Crystal structure of zwitterionic 4-(ammonio­methyl)­benzoate: a simple mol­ecule giving rise to a complex supra­molecular structure

The asymmetric unit of the title compound, C₈H₉NO₂·H₂O consists of an isolated 4-(ammonio­meth­yl)benzoate zwitterion derived from 4-amino­methyl­benzoic acid through the migration of the acidic proton, together with a water molecule of crystallization that is disordered over three sites with occupancy ratios (0.50:0.35:0.15). In the crystal structure, N—H⋯O hydrogen bonds together with π–π stacking of the benzene rings [centroid–centroid distance = 3.8602 (18) Å] result in a strongly linked, compact three-dimensional structure.

1. Chemical context

As part of a long-range project to find new transition-metal complexes of simple ligands such as carboxyl­ates and amines, we have screened a number of derivatives of benzoic acid, in particular those that a search of the Cambridge Structural Database (CSD, Version 5.35, updated to May 2014; Groom & Allen, 2014) reveals to have formed few coordination complexes whose structures have been reported. The title compound was the unexpected product of an attempt to form a Co^II complex with 4-amino­methyl­benzoic acid [HAMBA, (a) in scheme below], which has no entries in the CSD, and di­amino­purine (DAP).

No coordination complex resulted, but the reaction provided, as an unexpected bonus, a crystalline phase of the monohydrate of the zwitterion of HAMBA (see scheme below), in which the acidic proton has migrated to the amino group resulting in COO⁻ and CH₂NH₃⁺ substituents on the aromatic ring and forming 4-(ammonio­meth­yl)benzoate [(b) in scheme above]. In contrast to the utmost simplicity of its mol­ecular structure, the zwitterion displays an extremely complex hydrogen-bonding scheme and concomitant supra­molecular structure as reported herein.

2. Structural commentary

Fig. 1 shows the asymmetric unit of the title compound, (I). The C—C₆—C backbone is essentially planar [maximum deviation of 0.005 (3) Å for C8], and subtends dihedral angles of 6.8 (2) and 83.9 (2)° with the O₂C–C (major disorder component) and C–CN planes, respectively. Bond lengths and angles are normal, with the C—O bond lengths of the carboxyl­ate group close to equal, indicating extensive electron delocalization over the unit [C7—O1: 1.266 (4), C7—O2: 1.262 (4) Å].

Figure 1 The asymmetric unit of (I). The minor disorder component of the carboxyl­ate group and those of the solvate water mol­ecule are drawn with broken lines.

3. Supra­molecular features

As indicated previously, the most inter­esting features in the structure are those derived from the inter­molecular inter­actions, presented in Table 1 (hydrogen bonds) and Table 2 (π–π contacts). Each ammonium group is bound through N—H⋯O hydrogen bonds to three different mol­ecules of (I), with the carboxyl­ato oxygen atoms as acceptors (Fig. 2a). In addition, the benzene rings stack almost parallel to each other in slanted columns (Fig. 2b). N1—H1A⋯O2 and N1—H1C⋯O1 hydrogen bonds link four mol­ecules together, generating R₄⁴(24) ring motifs, Fig. 3a, while a second synthon with an R₄³(10) graph set motif is generated through contacts involving all three hydrogens of the ammonium cation, Fig. 3b (for graph-set notation see, for example, Bernstein et al., 1995).

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1A⋯O2^i	1.07 (3)	1.75 (3)	2.804 (4)	170 (3)
N1—H1B⋯O1^ii	1.07 (3)	1.73 (4)	2.768 (3)	162 (4)
N1—H1C⋯O1^iii	1.07 (3)	1.87 (3)	2.901 (6)	161 (3)
Symmetry codes: (i) ; (ii) ; (iii) .

Table 2
π–π contacts (Å, °)

Cg1 is the centroid of atoms C1–C6. ccd is the centroid–centroid distance, da is the dihedral angle between rings and ipd is the inter­planar distance, or (mean) distance from one plane to the neighbouring centroid. For details, see Janiak (2000).

