organic compounds
(3E)-11,16-Dioxatricyclo[15.4.0.05,10]henicosa-1(21),3,5,7,9,17,19-heptaen-2-one
aDepartment of Physics, SMK Fomra Institute of Technology, Thaiyur, Chennai 603 103, India, bDepartment of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India, and cDepartment of Physics, Presidency College (Autonomous), Chennai 600 005, India
*Correspondence e-mail: a_sp59@yahoo.in
The title compound, C19H18O3, crystallizes with three molecules (A, B and C) in the The carbonyl O atom shows positional disorder over two sites in molecules A and B; the site-occupancy ratios are 0.76 (3):0.24 (3) and 0.86 (3):0.14 (3), respectively. The ethylene fragments in each molecule have an E conformation, while the C—O—C—C torsion angles indicate near planarity. The dihedral angles formed by the aromatic rings are 20.0 (1), 23.7 (1) and 16.1 (1)° for molecules A, B and C, respectively. Intramolecular C—H⋯O hydrogen bonds occur in each molecule.
Related literature
For the biological activities of et al. (2004); Lee et al. (2006); Bhat et al. (2005); Satyanarayana et al. (2004). For a related crown ether structure, see: Anh et al. (2011).
see: XueExperimental
Crystal data
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Refinement
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Data collection: APEX2 (Bruker, 2008); cell SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 2012); software used to prepare material for publication: SHELXL97 and PLATON (Spek, 2009).
Supporting information
10.1107/S1600536813000299/bx2434sup1.cif
contains datablocks global, I. DOI:Structure factors: contains datablock I. DOI: 10.1107/S1600536813000299/bx2434Isup2.hkl
Supporting information file. DOI: 10.1107/S1600536813000299/bx2434Isup3.cml
To a solution of 2 g (5.08 mmol) of 2-(4-(4-((2-acetylphenoxy) methyl)-1H-1,2,3-triazol-1-yl) butoxy)benzaldehyde in 30 ml of methanol, 0.30 g (7.63 mmol) of NaOH in 30 ml of methanol was added drop wise and the mixture was stirred vigorously at room temperature for about 8 h. After the completion of the reaction, as evidenced by TLC analysis, the solvent was removed under vacuum. The crude product was then subjected to
using petroleum ether/ethylacetate (1:1) as The single crystal suitable for X-ray diffraction were obtained by slow evaporation of a solution of the title compound in methanol at room temperature.All H atoms were fixed geometrically and allowed to ride on their parent C atoms, with C—H distances fixed in the range 0.93–0.97 Å with Uiso(H) = 1.2Ueq(C) for other H atoms. The carbonyl group O atoms of two molecules shows positional disorder and were refined split into two positions with occupancies of 0.76 (3)/0.24 (3) and 0.86 (3)/0.14 (3).
Data collection: APEX2 (Bruker, 2008); cell
SAINT (Bruker, 2008); data reduction: SAINT (Bruker, 2008); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 2012); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).Fig. 1. The structure of the title compound, showing the atom-numbering scheme. The displacement ellipsoids are drawn at the 30% probability level. |
C19H18O3 | Z = 6 |
Mr = 294.34 | F(000) = 936 |
Triclinic, P1 | Dx = 1.269 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.71073 Å |
a = 9.0976 (6) Å | Cell parameters from 9919 reflections |
b = 16.9797 (11) Å | θ = 2.0–26.9° |
c = 17.2713 (9) Å | µ = 0.09 mm−1 |
α = 62.590 (2)° | T = 293 K |
β = 88.440 (2)° | Block, white crystalline |
γ = 78.092 (2)° | 0.40 × 0.30 × 0.25 mm |
V = 2310.4 (2) Å3 |
Bruker APEXII CCD area-detector diffractometer | 9919 independent reflections |
Radiation source: fine-focus sealed tube | 5862 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.032 |
ω and ϕ scans | θmax = 26.9°, θmin = 1.4° |
Absorption correction: multi-scan (SADABS; Bruker, 2008) | h = −11→11 |
Tmin = 0.967, Tmax = 0.979 | k = −21→21 |
44770 measured reflections | l = −21→21 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.045 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.143 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.04 | w = 1/[σ2(Fo2) + (0.063P)2 + 0.2901P] where P = (Fo2 + 2Fc2)/3 |
9919 reflections | (Δ/σ)max < 0.001 |
629 parameters | Δρmax = 0.19 e Å−3 |
15 restraints | Δρmin = −0.16 e Å−3 |
C19H18O3 | γ = 78.092 (2)° |
Mr = 294.34 | V = 2310.4 (2) Å3 |
Triclinic, P1 | Z = 6 |
a = 9.0976 (6) Å | Mo Kα radiation |
