organic compounds
3-Hydroxy-1-(4-methoxybenzyl)piperidin-2-one
aMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, Johannesburg, South Africa
*Correspondence e-mail: joseph.michael@wits.ac.za
The title compound, C13H17NO3, adopts a conformation in which the aromatic ring and the mean plane of the piperidine ring are almost perpendicular to each other [dihedral angle = 79.25 (6)°]. The presence of the carbonyl group alters the conformation of the piperidine ring from a chair to a twisted half-chair conformation. In the crystal, pairs of strong O—H⋯O hydrogen bonds link the molecules into inversion dimers. Weak C—H⋯O interactions extend the hydrogen-bonding network into three dimensions.
Related literature
For the use of related et al. (2006). For information on the biological activity of febrifugine, a quinazoline alkaloid with potent antimalarial activity, see: Murata et al. (1998). For the use of chiral oxaziridines in asymmetric hydroxylation, see: Davis et al. (1990). For the conformation of six-membered rings, see: Boeyens (1978).
in the synthesis of febrifugine analogues, see: MichaelExperimental
Crystal data
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Data collection
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Refinement
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Data collection: APEX2 (Bruker, 2005); cell SAINT-NT (Bruker, 2005); data reduction: SAINT-NT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012) and SCHAKAL99 (Keller, 1999); software used to prepare material for publication: WinGX (Farrugia, 2012) and PLATON (Spek, 2009).
Supporting information
https://doi.org/10.1107/S1600536812049501/bh2468sup1.cif
contains datablocks global, I. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536812049501/bh2468Isup2.hkl
To a solution of lithium hexamethyldisilazide, prepared from n-butyllithium (1.6 M in hexane, 1.83 ml, 2.93 mmol) and hexamethyldisilazane (0.63 ml) in THF (10 ml) at -70 °C was added a solution of 1-(4-methoxybenzyl)piperidin-2-one (322 mg, 1.47 mmol) in THF (20 ml). The solution was stirred at this temperature for 1 h, after which a solution of (+)-camphorsulfonyloxaziridine (0.67 g, 2.9 mmol) in THF (20 ml) was added dropwise. Stirring was maintained for a further 16 h at temperatures kept between -70 and -60 °C. The reaction was quenched by addition of saturated aqueous ammonium chloride solution (10 ml) and allowed to warm to ambient temperature. The organic components were extracted with dichloromethane (4 × 15 ml), the combined organic layers were washed with brine (20 ml), dried over MgSO4, and concentrated in vacuo. Purification by
on silica gel with hexane-ethyl acetate mixtures (9:1 to 1:1 v/v) yielded the title compound, which was recrystallized from hexane-ethyl acetate to yield the product as irregularly shaped colourless crystals (261 mg, 75%), m.p. 347–349 K.All H atoms attached to C atoms were positioned geometrically, and allowed to ride on their parent atoms, with C—H bond lengths of 0.95 Å (Ar—H), 1.0 (CH), 0.99 Å (CH2) or 0.98 Å (CH3), and isotropic displacement parameters set to 1.2 (CH and CH2) or 1.5 times (CH3) the Ueq of the parent atom. The alcohol H atom (H2) was located from the difference map and refined freely with isotropic displacement parameter set to 1.5 times the Ueq of the parent atom O2.
The title piperidinone was prepared as an early intermediate for the total synthesis of febrifugine, a quinazoline alkaloid with potent antimalarial activity (Murata et al., 1998). Ongoing investigations in our laboratories have made use of similar
for the synthesis of febrifugine analogues (Michael et al., 2006). It should be noted that, although the 3-hydroxy substituent was introduced by attempted asymmetric hydroxylation of the enolate of 1-(4-methoxybenzyl)piperidin-2-one with (+)-camphorsulfonyloxaziridine (Davis et al., 1990), partial occurred; the crystals selected for analysis proved to be racemic.The title organic compound (Fig. 1) adopts a conformation in which the aromatic ring and the piperidine ring are almost perpendicular to each other. Ring puckering analysis, as implemented in PLATON (Spek, 2009), indicates that the piperidine ring adopts a twisted half-chair conformation owing to the presence of the carbonyl group (Boeyens, 1978). Several hydrogen bonds exist in the structure (Table 1), with the most significant being an O—H···O hydrogen bond. These result in the formation of hydrogen bonded pairs of molecules which are related to each other by a center of inversion (Fig. 1). These molecules interact further through C—H···O interactions (Fig. 2) resulting in an extensive hydrogen bonding network of molecules.