Group 1⋯Group 2	ccd	da	ipd
Cg1⋯Cg1^iii	3.8602 (18)	0.7 (2)	3.665 (5)
Symmetry code: (iii) x − , −y + 7/4, z + 1/4.

Figure 2 (a) Hydrogen-bonding and (b) π–π inter­actions in (I). Symmetry codes: (i) x − , −y + , z − ; (ii) −x + , y − , z − ; (iii) x − , −y + , z + ; (iv) x + , −y + , z − .

Figure 3 (a) R4^4(24) loops, A, formed by mol­ecules of (I) through N1—H1A⋯O2 and N1—H1C⋯O1 hydrogen bonds. (b) R4^3(10) loops, B, formed by mol­ecules of (I) through N—H⋯O contacts involving all three H atoms of the NH3^+ substituent.

The R₄⁴(24) synthons combine with the π–π stacking inter­actions to generate layers of mol­ecules in the ac plane. The π–π contacts are inclined parallel to either the (101) plane for one set of contacts (Fig. 4a) or the (01) plane for the other (Fig. 4b).

Figure 4 Sheets of mol­ecules of (I) in the ac plane linked by N—H⋯O hydrogen bonds (single dashed lines) and π–π inter­actions (double dashed lines).

Fig. 5 shows a view along the c axis, and reveals the `corrugated' shape of these sheets, consisting of zigzag chains of mol­ecules linked in a head-to-tail fashion and stacked roughly along the a-axis direction. Adjacent sheets are inter­connected along b in an obverse fashion by N1—H1B⋯O1 hydrogen bonds.

Figure 5 Chains of mol­ecules of (I) linked by N—H⋯O hydrogen bonds to form a three-dimensional network.

Finally, Fig. 6 presents a view approximately along the ac diagonal displaying the two hydrogen-bonding synthons, A and B, together with the π–π inter­actions and demonstrates how they combine to generate the three-dimensional network.

Figure 6 Overall packing for (I) showing how the A and B ring motifs combine with π–π stacking inter­actions to generate a three-dimensional network.

4. Database survey

Neither 4-(ammonio­meth­yl)benzoate nor its zwitterionic form described here appear in the CSD (Version 5.35, updated to May 2014). The most closely related structures are those of a zwitterionic form of 4-ammonio­methyl­cyclo­hexane-1-carb­oxy­lic acid (IIa) (Shahzadi et al., 2007; CSD refcode AMMCHC11) and its hemihydrated analogue (IIb) (Yamazaki et al., 1981; CSD refcode AMCHCA), in which the phenyl ring is replaced by cyclo­hexane. This introduces some obvious differences with (I), for π–π contacts are clearly precluded and there are different relative orientations of the hydrogen-bonding donors and acceptors. In spite of this, the hydrogen-bonding schemes do show some striking similarities, leading to similar (though differently connected) two-dimensional sub-structures. In particular, the same R₄⁴(24) and R₄³(10) synthons are present in both cases as in (I), and play predominant roles in the crystal packing. This is despite the presence of the water solvate in (IIb), which is not involved in classical hydrogen bonding to the zwitterion.

5. Synthesis and crystallization

To an aqueous solution of HAMBA (1 mmol, 0.15116g) were added an aqueous solution of Co(Ac)₂·4H₂O (2 mmol, 0.49816g) and an ethano­lic solution of DAP (1 mmol, 0.15009 g). The resulting mixture was heated at reflux for 4 h and left to cool down and evaporate at room temperature. After a few days, crystals suitable for X-ray diffraction of the (uncomplexed) zwitterion (I) appeared. These were used as grown.

6. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 3.

