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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 68| Part 12| December 2012| Pages o3350-o3351
doi:10.1107/S1600536812046351

4-Meth­­oxy­benzamidinium hydrogen oxalate monohydrate

Simona Irreraa and Gustavo Portalonea*

aChemistry Department, "Sapienza" University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy
*Correspondence e-mail: g.portalone@caspur.it

(Received 6 November 2012; accepted 9 November 2012; online 14 November 2012)

The title hydrated salt, C8H11N2O+·C2HO4−·H2O, was synthesized by a reaction of 4-meth­oxy­benzamidine (4-amidino­anisole) and oxalic acid in water solution. In the cation, the amidinium group forms a dihedral angle of 15.60 (6)° with the mean plane of the benzene ring. In the crystal, each amidinium unit is bound to three acetate anions and one water mol­ecule by six distinct N—H⋯O hydrogen bonds. The ion pairs of the asymmetric unit are joined by two N—H⋯O hydrogen bonds into ionic dimers in which the carbonyl O atom of the semi-oxalate anion acts as a bifurcated acceptor, thus generating an R12(6) motif. These subunits are then joined through the remaining N—H⋯O hydrogen bonds to adjacent semi-oxalate anions into linear tetra­meric chains running approximately along the b axis. The structure is stabilized by N—H⋯O and O—H⋯O inter­molecular hydrogen bonds. The water mol­ecule plays an important role in the cohesion and the stability of the crystal structure being involved in three hydrogen bonds connecting two semi-oxalate anions as donor and a benzamidinium cation as acceptor.

Related literature

For the biological and pharmacological relevance of benzamidine, see: Powers & Harper (1999[Powers, J. C. & Harper, J. W. (1999). Proteinase inhibitors, edited by A. J. Barrett & G. Salvesen, pp. 55-152. Amsterdam: Elsevier.]). For structural analysis of proton-transfer adducts containing mol­ecules of biological inter­est, see: Portalone, (2011a[Portalone, G. (2011a). Chem. Centr. J. 5, 51.]); Portalone & Irrera (2011[Portalone, G. & Irrera, S. (2011). J. Mol. Struct. 991, 92-96.]). For supra­molecular association in proton-transfer adducts containing benzamidinium cations, see; Portalone (2010[Portalone, G. (2010). Acta Cryst. C66, o295-o301.], 2011b[Portalone, G. (2011b). Acta Cryst. E67, o3394-o3395.], 2012[Portalone, G. (2012). Acta Cryst. E68, o268-o269.]); Irrera et al. (2012[Irrera, S., Ortaggi, G. & Portalone, G. (2012). Acta Cryst. C68, o447-o451.]); Irrera & Portalone (2012a[Irrera, S. & Portalone, G. (2012a). Acta Cryst. E68, o3083.],b[Irrera, S. & Portalone, G. (2012b). Acta Cryst. E68, o3244.],c[Irrera, S. & Portalone, G. (2012c). Acta Cryst. E68, o3277.]). For hydrogen-bond motifs, see Bernstein et al. (1995[Bernstein, J., Davis, R. E., Shimoni, L. & Chang, N.-L. (1995). Angew. Chem. Int. Ed. Engl. 34, 1555-1573.]).

[Scheme 1]

Experimental

Crystal data

  • C8H11N2O+·C2HO4−·H2O

  • Mr = 258.23

  • Monoclinic, P 21 /c

  • a = 7.1444 (8) Å

  • b = 9.0428 (7) Å

  • c = 18.115 (2) Å

  • β = 93.156 (10)°

  • V = 1168.5 (2) Å3

  • Z = 4

  • Mo Kα radiation

  • μ = 0.12 mm−1

  • T = 298 K

  • 0.18 × 0.12 × 0.09 mm
Data collection

  • Oxford Diffraction Xcalibur S CCD diffractometer

  • Absorption correction: multi-scan (CrysAlis PRO; Agilent, 2011[Agilent (2011). CrysAlis PRO. Agilent Technologies, Yarnton, England.]) Tmin = 0.978, Tmax = 0.989

  • 15203 measured reflections

  • 2135 independent reflections

  • 1693 reflections with I > 2σ(I)

