organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

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ISSN: 2056-9890

Crystal structure of N-de­acetyl­lappa­coni­tine

aXi'an Botanical Garden, Institute of Botany of Shaanxi Province, Xi'an 710061, People's Republic of China
*Correspondence e-mail: sxw@ms.xab.ac.cn

Edited by V. V. Chernyshev, Moscow State University, Russia (Received 14 June 2015; accepted 26 June 2015; online 15 July 2015)

The title compound, C30H42N2O7 [systematic name: (1S,4S,5S,7S,8S,9S,10S,11S,13R,14S,16S,17R)-20-ethyl-4,8,9-trihy­droxy-1,14,16-tri­meth­oxy­aconitan-4-yl 2-amino­benzoate], isolated from roots of Aconitum sinomontanum Nakai, is a typical aconitane-type C19-diterpenoid alkaloid, which crystallizes with two independent mol­ecules in the asymmetric unit. The conformations of the two independent mol­ecules are closely similar. Each mol­ecule comprises four six-membered rings (A, B, D and E) including one six-membered N-containing heterocyclic ring (E), and two five-membered rings (C and F). Rings A, B and E adopt chair conformations, while ring D displays a boat conformation. Five-membered rings C and F exhibit envelope conformations. IntramolecularN—H⋯O hydrogen bonds between the amino group and carbonyl O atom help to stabilize molecular structure. In the crystal, O—H⋯O hydrogen bonds link the mol­ecules into zigzag chains propagating in [010].

1. Related literature

For reviews of typical C19-diterpenoid alkaloids, see: Wang et al. (2009[Wang, F.-P., Chen, Q.-H. & Liang, X.-T. (2009). The Alkaloids: Chemistry and Biology, Vol. 67, edited by G. A. Cordell, pp. 1-78. New York: Elsevier.], 2010[Wang, F.-P., Chen, Q.-H. & Liu, X.-Y. (2010). Nat. Prod. Rep. 27, 529-570.]). For the isolation, idenfication and biological activity of N-de­acetyl­lappaconitine, see: Peng et al. (2000[Peng, C.-S., Wang, J.-Z., Jian, X.-X. & Wang, F.-F. (2000). Tianran Chanwu Yanjiu Yu Kaifa. 12, 45-51.]); Romanov et al. (2008[Romanov, V. E., Shul'ts, E. E., Shakirov, M. M. & Tolstikov, G. A. (2008). Chem. Nat. Compd. 44, 346-351.]). For ring numbering, ring conformations and absolute configurations of C19-diterpenoid alkaloids, see: Wang et al. (2007[Wang, Y.-P., Sun, W.-X., Zhang, J., Liu, H.-S. & Wen, H.-H. (2007). Acta Cryst. E63, o1645-o1647.]); He et al. (2008[He, D.-H., Zhu, Y.-C. & Hu, A.-X. (2008). Acta Cryst. E64, o1033-o1034.]).

[Scheme 1]

2. Experimental

2.1. Crystal data

  • C30H42N2O7

  • Mr = 542.66

  • Orthorhombic, P 21 21 21

  • a = 11.7090 (3) Å

  • b = 13.2040 (4) Å

  • c = 35.7380 (9) Å

  • V = 5525.3 (3) Å3

  • Z = 8

  • Cu Kα radiation

  • μ = 0.75 mm−1

  • T = 173 K

  • 0.30 × 0.30 × 0.30 mm

2.2. Data collection

  • Bruker SMART CCD area-detector diffractometer

  • Absorption correction: multi-scan (SADABS; Bruker, 2002[Bruker (2002). SADABS, SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.]) Tmin = 0.806, Tmax = 0.806

  • 18595 measured reflections

  • 8477 independent reflections

  • 7744 reflections with I > 2σ(I)

  • Rint = 0.030

2.3. Refinement

  • R[F2 > 2σ(F2)] = 0.042

  • wR(F2) = 0.111

  • S = 1.02

  • 8477 reflections

  • 713 parameters

  • H-atom parameters constrained

  • Δρmax = 0.26 e Å−3

  • Δρmin = −0.19 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A DA D—H⋯A
O14—H14A⋯O6i 0.98 2.27 2.927 (2) 123
O11—H11⋯O12 0.84 2.40 2.944 (2) 124
O4—H4⋯O5 0.84 2.33 2.914 (3) 127
O3—H3⋯O13ii 0.84 2.41 3.095 (2) 139
N3—H3D⋯O8 0.91 2.02 2.687 (3) 129
N1—H1A⋯O1 0.91 2.02 2.752 (4) 137
Symmetry codes: (i) [-x+{\script{1\over 2}}, -y+1, z+{\script{1\over 2}}]; (ii) [-x+{\script{1\over 2}}, -y, z-{\script{1\over 2}}].

Data collection: SMART (Bruker, 2002[Bruker (2002). SADABS, SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.]); cell refinement: SAINT; data reduction: SAINT (Bruker, 2002[Bruker (2002). SADABS, SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.]); program(s) used to solve structure: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL and Mercury (Macrae et al., 2008[Macrae, C. F., Bruno, I. J., Chisholm, J. A., Edgington, P. R., McCabe, P., Pidcock, E., Rodriguez-Monge, L., Taylor, R., van de Streek, J. & Wood, P. A. (2008). J. Appl. Cryst. 41, 466-470.]); software used to prepare material for publication: SHELXTL.

Supporting information


Comment top

The title compound, N-de­acetyl­lappaconitine, is produced by several species of the plant genus Aconitum (A. sinomontanum, A. barbatum, A. septentrionale, A. leucostomum, A. orientale) and its structure was confirmed by the NMR and MS data. It possesses anti­arrhythmic, analgesic, local anesthetic, sedative and anti-inflammatory activity (Peng et al. 2000; Wang et al. 2009, 2010; Romanov et al. 2008). Herewith we present the crystal structure of N-de­acetyl­lappaconitine (I).

The title compound (I) crystallizes with two independent molecules in the asymmetric unit (Fig. 1). The confomations of both molecules are close (Fig. 2) due to intra­molecular N—H···O and O—H···O hydrogen bonds (Table 1). Each molecule is composed from six rings labelled as A-F (Wang et al., 2007). Six-membered rings A (C1–C5/C11) and B (C7–C11/C17) adopt chair conformations; six-membered N-containing heterocyclic ring E (C4/C5/C11/C17/N2/C18) display the same chair conformation; the five-membered rings C (C9/C10/C12/C13/C14) and F (C5/C6/C7/C17/C11) form envelope conformations, in which, atoms C13 and C17, respectively, play the role of flap. The six-membered ring D (C8/C9/C14/C13/C16/C15) is in a boat conformation.

In the crystal, inter­molecular O—H···O hydrogen bonds (Table 1) link the molecules into zigzag chains propagated in [010] .

Experimental top

The title compound was isolated from the roots of Aconitum sinomontanum Nakai following the known procedure (Peng et al., 2000). Colourless single crystals suitable for X-ray diffraction were obtained by slow evaporation from a methanol solution for two weeks at the room temperacture.

Refinement top

The hydrogen atoms were placed in calculated positions and refined as riding with Uiso(H) =1.2–1.5 Ueq (C, O). The positions of methyl and hy­droxy hydrogens were rotationally optimized. In spite of acceptable value of Flack parameter of -0.07 (15) in the abscence of anomalous scatterers, the absolute configuration of the title compound has been assigned to be the same as that reported for typical natural aconitane-type C19-diterpenoid alkaloids (Wang et al., 2007; He et al., 2008).

Related literature top

For reviews of typical C19-diterpenoid alkaloids, see: Wang et al. (2009, 2010). For the isolation, idenfication and biological activity of N-deacetyllappaconitine, see: Peng et al. (2000); Romanov et al. (2008). For ring numbering, ring conformations and absolute configurations of C19-diterpenoid alkaloids, see: Wang et al. (2007); He et al. (2008).

