organic compounds
N-deacetyllappaconitine
ofaXi'an Botanical Garden, Institute of Botany of Shaanxi Province, Xi'an 710061, People's Republic of China
*Correspondence e-mail: sxw@ms.xab.ac.cn
The title compound, C30H42N2O7 [systematic name: (1S,4S,5S,7S,8S,9S,10S,11S,13R,14S,16S,17R)-20-ethyl-4,8,9-trihydroxy-1,14,16-trimethoxyaconitan-4-yl 2-aminobenzoate], isolated from roots of Aconitum sinomontanum Nakai, is a typical aconitane-type C19-diterpenoid alkaloid, which crystallizes with two independent molecules in the The conformations of the two independent molecules are closely similar. Each molecule comprises four six-membered rings (A, B, D and E) including one six-membered N-containing heterocyclic ring (E), and two five-membered rings (C and F). Rings A, B and E adopt chair conformations, while ring D displays a boat conformation. Five-membered rings C and F exhibit envelope conformations. IntramolecularN—H⋯O hydrogen bonds between the amino group and carbonyl O atom help to stabilize molecular structure. In the crystal, O—H⋯O hydrogen bonds link the molecules into zigzag chains propagating in [010].
Keywords: N-deacetyllappaconitine; C19-diterpenoid alkaloid; O—H⋯O hydrogen bonding.; crystal structure.
CCDC reference: 1409115
1. Related literature
For reviews of typical C19-diterpenoid see: Wang et al. (2009, 2010). For the isolation, idenfication and biological activity of N-deacetyllappaconitine, see: Peng et al. (2000); Romanov et al. (2008). For ring numbering, ring conformations and absolute configurations of C19-diterpenoid see: Wang et al. (2007); He et al. (2008).
2. Experimental
2.1. Crystal data
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2.3. Refinement
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Data collection: SMART (Bruker, 2002); cell SAINT; data reduction: SAINT (Bruker, 2002); program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL and Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXTL.
Supporting information
CCDC reference: 1409115
https://doi.org/10.1107/S2056989015012335/cv5490sup1.cif
contains datablocks I, New_Global_Publ_Block. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989015012335/cv5490Isup2.hkl
Supporting information file. DOI: https://doi.org/10.1107/S2056989015012335/cv5490Isup4.cdx
The title compound, N-deacetyllappaconitine, is produced by several species of the plant genus Aconitum (A. sinomontanum, A. barbatum, A. septentrionale, A. leucostomum, A. orientale) and its structure was confirmed by the NMR and MS data. It possesses antiarrhythmic, analgesic, local anesthetic, sedative and anti-inflammatory activity (Peng et al. 2000; Wang et al. 2009, 2010; Romanov et al. 2008). Herewith we present the
of N-deacetyllappaconitine (I).The title compound (I) crystallizes with two independent molecules in the
(Fig. 1). The confomations of both molecules are close (Fig. 2) due to intramolecular N—H···O and O—H···O hydrogen bonds (Table 1). Each molecule is composed from six rings labelled as A-F (Wang et al., 2007). Six-membered rings A (C1–C5/C11) and B (C7–C11/C17) adopt chair conformations; six-membered N-containing heterocyclic ring E (C4/C5/C11/C17/N2/C18) display the same chair conformation; the five-membered rings C (C9/C10/C12/C13/C14) and F (C5/C6/C7/C17/C11) form envelope conformations, in which, atoms C13 and C17, respectively, play the role of flap. The six-membered ring D (C8/C9/C14/C13/C16/C15) is in a boat conformation.In the crystal, intermolecular O—H···O hydrogen bonds (Table 1) link the molecules into zigzag chains propagated in [010] .
The title compound was isolated from the roots of Aconitum sinomontanum Nakai following the known procedure (Peng et al., 2000). Colourless single crystals suitable for X-ray diffraction were obtained by slow evaporation from a methanol solution for two weeks at the room temperacture.
The hydrogen atoms were placed in calculated positions and refined as riding with Uiso(H) =1.2–1.5 Ueq (C, O). The positions of methyl and hydroxy hydrogens were rotationally optimized. In spite of acceptable value of
of -0.07 (15) in the abscence of anomalous scatterers, the of the title compound has been assigned to be the same as that reported for typical natural aconitane-type C19-diterpenoid (Wang et al., 2007; He et al., 2008).The title compound, N-deacetyllappaconitine, is produced by several species of the plant genus Aconitum (A. sinomontanum, A. barbatum, A. septentrionale, A. leucostomum, A. orientale) and its structure was confirmed by the NMR and MS data. It possesses antiarrhythmic, analgesic, local anesthetic, sedative and anti-inflammatory activity (Peng et al. 2000; Wang et al. 2009, 2010; Romanov et al. 2008). Herewith we present the
of N-deacetyllappaconitine (I).The title compound (I) crystallizes with two independent molecules in the
(Fig. 1). The confomations of both molecules are close (Fig. 2) due to intramolecular N—H···O and O—H···O hydrogen bonds (Table 1). Each molecule is composed from six rings labelled as A-F (Wang et al., 2007). Six-membered rings A (C1–C5/C11) and B (C7–C11/C17) adopt chair conformations; six-membered N-containing heterocyclic ring E (C4/C5/C11/C17/N2/C18) display the same chair conformation; the five-membered rings C (C9/C10/C12/C13/C14) and F (C5/C6/C7/C17/C11) form envelope conformations, in which, atoms C13 and C17, respectively, play the role of flap. The six-membered ring D (C8/C9/C14/C13/C16/C15) is in a boat conformation.In the crystal, intermolecular O—H···O hydrogen bonds (Table 1) link the molecules into zigzag chains propagated in [010] .
