Crystal structure of 2-ethyl-3-(4-fluoro­phenyl­sulfon­yl)-5,7-dimethyl-1-benzo­furan

Choi, H.D.; Lee, U.

doi:10.1107/S1600536814019436

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ISSN: 2056-9890

Volume 70| Part 10| October 2014| Pages 249-251

doi:10.1107/S1600536814019436

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Crystal structure of 2-ethyl-3-(4-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran

Hong Dae Choi ^a and Uk Lee ^b ^*

^aDepartment of Chemistry, Dongeui University, San 24 Kaya-dong, Busanjin-gu, Busan 614-714, Republic of Korea, and ^bDepartment of Chemistry, Pukyong National University, 599-1 Daeyeon 3-dong, Nam-gu, Busan 608-737, Republic of Korea
^*Correspondence e-mail: uklee@pknu.ac.kr

Edited by P. Bombicz, Hungarian Academy of Sciences, Hungary (Received 15 August 2014; accepted 15 September 2014; online 24 September 2014)

In the title compound, C₁₈H₁₇FO₃S, the dihedral angle between the plane of the benzofuran ring [r.m.s. deviation = 0.006 (1) Å] and that of the 4-fluorophenyl ring [r.m.s. deviation = 0.004 (1) Å] is 82.45 (4)°. In the crystal, molecules are linked via three different pairs of C—H⋯O hydrogen bonds, forming chains along [001] and enclosing two R²₂(10) and one R²₂(12) ring motifs. The chains are further linked by π–π interactions [inter-centroid distance = 3.566 (1) Å] between the furan rings of inversion-related molecules, forming a two-dimensional network lying parallel to (100).

Keywords: crystal structure; benzofuran; 4-fluorophenyl; sulfonyl; hydrogen bonds; π–π interactions..

CCDC reference: 1021511

1. Chemical Context

Substituted benzofurans show important pharmacological properties such as antibacterial and antifungal, antitumour and antiviral, and antimicrobial activities (Aslam et al. 2009 ; Galal et al., 2009 ; Khan et al., 2005 ), and are potential inhibitors of β-amyloid aggregation (Howlett et al., 1999 ; Ono et al., 2002 ). These benzofuran compounds occur in a great number of natural products (Akgul & Anil, 2003 ; Soekamto et al., 2003 ). As a part of our ongoing project concerning 2-alkyl-3-(phenylsulfonyl)-5,7-dimethyl-1-benzofuran derivatives, we report herein on the synthesis and crystal structure of the title compound.

2. Structural commentary

In the title molecule, Fig. 1, the benzofuran unit (O1/C1–C8) is essentially planar, with a mean deviation of 0.006 (1) Å from the mean plane defined by the nine constituent atoms. The 4-fluorophenyl ring (C13–C18) is inclined to the benzofuran ring by 82.45 (4)°.

Figure 1
The molecular structure of the title molecule, with atom labelling. Displacement ellipsoids are drawn at the 50% probability level.

3. Supramolecular features

In the crystal, molecules are linked via three different pairs of C—H⋯O hydrogen bonds, forming chains along [001] and enclosing two $[R_{2}^{2}]$ (10) and one $[R_{2}^{2}]$ (12) ring motifs (Fig. 2 and Table 1). The chains are further linked by π–π interactions between the furan rings of inversion-related molecules, forming a two-dimensional network lying parallel to (100) [illustrated in Fig. 2; Cg1⋯Cg1ⁱ = 3.566 (1), interplanar distance = 3.553 (1); slippage = 0.305 Å; Cg1 is the centroid of the C1/C2/C7/O1/C8 furan ring; symmetry code: (i) −x + 1, −y + 1, −z + 1].

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C3—H3⋯O3ⁱ	0.95	2.55	3.4804 (18)	167
C14—H14⋯O2ⁱⁱ	0.95	2.49	3.1211 (17)	124
C18—H18⋯O3ⁱ	0.95	2.36	3.2742 (17)	160
Symmetry codes: (i) -x+1, -y+2, -z+1; (ii) -x+1, -y+2, -z.