Structure description top

The title compound, N-de­acetyl­lappaconitine, is produced by several species of the plant genus Aconitum (A. sinomontanum, A. barbatum, A. septentrionale, A. leucostomum, A. orientale) and its structure was confirmed by the NMR and MS data. It possesses anti­arrhythmic, analgesic, local anesthetic, sedative and anti-inflammatory activity (Peng et al. 2000; Wang et al. 2009, 2010; Romanov et al. 2008). Herewith we present the crystal structure of N-de­acetyl­lappaconitine (I).

The title compound (I) crystallizes with two independent molecules in the asymmetric unit (Fig. 1). The confomations of both molecules are close (Fig. 2) due to intra­molecular N—H···O and O—H···O hydrogen bonds (Table 1). Each molecule is composed from six rings labelled as A-F (Wang et al., 2007). Six-membered rings A (C1–C5/C11) and B (C7–C11/C17) adopt chair conformations; six-membered N-containing heterocyclic ring E (C4/C5/C11/C17/N2/C18) display the same chair conformation; the five-membered rings C (C9/C10/C12/C13/C14) and F (C5/C6/C7/C17/C11) form envelope conformations, in which, atoms C13 and C17, respectively, play the role of flap. The six-membered ring D (C8/C9/C14/C13/C16/C15) is in a boat conformation.

In the crystal, inter­molecular O—H···O hydrogen bonds (Table 1) link the molecules into zigzag chains propagated in [010] .

The title compound was isolated from the roots of Aconitum sinomontanum Nakai following the known procedure (Peng et al., 2000). Colourless single crystals suitable for X-ray diffraction were obtained by slow evaporation from a methanol solution for two weeks at the room temperacture.

For reviews of typical C19-diterpenoid alkaloids, see: Wang et al. (2009, 2010). For the isolation, idenfication and biological activity of N-deacetyllappaconitine, see: Peng et al. (2000); Romanov et al. (2008). For ring numbering, ring conformations and absolute configurations of C19-diterpenoid alkaloids, see: Wang et al. (2007); He et al. (2008).

Refinement details top

The hydrogen atoms were placed in calculated positions and refined as riding with Uiso(H) =1.2–1.5 Ueq (C, O). The positions of methyl and hy­droxy hydrogens were rotationally optimized. In spite of acceptable value of Flack parameter of -0.07 (15) in the abscence of anomalous scatterers, the absolute configuration of the title compound has been assigned to be the same as that reported for typical natural aconitane-type C19-diterpenoid alkaloids (Wang et al., 2007; He et al., 2008).