b = 16.9797 (11) Å | µ = 0.09 mm−1 |
c = 17.2713 (9) Å | T = 293 K |
α = 62.590 (2)° | 0.40 × 0.30 × 0.25 mm |
β = 88.440 (2)° |
Bruker APEXII CCD area-detector diffractometer | 9919 independent reflections |
Absorption correction: multi-scan (SADABS; Bruker, 2008) | 5862 reflections with I > 2σ(I) |
Tmin = 0.967, Tmax = 0.979 | Rint = 0.032 |
44770 measured reflections |
R[F2 > 2σ(F2)] = 0.045 | 15 restraints |
wR(F2) = 0.143 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.04 | Δρmax = 0.19 e Å−3 |
9919 reflections | Δρmin = −0.16 e Å−3 |
629 parameters |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2sigma(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
C1 | 0.2486 (2) | 0.55742 (11) | 0.08728 (12) | 0.0588 (5) | |
C2 | 0.3295 (3) | 0.56983 (13) | 0.01475 (14) | 0.0739 (6) | |
H2 | 0.4339 | 0.5592 | 0.0212 | 0.089* | |
C3 | 0.2613 (3) | 0.59712 (15) | −0.06609 (15) | 0.0862 (7) | |
H3 | 0.3189 | 0.6037 | −0.1132 | 0.103* | |
C4 | 0.1071 (3) | 0.61454 (15) | −0.07661 (15) | 0.0819 (6) | |
H4 | 0.0599 | 0.6341 | −0.1314 | 0.098* | |
C5 | 0.0222 (3) | 0.60341 (13) | −0.00704 (13) | 0.0705 (5) | |
H5 | −0.0822 | 0.6151 | −0.0149 | 0.085* | |
C6 | 0.0908 (2) | 0.57491 (12) | 0.07496 (12) | 0.0604 (5) | |
C7 | −0.1490 (2) | 0.58850 (16) | 0.13795 (14) | 0.0746 (6) | |
H7A | −0.1910 | 0.5576 | 0.1115 | 0.089* | |
H7B | −0.1840 | 0.6536 | 0.1023 | 0.089* | |
C8 | −0.1943 (2) | 0.55946 (15) | 0.22954 (14) | 0.0751 (6) | |
H8A | −0.3007 | 0.5853 | 0.2272 | 0.090* | |
H8B | −0.1389 | 0.5840 | 0.2573 | 0.090* | |
C9 | −0.1666 (2) | 0.45690 (16) | 0.28566 (15) | 0.0799 (6) | |
H9A | −0.2619 | 0.4386 | 0.2900 | 0.096* | |
H9B | −0.1012 | 0.4281 | 0.2563 | 0.096* | |
C10 | −0.0971 (2) | 0.42235 (16) | 0.37628 (14) | 0.0788 (6) | |
H10A | −0.1556 | 0.4536 | 0.4057 | 0.095* | |
H10B | −0.0919 | 0.3577 | 0.4105 | 0.095* | |
C11 | 0.1433 (2) | 0.42178 (13) | 0.43431 (13) | 0.0630 (5) | |
C12 | 0.1029 (2) | 0.38431 (14) | 0.51991 (13) | 0.0713 (5) | |
H12 | 0.0078 | 0.3714 | 0.5316 | 0.086* | |
C13 | 0.2019 (3) | 0.36627 (15) | 0.58727 (14) | 0.0776 (6) | |
H13 | 0.1743 | 0.3402 | 0.6445 | 0.093* | |
C14 | 0.3413 (3) | 0.38636 (16) | 0.57095 (15) | 0.0823 (6) | |
H14 | 0.4080 | 0.3749 | 0.6167 | 0.099* | |
C15 | 0.3817 (2) | 0.42369 (13) | 0.48619 (14) | 0.0720 (5) | |
H15 | 0.4765 | 0.4372 | 0.4757 | 0.086* | |
C16 | 0.2861 (2) | 0.44200 (12) | 0.41563 (12) | 0.0601 (5) | |
C17 | 0.3411 (2) | 0.47976 (13) | 0.32785 (14) | 0.0654 (5) | |
C18 | 0.2732 (2) | 0.49489 (13) | 0.25304 (13) | 0.0716 (6) | |
H18 | 0.1781 | 0.4823 | 0.2549 | 0.086* | |
C19 | 0.3368 (2) | 0.52898 (12) | 0.17062 (13) | 0.0663 (5) | |
C20 | 0.7253 (2) | −0.13378 (14) | 0.66919 (13) | 0.0646 (5) | |
C21 | 0.6521 (2) | −0.17445 (13) | 0.75325 (13) | 0.0626 (5) | |
C22 | 0.6970 (3) | −0.26840 (16) | 0.80557 (16) | 0.0811 (6) | |
H22 | 0.7659 | −0.3022 | 0.7855 | 0.097* | |
C23 | 0.6422 (3) | −0.31261 (17) | 0.88618 (18) | 0.0928 (7) | |
H23 | 0.6719 | −0.3754 | 0.9190 | 0.111* | |
C24 | 0.5441 (3) | −0.26358 (19) | 0.91737 (18) | 0.0963 (7) | |
H24 | 0.5100 | −0.2930 | 0.9726 | 0.116* | |
C25 | 0.4957 (3) | −0.17205 (16) | 0.86847 (15) | 0.0809 (6) | |
H25 | 0.4280 | −0.1395 | 0.8903 | 0.097* | |
C26 | 0.5470 (2) | −0.12669 (14) | 0.78589 (13) | 0.0644 (5) | |
C27 | 0.3856 (2) | 0.01519 (14) | 0.76303 (13) | 0.0705 (5) | |
H27A | 0.4206 | 0.0144 | 0.8160 | 0.085* | |
H27B | 0.2971 | −0.0108 | 0.7746 | 0.085* | |
C28 | 0.3489 (2) | 0.11039 (14) | 0.69007 (12) | 0.0674 (5) | |
H28A | 0.4423 | 0.1304 | 0.6721 | 0.081* | |
H28B | 0.2909 | 0.1495 | 0.7121 | 0.081* | |
C29 | 0.2608 (2) | 0.12287 (15) | 0.60977 (13) | 0.0698 (5) | |
H29A | 0.2617 | 0.0635 | 0.6148 | 0.084* | |
H29B | 0.1569 | 0.1520 | 0.6090 | 0.084* | |
C30 | 0.3217 (2) | 0.17845 (14) | 0.52471 (12) | 0.0666 (5) | |
H30A | 0.2539 | 0.1920 | 0.4757 | 0.080* | |
H30B | 0.3349 | 0.2352 | 0.5213 | 0.080* | |
C31 | 0.5525 (2) | 0.15677 (13) | 0.45736 (12) | 0.0564 (4) | |
C32 | 0.5141 (2) | 0.24309 (14) | 0.38767 (12) | 0.0672 (5) | |
H32 | 0.4224 | 0.2812 | 0.3844 | 0.081* | |
C33 | 0.6110 (3) | 0.27270 (17) | 0.32327 (15) | 0.0850 (6) | |
H33 | 0.5843 | 0.3307 | 0.2763 | 0.102* | |
C34 | 0.7463 (3) | 0.2176 (2) | 0.32775 (18) | 0.1040 (8) | |
H34 | 0.8125 | 0.2382 | 0.2845 | 0.125* | |
C35 | 0.7843 (3) | 0.13101 (18) | 0.39687 (16) | 0.0888 (7) | |