Figure 2
A view of the C—H⋯O and π–π interactions (dotted lines) in the crystal structure of the title compound [see Table 1

for details; H atoms not involved in hydrogen bonding have been omitted for clarity; symmetry codes: (i) −x + 1, −y + 2, −z + 1; (ii) −x + 1, −y + 2, −z; (iii) −x + 1, −y + 1, −z + 1].

4. Database survey

A search of the Cambridge Structural Database (Version 5.35, last update May 2014; Allen, 2002 ) for 3-(phenylsulfonyl)benzofuran gave 65 hits. Six of these involve 5,7-dimethyl-3-(phenylsulfonyl)benzofuran derivatives. They include the 2-methyl derivative of the title compound, 2-methyl-3-(4-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran (Choi et al., 2010 ). In these six compounds, the dihedral angle between the phenylsulfonyl ring and the benzofuran ring varies from ca. 72.68° in the 2-methyl derivative mentioned above, to 87.61° in 2-methyl-3-(2-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran (Choi et al., 2014 ). The same angle in the title compound is 82.45 (4)°.

5. Synthesis and crystallization

The starting material 2-ethyl-3-(4-fluorophenylsulfanyl)-5,7-dimethyl-1-benzofuran was prepared by a literature method (Choi et al. 1999 ). 3-Chloroperoxybenzoic acid (77%, 448 mg, 2.0 mmol) was added in small portions to a stirred solution of 2-ethyl-3-(4-fluorophenylsulfanyl)-5,7-dimethyl-1-benzofuran (270 mg, 0.9 mmol) in dichloromethane (35 ml) at 273 K. After being stirred at room temperature for 8h, the mixture was washed with saturated sodium bicarbonate solution (2 × 15 ml) and the organic layer was separated, dried over magnesium sulfate, filtered and concentrated at reduced pressure. The residue was purified by column chromatography (hexane–ethyl acetate, 4:1 v/v) to afford the title compound as a colourless solid [yield 61% (236 mg); m.p. 416–417 K; R_f = 0.63 (hexane–ethyl acetate, 4:1 v/v)]. Single crystals suitable for X-ray diffraction were prepared by slow evaporation of a solution of the title compound (21 mg) in acetone (15 ml) at room temperature. ¹H NMR (δ p.p.m., CDCl₃, 400 Hz): 7.99–8.04 (m, 2H), 7.47 (s, 1H), 7.14–7.19 (m, 2H), 6.93 (s, 1H), 3.22 (q, J = 7.52 Hz, 2H), 2.43 (s, 3H), 2.41 (s, 3H), 1.36 (t, J = 7.54 Hz, 3H).

6. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 2. All H atoms were positioned geometrically and refined as riding atoms: C—H = 0.95 Å for aryl, 0.99 Å for methylene and 0.98 Å for methyl H atoms, respectively, with U_iso(H) = 1.5U_eq(C) for methyl H atoms and = 1.2U_eq(C) for other H atoms.

Table 2
Experimental details

Crystal data
Chemical formula	C₁₈H₁₇FO₃S
M_r	332.38
Crystal system, space group	Triclinic, P $[\overline{1}]$
Temperature (K)	173
a, b, c (Å)	8.8756 (2), 9.3917 (2), 11.0284 (2)
α, β, γ (°)	65.735 (1), 80.735 (1), 71.145 (1)
V (Å³)	792.68 (3)
Z	2
Radiation type	Mo Kα
μ (mm⁻¹)	0.23
Crystal size (mm)	0.39 × 0.33 × 0.30

Data collection
Diffractometer	Bruker SMART APEXII CCD
Absorption correction	Multi-scan (SADABS; Bruker, 2009 )
T_min, T_max	0.918, 0.936
No. of measured, independent and observed [I > 2σ(I)] reflections	14813, 3934, 3489
R_int	0.025
(sin θ/λ)_max (Å⁻¹)	0.668

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.037, 0.108, 1.07
No. of reflections	3934
No. of parameters	211
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.29, −0.44
Computer programs: APEX2 and SAINT (Bruker, 2009), SHELXS97 and SHELXL2014 (Sheldrick, 2008 ), ORTEP-3 for Windows (Farrugia, 2012 ), DIAMOND (Brandenburg, 1998 ) and PLATON (Spek, 2009 ).