The title compound was isolated from the roots of Aconitum sinomontanum Nakai following the known procedure (Peng et al., 2000). Colourless single crystals suitable for X-ray diffraction were obtained by slow evaporation from a methanol solution for two weeks at the room temperacture.
For reviews of typical C19-diterpenoid
see: Wang et al. (2009, 2010). For the isolation, idenfication and biological activity of N-deacetyllappaconitine, see: Peng et al. (2000); Romanov et al. (2008). For ring numbering, ring conformations and absolute configurations of C19-diterpenoid see: Wang et al. (2007); He et al. (2008). detailsThe hydrogen atoms were placed in calculated positions and refined as riding with Uiso(H) =1.2–1.5 Ueq (C, O). The positions of methyl and hydroxy hydrogens were rotationally optimized. In spite of acceptable value of
of -0.07 (15) in the abscence of anomalous scatterers, the of the title compound has been assigned to be the same as that reported for typical natural aconitane-type C19-diterpenoid (Wang et al., 2007; He et al., 2008).Data collection: SMART (Bruker, 2002); cell
SAINT (Bruker, 2002); data reduction: SAINT (Bruker, 2002); program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008) and Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).Fig. 1. Two independent molecules in the asymmetric unit showing the atomic labeling and 30% probabilty displacement ellipsoids. H atoms omitted for clarity. | |
Fig. 2. The overlay of two independent molecules. |
C30H42N2O7 | F(000) = 2336 |
Mr = 542.66 | Dx = 1.305 Mg m−3 |
Orthorhombic, P212121 | Cu Kα radiation, λ = 1.54184 Å |
Hall symbol: P 2ac 2ab | Cell parameters from 7732 reflections |
a = 11.7090 (3) Å | θ = 3.6–66.9° |
b = 13.2040 (4) Å | µ = 0.75 mm−1 |
c = 35.7380 (9) Å | T = 173 K |
V = 5525.3 (3) Å3 | Prism, colourless |
Z = 8 | 0.30 × 0.30 × 0.30 mm |
Bruker SMART CCD area-detector diffractometer | 8477 independent reflections |
Radiation source: fine-focus sealed tube | 7744 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.030 |
phi and ω scans | θmax = 65.0°, θmin = 2.5° |
Absorption correction: multi-scan (SADABS; Bruker, 2002) | h = −13→13 |
Tmin = 0.806, Tmax = 0.806 | k = −12→15 |
18595 measured reflections | l = −42→38 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.042 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.111 | H-atom parameters constrained |
S = 1.02 | w = 1/[σ2(Fo2) + (0.0677P)2 + 0.5213P] where P = (Fo2 + 2Fc2)/3 |
8477 reflections | (Δ/σ)max = 0.001 |
713 parameters | Δρmax = 0.26 e Å−3 |
0 restraints | Δρmin = −0.19 e Å−3 |
C30H42N2O7 | V = 5525.3 (3) Å3 |
Mr = 542.66 | Z = 8 |
Orthorhombic, P212121 | Cu Kα radiation |
a = 11.7090 (3) Å | µ = 0.75 mm−1 |
b = 13.2040 (4) Å | T = 173 K |
c = 35.7380 (9) Å | 0.30 × 0.30 × 0.30 mm |
Bruker SMART CCD area-detector diffractometer | 8477 independent reflections |
Absorption correction: multi-scan (SADABS; Bruker, 2002) | 7744 reflections with I > 2σ(I) |
Tmin = 0.806, Tmax = 0.806 | Rint = 0.030 |
18595 measured reflections |
R[F2 > 2σ(F2)] = 0.042 | 0 restraints |
wR(F2) = 0.111 | H-atom parameters constrained |
S = 1.02 | Δρmax = 0.26 e Å−3 |
8477 reflections | Δρmin = −0.19 e Å−3 |
713 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
C1 | 0.2568 (2) | 0.43649 (19) | 0.54143 (6) | 0.0422 (6) | |
H1 | 0.3404 | 0.4330 | 0.5358 | 0.051* | |
C2 | 0.2385 (2) | 0.3917 (2) | 0.58046 (6) | 0.0505 (6) | |
H2A | 0.3022 | 0.4132 | 0.5968 | 0.061* | |
H2B | 0.1671 | 0.4198 | 0.5911 | 0.061* | |
C3 | 0.2312 (2) | 0.2773 (2) | 0.58093 (7) | 0.0527 (7) | |
H3A | 0.3069 | 0.2479 | 0.5751 | 0.063* | |
H3B | 0.2081 | 0.2538 | 0.6061 | 0.063* | |
C4 | 0.1451 (2) | 0.24306 (19) | 0.55241 (6) | 0.0401 (5) | |
C5 | 0.1853 (2) | 0.26898 (18) | 0.51258 (6) | 0.0359 (5) | |
H5 | 0.2602 | 0.2362 | 0.5067 | 0.043* | |
C6 | 0.0911 (2) | 0.23517 (18) | 0.48488 (6) | 0.0388 (5) | |
H6A | 0.1250 | 0.2038 | 0.4623 | 0.047* | |
H6B | 0.0387 | 0.1860 | 0.4968 | 0.047* | |
C7 | 0.02808 (19) | 0.33336 (18) | 0.47485 (6) | 0.0364 (5) | |
H7 | −0.0564 | 0.3221 | 0.4754 | 0.044* | |
C8 | 0.06474 (19) | 0.37144 (19) | 0.43617 (6) | 0.0380 (5) | |
C9 | 0.19841 (18) | 0.37717 (18) | 0.43412 (6) | 0.0362 (5) | |
C10 | 0.25048 (19) | 0.41825 (18) | 0.47103 (6) | 0.0369 (5) | |
H10 | 0.3308 | 0.3927 | 0.4721 | 0.044* | |
C11 | 0.19213 (18) | 0.38589 (18) | 0.50856 (6) | 0.0342 (5) | |
C12 | 0.2580 (3) | 0.5349 (2) | 0.46378 (7) | 0.0541 (7) | |
H12A | 0.2160 | 0.5725 | 0.4834 | 0.065* | |
H12B | 0.3387 | 0.5574 | 0.4640 | 0.065* | |
C13 | 0.2039 (2) | 0.5545 (2) | 0.42508 (7) | 0.0503 (6) | |
H13 | 0.2413 | 0.6133 | 0.4124 | 0.060* | |
C14 | 0.2339 (2) | 0.4561 (2) | 0.40577 (6) | 0.0454 (6) | |
H14 | 0.3185 | 0.4527 | 0.4022 | 0.054* | |
C15 | 0.0062 (2) | 0.4726 (2) | 0.42595 (7) | 0.0480 (6) | |
H15A | −0.0228 | 0.4664 | 0.4000 | 0.058* | |
H15B | −0.0612 | 0.4803 | 0.4424 | 0.058* | |
C16 | 0.0749 (3) | 0.5707 (2) | 0.42826 (7) | 0.0531 (7) | |
H16 | 0.0586 | 0.6035 | 0.4529 | 0.064* | |
C17 | 0.06348 (18) | 0.40758 (17) | 0.50614 (6) | 0.0336 (5) | |
H17 | 0.0497 | 0.4792 | 0.4982 | 0.040* | |
C18 | 0.0243 (2) | 0.28618 (19) | 0.55827 (7) | 0.0415 (5) | |
H18A | −0.0319 | 0.2410 | 0.5460 | 0.050* | |
H18B | 0.0070 | 0.2875 | 0.5854 | 0.050* | |
C19 | 0.0950 (2) | 0.0736 (2) | 0.57788 (7) | 0.0531 (7) | |
C20 | 0.3107 (4) | 0.6053 (3) | 0.55720 (12) | 0.0920 (12) | |
H20A | 0.3241 | 0.5891 | 0.5836 | 0.138* | |
H20B | 0.2859 | 0.6760 | 0.5550 | 0.138* | |
H20C | 0.3814 | 0.5956 | 0.5430 | 0.138* | |
C21 | −0.0699 (4) | 0.6774 (3) | 0.40392 (12) | 0.1110 (17) | |