H35 | 0.8769 | 0.0940 | 0.3994 | 0.107* | |
C36 | 0.6886 (2) | 0.09715 (14) | 0.46310 (12) | 0.0611 (5) | |
C37 | 0.7366 (2) | 0.00422 (16) | 0.53391 (14) | 0.0654 (5) | |
C38 | 0.6604 (2) | −0.04329 (13) | 0.60039 (12) | 0.0615 (5) | |
H38 | 0.5610 | −0.0171 | 0.6027 | 0.074* | |
C39 | 0.93750 (19) | 0.19043 (12) | 0.74456 (11) | 0.0533 (4) | |
C40 | 0.8673 (2) | 0.28237 (13) | 0.69700 (13) | 0.0678 (5) | |
H40 | 0.8908 | 0.3236 | 0.7134 | 0.081* | |
C41 | 0.7645 (2) | 0.31371 (15) | 0.62675 (15) | 0.0797 (6) | |
H41 | 0.7184 | 0.3751 | 0.5969 | 0.096* | |
C42 | 0.7305 (2) | 0.25418 (16) | 0.60102 (15) | 0.0810 (6) | |
H42 | 0.6623 | 0.2754 | 0.5529 | 0.097* | |
C43 | 0.7958 (2) | 0.16383 (14) | 0.64527 (13) | 0.0697 (5) | |
H43 | 0.7717 | 0.1240 | 0.6270 | 0.084* | |
C44 | 0.89803 (19) | 0.13060 (12) | 0.71742 (11) | 0.0546 (4) | |
C45 | 0.9246 (2) | −0.02235 (13) | 0.73831 (13) | 0.0680 (5) | |
H45A | 0.9565 | −0.0116 | 0.6809 | 0.082* | |
H45B | 0.8162 | −0.0159 | 0.7369 | 0.082* | |
C46 | 1.0010 (2) | −0.11563 (13) | 0.80595 (13) | 0.0671 (5) | |
H46A | 1.1071 | −0.1172 | 0.8130 | 0.081* | |
H46B | 0.9933 | −0.1587 | 0.7848 | 0.081* | |
C47 | 0.9366 (2) | −0.14613 (13) | 0.89507 (13) | 0.0699 (5) | |
H47A | 0.8698 | −0.0941 | 0.8960 | 0.084* | |
H47B | 0.8769 | −0.1901 | 0.9030 | 0.084* | |
C48 | 1.0545 (2) | −0.18769 (13) | 0.97021 (13) | 0.0692 (5) | |
H48A | 1.0096 | −0.2139 | 1.0256 | 0.083* | |
H48B | 1.1307 | −0.2349 | 0.9666 | 0.083* | |
C49 | 1.2255 (2) | −0.12862 (13) | 1.02307 (11) | 0.0564 (4) | |
C50 | 1.2922 (2) | −0.21385 (14) | 1.08800 (13) | 0.0709 (5) | |
H50 | 1.2628 | −0.2649 | 1.0921 | 0.085* | |
C51 | 1.4023 (3) | −0.22336 (17) | 1.14669 (14) | 0.0836 (6) | |
H51 | 1.4475 | −0.2810 | 1.1902 | 0.100* | |
C52 | 1.4454 (3) | −0.14910 (19) | 1.14138 (15) | 0.0945 (7) | |
H52 | 1.5192 | −0.1558 | 1.1814 | 0.113* | |
C53 | 1.3792 (2) | −0.06407 (17) | 1.07647 (14) | 0.0808 (6) | |
H53 | 1.4099 | −0.0139 | 1.0735 | 0.097* | |
C54 | 1.26825 (19) | −0.05043 (13) | 1.01523 (11) | 0.0557 (4) | |
C55 | 1.2065 (2) | 0.04182 (13) | 0.94696 (12) | 0.0569 (4) | |
H55 | 1.2542 | 0.0861 | 0.9449 | 0.068* | |
C56 | 1.09217 (19) | 0.07140 (12) | 0.88751 (11) | 0.0534 (4) | |
H56 | 1.0363 | 0.0303 | 0.8898 | 0.064* | |
C57 | 1.0495 (2) | 0.16541 (12) | 0.81842 (12) | 0.0554 (4) | |
O1 | 0.4695 (2) | 0.54064 (15) | 0.16521 (13) | 0.1011 (9) | 0.797 (4) |
O1' | 0.4746 (8) | 0.4998 (7) | 0.3293 (9) | 0.100 (3) | 0.204 (4) |
O2 | 0.01235 (14) | 0.56378 (11) | 0.14559 (9) | 0.0789 (4) | |
O3 | 0.05022 (15) | 0.44048 (11) | 0.36520 (9) | 0.0831 (4) | |
O4 | 0.84438 (19) | −0.17918 (15) | 0.66161 (14) | 0.0896 (7) | 0.907 (4) |
O4' | 0.8606 (10) | −0.036 (2) | 0.519 (2) | 0.121 (9) | 0.095 (4) |
O5 | 0.50151 (15) | −0.03546 (9) | 0.73550 (8) | 0.0712 (4) | |
O6 | 0.46332 (14) | 0.12368 (9) | 0.52412 (8) | 0.0669 (4) | |
O7 | 1.10487 (18) | 0.22515 (9) | 0.81922 (10) | 0.0826 (4) | |
O8 | 0.96687 (14) | 0.04133 (8) | 0.76207 (8) | 0.0635 (3) | |
O9 | 1.11850 (16) | −0.11450 (8) | 0.96222 (8) | 0.0692 (4) | |
H17 | 0.4431 (7) | 0.4810 (13) | 0.327 (3) | 0.083* | 0.797 (4) |
H19 | 0.4298 (5) | 0.5422 (5) | 0.1523 (6) | 0.083* | 0.204 (4) |
H37 | 0.8275 (6) | −0.024 (3) | 0.522 (3) | 0.083* | 0.907 (4) |
H20 | 0.815 (2) | −0.166 (11) | 0.662 (11) | 0.083* | 0.095 (4) |
U11 | U22 | U33 | U12 | U13 | U23 | |
C1 | 0.0621 (12) | 0.0419 (10) | 0.0679 (12) | −0.0111 (8) | 0.0108 (9) | −0.0222 (9) |
C2 | 0.0787 (14) | 0.0573 (12) | 0.0780 (14) | −0.0147 (10) | 0.0209 (12) | −0.0257 (11) |
C3 | 0.108 (2) | 0.0759 (15) | 0.0725 (15) | −0.0216 (13) | 0.0268 (14) | −0.0332 (12) |
C4 | 0.114 (2) | 0.0695 (14) | 0.0671 (14) | −0.0258 (13) | 0.0062 (13) | −0.0332 (11) |
C5 | 0.0821 (14) | 0.0606 (12) | 0.0723 (13) | −0.0221 (10) | 0.0007 (11) | −0.0308 (11) |
C6 | 0.0680 (13) | 0.0512 (11) | 0.0638 (12) | −0.0162 (9) | 0.0098 (10) | −0.0271 (9) |
C7 | 0.0511 (11) | 0.0862 (15) | 0.0838 (14) | −0.0082 (10) | −0.0030 (10) | −0.0397 (12) |
C8 | 0.0482 (11) | 0.0897 (16) | 0.0924 (15) | −0.0108 (10) | 0.0067 (10) | −0.0482 (13) |
C9 | 0.0614 (13) | 0.0990 (18) | 0.0937 (16) | −0.0342 (12) | 0.0097 (11) | −0.0503 (14) |
C10 | 0.0625 (13) | 0.0915 (16) | 0.0852 (15) | −0.0322 (11) | 0.0170 (11) | −0.0378 (13) |
C11 | 0.0589 (12) | 0.0605 (12) | 0.0649 (12) | −0.0069 (9) | 0.0030 (9) | −0.0277 (10) |