Supporting information

CCDC reference: 1021511

Crystal structure: contains datablock I. DOI: 10.1107/S1600536814019436/zp2015sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S1600536814019436/zp2015Isup2.hkl

Supporting information file. DOI: 10.1107/S1600536814019436/zp2015Isup3.cml

checkCIF report

Chemical Context top

Substituted benzofurans show important pharmacological properties such as antibacterial and antifungal, antitumour and antiviral, and antimicrobial activities (Aslam et al. 2009; Galal et al., 2009; Khan et al., 2005), and are potential inhibitors of β-amyloid aggregation (Howlett et al., 1999; Ono et al., 2002). These benzofuran compounds occur in a great number of natural products (Akgul & Anil, 2003; Soekamto et al., 2003). As a part of our ongoing project concerning 2-alkyl-3-(phenylsulfonyl)-5,7-dimethyl-1-benzofuran derivatives, we report herein on the synthesis and crystal structure of the title compound.

Structural commentary top

Supramolecular features top

In the crystal, molecules are linked via three different pairs of C—H···O hydrogen bonds, forming chains along [001] and enclosing two R²₂(10) and one R²₂(12) ring motifs (Fig. 2 and Table 1). The chains are further linked by π–π interactions between the furan rings of inversion-related molecules, forming a two-dimensional network lying parallel to (100) [illustrated in Fig. 2; Cg1···Cg1ⁱ = 3.566 (1), interplanar distance = 3.553 (1); slippage = 0.305 Å; Cg1 is the centroid of the C1/C2/C7/O1/C8 furan ring; symmetry code: (i) -x+1, -y+1, -z+1].

Database survey top

A search of the Cambridge Structural Database (Version 5.35, last update May 2014; Allen, 2002) for 3-(phenylsulfonyl)benzofuran gave 65 hits. Six of these involve 5,7-dimethyl-3-(phenylsulfonyl)benzofuran derivatives. They include the 2-methyl derivative of the title compound, 2-methyl-3-(4-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran (Choi et al., 2010). In these six compounds, the dihedral angle between the phenylsulfonyl ring and the benzofuran ring varies from ca. 72.68° in the 2-methyl derivative mentioned above, to 87.61° in 2-methyl-3-(2-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran (Choi et al., 2014). The same angle in the title compound is 82.45 (4)°.

Synthesis and crystallization top

The starting material 2-ethyl-3-(4-fluorophenylsulfanyl)-5,7-dimethyl-1-benzofuran was prepared by a literature method (Choi et al. 1999). 3-Chloroperoxybenzoic acid (77%, 448 mg, 2.0 mmol) was added in small portions to a stirred solution of 2-ethyl-3-(4-fluorophenylsulfanyl)-5,7-dimethyl-1-benzofuran (270 mg, 0.9 mmol) in dichloromethane (35 ml) at 273 K. After being stirred at room temperature for 8h, the mixture was washed with saturated sodium bicarbonate solution (2 × 15 ml) and the organic layer was separated, dried over magnesium sulfate, filtered and concentrated at reduced pressure. The residue was purified by column chromatography (hexane–ethyl acetate, 4:1 v/v) to afford the title compound as a colourless solid [yield 61% (236 mg); m.p. 416–417 K; R_f = 0.63 (hexane–ethyl acetate, 4:1 v/v)]. Single crystals suitable for X-ray diffraction were prepared by slow evaporation of a solution of the title compound (21 mg) in acetone (15 ml) at room temperature. ¹H NMR (δ p.p.m., CDCl₃, 400 Hz): 7.99–8.04 (m, 2H), 7.47 (s, 1H), 7.14–7.19 (m, 2H), 6.93 (s, 1H), 3.22 (q, J = 7.52 Hz, 2H), 2.43 (s, 3H), 2.41 (s, 3H), 1.36 (t, J = 7.54 Hz, 3H).

Refinement top

Crystal data, data collection and structure refinement details are summarized in Table ₁. All H atoms were positioned geometrically and refined as riding atoms: C—H = 0.95 Å for aryl, 0.99 Å for methylene and 0.98 Å for methyl H atoms, respectively, with U_iso(H) = 1.5U_eq(C) for methyl H atoms and = 1.2U_eq(C) for other H atoms.

