rings adopt chair conformations or close to chair conformations while the cyclopentane ring is twisted. The cholesterol side-chain is fully extended with a gauche–trans conformation of the terminal methyl groups. There are eight chiral centres in the molecule; the of these sites was determined from the structure presented. There are two molecules in the in one, the alkyl chain is disordered over two sets of sites [occupancy ratios of 0.50:0.50 and 0.67:0.33].
Related literature
For background on steroidal hormone applications, see: Grover et al. (2007). For background to this study and previous syntheses, see: Shoppee et al. (1955). For related structures, see: Ketuly et al. (2011); Park (2004). For reference bond-length data, see: Allen et al. (1987). For the stability of the temperature controller used for the data collection, see: Cosier & Glazer (1986).
Experimental
Crystal data
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Data collection: APEX2 (Bruker, 2008); cell APEX2; data reduction: APEX2; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: publCIF (Westrip, 2010).
Supporting information
https://doi.org/10.1107/S1600536812040093/hg5240sup1.cif
contains datablocks I, global. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536812040093/hg5240Isup2.hkl
5α-Cholest-6-one (1.0 g) was dissolved in ethanol (60 ml) and to this, hydroxylamine hydrochloride (1.0 g) and sodium acetate trihydrate (2.0 g) were added. The reaction mixture was refluxed for 4 h. Dilution with cold water gave crude oxime, which was filtered, washed with water and air dried. Recrystallization from ethanol gave crystals of product. m.p. 482 K (reported m.p. 477 K; Shoppee et al. 1955). The crystal was placed in the cold stream of an Oxford Cyrosystems Cobra open-flow nitrogen cryostat (Cosier & Glazer, 1986) operating at 100.0 (1) K.
All H atoms were positioned geometrically [C—H = 0.98–1.00 Å] and were refined using a riding model, with Uiso(H) = 1.2–1.5Ueq(C). H atoms attached to O atom were positioned with idealized geometry and were refined isotropically with Ueq(H) set to 1.5 times of Ueq(O) using a riding model with O—H = 0.87 Å. In the absence of significant
Friedel pairs were merged and the was assigned arbitrarily. Friedel pairs have been merged using MERG 3, which makes the Flack x parameter meaningless and therefore has been removed from the final file.There are two molecules in the
and only alkyl chain (C23a—C25a) of one molecule is disordered. C23a and C25a are disordered over two positions with site occupancy factors of 50% while C24a is disordered over two positions with site occupancy factors of 33% and 67%.Steroids are compounds of biological origin and play an important role in biological systems. The dramatic expansion of steroidal chemistry came with the discovery of steroidal hormones. The discovery of several
with their wide application in therapy has brought about an increasing interest (Grover et al., 2007). A series of crystal structures of hydroxyiminocholestane (Ketuly et al., 2011) and derivatives of cholesterol (Park, 2004) have been examined in order to obtain structural information relevant to the liquid crystalline phases and the possible modes of association of the cholesterol derivatives themselves.In the view of the biological importance of cholesterol derivatives, we report here the
of the title compound (I). There are two molecules in the (Fig. 1), while contains 4 molecules (Fig. 2). The ring bond lengths have normal values (Allen et al., 1987) with average C(sp3)—C(sp3) of 1.533 (2) Å, excluding the shorter C1—C62 bond of 1.496 (2) Å. The cholestane side-chain shows C(sp3)—C(sp3) bond lengths varying from C25—C26 [1.525 (2) Å] up to C20—C22 [1.539 (2) Å]. Each of the six-member rings adopts a chair conformation or close to a chair conformation, and the five-member ring has a twisted conformation. There are eight chiral centres in the molecule, the of these sites was determined from the structure presented, these sites exhibit the following chiralities: C2= S, C7 = R, C8 = S, C11 = R, C12 = R, C15 = S, C16 = S and C20 = R.For background on steroidal hormone applications, see: Grover et al. (2007). For background to this study and previous syntheses, see: Shoppee et al. (1955). For related structures, see: Ketuly et al. (2011); Park (2004). For reference bond-length data, see: Allen et al. (1987). For the stability of the temperature controller used for the data collection, see: Cosier & Glazer (1986).
Data collection: APEX2 (Bruker, 2008); cell
APEX2 (Bruker, 2008); data reduction: APEX2 (Bruker, 2008); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: publCIF (Westrip, 2010).Fig. 1. The molecular structure of (I) showing the atomic numbering and 30% probability displacement ellipsoids. | |
Fig. 2. The unit cell diagram projected down the b axis. |
C27H47NO | F(000) = 896 |
Mr = 401.65 | Dx = 1.118 Mg m−3 |
Monoclinic, P21 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2yb | Cell parameters from 10665 reflections |
a = 13.7535 (7) Å | θ = 1.7–30.6° |
b = 9.5266 (4) Å | µ = 0.07 mm−1 |
c = 18.681 (1) Å | T = 100 K |
β = 102.829 (3)° | Plate, colourless |
V = 2386.6 (2) Å3 | 0.54 × 0.31 × 0.17 mm |
Z = 4 |
Bruker Kappa APEXII Duo diffractometer | 7706 independent reflections |
Radiation source: fine-focus sealed tube | 6021 reflections with I > 2σ(I) |