  • Rint = 0.046
Refinement

  • R[F2 > 2σ(F2)] = 0.047

  • wR(F2) = 0.110

  • S = 1.09

  • 2135 reflections

  • 201 parameters

  • 2 restraints

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.16 e Å−3

  • Δρmin = −0.15 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
N1—H1A⋯O3 0.92 (3) 2.43 (3) 3.180 (3) 138 (2)
N1—H1B⋯O2W 0.92 (2) 2.00 (2) 2.891 (3) 161 (2)
N1—H1A⋯O5i 0.92 (3) 2.37 (3) 3.096 (2) 135 (2)
N2—H2A⋯O3 0.86 (2) 2.05 (2) 2.869 (2) 159 (2)
N2—H2A⋯O4ii 0.86 (2) 2.34 (2) 2.827 (2) 116.4 (18)
N2—H2B⋯O6ii 0.88 (2) 2.09 (3) 2.932 (2) 159.5 (19)
O4—H4⋯O5i 1.02 (3) 1.56 (3) 2.5840 (19) 178 (2)
O2W—H21W⋯O5iii 0.85 (2) 2.15 (2) 2.976 (6) 163 (3)
O2W—H22W⋯O6i 0.88 (2) 1.97 (2) 2.853 (3) 177 (3)
Symmetry codes: (i) [-x+1, y-{\script{1\over 2}}, -z-{\script{1\over 2}}]; (ii) [-x+1, y+{\script{1\over 2}}, -z-{\script{1\over 2}}]; (iii) [x, -y-{\script{1\over 2}}, z+{\script{1\over 2}}].

Data collection: CrysAlis CCD (Oxford Diffraction, 2006[Oxford Diffraction (2006). CrysAlis CCD and CrysAlis RED. Oxford Diffraction Ltd, Yarnton, England.]); cell refinement: CrysAlis CCD; data reduction: CrysAlis RED (Oxford Diffraction, 2006[Oxford Diffraction (2006). CrysAlis CCD and CrysAlis RED. Oxford Diffraction Ltd, Yarnton, England.]); program(s) used to solve structure: SIR97 (Altomare et al., 1999[Altomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Polidori, G. & Spagna, R. (1999). J. Appl. Cryst. 32, 115-119.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: ORTEP-3 (Farrugia, 2012[Farrugia, L. J. (2012). J. Appl. Cryst. 45, 849-854.]); software used to prepare material for publication: WinGX (Farrugia, 2012[Farrugia, L. J. (2012). J. Appl. Cryst. 45, 849-854.]).

Supporting information

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536812046351/kp2440sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536812046351/kp2440Isup2.hkl

checkCIF report


Comment top

For some time now, we have studied proton-transfer adducts containing molecules of biological interest (Portalone, 2011a; Portalone & Irrera, 2011). In this context, benzamidine derivatives, which have shown strong biological and pharmacological activity (Powers & Harper, 1999), have been used in our group as bricks for supramolecular construction (Portalone, 2010, 2011b, 2012). Indeed, the bidentate hydrogen-bonding interaction between the amidinium and the carboxylate functional groups can be a powerful organizing force in solution and in the solid state.

The present study reports the single-crystal structure of the title molecular salt, 4-methoxybenzamidinium hydrogen oxalate monohydrate, (I), which was obtained by a reaction of 4-methoxybenzamidine (4-amidinoanisole) and oxalic acid in a water solution.

The asymmetric unit of the title compound comprises a non-planar 4-methoxybenzamidinium cation, a hydrogen oxalate anion and water molecule of crystallization (Fig. 1).

In the cation the amidinium group forms dihedral angle of 15.60 (6)° with the mean plane of the phenyl ring, which agrees with the values observed in protonated benzamidinium ions [14.4 (1) - 32.7 (1)°, Portalone, 2010, 2012; Irrera et al., 2012)]. The lack of planarity in all these systems is obviously caused by steric hindrances between the H atoms of the aromatic ring and the amidine moiety. This conformation is rather common in benzamidinium-containing small-molecule crystal structures, with the only exception of benzamidinium diliturate, where the benzamidinium cation is planar (Portalone, 2010). Geometrical parameters of the 4-methoxybenzamidinium cation agree with those reported in previous investigations of other similar structures (Irrera et al., 2012; Portalone, 2010, 2012; Irrera & Portalone, 2012a, 2012b, 2012c). In particular the amidinium group, true to one's expectations, features similar C—N bonds [1.317 (3) and 1.302 (2) Å], evidencing the delocalization of the π electrons and double-bond character.