Computing details top

Data collection: SMART (Bruker, 2002); cell refinement: SAINT (Bruker, 2002); data reduction: SAINT (Bruker, 2002); program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008) and Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. Two independent molecules in the asymmetric unit showing the atomic labeling and 30% probabilty displacement ellipsoids. H atoms omitted for clarity.
[Figure 2] Fig. 2. The overlay of two independent molecules.
(I) top
Crystal data top
C30H42N2O7F(000) = 2336
Mr = 542.66Dx = 1.305 Mg m3
Orthorhombic, P212121Cu Kα radiation, λ = 1.54184 Å
Hall symbol: P 2ac 2abCell parameters from 7732 reflections
a = 11.7090 (3) Åθ = 3.6–66.9°
b = 13.2040 (4) ŵ = 0.75 mm1
c = 35.7380 (9) ÅT = 173 K
V = 5525.3 (3) Å3Prism, colourless
Z = 80.30 × 0.30 × 0.30 mm
Data collection top
Bruker SMART CCD area-detector
diffractometer
8477 independent reflections
Radiation source: fine-focus sealed tube7744 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.030
phi and ω scansθmax = 65.0°, θmin = 2.5°
Absorption correction: multi-scan
(SADABS; Bruker, 2002)
h = 1313
Tmin = 0.806, Tmax = 0.806k = 1215
18595 measured reflectionsl = 4238
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.042Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.111H-atom parameters constrained
S = 1.02 w = 1/[σ2(Fo2) + (0.0677P)2 + 0.5213P]
where P = (Fo2 + 2Fc2)/3
8477 reflections(Δ/σ)max = 0.001
713 parametersΔρmax = 0.26 e Å3
0 restraintsΔρmin = 0.19 e Å3
Crystal data top
C30H42N2O7V = 5525.3 (3) Å3
Mr = 542.66Z = 8
Orthorhombic, P212121Cu Kα radiation
a = 11.7090 (3) ŵ = 0.75 mm1
b = 13.2040 (4) ÅT = 173 K
c = 35.7380 (9) Å0.30 × 0.30 × 0.30 mm
Data collection top
Bruker SMART CCD area-detector
diffractometer
8477 independent reflections
Absorption correction: multi-scan
(SADABS; Bruker, 2002)
7744 reflections with I > 2σ(I)
Tmin = 0.806, Tmax = 0.806Rint = 0.030
18595 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0420 restraints
wR(F2) = 0.111H-atom parameters constrained
S = 1.02Δρmax = 0.26 e Å3
8477 reflectionsΔρmin = 0.19 e Å3
713 parameters
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
C10.2568 (2)0.43649 (19)0.54143 (6)0.0422 (6)
H10.34040.43300.53580.051*
C20.2385 (2)0.3917 (2)0.58046 (6)0.0505 (6)
H2A0.30220.41320.59680.061*
H2B0.16710.41980.59110.061*
C30.2312 (2)0.2773 (2)0.58093 (7)0.0527 (7)
H3A0.30690.24790.57510.063*
H3B0.20810.25380.60610.063*
C40.1451 (2)0.24306 (19)0.55241 (6)0.0401 (5)
C50.1853 (2)0.26898 (18)0.51258 (6)0.0359 (5)
H50.26020.23620.50670.043*
C60.0911 (2)0.23517 (18)0.48488 (6)0.0388 (5)
H6A0.12500.20380.46230.047*
H6B0.03870.18600.49680.047*
C70.02808 (19)0.33336 (18)0.47485 (6)0.0364 (5)
H70.05640.32210.47540.044*
C80.06474 (19)0.37144 (19)0.43617 (6)0.0380 (5)
C90.19841 (18)0.37717 (18)0.43412 (6)0.0362 (5)
C100.25048 (19)0.41825 (18)0.47103 (6)0.0369 (5)
H100.33080.39270.47210.044*
C110.19213 (18)0.38589 (18)0.50856 (6)0.0342 (5)
C120.2580 (3)0.5349 (2)0.46378 (7)0.0541 (7)
H12A0.21600.57250.48340.065*
H12B0.33870.55740.46400.065*
C130.2039 (2)0.5545 (2)0.42508 (7)0.0503 (6)
H130.24130.61330.41240.060*
C140.2339 (2)0.4561 (2)0.40577 (6)0.0454 (6)
H140.31850.45270.40220.054*
C150.0062 (2)0.4726 (2)0.42595 (7)0.0480 (6)
H15A0.02280.46640.40000.058*
H15B0.06120.48030.44240.058*
C160.0749 (3)0.5707 (2)0.42826 (7)0.0531 (7)
H160.05860.60350.45290.064*
C170.06348 (18)0.40758 (17)0.50614 (6)0.0336 (5)
H170.04970.47920.49820.040*
C180.0243 (2)0.28618 (19)0.55827 (7)0.0415 (5)
H18A0.03190.24100.54600.050*
H18B0.00700.28750.58540.050*
C190.0950 (2)0.0736 (2)0.57788 (7)0.0531 (7)
C200.3107 (4)0.6053 (3)0.55720 (12)0.0920 (12)
H20A0.32410.58910.58360.138*
H20B0.28590.67600.55500.138*
H20C0.38140.59560.54300.138*
C210.0699 (4)0.6774 (3)0.40392 (12)0.1110 (17)
H21A0.12430.62100.40370.167*
H21B0.08780.72410.38340.167*
H21C0.07510.71330.42780.167*
C220.2309 (3)0.4802 (3)0.34001 (8)0.0855 (11)
H22A0.22150.55380.34170.128*
H22B0.19490.45560.31700.128*
H22C0.31240.46350.33960.128*
C230.1048 (2)0.4258 (2)0.54681 (7)0.0426 (5)
H23A0.13740.40020.57060.051*
H23B0.15140.39810.52610.051*
C240.1135 (3)0.5397 (2)0.54635 (9)0.0624 (8)
H24A0.05920.56820.56440.094*
H24B0.19120.56000.55320.094*
H24C0.09570.56480.52120.094*
C250.39217 (18)0.08850 (16)0.71788 (6)0.0320 (5)
H250.47670.09420.72120.038*
C260.3616 (2)0.14105 (18)0.68090 (6)0.0408 (5)
H26A0.42000.12370.66190.049*
H26B0.28730.11480.67200.049*
C270.3544 (2)0.25473 (18)0.68429 (6)0.0399 (5)
H27A0.32610.28410.66050.048*
H27B0.43110.28310.68940.048*
C280.27342 (18)0.28149 (16)0.71598 (6)0.0313 (5)
C290.32419 (18)0.24848 (16)0.75345 (6)0.0309 (4)
H290.39940.28200.75820.037*
C300.2373 (2)0.27287 (16)0.78494 (6)0.0364 (5)
H30A0.27680.30060.80720.044*
H30B0.18020.32280.77620.044*
C310.18008 (18)0.17164 (16)0.79424 (6)0.0334 (5)
H310.09560.18040.79670.040*
C320.22999 (19)0.12554 (17)0.83008 (6)0.0350 (5)