H21A | −0.1243 | 0.6210 | 0.4037 | 0.167* | |
H21B | −0.0878 | 0.7241 | 0.3834 | 0.167* | |
H21C | −0.0751 | 0.7133 | 0.4278 | 0.167* | |
C22 | 0.2309 (3) | 0.4802 (3) | 0.34001 (8) | 0.0855 (11) | |
H22A | 0.2215 | 0.5538 | 0.3417 | 0.128* | |
H22B | 0.1949 | 0.4556 | 0.3170 | 0.128* | |
H22C | 0.3124 | 0.4635 | 0.3396 | 0.128* | |
C23 | −0.1048 (2) | 0.4258 (2) | 0.54681 (7) | 0.0426 (5) | |
H23A | −0.1374 | 0.4002 | 0.5706 | 0.051* | |
H23B | −0.1514 | 0.3981 | 0.5261 | 0.051* | |
C24 | −0.1135 (3) | 0.5397 (2) | 0.54635 (9) | 0.0624 (8) | |
H24A | −0.0592 | 0.5682 | 0.5644 | 0.094* | |
H24B | −0.1912 | 0.5600 | 0.5532 | 0.094* | |
H24C | −0.0957 | 0.5648 | 0.5212 | 0.094* | |
C25 | 0.39217 (18) | 0.08850 (16) | 0.71788 (6) | 0.0320 (5) | |
H25 | 0.4767 | 0.0942 | 0.7212 | 0.038* | |
C26 | 0.3616 (2) | 0.14105 (18) | 0.68090 (6) | 0.0408 (5) | |
H26A | 0.4200 | 0.1237 | 0.6619 | 0.049* | |
H26B | 0.2873 | 0.1148 | 0.6720 | 0.049* | |
C27 | 0.3544 (2) | 0.25473 (18) | 0.68429 (6) | 0.0399 (5) | |
H27A | 0.3261 | 0.2841 | 0.6605 | 0.048* | |
H27B | 0.4311 | 0.2831 | 0.6894 | 0.048* | |
C28 | 0.27342 (18) | 0.28149 (16) | 0.71598 (6) | 0.0313 (5) | |
C29 | 0.32419 (18) | 0.24848 (16) | 0.75345 (6) | 0.0309 (4) | |
H29 | 0.3994 | 0.2820 | 0.7582 | 0.037* | |
C30 | 0.2373 (2) | 0.27287 (16) | 0.78494 (6) | 0.0364 (5) | |
H30A | 0.2768 | 0.3006 | 0.8072 | 0.044* | |
H30B | 0.1802 | 0.3228 | 0.7762 | 0.044* | |
C31 | 0.18008 (18) | 0.17164 (16) | 0.79424 (6) | 0.0334 (5) | |
H31 | 0.0956 | 0.1804 | 0.7967 | 0.040* | |
C32 | 0.22999 (19) | 0.12554 (17) | 0.83008 (6) | 0.0350 (5) | |
C33 | 0.36444 (19) | 0.12486 (17) | 0.82810 (6) | 0.0338 (5) | |
C34 | 0.40731 (17) | 0.09500 (16) | 0.78846 (6) | 0.0312 (4) | |
H34 | 0.4846 | 0.1263 | 0.7856 | 0.037* | |
C35 | 0.33562 (16) | 0.13118 (15) | 0.75396 (5) | 0.0272 (4) | |
C36 | 0.42728 (19) | −0.02177 (18) | 0.79183 (6) | 0.0383 (5) | |
H36A | 0.3865 | −0.0580 | 0.7716 | 0.046* | |
H36B | 0.5097 | −0.0376 | 0.7900 | 0.046* | |
C37 | 0.38056 (19) | −0.05397 (17) | 0.83042 (6) | 0.0361 (5) | |
H37 | 0.4222 | −0.1147 | 0.8401 | 0.043* | |
C38 | 0.41089 (19) | 0.03980 (18) | 0.85266 (6) | 0.0369 (5) | |
H38 | 0.4959 | 0.0458 | 0.8539 | 0.044* | |
C39 | 0.17956 (19) | 0.01971 (18) | 0.83848 (6) | 0.0391 (5) | |
H39A | 0.1624 | 0.0166 | 0.8656 | 0.047* | |
H39B | 0.1059 | 0.0142 | 0.8250 | 0.047* | |
C40 | 0.2514 (2) | −0.07378 (17) | 0.82849 (6) | 0.0366 (5) | |
H40 | 0.2319 | −0.0947 | 0.8024 | 0.044* | |
C41 | 0.20902 (16) | 0.10515 (16) | 0.75957 (6) | 0.0284 (4) | |
H41 | 0.1999 | 0.0317 | 0.7657 | 0.034* | |
C42 | 0.15309 (19) | 0.23520 (17) | 0.71190 (6) | 0.0367 (5) | |
H42A | 0.0981 | 0.2770 | 0.7262 | 0.044* | |
H42B | 0.1304 | 0.2374 | 0.6852 | 0.044* | |
C43 | 0.21456 (19) | 0.45045 (17) | 0.69410 (6) | 0.0368 (5) | |
C44 | 0.4515 (3) | −0.0713 (2) | 0.69438 (9) | 0.0706 (9) | |
H44A | 0.4605 | −0.0428 | 0.6692 | 0.106* | |
H44B | 0.4286 | −0.1425 | 0.6924 | 0.106* | |
H44C | 0.5242 | −0.0667 | 0.7079 | 0.106* | |
C45 | 0.4057 (3) | −0.0248 (2) | 0.91444 (7) | 0.0575 (7) | |
H45A | 0.3667 | −0.0890 | 0.9092 | 0.086* | |
H45B | 0.3901 | −0.0041 | 0.9403 | 0.086* | |
H45C | 0.4882 | −0.0337 | 0.9110 | 0.086* | |
C46 | 0.1203 (2) | −0.2031 (2) | 0.84451 (8) | 0.0578 (7) | |
H46A | 0.0578 | −0.1553 | 0.8490 | 0.087* | |
H46B | 0.1102 | −0.2630 | 0.8604 | 0.087* | |
H46C | 0.1200 | −0.2236 | 0.8182 | 0.087* | |
C47 | 0.02761 (19) | 0.09681 (19) | 0.72501 (7) | 0.0428 (6) | |
H47A | −0.0084 | 0.1189 | 0.7013 | 0.051* | |
H47B | −0.0132 | 0.1307 | 0.7458 | 0.051* | |
C48 | 0.0124 (2) | −0.0161 (2) | 0.72891 (10) | 0.0645 (8) | |
H48A | 0.0617 | −0.0509 | 0.7109 | 0.097* | |
H48B | −0.0675 | −0.0339 | 0.7241 | 0.097* | |
H48C | 0.0332 | −0.0368 | 0.7543 | 0.097* | |
C1' | 0.0897 (2) | −0.0336 (2) | 0.56605 (8) | 0.0553 (7) | |
C2' | 0.0381 (2) | −0.1087 (3) | 0.58835 (9) | 0.0642 (8) | |
C3' | 0.0275 (3) | −0.2063 (3) | 0.57384 (13) | 0.0817 (11) | |
H3' | −0.0092 | −0.2571 | 0.5883 | 0.098* | |
C4' | 0.0689 (4) | −0.2303 (3) | 0.53928 (13) | 0.0997 (14) | |
H4' | 0.0612 | −0.2974 | 0.5300 | 0.120* | |
C5' | 0.1214 (5) | −0.1580 (3) | 0.51803 (12) | 0.1061 (15) | |
H5' | 0.1517 | −0.1752 | 0.4942 | 0.127* | |
C6' | 0.1303 (4) | −0.0612 (3) | 0.53097 (9) | 0.0766 (10) | |
H6' | 0.1653 | −0.0114 | 0.5156 | 0.092* | |
C1'' | 0.22222 (19) | 0.55868 (17) | 0.70302 (6) | 0.0365 (5) | |
C2'' | 0.1771 (3) | 0.6321 (2) | 0.67866 (8) | 0.0542 (7) | |
C3'' | 0.1854 (3) | 0.7340 (2) | 0.68911 (10) | 0.0672 (9) | |
H3'' | 0.1571 | 0.7846 | 0.6727 | 0.081* | |
C4'' | 0.2335 (3) | 0.7625 (2) | 0.72248 (10) | 0.0643 (8) | |
H4'' | 0.2361 | 0.8321 | 0.7292 | 0.077* | |
C5'' | 0.2778 (2) | 0.6908 (2) | 0.74615 (8) | 0.0548 (7) | |
H5'' | 0.3122 | 0.7106 | 0.7691 | 0.066* | |
C6'' | 0.2721 (2) | 0.59137 (19) | 0.73669 (7) | 0.0429 (5) | |
H6'' | 0.3029 | 0.5424 | 0.7533 | 0.051* | |
N1 | −0.0034 (3) | −0.0889 (3) | 0.62340 (8) | 0.0928 (10) | |
H1A | 0.0242 | −0.0281 | 0.6312 | 0.111* | |
H1B | 0.0201 | −0.1384 | 0.6394 | 0.111* | |
N2 | 0.01194 (16) | 0.38839 (15) | 0.54309 (5) | 0.0373 (4) | |
N3 | 0.1290 (3) | 0.6066 (2) | 0.64485 (7) | 0.0889 (10) | |
H3C | 0.0735 | 0.6526 | 0.6394 | 0.107* | |
H3D | 0.0974 | 0.5438 | 0.6467 | 0.107* | |
N4 | 0.14633 (14) | 0.13030 (14) | 0.72516 (5) | 0.0328 (4) | |
O1 | 0.0612 (2) | 0.10686 (18) | 0.60764 (5) | 0.0740 (6) | |
O2 | 0.14170 (17) | 0.13201 (13) | 0.55120 (4) | 0.0500 (4) | |
O3 | 0.24945 (15) | 0.28229 (13) | 0.42563 (4) | 0.0443 (4) | |
H3 | 0.2200 | 0.2586 | 0.4061 | 0.066* | |
O4 | 0.02651 (16) | 0.29539 (14) | 0.41009 (5) | 0.0487 (4) | |