For the use of related
in the synthesis of febrifugine analogues, see: Michael et al. (2006). For information on the biological activity of febrifugine, a quinazoline alkaloid with potent antimalarial activity, see: Murata et al. (1998). For the use of chiral oxaziridines in asymmetric hydroxylation, see: Davis et al. (1990). For the conformation of six-membered rings, see: Boeyens (1978).Data collection: APEX2 (Bruker, 2005); cell
SAINT-NT (Bruker, 2005); data reduction: SAINT-NT (Bruker, 2005); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012) and SCHAKAL99 (Keller, 1999); software used to prepare material for publication: WinGX (Farrugia, 2012) and PLATON (Spek, 2009).C13H17NO3 | F(000) = 504 |
Mr = 235.28 | Dx = 1.297 Mg m−3 |
Monoclinic, P21/c | Melting point: 347 K |
Hall symbol: -P 2ybc | Mo Kα radiation, λ = 0.71073 Å |
a = 12.980 (3) Å | Cell parameters from 958 reflections |
b = 7.6143 (17) Å | θ = 3.5–28.3° |
c = 12.189 (3) Å | µ = 0.09 mm−1 |
β = 90.497 (5)° | T = 173 K |
V = 1204.6 (5) Å3 | Irregular, colourless |
Z = 4 | 0.32 × 0.26 × 0.18 mm |
Bruker APEXII CCD diffractometer | 2271 reflections with I > 2σ(I) |
Radiation source: fine-focus sealed tube | Rint = 0.027 |
Graphite monochromator | θmax = 28.0°, θmin = 3.1° |
φ and ω scans | h = −14→17 |
8378 measured reflections | k = −10→10 |
2895 independent reflections | l = −16→9 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.042 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.124 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.08 | w = 1/[σ2(Fo2) + (0.066P)2 + 0.1896P] where P = (Fo2 + 2Fc2)/3 |
2895 reflections | (Δ/σ)max < 0.001 |
158 parameters | Δρmax = 0.52 e Å−3 |
0 restraints | Δρmin = −0.22 e Å−3 |
0 constraints |
C13H17NO3 | V = 1204.6 (5) Å3 |
Mr = 235.28 | Z = 4 |
Monoclinic, P21/c | Mo Kα radiation |
a = 12.980 (3) Å | µ = 0.09 mm−1 |
b = 7.6143 (17) Å | T = 173 K |
c = 12.189 (3) Å | 0.32 × 0.26 × 0.18 mm |
β = 90.497 (5)° |
Bruker APEXII CCD diffractometer | 2271 reflections with I > 2σ(I) |
8378 measured reflections | Rint = 0.027 |
2895 independent reflections |
R[F2 > 2σ(F2)] = 0.042 | 0 restraints |
wR(F2) = 0.124 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.08 | Δρmax = 0.52 e Å−3 |
2895 reflections | Δρmin = −0.22 e Å−3 |
158 parameters |
x | y | z | Uiso*/Ueq | ||
C2 | 0.11028 (9) | 0.10275 (17) | 0.35921 (10) | 0.0283 (3) | |
C3 | 0.06871 (9) | −0.07971 (17) | 0.32619 (11) | 0.0304 (3) | |
H3 | −0.0060 | −0.0662 | 0.3072 | 0.037* | |
C4 | 0.12221 (11) | −0.15543 (17) | 0.22690 (12) | 0.0353 (3) | |
H4A | 0.0856 | −0.2621 | 0.2013 | 0.042* | |
H4B | 0.1939 | −0.1883 | 0.2463 | 0.042* | |
C5 | 0.12221 (11) | −0.01793 (18) | 0.13695 (11) | 0.0374 (3) | |
H5A | 0.1507 | −0.0688 | 0.0689 | 0.045* | |
H5B | 0.0508 | 0.0209 | 0.1214 | 0.045* | |
C6 | 0.18684 (10) | 0.13727 (17) | 0.17295 (10) | 0.0323 (3) | |
H6A | 0.2605 | 0.1038 | 0.1716 | 0.039* | |
H6B | 0.1766 | 0.2349 | 0.1204 | 0.039* | |