C330.36444 (19)0.12486 (17)0.82810 (6)0.0338 (5)
C340.40731 (17)0.09500 (16)0.78846 (6)0.0312 (4)
H340.48460.12630.78560.037*
C350.33562 (16)0.13118 (15)0.75396 (5)0.0272 (4)
C360.42728 (19)0.02177 (18)0.79183 (6)0.0383 (5)
H36A0.38650.05800.77160.046*
H36B0.50970.03760.79000.046*
C370.38056 (19)0.05397 (17)0.83042 (6)0.0361 (5)
H370.42220.11470.84010.043*
C380.41089 (19)0.03980 (18)0.85266 (6)0.0369 (5)
H380.49590.04580.85390.044*
C390.17956 (19)0.01971 (18)0.83848 (6)0.0391 (5)
H39A0.16240.01660.86560.047*
H39B0.10590.01420.82500.047*
C400.2514 (2)0.07378 (17)0.82849 (6)0.0366 (5)
H400.23190.09470.80240.044*
C410.20902 (16)0.10515 (16)0.75957 (6)0.0284 (4)
H410.19990.03170.76570.034*
C420.15309 (19)0.23520 (17)0.71190 (6)0.0367 (5)
H42A0.09810.27700.72620.044*
H42B0.13040.23740.68520.044*
C430.21456 (19)0.45045 (17)0.69410 (6)0.0368 (5)
C440.4515 (3)0.0713 (2)0.69438 (9)0.0706 (9)
H44A0.46050.04280.66920.106*
H44B0.42860.14250.69240.106*
H44C0.52420.06670.70790.106*
C450.4057 (3)0.0248 (2)0.91444 (7)0.0575 (7)
H45A0.36670.08900.90920.086*
H45B0.39010.00410.94030.086*
H45C0.48820.03370.91100.086*
C460.1203 (2)0.2031 (2)0.84451 (8)0.0578 (7)
H46A0.05780.15530.84900.087*
H46B0.11020.26300.86040.087*
H46C0.12000.22360.81820.087*
C470.02761 (19)0.09681 (19)0.72501 (7)0.0428 (6)
H47A0.00840.11890.70130.051*
H47B0.01320.13070.74580.051*
C480.0124 (2)0.0161 (2)0.72891 (10)0.0645 (8)
H48A0.06170.05090.71090.097*
H48B0.06750.03390.72410.097*
H48C0.03320.03680.75430.097*
C1'0.0897 (2)0.0336 (2)0.56605 (8)0.0553 (7)
C2'0.0381 (2)0.1087 (3)0.58835 (9)0.0642 (8)
C3'0.0275 (3)0.2063 (3)0.57384 (13)0.0817 (11)
H3'0.00920.25710.58830.098*
C4'0.0689 (4)0.2303 (3)0.53928 (13)0.0997 (14)
H4'0.06120.29740.53000.120*
C5'0.1214 (5)0.1580 (3)0.51803 (12)0.1061 (15)
H5'0.15170.17520.49420.127*
C6'0.1303 (4)0.0612 (3)0.53097 (9)0.0766 (10)
H6'0.16530.01140.51560.092*
C1''0.22222 (19)0.55868 (17)0.70302 (6)0.0365 (5)
C2''0.1771 (3)0.6321 (2)0.67866 (8)0.0542 (7)
C3''0.1854 (3)0.7340 (2)0.68911 (10)0.0672 (9)
H3''0.15710.78460.67270.081*
C4''0.2335 (3)0.7625 (2)0.72248 (10)0.0643 (8)
H4''0.23610.83210.72920.077*
C5''0.2778 (2)0.6908 (2)0.74615 (8)0.0548 (7)
H5''0.31220.71060.76910.066*
C6''0.2721 (2)0.59137 (19)0.73669 (7)0.0429 (5)
H6''0.30290.54240.75330.051*
N10.0034 (3)0.0889 (3)0.62340 (8)0.0928 (10)
H1A0.02420.02810.63120.111*
H1B0.02010.13840.63940.111*
N20.01194 (16)0.38839 (15)0.54309 (5)0.0373 (4)
N30.1290 (3)0.6066 (2)0.64485 (7)0.0889 (10)
H3C0.07350.65260.63940.107*
H3D0.09740.54380.64670.107*
N40.14633 (14)0.13030 (14)0.72516 (5)0.0328 (4)
O10.0612 (2)0.10686 (18)0.60764 (5)0.0740 (6)
O20.14170 (17)0.13201 (13)0.55120 (4)0.0500 (4)
O30.24945 (15)0.28229 (13)0.42563 (4)0.0443 (4)
H30.22000.25860.40610.066*
O40.02651 (16)0.29539 (14)0.41009 (5)0.0487 (4)
H40.04380.31300.38820.073*
O50.17912 (16)0.43398 (15)0.37103 (4)0.0538 (5)
O60.0426 (2)0.63931 (16)0.39921 (6)0.0710 (6)
O70.22516 (17)0.54113 (14)0.54284 (5)0.0554 (5)
O80.16607 (18)0.41487 (13)0.66696 (5)0.0538 (5)
O90.26648 (14)0.39190 (11)0.71983 (4)0.0373 (3)
O100.36612 (14)0.01612 (12)0.71417 (4)0.0407 (4)
O110.19519 (16)0.19342 (13)0.85988 (4)0.0490 (4)
H110.21130.16730.88060.059*
O120.36556 (16)0.05052 (14)0.88956 (4)0.0481 (4)
O130.22545 (14)0.15629 (13)0.85308 (4)0.0448 (4)
O140.41392 (15)0.21944 (12)0.83770 (4)0.0441 (4)
H14A0.37530.24670.85990.053*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
C10.0410 (12)0.0460 (14)0.0396 (12)0.0053 (11)0.0029 (10)0.0089 (11)
C20.0540 (14)0.0645 (18)0.0329 (12)0.0067 (14)0.0057 (11)0.0124 (12)
C30.0592 (15)0.0672 (19)0.0317 (12)0.0090 (14)0.0042 (11)0.0023 (12)
C40.0501 (13)0.0397 (14)0.0304 (11)0.0055 (11)0.0030 (10)0.0013 (10)
C50.0430 (11)0.0346 (13)0.0300 (10)0.0044 (10)0.0022 (9)0.0028 (9)
C60.0528 (13)0.0309 (12)0.0328 (11)0.0056 (11)0.0021 (10)0.0010 (9)
C70.0375 (11)0.0377 (13)0.0339 (11)0.0049 (10)0.0020 (9)0.0020 (10)
C80.0419 (12)0.0401 (14)0.0319 (11)0.0001 (10)0.0036 (9)0.0001 (10)
C90.0404 (11)0.0365 (13)0.0318 (11)0.0025 (10)0.0049 (9)0.0010 (9)
C100.0363 (11)0.0398 (13)0.0346 (11)0.0016 (10)0.0037 (9)0.0031 (10)
C110.0359 (10)0.0376 (13)0.0290 (10)0.0020 (10)0.0004 (9)0.0028 (9)
C120.0649 (16)0.0497 (16)0.0476 (14)0.0161 (14)0.0096 (13)0.0014 (13)
C130.0678 (16)0.0390 (14)0.0440 (13)0.0073 (13)0.0152 (12)0.0097 (11)
C140.0482 (12)0.0507 (15)0.0373 (12)0.0017 (12)0.0070 (10)0.0046 (11)
C150.0514 (13)0.0521 (16)0.0403 (13)0.0120 (12)0.0034 (11)0.0064 (12)
C160.0776 (18)0.0401 (14)0.0415 (13)0.0126 (14)0.0174 (13)0.0076 (11)
C170.0403 (11)0.0304 (12)0.0302 (10)0.0013 (9)0.0027 (9)0.0005 (9)
C180.0490 (13)0.0394 (14)0.0359 (12)0.0039 (11)0.0088 (10)0.0037 (10)
C190.0596 (15)0.0547 (17)0.0449 (14)0.0114 (14)0.0035 (12)0.0175 (13)
C200.107 (3)0.060 (2)0.109 (3)0.020 (2)0.031 (2)0.026 (2)
C210.126 (3)0.095 (3)0.112 (3)0.070 (3)0.051 (3)0.049 (3)
C220.096 (2)0.120 (3)0.0402 (15)0.004 (2)0.0096 (16)0.0289 (18)