The semi-oxalate anion is not planar, as the dihedral angle for the planes defined by the CO2H and CO2- non-H atoms is 14.1 (3)°. Bond distances around atom C10 indicate a carboxylate group with delocalization of the negative charge between atoms O5 and O6. Bond distances around atom C9 are consistent with a carboxylic acid group.

In the crystal structure of (I), (Fig. 2), the hydrogen-bonding scheme is rather complex. Each amidinium unit is bound to three acetate anions and one water molecule by six distinct N—H···O intermolecular hydrogen bonds (N···O = 2.827 (2) - 3.180 (3) Å, Table 1) into a one-dimensional structure. The ion pairs of the asymmetric unit are joined by two N—H···O hydrogen bonds in ionic dimers, where the carbonyl atom O3 of the semi-oxalate anion acts as a bifurcated acceptor, thus generating an R12(6) motif (Bernstein et al., 1995). These subunits are then joined through the remaining N—H···O hydrogen bonds to adjacent semi-oxalate anions into linear tetrameric chains running approximately along crystallographic b axis.

Water molecule plays an important role in the cohesion and the stability of the crystal structure: they are involved in three hydrogen bonds connecting two semi-oxalate anions as donor (O2W—H21W···O5 and O2W—H22W···O6) and a benzamidinium cation as acceptor O2W···H1B—N1 (Table 1).

Related literature top

For the biological and pharmacological relevance of benzamidine, see: Powers & Harper (1999). For structural analysis of proton-transfer adducts containing molecules of biological interest, see: Portalone, (2011a); Portalone & Irrera (2011). For supramolecular association in proton-transfer adducts containing benzamidinium cations, see; Portalone (2010, 2011b, 2012); Irrera et al. (2012); Irrera & Portalone (2012a,b,c). For hydrogen-bond motifs, see Bernstein et al. (1995).

Experimental top

4-Methoxybenzamidine (0.01 mmol, Fluka at 96% purity) was dissolved without further purification in 6 mL of a hot aqueous solution of oxalic acid (0.01 mmol, Aldrich at 99.99% purity) and heated under reflux for 3 h. After cooling the solution to an ambient temperature, colourless crystals suitable for single-crystal X-ray diffraction separated from the solution after a week.

Refinement top

All H atoms were identified in difference Fourier maps, but for refinement all C-bound H atoms were placed in calculated positions, with C—H = 0.93 Å (phenyl) and 0.97 Å (methyl), and refined as riding on their carrier atoms. The Uiso values were kept equal to 1.2Ueq(C, phenyl). and to 1.5Ueq(C, methyl). Positional and thermal parameters of H atoms of the amidinium and the carboxylic groups were refined, giving N—H distances in the range 0.86 (2) - 0.92 (3) Å, and O—H distance equal to 1.02 (3) Å. The water molecule is disordered over two sites, O2W and O21W. Their occupancies were refined to to 0.85 (2) and 0.15 (2), respectively, by imposing that their values must add up to precisely one. The O—H distances of the H atoms attached to O2W were restrained to 0.85 (2) - 0.88 (2) Å.

Computing details top

Data collection: CrysAlis CCD (Oxford Diffraction, 2006); cell refinement: CrysAlis CCD (Oxford Diffraction, 2006); data reduction: CrysAlis RED (Oxford Diffraction, 2006); program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 2012); software used to prepare material for publication: WinGX (Farrugia, 2012).

