research communications
E)-styryl]-1,3,4-oxathiazol-2-one
determination as part of an ongoing undergraduate organic laboratory project: 5-[(aDepartment of Chemistry, Crandall University, PO Box 6004, Moncton, New Brunswick, Canada, and bThe Atlantic Centre for Green Chemistry and the Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, Canada
*Correspondence e-mail: mel.schriver@crandallu.ca
The title compound, C10H7NO2S, provides the first structure of an α-alkenyl oxathiazolone ring. The phenyl ring and the oxathiazolone groups make dihedral angles of 0.3 (3) and −2.8 (3)°, respectively, with the plane of the central alkene group; the dihedral angle between the rings is 2.68 (8)°. A careful consideration of bond lengths provides insight into the electronic structure and reactivity of the title compound. In the crystal, extended π-stacking is observed parallel to the a-axis direction, consisting of cofacial head-to-tail dimeric units [centroid–centroid distance of 3.6191 (11) Å]. These dimeric units are separated by a slightly longer centroid–centroid distance of 3.8383 (12) Å, generating infinite stacks of molecules.
Keywords: crystal structure; oxathiazolone; nitrile sulfide; styryl; cinnamamide; conjugations.
CCDC reference: 1565845
1. Chemical context
A common feature of the undergraduate organic chemistry teaching laboratory is the capstone, multi-step synthetic project that allows the student to integrate their lecture and laboratory experiences and capture a glimpse of research chemistry (Christiansen et al., 2014). The selection of an appropriate project target compound requires reliable syntheses coupled to definitive characterizations and, if possible, real-world applications. In our teaching laboratory, we have focused our student projects on the preparation, characterization and chemistry of oxathiazolone derivatives. This project compliments the lecture sections on carbonyl and heterocycle chemistry at the end of a one semester introductory organic chemistry course. The preparations of oxathiazolone derivatives use methods developed in earlier laboratories and allow for subsequent chemistry of either the heterocycle or substituent group, which can be explored in a three-to-four week project cycle individually, in groups and in inquiry-based class projects. The existing literature on the oxathiazolone heterocycle is sufficient but not overwhelming for the research purposes of the students. In addition, the area has been the subject of several comprehensive reviews and theses (Paton, 1989; Wentrup & Kambouris, 1991).
Derivatives of the oxathiazolone heterocycle have been known since their first preparation in 1967 by Muhlbauer and Weiss (Muhlbauer & Weiss, 1967). Until recently, the predominant chemistry of the heterocycle was the thermal cycloreversion to the short-lived nitrile sulfide, a propargyl allenyl 1,3-dipole which could be trapped by electron-deficient π-bonds in reasonable yield to give families of new heterocycles (Paton, 1989). Industrially, various derivatives of the oxathiazolone heterocycle have been reported as potential fungicides (Klaus et al., 1965), pesticides (Hölzl & Schnyder, 2004), polymer additives (Crosby 1978) and pharmaceuticals (Russo et al., 2015). In 2009, interest was renewed in the ring system with the report of the use of oxathiazolone derivatives as selective inhibitors for mycobacterial proteasomes (Lin et al., 2009). Subsequent research has uncovered potential use of styryl-substituted oxathiazolone derivatives as antitubercular `warheads' (Russo et al., 2015). The significance of the structure and chemistry of styryl-substituted oxathiazolone molecules, especially with respect to their intermolecular interactions with the proteasome, has therefore placed some significance on the structure of the title compound.
The title compound was first prepared from cinnamyl amide by Paton and coworkers (Paton et al., 1983) and the synthesis was subsequently reported in a patent for use as modulating agents for amino acid receptors (Cosford et al., 2005). Our interest in this derivative of the oxathiazolone heterocycle was initially focused on the potential for exploring the chemistry of the alkene moiety in the styryl group for subsequent assessment of the substituent effect of the oxathiazolone on the alkene addition and electrophilic substitution chemistry.
2. Structural commentary
The influence of oxathiazolone and substituent π-conjugation on the bonding in the heterocycle has been shown spectroscopically (Markgraf et al., 2007) and crystallographically (Krayushkin et al., 2010a; Krayushkin et al., 2010b) to isolate the C=N π-system from the nascent O=C=O π-system foreshadowing the facile decarboxylation to the nitrile sulfide. Thus the asymmetry of the C—O bonds within the heterocycle has been linked to the ease of nitrile sulfide generation. It has been proposed that the ease of decarboxylation is related to the length of the C1—O2 bond.