C12 | 0.0671 (13) | 0.0722 (14) | 0.0730 (13) | −0.0095 (10) | 0.0118 (11) | −0.0352 (11) |
C13 | 0.0893 (17) | 0.0758 (15) | 0.0682 (13) | −0.0053 (12) | 0.0098 (12) | −0.0394 (11) |
C14 | 0.0887 (17) | 0.0839 (16) | 0.0762 (15) | −0.0056 (13) | −0.0079 (12) | −0.0434 (13) |
C15 | 0.0661 (13) | 0.0657 (13) | 0.0821 (15) | −0.0076 (10) | −0.0037 (11) | −0.0349 (11) |
C16 | 0.0546 (11) | 0.0507 (11) | 0.0690 (12) | −0.0038 (8) | −0.0004 (9) | −0.0257 (9) |
C17 | 0.0504 (11) | 0.0567 (12) | 0.0773 (14) | −0.0054 (9) | 0.0035 (11) | −0.0239 (10) |
C18 | 0.0493 (11) | 0.0829 (15) | 0.0690 (13) | −0.0173 (10) | 0.0036 (10) | −0.0227 (11) |
C19 | 0.0566 (12) | 0.0562 (12) | 0.0761 (13) | −0.0092 (9) | 0.0065 (10) | −0.0239 (10) |
C20 | 0.0573 (12) | 0.0747 (14) | 0.0786 (13) | −0.0071 (10) | −0.0052 (10) | −0.0521 (12) |
C21 | 0.0588 (11) | 0.0622 (12) | 0.0732 (12) | −0.0139 (9) | −0.0088 (9) | −0.0358 (10) |
C22 | 0.0760 (14) | 0.0733 (15) | 0.0978 (17) | −0.0102 (12) | −0.0179 (13) | −0.0440 (14) |
C23 | 0.0973 (19) | 0.0671 (15) | 0.0985 (19) | −0.0282 (14) | −0.0157 (15) | −0.0203 (14) |
C24 | 0.0984 (19) | 0.0875 (19) | 0.0934 (18) | −0.0382 (15) | 0.0097 (15) | −0.0268 (16) |
C25 | 0.0810 (15) | 0.0785 (16) | 0.0796 (15) | −0.0282 (12) | 0.0141 (12) | −0.0299 (13) |
C26 | 0.0610 (12) | 0.0670 (13) | 0.0699 (12) | −0.0207 (10) | 0.0024 (10) | −0.0328 (11) |
C27 | 0.0714 (13) | 0.0829 (15) | 0.0701 (12) | −0.0177 (11) | 0.0212 (10) | −0.0469 (12) |
C28 | 0.0715 (13) | 0.0739 (14) | 0.0701 (12) | −0.0128 (10) | 0.0194 (10) | −0.0466 (11) |
C29 | 0.0526 (11) | 0.0845 (14) | 0.0787 (13) | −0.0106 (10) | 0.0152 (10) | −0.0457 (12) |
C30 | 0.0570 (11) | 0.0759 (13) | 0.0704 (12) | −0.0012 (10) | 0.0084 (9) | −0.0426 (11) |
C31 | 0.0556 (11) | 0.0716 (13) | 0.0587 (11) | −0.0166 (9) | 0.0090 (8) | −0.0433 (10) |
C32 | 0.0712 (13) | 0.0709 (14) | 0.0661 (12) | −0.0156 (10) | 0.0090 (10) | −0.0375 (11) |
C33 | 0.0911 (17) | 0.0847 (16) | 0.0788 (15) | −0.0267 (14) | 0.0202 (13) | −0.0353 (13) |
C34 | 0.100 (2) | 0.105 (2) | 0.0972 (19) | −0.0329 (17) | 0.0438 (15) | −0.0366 (17) |
C35 | 0.0691 (14) | 0.1033 (19) | 0.0983 (17) | −0.0151 (13) | 0.0281 (13) | −0.0532 (16) |
C36 | 0.0560 (11) | 0.0763 (14) | 0.0653 (12) | −0.0148 (10) | 0.0089 (9) | −0.0450 (11) |
C37 | 0.0502 (11) | 0.0862 (15) | 0.0769 (13) | −0.0054 (11) | 0.0042 (11) | −0.0561 (12) |
C38 | 0.0540 (11) | 0.0717 (13) | 0.0677 (12) | −0.0020 (10) | 0.0015 (9) | −0.0445 (11) |
C39 | 0.0499 (10) | 0.0532 (11) | 0.0595 (10) | −0.0126 (8) | 0.0129 (8) | −0.0282 (9) |
C40 | 0.0667 (12) | 0.0571 (12) | 0.0801 (13) | −0.0163 (10) | 0.0156 (11) | −0.0317 (11) |
C41 | 0.0701 (14) | 0.0611 (13) | 0.0848 (15) | −0.0014 (11) | −0.0053 (12) | −0.0192 (12) |
C42 | 0.0704 (14) | 0.0776 (16) | 0.0792 (14) | −0.0040 (12) | −0.0134 (11) | −0.0272 (13) |
C43 | 0.0657 (12) | 0.0718 (14) | 0.0712 (13) | −0.0082 (10) | −0.0069 (10) | −0.0351 (11) |
C44 | 0.0491 (10) | 0.0569 (11) | 0.0592 (11) | −0.0095 (8) | 0.0053 (8) | −0.0290 (9) |
C45 | 0.0749 (13) | 0.0705 (13) | 0.0748 (13) | −0.0138 (10) | −0.0067 (10) | −0.0474 (11) |
C46 | 0.0723 (13) | 0.0632 (12) | 0.0829 (14) | −0.0085 (10) | −0.0070 (10) | −0.0501 (11) |
C47 | 0.0722 (13) | 0.0606 (12) | 0.0876 (14) | −0.0209 (10) | 0.0005 (11) | −0.0406 (11) |
C48 | 0.0858 (14) | 0.0536 (12) | 0.0744 (13) | −0.0209 (10) | −0.0016 (11) | −0.0321 (10) |
C49 | 0.0562 (11) | 0.0631 (12) | 0.0539 (10) | −0.0095 (9) | 0.0047 (8) | −0.0321 (9) |
C50 | 0.0760 (14) | 0.0668 (13) | 0.0653 (12) | −0.0101 (11) | 0.0009 (11) | −0.0289 (11) |
C51 | 0.0762 (15) | 0.0821 (16) | 0.0709 (14) | −0.0058 (12) | −0.0059 (11) | −0.0218 (12) |
C52 | 0.0787 (16) | 0.112 (2) | 0.0822 (16) | −0.0230 (15) | −0.0214 (13) | −0.0337 (16) |
C53 | 0.0742 (14) | 0.0912 (17) | 0.0804 (14) | −0.0287 (12) | −0.0087 (12) | −0.0376 (13) |
C54 | 0.0499 (10) | 0.0691 (12) | 0.0569 (10) | −0.0167 (9) | 0.0062 (8) | −0.0352 (10) |
C55 | 0.0574 (11) | 0.0632 (12) | 0.0663 (11) | −0.0226 (9) | 0.0090 (9) | −0.0399 (10) |
C56 | 0.0574 (11) | 0.0568 (11) | 0.0588 (10) | −0.0195 (8) | 0.0089 (9) | −0.0349 (9) |
C57 | 0.0579 (11) | 0.0554 (11) | 0.0649 (11) | −0.0177 (9) | 0.0146 (9) | −0.0362 (10) |
O1 | 0.0545 (12) | 0.139 (2) | 0.0884 (14) | −0.0309 (12) | 0.0096 (10) | −0.0315 (13) |