H4 | 0.0438 | 0.3130 | 0.3882 | 0.073* | |
O5 | 0.17912 (16) | 0.43398 (15) | 0.37103 (4) | 0.0538 (5) | |
O6 | 0.0426 (2) | 0.63931 (16) | 0.39921 (6) | 0.0710 (6) | |
O7 | 0.22516 (17) | 0.54113 (14) | 0.54284 (5) | 0.0554 (5) | |
O8 | 0.16607 (18) | 0.41487 (13) | 0.66696 (5) | 0.0538 (5) | |
O9 | 0.26648 (14) | 0.39190 (11) | 0.71983 (4) | 0.0373 (3) | |
O10 | 0.36612 (14) | −0.01612 (12) | 0.71417 (4) | 0.0407 (4) | |
O11 | 0.19519 (16) | 0.19342 (13) | 0.85988 (4) | 0.0490 (4) | |
H11 | 0.2113 | 0.1673 | 0.8806 | 0.059* | |
O12 | 0.36556 (16) | 0.05052 (14) | 0.88956 (4) | 0.0481 (4) | |
O13 | 0.22545 (14) | −0.15629 (13) | 0.85308 (4) | 0.0448 (4) | |
O14 | 0.41392 (15) | 0.21944 (12) | 0.83770 (4) | 0.0441 (4) | |
H14A | 0.3753 | 0.2467 | 0.8599 | 0.053* |
U11 | U22 | U33 | U12 | U13 | U23 | |
C1 | 0.0410 (12) | 0.0460 (14) | 0.0396 (12) | −0.0053 (11) | −0.0029 (10) | −0.0089 (11) |
C2 | 0.0540 (14) | 0.0645 (18) | 0.0329 (12) | −0.0067 (14) | −0.0057 (11) | −0.0124 (12) |
C3 | 0.0592 (15) | 0.0672 (19) | 0.0317 (12) | 0.0090 (14) | −0.0042 (11) | 0.0023 (12) |
C4 | 0.0501 (13) | 0.0397 (14) | 0.0304 (11) | 0.0055 (11) | 0.0030 (10) | 0.0013 (10) |
C5 | 0.0430 (11) | 0.0346 (13) | 0.0300 (10) | 0.0044 (10) | 0.0022 (9) | −0.0028 (9) |
C6 | 0.0528 (13) | 0.0309 (12) | 0.0328 (11) | −0.0056 (11) | 0.0021 (10) | −0.0010 (9) |
C7 | 0.0375 (11) | 0.0377 (13) | 0.0339 (11) | −0.0049 (10) | 0.0020 (9) | −0.0020 (10) |
C8 | 0.0419 (12) | 0.0401 (14) | 0.0319 (11) | 0.0001 (10) | −0.0036 (9) | 0.0001 (10) |
C9 | 0.0404 (11) | 0.0365 (13) | 0.0318 (11) | 0.0025 (10) | 0.0049 (9) | −0.0010 (9) |
C10 | 0.0363 (11) | 0.0398 (13) | 0.0346 (11) | −0.0016 (10) | 0.0037 (9) | −0.0031 (10) |
C11 | 0.0359 (10) | 0.0376 (13) | 0.0290 (10) | 0.0020 (10) | 0.0004 (9) | −0.0028 (9) |
C12 | 0.0649 (16) | 0.0497 (16) | 0.0476 (14) | −0.0161 (14) | 0.0096 (13) | −0.0014 (13) |
C13 | 0.0678 (16) | 0.0390 (14) | 0.0440 (13) | −0.0073 (13) | 0.0152 (12) | 0.0097 (11) |
C14 | 0.0482 (12) | 0.0507 (15) | 0.0373 (12) | 0.0017 (12) | 0.0070 (10) | 0.0046 (11) |
C15 | 0.0514 (13) | 0.0521 (16) | 0.0403 (13) | 0.0120 (12) | 0.0034 (11) | 0.0064 (12) |
C16 | 0.0776 (18) | 0.0401 (14) | 0.0415 (13) | 0.0126 (14) | 0.0174 (13) | 0.0076 (11) |
C17 | 0.0403 (11) | 0.0304 (12) | 0.0302 (10) | 0.0013 (9) | 0.0027 (9) | −0.0005 (9) |
C18 | 0.0490 (13) | 0.0394 (14) | 0.0359 (12) | 0.0039 (11) | 0.0088 (10) | 0.0037 (10) |
C19 | 0.0596 (15) | 0.0547 (17) | 0.0449 (14) | 0.0114 (14) | 0.0035 (12) | 0.0175 (13) |
C20 | 0.107 (3) | 0.060 (2) | 0.109 (3) | −0.020 (2) | −0.031 (2) | −0.026 (2) |
C21 | 0.126 (3) | 0.095 (3) | 0.112 (3) | 0.070 (3) | 0.051 (3) | 0.049 (3) |
C22 | 0.096 (2) | 0.120 (3) | 0.0402 (15) | 0.004 (2) | 0.0096 (16) | 0.0289 (18) |
C23 | 0.0408 (11) | 0.0427 (14) | 0.0443 (12) | −0.0018 (11) | 0.0094 (10) | −0.0046 (11) |
C24 | 0.0607 (16) | 0.0464 (17) | 0.080 (2) | 0.0064 (14) | 0.0222 (15) | −0.0036 (15) |
C25 | 0.0344 (10) | 0.0266 (11) | 0.0352 (11) | −0.0008 (9) | 0.0069 (9) | −0.0022 (9) |
C26 | 0.0531 (13) | 0.0394 (13) | 0.0300 (11) | −0.0009 (11) | 0.0092 (10) | −0.0009 (10) |
C27 | 0.0517 (13) | 0.0338 (13) | 0.0341 (11) | −0.0029 (11) | 0.0052 (10) | 0.0083 (10) |
C28 | 0.0401 (11) | 0.0230 (11) | 0.0309 (10) | −0.0018 (9) | −0.0039 (9) | 0.0014 (8) |
C29 | 0.0367 (10) | 0.0242 (11) | 0.0317 (10) | −0.0015 (9) | −0.0028 (9) | −0.0022 (9) |
C30 | 0.0543 (13) | 0.0243 (11) | 0.0308 (10) | 0.0111 (10) | −0.0008 (10) | −0.0002 (9) |
C31 | 0.0354 (10) | 0.0297 (12) | 0.0351 (11) | 0.0092 (9) | 0.0042 (9) | 0.0005 (9) |
C32 | 0.0416 (11) | 0.0325 (12) | 0.0309 (10) | 0.0075 (10) | 0.0079 (9) | 0.0010 (9) |
C33 | 0.0409 (11) | 0.0282 (12) | 0.0324 (11) | −0.0012 (10) | −0.0019 (9) | −0.0016 (9) |
C34 | 0.0307 (9) | 0.0291 (12) | 0.0338 (11) | 0.0006 (9) | 0.0024 (8) | 0.0009 (9) |
C35 | 0.0304 (9) | 0.0233 (11) | 0.0278 (10) | −0.0007 (8) | 0.0010 (8) | −0.0006 (8) |
C36 | 0.0427 (11) | 0.0337 (12) | 0.0386 (12) | 0.0092 (10) | 0.0065 (10) | 0.0072 (10) |
C37 | 0.0418 (12) | 0.0299 (12) | 0.0367 (11) | 0.0070 (10) | 0.0006 (9) | 0.0087 (9) |
C38 | 0.0355 (10) | 0.0406 (13) | 0.0347 (11) | 0.0011 (10) | −0.0011 (9) | 0.0046 (10) |
C39 | 0.0363 (10) | 0.0428 (14) | 0.0382 (12) | 0.0029 (10) | 0.0061 (9) | 0.0104 (10) |
C40 | 0.0452 (12) | 0.0309 (12) | 0.0337 (11) | −0.0005 (10) | −0.0017 (9) | 0.0065 (9) |
C41 | 0.0306 (10) | 0.0224 (10) | 0.0323 (10) | 0.0010 (8) | 0.0027 (8) | 0.0026 (8) |
C42 | 0.0416 (11) | 0.0313 (12) | 0.0372 (11) | 0.0007 (10) | −0.0066 (9) | 0.0037 (10) |
C43 | 0.0458 (12) | 0.0311 (12) | 0.0335 (11) | −0.0012 (10) | 0.0023 (9) | 0.0058 (9) |
C44 | 0.098 (2) | 0.0424 (16) | 0.0711 (19) | 0.0198 (17) | 0.0277 (18) | −0.0096 (14) |
C45 | 0.0682 (16) | 0.0618 (18) | 0.0424 (13) | 0.0017 (15) | −0.0074 (12) | 0.0179 (13) |
C46 | 0.0608 (16) | 0.0573 (18) | 0.0553 (15) | −0.0205 (15) | −0.0011 (13) | 0.0116 (13) |
C47 | 0.0357 (11) | 0.0384 (14) | 0.0543 (14) | −0.0030 (10) | −0.0076 (10) | 0.0064 (11) |
C48 | 0.0518 (15) | 0.0461 (17) | 0.095 (2) | −0.0143 (13) | −0.0165 (15) | 0.0080 (16) |
C1' | 0.0630 (15) | 0.0443 (16) | 0.0587 (16) | 0.0072 (14) | 0.0055 (13) | 0.0178 (13) |
C2' | 0.0569 (15) | 0.064 (2) | 0.0711 (19) | 0.0147 (16) | 0.0082 (14) | 0.0300 (16) |
C3' | 0.078 (2) | 0.049 (2) | 0.118 (3) | −0.0027 (17) | 0.004 (2) | 0.032 (2) |
C4' | 0.128 (4) | 0.054 (2) | 0.117 (3) | −0.021 (2) | 0.021 (3) | −0.001 (2) |
C5' | 0.168 (4) | 0.050 (2) | 0.101 (3) | −0.022 (3) | 0.044 (3) | −0.010 (2) |
C6' | 0.106 (3) | 0.054 (2) | 0.070 (2) | −0.010 (2) | 0.0229 (19) | 0.0025 (16) |