Related literature top

For the pharmacological properties of benzofuran compounds, see: Aslam et al. (2009); Galal et al. (2009); Howlett et al. (1999); Khan et al. (2005); Ono et al. (2002). For natural products with a benzofuran ring, see: Akgul & Anil (2003); Soekamto et al. (2003). For the synthesis of the starting material 2-ethyl-3-(4-fluorophenylsulfanyl)-5,7-dimethyl-1-benzofuran. see: Choi et al. (1999). For a related structure, see: Choi et al. (2010).

Computing details top

Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT (Bruker, 2009); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL2014 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012) and DIAMOND (Brandenburg, 1998); software used to prepare material for publication: SHELXL2014 (Sheldrick, 2008) and PLATON (Spek, 2009).

Figures top

	Fig. 1. The molecular structure of the title molecule, with atom labelling. Displacement ellipsoids are drawn at the 50% probability level.
	Fig. 2. A view of the C—H···O and π–π interactions (dotted lines) in the crystal structure of the title compound [see Table 1 for details; H atoms not involved in hydrogen bonding have been omitted for clarity; symmetry codes: (i) -x + 1, -y + 2, -z + 1; (ii) -x + 1, -y + 2, -z; (iii) -x + 1, -y + 1, -z + 1].

2-Ethyl-3-(4-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran top

Crystal data top

C₁₈H₁₇FO₃S	Z = 2
M_r = 332.38	F(000) = 348
Triclinic, P1	D_x = 1.393 Mg m⁻³
Hall symbol: -P 1	Melting point = 417–416 K
a = 8.8756 (2) Å	Mo Kα radiation, λ = 0.71073 Å
b = 9.3917 (2) Å	Cell parameters from 6147 reflections
c = 11.0284 (2) Å	θ = 2.4–28.2°
α = 65.735 (1)°	µ = 0.23 mm⁻¹
β = 80.735 (1)°	T = 173 K
γ = 71.145 (1)°	Block, colourless
V = 792.68 (3) Å³	0.39 × 0.33 × 0.30 mm

Data collection top

Bruker SMART APEXII CCD diffractometer	3934 independent reflections
Radiation source: rotating anode	3489 reflections with I > 2σ(I)
Graphite multilayer monochromator	R_int = 0.025
Detector resolution: 10.0 pixels mm^-1	θ_max = 28.4°, θ_min = 2.0°
ϕ and ω scans	h = −11→11
Absorption correction: multi-scan (SADABS; Bruker, 2009)	k = −12→12
T_min = 0.918, T_max = 0.936	l = −14→14
14813 measured reflections

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.037	Hydrogen site location: difference Fourier map
wR(F²) = 0.108	H-atom parameters constrained
S = 1.07	w = 1/[σ²(F_o²) + (0.0587P)² + 0.2229P] where P = (F_o² + 2F_c²)/3
3934 reflections	(Δ/σ)_max < 0.001
211 parameters	Δρ_max = 0.29 e Å⁻³
0 restraints	Δρ_min = −0.44 e Å⁻³

Crystal data top

C₁₈H₁₇FO₃S	γ = 71.145 (1)°
M_r = 332.38	V = 792.68 (3) Å³
Triclinic, P1	Z = 2
a = 8.8756 (2) Å	Mo Kα radiation
b = 9.3917 (2) Å	µ = 0.23 mm⁻¹
c = 11.0284 (2) Å	T = 173 K
α = 65.735 (1)°	0.39 × 0.33 × 0.30 mm
β = 80.735 (1)°

Data collection top

Bruker SMART APEXII CCD diffractometer	3934 independent reflections
Absorption correction: multi-scan (SADABS; Bruker, 2009)	3489 reflections with I > 2σ(I)
T_min = 0.918, T_max = 0.936	R_int = 0.025
14813 measured reflections

Refinement top

R[F² > 2σ(F²)] = 0.037	0 restraints
wR(F²) = 0.108	H-atom parameters constrained
S = 1.07	Δρ_max = 0.29 e Å⁻³
3934 reflections	Δρ_min = −0.44 e Å⁻³
211 parameters