C7 | 0.20555 (10) | 0.36915 (17) | 0.31491 (12) | 0.0334 (3) | |
H7A | 0.1693 | 0.4153 | 0.3800 | 0.040* | |
H7B | 0.1951 | 0.4535 | 0.2540 | 0.040* | |
C8 | 0.31965 (10) | 0.35530 (15) | 0.34078 (11) | 0.0296 (3) | |
C9 | 0.35322 (10) | 0.27078 (17) | 0.43529 (11) | 0.0343 (3) | |
H9 | 0.3037 | 0.2227 | 0.4838 | 0.041* | |
C10 | 0.45748 (11) | 0.25429 (18) | 0.46121 (11) | 0.0349 (3) | |
H10 | 0.4786 | 0.1967 | 0.5268 | 0.042* | |
C11 | 0.53038 (10) | 0.32307 (16) | 0.39013 (11) | 0.0321 (3) | |
C12 | 0.49838 (10) | 0.4107 (2) | 0.29565 (12) | 0.0389 (3) | |
H12 | 0.5479 | 0.4600 | 0.2477 | 0.047* | |
C13 | 0.39415 (10) | 0.42600 (19) | 0.27143 (11) | 0.0365 (3) | |
H13 | 0.3730 | 0.4856 | 0.2066 | 0.044* | |
C14 | 0.66904 (13) | 0.2242 (2) | 0.50439 (15) | 0.0495 (4) | |
H14A | 0.6450 | 0.2894 | 0.5686 | 0.074* | |
H14B | 0.7445 | 0.2192 | 0.5055 | 0.074* | |
H14C | 0.6411 | 0.1047 | 0.5061 | 0.074* | |
N1 | 0.16062 (8) | 0.19805 (13) | 0.28388 (8) | 0.0270 (2) | |
O1 | 0.09468 (8) | 0.15790 (15) | 0.45317 (8) | 0.0444 (3) | |
O2 | 0.07623 (8) | −0.19755 (14) | 0.41449 (10) | 0.0457 (3) | |
H2 | 0.0256 (18) | −0.165 (3) | 0.4675 (17) | 0.069* | |
O3 | 0.63479 (7) | 0.31060 (14) | 0.40678 (9) | 0.0431 (3) |
U11 | U22 | U33 | U12 | U13 | U23 | |
C2 | 0.0217 (5) | 0.0342 (6) | 0.0289 (6) | −0.0031 (5) | −0.0005 (4) | 0.0000 (5) |
C3 | 0.0229 (6) | 0.0295 (6) | 0.0389 (7) | −0.0030 (5) | −0.0027 (5) | 0.0049 (5) |
C4 | 0.0332 (7) | 0.0276 (6) | 0.0451 (8) | 0.0003 (5) | −0.0046 (6) | −0.0036 (5) |
C5 | 0.0420 (8) | 0.0393 (7) | 0.0309 (7) | 0.0059 (6) | −0.0042 (5) | −0.0062 (5) |
C6 | 0.0340 (7) | 0.0356 (7) | 0.0272 (6) | 0.0037 (5) | 0.0051 (5) | 0.0026 (5) |
C7 | 0.0288 (6) | 0.0249 (6) | 0.0465 (8) | −0.0013 (5) | 0.0043 (5) | −0.0014 (5) |
C8 | 0.0284 (6) | 0.0234 (6) | 0.0371 (7) | −0.0034 (5) | 0.0042 (5) | −0.0038 (5) |
C9 | 0.0309 (7) | 0.0336 (7) | 0.0385 (7) | −0.0038 (5) | 0.0097 (5) | 0.0021 (5) |
C10 | 0.0352 (7) | 0.0348 (7) | 0.0349 (7) | −0.0028 (5) | 0.0019 (5) | 0.0031 (5) |
C11 | 0.0268 (6) | 0.0293 (6) | 0.0404 (7) | −0.0052 (5) | 0.0016 (5) | −0.0049 (5) |
C12 | 0.0318 (7) | 0.0448 (8) | 0.0402 (7) | −0.0106 (6) | 0.0075 (5) | 0.0056 (6) |
C13 | 0.0343 (7) | 0.0377 (7) | 0.0377 (7) | −0.0067 (6) | 0.0023 (5) | 0.0067 (6) |
C14 | 0.0375 (8) | 0.0456 (9) | 0.0652 (11) | −0.0059 (7) | −0.0124 (7) | 0.0064 (7) |
N1 | 0.0249 (5) | 0.0262 (5) | 0.0300 (5) | −0.0014 (4) | 0.0030 (4) | 0.0001 (4) |
O1 | 0.0430 (6) | 0.0598 (7) | 0.0307 (5) | −0.0174 (5) | 0.0094 (4) | −0.0094 (5) |
O2 | 0.0365 (6) | 0.0453 (6) | 0.0553 (7) | 0.0001 (4) | 0.0051 (5) | 0.0202 (5) |
O3 | 0.0268 (5) | 0.0473 (6) | 0.0553 (7) | −0.0067 (4) | −0.0021 (4) | 0.0046 (5) |
C2—O1 | 1.2381 (15) | C7—H7B | 0.9900 |
C2—N1 | 1.3443 (16) | C8—C9 | 1.3865 (19) |
C2—C3 | 1.5426 (18) | C8—C13 | 1.3977 (18) |
C3—O2 | 1.4039 (16) | C9—C10 | 1.393 (2) |
C3—C4 | 1.5145 (19) | C9—H9 | 0.9500 |