Triumph monochromator | Rint = 0.052 |
Detector resolution: 0 pixels mm-1 | θmax = 30.6°, θmin = 1.7° |
ω and φ scans | h = −18→19 |
Absorption correction: multi-scan (Blessing, 1995) | k = −13→13 |
Tmin = 0.965, Tmax = 0.989 | l = −26→26 |
51587 measured reflections |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.049 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.129 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.12 | w = 1/[σ2(Fo2) + (0.0568P)2 + 0.5458P] where P = (Fo2 + 2Fc2)/3 |
7706 reflections | (Δ/σ)max = 0.005 |
564 parameters | Δρmax = 0.48 e Å−3 |
59 restraints | Δρmin = −0.32 e Å−3 |
C27H47NO | V = 2386.6 (2) Å3 |
Mr = 401.65 | Z = 4 |
Monoclinic, P21 | Mo Kα radiation |
a = 13.7535 (7) Å | µ = 0.07 mm−1 |
b = 9.5266 (4) Å | T = 100 K |
c = 18.681 (1) Å | 0.54 × 0.31 × 0.17 mm |
β = 102.829 (3)° |
Bruker Kappa APEXII Duo diffractometer | 7706 independent reflections |
Absorption correction: multi-scan (Blessing, 1995) | 6021 reflections with I > 2σ(I) |
Tmin = 0.965, Tmax = 0.989 | Rint = 0.052 |
51587 measured reflections |
R[F2 > 2σ(F2)] = 0.049 | 59 restraints |
wR(F2) = 0.129 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.12 | Δρmax = 0.48 e Å−3 |
7706 reflections | Δρmin = −0.32 e Å−3 |
564 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
O1A | 0.61310 (13) | 0.1041 (2) | 0.17724 (10) | 0.0271 (4) | |
H1A | 0.585 (2) | 0.091 (4) | 0.1311 (19) | 0.041* | |
C1A | 0.77678 (17) | 0.0812 (2) | 0.22893 (13) | 0.0190 (4) | |
N1A | 0.71254 (15) | 0.0947 (2) | 0.16853 (11) | 0.0223 (4) | |
C2A | 0.88428 (18) | 0.0668 (3) | 0.22606 (13) | 0.0217 (5) | |
H2A | 0.9058 | −0.0269 | 0.2481 | 0.026* | |
C3A | 0.9035 (2) | 0.0630 (3) | 0.14838 (14) | 0.0307 (6) | |
H3A1 | 0.8627 | −0.0120 | 0.1196 | 0.037* | |
H3A2 | 0.8836 | 0.1537 | 0.1236 | 0.037* | |
C4A | 1.0132 (2) | 0.0357 (4) | 0.15124 (16) | 0.0403 (8) | |
H4A1 | 1.0317 | −0.0584 | 0.1723 | 0.048* | |
H4A2 | 1.0250 | 0.0373 | 0.1008 | 0.048* | |
C5A | 1.0775 (2) | 0.1455 (4) | 0.19742 (17) | 0.0402 (8) | |
H5A1 | 1.0633 | 0.2384 | 0.1736 | 0.048* | |
H5A2 | 1.1486 | 0.1235 | 0.2002 | 0.048* | |
C6A | 1.05897 (18) | 0.1526 (3) | 0.27529 (16) | 0.0296 (6) | |
H6A1 | 1.0996 | 0.2296 | 0.3023 | 0.036* | |
H6A2 | 1.0818 | 0.0637 | 0.3011 | 0.036* | |
C7A | 0.94860 (17) | 0.1770 (3) | 0.27754 (15) | 0.0216 (5) | |
C8A | 0.93347 (16) | 0.1497 (2) | 0.35607 (13) | 0.0183 (4) | |
H8A | 0.9522 | 0.0493 | 0.3672 | 0.022* | |
C9A | 1.00016 (18) | 0.2365 (3) | 0.41720 (15) | 0.0260 (5) | |
H9A1 | 1.0707 | 0.2227 | 0.4149 | 0.031* | |
H9A2 | 0.9842 | 0.3372 | 0.4084 | 0.031* | |
C10A | 0.98758 (18) | 0.1972 (3) | 0.49393 (15) | 0.0251 (5) | |
H10A | 1.0290 | 0.2607 | 0.5303 | 0.030* | |
H10B | 1.0121 | 0.1003 | 0.5053 | 0.030* | |
C11A | 0.87903 (17) | 0.2066 (2) | 0.50136 (13) | 0.0205 (5) | |
C12A | 0.85108 (17) | 0.1293 (3) | 0.56717 (13) | 0.0218 (5) | |
H12A | 0.8823 | 0.0341 | 0.5697 | 0.026* | |
C13A | 0.73665 (18) | 0.1076 (3) | 0.54132 (13) | 0.0255 (5) | |
H13A | 0.7170 | 0.0157 | 0.5584 | 0.031* | |
H13B | 0.7003 | 0.1825 | 0.5612 | 0.031* | |
C14A | 0.71249 (17) | 0.1130 (3) | 0.45644 (13) | 0.0227 (5) | |
H14A | 0.6756 | 0.0282 | 0.4351 | 0.027* | |
H14B | 0.6726 | 0.1973 | 0.4380 | 0.027* | |
C15A | 0.81518 (16) | 0.1194 (2) | 0.43825 (13) | 0.0188 (4) | |
H15A | 0.8422 | 0.0217 | 0.4451 | 0.023* | |
C16A | 0.82378 (16) | 0.1631 (2) | 0.36144 (13) | 0.0185 (4) | |
H16A | 0.8028 | 0.2634 | 0.3534 | 0.022* | |
C17A | 0.75460 (17) | 0.0716 (3) | 0.30388 (13) | 0.0213 (5) | |
H17A | 0.7611 | −0.0275 | 0.3203 | 0.026* | |
H17B | 0.6847 | 0.1007 | 0.3008 | 0.026* | |
C18A | 0.9167 (2) | 0.3268 (3) | 0.25160 (17) | 0.0309 (6) | |
H18A | 0.9526 | 0.3948 | 0.2873 | 0.046* | |
H18B | 0.8448 | 0.3374 | 0.2473 | 0.046* | |
H18C | 0.9326 | 0.3436 | 0.2037 | 0.046* | |
C19A | 0.84505 (19) | 0.3604 (3) | 0.49939 (15) | 0.0243 (5) | |
H19A | 0.8492 | 0.4024 | 0.4523 | 0.036* | |
H19B | 0.8883 | 0.4123 | 0.5394 | 0.036* | |
H19C | 0.7760 | 0.3646 | 0.5052 | 0.036* | |
C20A | 0.8800 (2) | 0.1919 (3) | 0.64513 (14) | 0.0262 (5) | |
H20A | 0.8443 | 0.2833 | 0.6453 | 0.031* | |
C21A | 0.9927 (2) | 0.2192 (3) | 0.66857 (16) | 0.0366 (7) | |
H21A | 1.0102 | 0.2433 | 0.7209 | 0.055* | |
H21B | 1.0107 | 0.2971 | 0.6398 | 0.055* | |
H21C | 1.0290 | 0.1346 | 0.6600 | 0.055* | |
C22A | 0.8456 (2) | 0.0920 (3) | 0.69885 (14) | 0.0283 (6) | |
H22A | 0.8951 | 0.0151 | 0.7104 | 0.034* | |
H22B | 0.7818 | 0.0493 | 0.6730 | 0.034* | |
C23A | 0.8299 (5) | 0.1538 (7) | 0.7740 (3) | 0.0367 (14) | 0.50 |
H23A | 0.8899 | 0.2111 | 0.7940 | 0.044* | 0.50 |
H23B | 0.7736 | 0.2206 | 0.7609 | 0.044* | 0.50 |
C24A | 0.8103 (6) | 0.0677 (10) | 0.8393 (4) | 0.0321 (18) | 0.33 |
H24A | 0.7725 | −0.0175 | 0.8195 | 0.039* | 0.33 |
H24B | 0.7669 | 0.1240 | 0.8640 | 0.039* | 0.33 |
C25A | 0.9059 (3) | 0.0193 (5) | 0.9001 (2) | 0.0192 (9) | 0.50 |
H25A | 0.9619 | −0.0205 | 0.8803 | 0.023* | 0.50 |
C23C | 0.8831 (5) | 0.1306 (6) | 0.7778 (3) | 0.0309 (12) | 0.50 |
H23C | 0.8570 | 0.2238 | 0.7875 | 0.037* | 0.50 |
H23D | 0.9569 | 0.1354 | 0.7895 | 0.037* | 0.50 |
C24C | 0.8488 (3) | 0.0208 (4) | 0.82512 (18) | 0.0195 (7) | 0.67 |
H24C | 0.7828 | −0.0124 | 0.7978 | 0.023* | 0.67 |
H24D | 0.8951 | −0.0597 | 0.8282 | 0.023* | 0.67 |
C25C | 0.8391 (4) | 0.0519 (6) | 0.9022 (3) | 0.0339 (12) | 0.50 |