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
S1	0.47686 (4)	0.90767 (4)	0.29373 (3)	0.02612 (11)
F1	0.95796 (13)	1.25062 (13)	0.04333 (11)	0.0519 (3)
O1	0.69433 (12)	0.44317 (12)	0.38093 (10)	0.0329 (2)
O2	0.37720 (12)	0.93598 (13)	0.19098 (10)	0.0339 (2)
O3	0.40523 (12)	0.95254 (13)	0.40432 (10)	0.0331 (2)
C1	0.58429 (16)	0.70342 (16)	0.35637 (13)	0.0268 (3)
C2	0.68621 (15)	0.62616 (16)	0.46953 (13)	0.0274 (3)
C3	0.72804 (16)	0.67484 (18)	0.55984 (13)	0.0300 (3)
H3	0.6840	0.7834	0.5555	0.036*
C4	0.83619 (17)	0.5600 (2)	0.65658 (14)	0.0343 (3)
C5	0.89864 (17)	0.40020 (19)	0.66131 (15)	0.0374 (3)
H5	0.9724	0.3241	0.7282	0.045*
C6	0.85859 (17)	0.34717 (18)	0.57367 (15)	0.0352 (3)
C7	0.75119 (16)	0.46619 (17)	0.47913 (14)	0.0304 (3)
C8	0.59290 (16)	0.58923 (17)	0.30738 (14)	0.0296 (3)
C9	0.8875 (2)	0.6073 (2)	0.75486 (16)	0.0472 (4)
H9A	0.8299	0.7212	0.7398	0.071*
H9B	1.0023	0.5946	0.7432	0.071*
H9C	0.8636	0.5370	0.8456	0.071*
C10	0.9270 (2)	0.17627 (19)	0.57832 (19)	0.0461 (4)
H10A	0.8523	0.1503	0.5397	0.069*
H10B	0.9449	0.0998	0.6710	0.069*
H10C	1.0284	0.1673	0.5273	0.069*
C11	0.52011 (18)	0.58876 (19)	0.19537 (15)	0.0364 (3)
H11A	0.4181	0.6764	0.1747	0.044*
H11B	0.4962	0.4836	0.2233	0.044*
C12	0.6270 (2)	0.6136 (2)	0.06985 (16)	0.0425 (4)
H12A	0.6419	0.7225	0.0361	0.064*
H12B	0.5772	0.6031	0.0020	0.064*
H12C	0.7307	0.5311	0.0907	0.064*
C13	0.62269 (16)	1.01143 (16)	0.21923 (13)	0.0261 (3)
C14	0.68862 (17)	1.01386 (17)	0.09555 (13)	0.0306 (3)
H14	0.6562	0.9596	0.0527	0.037*
C15	0.80202 (18)	1.09615 (19)	0.03520 (14)	0.0348 (3)
H15	0.8485	1.0998	−0.0495	0.042*
C16	0.84549 (18)	1.17233 (17)	0.10114 (15)	0.0349 (3)
C17	0.7805 (2)	1.17300 (18)	0.22324 (15)	0.0363 (3)
H17	0.8130	1.2283	0.2650	0.044*
C18	0.66666 (17)	1.09115 (17)	0.28363 (14)	0.0307 (3)
H18	0.6194	1.0895	0.3677	0.037*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
S1	0.02580 (17)	0.02980 (17)	0.02171 (17)	−0.00369 (12)	−0.00149 (12)	−0.01186 (13)
F1	0.0532 (6)	0.0496 (6)	0.0541 (6)	−0.0289 (5)	0.0052 (5)	−0.0128 (5)
O1	0.0315 (5)	0.0285 (5)	0.0380 (5)	−0.0076 (4)	0.0000 (4)	−0.0131 (4)
O2	0.0317 (5)	0.0415 (6)	0.0287 (5)	−0.0063 (4)	−0.0073 (4)	−0.0145 (4)
O3	0.0316 (5)	0.0399 (5)	0.0275 (5)	−0.0046 (4)	0.0029 (4)	−0.0185 (4)
C1	0.0262 (6)	0.0289 (6)	0.0241 (6)	−0.0070 (5)	0.0012 (5)	−0.0104 (5)
C2	0.0243 (6)	0.0301 (6)	0.0240 (6)	−0.0092 (5)	0.0027 (5)	−0.0069 (5)
C3	0.0280 (6)	0.0354 (7)	0.0243 (6)	−0.0101 (5)	0.0016 (5)	−0.0092 (5)
C4	0.0288 (7)	0.0445 (8)	0.0244 (6)	−0.0135 (6)	0.0014 (5)	−0.0067 (6)
C5	0.0288 (7)	0.0398 (8)	0.0293 (7)	−0.0094 (6)	−0.0023 (6)	0.0008 (6)
C6	0.0271 (7)	0.0299 (7)	0.0371 (8)	−0.0084 (5)	0.0021 (6)	−0.0028 (6)
C7	0.0265 (6)	0.0307 (7)	0.0303 (7)	−0.0100 (5)	0.0028 (5)	−0.0081 (5)
C8	0.0266 (6)	0.0313 (6)	0.0306 (7)	−0.0084 (5)	0.0018 (5)	−0.0124 (6)
C9	0.0453 (9)	0.0623 (11)	0.0312 (8)	−0.0132 (8)	−0.0081 (7)	−0.0144 (8)
C10	0.0366 (8)	0.0301 (7)	0.0568 (10)	−0.0065 (6)	−0.0028 (7)	−0.0042 (7)
C11	0.0357 (7)	0.0402 (8)	0.0403 (8)	−0.0100 (6)	−0.0021 (6)	−0.0226 (7)
C12	0.0564 (10)	0.0399 (8)	0.0350 (8)	−0.0134 (7)	−0.0004 (7)	−0.0187 (7)
C13	0.0284 (6)	0.0242 (6)	0.0225 (6)	−0.0029 (5)	−0.0030 (5)	−0.0086 (5)
C14	0.0339 (7)	0.0341 (7)	0.0252 (6)	−0.0077 (6)	−0.0014 (5)	−0.0139 (6)
C15	0.0358 (7)	0.0366 (7)	0.0279 (7)	−0.0081 (6)	0.0023 (6)	−0.0114 (6)
C16	0.0339 (7)	0.0274 (6)	0.0368 (8)	−0.0090 (6)	−0.0029 (6)	−0.0052 (6)
C17	0.0464 (8)	0.0290 (7)	0.0359 (8)	−0.0101 (6)	−0.0072 (6)	−0.0133 (6)
C18	0.0382 (7)	0.0281 (6)	0.0253 (6)	−0.0055 (5)	−0.0033 (5)	−0.0121 (5)