Table 3
Experimental details

Crystal data
Chemical formula	C8H9NO2·H2O
Mr	169.18
Crystal system, space group	Orthorhombic, Fdd2
Temperature (K)	297
a, b, c (Å)	13.743 (3), 38.302 (7), 6.2686 (11)
V (Å^3)	3299.7 (11)
Z	16
Radiation type	Mo Kα
μ (mm^−1)	0.11
Crystal size (mm)	0.48 × 0.30 × 0.22
Data collection
Diffractometer	Bruker SMART CCD area detector
Absorption correction	Multi-scan (SADABS; Bruker, 2002)
Tmin, Tmax	0.94, 0.98
No. of measured, independent and observed [I > 2σ(I)] reflections	6720, 1827, 1555
Rint	0.021
(sin θ/λ)max (Å^−1)	0.659
Refinement
R[F^2 > 2σ(F^2)], wR(F^2), S	0.046, 0.137, 1.04
No. of reflections	1827
No. of parameters	134
No. of restraints	13
H-atom treatment	H atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å^−3)	0.21, −0.18
Absolute structure	Flack x determined using 616 quotients [(I^+)−(I^−)]/[(I^+)+(I^−)] (Parsons & Flack, 2004)
Absolute structure parameter	−1.2 (4)
Computer programs: SMART (Bruker, 2001) and SAINT (Bruker, 2002), SHELXS97, SHELXL2014 and SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009).

There are two disorder features in this structure. The oxygen atoms of the carboxyl­ate group were disordered over two positions that were refined with similarity restraints with occupancy factors 0.912 (13)/0.088 (13). Disorder involving the water molecule was more pronounced, with the oxygen atoms disordered over three distinct sites. When refined, the occupancies appeared to be strongly correlated with their displacement factors, showing an oscillating behaviour. In the final refinement cycles, occupancies were fixed to the mean values of these oscillation ranges with occupancy ratios 0.50:0.35:0.15.

All the H atoms (except for those of the disordered water mol­ecules) were recognizable in an early difference Fourier map. Hydrogen atoms of the NH₃ group were refined with N—H distances restrained to be equal to within 0.01Å [final d(N—H) = 1.07 (3) Å]. All H atoms bound to carbon were refined using a riding model with d(C—H) = 0.93 Å and U_iso = 1.2U_eq(C) for aromatic and 0.98 Å, U_iso = 1.2U_eq(C) for methyl­ene H atoms. The hydrogen atoms on the disordered water solvate were not identified.

When trying to calculate the Flack parameter of the inverted structure, it was recognised that the space group was one of the few (seven, in fact) where the structure cannot be inverted by simple inversion of the atomic coordinates. In the case of Fdd2, the `inversion rule' to be applied is Inv(x, y, z) =  − x,  − y, −z, After this, the refinement proceeded smoothly without any change in the symmetry operators. Even so, the resulting Flack Parameters were both disparate and high [−1.2 (4) vs 2.2 (4) for the reported/inverted structures, respectively]. Hence, the absolute configuration could not be determined reliably.

Supporting information

S1. Chemical context

As part of a long-range project to find new transition-metal complexes of simple ligands such as carboxyl­ates and amines, we have screened a number of derivatives of benzoic acid, in particular those that a search of the Cambridge Structural Database (CSD, Version 5.35, updated to May 2014; Groom & Allen, 2014) reveals to have formed few coordination complexes whose structures have been reported. The title compound was the unexpected product of an attempt to form a Co^II complex with 4-amino­methyl­benzoic acid [HAMBA, (a) in scheme below], which has no entries in the CSD, and di­amino­purine (DAP).

No coordination complex resulted, but the reaction provided, as an unexpected bonus, a crystalline phase of the monohydrate of the zwitterion of HAMBA (see scheme below), in which the acidic proton has migrated to the amino group resulting in COO^- and CH₂NH₃⁺ substituents on the aromatic ring and forming 4-(ammonio­methyl)­benzoate [(b) in scheme above]. In contrast to the utmost simplicity of its molecular structure, the zwitterion displays an extremely complex hydrogen-bonding scheme and concomitant supra­molecular structure as reported herein.