H25C | 0.7727 | 0.0940 | 0.9029 | 0.041* | 0.50 |
C26A | 0.9295 (3) | 0.1526 (3) | 0.94258 (16) | 0.0392 (7) | |
H26D | 0.9898 | 0.1411 | 0.9811 | 0.059* | 0.50 |
H26E | 0.9417 | 0.2269 | 0.9105 | 0.059* | 0.50 |
H26F | 0.8759 | 0.1782 | 0.9645 | 0.059* | 0.50 |
H26G | 0.9264 | 0.2414 | 0.9176 | 0.059* | 0.50 |
H26H | 0.9261 | 0.1672 | 0.9925 | 0.059* | 0.50 |
H26I | 0.9938 | 0.1094 | 0.9417 | 0.059* | 0.50 |
C27A | 0.8563 (3) | −0.0864 (3) | 0.94673 (17) | 0.0457 (8) | |
H27D | 0.9057 | −0.1284 | 0.9857 | 0.069* | 0.50 |
H27E | 0.8078 | −0.0387 | 0.9680 | 0.069* | 0.50 |
H27F | 0.8231 | −0.1605 | 0.9151 | 0.069* | 0.50 |
H27G | 0.8061 | −0.1545 | 0.9264 | 0.069* | 0.50 |
H27H | 0.9211 | −0.1246 | 0.9457 | 0.069* | 0.50 |
H27I | 0.8534 | −0.0668 | 0.9964 | 0.069* | 0.50 |
O1B | 0.33906 (12) | 0.5733 (2) | −0.01531 (10) | 0.0226 (4) | |
H1B | 0.306 (2) | 0.588 (4) | −0.0599 (18) | 0.034* | |
C1B | 0.49582 (17) | 0.4940 (2) | 0.02841 (12) | 0.0170 (4) | |
N1B | 0.43489 (14) | 0.5418 (2) | −0.02822 (10) | 0.0178 (4) | |
C2B | 0.59958 (17) | 0.4588 (2) | 0.02224 (12) | 0.0166 (4) | |
H2B | 0.6128 | 0.3617 | 0.0423 | 0.020* | |
C3B | 0.61520 (18) | 0.4535 (3) | −0.05631 (12) | 0.0203 (5) | |
H3B1 | 0.5658 | 0.3891 | −0.0861 | 0.024* | |
H3B2 | 0.6048 | 0.5481 | −0.0786 | 0.024* | |
C4B | 0.72015 (18) | 0.4031 (3) | −0.05655 (13) | 0.0222 (5) | |
H4B1 | 0.7304 | 0.4051 | −0.1074 | 0.027* | |
H4B2 | 0.7283 | 0.3049 | −0.0388 | 0.027* | |
C5B | 0.79807 (19) | 0.4957 (3) | −0.00758 (14) | 0.0233 (5) | |
H5B1 | 0.7953 | 0.5911 | −0.0289 | 0.028* | |
H5B2 | 0.8653 | 0.4569 | −0.0058 | 0.028* | |
C6B | 0.78092 (17) | 0.5050 (3) | 0.07050 (13) | 0.0216 (5) | |
H6B1 | 0.8308 | 0.5699 | 0.0995 | 0.026* | |
H6B2 | 0.7920 | 0.4112 | 0.0937 | 0.026* | |
C7B | 0.67551 (16) | 0.5563 (2) | 0.07400 (12) | 0.0163 (4) | |
C8B | 0.65899 (16) | 0.5382 (2) | 0.15342 (12) | 0.0159 (4) | |
H8B | 0.6737 | 0.4376 | 0.1670 | 0.019* | |
C9B | 0.73071 (17) | 0.6262 (3) | 0.21092 (13) | 0.0198 (5) | |
H9B1 | 0.7220 | 0.7265 | 0.1971 | 0.024* | |
H9B2 | 0.8001 | 0.5997 | 0.2102 | 0.024* | |
C10B | 0.71515 (17) | 0.6082 (3) | 0.28966 (12) | 0.0197 (5) | |
H10C | 0.7340 | 0.5115 | 0.3067 | 0.024* | |
H10D | 0.7595 | 0.6740 | 0.3228 | 0.024* | |
C11B | 0.60703 (16) | 0.6356 (2) | 0.29422 (12) | 0.0156 (4) | |
C12B | 0.57603 (17) | 0.5883 (2) | 0.36572 (12) | 0.0182 (4) | |
H12B | 0.6061 | 0.4937 | 0.3793 | 0.022* | |
C13B | 0.46118 (18) | 0.5684 (3) | 0.34010 (12) | 0.0200 (5) | |
H13C | 0.4393 | 0.4856 | 0.3644 | 0.024* | |
H13D | 0.4258 | 0.6522 | 0.3526 | 0.024* | |
C14B | 0.43838 (18) | 0.5467 (3) | 0.25580 (12) | 0.0199 (5) | |
H14C | 0.4000 | 0.4593 | 0.2417 | 0.024* | |
H14D | 0.4001 | 0.6269 | 0.2300 | 0.024* | |
C15B | 0.54085 (16) | 0.5372 (2) | 0.23794 (11) | 0.0156 (4) | |
H15B | 0.5655 | 0.4396 | 0.2504 | 0.019* | |
C16B | 0.54998 (16) | 0.5646 (2) | 0.15896 (11) | 0.0149 (4) | |
H16B | 0.5341 | 0.6657 | 0.1475 | 0.018* | |
C17B | 0.47601 (17) | 0.4750 (3) | 0.10383 (12) | 0.0188 (5) | |
H17C | 0.4837 | 0.3749 | 0.1182 | 0.023* | |
H17D | 0.4069 | 0.5040 | 0.1038 | 0.023* | |
C18B | 0.66091 (19) | 0.7094 (2) | 0.04869 (14) | 0.0215 (5) | |
H18D | 0.7133 | 0.7676 | 0.0786 | 0.032* | |
H18E | 0.5955 | 0.7425 | 0.0543 | 0.032* | |
H18F | 0.6646 | 0.7160 | −0.0030 | 0.032* | |
C19B | 0.57851 (18) | 0.7902 (2) | 0.27894 (13) | 0.0191 (4) | |
H19D | 0.6164 | 0.8486 | 0.3186 | 0.029* | |
H19E | 0.5070 | 0.8021 | 0.2762 | 0.029* | |
H19F | 0.5939 | 0.8185 | 0.2322 | 0.029* | |
C20B | 0.60358 (18) | 0.6827 (2) | 0.43447 (12) | 0.0198 (5) | |
H20B | 0.5677 | 0.7740 | 0.4226 | 0.024* | |
C21B | 0.71555 (19) | 0.7145 (3) | 0.45636 (14) | 0.0264 (5) | |
H21D | 0.7307 | 0.7631 | 0.5038 | 0.040* | |
H21E | 0.7344 | 0.7743 | 0.4190 | 0.040* | |
H21F | 0.7532 | 0.6264 | 0.4603 | 0.040* | |
C22B | 0.5687 (2) | 0.6171 (3) | 0.49985 (13) | 0.0235 (5) | |
H22C | 0.5019 | 0.5749 | 0.4820 | 0.028* | |
H22D | 0.6153 | 0.5410 | 0.5211 | 0.028* | |
C23B | 0.5635 (2) | 0.7249 (3) | 0.55994 (13) | 0.0257 (5) | |
H23E | 0.6270 | 0.7778 | 0.5710 | 0.031* | |
H23F | 0.5097 | 0.7925 | 0.5399 | 0.031* | |
C24B | 0.54498 (18) | 0.6672 (3) | 0.63243 (13) | 0.0223 (5) | |
H24E | 0.5053 | 0.7372 | 0.6529 | 0.027* | |
H24F | 0.5039 | 0.5812 | 0.6215 | 0.027* | |
C25B | 0.63789 (17) | 0.6318 (3) | 0.69153 (12) | 0.0195 (5) | |
H25B | 0.6852 | 0.7126 | 0.6951 | 0.023* | |
C26B | 0.61099 (19) | 0.6148 (3) | 0.76606 (13) | 0.0242 (5) | |
H26A | 0.5760 | 0.6990 | 0.7770 | 0.036* | |
H26B | 0.6720 | 0.6017 | 0.8041 | 0.036* | |
H26C | 0.5677 | 0.5328 | 0.7649 | 0.036* | |
C27B | 0.69108 (19) | 0.5011 (3) | 0.67274 (15) | 0.0273 (5) | |
H27A | 0.7462 | 0.4775 | 0.7140 | 0.041* | |
H27B | 0.7173 | 0.5192 | 0.6289 | 0.041* | |
H27C | 0.6439 | 0.4226 | 0.6632 | 0.041* |
U11 | U22 | U33 | U12 | U13 | U23 | |
O1A | 0.0173 (8) | 0.0416 (11) | 0.0223 (9) | −0.0053 (8) | 0.0042 (7) | −0.0046 (8) |
C1A | 0.0198 (11) | 0.0177 (10) | 0.0207 (11) | −0.0026 (9) | 0.0069 (9) | −0.0005 (8) |
N1A | 0.0184 (9) | 0.0247 (10) | 0.0253 (10) | −0.0018 (8) | 0.0079 (8) | −0.0001 (8) |
C2A | 0.0210 (11) | 0.0218 (11) | 0.0240 (12) | 0.0049 (9) | 0.0087 (9) | 0.0053 (9) |
C3A | 0.0287 (14) | 0.0415 (16) | 0.0249 (13) | 0.0109 (12) | 0.0124 (10) | 0.0111 (11) |
C4A | 0.0325 (15) | 0.063 (2) | 0.0299 (14) | 0.0213 (15) | 0.0167 (12) | 0.0167 (14) |