C1'' | 0.0412 (11) | 0.0269 (12) | 0.0413 (12) | 0.0021 (10) | 0.0055 (10) | 0.0039 (9) |
C2'' | 0.0719 (17) | 0.0382 (15) | 0.0524 (15) | 0.0052 (14) | −0.0059 (13) | 0.0087 (12) |
C3'' | 0.089 (2) | 0.0286 (14) | 0.083 (2) | 0.0108 (15) | −0.0110 (18) | 0.0108 (14) |
C4'' | 0.0712 (18) | 0.0291 (14) | 0.093 (2) | 0.0004 (14) | −0.0004 (17) | −0.0093 (15) |
C5'' | 0.0589 (15) | 0.0367 (14) | 0.0689 (17) | −0.0007 (13) | −0.0072 (14) | −0.0109 (13) |
C6'' | 0.0450 (12) | 0.0373 (14) | 0.0463 (13) | 0.0005 (11) | 0.0011 (10) | −0.0011 (11) |
N1 | 0.115 (2) | 0.087 (2) | 0.0763 (19) | 0.014 (2) | 0.0178 (18) | 0.0409 (18) |
N2 | 0.0414 (10) | 0.0371 (11) | 0.0335 (9) | 0.0000 (9) | 0.0076 (8) | −0.0006 (8) |
N3 | 0.145 (3) | 0.0551 (16) | 0.0664 (16) | 0.0170 (19) | −0.0368 (18) | 0.0142 (14) |
N4 | 0.0334 (8) | 0.0272 (10) | 0.0378 (9) | −0.0026 (8) | −0.0044 (7) | 0.0050 (8) |
O1 | 0.1100 (17) | 0.0679 (14) | 0.0440 (10) | 0.0173 (14) | 0.0202 (11) | 0.0133 (10) |
O2 | 0.0732 (11) | 0.0378 (10) | 0.0391 (9) | 0.0081 (9) | 0.0077 (8) | 0.0060 (7) |
O3 | 0.0529 (9) | 0.0415 (10) | 0.0384 (8) | 0.0108 (8) | 0.0026 (7) | −0.0044 (7) |
O4 | 0.0586 (10) | 0.0535 (11) | 0.0339 (8) | −0.0027 (9) | −0.0060 (8) | −0.0057 (8) |
O5 | 0.0633 (11) | 0.0652 (12) | 0.0329 (8) | 0.0044 (10) | 0.0075 (8) | 0.0056 (8) |
O6 | 0.0880 (14) | 0.0576 (13) | 0.0673 (12) | 0.0311 (12) | 0.0275 (11) | 0.0269 (10) |
O7 | 0.0685 (11) | 0.0434 (11) | 0.0543 (10) | −0.0052 (9) | −0.0096 (9) | −0.0171 (9) |
O8 | 0.0842 (13) | 0.0365 (9) | 0.0406 (9) | 0.0002 (9) | −0.0173 (9) | 0.0018 (8) |
O9 | 0.0536 (9) | 0.0210 (7) | 0.0374 (8) | 0.0001 (7) | −0.0058 (7) | 0.0033 (6) |
O10 | 0.0546 (9) | 0.0263 (8) | 0.0411 (8) | 0.0031 (7) | 0.0062 (8) | −0.0068 (7) |
O11 | 0.0695 (11) | 0.0457 (10) | 0.0319 (8) | 0.0154 (9) | 0.0094 (8) | −0.0014 (7) |
O12 | 0.0626 (10) | 0.0508 (11) | 0.0309 (8) | 0.0075 (9) | −0.0024 (7) | 0.0074 (7) |
O13 | 0.0534 (9) | 0.0359 (9) | 0.0452 (9) | −0.0099 (8) | −0.0054 (8) | 0.0136 (7) |
O14 | 0.0593 (10) | 0.0344 (9) | 0.0387 (8) | −0.0057 (8) | −0.0036 (8) | −0.0029 (7) |
C1—O7 | 1.431 (3) | C29—H29 | 1.0000 |
C1—C2 | 1.530 (3) | C30—C31 | 1.532 (3) |
C1—C11 | 1.549 (3) | C30—H30A | 0.9900 |
C1—H1 | 1.0000 | C30—H30B | 0.9900 |
C2—C3 | 1.512 (4) | C31—C32 | 1.534 (3) |
C2—H2A | 0.9900 | C31—C41 | 1.556 (3) |
C2—H2B | 0.9900 | C31—H31 | 1.0000 |
C3—C4 | 1.504 (3) | C32—O11 | 1.450 (3) |
C3—H3A | 0.9900 | C32—C39 | 1.546 (3) |
C3—H3B | 0.9900 | C32—C33 | 1.576 (3) |
C4—O2 | 1.467 (3) | C33—O14 | 1.419 (3) |
C4—C5 | 1.538 (3) | C33—C38 | 1.526 (3) |
C4—C18 | 1.539 (3) | C33—C34 | 1.554 (3) |
C5—C6 | 1.548 (3) | C34—C36 | 1.564 (3) |
C5—C11 | 1.552 (3) | C34—C35 | 1.566 (3) |
C5—H5 | 1.0000 | C34—H34 | 1.0000 |
C6—C7 | 1.534 (3) | C35—C41 | 1.535 (3) |
C6—H6A | 0.9900 | C36—C37 | 1.543 (3) |
C6—H6B | 0.9900 | C36—H36A | 0.9900 |
C7—C8 | 1.532 (3) | C36—H36B | 0.9900 |
C7—C17 | 1.544 (3) | C37—C38 | 1.514 (3) |
C7—H7 | 1.0000 | C37—C40 | 1.536 (3) |
C8—O4 | 1.441 (3) | C37—H37 | 1.0000 |
C8—C15 | 1.546 (3) | C38—O12 | 1.429 (3) |
C8—C9 | 1.569 (3) | C38—H38 | 1.0000 |
C9—O3 | 1.421 (3) | C39—C40 | 1.536 (3) |
C9—C14 | 1.511 (3) | C39—H39A | 0.9900 |
C9—C10 | 1.551 (3) | C39—H39B | 0.9900 |
C10—C12 | 1.565 (3) | C40—O13 | 1.432 (3) |
C10—C11 | 1.565 (3) | C40—H40 | 1.0000 |
C10—H10 | 1.0000 | C41—N4 | 1.470 (3) |
C11—C17 | 1.536 (3) | C41—H41 | 1.0000 |
C12—C13 | 1.543 (4) | C42—N4 | 1.466 (3) |
C12—H12A | 0.9900 | C42—H42A | 0.9900 |
C12—H12B | 0.9900 | C42—H42B | 0.9900 |
C13—C14 | 1.513 (4) | C43—O8 | 1.218 (3) |
C13—C16 | 1.530 (4) | C43—O9 | 1.346 (3) |
C13—H13 | 1.0000 | C43—C1'' | 1.467 (3) |
C14—O5 | 1.427 (3) | C44—O10 | 1.425 (3) |
C14—H14 | 1.0000 | C44—H44A | 0.9800 |
C15—C16 | 1.526 (4) | C44—H44B | 0.9800 |
C15—H15A | 0.9900 | C44—H44C | 0.9800 |
C15—H15B | 0.9900 | C45—O12 | 1.415 (3) |
C16—O6 | 1.429 (3) | C45—H45A | 0.9800 |
C16—H16 | 1.0000 | C45—H45B | 0.9800 |
C17—N2 | 1.474 (3) | C45—H45C | 0.9800 |
C17—H17 | 1.0000 | C46—O13 | 1.411 (3) |
C18—N2 | 1.462 (3) | C46—H46A | 0.9800 |
C18—H18A | 0.9900 | C46—H46B | 0.9800 |
C18—H18B | 0.9900 | C46—H46C | 0.9800 |
C19—O1 | 1.217 (3) | C47—N4 | 1.459 (3) |
C19—O2 | 1.343 (3) | C47—C48 | 1.507 (4) |
C19—C1' | 1.478 (4) | C47—H47A | 0.9900 |
C20—O7 | 1.409 (4) | C47—H47B | 0.9900 |
C20—H20A | 0.9800 | C48—H48A | 0.9800 |
C20—H20B | 0.9800 | C48—H48B | 0.9800 |
C20—H20C | 0.9800 | C48—H48C | 0.9800 |
C21—O6 | 1.419 (4) | C1'—C6' | 1.390 (4) |
C21—H21A | 0.9800 | C1'—C2' | 1.408 (4) |
C21—H21B | 0.9800 | C2'—N1 | 1.368 (4) |
C21—H21C | 0.9800 | C2'—C3' | 1.395 (5) |
C22—O5 | 1.403 (3) | C3'—C4' | 1.364 (6) |
C22—H22A | 0.9800 | C3'—H3' | 0.9500 |
C22—H22B | 0.9800 | C4'—C5' | 1.366 (5) |
C22—H22C | 0.9800 | C4'—H4' | 0.9500 |
C23—N2 | 1.460 (3) | C5'—C6' | 1.363 (5) |
C23—C24 | 1.508 (4) | C5'—H5' | 0.9500 |
C23—H23A | 0.9900 | C6'—H6' | 0.9500 |
C23—H23B | 0.9900 | C1''—C6'' | 1.405 (3) |
C24—H24A | 0.9800 | C1''—C2'' | 1.406 (3) |
C24—H24B | 0.9800 | C2''—N3 | 1.375 (4) |
C24—H24C | 0.9800 | C2''—C3'' | 1.400 (4) |
C25—O10 | 1.421 (3) | C3''—C4'' | 1.372 (4) |
C25—C26 | 1.535 (3) | C3''—H3'' | 0.9500 |
C25—C35 | 1.555 (3) | C4''—C5'' | 1.372 (4) |
C25—H25 | 1.0000 | C4''—H4'' | 0.9500 |
C26—C27 | 1.508 (3) | C5''—C6'' | 1.357 (3) |
C26—H26A | 0.9900 | C5''—H5'' | 0.9500 |
C26—H26B | 0.9900 | C6''—H6'' | 0.9500 |
C27—C28 | 1.519 (3) | N1—H1A | 0.9100 |
C27—H27A | 0.9900 | N1—H1B | 0.9100 |
C27—H27B | 0.9900 | N3—H3C | 0.9100 |
C28—O9 | 1.467 (2) | N3—H3D | 0.9100 |
C28—C29 | 1.528 (3) | O3—H3 | 0.8400 |
C28—C42 | 1.543 (3) | O4—H4 | 0.8400 |
C29—C30 | 1.551 (3) | O11—H11 | 0.8400 |