S2. Structural commentary

Fig. 1 shows the asymmetric unit of the title compound, (I). The C—C₆—C backbone is planar [maximum deviation of 0.005 (3) Å for C8], and subtends dihedral angles of 6.8 (su?) and 83.9 (su?)° with the O₂C–C (major disorder component) and C–CN planes, respectively. Bond lengths and angles are normal, with the C—O bond lengths of the carboxyl­ate group close to equal, indicating extensive electron delocalization over the unit [C7—O1: 1.266 (4), C7—O2: 1.262 (4) Å].

S3. Supra­molecular features

As indicated previously, the most inter­esting features in the structure are those derived from the inter­molecular inter­actions, presented in Table 2 (hydrogen bonds) and Table 3 (π–π contacts). Each ammonium group is bound through N—H···O hydrogen bonds to three different molecules of (I), with the carboxyl­ato oxygens as acceptors (Fig 2a). In addition, the benzene rings stack almost parallel to each other in slanted columns (Fig. 2b). N1—H1A···O2 and N1—H1C···O1 hydrogen bonds link four molecules together, generating R⁴₄(24) ring motifs, Fig. 3a, while a second synthon with an R³₄(10) graph set motif is generated through contacts involving all three hydrogens of the ammonium cation, Fig 3b (for graph-set notation see, for example, Bernstein et al., 1995).

The R⁴₄(24) synthons combine with the π–π stacking inter­actions to generate layers of molecules in the ac plane. The π–π contacts are inclined parallel to either the (101) plane for one set of contacts (Fig. 4a) or the (101) plane for the other (Fig. 4b).

Fig. 5 shows a view along the c axis, and reveals the `corrugated' shape of these sheets, consisting of zigzag chains of molecules linked in a head-to-tail fashion and stacked roughly along the a-axis direction. Adjacent sheets are inter­connected along b in an obverse fashion by N1—H1B···O1 hydrogen bonds.

Finally, Fig 6 presents a view approximately along the ac diagonal displaying the two hydrogen-bonding synthons, A and B, together with the π–π inter­actions and demonstrates how they combine to generate the three-dimensional network.

S4. Database survey

Neither 4-(ammonio­methyl)­benzoate nor its zwitterionic form described here appear in the CSD (Version 5.35, updated to May 2014). The most closely related structures are those of a zwitterionic form of 4-ammonio­methyl­cyclo­hexane-1-carb­oxy­lic acid (IIa) (Shahzadi et al., 2007; CSD refcode AMMCHC11) and its hemihydrated analogue (IIb) (Yamazaki et al., 1981; CSD refcode AMCHCA), in which the phenyl ring is replaced by cyclo­hexane. This introduces some obvious differences with (I), for π–π contacts are clearly precluded and there are different relative orientations of the hydrogen-bonding donors and acceptors. In spite of this, the hydrogen-bonding schemes do show some striking similarities, leading to similar (though differently connected) two-dimensional sub-structures. In particular, the same R⁴₄(24) and R³₄(10) synthons are present in both cases as in (I), and play predominant roles in the crystal packing. This is despite the presence of the water solvate in (IIb), which is not involved in classical hydrogen bonding to the zwitterion.

S5. Synthesis and crystallization

To an aqueous solution of HAMBA (1 mmol, 0.15116g ) were added an aqueous solution of Co(Ac)₂·4H₂O ( 2 mmol, 0.49816g ) and an ethano­lic solution of DAP (1 mmol, 0.15009 g). The resulting mixture was heated at reflux for 4 hours and left to cool down and evaporate at room temperature. After a few days, crystals suitable for X-ray diffraction of the (uncomplexed) zwitterion (I) appeared. These were used as grown.

S6. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 3.

There are two disorder features in this structure. The oxygen atoms of the carboxyl­ate group were disordered over two positions that were refined with similarity restraints with occupancy factors 0.912 (13)/0.088 (13). Disorder involving the water solvate was more pronounced, with the oxygen atoms disordered over three distinct sites. When refined, the occupancies appeared to be strongly correlated with their displacement factors, showing an oscillating behaviour. In the final refinement cycles, occupancies were fixed to the mean values of these oscillation ranges with occupancy ratios 0.50:0.35:0.15.