C5A | 0.0210 (13) | 0.061 (2) | 0.0428 (17) | 0.0150 (14) | 0.0167 (12) | 0.0300 (15) |
C6A | 0.0132 (11) | 0.0363 (15) | 0.0406 (15) | 0.0057 (10) | 0.0085 (10) | 0.0173 (12) |
C7A | 0.0127 (11) | 0.0193 (11) | 0.0330 (13) | 0.0022 (9) | 0.0050 (9) | 0.0083 (9) |
C8A | 0.0123 (10) | 0.0137 (10) | 0.0285 (12) | 0.0013 (8) | 0.0038 (9) | 0.0010 (9) |
C9A | 0.0122 (11) | 0.0239 (12) | 0.0409 (15) | −0.0034 (9) | 0.0040 (10) | −0.0065 (11) |
C10A | 0.0131 (11) | 0.0268 (12) | 0.0324 (13) | 0.0005 (9) | −0.0016 (9) | −0.0082 (10) |
C11A | 0.0146 (11) | 0.0177 (10) | 0.0266 (12) | 0.0021 (9) | −0.0008 (9) | −0.0087 (9) |
C12A | 0.0191 (11) | 0.0169 (10) | 0.0272 (12) | 0.0041 (9) | 0.0004 (9) | −0.0058 (9) |
C13A | 0.0210 (12) | 0.0317 (13) | 0.0233 (12) | 0.0020 (10) | 0.0034 (9) | −0.0073 (10) |
C14A | 0.0171 (11) | 0.0267 (12) | 0.0233 (12) | −0.0015 (9) | 0.0021 (9) | −0.0069 (10) |
C15A | 0.0131 (10) | 0.0177 (10) | 0.0248 (11) | −0.0001 (8) | 0.0022 (8) | −0.0062 (9) |
C16A | 0.0121 (10) | 0.0161 (10) | 0.0263 (12) | −0.0014 (8) | 0.0021 (8) | −0.0034 (8) |
C17A | 0.0156 (10) | 0.0253 (12) | 0.0233 (11) | −0.0061 (9) | 0.0049 (8) | −0.0036 (9) |
C18A | 0.0222 (13) | 0.0222 (12) | 0.0464 (17) | 0.0007 (10) | 0.0033 (11) | 0.0111 (11) |
C19A | 0.0215 (12) | 0.0184 (11) | 0.0308 (14) | 0.0040 (9) | 0.0009 (10) | −0.0064 (9) |
C20A | 0.0322 (14) | 0.0173 (11) | 0.0240 (12) | 0.0035 (10) | −0.0048 (10) | −0.0034 (9) |
C21A | 0.0397 (16) | 0.0263 (13) | 0.0333 (15) | −0.0116 (12) | −0.0142 (12) | 0.0052 (11) |
C22A | 0.0265 (13) | 0.0225 (12) | 0.0305 (14) | 0.0031 (10) | −0.0054 (10) | 0.0008 (10) |
C23A | 0.042 (2) | 0.036 (2) | 0.030 (2) | −0.0142 (17) | 0.0005 (17) | 0.0047 (16) |
C24A | 0.036 (3) | 0.031 (2) | 0.027 (2) | −0.0029 (19) | 0.0029 (18) | 0.0015 (18) |
C25A | 0.0153 (16) | 0.0239 (16) | 0.0203 (16) | 0.0007 (14) | 0.0080 (13) | −0.0069 (14) |
C23C | 0.041 (2) | 0.0281 (19) | 0.0241 (18) | −0.0026 (17) | 0.0079 (16) | 0.0001 (15) |
C24C | 0.0178 (13) | 0.0242 (14) | 0.0176 (13) | 0.0039 (12) | 0.0060 (11) | 0.0027 (11) |
C25C | 0.036 (2) | 0.0318 (19) | 0.0330 (19) | 0.0023 (16) | 0.0065 (16) | 0.0014 (16) |
C26A | 0.0529 (15) | 0.0336 (13) | 0.0274 (12) | 0.0046 (12) | 0.0009 (11) | −0.0019 (10) |
C27A | 0.0711 (17) | 0.0354 (13) | 0.0297 (13) | −0.0002 (13) | 0.0092 (12) | 0.0034 (11) |
O1B | 0.0138 (8) | 0.0315 (9) | 0.0222 (8) | 0.0029 (7) | 0.0037 (6) | −0.0031 (7) |
C1B | 0.0194 (11) | 0.0167 (10) | 0.0158 (10) | −0.0029 (8) | 0.0054 (8) | −0.0015 (8) |
N1B | 0.0136 (9) | 0.0205 (9) | 0.0198 (9) | 0.0000 (7) | 0.0049 (7) | −0.0024 (7) |
C2B | 0.0200 (11) | 0.0151 (10) | 0.0155 (10) | 0.0004 (8) | 0.0055 (8) | 0.0005 (8) |
C3B | 0.0216 (12) | 0.0244 (11) | 0.0163 (10) | 0.0010 (9) | 0.0071 (9) | −0.0002 (9) |
C4B | 0.0253 (12) | 0.0220 (11) | 0.0216 (12) | 0.0050 (10) | 0.0103 (10) | 0.0012 (9) |
C5B | 0.0206 (12) | 0.0250 (12) | 0.0267 (12) | 0.0034 (10) | 0.0107 (10) | 0.0013 (9) |
C6B | 0.0172 (11) | 0.0268 (12) | 0.0222 (12) | 0.0026 (9) | 0.0078 (9) | 0.0017 (9) |
C7B | 0.0148 (10) | 0.0166 (10) | 0.0177 (10) | −0.0002 (8) | 0.0039 (8) | 0.0015 (8) |
C8B | 0.0160 (10) | 0.0167 (10) | 0.0152 (10) | 0.0001 (8) | 0.0038 (8) | 0.0007 (8) |
C9B | 0.0151 (10) | 0.0218 (11) | 0.0224 (11) | −0.0009 (9) | 0.0042 (8) | −0.0029 (9) |
C10B | 0.0162 (10) | 0.0237 (11) | 0.0180 (11) | 0.0041 (9) | 0.0014 (8) | −0.0025 (9) |
C11B | 0.0161 (10) | 0.0140 (10) | 0.0161 (10) | 0.0013 (8) | 0.0020 (8) | −0.0011 (8) |
C12B | 0.0235 (11) | 0.0143 (10) | 0.0167 (10) | 0.0030 (9) | 0.0043 (8) | −0.0003 (8) |
C13B | 0.0258 (12) | 0.0203 (11) | 0.0155 (10) | −0.0027 (9) | 0.0078 (9) | −0.0011 (8) |
C14B | 0.0221 (11) | 0.0230 (11) | 0.0160 (10) | −0.0067 (9) | 0.0073 (8) | −0.0017 (8) |
C15B | 0.0194 (11) | 0.0138 (9) | 0.0136 (10) | −0.0024 (8) | 0.0034 (8) | −0.0009 (7) |
C16B | 0.0149 (10) | 0.0165 (10) | 0.0138 (9) | −0.0009 (8) | 0.0039 (7) | −0.0002 (7) |
C17B | 0.0182 (11) | 0.0220 (11) | 0.0172 (10) | −0.0029 (9) | 0.0060 (9) | −0.0013 (8) |
C18B | 0.0257 (12) | 0.0155 (10) | 0.0250 (12) | −0.0008 (9) | 0.0091 (10) | 0.0029 (9) |
C19B | 0.0206 (11) | 0.0131 (10) | 0.0231 (11) | 0.0001 (8) | 0.0041 (9) | 0.0012 (8) |
C20B | 0.0236 (12) | 0.0168 (10) | 0.0183 (11) | 0.0028 (9) | 0.0028 (9) | −0.0012 (8) |
C21B | 0.0278 (13) | 0.0280 (12) | 0.0216 (12) | 0.0054 (11) | 0.0018 (10) | −0.0073 (10) |
C22B | 0.0344 (14) | 0.0190 (11) | 0.0166 (11) | 0.0018 (10) | 0.0045 (9) | −0.0017 (9) |
C23B | 0.0396 (15) | 0.0200 (11) | 0.0170 (11) | 0.0050 (11) | 0.0052 (10) | −0.0013 (9) |
C24B | 0.0241 (12) | 0.0232 (11) | 0.0189 (11) | 0.0023 (10) | 0.0032 (9) | −0.0018 (9) |
C25B | 0.0167 (10) | 0.0220 (11) | 0.0197 (11) | −0.0029 (9) | 0.0036 (8) | −0.0008 (9) |
C26B | 0.0266 (13) | 0.0277 (12) | 0.0186 (11) | −0.0024 (10) | 0.0053 (9) | 0.0004 (10) |
C27B | 0.0206 (12) | 0.0335 (14) | 0.0264 (13) | 0.0058 (11) | 0.0020 (10) | −0.0035 (11) |
O1A—N1A | 1.416 (3) | C26A—H26H | 0.9543 |
O1A—H1A | 0.87 (3) | C26A—H26I | 0.9786 |
C1A—N1A | 1.276 (3) | C27A—H27D | 0.9659 |
C1A—C17A | 1.501 (3) | C27A—H27E | 0.9622 |
C1A—C2A | 1.498 (3) | C27A—H27F | 0.9675 |
C2A—C3A | 1.532 (3) | C27A—H27G | 0.9617 |
C2A—C7A | 1.559 (4) | C27A—H27H | 0.9675 |
C2A—H2A | 1.0000 | C27A—H27I | 0.9558 |
C3A—C4A | 1.520 (4) | O1B—N1B | 1.423 (2) |
C3A—H3A1 | 0.9900 | O1B—H1B | 0.87 (3) |
C3A—H3A2 | 0.9900 | C1B—N1B | 1.279 (3) |