C29—C35 | 1.555 (3) | O14—H14A | 0.9800 |
O7—C1—C2 | 107.8 (2) | C31—C30—C29 | 105.27 (17) |
O7—C1—C11 | 108.43 (19) | C31—C30—H30A | 110.7 |
C2—C1—C11 | 117.1 (2) | C29—C30—H30A | 110.7 |
O7—C1—H1 | 107.7 | C31—C30—H30B | 110.7 |
C2—C1—H1 | 107.7 | C29—C30—H30B | 110.7 |
C11—C1—H1 | 107.7 | H30A—C30—H30B | 108.8 |
C3—C2—C1 | 113.8 (2) | C30—C31—C32 | 111.15 (18) |
C3—C2—H2A | 108.8 | C30—C31—C41 | 102.96 (16) |
C1—C2—H2A | 108.8 | C32—C31—C41 | 110.98 (16) |
C3—C2—H2B | 108.8 | C30—C31—H31 | 110.5 |
C1—C2—H2B | 108.8 | C32—C31—H31 | 110.5 |
H2A—C2—H2B | 107.7 | C41—C31—H31 | 110.5 |
C4—C3—C2 | 109.3 (2) | O11—C32—C31 | 105.12 (17) |
C4—C3—H3A | 109.8 | O11—C32—C39 | 107.97 (17) |
C2—C3—H3A | 109.8 | C31—C32—C39 | 112.04 (19) |
C4—C3—H3B | 109.8 | O11—C32—C33 | 108.49 (19) |
C2—C3—H3B | 109.8 | C31—C32—C33 | 110.21 (17) |
H3A—C3—H3B | 108.3 | C39—C32—C33 | 112.65 (18) |
O2—C4—C3 | 109.8 (2) | O14—C33—C38 | 111.30 (17) |
O2—C4—C5 | 101.74 (18) | O14—C33—C34 | 108.18 (17) |
C3—C4—C5 | 110.8 (2) | C38—C33—C34 | 102.86 (17) |
O2—C4—C18 | 110.4 (2) | O14—C33—C32 | 113.09 (19) |
C3—C4—C18 | 114.4 (2) | C38—C33—C32 | 109.54 (18) |
C5—C4—C18 | 108.98 (19) | C34—C33—C32 | 111.41 (17) |
C4—C5—C6 | 108.03 (19) | C33—C34—C36 | 103.19 (17) |
C4—C5—C11 | 108.83 (18) | C33—C34—C35 | 117.85 (16) |
C6—C5—C11 | 105.32 (17) | C36—C34—C35 | 116.19 (18) |
C4—C5—H5 | 111.5 | C33—C34—H34 | 106.2 |
C6—C5—H5 | 111.5 | C36—C34—H34 | 106.2 |
C11—C5—H5 | 111.5 | C35—C34—H34 | 106.2 |
C7—C6—C5 | 104.39 (17) | C41—C35—C29 | 98.14 (16) |
C7—C6—H6A | 110.9 | C41—C35—C25 | 116.01 (17) |
C5—C6—H6A | 110.9 | C29—C35—C25 | 112.82 (16) |
C7—C6—H6B | 110.9 | C41—C35—C34 | 110.27 (16) |
C5—C6—H6B | 110.9 | C29—C35—C34 | 111.05 (16) |
H6A—C6—H6B | 108.9 | C25—C35—C34 | 108.30 (16) |
C8—C7—C6 | 110.69 (18) | C37—C36—C34 | 106.70 (18) |
C8—C7—C17 | 111.72 (18) | C37—C36—H36A | 110.4 |
C6—C7—C17 | 103.77 (17) | C34—C36—H36A | 110.4 |
C8—C7—H7 | 110.2 | C37—C36—H36B | 110.4 |
C6—C7—H7 | 110.2 | C34—C36—H36B | 110.4 |
C17—C7—H7 | 110.2 | H36A—C36—H36B | 108.6 |
O4—C8—C7 | 105.52 (18) | C38—C37—C40 | 113.19 (19) |
O4—C8—C15 | 108.17 (18) | C38—C37—C36 | 99.25 (18) |
C7—C8—C15 | 111.87 (19) | C40—C37—C36 | 110.85 (18) |
O4—C8—C9 | 108.27 (19) | C38—C37—H37 | 111.0 |
C7—C8—C9 | 109.72 (18) | C40—C37—H37 | 111.0 |
C15—C8—C9 | 112.9 (2) | C36—C37—H37 | 111.0 |
O3—C9—C14 | 110.43 (18) | O12—C38—C37 | 118.60 (19) |
O3—C9—C10 | 108.94 (18) | O12—C38—C33 | 109.01 (18) |
C14—C9—C10 | 102.78 (19) | C37—C38—C33 | 102.50 (17) |
O3—C9—C8 | 112.8 (2) | O12—C38—H38 | 108.8 |
C14—C9—C8 | 109.8 (2) | C37—C38—H38 | 108.8 |
C10—C9—C8 | 111.68 (17) | C33—C38—H38 | 108.8 |
C9—C10—C12 | 103.03 (19) | C40—C39—C32 | 118.16 (18) |
C9—C10—C11 | 117.51 (18) | C40—C39—H39A | 107.8 |
C12—C10—C11 | 115.81 (19) | C32—C39—H39A | 107.8 |
C9—C10—H10 | 106.6 | C40—C39—H39B | 107.8 |
C12—C10—H10 | 106.6 | C32—C39—H39B | 107.8 |
C11—C10—H10 | 106.6 | H39A—C39—H39B | 107.1 |
C17—C11—C1 | 116.23 (18) | O13—C40—C39 | 110.64 (18) |
C17—C11—C5 | 98.06 (18) | O13—C40—C37 | 108.11 (18) |
C1—C11—C5 | 112.57 (18) | C39—C40—C37 | 113.07 (19) |
C17—C11—C10 | 109.21 (17) | O13—C40—H40 | 108.3 |
C1—C11—C10 | 108.58 (18) | C39—C40—H40 | 108.3 |
C5—C11—C10 | 111.92 (18) | C37—C40—H40 | 108.3 |
C13—C12—C10 | 106.9 (2) | N4—C41—C35 | 108.80 (16) |
C13—C12—H12A | 110.3 | N4—C41—C31 | 115.46 (16) |
C10—C12—H12A | 110.3 | C35—C41—C31 | 100.84 (16) |
C13—C12—H12B | 110.3 | N4—C41—H41 | 110.4 |
C10—C12—H12B | 110.3 | C35—C41—H41 | 110.4 |
H12A—C12—H12B | 108.6 | C31—C41—H41 | 110.4 |
C14—C13—C16 | 112.5 (2) | N4—C42—C28 | 113.15 (17) |
C14—C13—C12 | 99.8 (2) | N4—C42—H42A | 108.9 |
C16—C13—C12 | 111.2 (2) | C28—C42—H42A | 108.9 |
C14—C13—H13 | 111.0 | N4—C42—H42B | 108.9 |
C16—C13—H13 | 111.0 | C28—C42—H42B | 108.9 |
C12—C13—H13 | 111.0 | H42A—C42—H42B | 107.8 |
O5—C14—C9 | 108.6 (2) | O8—C43—O9 | 122.2 (2) |
O5—C14—C13 | 117.9 (2) | O8—C43—C1'' | 125.3 (2) |
C9—C14—C13 | 102.86 (19) | O9—C43—C1'' | 112.53 (19) |
O5—C14—H14 | 109.0 | O10—C44—H44A | 109.5 |
C9—C14—H14 | 109.0 | O10—C44—H44B | 109.5 |
C13—C14—H14 | 109.0 | H44A—C44—H44B | 109.5 |
C16—C15—C8 | 119.1 (2) | O10—C44—H44C | 109.5 |
C16—C15—H15A | 107.5 | H44A—C44—H44C | 109.5 |
C8—C15—H15A | 107.5 | H44B—C44—H44C | 109.5 |
C16—C15—H15B | 107.5 | O12—C45—H45A | 109.5 |
C8—C15—H15B | 107.5 | O12—C45—H45B | 109.5 |
H15A—C15—H15B | 107.0 | H45A—C45—H45B | 109.5 |
O6—C16—C15 | 111.0 (2) | O12—C45—H45C | 109.5 |
O6—C16—C13 | 107.2 (2) | H45A—C45—H45C | 109.5 |
C15—C16—C13 | 113.5 (2) | H45B—C45—H45C | 109.5 |
O6—C16—H16 | 108.3 | O13—C46—H46A | 109.5 |
C15—C16—H16 | 108.3 | O13—C46—H46B | 109.5 |
C13—C16—H16 | 108.3 | H46A—C46—H46B | 109.5 |
N2—C17—C11 | 108.60 (17) | O13—C46—H46C | 109.5 |
N2—C17—C7 | 115.47 (18) | H46A—C46—H46C | 109.5 |
C11—C17—C7 | 100.71 (17) | H46B—C46—H46C | 109.5 |
N2—C17—H17 | 110.5 | N4—C47—C48 | 114.3 (2) |
C11—C17—H17 | 110.5 | N4—C47—H47A | 108.7 |
C7—C17—H17 | 110.5 | C48—C47—H47A | 108.7 |
N2—C18—C4 | 112.4 (2) | N4—C47—H47B | 108.7 |
N2—C18—H18A | 109.1 | C48—C47—H47B | 108.7 |
C4—C18—H18A | 109.1 | H47A—C47—H47B | 107.6 |
N2—C18—H18B | 109.1 | C47—C48—H48A | 109.5 |
C4—C18—H18B | 109.1 | C47—C48—H48B | 109.5 |
H18A—C18—H18B | 107.8 | H48A—C48—H48B | 109.5 |
O1—C19—O2 | 123.0 (3) | C47—C48—H48C | 109.5 |
O1—C19—C1' | 125.6 (3) | H48A—C48—H48C | 109.5 |
O2—C19—C1' | 111.4 (2) | H48B—C48—H48C | 109.5 |
O7—C20—H20A | 109.5 | C6'—C1'—C2' | 118.2 (3) |
O7—C20—H20B | 109.5 | C6'—C1'—C19 | 119.7 (3) |
H20A—C20—H20B | 109.5 | C2'—C1'—C19 | 122.0 (3) |
O7—C20—H20C | 109.5 | N1—C2'—C3' | 119.0 (3) |
H20A—C20—H20C | 109.5 | N1—C2'—C1' | 122.4 (3) |