C230.0408 (11)0.0427 (14)0.0443 (12)0.0018 (11)0.0094 (10)0.0046 (11)
C240.0607 (16)0.0464 (17)0.080 (2)0.0064 (14)0.0222 (15)0.0036 (15)
C250.0344 (10)0.0266 (11)0.0352 (11)0.0008 (9)0.0069 (9)0.0022 (9)
C260.0531 (13)0.0394 (13)0.0300 (11)0.0009 (11)0.0092 (10)0.0009 (10)
C270.0517 (13)0.0338 (13)0.0341 (11)0.0029 (11)0.0052 (10)0.0083 (10)
C280.0401 (11)0.0230 (11)0.0309 (10)0.0018 (9)0.0039 (9)0.0014 (8)
C290.0367 (10)0.0242 (11)0.0317 (10)0.0015 (9)0.0028 (9)0.0022 (9)
C300.0543 (13)0.0243 (11)0.0308 (10)0.0111 (10)0.0008 (10)0.0002 (9)
C310.0354 (10)0.0297 (12)0.0351 (11)0.0092 (9)0.0042 (9)0.0005 (9)
C320.0416 (11)0.0325 (12)0.0309 (10)0.0075 (10)0.0079 (9)0.0010 (9)
C330.0409 (11)0.0282 (12)0.0324 (11)0.0012 (10)0.0019 (9)0.0016 (9)
C340.0307 (9)0.0291 (12)0.0338 (11)0.0006 (9)0.0024 (8)0.0009 (9)
C350.0304 (9)0.0233 (11)0.0278 (10)0.0007 (8)0.0010 (8)0.0006 (8)
C360.0427 (11)0.0337 (12)0.0386 (12)0.0092 (10)0.0065 (10)0.0072 (10)
C370.0418 (12)0.0299 (12)0.0367 (11)0.0070 (10)0.0006 (9)0.0087 (9)
C380.0355 (10)0.0406 (13)0.0347 (11)0.0011 (10)0.0011 (9)0.0046 (10)
C390.0363 (10)0.0428 (14)0.0382 (12)0.0029 (10)0.0061 (9)0.0104 (10)
C400.0452 (12)0.0309 (12)0.0337 (11)0.0005 (10)0.0017 (9)0.0065 (9)
C410.0306 (10)0.0224 (10)0.0323 (10)0.0010 (8)0.0027 (8)0.0026 (8)
C420.0416 (11)0.0313 (12)0.0372 (11)0.0007 (10)0.0066 (9)0.0037 (10)
C430.0458 (12)0.0311 (12)0.0335 (11)0.0012 (10)0.0023 (9)0.0058 (9)
C440.098 (2)0.0424 (16)0.0711 (19)0.0198 (17)0.0277 (18)0.0096 (14)
C450.0682 (16)0.0618 (18)0.0424 (13)0.0017 (15)0.0074 (12)0.0179 (13)
C460.0608 (16)0.0573 (18)0.0553 (15)0.0205 (15)0.0011 (13)0.0116 (13)
C470.0357 (11)0.0384 (14)0.0543 (14)0.0030 (10)0.0076 (10)0.0064 (11)
C480.0518 (15)0.0461 (17)0.095 (2)0.0143 (13)0.0165 (15)0.0080 (16)
C1'0.0630 (15)0.0443 (16)0.0587 (16)0.0072 (14)0.0055 (13)0.0178 (13)
C2'0.0569 (15)0.064 (2)0.0711 (19)0.0147 (16)0.0082 (14)0.0300 (16)
C3'0.078 (2)0.049 (2)0.118 (3)0.0027 (17)0.004 (2)0.032 (2)
C4'0.128 (4)0.054 (2)0.117 (3)0.021 (2)0.021 (3)0.001 (2)
C5'0.168 (4)0.050 (2)0.101 (3)0.022 (3)0.044 (3)0.010 (2)
C6'0.106 (3)0.054 (2)0.070 (2)0.010 (2)0.0229 (19)0.0025 (16)
C1''0.0412 (11)0.0269 (12)0.0413 (12)0.0021 (10)0.0055 (10)0.0039 (9)
C2''0.0719 (17)0.0382 (15)0.0524 (15)0.0052 (14)0.0059 (13)0.0087 (12)
C3''0.089 (2)0.0286 (14)0.083 (2)0.0108 (15)0.0110 (18)0.0108 (14)
C4''0.0712 (18)0.0291 (14)0.093 (2)0.0004 (14)0.0004 (17)0.0093 (15)
C5''0.0589 (15)0.0367 (14)0.0689 (17)0.0007 (13)0.0072 (14)0.0109 (13)
C6''0.0450 (12)0.0373 (14)0.0463 (13)0.0005 (11)0.0011 (10)0.0011 (11)
N10.115 (2)0.087 (2)0.0763 (19)0.014 (2)0.0178 (18)0.0409 (18)
N20.0414 (10)0.0371 (11)0.0335 (9)0.0000 (9)0.0076 (8)0.0006 (8)
N30.145 (3)0.0551 (16)0.0664 (16)0.0170 (19)0.0368 (18)0.0142 (14)
N40.0334 (8)0.0272 (10)0.0378 (9)0.0026 (8)0.0044 (7)0.0050 (8)
O10.1100 (17)0.0679 (14)0.0440 (10)0.0173 (14)0.0202 (11)0.0133 (10)
O20.0732 (11)0.0378 (10)0.0391 (9)0.0081 (9)0.0077 (8)0.0060 (7)
O30.0529 (9)0.0415 (10)0.0384 (8)0.0108 (8)0.0026 (7)0.0044 (7)
O40.0586 (10)0.0535 (11)0.0339 (8)0.0027 (9)0.0060 (8)0.0057 (8)
O50.0633 (11)0.0652 (12)0.0329 (8)0.0044 (10)0.0075 (8)0.0056 (8)
O60.0880 (14)0.0576 (13)0.0673 (12)0.0311 (12)0.0275 (11)0.0269 (10)
O70.0685 (11)0.0434 (11)0.0543 (10)0.0052 (9)0.0096 (9)0.0171 (9)
O80.0842 (13)0.0365 (9)0.0406 (9)0.0002 (9)0.0173 (9)0.0018 (8)
O90.0536 (9)0.0210 (7)0.0374 (8)0.0001 (7)0.0058 (7)0.0033 (6)
O100.0546 (9)0.0263 (8)0.0411 (8)0.0031 (7)0.0062 (8)0.0068 (7)
O110.0695 (11)0.0457 (10)0.0319 (8)0.0154 (9)0.0094 (8)0.0014 (7)
O120.0626 (10)0.0508 (11)0.0309 (8)0.0075 (9)0.0024 (7)0.0074 (7)
O130.0534 (9)0.0359 (9)0.0452 (9)0.0099 (8)0.0054 (8)0.0136 (7)
O140.0593 (10)0.0344 (9)0.0387 (8)0.0057 (8)0.0036 (8)0.0029 (7)
Geometric parameters (Å, º) top
C1—O71.431 (3)C29—H291.0000
C1—C21.530 (3)C30—C311.532 (3)
C1—C111.549 (3)C30—H30A0.9900
C1—H11.0000C30—H30B0.9900
C2—C31.512 (4)C31—C321.534 (3)
C2—H2A0.9900C31—C411.556 (3)
C2—H2B0.9900C31—H311.0000
C3—C41.504 (3)C32—O111.450 (3)
C3—H3A0.9900C32—C391.546 (3)
C3—H3B0.9900C32—C331.576 (3)
C4—O21.467 (3)C33—O141.419 (3)
C4—C51.538 (3)C33—C381.526 (3)
C4—C181.539 (3)C33—C341.554 (3)
C5—C61.548 (3)C34—C361.564 (3)
C5—C111.552 (3)C34—C351.566 (3)
C5—H51.0000C34—H341.0000
C6—C71.534 (3)C35—C411.535 (3)
C6—H6A0.9900C36—C371.543 (3)
C6—H6B0.9900C36—H36A0.9900
C7—C81.532 (3)C36—H36B0.9900
C7—C171.544 (3)C37—C381.514 (3)
C7—H71.0000C37—C401.536 (3)
C8—O41.441 (3)C37—H371.0000
C8—C151.546 (3)C38—O121.429 (3)
C8—C91.569 (3)C38—H381.0000
C9—O31.421 (3)C39—C401.536 (3)
C9—C141.511 (3)C39—H39A0.9900
C9—C101.551 (3)C39—H39B0.9900
C10—C121.565 (3)C40—O131.432 (3)
C10—C111.565 (3)C40—H401.0000
C10—H101.0000C41—N41.470 (3)
C11—C171.536 (3)C41—H411.0000
C12—C131.543 (4)C42—N41.466 (3)
C12—H12A0.9900C42—H42A0.9900
C12—H12B0.9900C42—H42B0.9900
C13—C141.513 (4)C43—O81.218 (3)
C13—C161.530 (4)C43—O91.346 (3)
C13—H131.0000C43—C1''1.467 (3)