C4A—C5A | 1.511 (5) | C1B—C2B | 1.495 (3) |
C4A—H4A1 | 0.9900 | C1B—C17B | 1.504 (3) |
C4A—H4A2 | 0.9900 | C2B—C3B | 1.530 (3) |
C5A—C6A | 1.533 (4) | C2B—C7B | 1.562 (3) |
C5A—H5A1 | 0.9900 | C2B—H2B | 1.0000 |
C5A—H5A2 | 0.9900 | C3B—C4B | 1.522 (3) |
C6A—C7A | 1.545 (3) | C3B—H3B1 | 0.9900 |
C6A—H6A1 | 0.9900 | C3B—H3B2 | 0.9900 |
C6A—H6A2 | 0.9900 | C4B—C5B | 1.526 (4) |
C7A—C18A | 1.539 (3) | C4B—H4B1 | 0.9900 |
C7A—C8A | 1.549 (3) | C4B—H4B2 | 0.9900 |
C8A—C16A | 1.539 (3) | C5B—C6B | 1.531 (3) |
C8A—C9A | 1.538 (3) | C5B—H5B1 | 0.9900 |
C8A—H8A | 1.0000 | C5B—H5B2 | 0.9900 |
C9A—C10A | 1.528 (4) | C6B—C7B | 1.545 (3) |
C9A—H9A1 | 0.9900 | C6B—H6B1 | 0.9900 |
C9A—H9A2 | 0.9900 | C6B—H6B2 | 0.9900 |
C10A—C11A | 1.532 (3) | C7B—C18B | 1.533 (3) |
C10A—H10A | 0.9900 | C7B—C8B | 1.559 (3) |
C10A—H10B | 0.9900 | C8B—C9B | 1.536 (3) |
C11A—C19A | 1.536 (3) | C8B—C16B | 1.546 (3) |
C11A—C15A | 1.546 (3) | C8B—H8B | 1.0000 |
C11A—C12A | 1.553 (4) | C9B—C10B | 1.542 (3) |
C12A—C20A | 1.542 (3) | C9B—H9B1 | 0.9900 |
C12A—C13A | 1.554 (3) | C9B—H9B2 | 0.9900 |
C12A—H12A | 1.0000 | C10B—C11B | 1.531 (3) |
C13A—C14A | 1.547 (3) | C10B—H10C | 0.9900 |
C13A—H13A | 0.9900 | C10B—H10D | 0.9900 |
C13A—H13B | 0.9900 | C11B—C19B | 1.534 (3) |
C14A—C15A | 1.526 (3) | C11B—C15B | 1.545 (3) |
C14A—H14A | 0.9900 | C11B—C12B | 1.556 (3) |
C14A—H14B | 0.9900 | C12B—C20B | 1.545 (3) |
C15A—C16A | 1.523 (3) | C12B—C13B | 1.557 (3) |
C15A—H15A | 1.0000 | C12B—H12B | 1.0000 |
C16A—C17A | 1.539 (3) | C13B—C14B | 1.550 (3) |
C16A—H16A | 1.0000 | C13B—H13C | 0.9900 |
C17A—H17A | 0.9900 | C13B—H13D | 0.9900 |
C17A—H17B | 0.9900 | C14B—C15B | 1.521 (3) |
C18A—H18A | 0.9800 | C14B—H14C | 0.9900 |
C18A—H18B | 0.9800 | C14B—H14D | 0.9900 |
C18A—H18C | 0.9800 | C15B—C16B | 1.531 (3) |
C19A—H19A | 0.9800 | C15B—H15B | 1.0000 |
C19A—H19B | 0.9800 | C16B—C17B | 1.536 (3) |
C19A—H19C | 0.9800 | C16B—H16B | 1.0000 |
C20A—C21A | 1.536 (4) | C17B—H17C | 0.9900 |
C20A—C22A | 1.532 (4) | C17B—H17D | 0.9900 |
C20A—H20A | 1.0000 | C18B—H18D | 0.9800 |
C21A—H21A | 0.9800 | C18B—H18E | 0.9800 |
C21A—H21B | 0.9800 | C18B—H18F | 0.9800 |
C21A—H21C | 0.9800 | C19B—H19D | 0.9800 |
C22A—C23C | 1.496 (5) | C19B—H19E | 0.9800 |
C22A—C23A | 1.581 (6) | C19B—H19F | 0.9800 |
C22A—H22A | 0.9900 | C20B—C21B | 1.533 (4) |
C22A—H22B | 0.9900 | C20B—C22B | 1.541 (3) |
C23A—C24A | 1.542 (7) | C20B—H20B | 1.0000 |
C23A—H23A | 0.9900 | C21B—H21D | 0.9800 |
C23A—H23B | 0.9900 | C21B—H21E | 0.9800 |
C24A—C25A | 1.603 (7) | C21B—H21F | 0.9800 |
C24A—H24A | 0.9900 | C22B—C23B | 1.535 (3) |
C24A—H24B | 0.9900 | C22B—H22C | 0.9900 |
C25A—C26A | 1.494 (5) | C22B—H22D | 0.9900 |
C25A—C27A | 1.582 (5) | C23B—C24B | 1.534 (3) |
C25A—H25A | 1.0000 | C23B—H23E | 0.9900 |
C23C—C24C | 1.511 (6) | C23B—H23F | 0.9900 |
C23C—H23C | 0.9900 | C24B—C25B | 1.529 (3) |
C23C—H23D | 0.9900 | C24B—H24E | 0.9900 |
C24C—C25C | 1.505 (6) | C24B—H24F | 0.9900 |
C24C—H24C | 0.9900 | C25B—C27B | 1.524 (4) |
C24C—H24D | 0.9900 | C25B—C26B | 1.527 (3) |
C25C—C27A | 1.548 (6) | C25B—H25B | 1.0000 |
C25C—C26A | 1.618 (6) | C26B—H26A | 0.9800 |
C25C—H25C | 1.0000 | C26B—H26B | 0.9800 |
C26A—H26D | 0.9758 | C26B—H26C | 0.9800 |
C26A—H26E | 0.9658 | C27B—H27A | 0.9800 |
C26A—H26F | 0.9514 | C27B—H27B | 0.9800 |
C26A—H26G | 0.9625 | C27B—H27C | 0.9800 |
N1A—O1A—H1A | 96 (2) | C25C—C26A—H26I | 110.3 |
N1A—C1A—C17A | 126.0 (2) | H26D—C26A—H26I | 48.9 |
N1A—C1A—C2A | 118.2 (2) | H26E—C26A—H26I | 90.9 |
C17A—C1A—C2A | 115.76 (19) | H26F—C26A—H26I | 154.8 |
C1A—N1A—O1A | 113.69 (19) | H26G—C26A—H26I | 107.7 |
C1A—C2A—C3A | 114.6 (2) | H26H—C26A—H26I | 108.6 |
C1A—C2A—C7A | 110.2 (2) | C25C—C27A—H27D | 139.1 |
C3A—C2A—C7A | 114.0 (2) | C25A—C27A—H27D | 111.2 |
C1A—C2A—H2A | 105.7 | C25C—C27A—H27E | 77.5 |
C3A—C2A—H2A | 105.7 | C25A—C27A—H27E | 110.5 |
C7A—C2A—H2A | 105.7 | H27D—C27A—H27E | 108.7 |
C4A—C3A—C2A | 110.5 (2) | C25C—C27A—H27F | 107.4 |
C4A—C3A—H3A1 | 109.6 | C25A—C27A—H27F | 109.3 |
C2A—C3A—H3A1 | 109.6 | H27D—C27A—H27F | 108.4 |
C4A—C3A—H3A2 | 109.6 | H27E—C27A—H27F | 108.7 |
C2A—C3A—H3A2 | 109.6 | C25C—C27A—H27G | 110.6 |
H3A1—C3A—H3A2 | 108.1 | C25A—C27A—H27G | 124.9 |
C5A—C4A—C3A | 110.6 (3) | H27D—C27A—H27G | 109.9 |
C5A—C4A—H4A1 | 109.5 | H27E—C27A—H27G | 88.8 |
C3A—C4A—H4A1 | 109.5 | C25C—C27A—H27H | 109.9 |
C5A—C4A—H4A2 | 109.5 | C25A—C27A—H27H | 73.5 |
C3A—C4A—H4A2 | 109.5 | H27D—C27A—H27H | 50.3 |
H4A1—C4A—H4A2 | 108.1 | H27E—C27A—H27H | 155.8 |
C4A—C5A—C6A | 111.9 (2) | H27F—C27A—H27H | 91.4 |
C4A—C5A—H5A1 | 109.2 | H27G—C27A—H27H | 108.8 |
C6A—C5A—H5A1 | 109.2 | C25C—C27A—H27I | 108.7 |
C4A—C5A—H5A2 | 109.2 | C25A—C27A—H27I | 121.7 |
C6A—C5A—H5A2 | 109.2 | H27D—C27A—H27I | 61.5 |
H5A1—C5A—H5A2 | 107.9 | H27E—C27A—H27I | 47.6 |
C5A—C6A—C7A | 113.8 (2) | H27F—C27A—H27I | 128.3 |
C5A—C6A—H6A1 | 108.8 | H27G—C27A—H27I | 109.5 |
C7A—C6A—H6A1 | 108.8 | H27H—C27A—H27I | 109.2 |
C5A—C6A—H6A2 | 108.8 | N1B—O1B—H1B | 100 (2) |
C7A—C6A—H6A2 | 108.8 | N1B—C1B—C2B | 118.5 (2) |
H6A1—C6A—H6A2 | 107.7 | N1B—C1B—C17B | 126.6 (2) |
C18A—C7A—C6A | 110.1 (2) | C2B—C1B—C17B | 114.83 (19) |
C18A—C7A—C8A | 111.4 (2) | C1B—N1B—O1B | 113.34 (19) |
C6A—C7A—C8A | 109.87 (19) | C1B—C2B—C3B | 114.90 (18) |
C18A—C7A—C2A | 110.3 (2) | C1B—C2B—C7B | 109.72 (18) |
C6A—C7A—C2A | 108.0 (2) | C3B—C2B—C7B | 113.36 (19) |
C8A—C7A—C2A | 107.09 (18) | C1B—C2B—H2B | 106.0 |