Geometric parameters (Å, º) top

S1—O2	1.4353 (10)	C9—H9B	0.9800
S1—O3	1.4383 (10)	C9—H9C	0.9800
S1—C1	1.7341 (14)	C10—H10A	0.9800
S1—C13	1.7648 (14)	C10—H10B	0.9800
F1—C16	1.3520 (17)	C10—H10C	0.9800
O1—C8	1.3684 (17)	C11—C12	1.525 (2)
O1—C7	1.3833 (18)	C11—H11A	0.9900
C1—C8	1.3630 (19)	C11—H11B	0.9900
C1—C2	1.4482 (18)	C12—H12A	0.9800
C2—C7	1.3892 (19)	C12—H12B	0.9800
C2—C3	1.3935 (19)	C12—H12C	0.9800
C3—C4	1.392 (2)	C13—C14	1.3891 (18)
C3—H3	0.9500	C13—C18	1.3901 (19)
C4—C5	1.403 (2)	C14—C15	1.385 (2)
C4—C9	1.505 (2)	C14—H14	0.9500
C5—C6	1.389 (2)	C15—C16	1.373 (2)
C5—H5	0.9500	C15—H15	0.9500
C6—C7	1.385 (2)	C16—C17	1.379 (2)
C6—C10	1.503 (2)	C17—C18	1.385 (2)
C8—C11	1.485 (2)	C17—H17	0.9500
C9—H9A	0.9800	C18—H18	0.9500