C14—O51.427 (3)C44—O101.425 (3)
C14—H141.0000C44—H44A0.9800
C15—C161.526 (4)C44—H44B0.9800
C15—H15A0.9900C44—H44C0.9800
C15—H15B0.9900C45—O121.415 (3)
C16—O61.429 (3)C45—H45A0.9800
C16—H161.0000C45—H45B0.9800
C17—N21.474 (3)C45—H45C0.9800
C17—H171.0000C46—O131.411 (3)
C18—N21.462 (3)C46—H46A0.9800
C18—H18A0.9900C46—H46B0.9800
C18—H18B0.9900C46—H46C0.9800
C19—O11.217 (3)C47—N41.459 (3)
C19—O21.343 (3)C47—C481.507 (4)
C19—C1'1.478 (4)C47—H47A0.9900
C20—O71.409 (4)C47—H47B0.9900
C20—H20A0.9800C48—H48A0.9800
C20—H20B0.9800C48—H48B0.9800
C20—H20C0.9800C48—H48C0.9800
C21—O61.419 (4)C1'—C6'1.390 (4)
C21—H21A0.9800C1'—C2'1.408 (4)
C21—H21B0.9800C2'—N11.368 (4)
C21—H21C0.9800C2'—C3'1.395 (5)
C22—O51.403 (3)C3'—C4'1.364 (6)
C22—H22A0.9800C3'—H3'0.9500
C22—H22B0.9800C4'—C5'1.366 (5)
C22—H22C0.9800C4'—H4'0.9500
C23—N21.460 (3)C5'—C6'1.363 (5)
C23—C241.508 (4)C5'—H5'0.9500
C23—H23A0.9900C6'—H6'0.9500
C23—H23B0.9900C1''—C6''1.405 (3)
C24—H24A0.9800C1''—C2''1.406 (3)
C24—H24B0.9800C2''—N31.375 (4)
C24—H24C0.9800C2''—C3''1.400 (4)
C25—O101.421 (3)C3''—C4''1.372 (4)
C25—C261.535 (3)C3''—H3''0.9500
C25—C351.555 (3)C4''—C5''1.372 (4)
C25—H251.0000C4''—H4''0.9500
C26—C271.508 (3)C5''—C6''1.357 (3)
C26—H26A0.9900C5''—H5''0.9500
C26—H26B0.9900C6''—H6''0.9500
C27—C281.519 (3)N1—H1A0.9100
C27—H27A0.9900N1—H1B0.9100
C27—H27B0.9900N3—H3C0.9100
C28—O91.467 (2)N3—H3D0.9100
C28—C291.528 (3)O3—H30.8400
C28—C421.543 (3)O4—H40.8400
C29—C301.551 (3)O11—H110.8400
C29—C351.555 (3)O14—H14A0.9800
O7—C1—C2107.8 (2)C31—C30—C29105.27 (17)
O7—C1—C11108.43 (19)C31—C30—H30A110.7
C2—C1—C11117.1 (2)C29—C30—H30A110.7
O7—C1—H1107.7C31—C30—H30B110.7
C2—C1—H1107.7C29—C30—H30B110.7
C11—C1—H1107.7H30A—C30—H30B108.8
C3—C2—C1113.8 (2)C30—C31—C32111.15 (18)
C3—C2—H2A108.8C30—C31—C41102.96 (16)
C1—C2—H2A108.8C32—C31—C41110.98 (16)
C3—C2—H2B108.8C30—C31—H31110.5
C1—C2—H2B108.8C32—C31—H31110.5
H2A—C2—H2B107.7C41—C31—H31110.5
C4—C3—C2109.3 (2)O11—C32—C31105.12 (17)
C4—C3—H3A109.8O11—C32—C39107.97 (17)
C2—C3—H3A109.8C31—C32—C39112.04 (19)
C4—C3—H3B109.8O11—C32—C33108.49 (19)
C2—C3—H3B109.8C31—C32—C33110.21 (17)
H3A—C3—H3B108.3C39—C32—C33112.65 (18)
O2—C4—C3109.8 (2)O14—C33—C38111.30 (17)
O2—C4—C5101.74 (18)O14—C33—C34108.18 (17)
C3—C4—C5110.8 (2)C38—C33—C34102.86 (17)
O2—C4—C18110.4 (2)O14—C33—C32113.09 (19)
C3—C4—C18114.4 (2)C38—C33—C32109.54 (18)
C5—C4—C18108.98 (19)C34—C33—C32111.41 (17)
C4—C5—C6108.03 (19)C33—C34—C36103.19 (17)
C4—C5—C11108.83 (18)C33—C34—C35117.85 (16)
C6—C5—C11105.32 (17)C36—C34—C35116.19 (18)
C4—C5—H5111.5C33—C34—H34106.2
C6—C5—H5111.5C36—C34—H34106.2
C11—C5—H5111.5C35—C34—H34106.2
C7—C6—C5104.39 (17)C41—C35—C2998.14 (16)
C7—C6—H6A110.9C41—C35—C25116.01 (17)
C5—C6—H6A110.9C29—C35—C25112.82 (16)
C7—C6—H6B110.9C41—C35—C34110.27 (16)
C5—C6—H6B110.9C29—C35—C34111.05 (16)
H6A—C6—H6B108.9C25—C35—C34108.30 (16)
C8—C7—C6110.69 (18)C37—C36—C34106.70 (18)
C8—C7—C17111.72 (18)C37—C36—H36A110.4
C6—C7—C17103.77 (17)C34—C36—H36A110.4
C8—C7—H7110.2C37—C36—H36B110.4
C6—C7—H7110.2C34—C36—H36B110.4
C17—C7—H7110.2H36A—C36—H36B108.6
O4—C8—C7105.52 (18)C38—C37—C40113.19 (19)
O4—C8—C15108.17 (18)C38—C37—C3699.25 (18)
C7—C8—C15111.87 (19)C40—C37—C36110.85 (18)
O4—C8—C9108.27 (19)C38—C37—H37111.0
C7—C8—C9109.72 (18)C40—C37—H37111.0
C15—C8—C9112.9 (2)C36—C37—H37111.0
O3—C9—C14110.43 (18)O12—C38—C37118.60 (19)
O3—C9—C10108.94 (18)O12—C38—C33109.01 (18)
C14—C9—C10102.78 (19)C37—C38—C33102.50 (17)
O3—C9—C8112.8 (2)O12—C38—H38108.8
C14—C9—C8109.8 (2)C37—C38—H38108.8
C10—C9—C8111.68 (17)C33—C38—H38108.8
C9—C10—C12103.03 (19)C40—C39—C32118.16 (18)
C9—C10—C11117.51 (18)C40—C39—H39A107.8
C12—C10—C11115.81 (19)C32—C39—H39A107.8
C9—C10—H10106.6C40—C39—H39B107.8
C12—C10—H10106.6C32—C39—H39B107.8
C11—C10—H10106.6H39A—C39—H39B107.1
C17—C11—C1116.23 (18)O13—C40—C39110.64 (18)
C17—C11—C598.06 (18)O13—C40—C37108.11 (18)
C1—C11—C5112.57 (18)C39—C40—C37113.07 (19)
C17—C11—C10109.21 (17)O13—C40—H40108.3
C1—C11—C10108.58 (18)C39—C40—H40108.3
C5—C11—C10111.92 (18)C37—C40—H40108.3
C13—C12—C10106.9 (2)N4—C41—C35108.80 (16)
C13—C12—H12A110.3N4—C41—C31115.46 (16)
C10—C12—H12A110.3C35—C41—C31100.84 (16)
C13—C12—H12B110.3N4—C41—H41110.4
C10—C12—H12B110.3C35—C41—H41110.4
H12A—C12—H12B108.6C31—C41—H41110.4
C14—C13—C16112.5 (2)N4—C42—C28113.15 (17)
C14—C13—C1299.8 (2)N4—C42—H42A108.9
C16—C13—C12111.2 (2)C28—C42—H42A108.9
C14—C13—H13111.0N4—C42—H42B108.9
C16—C13—H13111.0C28—C42—H42B108.9
C12—C13—H13111.0H42A—C42—H42B107.8
O5—C14—C9108.6 (2)O8—C43—O9122.2 (2)
O5—C14—C13117.9 (2)O8—C43—C1''125.3 (2)
C9—C14—C13102.86 (19)O9—C43—C1''112.53 (19)
O5—C14—H14109.0O10—C44—H44A109.5
C9—C14—H14109.0O10—C44—H44B109.5
C13—C14—H14109.0H44A—C44—H44B109.5
C16—C15—C8119.1 (2)O10—C44—H44C109.5
C16—C15—H15A107.5H44A—C44—H44C109.5
C8—C15—H15A107.5H44B—C44—H44C109.5
C16—C15—H15B107.5O12—C45—H45A109.5
C8—C15—H15B107.5O12—C45—H45B109.5
H15A—C15—H15B107.0H45A—C45—H45B109.5
O6—C16—C15111.0 (2)O12—C45—H45C109.5
O6—C16—C13107.2 (2)H45A—C45—H45C109.5