Figures top
[Figure 1] Fig. 1. The asymmetric unit of (I), showing the atom-labelling scheme. Displacements ellipsoids are at the 50% probability level. The major occupied site of the disordered water molecule is shown, only. H atoms are shown as small spheres of arbitrary radii. Hydrogen bonding is indicated by dashed lines.
[Figure 2] Fig. 2. Crystal packing diagram for (I), viewed approximately down a. All atoms are shown as small spheres of arbitrary radii. For the sake of clarity, only the major occupied site of the disordered water molecule and H atoms involved in hydrogen bonding are shown. Hydrogen bonding is indicated by dashed lines.
4-Methoxybenzamidinium hydrogen oxalate monohydrate top
Crystal data top
C8H11N2O+·C2HO4−·H2OF(000) = 544
Mr = 258.23Dx = 1.468 Mg m−3
Monoclinic, P21/cMo Kα radiation, λ = 0.71069 Å
Hall symbol: -P 2ybcCell parameters from 4235 reflections
a = 7.1444 (8) Åθ = 3.0–29.1°
b = 9.0428 (7) ŵ = 0.12 mm−1
c = 18.115 (2) ÅT = 298 K
β = 93.156 (10)°Tablets, colourless
V = 1168.5 (2) Å30.18 × 0.12 × 0.09 mm
Z = 4
Data collection top
Oxford Diffraction Xcalibur S CCD
diffractometer		2135 independent reflections
Radiation source: Enhance (Mo) X-ray Source1693 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.046
Detector resolution: 16.0696 pixels mm-1θmax = 25.4°, θmin = 3.2°
ω and ϕ scansh = −8→8
Absorption correction: multi-scan
(CrysAlis PRO; Agilent, 2011)		k = −10→10
Tmin = 0.978, Tmax = 0.989l = −21→21
15203 measured reflections
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.047Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.110H atoms treated by a mixture of independent and constrained refinement
S = 1.09 w = 1/[σ2(Fo2) + (0.0502P)2 + 0.2028P]
where P = (Fo2 + 2Fc2)/3
2135 reflections(Δ/σ)max < 0.001
201 parametersΔρmax = 0.16 e Å−3
2 restraintsΔρmin = −0.15 e Å−3
Crystal data top
C8H11N2O+·C2HO4−·H2OV = 1168.5 (2) Å3
Mr = 258.23Z = 4
Monoclinic, P21/cMo Kα radiation
a = 7.1444 (8) ŵ = 0.12 mm−1
b = 9.0428 (7) ÅT = 298 K
c = 18.115 (2) Å0.18 × 0.12 × 0.09 mm
β = 93.156 (10)°
Data collection top
Oxford Diffraction Xcalibur S CCD
diffractometer		2135 independent reflections
Absorption correction: multi-scan
(CrysAlis PRO; Agilent, 2011)		1693 reflections with I > 2σ(I)
Tmin = 0.978, Tmax = 0.989Rint = 0.046
15203 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0472 restraints
wR(F2) = 0.110H atoms treated by a mixture of independent and constrained refinement
S = 1.09Δρmax = 0.16 e Å−3
2135 reflectionsΔρmin = −0.15 e Å−3
201 parameters
Special details top

Experimental. Absorption correction: CrysAlisPro, Agilent Technologies, Version 1.171.35.19 (release 27-10-2011 CrysAlis171 .NET) (compiled Oct 27 2011,15:02:11) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm.