O2—S1—O3	119.08 (6)	C6—C10—H10A	109.5
O2—S1—C1	108.98 (6)	C6—C10—H10B	109.5
O3—S1—C1	108.06 (6)	H10A—C10—H10B	109.5
O2—S1—C13	108.05 (6)	C6—C10—H10C	109.5
O3—S1—C13	107.27 (6)	H10A—C10—H10C	109.5
C1—S1—C13	104.43 (6)	H10B—C10—H10C	109.5
C8—O1—C7	107.20 (11)	C8—C11—C12	113.00 (13)
C8—C1—C2	108.02 (12)	C8—C11—H11A	109.0
C8—C1—S1	127.10 (11)	C12—C11—H11A	109.0
C2—C1—S1	124.84 (10)	C8—C11—H11B	109.0
C7—C2—C3	119.68 (13)	C12—C11—H11B	109.0
C7—C2—C1	104.35 (12)	H11A—C11—H11B	107.8
C3—C2—C1	135.96 (13)	C11—C12—H12A	109.5
C4—C3—C2	118.14 (14)	C11—C12—H12B	109.5
C4—C3—H3	120.9	H12A—C12—H12B	109.5
C2—C3—H3	120.9	C11—C12—H12C	109.5
C3—C4—C5	119.77 (15)	H12A—C12—H12C	109.5
C3—C4—C9	120.17 (15)	H12B—C12—H12C	109.5
C5—C4—C9	120.05 (14)	C14—C13—C18	121.55 (13)
C6—C5—C4	123.62 (14)	C14—C13—S1	118.74 (10)
C6—C5—H5	118.2	C18—C13—S1	119.70 (10)
C4—C5—H5	118.2	C15—C14—C13	119.42 (13)
C7—C6—C5	114.32 (14)	C15—C14—H14	120.3
C7—C6—C10	122.25 (15)	C13—C14—H14	120.3
C5—C6—C10	123.43 (14)	C16—C15—C14	118.19 (13)
O1—C7—C6	125.00 (14)	C16—C15—H15	120.9
O1—C7—C2	110.53 (12)	C14—C15—H15	120.9
C6—C7—C2	124.47 (14)	F1—C16—C15	118.29 (14)
C1—C8—O1	109.89 (12)	F1—C16—C17	118.31 (14)
C1—C8—C11	135.05 (13)	C15—C16—C17	123.41 (14)
O1—C8—C11	115.06 (12)	C16—C17—C18	118.51 (13)
C4—C9—H9A	109.5	C16—C17—H17	120.7
C4—C9—H9B	109.5	C18—C17—H17	120.7
H9A—C9—H9B	109.5	C17—C18—C13	118.92 (13)
C4—C9—H9C	109.5	C17—C18—H18	120.5
H9A—C9—H9C	109.5	C13—C18—H18	120.5
H9B—C9—H9C	109.5