All the H atoms (except for those of the disordered water molecules) were recognizable in an early difference Fourier map. Hydrogen atoms of the NH₃ group were refined with N—H distances restrained to be equal to within 0.01Å [final d(N—H) = 1.07 (3) Å]. All H atoms bound to carbon were refined using a riding model with d(C—H) = 0.93 Å and U_iso = 1.2U_eq(C) for aromatic and 0.98 Å, U_iso = 1.2U_eq(C) for methyl­ene H atoms. The hydrogen atoms on the disordered water solvate were not identified.

When trying to calculate the Flack parameter of the inverted structure, it was recognised that the space group was one of the few (seven, in fact) where the structure cannot be inverted by simple inversion of the atomic coordinates. In the case of Fdd2, the `inversion rule' to be applied is Inv(x,y,z) = 0.25-x, 0.25-y,-z, After this, the refinement proceeded smoothly without any change in the symmetry operators. Even so, the resulting Flack Parameters were both disparate and high [-1.2 (4) vs 2.2 (4) for the reported/inverted structures, respectively]. Hence, the absolute configuration could not be determined reliably.

Related literature

For related literature, see: Groom & Allen (2014); Bernstein et al. (1995); Shahzadi et al. (2007); Yamazaki et al. (1981).

Computing details

Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2002); data reduction: SAINT (Bruker, 2002); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL2014 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009).

Figures

The asymmetric unit of (I). The minor disorder component of the carboxylate group and those of the solvate water molecule are drawn with broken lines.

(a) Hydrogen-bonding and (b) π–π interactions in (I). Symmetry codes: (i) x - 1/4, -y + 7/4, z - 3/4; (ii) -x + 5/4, y - 1/4, z - 1/4; (iii) x - 1/4, -y + 7/4, z + 1/4; (iv) x + 1/4,-y + 7/4,z - 1/4.

(a) R⁴₄(24) loops, A, formed by molecules of (I) through N1—H1A···O2 and N1—H1C···O1 hydrogen bonds. (b) R³₄(10) loops, B, formed by molecules of (I) through N—H···O contacts involving all three H atoms of the NH₃⁺ substituent.

Sheets of molecules of (I) in the ac plane linked by N—H···O hydrogen bonds (single dashed lines) and π–π interactions (double dashed lines).

Chains of molecules of (I) linked by N—H···O hydrogen bonds to form a three-dimensional network.

Overall packing for (I) showing how the A and B ring motifs combine with π–π stacking interactions to generate a three-dimensional network.

4-(Ammoniomethyl)benzoate

Crystal data

C8H9NO2·H2O	Dx = 1.362 Mg m^−3
Mr = 169.18	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, Fdd2	Cell parameters from 1680 reflections
a = 13.743 (3) Å	θ = 3.1–26.1°
b = 38.302 (7) Å	µ = 0.11 mm^−1
c = 6.2686 (11) Å	T = 297 K
V = 3299.7 (11) Å^3	Block, pale pink
Z = 16	0.48 × 0.30 × 0.22 mm
F(000) = 1440

Data collection

Bruker SMART CCD area detector diffractometer	1555 reflections with I > 2σ(I)
CCD rotation images, thin slices scans	Rint = 0.021
Absorption correction: multi-scan (SADABS; Bruker, 2002)	θmax = 27.9°, θmin = 2.1°
Tmin = 0.94, Tmax = 0.98	h = −16→18
6720 measured reflections	k = −48→47
1827 independent reflections	l = −8→8

Refinement

Refinement on F^2	Hydrogen site location: mixed
Least-squares matrix: full	H atoms treated by a mixture of independent and constrained refinement
R[F^2 > 2σ(F^2)] = 0.046	w = 1/[σ^2(Fo^2) + (0.0839P)^2 + 1.177P] where P = (Fo^2 + 2Fc^2)/3
wR(F^2) = 0.137	(Δ/σ)max < 0.001
S = 1.04	Δρmax = 0.21 e Å^−3
1827 reflections	Δρmin = −0.18 e Å^−3
134 parameters	Absolute structure: Flack x determined using 616 quotients [(I^+)-(I^-)]/[(I^+)+(I^-)] (Parsons & Flack, 2004)
13 restraints	Absolute structure parameter: −1.2 (4)