Geometry. All s.u.'s (except the s.u. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell s.u.'s are taken into account individually in the estimation of s.u.'s in distances, angles and torsion angles; correlations between s.u.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell s.u.'s is used for estimating s.u.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/UeqOcc. (<1)
O10.8980 (2)0.07501 (16)0.24710 (8)0.0511 (4)
N10.7104 (3)−0.2554 (2)−0.06019 (12)0.0484 (5)
H1A0.671 (4)−0.287 (3)−0.1070 (16)0.084 (9)*
H1B0.728 (3)−0.326 (3)−0.0238 (13)0.060 (7)*
N20.6975 (3)−0.0163 (2)−0.09613 (11)0.0439 (5)
H2A0.668 (3)−0.043 (2)−0.1409 (14)0.055 (7)*
H2B0.702 (3)0.080 (3)−0.0883 (12)0.053 (7)*
C10.7801 (2)−0.0672 (2)0.03205 (10)0.0327 (4)
C20.8530 (3)−0.1659 (2)0.08440 (11)0.0420 (5)
H20.8730−0.26350.07070.050*
C30.8970 (3)−0.1231 (2)0.15668 (11)0.0414 (5)
H30.9472−0.19080.19100.050*
C40.8654 (3)0.0217 (2)0.17730 (11)0.0371 (5)
C50.7954 (3)0.1222 (2)0.12537 (11)0.0440 (5)
H50.77610.21990.13900.053*
C60.7543 (3)0.0788 (2)0.05387 (11)0.0395 (5)
H60.70850.14780.01940.047*
C70.7288 (2)−0.1139 (2)−0.04408 (10)0.0346 (5)
C80.9800 (3)−0.0223 (3)0.30183 (12)0.0542 (6)
H8A0.9075 (15)−0.1129 (14)0.3028 (6)0.081*
H8B0.981 (2)0.0250 (9)0.3499 (7)0.081*
H8C1.1076 (19)−0.0452 (14)0.2900 (5)0.081*
O30.6035 (2)−0.17989 (15)−0.22870 (8)0.0506 (4)
O40.4130 (2)−0.35402 (14)−0.27537 (8)0.0448 (4)
H40.454 (4)−0.412 (3)−0.2291 (15)0.086 (8)*
O50.4872 (2)0.00180 (14)−0.34351 (8)0.0478 (4)
O60.3608 (2)−0.19541 (15)−0.39997 (8)0.0517 (4)
C90.4936 (3)−0.22516 (19)−0.27658 (11)0.0354 (5)
C100.4403 (3)−0.1325 (2)−0.34652 (11)0.0383 (5)
O2W0.7296 (9)−0.5215 (3)0.02842 (17)0.0531 (13)0.85 (2)
H21W0.646 (3)−0.530 (3)0.0600 (14)0.080*
H22W0.699 (4)−0.578 (3)−0.0102 (12)0.080*
O21W0.845 (10)−0.520 (2)0.008 (2)0.101 (17)0.15 (2)
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0703 (10)0.0445 (8)0.0369 (8)0.0073 (7)−0.0118 (7)−0.0061 (7)
N10.0728 (13)0.0325 (10)0.0385 (11)−0.0018 (9)−0.0083 (10)−0.0023 (9)
N20.0607 (12)0.0371 (11)0.0328 (11)−0.0035 (8)−0.0074 (9)0.0024 (8)
C10.0334 (10)0.0303 (10)0.0341 (11)−0.0011 (8)0.0007 (8)−0.0002 (8)
C20.0576 (13)0.0273 (10)0.0406 (12)0.0026 (9)−0.0034 (10)−0.0015 (9)
C30.0513 (13)0.0332 (10)0.0386 (12)0.0015 (9)−0.0080 (10)0.0052 (9)
C40.0373 (11)0.0383 (11)0.0353 (11)−0.0010 (8)−0.0021 (8)−0.0038 (9)
C50.0572 (13)0.0292 (10)0.0449 (13)0.0061 (9)−0.0045 (10)−0.0041 (9)
C60.0494 (12)0.0315 (10)0.0370 (11)0.0048 (9)−0.0043 (9)0.0042 (9)
C70.0354 (11)0.0333 (10)0.0348 (11)−0.0016 (8)−0.0007 (8)0.0009 (9)
C80.0646 (15)0.0563 (14)0.0402 (13)0.0030 (11)−0.0105 (11)0.0007 (11)
O30.0705 (10)0.0363 (8)0.0427 (9)−0.0050 (7)−0.0184 (8)−0.0008 (6)