C16A—C8A—C9A | 109.79 (19) | C3B—C2B—H2B | 106.0 |
C16A—C8A—C7A | 112.80 (18) | C7B—C2B—H2B | 106.0 |
C9A—C8A—C7A | 115.4 (2) | C4B—C3B—C2B | 110.39 (19) |
C16A—C8A—H8A | 106.0 | C4B—C3B—H3B1 | 109.6 |
C9A—C8A—H8A | 106.0 | C2B—C3B—H3B1 | 109.6 |
C7A—C8A—H8A | 106.0 | C4B—C3B—H3B2 | 109.6 |
C10A—C9A—C8A | 113.1 (2) | C2B—C3B—H3B2 | 109.6 |
C10A—C9A—H9A1 | 109.0 | H3B1—C3B—H3B2 | 108.1 |
C8A—C9A—H9A1 | 109.0 | C3B—C4B—C5B | 110.9 (2) |
C10A—C9A—H9A2 | 109.0 | C3B—C4B—H4B1 | 109.5 |
C8A—C9A—H9A2 | 109.0 | C5B—C4B—H4B1 | 109.5 |
H9A1—C9A—H9A2 | 107.8 | C3B—C4B—H4B2 | 109.5 |
C9A—C10A—C11A | 112.7 (2) | C5B—C4B—H4B2 | 109.5 |
C9A—C10A—H10A | 109.0 | H4B1—C4B—H4B2 | 108.1 |
C11A—C10A—H10A | 109.0 | C4B—C5B—C6B | 111.6 (2) |
C9A—C10A—H10B | 109.0 | C4B—C5B—H5B1 | 109.3 |
C11A—C10A—H10B | 109.0 | C6B—C5B—H5B1 | 109.3 |
H10A—C10A—H10B | 107.8 | C4B—C5B—H5B2 | 109.3 |
C10A—C11A—C19A | 110.5 (2) | C6B—C5B—H5B2 | 109.3 |
C10A—C11A—C15A | 107.43 (19) | H5B1—C5B—H5B2 | 108.0 |
C19A—C11A—C15A | 112.08 (19) | C5B—C6B—C7B | 113.79 (19) |
C10A—C11A—C12A | 117.5 (2) | C5B—C6B—H6B1 | 108.8 |
C19A—C11A—C12A | 110.1 (2) | C7B—C6B—H6B1 | 108.8 |
C15A—C11A—C12A | 98.66 (19) | C5B—C6B—H6B2 | 108.8 |
C20A—C12A—C11A | 120.5 (2) | C7B—C6B—H6B2 | 108.8 |
C20A—C12A—C13A | 112.1 (2) | H6B1—C6B—H6B2 | 107.7 |
C11A—C12A—C13A | 103.23 (19) | C18B—C7B—C6B | 110.33 (19) |
C20A—C12A—H12A | 106.7 | C18B—C7B—C8B | 111.22 (19) |
C11A—C12A—H12A | 106.7 | C6B—C7B—C8B | 109.98 (18) |
C13A—C12A—H12A | 106.7 | C18B—C7B—C2B | 110.54 (18) |
C14A—C13A—C12A | 106.6 (2) | C6B—C7B—C2B | 106.90 (19) |
C14A—C13A—H13A | 110.4 | C8B—C7B—C2B | 107.74 (17) |
C12A—C13A—H13A | 110.4 | C9B—C8B—C16B | 110.23 (18) |
C14A—C13A—H13B | 110.4 | C9B—C8B—C7B | 113.48 (18) |
C12A—C13A—H13B | 110.4 | C16B—C8B—C7B | 113.20 (17) |
H13A—C13A—H13B | 108.6 | C9B—C8B—H8B | 106.5 |
C15A—C14A—C13A | 103.35 (18) | C16B—C8B—H8B | 106.5 |
C15A—C14A—H14A | 111.1 | C7B—C8B—H8B | 106.5 |
C13A—C14A—H14A | 111.1 | C8B—C9B—C10B | 113.74 (19) |
C15A—C14A—H14B | 111.1 | C8B—C9B—H9B1 | 108.8 |
C13A—C14A—H14B | 111.1 | C10B—C9B—H9B1 | 108.8 |
H14A—C14A—H14B | 109.1 | C8B—C9B—H9B2 | 108.8 |
C16A—C15A—C14A | 119.35 (19) | C10B—C9B—H9B2 | 108.8 |
C16A—C15A—C11A | 114.9 (2) | H9B1—C9B—H9B2 | 107.7 |
C14A—C15A—C11A | 104.40 (18) | C11B—C10B—C9B | 112.10 (18) |
C16A—C15A—H15A | 105.7 | C11B—C10B—H10C | 109.2 |
C14A—C15A—H15A | 105.7 | C9B—C10B—H10C | 109.2 |
C11A—C15A—H15A | 105.7 | C11B—C10B—H10D | 109.2 |
C15A—C16A—C8A | 108.72 (18) | C9B—C10B—H10D | 109.2 |
C15A—C16A—C17A | 109.77 (19) | H10C—C10B—H10D | 107.9 |
C8A—C16A—C17A | 111.73 (19) | C10B—C11B—C19B | 111.40 (19) |
C15A—C16A—H16A | 108.9 | C10B—C11B—C15B | 106.94 (18) |
C8A—C16A—H16A | 108.9 | C19B—C11B—C15B | 111.59 (18) |
C17A—C16A—H16A | 108.9 | C10B—C11B—C12B | 116.93 (18) |
C1A—C17A—C16A | 113.28 (19) | C19B—C11B—C12B | 109.29 (19) |
C1A—C17A—H17A | 108.9 | C15B—C11B—C12B | 100.14 (17) |
C16A—C17A—H17A | 108.9 | C20B—C12B—C11B | 118.77 (19) |
C1A—C17A—H17B | 108.9 | C20B—C12B—C13B | 111.80 (18) |
C16A—C17A—H17B | 108.9 | C11B—C12B—C13B | 102.94 (17) |
H17A—C17A—H17B | 107.7 | C20B—C12B—H12B | 107.6 |
C7A—C18A—H18A | 109.5 | C11B—C12B—H12B | 107.6 |
C7A—C18A—H18B | 109.5 | C13B—C12B—H12B | 107.6 |
H18A—C18A—H18B | 109.5 | C14B—C13B—C12B | 106.93 (18) |
C7A—C18A—H18C | 109.5 | C14B—C13B—H13C | 110.3 |
H18A—C18A—H18C | 109.5 | C12B—C13B—H13C | 110.3 |
H18B—C18A—H18C | 109.5 | C14B—C13B—H13D | 110.3 |
C11A—C19A—H19A | 109.5 | C12B—C13B—H13D | 110.3 |
C11A—C19A—H19B | 109.5 | H13C—C13B—H13D | 108.6 |
H19A—C19A—H19B | 109.5 | C15B—C14B—C13B | 104.03 (18) |
C11A—C19A—H19C | 109.5 | C15B—C14B—H14C | 111.0 |
H19A—C19A—H19C | 109.5 | C13B—C14B—H14C | 111.0 |
H19B—C19A—H19C | 109.5 | C15B—C14B—H14D | 111.0 |
C21A—C20A—C22A | 110.9 (2) | C13B—C14B—H14D | 111.0 |
C21A—C20A—C12A | 111.5 (2) | H14C—C14B—H14D | 109.0 |
C22A—C20A—C12A | 109.1 (2) | C14B—C15B—C16B | 118.65 (18) |
C21A—C20A—H20A | 108.4 | C14B—C15B—C11B | 104.42 (17) |
C22A—C20A—H20A | 108.4 | C16B—C15B—C11B | 112.97 (18) |
C12A—C20A—H20A | 108.4 | C14B—C15B—H15B | 106.7 |
C20A—C21A—H21A | 109.5 | C16B—C15B—H15B | 106.7 |
C20A—C21A—H21B | 109.5 | C11B—C15B—H15B | 106.7 |
H21A—C21A—H21B | 109.5 | C15B—C16B—C17B | 111.56 (18) |
C20A—C21A—H21C | 109.5 | C15B—C16B—C8B | 108.96 (17) |
H21A—C21A—H21C | 109.5 | C17B—C16B—C8B | 111.85 (18) |
H21B—C21A—H21C | 109.5 | C15B—C16B—H16B | 108.1 |
C23C—C22A—C20A | 113.8 (3) | C17B—C16B—H16B | 108.1 |
C20A—C22A—C23A | 118.2 (3) | C8B—C16B—H16B | 108.1 |
C23C—C22A—H22A | 84.1 | C1B—C17B—C16B | 109.29 (18) |
C20A—C22A—H22A | 107.8 | C1B—C17B—H17C | 109.8 |
C23A—C22A—H22A | 107.8 | C16B—C17B—H17C | 109.8 |
C23C—C22A—H22B | 131.0 | C1B—C17B—H17D | 109.8 |
C20A—C22A—H22B | 107.8 | C16B—C17B—H17D | 109.8 |
C23A—C22A—H22B | 107.8 | H17C—C17B—H17D | 108.3 |
H22A—C22A—H22B | 107.1 | C7B—C18B—H18D | 109.5 |
C24A—C23A—C22A | 125.9 (6) | C7B—C18B—H18E | 109.5 |
C24A—C23A—H23A | 105.8 | H18D—C18B—H18E | 109.5 |
C22A—C23A—H23A | 105.8 | C7B—C18B—H18F | 109.5 |
C24A—C23A—H23B | 105.8 | H18D—C18B—H18F | 109.5 |
C22A—C23A—H23B | 105.8 | H18E—C18B—H18F | 109.5 |
H23A—C23A—H23B | 106.2 | C11B—C19B—H19D | 109.5 |
C23A—C24A—C25A | 116.9 (6) | C11B—C19B—H19E | 109.5 |
C23A—C24A—H24A | 108.1 | H19D—C19B—H19E | 109.5 |
C25A—C24A—H24A | 108.1 | C11B—C19B—H19F | 109.5 |
C23A—C24A—H24B | 108.1 | H19D—C19B—H19F | 109.5 |