C3—H3 | 1.0000 | C10—C11 | 1.3909 (19) |
C4—C5 | 1.5160 (19) | C10—H10 | 0.9500 |
C4—H4A | 0.9900 | C11—O3 | 1.3719 (16) |
C4—H4B | 0.9900 | C11—C12 | 1.391 (2) |
C5—C6 | 1.5121 (19) | C12—C13 | 1.3871 (19) |
C5—H5A | 0.9900 | C12—H12 | 0.9500 |
C5—H5B | 0.9900 | C13—H13 | 0.9500 |
C6—N1 | 1.4717 (16) | C14—O3 | 1.4272 (19) |
C6—H6A | 0.9900 | C14—H14A | 0.9800 |
C6—H6B | 0.9900 | C14—H14B | 0.9800 |
C7—N1 | 1.4753 (16) | C14—H14C | 0.9800 |
C7—C8 | 1.5154 (18) | O2—H2 | 0.96 (2) |
C7—H7A | 0.9900 | ||
O1—C2—N1 | 122.21 (12) | C8—C7—H7B | 109.2 |
O1—C2—C3 | 119.16 (11) | H7A—C7—H7B | 107.9 |
N1—C2—C3 | 118.62 (11) | C9—C8—C13 | 117.85 (12) |
O2—C3—C4 | 109.87 (11) | C9—C8—C7 | 120.32 (11) |
O2—C3—C2 | 110.71 (11) | C13—C8—C7 | 121.84 (12) |
C4—C3—C2 | 112.93 (10) | C8—C9—C10 | 121.88 (12) |
O2—C3—H3 | 107.7 | C8—C9—H9 | 119.1 |
C4—C3—H3 | 107.7 | C10—C9—H9 | 119.1 |
C2—C3—H3 | 107.7 | C11—C10—C9 | 119.33 (13) |
C3—C4—C5 | 108.54 (11) | C11—C10—H10 | 120.3 |
C3—C4—H4A | 110.0 | C9—C10—H10 | 120.3 |
C5—C4—H4A | 110.0 | O3—C11—C10 | 123.94 (12) |
C3—C4—H4B | 110.0 | O3—C11—C12 | 116.31 (12) |
C5—C4—H4B | 110.0 | C10—C11—C12 | 119.75 (13) |
H4A—C4—H4B | 108.4 | C13—C12—C11 | 120.02 (12) |
C6—C5—C4 | 109.47 (10) | C13—C12—H12 | 120.0 |
C6—C5—H5A | 109.8 | C11—C12—H12 | 120.0 |
C4—C5—H5A | 109.8 | C12—C13—C8 | 121.16 (13) |
C6—C5—H5B | 109.8 | C12—C13—H13 | 119.4 |
C4—C5—H5B | 109.8 | C8—C13—H13 | 119.4 |
H5A—C5—H5B | 108.2 | O3—C14—H14A | 109.5 |
N1—C6—C5 | 112.35 (11) | O3—C14—H14B | 109.5 |
N1—C6—H6A | 109.1 | H14A—C14—H14B | 109.5 |
C5—C6—H6A | 109.1 | O3—C14—H14C | 109.5 |
N1—C6—H6B | 109.1 | H14A—C14—H14C | 109.5 |
C5—C6—H6B | 109.1 | H14B—C14—H14C | 109.5 |
H6A—C6—H6B | 107.9 | C2—N1—C6 | 125.13 (11) |
N1—C7—C8 | 112.04 (10) | C2—N1—C7 | 119.67 (11) |
N1—C7—H7A | 109.2 | C6—N1—C7 | 114.78 (10) |
C8—C7—H7A | 109.2 | C3—O2—H2 | 107.9 (12) |
N1—C7—H7B | 109.2 | C11—O3—C14 | 117.08 (12) |
O1—C2—C3—O2 | −36.84 (16) | O3—C11—C12—C13 | 178.67 (13) |
N1—C2—C3—O2 | 144.47 (12) | C10—C11—C12—C13 | −1.3 (2) |
O1—C2—C3—C4 | −160.52 (12) | C11—C12—C13—C8 | 0.3 (2) |
N1—C2—C3—C4 | 20.79 (15) | C9—C8—C13—C12 | 0.7 (2) |
O2—C3—C4—C5 | −174.31 (10) | C7—C8—C13—C12 | −179.32 (12) |
C2—C3—C4—C5 | −50.17 (14) | O1—C2—N1—C6 | 176.47 (12) |
C3—C4—C5—C6 | 64.96 (14) | C3—C2—N1—C6 | −4.89 (17) |
C4—C5—C6—N1 | −48.71 (15) | O1—C2—N1—C7 | 4.33 (18) |
N1—C7—C8—C9 | −70.61 (15) | C3—C2—N1—C7 | −177.02 (10) |
N1—C7—C8—C13 | 109.37 (14) | C5—C6—N1—C2 | 19.25 (17) |
C13—C8—C9—C10 | −0.5 (2) | C5—C6—N1—C7 | −168.28 (10) |
C7—C8—C9—C10 | 179.46 (12) | C8—C7—N1—C2 | 98.18 (13) |
C8—C9—C10—C11 | −0.5 (2) | C8—C7—N1—C6 | −74.74 (14) |
C9—C10—C11—O3 | −178.55 (12) | C10—C11—O3—C14 | −1.19 (19) |
C9—C10—C11—C12 | 1.5 (2) | C12—C11—O3—C14 | 178.80 (13) |
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2···O1i | 0.96 (2) | 1.84 (2) | 2.7708 (16) | 161.6 (19) |
C6—H6B···O1ii | 0.99 | 2.43 | 3.3142 (17) | 148 |
C14—H14B···O2iii | 0.98 | 2.52 | 3.449 (2) | 158 |