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq	Occ. (<1)
O1	0.6801 (4)	0.96039 (6)	0.9009 (5)	0.0628 (10)	0.912 (13)
O2	0.6899 (4)	0.94439 (9)	1.2429 (5)	0.0759 (12)	0.912 (13)
O1A	0.641 (3)	0.9615 (6)	0.946 (6)	0.0628 (10)	0.088 (13)
O2A	0.736 (3)	0.9413 (8)	1.210 (5)	0.0759 (12)	0.088 (13)
C1	0.67898 (18)	0.89967 (7)	0.9810 (4)	0.0461 (6)
C2	0.6919 (2)	0.87399 (7)	1.1326 (5)	0.0579 (7)
H2	0.7033	0.8802	1.2738	0.069*
C3	0.6881 (2)	0.83912 (7)	1.0764 (6)	0.0620 (8)
H3	0.6974	0.8221	1.1800	0.074*
C4	0.6705 (2)	0.82944 (6)	0.8686 (5)	0.0507 (7)
C5	0.6570 (2)	0.85503 (7)	0.7172 (5)	0.0584 (7)
H5	0.6449	0.8488	0.5764	0.070*
C6	0.6612 (2)	0.89013 (7)	0.7727 (5)	0.0538 (7)
H6	0.6521	0.9072	0.6691	0.065*
C7	0.68372 (16)	0.93753 (7)	1.0465 (5)	0.0546 (7)
C8	0.6665 (2)	0.79104 (7)	0.8069 (7)	0.0653 (9)
H8A	0.6956	0.7880	0.6672	0.078*
H8B	0.7040	0.7775	0.9085	0.078*
N1	0.5655 (2)	0.77823 (6)	0.8030 (5)	0.0576 (6)
H1A	0.524 (2)	0.7907 (12)	0.682 (7)	0.131 (18)*
H1B	0.5636 (19)	0.7506 (9)	0.776 (8)	0.119 (16)*
H1C	0.529 (2)	0.7830 (10)	0.951 (6)	0.16 (2)*
O1WA	0.6665 (7)	0.73276 (19)	0.2872 (17)	0.100 (2)	0.5
O1WB	0.6438 (12)	0.7488 (3)	0.244 (3)	0.100 (2)	0.35
O1WC	0.647 (2)	0.7552 (7)	0.323 (5)	0.100 (2)	0.15

Atomic displacement parameters (Ų)

	U^11	U^22	U^33	U^12	U^13	U^23
O1	0.088 (3)	0.0314 (9)	0.0690 (15)	−0.0019 (11)	0.0092 (15)	−0.0041 (10)
O2	0.107 (3)	0.0553 (14)	0.0655 (15)	−0.0144 (17)	−0.0026 (16)	−0.0195 (12)
O1A	0.088 (3)	0.0314 (9)	0.0690 (15)	−0.0019 (11)	0.0092 (15)	−0.0041 (10)
O2A	0.107 (3)	0.0553 (14)	0.0655 (15)	−0.0144 (17)	−0.0026 (16)	−0.0195 (12)
C1	0.0512 (14)	0.0333 (12)	0.0537 (15)	−0.0039 (9)	0.0023 (11)	−0.0037 (10)
C2	0.0784 (19)	0.0426 (14)	0.0526 (16)	−0.0071 (13)	−0.0054 (16)	−0.0023 (12)
C3	0.0843 (19)	0.0379 (13)	0.0638 (19)	−0.0031 (14)	−0.0036 (14)	0.0076 (13)
C4	0.0527 (13)	0.0296 (11)	0.0697 (17)	−0.0005 (10)	0.0082 (12)	−0.0056 (12)
C5	0.083 (2)	0.0411 (14)	0.0511 (15)	−0.0050 (13)	0.0033 (14)	−0.0103 (12)
C6	0.0757 (18)	0.0318 (12)	0.0538 (16)	−0.0001 (11)	−0.0040 (13)	−0.0002 (11)
C7	0.0639 (16)	0.0372 (13)	0.0626 (18)	−0.0062 (11)	0.0025 (13)	−0.0113 (13)
C8	0.0710 (18)	0.0320 (12)	0.093 (2)	0.0035 (12)	0.0091 (17)	−0.0108 (14)
N1	0.0777 (15)	0.0303 (10)	0.0648 (15)	−0.0039 (10)	−0.0015 (12)	−0.0033 (11)
O1WA	0.102 (4)	0.086 (5)	0.110 (6)	−0.028 (5)	0.013 (4)	−0.009 (5)
O1WB	0.102 (4)	0.086 (5)	0.110 (6)	−0.028 (5)	0.013 (4)	−0.009 (5)
O1WC	0.102 (4)	0.086 (5)	0.110 (6)	−0.028 (5)	0.013 (4)	−0.009 (5)