H20B—C20—H20C | 109.5 | C3'—C2'—C1' | 118.6 (3) |
O6—C21—H21A | 109.5 | C4'—C3'—C2' | 121.3 (3) |
O6—C21—H21B | 109.5 | C4'—C3'—H3' | 119.3 |
H21A—C21—H21B | 109.5 | C2'—C3'—H3' | 119.3 |
O6—C21—H21C | 109.5 | C3'—C4'—C5' | 120.0 (4) |
H21A—C21—H21C | 109.5 | C3'—C4'—H4' | 120.0 |
H21B—C21—H21C | 109.5 | C5'—C4'—H4' | 120.0 |
O5—C22—H22A | 109.5 | C6'—C5'—C4' | 120.1 (4) |
O5—C22—H22B | 109.5 | C6'—C5'—H5' | 120.0 |
H22A—C22—H22B | 109.5 | C4'—C5'—H5' | 120.0 |
O5—C22—H22C | 109.5 | C5'—C6'—C1' | 121.7 (3) |
H22A—C22—H22C | 109.5 | C5'—C6'—H6' | 119.1 |
H22B—C22—H22C | 109.5 | C1'—C6'—H6' | 119.1 |
N2—C23—C24 | 113.5 (2) | C6''—C1''—C2'' | 118.3 (2) |
N2—C23—H23A | 108.9 | C6''—C1''—C43 | 120.7 (2) |
C24—C23—H23A | 108.9 | C2''—C1''—C43 | 120.9 (2) |
N2—C23—H23B | 108.9 | N3—C2''—C3'' | 119.9 (3) |
C24—C23—H23B | 108.9 | N3—C2''—C1'' | 122.0 (3) |
H23A—C23—H23B | 107.7 | C3''—C2''—C1'' | 118.1 (3) |
C23—C24—H24A | 109.5 | C4''—C3''—C2'' | 121.7 (3) |
C23—C24—H24B | 109.5 | C4''—C3''—H3'' | 119.2 |
H24A—C24—H24B | 109.5 | C2''—C3''—H3'' | 119.2 |
C23—C24—H24C | 109.5 | C3''—C4''—C5'' | 120.1 (3) |
H24A—C24—H24C | 109.5 | C3''—C4''—H4'' | 120.0 |
H24B—C24—H24C | 109.5 | C5''—C4''—H4'' | 120.0 |
O10—C25—C26 | 108.00 (17) | C6''—C5''—C4'' | 119.7 (3) |
O10—C25—C35 | 109.78 (16) | C6''—C5''—H5'' | 120.1 |
C26—C25—C35 | 116.81 (17) | C4''—C5''—H5'' | 120.1 |
O10—C25—H25 | 107.3 | C5''—C6''—C1'' | 122.1 (2) |
C26—C25—H25 | 107.3 | C5''—C6''—H6'' | 119.0 |
C35—C25—H25 | 107.3 | C1''—C6''—H6'' | 119.0 |
C27—C26—C25 | 113.19 (19) | C2'—N1—H1A | 108.9 |
C27—C26—H26A | 108.9 | C2'—N1—H1B | 109.3 |
C25—C26—H26A | 108.9 | H1A—N1—H1B | 109.5 |
C27—C26—H26B | 108.9 | C23—N2—C18 | 111.77 (19) |
C25—C26—H26B | 108.9 | C23—N2—C17 | 114.02 (19) |
H26A—C26—H26B | 107.8 | C18—N2—C17 | 116.80 (18) |
C26—C27—C28 | 109.07 (18) | C2''—N3—H3C | 108.5 |
C26—C27—H27A | 109.9 | C2''—N3—H3D | 109.0 |
C28—C27—H27A | 109.9 | H3C—N3—H3D | 109.5 |
C26—C27—H27B | 109.9 | C47—N4—C42 | 109.67 (17) |
C28—C27—H27B | 109.9 | C47—N4—C41 | 114.24 (17) |
H27A—C27—H27B | 108.3 | C42—N4—C41 | 117.19 (17) |
O9—C28—C27 | 109.62 (17) | C19—O2—C4 | 124.4 (2) |
O9—C28—C29 | 102.89 (16) | C9—O3—H3 | 109.5 |
C27—C28—C29 | 110.14 (18) | C8—O4—H4 | 109.5 |
O9—C28—C42 | 110.62 (17) | C22—O5—C14 | 113.9 (2) |
C27—C28—C42 | 114.03 (18) | C21—O6—C16 | 112.6 (2) |
C29—C28—C42 | 108.97 (17) | C20—O7—C1 | 114.2 (2) |
C28—C29—C30 | 108.75 (17) | C43—O9—C28 | 122.13 (17) |
C28—C29—C35 | 109.14 (17) | C25—O10—C44 | 113.1 (2) |
C30—C29—C35 | 104.76 (17) | C32—O11—H11 | 109.4 |
C28—C29—H29 | 111.3 | C45—O12—C38 | 112.77 (19) |
C30—C29—H29 | 111.3 | C46—O13—C40 | 112.65 (18) |
C35—C29—H29 | 111.3 | C33—O14—H14A | 109.3 |
O7—C1—C2—C3 | 161.3 (2) | O14—C33—C34—C35 | −89.7 (2) |
C11—C1—C2—C3 | 38.9 (3) | C38—C33—C34—C35 | 152.49 (18) |
C1—C2—C3—C4 | −51.2 (3) | C32—C33—C34—C35 | 35.2 (3) |
C2—C3—C4—O2 | 177.0 (2) | C28—C29—C35—C41 | −74.90 (19) |
C2—C3—C4—C5 | 65.4 (3) | C30—C29—C35—C41 | 41.42 (19) |
C2—C3—C4—C18 | −58.2 (3) | C28—C29—C35—C25 | 47.8 (2) |
O2—C4—C5—C6 | 65.3 (2) | C30—C29—C35—C25 | 164.15 (17) |
C3—C4—C5—C6 | −178.0 (2) | C28—C29—C35—C34 | 169.64 (16) |
C18—C4—C5—C6 | −51.3 (2) | C30—C29—C35—C34 | −74.0 (2) |
O2—C4—C5—C11 | 179.17 (18) | O10—C25—C35—C41 | −48.4 (2) |
C3—C4—C5—C11 | −64.2 (3) | C26—C25—C35—C41 | 74.9 (2) |
C18—C4—C5—C11 | 62.5 (2) | O10—C25—C35—C29 | −160.53 (17) |
C4—C5—C6—C7 | 101.3 (2) | C26—C25—C35—C29 | −37.2 (3) |
C11—C5—C6—C7 | −14.9 (2) | O10—C25—C35—C34 | 76.1 (2) |
C5—C6—C7—C8 | 102.43 (19) | C26—C25—C35—C34 | −160.53 (19) |
C5—C6—C7—C17 | −17.6 (2) | C33—C34—C35—C41 | −49.7 (2) |
C6—C7—C8—O4 | 64.9 (2) | C36—C34—C35—C41 | 73.5 (2) |
C17—C7—C8—O4 | 179.98 (18) | C33—C34—C35—C29 | 58.0 (2) |
C6—C7—C8—C15 | −177.73 (19) | C36—C34—C35—C29 | −178.83 (17) |
C17—C7—C8—C15 | −62.6 (2) | C33—C34—C35—C25 | −177.63 (18) |
C6—C7—C8—C9 | −51.6 (2) | C36—C34—C35—C25 | −54.4 (2) |
C17—C7—C8—C9 | 63.5 (2) | C33—C34—C36—C37 | 7.3 (2) |
O4—C8—C9—O3 | −31.9 (2) | C35—C34—C36—C37 | −123.20 (19) |
C7—C8—C9—O3 | 82.8 (2) | C34—C36—C37—C38 | −34.7 (2) |
C15—C8—C9—O3 | −151.70 (19) | C34—C36—C37—C40 | 84.5 (2) |
O4—C8—C9—C14 | 91.7 (2) | C40—C37—C38—O12 | 52.1 (3) |
C7—C8—C9—C14 | −153.64 (19) | C36—C37—C38—O12 | 169.60 (18) |
C15—C8—C9—C14 | −28.1 (3) | C40—C37—C38—C33 | −68.0 (2) |
O4—C8—C9—C10 | −155.01 (18) | C36—C37—C38—C33 | 49.5 (2) |
C7—C8—C9—C10 | −40.3 (3) | O14—C33—C38—O12 | 71.7 (2) |
C15—C8—C9—C10 | 85.2 (2) | C34—C33—C38—O12 | −172.71 (17) |
O3—C9—C10—C12 | 143.00 (19) | C32—C33—C38—O12 | −54.1 (2) |
C14—C9—C10—C12 | 25.9 (2) | O14—C33—C38—C37 | −161.82 (18) |
C8—C9—C10—C12 | −91.8 (2) | C34—C33—C38—C37 | −46.2 (2) |
O3—C9—C10—C11 | −88.4 (2) | C32—C33—C38—C37 | 72.4 (2) |
C14—C9—C10—C11 | 154.5 (2) | O11—C32—C39—C40 | −143.67 (19) |
C8—C9—C10—C11 | 36.9 (3) | C31—C32—C39—C40 | 101.0 (2) |
O7—C1—C11—C17 | −47.8 (3) | C33—C32—C39—C40 | −23.9 (3) |
C2—C1—C11—C17 | 74.3 (3) | C32—C39—C40—O13 | 150.93 (19) |
O7—C1—C11—C5 | −159.75 (19) | C32—C39—C40—C37 | 29.5 (3) |
C2—C1—C11—C5 | −37.6 (3) | C38—C37—C40—O13 | −105.1 (2) |
O7—C1—C11—C10 | 75.8 (2) | C36—C37—C40—O13 | 144.42 (19) |
C2—C1—C11—C10 | −162.1 (2) | C38—C37—C40—C39 | 17.8 (3) |
C4—C5—C11—C17 | −74.4 (2) | C36—C37—C40—C39 | −92.7 (2) |
C6—C5—C11—C17 | 41.2 (2) | C29—C35—C41—N4 | 69.81 (19) |
C4—C5—C11—C1 | 48.4 (2) | C25—C35—C41—N4 | −50.6 (2) |
C6—C5—C11—C1 | 164.07 (18) | C34—C35—C41—N4 | −174.11 (16) |
C4—C5—C11—C10 | 171.08 (18) | C29—C35—C41—C31 | −52.03 (17) |
C6—C5—C11—C10 | −73.3 (2) | C25—C35—C41—C31 | −172.41 (16) |
C9—C10—C11—C17 | −51.6 (3) | C34—C35—C41—C31 | 64.05 (19) |