O40.0650 (10)0.0293 (7)0.0386 (9)−0.0066 (6)−0.0096 (7)0.0046 (6)
O50.0765 (11)0.0278 (7)0.0379 (8)−0.0054 (7)−0.0081 (7)0.0019 (6)
O60.0857 (11)0.0329 (8)0.0343 (9)−0.0044 (7)−0.0164 (8)−0.0001 (6)
C90.0458 (12)0.0257 (9)0.0345 (11)0.0045 (8)−0.0006 (9)−0.0040 (8)
C100.0511 (12)0.0289 (10)0.0346 (11)0.0007 (9)−0.0014 (9)−0.0016 (8)
O2W0.074 (3)0.0401 (12)0.0453 (15)−0.0055 (13)0.0009 (14)−0.0065 (9)
O21W0.15 (4)0.067 (10)0.078 (16)0.022 (14)−0.04 (2)−0.021 (9)
Geometric parameters (Å, º) top
O1—C41.361 (2)C5—C61.370 (3)
O1—C81.427 (2)C5—H50.9300
N1—C71.317 (3)C6—H60.9300
N1—H1A0.92 (3)C8—H8A0.9696
N1—H1B0.92 (2)C8—H8B0.9697
N2—C71.302 (2)C8—H8C0.9696
N2—H2A0.86 (2)O3—C91.209 (2)
N2—H2B0.88 (2)O4—C91.300 (2)
C1—C21.383 (3)O4—H41.02 (3)
C1—C61.393 (3)O5—C101.260 (2)
C1—C71.470 (3)O6—C101.234 (2)
C2—C31.385 (3)C9—C101.549 (3)
C2—H20.9300O2W—O21W0.92 (8)
C3—C41.383 (3)O2W—H21W0.854 (17)
C3—H30.9300O2W—H22W0.883 (17)
C4—C51.382 (3)O21W—H22W1.20 (6)
C4—O1—C8118.00 (16)C5—C6—H6119.5
C7—N1—H1A121.5 (18)C1—C6—H6119.5
C7—N1—H1B120.6 (14)N2—C7—N1119.1 (2)
H1A—N1—H1B118 (2)N2—C7—C1120.56 (18)
C7—N2—H2A121.0 (15)N1—C7—C1120.28 (18)
C7—N2—H2B123.3 (14)O1—C8—H8A109.5
H2A—N2—H2B116 (2)O1—C8—H8B109.5
C2—C1—C6117.90 (17)H8A—C8—H8B109.5
C2—C1—C7121.50 (17)O1—C8—H8C109.5
C6—C1—C7120.59 (17)H8A—C8—H8C109.5
C1—C2—C3121.65 (18)H8B—C8—H8C109.5
C1—C2—H2119.2C9—O4—H4111.6 (15)
C3—C2—H2119.2O3—C9—O4124.20 (18)
C4—C3—C2119.22 (18)O3—C9—C10121.61 (17)
C4—C3—H3120.4O4—C9—C10114.18 (17)
C2—C3—H3120.4O6—C10—O5126.03 (18)
O1—C4—C5115.88 (17)O6—C10—C9118.28 (16)
O1—C4—C3124.32 (18)O5—C10—C9115.68 (17)
C5—C4—C3119.80 (18)O21W—O2W—H21W161 (2)
C6—C5—C4120.39 (18)O21W—O2W—H22W83 (2)
C6—C5—H5119.8H21W—O2W—H22W109 (3)
C4—C5—H5119.8O2W—O21W—H22W47 (3)
C5—C6—C1121.01 (18)
C6—C1—C2—C30.9 (3)C2—C1—C6—C5−1.6 (3)
C7—C1—C2—C3−178.30 (18)C7—C1—C6—C5177.63 (18)
C1—C2—C3—C40.7 (3)C2—C1—C7—N2−165.77 (19)
C8—O1—C4—C5−176.59 (18)C6—C1—C7—N215.0 (3)
C8—O1—C4—C33.7 (3)C2—C1—C7—N115.5 (3)
C2—C3—C4—O1177.98 (18)C6—C1—C7—N1−163.68 (19)
C2—C3—C4—C5−1.7 (3)O3—C9—C10—O6164.7 (2)
O1—C4—C5—C6−178.67 (17)O4—C9—C10—O6−14.1 (3)
C3—C4—C5—C61.1 (3)O3—C9—C10—O5−13.9 (3)
C4—C5—C6—C10.6 (3)O4—C9—C10—O5167.33 (17)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N1—H1A···O30.92 (3)2.43 (3)3.180 (3)138 (2)
N1—H1B···O2W0.92 (2)2.00 (2)2.891 (3)161 (2)
N1—H1A···O5i0.92 (3)2.37 (3)3.096 (2)135 (2)
N2—H2A···O30.86 (2)2.05 (2)2.869 (2)159 (2)
N2—H2A···O4ii0.86 (2)2.34 (2)2.827 (2)116.4 (18)
N2—H2B···O6ii0.88 (2)2.09 (3)2.932 (2)159.5 (19)
O4—H4···O5i1.02 (3)1.56 (3)2.5840 (19)178 (2)
O2W—H21W···O5iii0.85 (2)2.15 (2)2.976 (6)163 (3)
O2W—H22W···O6i0.88 (2)1.97 (2)2.853 (3)177 (3)
Symmetry codes: (i) −x+1, y−1/2, −z−1/2; (ii) −x+1, y+1/2, −z−1/2; (iii) x, −y−1/2, z+1/2.