C15—C16—C13113.5 (2)H45B—C45—H45C109.5
O6—C16—H16108.3O13—C46—H46A109.5
C15—C16—H16108.3O13—C46—H46B109.5
C13—C16—H16108.3H46A—C46—H46B109.5
N2—C17—C11108.60 (17)O13—C46—H46C109.5
N2—C17—C7115.47 (18)H46A—C46—H46C109.5
C11—C17—C7100.71 (17)H46B—C46—H46C109.5
N2—C17—H17110.5N4—C47—C48114.3 (2)
C11—C17—H17110.5N4—C47—H47A108.7
C7—C17—H17110.5C48—C47—H47A108.7
N2—C18—C4112.4 (2)N4—C47—H47B108.7
N2—C18—H18A109.1C48—C47—H47B108.7
C4—C18—H18A109.1H47A—C47—H47B107.6
N2—C18—H18B109.1C47—C48—H48A109.5
C4—C18—H18B109.1C47—C48—H48B109.5
H18A—C18—H18B107.8H48A—C48—H48B109.5
O1—C19—O2123.0 (3)C47—C48—H48C109.5
O1—C19—C1'125.6 (3)H48A—C48—H48C109.5
O2—C19—C1'111.4 (2)H48B—C48—H48C109.5
O7—C20—H20A109.5C6'—C1'—C2'118.2 (3)
O7—C20—H20B109.5C6'—C1'—C19119.7 (3)
H20A—C20—H20B109.5C2'—C1'—C19122.0 (3)
O7—C20—H20C109.5N1—C2'—C3'119.0 (3)
H20A—C20—H20C109.5N1—C2'—C1'122.4 (3)
H20B—C20—H20C109.5C3'—C2'—C1'118.6 (3)
O6—C21—H21A109.5C4'—C3'—C2'121.3 (3)
O6—C21—H21B109.5C4'—C3'—H3'119.3
H21A—C21—H21B109.5C2'—C3'—H3'119.3
O6—C21—H21C109.5C3'—C4'—C5'120.0 (4)
H21A—C21—H21C109.5C3'—C4'—H4'120.0
H21B—C21—H21C109.5C5'—C4'—H4'120.0
O5—C22—H22A109.5C6'—C5'—C4'120.1 (4)
O5—C22—H22B109.5C6'—C5'—H5'120.0
H22A—C22—H22B109.5C4'—C5'—H5'120.0
O5—C22—H22C109.5C5'—C6'—C1'121.7 (3)
H22A—C22—H22C109.5C5'—C6'—H6'119.1
H22B—C22—H22C109.5C1'—C6'—H6'119.1
N2—C23—C24113.5 (2)C6''—C1''—C2''118.3 (2)
N2—C23—H23A108.9C6''—C1''—C43120.7 (2)
C24—C23—H23A108.9C2''—C1''—C43120.9 (2)
N2—C23—H23B108.9N3—C2''—C3''119.9 (3)
C24—C23—H23B108.9N3—C2''—C1''122.0 (3)
H23A—C23—H23B107.7C3''—C2''—C1''118.1 (3)
C23—C24—H24A109.5C4''—C3''—C2''121.7 (3)
C23—C24—H24B109.5C4''—C3''—H3''119.2
H24A—C24—H24B109.5C2''—C3''—H3''119.2
C23—C24—H24C109.5C3''—C4''—C5''120.1 (3)
H24A—C24—H24C109.5C3''—C4''—H4''120.0
H24B—C24—H24C109.5C5''—C4''—H4''120.0
O10—C25—C26108.00 (17)C6''—C5''—C4''119.7 (3)
O10—C25—C35109.78 (16)C6''—C5''—H5''120.1
C26—C25—C35116.81 (17)C4''—C5''—H5''120.1
O10—C25—H25107.3C5''—C6''—C1''122.1 (2)
C26—C25—H25107.3C5''—C6''—H6''119.0
C35—C25—H25107.3C1''—C6''—H6''119.0
C27—C26—C25113.19 (19)C2'—N1—H1A108.9
C27—C26—H26A108.9C2'—N1—H1B109.3
C25—C26—H26A108.9H1A—N1—H1B109.5
C27—C26—H26B108.9C23—N2—C18111.77 (19)
C25—C26—H26B108.9C23—N2—C17114.02 (19)
H26A—C26—H26B107.8C18—N2—C17116.80 (18)
C26—C27—C28109.07 (18)C2''—N3—H3C108.5
C26—C27—H27A109.9C2''—N3—H3D109.0
C28—C27—H27A109.9H3C—N3—H3D109.5
C26—C27—H27B109.9C47—N4—C42109.67 (17)
C28—C27—H27B109.9C47—N4—C41114.24 (17)
H27A—C27—H27B108.3C42—N4—C41117.19 (17)
O9—C28—C27109.62 (17)C19—O2—C4124.4 (2)
O9—C28—C29102.89 (16)C9—O3—H3109.5
C27—C28—C29110.14 (18)C8—O4—H4109.5
O9—C28—C42110.62 (17)C22—O5—C14113.9 (2)
C27—C28—C42114.03 (18)C21—O6—C16112.6 (2)
C29—C28—C42108.97 (17)C20—O7—C1114.2 (2)
C28—C29—C30108.75 (17)C43—O9—C28122.13 (17)
C28—C29—C35109.14 (17)C25—O10—C44113.1 (2)
C30—C29—C35104.76 (17)C32—O11—H11109.4
C28—C29—H29111.3C45—O12—C38112.77 (19)
C30—C29—H29111.3C46—O13—C40112.65 (18)
C35—C29—H29111.3C33—O14—H14A109.3
O7—C1—C2—C3161.3 (2)O14—C33—C34—C3589.7 (2)
C11—C1—C2—C338.9 (3)C38—C33—C34—C35152.49 (18)
C1—C2—C3—C451.2 (3)C32—C33—C34—C3535.2 (3)
C2—C3—C4—O2177.0 (2)C28—C29—C35—C4174.90 (19)
C2—C3—C4—C565.4 (3)C30—C29—C35—C4141.42 (19)
C2—C3—C4—C1858.2 (3)C28—C29—C35—C2547.8 (2)
O2—C4—C5—C665.3 (2)C30—C29—C35—C25164.15 (17)
C3—C4—C5—C6178.0 (2)C28—C29—C35—C34169.64 (16)
C18—C4—C5—C651.3 (2)C30—C29—C35—C3474.0 (2)
O2—C4—C5—C11179.17 (18)O10—C25—C35—C4148.4 (2)
C3—C4—C5—C1164.2 (3)C26—C25—C35—C4174.9 (2)
C18—C4—C5—C1162.5 (2)O10—C25—C35—C29160.53 (17)
C4—C5—C6—C7101.3 (2)C26—C25—C35—C2937.2 (3)
C11—C5—C6—C714.9 (2)O10—C25—C35—C3476.1 (2)
C5—C6—C7—C8102.43 (19)C26—C25—C35—C34160.53 (19)
C5—C6—C7—C1717.6 (2)C33—C34—C35—C4149.7 (2)
C6—C7—C8—O464.9 (2)C36—C34—C35—C4173.5 (2)
C17—C7—C8—O4179.98 (18)C33—C34—C35—C2958.0 (2)
C6—C7—C8—C15177.73 (19)C36—C34—C35—C29178.83 (17)
C17—C7—C8—C1562.6 (2)C33—C34—C35—C25177.63 (18)
C6—C7—C8—C951.6 (2)C36—C34—C35—C2554.4 (2)
C17—C7—C8—C963.5 (2)C33—C34—C36—C377.3 (2)
O4—C8—C9—O331.9 (2)C35—C34—C36—C37123.20 (19)
C7—C8—C9—O382.8 (2)C34—C36—C37—C3834.7 (2)
C15—C8—C9—O3151.70 (19)C34—C36—C37—C4084.5 (2)
O4—C8—C9—C1491.7 (2)C40—C37—C38—O1252.1 (3)
C7—C8—C9—C14153.64 (19)C36—C37—C38—O12169.60 (18)
C15—C8—C9—C1428.1 (3)C40—C37—C38—C3368.0 (2)
O4—C8—C9—C10155.01 (18)C36—C37—C38—C3349.5 (2)
C7—C8—C9—C1040.3 (3)O14—C33—C38—O1271.7 (2)
C15—C8—C9—C1085.2 (2)C34—C33—C38—O12172.71 (17)
O3—C9—C10—C12143.00 (19)C32—C33—C38—O1254.1 (2)
C14—C9—C10—C1225.9 (2)O14—C33—C38—C37161.82 (18)
C8—C9—C10—C1291.8 (2)C34—C33—C38—C3746.2 (2)
O3—C9—C10—C1188.4 (2)C32—C33—C38—C3772.4 (2)
C14—C9—C10—C11154.5 (2)O11—C32—C39—C40143.67 (19)
C8—C9—C10—C1136.9 (3)C31—C32—C39—C40101.0 (2)
O7—C1—C11—C1747.8 (3)C33—C32—C39—C4023.9 (3)
C2—C1—C11—C1774.3 (3)C32—C39—C40—O13150.93 (19)
O7—C1—C11—C5159.75 (19)C32—C39—C40—C3729.5 (3)
C2—C1—C11—C537.6 (3)C38—C37—C40—O13105.1 (2)
O7—C1—C11—C1075.8 (2)C36—C37—C40—O13144.42 (19)