C12—C10—C11—C17 | 70.7 (3) | C30—C31—C41—N4 | −73.1 (2) |
C9—C10—C11—C1 | −179.26 (19) | C32—C31—C41—N4 | 167.96 (17) |
C12—C10—C11—C1 | −57.0 (3) | C30—C31—C41—C35 | 43.99 (19) |
C9—C10—C11—C5 | 55.9 (3) | C32—C31—C41—C35 | −75.0 (2) |
C12—C10—C11—C5 | 178.2 (2) | O9—C28—C42—N4 | −153.09 (17) |
C9—C10—C12—C13 | 3.5 (2) | C27—C28—C42—N4 | 82.8 (2) |
C11—C10—C12—C13 | −126.2 (2) | C29—C28—C42—N4 | −40.7 (2) |
C10—C12—C13—C14 | −31.2 (3) | O1—C19—C1'—C6' | 179.2 (3) |
C10—C12—C13—C16 | 87.7 (3) | O2—C19—C1'—C6' | −0.1 (4) |
O3—C9—C14—O5 | 71.1 (2) | O1—C19—C1'—C2' | 3.2 (5) |
C10—C9—C14—O5 | −172.86 (18) | O2—C19—C1'—C2' | −176.2 (3) |
C8—C9—C14—O5 | −53.9 (3) | C6'—C1'—C2'—N1 | 179.3 (3) |
O3—C9—C14—C13 | −163.2 (2) | C19—C1'—C2'—N1 | −4.6 (5) |
C10—C9—C14—C13 | −47.2 (2) | C6'—C1'—C2'—C3' | −1.6 (4) |
C8—C9—C14—C13 | 71.8 (2) | C19—C1'—C2'—C3' | 174.5 (3) |
C16—C13—C14—O5 | 49.6 (3) | N1—C2'—C3'—C4' | −179.0 (4) |
C12—C13—C14—O5 | 167.5 (2) | C1'—C2'—C3'—C4' | 1.9 (5) |
C16—C13—C14—C9 | −69.9 (3) | C2'—C3'—C4'—C5' | −0.3 (7) |
C12—C13—C14—C9 | 48.1 (2) | C3'—C4'—C5'—C6' | −1.4 (8) |
O4—C8—C15—C16 | −140.2 (2) | C4'—C5'—C6'—C1' | 1.6 (8) |
C7—C8—C15—C16 | 104.0 (2) | C2'—C1'—C6'—C5' | −0.1 (6) |
C9—C8—C15—C16 | −20.4 (3) | C19—C1'—C6'—C5' | −176.3 (4) |
C8—C15—C16—O6 | 144.3 (2) | O8—C43—C1''—C6'' | 174.7 (2) |
C8—C15—C16—C13 | 23.5 (3) | O9—C43—C1''—C6'' | −4.4 (3) |
C14—C13—C16—O6 | −100.5 (3) | O8—C43—C1''—C2'' | −3.5 (4) |
C12—C13—C16—O6 | 148.5 (2) | O9—C43—C1''—C2'' | 177.4 (2) |
C14—C13—C16—C15 | 22.4 (3) | C6''—C1''—C2''—N3 | 178.6 (3) |
C12—C13—C16—C15 | −88.6 (3) | C43—C1''—C2''—N3 | −3.1 (4) |
C1—C11—C17—N2 | −50.0 (3) | C6''—C1''—C2''—C3'' | 0.6 (4) |
C5—C11—C17—N2 | 70.1 (2) | C43—C1''—C2''—C3'' | 178.9 (3) |
C10—C11—C17—N2 | −173.27 (17) | N3—C2''—C3''—C4'' | −179.6 (3) |
C1—C11—C17—C7 | −171.74 (19) | C1''—C2''—C3''—C4'' | −1.6 (5) |
C5—C11—C17—C7 | −51.62 (19) | C2''—C3''—C4''—C5'' | 1.8 (5) |
C10—C11—C17—C7 | 65.0 (2) | C3''—C4''—C5''—C6'' | −1.1 (5) |
C8—C7—C17—N2 | 167.96 (18) | C4''—C5''—C6''—C1'' | 0.2 (4) |
C6—C7—C17—N2 | −72.8 (2) | C2''—C1''—C6''—C5'' | 0.0 (4) |
C8—C7—C17—C11 | −75.3 (2) | C43—C1''—C6''—C5'' | −178.3 (2) |
C6—C7—C17—C11 | 44.0 (2) | C24—C23—N2—C18 | 157.0 (2) |
O2—C4—C18—N2 | −153.59 (18) | C24—C23—N2—C17 | −67.8 (3) |
C3—C4—C18—N2 | 82.0 (3) | C4—C18—N2—C23 | 176.49 (19) |
C5—C4—C18—N2 | −42.6 (3) | C4—C18—N2—C17 | 42.6 (3) |
O10—C25—C26—C27 | 164.22 (19) | C11—C17—N2—C23 | 168.01 (19) |
C35—C25—C26—C27 | 40.0 (3) | C7—C17—N2—C23 | −79.8 (3) |
C25—C26—C27—C28 | −53.2 (3) | C11—C17—N2—C18 | −59.1 (2) |
C26—C27—C28—O9 | 179.43 (18) | C7—C17—N2—C18 | 53.0 (3) |
C26—C27—C28—C29 | 66.9 (2) | C48—C47—N4—C42 | 165.8 (2) |
C26—C27—C28—C42 | −55.9 (3) | C48—C47—N4—C41 | −60.4 (3) |
O9—C28—C29—C30 | 65.5 (2) | C28—C42—N4—C47 | 172.51 (19) |
C27—C28—C29—C30 | −177.69 (18) | C28—C42—N4—C41 | 40.2 (2) |
C42—C28—C29—C30 | −51.9 (2) | C35—C41—N4—C47 | 172.30 (19) |
O9—C28—C29—C35 | 179.26 (16) | C31—C41—N4—C47 | −75.2 (2) |
C27—C28—C29—C35 | −63.9 (2) | C35—C41—N4—C42 | −57.4 (2) |
C42—C28—C29—C35 | 61.8 (2) | C31—C41—N4—C42 | 55.0 (2) |
C28—C29—C30—C31 | 101.63 (19) | O1—C19—O2—C4 | −7.9 (4) |
C35—C29—C30—C31 | −15.0 (2) | C1'—C19—O2—C4 | 171.5 (2) |
C29—C30—C31—C32 | 101.46 (19) | C3—C4—O2—C19 | 73.0 (3) |
C29—C30—C31—C41 | −17.4 (2) | C5—C4—O2—C19 | −169.6 (2) |
C30—C31—C32—O11 | 67.1 (2) | C18—C4—O2—C19 | −54.0 (3) |
C41—C31—C32—O11 | −179.00 (17) | C9—C14—O5—C22 | −160.9 (3) |
C30—C31—C32—C39 | −175.93 (17) | C13—C14—O5—C22 | 82.7 (3) |
C41—C31—C32—C39 | −62.0 (2) | C15—C16—O6—C21 | 68.2 (4) |
C30—C31—C32—C33 | −49.7 (2) | C13—C16—O6—C21 | −167.3 (3) |
C41—C31—C32—C33 | 64.3 (2) | C2—C1—O7—C20 | 81.8 (3) |
O11—C32—C33—O14 | −33.1 (2) | C11—C1—O7—C20 | −150.6 (3) |
C31—C32—C33—O14 | 81.5 (2) | O8—C43—O9—C28 | 3.2 (3) |
C39—C32—C33—O14 | −152.54 (18) | C1''—C43—O9—C28 | −177.64 (18) |
O11—C32—C33—C38 | 91.7 (2) | C27—C28—O9—C43 | 70.0 (2) |
C31—C32—C33—C38 | −153.70 (18) | C29—C28—O9—C43 | −172.83 (18) |
C39—C32—C33—C38 | −27.8 (2) | C42—C28—O9—C43 | −56.6 (2) |
O11—C32—C33—C34 | −155.17 (17) | C26—C25—O10—C44 | 79.8 (2) |
C31—C32—C33—C34 | −40.6 (2) | C35—C25—O10—C44 | −151.8 (2) |
C39—C32—C33—C34 | 85.4 (2) | C37—C38—O12—C45 | 64.2 (3) |
O14—C33—C34—C36 | 140.79 (18) | C33—C38—O12—C45 | −179.2 (2) |
C38—C33—C34—C36 | 22.9 (2) | C39—C40—O13—C46 | 75.9 (3) |
C32—C33—C34—C36 | −94.3 (2) | C37—C40—O13—C46 | −159.8 (2) |
D—H···A | D—H | H···A | D···A | D—H···A |
O14—H14A···O6i | 0.98 | 2.27 | 2.927 (2) | 123 |
O11—H11···O12 | 0.84 | 2.40 | 2.944 (2) | 124 |
O4—H4···O5 | 0.84 | 2.33 | 2.914 (3) | 127 |
O3—H3···O13ii | 0.84 | 2.41 | 3.095 (2) | 139 |
N3—H3D···O8 | 0.91 | 2.02 | 2.687 (3) | 129 |
N1—H1A···O1 | 0.91 | 2.02 | 2.752 (4) | 137 |
Symmetry codes: (i) −x+1/2, −y+1, z+1/2; (ii) −x+1/2, −y, z−1/2. |
D—H···A | D—H | H···A | D···A | D—H···A |
O14—H14A···O6i | 0.98 | 2.27 | 2.927 (2) | 123.2 |
O11—H11···O12 | 0.84 | 2.40 | 2.944 (2) | 123.5 |
O4—H4···O5 | 0.84 | 2.33 | 2.914 (3) | 126.8 |
O3—H3···O13ii | 0.84 | 2.41 | 3.095 (2) | 138.8 |
N3—H3D···O8 | 0.91 | 2.02 | 2.687 (3) | 129.3 |
N1—H1A···O1 | 0.91 | 2.02 | 2.752 (4) | 136.7 |
Symmetry codes: (i) −x+1/2, −y+1, z+1/2; (ii) −x+1/2, −y, z−1/2. |
Acknowledgements
This project was supported by the Science and Technology Research and Development Projects of Shaanxi Province (grant No. 2013KJXX-74), the National Natural Science Foundation of China (grant No. 31200257) and the West Light Foundation of The Chinese Academy of Sciences (grant No. 2012DF05).
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