O1' | 0.079 (6) | 0.142 (8) | 0.090 (6) | −0.063 (5) | 0.018 (4) | −0.047 (6) |
O2 | 0.0511 (8) | 0.1105 (12) | 0.0688 (9) | −0.0109 (7) | 0.0041 (6) | −0.0391 (8) |
O3 | 0.0572 (8) | 0.1169 (12) | 0.0693 (9) | −0.0312 (8) | 0.0090 (7) | −0.0337 (8) |
O4 | 0.0751 (12) | 0.0944 (13) | 0.0961 (13) | 0.0129 (9) | 0.0005 (9) | −0.0541 (10) |
O4' | 0.052 (10) | 0.097 (15) | 0.162 (19) | 0.027 (10) | 0.005 (12) | −0.034 (13) |
O5 | 0.0779 (9) | 0.0655 (9) | 0.0703 (8) | −0.0123 (7) | 0.0215 (7) | −0.0338 (7) |
O6 | 0.0605 (8) | 0.0707 (9) | 0.0639 (8) | −0.0012 (6) | 0.0161 (6) | −0.0324 (7) |
O7 | 0.1009 (11) | 0.0641 (9) | 0.0927 (10) | −0.0327 (8) | −0.0031 (8) | −0.0382 (8) |
O8 | 0.0721 (8) | 0.0557 (8) | 0.0694 (8) | −0.0076 (6) | −0.0115 (6) | −0.0363 (7) |
O9 | 0.0904 (10) | 0.0537 (8) | 0.0676 (8) | −0.0195 (7) | −0.0140 (7) | −0.0289 (6) |
C1—C2 | 1.388 (3) | C29—H29A | 0.9700 |
C1—C6 | 1.406 (3) | C29—H29B | 0.9700 |
C1—C19 | 1.487 (3) | C30—O6 | 1.428 (2) |
C2—C3 | 1.372 (3) | C30—H30A | 0.9700 |
C2—H2 | 0.9300 | C30—H30B | 0.9700 |
C3—C4 | 1.371 (3) | C31—O6 | 1.358 (2) |
C3—H3 | 0.9300 | C31—C32 | 1.381 (3) |
C4—C5 | 1.370 (3) | C31—C36 | 1.402 (2) |
C4—H4 | 0.9300 | C32—C33 | 1.372 (3) |
C5—C6 | 1.386 (3) | C32—H32 | 0.9300 |
C5—H5 | 0.9300 | C33—C34 | 1.364 (3) |
C6—O2 | 1.353 (2) | C33—H33 | 0.9300 |
C7—O2 | 1.433 (2) | C34—C35 | 1.379 (3) |
C7—C8 | 1.499 (3) | C34—H34 | 0.9300 |
C7—H7A | 0.9700 | C35—C36 | 1.394 (3) |
C7—H7B | 0.9700 | C35—H35 | 0.9300 |
C8—C9 | 1.521 (3) | C36—C37 | 1.464 (3) |
C8—H8A | 0.9700 | C37—O4' | 1.276 (9) |
C8—H8B | 0.9700 | C37—C38 | 1.336 (3) |
C9—C10 | 1.500 (3) | C37—H37 | 0.935 (5) |
C9—H9A | 0.9700 | C38—H38 | 0.9300 |
C9—H9B | 0.9700 | C39—C40 | 1.399 (3) |
C10—O3 | 1.425 (2) | C39—C44 | 1.407 (2) |
C10—H10A | 0.9700 | C39—C57 | 1.496 (2) |
C10—H10B | 0.9700 | C40—C41 | 1.375 (3) |
C11—O3 | 1.355 (2) | C40—H40 | 0.9300 |
C11—C12 | 1.388 (3) | C41—C42 | 1.366 (3) |
C11—C16 | 1.404 (3) | C41—H41 | 0.9300 |
C12—C13 | 1.369 (3) | C42—C43 | 1.364 (3) |
C12—H12 | 0.9300 | C42—H42 | 0.9300 |
C13—C14 | 1.370 (3) | C43—C44 | 1.391 (3) |
C13—H13 | 0.9300 | C43—H43 | 0.9300 |
C14—C15 | 1.376 (3) | C44—O8 | 1.358 (2) |
C14—H14 | 0.9300 | C45—O8 | 1.440 (2) |
C15—C16 | 1.391 (3) | C45—C46 | 1.497 (3) |
C15—H15 | 0.9300 | C45—H45A | 0.9700 |
C16—C17 | 1.468 (3) | C45—H45B | 0.9700 |
C17—O1' | 1.331 (6) | C46—C47 | 1.524 (3) |
C17—C18 | 1.337 (3) | C46—H46A | 0.9700 |
C17—H17 | 0.933 (5) | C46—H46B | 0.9700 |
C18—C19 | 1.425 (3) | C47—C48 | 1.501 (3) |
C18—H18 | 0.9300 | C47—H47A | 0.9700 |
C19—O1 | 1.258 (2) | C47—H47B | 0.9700 |
C19—H19 | 0.930 (5) | C48—O9 | 1.428 (2) |
C20—O4 | 1.235 (2) | C48—H48A | 0.9700 |
C20—C38 | 1.451 (3) | C48—H48B | 0.9700 |
C20—C21 | 1.497 (3) | C49—O9 | 1.355 (2) |
C20—H20 | 0.930 (5) | C49—C50 | 1.379 (3) |
C21—C22 | 1.397 (3) | C49—C54 | 1.406 (2) |
C21—C26 | 1.400 (3) | C50—C51 | 1.377 (3) |
C22—C23 | 1.380 (3) | C50—H50 | 0.9300 |
C22—H22 | 0.9300 | C51—C52 | 1.359 (3) |
C23—C24 | 1.364 (4) | C51—H51 | 0.9300 |
C23—H23 | 0.9300 | C52—C53 | 1.375 (3) |
C24—C25 | 1.361 (3) | C52—H52 | 0.9300 |
C24—H24 | 0.9300 | C53—C54 | 1.388 (3) |
C25—C26 | 1.395 (3) | C53—H53 | 0.9300 |
C25—H25 | 0.9300 | C54—C55 | 1.460 (3) |
C26—O5 | 1.357 (2) | C55—C56 | 1.325 (2) |
C27—O5 | 1.433 (2) | C55—H55 | 0.9300 |
C27—C28 | 1.496 (3) | C56—C57 | 1.462 (2) |
C27—H27A | 0.9700 | C56—H56 | 0.9300 |
C27—H27B | 0.9700 | C57—O7 | 1.228 (2) |
C28—C29 | 1.527 (3) | O1—H19 | 0.420 (5) |
C28—H28A | 0.9700 | O1'—H17 | 0.484 (15) |
C28—H28B | 0.9700 | O4—H20 | 0.31 (3) |
C29—C30 | 1.500 (3) | O4'—H37 | 0.342 (12) |
C2—C1—C6 | 117.19 (18) | C28—C29—H29B | 108.8 |
C2—C1—C19 | 116.88 (18) | H29A—C29—H29B | 107.7 |
C6—C1—C19 | 125.91 (17) | O6—C30—C29 | 105.39 (16) |
C3—C2—C1 | 122.5 (2) | O6—C30—H30A | 110.7 |
C3—C2—H2 | 118.7 | C29—C30—H30A | 110.7 |
C1—C2—H2 | 118.7 | O6—C30—H30B | 110.7 |
C4—C3—C2 | 119.1 (2) | C29—C30—H30B | 110.7 |
C4—C3—H3 | 120.4 | H30A—C30—H30B | 108.8 |
C2—C3—H3 | 120.4 | O6—C31—C32 | 123.27 (17) |
C5—C4—C3 | 120.5 (2) | O6—C31—C36 | 115.58 (17) |
C5—C4—H4 | 119.7 | C32—C31—C36 | 121.15 (17) |
C3—C4—H4 | 119.7 | C33—C32—C31 | 120.1 (2) |
C4—C5—C6 | 120.5 (2) | C33—C32—H32 | 119.9 |
C4—C5—H5 | 119.8 | C31—C32—H32 | 119.9 |
C6—C5—H5 | 119.8 | C34—C33—C32 | 120.4 (2) |
O2—C6—C5 | 122.91 (18) | C34—C33—H33 | 119.8 |
O2—C6—C1 | 116.99 (17) | C32—C33—H33 | 119.8 |