C25A—C24A—H24B | 108.1 | H19E—C19B—H19F | 109.5 |
H24A—C24A—H24B | 107.3 | C21B—C20B—C22B | 109.9 (2) |
C26A—C25A—C27A | 108.5 (3) | C21B—C20B—C12B | 112.52 (19) |
C26A—C25A—C24A | 100.3 (5) | C22B—C20B—C12B | 111.13 (19) |
C27A—C25A—C24A | 100.7 (4) | C21B—C20B—H20B | 107.7 |
C26A—C25A—H25A | 115.1 | C22B—C20B—H20B | 107.7 |
C27A—C25A—H25A | 115.1 | C12B—C20B—H20B | 107.7 |
C24A—C25A—H25A | 115.1 | C20B—C21B—H21D | 109.5 |
C27A—C25A—H26I | 117.5 | C20B—C21B—H21E | 109.5 |
C24A—C25A—H26I | 128.6 | H21D—C21B—H21E | 109.5 |
H25A—C25A—H26I | 79.4 | C20B—C21B—H21F | 109.5 |
C22A—C23C—C24C | 108.8 (4) | H21D—C21B—H21F | 109.5 |
C22A—C23C—H23C | 109.9 | H21E—C21B—H21F | 109.5 |
C24C—C23C—H23C | 109.9 | C23B—C22B—C20B | 112.4 (2) |
C22A—C23C—H23D | 109.9 | C23B—C22B—H22C | 109.1 |
C24C—C23C—H23D | 109.9 | C20B—C22B—H22C | 109.1 |
H23C—C23C—H23D | 108.3 | C23B—C22B—H22D | 109.1 |
C25C—C24C—C23C | 122.0 (4) | C20B—C22B—H22D | 109.1 |
C25C—C24C—H24C | 106.8 | H22C—C22B—H22D | 107.8 |
C23C—C24C—H24C | 106.8 | C24B—C23B—C22B | 116.7 (2) |
C25C—C24C—H24D | 106.8 | C24B—C23B—H23E | 108.1 |
C23C—C24C—H24D | 106.8 | C22B—C23B—H23E | 108.1 |
H24C—C24C—H24D | 106.7 | C24B—C23B—H23F | 108.1 |
C24C—C25C—C27A | 108.1 (4) | C22B—C23B—H23F | 108.1 |
C24C—C25C—C26A | 109.9 (4) | H23E—C23B—H23F | 107.3 |
C27A—C25C—C26A | 104.2 (3) | C25B—C24B—C23B | 116.1 (2) |
C24C—C25C—H25C | 111.4 | C25B—C24B—H24E | 108.3 |
C27A—C25C—H25C | 111.4 | C23B—C24B—H24E | 108.3 |
C26A—C25C—H25C | 111.4 | C25B—C24B—H24F | 108.3 |
C25A—C26A—H26D | 110.2 | C23B—C24B—H24F | 108.3 |
C25C—C26A—H26D | 135.7 | H24E—C24B—H24F | 107.4 |
C25A—C26A—H26E | 109.9 | C27B—C25B—C26B | 110.4 (2) |
C25C—C26A—H26E | 111.5 | C27B—C25B—C24B | 112.4 (2) |
H26D—C26A—H26E | 107.7 | C26B—C25B—C24B | 110.4 (2) |
C25A—C26A—H26F | 110.4 | C27B—C25B—H25B | 107.8 |
C25C—C26A—H26F | 76.3 | C26B—C25B—H25B | 107.8 |
H26D—C26A—H26F | 108.9 | C24B—C25B—H25B | 107.8 |
H26E—C26A—H26F | 109.7 | C25B—C26B—H26A | 109.5 |
C25A—C26A—H26G | 120.6 | C25B—C26B—H26B | 109.5 |
C25C—C26A—H26G | 110.4 | H26A—C26B—H26B | 109.5 |
H26D—C26A—H26G | 113.3 | C25B—C26B—H26C | 109.5 |
H26F—C26A—H26G | 91.6 | H26A—C26B—H26C | 109.5 |
C25A—C26A—H26H | 126.2 | H26B—C26B—H26C | 109.5 |
C25C—C26A—H26H | 110.0 | C25B—C27B—H27A | 109.5 |
H26D—C26A—H26H | 60.9 | C25B—C27B—H27B | 109.5 |
H26E—C26A—H26H | 123.5 | H27A—C27B—H27B | 109.5 |
H26F—C26A—H26H | 48.0 | C25B—C27B—H27C | 109.5 |
H26G—C26A—H26H | 109.8 | H27A—C27B—H27C | 109.5 |
C25A—C26A—H26I | 74.0 | H27B—C27B—H27C | 109.5 |
C17A—C1A—N1A—O1A | 1.6 (3) | C27A—C25A—C26A—C25C | −64.1 (4) |
C2A—C1A—N1A—O1A | 178.6 (2) | C24A—C25A—C26A—C25C | 41.1 (4) |
N1A—C1A—C2A—C3A | −2.9 (3) | C24C—C25C—C26A—C25A | −51.6 (4) |
C17A—C1A—C2A—C3A | 174.4 (2) | C27A—C25C—C26A—C25A | 64.0 (4) |
N1A—C1A—C2A—C7A | 127.3 (2) | C24C—C25C—C27A—C25A | 58.9 (4) |
C17A—C1A—C2A—C7A | −55.4 (3) | C26A—C25C—C27A—C25A | −58.0 (4) |
C1A—C2A—C3A—C4A | −175.2 (2) | C26A—C25A—C27A—C25C | 69.9 (4) |
C7A—C2A—C3A—C4A | 56.6 (3) | C24A—C25A—C27A—C25C | −34.9 (5) |
C2A—C3A—C4A—C5A | −57.0 (3) | C2B—C1B—N1B—O1B | −179.16 (19) |
C3A—C4A—C5A—C6A | 56.6 (3) | C17B—C1B—N1B—O1B | −2.4 (3) |
C4A—C5A—C6A—C7A | −55.2 (3) | N1B—C1B—C2B—C3B | −12.9 (3) |
C5A—C6A—C7A—C18A | −69.5 (3) | C17B—C1B—C2B—C3B | 169.95 (19) |
C5A—C6A—C7A—C8A | 167.4 (2) | N1B—C1B—C2B—C7B | 116.2 (2) |
C5A—C6A—C7A—C2A | 51.0 (3) | C17B—C1B—C2B—C7B | −60.9 (2) |
C1A—C2A—C7A—C18A | −62.4 (3) | C1B—C2B—C3B—C4B | −174.5 (2) |
C3A—C2A—C7A—C18A | 68.1 (3) | C7B—C2B—C3B—C4B | 58.2 (3) |
C1A—C2A—C7A—C6A | 177.30 (19) | C2B—C3B—C4B—C5B | −56.1 (3) |
C3A—C2A—C7A—C6A | −52.3 (3) | C3B—C4B—C5B—C6B | 54.9 (3) |
C1A—C2A—C7A—C8A | 59.0 (2) | C4B—C5B—C6B—C7B | −55.6 (3) |
C3A—C2A—C7A—C8A | −170.53 (19) | C5B—C6B—C7B—C18B | −66.5 (3) |
C18A—C7A—C8A—C16A | 61.3 (2) | C5B—C6B—C7B—C8B | 170.40 (19) |
C6A—C7A—C8A—C16A | −176.5 (2) | C5B—C6B—C7B—C2B | 53.7 (3) |
C2A—C7A—C8A—C16A | −59.5 (2) | C1B—C2B—C7B—C18B | −65.2 (2) |
C18A—C7A—C8A—C9A | −66.1 (3) | C3B—C2B—C7B—C18B | 64.7 (2) |
C6A—C7A—C8A—C9A | 56.2 (3) | C1B—C2B—C7B—C6B | 174.70 (18) |
C2A—C7A—C8A—C9A | 173.19 (19) | C3B—C2B—C7B—C6B | −55.4 (2) |
C16A—C8A—C9A—C10A | 55.5 (3) | C1B—C2B—C7B—C8B | 56.5 (2) |
C7A—C8A—C9A—C10A | −175.6 (2) | C3B—C2B—C7B—C8B | −173.54 (18) |
C8A—C9A—C10A—C11A | −55.1 (3) | C18B—C7B—C8B—C9B | −59.9 (2) |
C9A—C10A—C11A—C19A | −70.1 (3) | C6B—C7B—C8B—C9B | 62.6 (2) |
C9A—C10A—C11A—C15A | 52.5 (3) | C2B—C7B—C8B—C9B | 178.76 (18) |
C9A—C10A—C11A—C12A | 162.4 (2) | C18B—C7B—C8B—C16B | 66.7 (2) |
C10A—C11A—C12A—C20A | 76.5 (3) | C6B—C7B—C8B—C16B | −170.81 (19) |
C19A—C11A—C12A—C20A | −51.2 (3) | C2B—C7B—C8B—C16B | −54.6 (2) |
C15A—C11A—C12A—C20A | −168.6 (2) | C16B—C8B—C9B—C10B | 52.2 (2) |
C10A—C11A—C12A—C13A | −157.6 (2) | C7B—C8B—C9B—C10B | −179.69 (19) |
C19A—C11A—C12A—C13A | 74.8 (2) | C8B—C9B—C10B—C11B | −53.8 (3) |
C15A—C11A—C12A—C13A | −42.7 (2) | C9B—C10B—C11B—C19B | −66.9 (2) |
C20A—C12A—C13A—C14A | 154.2 (2) | C9B—C10B—C11B—C15B | 55.2 (2) |
C11A—C12A—C13A—C14A | 23.0 (2) | C9B—C10B—C11B—C12B | 166.40 (19) |
C12A—C13A—C14A—C15A | 6.7 (3) | C10B—C11B—C12B—C20B | 80.1 (3) |
C13A—C14A—C15A—C16A | −164.5 (2) | C19B—C11B—C12B—C20B | −47.6 (3) |
C13A—C14A—C15A—C11A | −34.4 (2) | C15B—C11B—C12B—C20B | −164.89 (19) |
C10A—C11A—C15A—C16A | −56.6 (3) | C10B—C11B—C12B—C13B | −155.79 (19) |
C19A—C11A—C15A—C16A | 65.0 (3) | C19B—C11B—C12B—C13B | 76.5 (2) |