C2—C1—C11—C10162.1 (2)C38—C37—C40—C3917.8 (3)
C4—C5—C11—C1774.4 (2)C36—C37—C40—C3992.7 (2)
C6—C5—C11—C1741.2 (2)C29—C35—C41—N469.81 (19)
C4—C5—C11—C148.4 (2)C25—C35—C41—N450.6 (2)
C6—C5—C11—C1164.07 (18)C34—C35—C41—N4174.11 (16)
C4—C5—C11—C10171.08 (18)C29—C35—C41—C3152.03 (17)
C6—C5—C11—C1073.3 (2)C25—C35—C41—C31172.41 (16)
C9—C10—C11—C1751.6 (3)C34—C35—C41—C3164.05 (19)
C12—C10—C11—C1770.7 (3)C30—C31—C41—N473.1 (2)
C9—C10—C11—C1179.26 (19)C32—C31—C41—N4167.96 (17)
C12—C10—C11—C157.0 (3)C30—C31—C41—C3543.99 (19)
C9—C10—C11—C555.9 (3)C32—C31—C41—C3575.0 (2)
C12—C10—C11—C5178.2 (2)O9—C28—C42—N4153.09 (17)
C9—C10—C12—C133.5 (2)C27—C28—C42—N482.8 (2)
C11—C10—C12—C13126.2 (2)C29—C28—C42—N440.7 (2)
C10—C12—C13—C1431.2 (3)O1—C19—C1'—C6'179.2 (3)
C10—C12—C13—C1687.7 (3)O2—C19—C1'—C6'0.1 (4)
O3—C9—C14—O571.1 (2)O1—C19—C1'—C2'3.2 (5)
C10—C9—C14—O5172.86 (18)O2—C19—C1'—C2'176.2 (3)
C8—C9—C14—O553.9 (3)C6'—C1'—C2'—N1179.3 (3)
O3—C9—C14—C13163.2 (2)C19—C1'—C2'—N14.6 (5)
C10—C9—C14—C1347.2 (2)C6'—C1'—C2'—C3'1.6 (4)
C8—C9—C14—C1371.8 (2)C19—C1'—C2'—C3'174.5 (3)
C16—C13—C14—O549.6 (3)N1—C2'—C3'—C4'179.0 (4)
C12—C13—C14—O5167.5 (2)C1'—C2'—C3'—C4'1.9 (5)
C16—C13—C14—C969.9 (3)C2'—C3'—C4'—C5'0.3 (7)
C12—C13—C14—C948.1 (2)C3'—C4'—C5'—C6'1.4 (8)
O4—C8—C15—C16140.2 (2)C4'—C5'—C6'—C1'1.6 (8)
C7—C8—C15—C16104.0 (2)C2'—C1'—C6'—C5'0.1 (6)
C9—C8—C15—C1620.4 (3)C19—C1'—C6'—C5'176.3 (4)
C8—C15—C16—O6144.3 (2)O8—C43—C1''—C6''174.7 (2)
C8—C15—C16—C1323.5 (3)O9—C43—C1''—C6''4.4 (3)
C14—C13—C16—O6100.5 (3)O8—C43—C1''—C2''3.5 (4)
C12—C13—C16—O6148.5 (2)O9—C43—C1''—C2''177.4 (2)
C14—C13—C16—C1522.4 (3)C6''—C1''—C2''—N3178.6 (3)
C12—C13—C16—C1588.6 (3)C43—C1''—C2''—N33.1 (4)
C1—C11—C17—N250.0 (3)C6''—C1''—C2''—C3''0.6 (4)
C5—C11—C17—N270.1 (2)C43—C1''—C2''—C3''178.9 (3)
C10—C11—C17—N2173.27 (17)N3—C2''—C3''—C4''179.6 (3)
C1—C11—C17—C7171.74 (19)C1''—C2''—C3''—C4''1.6 (5)
C5—C11—C17—C751.62 (19)C2''—C3''—C4''—C5''1.8 (5)
C10—C11—C17—C765.0 (2)C3''—C4''—C5''—C6''1.1 (5)
C8—C7—C17—N2167.96 (18)C4''—C5''—C6''—C1''0.2 (4)
C6—C7—C17—N272.8 (2)C2''—C1''—C6''—C5''0.0 (4)
C8—C7—C17—C1175.3 (2)C43—C1''—C6''—C5''178.3 (2)
C6—C7—C17—C1144.0 (2)C24—C23—N2—C18157.0 (2)
O2—C4—C18—N2153.59 (18)C24—C23—N2—C1767.8 (3)
C3—C4—C18—N282.0 (3)C4—C18—N2—C23176.49 (19)
C5—C4—C18—N242.6 (3)C4—C18—N2—C1742.6 (3)
O10—C25—C26—C27164.22 (19)C11—C17—N2—C23168.01 (19)
C35—C25—C26—C2740.0 (3)C7—C17—N2—C2379.8 (3)
C25—C26—C27—C2853.2 (3)C11—C17—N2—C1859.1 (2)
C26—C27—C28—O9179.43 (18)C7—C17—N2—C1853.0 (3)
C26—C27—C28—C2966.9 (2)C48—C47—N4—C42165.8 (2)
C26—C27—C28—C4255.9 (3)C48—C47—N4—C4160.4 (3)
O9—C28—C29—C3065.5 (2)C28—C42—N4—C47172.51 (19)
C27—C28—C29—C30177.69 (18)C28—C42—N4—C4140.2 (2)
C42—C28—C29—C3051.9 (2)C35—C41—N4—C47172.30 (19)
O9—C28—C29—C35179.26 (16)C31—C41—N4—C4775.2 (2)
C27—C28—C29—C3563.9 (2)C35—C41—N4—C4257.4 (2)
C42—C28—C29—C3561.8 (2)C31—C41—N4—C4255.0 (2)
C28—C29—C30—C31101.63 (19)O1—C19—O2—C47.9 (4)
C35—C29—C30—C3115.0 (2)C1'—C19—O2—C4171.5 (2)
C29—C30—C31—C32101.46 (19)C3—C4—O2—C1973.0 (3)
C29—C30—C31—C4117.4 (2)C5—C4—O2—C19169.6 (2)
C30—C31—C32—O1167.1 (2)C18—C4—O2—C1954.0 (3)
C41—C31—C32—O11179.00 (17)C9—C14—O5—C22160.9 (3)
C30—C31—C32—C39175.93 (17)C13—C14—O5—C2282.7 (3)
C41—C31—C32—C3962.0 (2)C15—C16—O6—C2168.2 (4)
C30—C31—C32—C3349.7 (2)C13—C16—O6—C21167.3 (3)
C41—C31—C32—C3364.3 (2)C2—C1—O7—C2081.8 (3)
O11—C32—C33—O1433.1 (2)C11—C1—O7—C20150.6 (3)
C31—C32—C33—O1481.5 (2)O8—C43—O9—C283.2 (3)
C39—C32—C33—O14152.54 (18)C1''—C43—O9—C28177.64 (18)
O11—C32—C33—C3891.7 (2)C27—C28—O9—C4370.0 (2)
C31—C32—C33—C38153.70 (18)C29—C28—O9—C43172.83 (18)
C39—C32—C33—C3827.8 (2)C42—C28—O9—C4356.6 (2)
O11—C32—C33—C34155.17 (17)C26—C25—O10—C4479.8 (2)
C31—C32—C33—C3440.6 (2)C35—C25—O10—C44151.8 (2)
C39—C32—C33—C3485.4 (2)C37—C38—O12—C4564.2 (3)
O14—C33—C34—C36140.79 (18)C33—C38—O12—C45179.2 (2)
C38—C33—C34—C3622.9 (2)C39—C40—O13—C4675.9 (3)
C32—C33—C34—C3694.3 (2)C37—C40—O13—C46159.8 (2)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
O14—H14A···O6i0.982.272.927 (2)123
O11—H11···O120.842.402.944 (2)124
O4—H4···O50.842.332.914 (3)127
O3—H3···O13ii0.842.413.095 (2)139
N3—H3D···O80.912.022.687 (3)129
N1—H1A···O10.912.022.752 (4)137
Symmetry codes: (i) x+1/2, y+1, z+1/2; (ii) x+1/2, y, z1/2.
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
O14—H14A···O6i0.982.272.927 (2)123.2
O11—H11···O120.842.402.944 (2)123.5
O4—H4···O50.842.332.914 (3)126.8
O3—H3···O13ii0.842.413.095 (2)138.8
N3—H3D···O80.912.022.687 (3)129.3
N1—H1A···O10.912.022.752 (4)136.7
Symmetry codes: (i) x+1/2, y+1, z+1/2; (ii) x+1/2, y, z1/2.
 

Acknowledgements

This project was supported by the Science and Technology Research and Development Projects of Shaanxi Province (grant No. 2013KJXX-74), the National Natural Science Foundation of China (grant No. 31200257) and the West Light Foundation of The Chinese Academy of Sciences (grant No. 2012DF05).

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