C5—C6—C1 | 120.09 (18) | C33—C34—C35 | 119.5 (2) |
O2—C7—C8 | 105.59 (16) | C33—C34—H34 | 120.2 |
O2—C7—H7A | 110.6 | C35—C34—H34 | 120.2 |
C8—C7—H7A | 110.6 | C34—C35—C36 | 122.2 (2) |
O2—C7—H7B | 110.6 | C34—C35—H35 | 118.9 |
C8—C7—H7B | 110.6 | C36—C35—H35 | 118.9 |
H7A—C7—H7B | 108.8 | C35—C36—C31 | 116.46 (19) |
C7—C8—C9 | 113.87 (18) | C35—C36—C37 | 118.94 (18) |
C7—C8—H8A | 108.8 | C31—C36—C37 | 124.58 (17) |
C9—C8—H8A | 108.8 | O4'—C37—C38 | 119.5 (18) |
C7—C8—H8B | 108.8 | O4'—C37—C36 | 110.8 (18) |
C9—C8—H8B | 108.8 | C38—C37—C36 | 128.95 (17) |
H8A—C8—H8B | 107.7 | O4'—C37—H37 | 1 (5) |
C10—C9—C8 | 114.65 (18) | C38—C37—H37 | 121 (3) |
C10—C9—H9A | 108.6 | C36—C37—H37 | 109 (3) |
C8—C9—H9A | 108.6 | C37—C38—C20 | 123.12 (18) |
C10—C9—H9B | 108.6 | C37—C38—H38 | 118.4 |
C8—C9—H9B | 108.6 | C20—C38—H38 | 118.4 |
H9A—C9—H9B | 107.6 | C40—C39—C44 | 116.89 (17) |
O3—C10—C9 | 105.56 (16) | C40—C39—C57 | 116.85 (16) |
O3—C10—H10A | 110.6 | C44—C39—C57 | 126.25 (16) |
C9—C10—H10A | 110.6 | C41—C40—C39 | 122.10 (19) |
O3—C10—H10B | 110.6 | C41—C40—H40 | 119.0 |
C9—C10—H10B | 110.6 | C39—C40—H40 | 119.0 |
H10A—C10—H10B | 108.8 | C42—C41—C40 | 119.6 (2) |
O3—C11—C12 | 123.02 (18) | C42—C41—H41 | 120.2 |
O3—C11—C16 | 116.58 (17) | C40—C41—H41 | 120.2 |
C12—C11—C16 | 120.39 (19) | C43—C42—C41 | 120.6 (2) |
C13—C12—C11 | 120.5 (2) | C43—C42—H42 | 119.7 |
C13—C12—H12 | 119.7 | C41—C42—H42 | 119.7 |
C11—C12—H12 | 119.7 | C42—C43—C44 | 120.7 (2) |
C12—C13—C14 | 120.4 (2) | C42—C43—H43 | 119.7 |
C12—C13—H13 | 119.8 | C44—C43—H43 | 119.7 |
C14—C13—H13 | 119.8 | O8—C44—C43 | 122.17 (16) |
C13—C14—C15 | 119.3 (2) | O8—C44—C39 | 117.63 (15) |
C13—C14—H14 | 120.4 | C43—C44—C39 | 120.16 (17) |
C15—C14—H14 | 120.4 | O8—C45—C46 | 107.12 (14) |
C14—C15—C16 | 122.5 (2) | O8—C45—H45A | 110.3 |
C14—C15—H15 | 118.7 | C46—C45—H45A | 110.3 |
C16—C15—H15 | 118.7 | O8—C45—H45B | 110.3 |
C15—C16—C11 | 116.87 (18) | C46—C45—H45B | 110.3 |
C15—C16—C17 | 118.42 (18) | H45A—C45—H45B | 108.5 |
C11—C16—C17 | 124.71 (18) | C45—C46—C47 | 114.28 (16) |
O1'—C17—C18 | 121.0 (6) | C45—C46—H46A | 108.7 |
O1'—C17—C16 | 111.1 (6) | C47—C46—H46A | 108.7 |
C18—C17—C16 | 127.94 (18) | C45—C46—H46B | 108.7 |
O1'—C17—H17 | 14.2 (12) | C47—C46—H46B | 108.7 |
C18—C17—H17 | 116 (3) | H46A—C46—H46B | 107.6 |
C16—C17—H17 | 114 (3) | C48—C47—C46 | 113.72 (17) |
C17—C18—C19 | 124.49 (19) | C48—C47—H47A | 108.8 |
C17—C18—H18 | 117.8 | C46—C47—H47A | 108.8 |
C19—C18—H18 | 117.8 | C48—C47—H47B | 108.8 |
O1—C19—C18 | 120.5 (2) | C46—C47—H47B | 108.8 |
O1—C19—C1 | 116.98 (19) | H47A—C47—H47B | 107.7 |
C18—C19—C1 | 122.37 (18) | O9—C48—C47 | 105.23 (15) |
O1—C19—H19 | 13.9 (6) | O9—C48—H48A | 110.7 |
C18—C19—H19 | 134.5 (6) | C47—C48—H48A | 110.7 |
C1—C19—H19 | 103.1 (6) | O9—C48—H48B | 110.7 |
O4—C20—C38 | 121.5 (2) | C47—C48—H48B | 110.7 |
O4—C20—C21 | 117.6 (2) | H48A—C48—H48B | 108.8 |
C38—C20—C21 | 120.96 (17) | O9—C49—C50 | 123.04 (17) |
O4—C20—H20 | 2 (10) | O9—C49—C54 | 115.83 (16) |
C38—C20—H20 | 120 (10) | C50—C49—C54 | 121.12 (17) |
C21—C20—H20 | 119 (10) | C51—C50—C49 | 120.0 (2) |
C22—C21—C26 | 116.9 (2) | C51—C50—H50 | 120.0 |
C22—C21—C20 | 116.97 (19) | C49—C50—H50 | 120.0 |
C26—C21—C20 | 126.07 (18) | C52—C51—C50 | 120.4 (2) |
C23—C22—C21 | 122.0 (2) | C52—C51—H51 | 119.8 |
C23—C22—H22 | 119.0 | C50—C51—H51 | 119.8 |
C21—C22—H22 | 119.0 | C51—C52—C53 | 119.7 (2) |
C24—C23—C22 | 119.6 (2) | C51—C52—H52 | 120.2 |
C24—C23—H23 | 120.2 | C53—C52—H52 | 120.2 |
C22—C23—H23 | 120.2 | C52—C53—C54 | 122.4 (2) |
C25—C24—C23 | 120.6 (2) | C52—C53—H53 | 118.8 |
C25—C24—H24 | 119.7 | C54—C53—H53 | 118.8 |
C23—C24—H24 | 119.7 | C53—C54—C49 | 116.41 (18) |
C24—C25—C26 | 120.5 (2) | C53—C54—C55 | 119.04 (17) |
C24—C25—H25 | 119.8 | C49—C54—C55 | 124.54 (16) |
C26—C25—H25 | 119.8 | C56—C55—C54 | 129.21 (17) |
O5—C26—C25 | 122.03 (19) | C56—C55—H55 | 115.4 |
O5—C26—C21 | 117.57 (17) | C54—C55—H55 | 115.4 |
C25—C26—C21 | 120.4 (2) | C55—C56—C57 | 123.24 (16) |
O5—C27—C28 | 106.78 (15) | C55—C56—H56 | 118.4 |
O5—C27—H27A | 110.4 | C57—C56—H56 | 118.4 |
C28—C27—H27A | 110.4 | O7—C57—C56 | 121.13 (17) |
O5—C27—H27B | 110.4 | O7—C57—C39 | 118.62 (16) |
C28—C27—H27B | 110.4 | C56—C57—C39 | 120.25 (15) |
H27A—C27—H27B | 108.6 | C19—O1—H19 | 32.3 (13) |
C27—C28—C29 | 114.89 (17) | C17—O1'—H17 | 28.3 (18) |