C12A—C11A—C15A—C16A | −179.06 (19) | C15B—C11B—C12B—C13B | −40.8 (2) |
C10A—C11A—C15A—C14A | 170.8 (2) | C20B—C12B—C13B—C14B | 150.24 (19) |
C19A—C11A—C15A—C14A | −67.6 (3) | C11B—C12B—C13B—C14B | 21.6 (2) |
C12A—C11A—C15A—C14A | 48.3 (2) | C12B—C13B—C14B—C15B | 6.7 (2) |
C14A—C15A—C16A—C8A | −175.63 (19) | C13B—C14B—C15B—C16B | −159.81 (19) |
C11A—C15A—C16A—C8A | 59.2 (2) | C13B—C14B—C15B—C11B | −33.0 (2) |
C14A—C15A—C16A—C17A | −53.1 (3) | C10B—C11B—C15B—C14B | 168.70 (18) |
C11A—C15A—C16A—C17A | −178.32 (19) | C19B—C11B—C15B—C14B | −69.3 (2) |
C9A—C8A—C16A—C15A | −55.6 (2) | C12B—C11B—C15B—C14B | 46.3 (2) |
C7A—C8A—C16A—C15A | 174.08 (19) | C10B—C11B—C15B—C16B | −61.0 (2) |
C9A—C8A—C16A—C17A | −176.9 (2) | C19B—C11B—C15B—C16B | 61.0 (2) |
C7A—C8A—C16A—C17A | 52.8 (3) | C12B—C11B—C15B—C16B | 176.61 (18) |
N1A—C1A—C17A—C16A | −135.3 (2) | C14B—C15B—C16B—C17B | −51.9 (3) |
C2A—C1A—C17A—C16A | 47.7 (3) | C11B—C15B—C16B—C17B | −174.53 (18) |
C15A—C16A—C17A—C1A | −165.31 (19) | C14B—C15B—C16B—C8B | −175.85 (19) |
C8A—C16A—C17A—C1A | −44.6 (3) | C11B—C15B—C16B—C8B | 61.5 (2) |
C11A—C12A—C20A—C21A | −55.6 (3) | C9B—C8B—C16B—C15B | −54.5 (2) |
C13A—C12A—C20A—C21A | −177.4 (2) | C7B—C8B—C16B—C15B | 177.24 (17) |
C11A—C12A—C20A—C22A | −178.5 (2) | C9B—C8B—C16B—C17B | −178.27 (19) |
C13A—C12A—C20A—C22A | 59.8 (3) | C7B—C8B—C16B—C17B | 53.4 (2) |
C21A—C20A—C22A—C23C | 48.0 (4) | N1B—C1B—C17B—C16B | −119.6 (3) |
C12A—C20A—C22A—C23C | 171.2 (3) | C2B—C1B—C17B—C16B | 57.2 (3) |
C21A—C20A—C22A—C23A | 79.0 (4) | C15B—C16B—C17B—C1B | −173.77 (18) |
C12A—C20A—C22A—C23A | −157.8 (3) | C8B—C16B—C17B—C1B | −51.4 (2) |
C23C—C22A—C23A—C24A | −82.6 (9) | C11B—C12B—C20B—C21B | −55.1 (3) |
C20A—C22A—C23A—C24A | −170.8 (5) | C13B—C12B—C20B—C21B | −174.8 (2) |
C22A—C23A—C24A—C25A | 90.4 (8) | C11B—C12B—C20B—C22B | −178.8 (2) |
C23A—C24A—C25A—C26A | 78.9 (7) | C13B—C12B—C20B—C22B | 61.5 (2) |
C23A—C24A—C25A—C27A | −169.8 (6) | C21B—C20B—C22B—C23B | 73.3 (3) |
C20A—C22A—C23C—C24C | −177.1 (3) | C12B—C20B—C22B—C23B | −161.5 (2) |
C23A—C22A—C23C—C24C | 77.1 (7) | C20B—C22B—C23B—C24B | −171.1 (2) |
C22A—C23C—C24C—C25C | −156.5 (4) | C22B—C23B—C24B—C25B | 91.1 (3) |
C23C—C24C—C25C—C27A | −151.5 (4) | C23B—C24B—C25B—C27B | −71.7 (3) |
C23C—C24C—C25C—C26A | −38.4 (6) | C23B—C24B—C25B—C26B | 164.5 (2) |
Experimental details
Crystal data | |
Chemical formula | C27H47NO |
Mr | 401.65 |
Crystal system, space group | Monoclinic, P21 |
Temperature (K) | 100 |
a, b, c (Å) | 13.7535 (7), 9.5266 (4), 18.681 (1) |
β (°) | 102.829 (3) |
V (Å3) | 2386.6 (2) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.07 |
Crystal size (mm) | 0.54 × 0.31 × 0.17 |
Data collection | |
Diffractometer | Bruker Kappa APEXII Duo |
Absorption correction | Multi-scan (Blessing, 1995) |
Tmin, Tmax | 0.965, 0.989 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 51587, 7706, 6021 |
Rint | 0.052 |
(sin θ/λ)max (Å−1) | 0.716 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.049, 0.129, 1.12 |
No. of reflections | 7706 |
No. of parameters | 564 |
No. of restraints | 59 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.48, −0.32 |
Computer programs: APEX2 (Bruker, 2008), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), ORTEP-3 (Farrugia, 1997), publCIF (Westrip, 2010).
Acknowledgements
SU, HK and AM thank the Department of Chemistry, Aligarth Muslim University, India, for providing the necessary research facilities. YNM thanks the Deanship of Scientific Research at King Saud University for funding this work through Research Group Project No. RGP-VPP-007. Thanks are extended to Dr Wolfgang Frey, Institut für Organische Chemie, Universität Stuttgart, Germany, for valuable help.
References
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This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
Steroids are compounds of biological origin and play an important role in biological systems. The dramatic expansion of steroidal chemistry came with the discovery of steroidal hormones. The discovery of several steroids with their wide application in therapy has brought about an increasing interest (Grover et al., 2007). A series of crystal structures of hydroxyiminocholestane (Ketuly et al., 2011) and derivatives of cholesterol (Park, 2004) have been examined in order to obtain structural information relevant to the liquid crystalline phases and the possible modes of association of the cholesterol derivatives themselves.
In the view of the biological importance of cholesterol derivatives, we report here the crystal structure of the title compound (I). There are two molecules in the asymmetric unit (Fig. 1), while unit cell contains 4 molecules (Fig. 2). The ring bond lengths have normal values (Allen et al., 1987) with average C(sp3)—C(sp3) of 1.533 (2) Å, excluding the shorter C1—C62 bond of 1.496 (2) Å. The cholestane side-chain shows C(sp3)—C(sp3) bond lengths varying from C25—C26 [1.525 (2) Å] up to C20—C22 [1.539 (2) Å]. Each of the six-member rings adopts a chair conformation or close to a chair conformation, and the five-member ring has a twisted conformation. There are eight chiral centres in the molecule, the absolute configuration of these sites was determined from the structure presented, these sites exhibit the following chiralities: C2= S, C7 = R, C8 = S, C11 = R, C12 = R, C15 = S, C16 = S and C20 = R.