Symmetry codes: (i) −x, −y, −z+1; (ii) x, −y+1/2, z−1/2; (iii) −x+1, −y, −z+1. |
Experimental details
Crystal data | |
Chemical formula | C13H17NO3 |
Mr | 235.28 |
Crystal system, space group | Monoclinic, P21/c |
Temperature (K) | 173 |
a, b, c (Å) | 12.980 (3), 7.6143 (17), 12.189 (3) |
β (°) | 90.497 (5) |
V (Å3) | 1204.6 (5) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.09 |
Crystal size (mm) | 0.32 × 0.26 × 0.18 |
Data collection | |
Diffractometer | Bruker APEXII CCD |
Absorption correction | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 8378, 2895, 2271 |
Rint | 0.027 |
(sin θ/λ)max (Å−1) | 0.661 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.042, 0.124, 1.08 |
No. of reflections | 2895 |
No. of parameters | 158 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.52, −0.22 |
Computer programs: APEX2 (Bruker, 2005), SAINT-NT (Bruker, 2005), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), ORTEP-3 for Windows (Farrugia, 2012) and SCHAKAL99 (Keller, 1999), WinGX (Farrugia, 2012) and PLATON (Spek, 2009).
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2···O1i | 0.96 (2) | 1.84 (2) | 2.7708 (16) | 161.6 (19) |
C6—H6B···O1ii | 0.99 | 2.43 | 3.3142 (17) | 148 |
C14—H14B···O2iii | 0.98 | 2.52 | 3.449 (2) | 158 |
Symmetry codes: (i) −x, −y, −z+1; (ii) x, −y+1/2, z−1/2; (iii) −x+1, −y, −z+1. |
Acknowledgements
This work was supported by the University of the Witwatersrand and the National Research Foundation, Pretoria (grant No. 78837).
References
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The title piperidinone was prepared as an early intermediate for the total synthesis of febrifugine, a quinazoline alkaloid with potent antimalarial activity (Murata et al., 1998). Ongoing investigations in our laboratories have made use of similar lactams for the synthesis of febrifugine analogues (Michael et al., 2006). It should be noted that, although the 3-hydroxy substituent was introduced by attempted asymmetric hydroxylation of the enolate of 1-(4-methoxybenzyl)piperidin-2-one with (+)-camphorsulfonyloxaziridine (Davis et al., 1990), partial racemization occurred; the crystals selected for analysis proved to be racemic.
The title organic compound (Fig. 1) adopts a conformation in which the aromatic ring and the piperidine ring are almost perpendicular to each other. Ring puckering analysis, as implemented in PLATON (Spek, 2009), indicates that the piperidine ring adopts a twisted half-chair conformation owing to the presence of the carbonyl group (Boeyens, 1978). Several hydrogen bonds exist in the structure (Table 1), with the most significant being an O—H···O hydrogen bond. These result in the formation of hydrogen bonded pairs of molecules which are related to each other by a center of inversion (Fig. 1). These molecules interact further through C—H···O interactions (Fig. 2) resulting in an extensive hydrogen bonding network of molecules.