C27—C28—H28A | 108.5 | C6—O2—C7 | 121.20 (15) |
C29—C28—H28A | 108.5 | C11—O3—C10 | 121.56 (16) |
C27—C28—H28B | 108.5 | C20—O4—H20 | 5 (10) |
C29—C28—H28B | 108.5 | C37—O4'—H37 | 4 (10) |
H28A—C28—H28B | 107.5 | C26—O5—C27 | 119.54 (15) |
C30—C29—C28 | 113.87 (17) | C31—O6—C30 | 120.30 (15) |
C30—C29—H29A | 108.8 | C44—O8—C45 | 119.07 (14) |
C28—C29—H29A | 108.8 | C49—O9—C48 | 120.23 (14) |
C30—C29—H29B | 108.8 | ||
C6—C1—C2—C3 | −0.6 (3) | C32—C31—C36—C35 | 2.4 (3) |
C19—C1—C2—C3 | −179.13 (19) | O6—C31—C36—C37 | 1.0 (3) |
C1—C2—C3—C4 | 1.2 (3) | C32—C31—C36—C37 | −178.98 (17) |
C2—C3—C4—C5 | −1.1 (3) | C35—C36—C37—O4' | −5.5 (3) |
C3—C4—C5—C6 | 0.4 (3) | C31—C36—C37—O4' | 175.9 (3) |
C4—C5—C6—O2 | 179.27 (18) | C35—C36—C37—C38 | −175.71 (19) |
C4—C5—C6—C1 | 0.2 (3) | C31—C36—C37—C38 | 5.7 (3) |
C2—C1—C6—O2 | −179.23 (16) | O4'—C37—C38—C20 | 14.1 (4) |
C19—C1—C6—O2 | −0.9 (3) | C36—C37—C38—C20 | −176.43 (17) |
C2—C1—C6—C5 | −0.1 (3) | O4—C20—C38—C37 | −14.3 (3) |
C19—C1—C6—C5 | 178.27 (17) | C21—C20—C38—C37 | 163.96 (17) |
O2—C7—C8—C9 | −69.8 (2) | C44—C39—C40—C41 | −0.1 (3) |
C7—C8—C9—C10 | 135.73 (19) | C57—C39—C40—C41 | 178.80 (17) |
C8—C9—C10—O3 | −66.2 (2) | C39—C40—C41—C42 | −1.0 (3) |
O3—C11—C12—C13 | 179.56 (19) | C40—C41—C42—C43 | 1.1 (3) |
C16—C11—C12—C13 | −0.2 (3) | C41—C42—C43—C44 | 0.0 (3) |
C11—C12—C13—C14 | 1.1 (3) | C42—C43—C44—O8 | −178.90 (18) |
C12—C13—C14—C15 | −0.9 (3) | C42—C43—C44—C39 | −1.2 (3) |
C13—C14—C15—C16 | −0.1 (3) | C40—C39—C44—O8 | 179.03 (15) |
C14—C15—C16—C11 | 0.9 (3) | C57—C39—C44—O8 | 0.2 (3) |
C14—C15—C16—C17 | −178.48 (18) | C40—C39—C44—C43 | 1.2 (2) |
O3—C11—C16—C15 | 179.47 (17) | C57—C39—C44—C43 | −177.58 (17) |
C12—C11—C16—C15 | −0.7 (3) | O8—C45—C46—C47 | 71.1 (2) |
O3—C11—C16—C17 | −1.2 (3) | C45—C46—C47—C48 | −133.37 (17) |
C12—C11—C16—C17 | 178.60 (18) | C46—C47—C48—O9 | 68.7 (2) |
C15—C16—C17—O1' | −6.6 (5) | O9—C49—C50—C51 | 178.75 (18) |
C11—C16—C17—O1' | 174.1 (5) | C54—C49—C50—C51 | 0.2 (3) |
C15—C16—C17—C18 | 173.84 (18) | C49—C50—C51—C52 | 0.3 (3) |
C11—C16—C17—C18 | −5.5 (3) | C50—C51—C52—C53 | −0.5 (4) |
O1'—C17—C18—C19 | 2.8 (5) | C51—C52—C53—C54 | 0.2 (4) |
C16—C17—C18—C19 | −177.69 (17) | C52—C53—C54—C49 | 0.3 (3) |
C17—C18—C19—O1 | 5.5 (2) | C52—C53—C54—C55 | −178.4 (2) |
C17—C18—C19—C1 | −170.82 (18) | O9—C49—C54—C53 | −179.17 (16) |
C2—C1—C19—O1 | 17.7 (3) | C50—C49—C54—C53 | −0.5 (3) |
C6—C1—C19—O1 | −160.68 (19) | O9—C49—C54—C55 | −0.5 (2) |
C2—C1—C19—C18 | −165.91 (16) | C50—C49—C54—C55 | 178.11 (17) |
C6—C1—C19—C18 | 15.7 (3) | C53—C54—C55—C56 | −173.20 (19) |
O4—C20—C21—C22 | −18.2 (3) | C49—C54—C55—C56 | 8.2 (3) |
C38—C20—C21—C22 | 163.50 (17) | C54—C55—C56—C57 | −175.25 (16) |
O4—C20—C21—C26 | 159.25 (18) | C55—C56—C57—O7 | −10.3 (3) |
C38—C20—C21—C26 | −19.0 (3) | C55—C56—C57—C39 | 169.22 (16) |
C26—C21—C22—C23 | −0.7 (3) | C40—C39—C57—O7 | −19.8 (2) |
C20—C21—C22—C23 | 177.04 (18) | C44—C39—C57—O7 | 159.01 (17) |
C21—C22—C23—C24 | −1.7 (3) | C40—C39—C57—C56 | 160.68 (15) |
C22—C23—C24—C25 | 2.4 (4) | C44—C39—C57—C56 | −20.5 (3) |
C23—C24—C25—C26 | −0.7 (4) | C5—C6—O2—C7 | −5.4 (3) |
C24—C25—C26—O5 | −179.8 (2) | C1—C6—O2—C7 | 173.73 (17) |
C24—C25—C26—C21 | −1.7 (3) | C8—C7—O2—C6 | 175.49 (17) |
C22—C21—C26—O5 | −179.53 (17) | C12—C11—O3—C10 | −0.2 (3) |
C20—C21—C26—O5 | 3.0 (3) | C16—C11—O3—C10 | 179.64 (18) |
C22—C21—C26—C25 | 2.3 (3) | C9—C10—O3—C11 | 176.79 (18) |
C20—C21—C26—C25 | −175.11 (18) | C25—C26—O5—C27 | −6.7 (3) |
O5—C27—C28—C29 | 72.9 (2) | C21—C26—O5—C27 | 175.18 (16) |
C27—C28—C29—C30 | −133.58 (18) | C28—C27—O5—C26 | −173.76 (16) |
C28—C29—C30—O6 | 68.8 (2) | C32—C31—O6—C30 | 0.3 (3) |
O6—C31—C32—C33 | 178.75 (17) | C36—C31—O6—C30 | −179.69 (16) |
C36—C31—C32—C33 | −1.3 (3) | C29—C30—O6—C31 | −176.31 (15) |
C31—C32—C33—C34 | −0.5 (3) | C43—C44—O8—C45 | −4.8 (3) |
C32—C33—C34—C35 | 1.1 (4) | C39—C44—O8—C45 | 177.49 (16) |
C33—C34—C35—C36 | 0.1 (4) | C46—C45—O8—C44 | −171.89 (15) |
C34—C35—C36—C31 | −1.8 (3) | C50—C49—O9—C48 | 8.7 (3) |
C34—C35—C36—C37 | 179.5 (2) | C54—C49—O9—C48 | −172.64 (16) |
O6—C31—C36—C35 | −177.69 (17) | C47—C48—O9—C49 | 177.11 (15) |
D—H···A | D—H | H···A | D···A | D—H···A |
C2—H2···O1 | 0.93 | 2.37 | 2.712 (3) | 101 |
C18—H18···O2 | 0.93 | 2.15 | 2.746 (2) | 121 |
C18—H18···O3 | 0.93 | 2.12 | 2.763 (2) | 126 |
C38—H38···O5 | 0.93 | 2.24 | 2.753 (2) | 114 |