O2—S1—C1—C8	8.30 (15)	C3—C2—C7—C6	−0.5 (2)
O3—S1—C1—C8	139.05 (12)	C1—C2—C7—C6	179.20 (13)
C13—S1—C1—C8	−106.97 (13)	C2—C1—C8—O1	−0.30 (15)
O2—S1—C1—C2	−173.96 (10)	S1—C1—C8—O1	177.75 (9)
O3—S1—C1—C2	−43.20 (13)	C2—C1—C8—C11	−179.77 (15)
C13—S1—C1—C2	70.78 (12)	S1—C1—C8—C11	−1.7 (2)
C8—C1—C2—C7	0.46 (14)	C7—O1—C8—C1	0.01 (15)
S1—C1—C2—C7	−177.64 (10)	C7—O1—C8—C11	179.60 (11)
C8—C1—C2—C3	−179.96 (15)	C1—C8—C11—C12	95.6 (2)
S1—C1—C2—C3	1.9 (2)	O1—C8—C11—C12	−83.88 (16)
C7—C2—C3—C4	0.70 (19)	O2—S1—C13—C14	−38.40 (12)
C1—C2—C3—C4	−178.83 (14)	O3—S1—C13—C14	−167.95 (10)
C2—C3—C4—C5	−0.4 (2)	C1—S1—C13—C14	77.52 (12)
C2—C3—C4—C9	178.89 (13)	O2—S1—C13—C18	140.33 (11)
C3—C4—C5—C6	−0.1 (2)	O3—S1—C13—C18	10.79 (13)
C9—C4—C5—C6	−179.43 (14)	C1—S1—C13—C18	−103.75 (12)
C4—C5—C6—C7	0.4 (2)	C18—C13—C14—C15	0.6 (2)
C4—C5—C6—C10	179.40 (14)	S1—C13—C14—C15	179.36 (11)
C8—O1—C7—C6	−179.37 (13)	C13—C14—C15—C16	0.2 (2)
C8—O1—C7—C2	0.30 (15)	C14—C15—C16—F1	179.00 (13)
C5—C6—C7—O1	179.55 (12)	C14—C15—C16—C17	−1.0 (2)
C10—C6—C7—O1	0.5 (2)	F1—C16—C17—C18	−179.19 (13)
C5—C6—C7—C2	−0.1 (2)	C15—C16—C17—C18	0.8 (2)
C10—C6—C7—C2	−179.13 (13)	C16—C17—C18—C13	0.1 (2)
C3—C2—C7—O1	179.87 (11)	C14—C13—C18—C17	−0.8 (2)
C1—C2—C7—O1	−0.47 (14)	S1—C13—C18—C17	−179.53 (11)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C3—H3···O3ⁱ	0.95	2.55	3.4804 (18)	167
C14—H14···O2ⁱⁱ	0.95	2.49	3.1211 (17)	124
C18—H18···O3ⁱ	0.95	2.36	3.2742 (17)	160

Symmetry codes: (i) −x+1, −y+2, −z+1; (ii) −x+1, −y+2, −z.

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C3—H3···O3ⁱ	0.95	2.55	3.4804 (18)	167
C14—H14···O2ⁱⁱ	0.95	2.49	3.1211 (17)	124
C18—H18···O3ⁱ	0.95	2.36	3.2742 (17)	160

Symmetry codes: (i) −x+1, −y+2, −z+1; (ii) −x+1, −y+2, −z.

Experimental details

Crystal data
Chemical formula	C₁₈H₁₇FO₃S
M_r	332.38
Crystal system, space group	Triclinic, P1
Temperature (K)	173
a, b, c (Å)	8.8756 (2), 9.3917 (2), 11.0284 (2)
α, β, γ (°)	65.735 (1), 80.735 (1), 71.145 (1)
V (Å³)	792.68 (3)
Z	2
Radiation type	Mo Kα
µ (mm⁻¹)	0.23
Crystal size (mm)	0.39 × 0.33 × 0.30

Data collection
Diffractometer	Bruker SMART APEXII CCD diffractometer
Absorption correction	Multi-scan (SADABS; Bruker, 2009)
T_min, T_max	0.918, 0.936
No. of measured, independent and observed [I > 2σ(I)] reflections	14813, 3934, 3489
R_int	0.025
(sin θ/λ)_max (Å⁻¹)	0.668

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.037, 0.108, 1.07
No. of reflections	3934
No. of parameters	211
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.29, −0.44

Computer programs: APEX2 (Bruker, 2009), SAINT (Bruker, 2009), SHELXS97 (Sheldrick, 2008), ORTEP-3 for Windows (Farrugia, 2012) and DIAMOND (Brandenburg, 1998), SHELXL2014 (Sheldrick, 2008) and PLATON (Spek, 2009).

Acknowledgements

The X-ray centre of Gyeongsang National University is acknowledged for providing access to the single-crystal diffractometer.

References

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Volume 70| Part 10| October 2014| Pages 249-251

doi:10.1107/S1600536814019436

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research communications\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Crystal structure of 2-ethyl-3-(4-fluoro­phenyl­sulfon­yl)-5,7-di­methyl-1-benzo­furan

1. Chemical Context

2. Structural commentary

3. Supra­molecular features

4. Database survey

5. Synthesis and crystallization

6. Refinement

Supporting information

Acknowledgements

References

research communications

Crystal structure of 2-ethyl-3-(4-fluorophenylsulfonyl)-5,7-dimethyl-1-benzofuran

3. Supramolecular features