Experimental details

Crystal data
Chemical formulaC8H11N2O+·C2HO4−·H2O
Mr258.23
Crystal system, space groupMonoclinic, P21/c
Temperature (K)298
a, b, c (Å)7.1444 (8), 9.0428 (7), 18.115 (2)
β (°) 93.156 (10)
V (Å3)1168.5 (2)
Z4
Radiation typeMo Kα
µ (mm−1)0.12
Crystal size (mm)0.18 × 0.12 × 0.09
Data collection
DiffractometerOxford Diffraction Xcalibur S CCD
diffractometer
Absorption correctionMulti-scan
(CrysAlis PRO; Agilent, 2011)
Tmin, Tmax0.978, 0.989
No. of measured, independent and
observed [I > 2σ(I)] reflections		15203, 2135, 1693
Rint0.046
(sin θ/λ)max (Å−1)0.602
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.047, 0.110, 1.09
No. of reflections2135
No. of parameters201
No. of restraints2
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å−3)0.16, −0.15

Computer programs: CrysAlis CCD (Oxford Diffraction, 2006), CrysAlis RED (Oxford Diffraction, 2006), SIR97 (Altomare et al., 1999), SHELXL97 (Sheldrick, 2008), ORTEP-3 (Farrugia, 2012), WinGX (Farrugia, 2012).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N1—H1A···O30.92 (3)2.43 (3)3.180 (3)138 (2)
N1—H1B···O2W0.92 (2)2.00 (2)2.891 (3)161 (2)
N1—H1A···O5i0.92 (3)2.37 (3)3.096 (2)135 (2)
N2—H2A···O30.86 (2)2.05 (2)2.869 (2)159 (2)
N2—H2A···O4ii0.86 (2)2.34 (2)2.827 (2)116.4 (18)
N2—H2B···O6ii0.88 (2)2.09 (3)2.932 (2)159.5 (19)
O4—H4···O5i1.02 (3)1.56 (3)2.5840 (19)178 (2)
O2W—H21W···O5iii0.854 (17)2.150 (19)2.976 (6)163 (3)
O2W—H22W···O6i0.883 (17)1.972 (18)2.853 (3)177 (3)
Symmetry codes: (i) −x+1, y−1/2, −z−1/2; (ii) −x+1, y+1/2, −z−1/2; (iii) x, −y−1/2, z+1/2.
 

References

First citationAgilent (2011). CrysAlis PRO. Agilent Technologies, Yarnton, England.  Google Scholar
 First citationAltomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Polidori, G. & Spagna, R. (1999). J. Appl. Cryst. 32, 115–119.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationBernstein, J., Davis, R. E., Shimoni, L. & Chang, N.-L. (1995). Angew. Chem. Int. Ed. Engl. 34, 1555–1573.  CrossRef CAS Web of Science Google Scholar
 First citationFarrugia, L. J. (2012). J. Appl. Cryst. 45, 849–854.  Web of Science CrossRef CAS IUCr Journals Google Scholar
 First citationIrrera, S., Ortaggi, G. & Portalone, G. (2012). Acta Cryst. C68, o447–o451.  Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
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 First citationOxford Diffraction (2006). CrysAlis CCD and CrysAlis RED. Oxford Diffraction Ltd, Yarnton, England.  Google Scholar
 First citationPortalone, G. (2010). Acta Cryst. C66, o295–o301.  Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
 First citationPortalone, G. (2011a). Chem. Centr. J. 5, 51.  Web of Science CSD CrossRef Google Scholar
 First citationPortalone, G. (2011b). Acta Cryst. E67, o3394–o3395.  Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
 First citationPortalone, G. (2012). Acta Cryst. E68, o268–o269.  Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
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This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

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ISSN: 2056-9890
Volume 68| Part 12| December 2012| Pages o3350-o3351
doi:10.1107/S1600536812046351
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