C38—H38···O6 | 0.93 | 2.13 | 2.753 (3) | 123 |
C55—H55···O7 | 0.93 | 2.50 | 2.829 (2) | 101 |
C56—H56···O8 | 0.93 | 2.23 | 2.766 (2) | 116 |
C56—H56···O9 | 0.93 | 2.15 | 2.764 (2) | 122 |
Experimental details
Crystal data | |
Chemical formula | C19H18O3 |
Mr | 294.34 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 293 |
a, b, c (Å) | 9.0976 (6), 16.9797 (11), 17.2713 (9) |
α, β, γ (°) | 62.590 (2), 88.440 (2), 78.092 (2) |
V (Å3) | 2310.4 (2) |
Z | 6 |
Radiation type | Mo Kα |
µ (mm−1) | 0.09 |
Crystal size (mm) | 0.40 × 0.30 × 0.25 |
Data collection | |
Diffractometer | Bruker APEXII CCD area-detector diffractometer |
Absorption correction | Multi-scan (SADABS; Bruker, 2008) |
Tmin, Tmax | 0.967, 0.979 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 44770, 9919, 5862 |
Rint | 0.032 |
(sin θ/λ)max (Å−1) | 0.637 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.045, 0.143, 1.04 |
No. of reflections | 9919 |
No. of parameters | 629 |
No. of restraints | 15 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.19, −0.16 |
Computer programs: APEX2 (Bruker, 2008), SAINT (Bruker, 2008), SHELXS97 (Sheldrick, 2008), ORTEP-3 (Farrugia, 2012), SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).
D—H···A | D—H | H···A | D···A | D—H···A |
C2—H2···O1 | 0.93 | 2.37 | 2.712 (3) | 101 |
C18—H18···O2 | 0.93 | 2.15 | 2.746 (2) | 121 |
C18—H18···O3 | 0.93 | 2.12 | 2.763 (2) | 126 |
C38—H38···O5 | 0.93 | 2.24 | 2.753 (2) | 114 |
C38—H38···O6 | 0.93 | 2.13 | 2.753 (3) | 123 |
C55—H55···O7 | 0.93 | 2.50 | 2.829 (2) | 101 |
C56—H56···O8 | 0.93 | 2.23 | 2.766 (2) | 116 |
C56—H56···O9 | 0.93 | 2.15 | 2.764 (2) | 122 |
Acknowledgements
The authors thank Dr Babu Varghese and SAIF, IIT, Chennai, India, for the data collection.
References
Anh, L. T., Hieu, T. H., Soldatenkov, A. T., Soldatova, S. A. & Khrustalev, V. N. (2011). Acta Cryst. E67, o1128–o1129. Web of Science CSD CrossRef IUCr Journals Google Scholar
Bhat, B. A., Dhar, K. L., Puri, S. C., Saxena, A. K., Shanmugavel, M. & Qazi, G. N. (2005). Bioorg. Med. Chem. Lett. 15, 3177–3180. Web of Science CrossRef PubMed CAS Google Scholar
Bruker. (2008). APEX2 and SAINT and SADABS. Bruker AXS Inc., Madison, Wisconsin, USA. Google Scholar
Farrugia, L. J. (2012). J. Appl. Cryst. 45, 849–854. Web of Science CrossRef CAS IUCr Journals Google Scholar
Lee, Y. S., Lim, S. S., Shin, K. H., Kim, Y. S., Ohuchi, K. & Jung, S. H. (2006). Biol. Pharm. Bull. 29, 1028–1031. Web of Science CrossRef PubMed CAS Google Scholar
Satyanarayana, M., Tiwari, P., Tripathi, B. K., Srivastava, A. K. & Pratap, R. (2004). Bioorg. Med. Chem. Lett. 12, 883–889. CrossRef CAS Google Scholar
Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. Web of Science CrossRef CAS IUCr Journals Google Scholar
Spek, A. L. (2009). Acta Cryst. D65, 148–155. Web of Science CrossRef CAS IUCr Journals Google Scholar
Xue, C. X., Cui, S. Y., Liu, M. C., Hu, Z. D. & Fan, B. T. (2004). Eur. J. Med. Chem. 39, 745–753. Web of Science CrossRef PubMed CAS Google Scholar
This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
Chalcone derivatives possess a wide range of biological properties such as antimalarial (Xue et al., 2004), antiangiogenic and antitumour (Lee et al., 2006), anticancer (Bhat et al., 2005) and antihyperglycemic (Satyanarayana et al., 2004) activities. Chalcones have been widely studied and developed as one of the pharmaceutically important molecules. Herein we report the crystal structure of the title compound.
The macomolecular structure of the title compound, C57H52O9, includes 14-crown-2-ether skeletal moiety (Fig. 1). The bond lengths and bond angles are comparable with the related crown ether structure (Anh et al., 2011). The compound crystallizes with three independent molecules (A, B and C) per asymmetric unit. Out of three molecules, two molecules are disordered with two alternate positions for the O atoms [atom O1/O1' in molecule A, and O4/O4' in molecule B] with site occupancies are 0.76/0.24 and 0.86/0.14. The ethylene fragments in all the three molecules have E configuration, while the C—O—C—C torsion angles indicate planarity of the segments. The dihedral angles between the aromatic rings are 20.0 (1), 23.7 (1) and 16.1 (1)° for molecules A, B and C, respectively.
Each molecule of the asymmetric unit exhibits intramolecular C—H···O hydrogen bonds [Table 1].