Geometric parameters (Å, º)

O1—C7	1.266 (4)	C4—C5	1.377 (4)
O2—C7	1.262 (4)	C4—C8	1.521 (4)
O1A—C7	1.259 (13)	C5—C6	1.390 (4)
O2A—C7	1.256 (13)	C5—H5	0.9300
C1—C6	1.378 (4)	C6—H6	0.9300
C1—C2	1.379 (4)	C8—N1	1.472 (4)
C1—C7	1.509 (4)	C8—H8A	0.9700
C2—C3	1.382 (4)	C8—H8B	0.9700
C2—H2	0.9300	N1—H1A	1.07 (3)
C3—C4	1.376 (5)	N1—H1B	1.07 (3)
C3—H3	0.9300	N1—H1C	1.07 (3)
C6—C1—C2	119.1 (2)	O2A—C7—O1A	126.0 (16)
C6—C1—C7	121.4 (2)	O2—C7—O1	124.2 (3)
C2—C1—C7	119.5 (3)	O2A—C7—C1	111.0 (15)
C1—C2—C3	120.6 (3)	O1A—C7—C1	123.0 (14)
C1—C2—H2	119.7	O2—C7—C1	118.0 (3)
C3—C2—H2	119.7	O1—C7—C1	117.8 (3)
C4—C3—C2	120.6 (3)	N1—C8—C4	111.1 (2)
C4—C3—H3	119.7	N1—C8—H8A	109.4
C2—C3—H3	119.7	C4—C8—H8A	109.4
C3—C4—C5	119.0 (2)	N1—C8—H8B	109.4
C3—C4—C8	120.5 (3)	C4—C8—H8B	109.4
C5—C4—C8	120.5 (3)	H8A—C8—H8B	108.0
C4—C5—C6	120.7 (3)	C8—N1—H1A	111.9 (15)
C4—C5—H5	119.6	C8—N1—H1B	110.8 (15)
C6—C5—H5	119.6	H1A—N1—H1B	109 (4)
C1—C6—C5	120.1 (3)	C8—N1—H1C	111.6 (16)
C1—C6—H6	120.0	H1A—N1—H1C	107 (2)
C5—C6—H6	120.0	H1B—N1—H1C	107 (2)

Hydrogen-bond geometry (Å, º)

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1A···O2^i	1.07 (3)	1.75 (3)	2.804 (4)	170 (3)
N1—H1B···O1^ii	1.07 (3)	1.73 (4)	2.768 (3)	162 (4)
N1—H1C···O1^iii	1.07 (3)	1.87 (3)	2.901 (6)	161 (3)

Symmetry codes: (i) x−1/4, −y+7/4, z−3/4; (ii) −x+5/4, y−1/4, z−1/4; (iii) x−1/4, −y+7/4, z+1/4.