The title compound (Fig. 1) is the first oxathiazolone X-ray structure of the heterocycle substituted directly to an alkene. The C—O bonds within the heterocycle [C1—O1 = 1.3852 (19), C2—O1 = 1.3678 (17) Å] are asymmetric as expected with conjugation between the alkene and the heterocycle. The bond distances and angles are consistent with the known oxathiazolone derivatives that feature a Csp2—Csp2 bond between the heterocycle and the unsaturated organic substituent. The C1—O1 bond [1.3852 (19) Å] is close to the statistical average for molecules of this type (1.40±0.03 Å) and significantly longer than the average for molecules that feature a Csp2—Csp3 bond between the heterocycle and the saturated organic substituent (1.374±0.005 Å). In addition, the C1—S1 bond [1.7379 (18) Å] is slightly shorter than the statistical average for molecules of this type (1.75±0.02 Å). Thus the pattern of bonding within the heterocycle is consistent with the Krayuskin conjugation model, leading to the hypothesis that decarbonylation of this derivative should occur with milder conditions than observed for heterocycles substituted with saturated substituents.
The atoms in the ring of the oxathiazolone heterocycle form bond angles that sum to 540.0° consistent with a planar ring (ideal 540°). The torsion angles O1—C2—C3—C4 [−2.8 (3)°] and C3—C4—C5—C6 [−179.81 (17)°] confirm a near planarity of the molecule favorable for conjugation between the π-systems of the two rings and the central alkene.
The planarity, bond lengths and angles in the styryl fragment are comparable with previously reported values (Nilofar Nissa et al., 2002; Iwamoto et al., 1989). The widening of the C3—C4—C5 angle to 125.68 (14)° has been previously attributed to intramolecular repulsion between C3 and C6 (Subramanian et al., 1999). The C2—C3 distance [1.443 (2) Å] is shorter than observed in cinnamyl derivatives (Nilofar Nissa et al., 2002), consistent with π-delocalization between the alkene and the heterocycle.
3. Supramolecular features
Extended π-stacking is observed parallel to the a-axis direction (Fig. 2, top), consisting of cofacial head-to-tail dimeric units [centroid–centroid distance of 3.6191 (11) Å]. These dimeric units are separated by a slightly longer centroid–centroid distance of 3.8383 (12) Å (Fig. 2, bottom). It should be noted, however, that the intermolecular S⋯N distances [3.6879 (16) Å], are significantly longer than those observed in other related S⋯N heterocyclic molecules (Bridson et al., 1995).
4. Database survey
There are eleven crystal structures of oxathiazolone derivatives reported in the literature (Schriver & Zaworotko, 1995; Bridson et al. 1994, 1995; Vorontsova et al., 1996; McMillan et al., 2006; Krayushkin et al., 2010a,b), which have been partially reviewed (Krayushkin et al., 2010a,b). The structures fall into two groups: those that feature a Csp2—Csp3 bond between the heterocycle and the saturated organic substituent and those that feature a Csp2—Csp2 bond between the heterocycle and the unsaturated organic substituent (either a phenyl group or a heterocyclic ring).
5. Synthesis and crystallization
The title compound was prepared following literature methods (Cosford et al., 2005) and was crystallized as large needles from a hot solution in chloroform by cooling to room temperature followed by slow evaporation to a crystalline solid. The identity and purity of the product was determined by comparison with the literature (Paton et al., 1983; Cosford et al., 2005) and by UV–visible spectroscopy (CH2Cl2) λmax (log ∊) : 228 nm (4.21), 307 nm (4.52).
6. Refinement
Crystal data, data collection and structure .
details are summarized in Table 1Supporting information
CCDC reference: 1565845
https://doi.org/10.1107/S2056989017011264/hb7694sup1.cif
contains datablock I. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989017011264/hb7694Isup2.hkl
Supporting information file. DOI: https://doi.org/10.1107/S2056989017011264/hb7694Isup3.cml
Data collection: SAINT (Bruker, 2009); cell
APEX2 (Bruker, 2009); data reduction: APEX2 (Bruker, 2009); program(s) used to solve structure: SHELXS2016 (Sheldrick, 2008); program(s) used to refine structure: SHELXL2016 (Sheldrick, 2015); molecular graphics: OLEX2 (Dolomanov et al., 2009); software used to prepare material for publication: OLEX2 (Dolomanov et al., 2009).C10H7NO2S | F(000) = 424 |
Mr = 205.23 | Dx = 1.449 Mg m−3 |
Monoclinic, P21/n | Mo Kα radiation, λ = 0.71073 Å |
a = 7.3948 (11) Å | Cell parameters from 4030 reflections |
b = 9.4609 (13) Å | θ = 2.6–28.6° |
c = 13.5183 (19) Å | µ = 0.31 mm−1 |
β = 95.771 (2)° | T = 296 K |
V = 941.0 (2) Å3 | Needle, pink |
Z = 4 | 0.46 × 0.21 × 0.15 mm |
Bruker APEXII CCD diffractometer | 1730 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.014 |
φ and ω scans | θmax = 27.0°, θmin = 2.6° |
Absorption correction: multi-scan (SADABS; Bruker, 2008) | h = −9→7 |
Tmin = 0.637, Tmax = 0.746 | k = −12→12 |
7073 measured reflections | l = −17→17 |
2046 independent reflections |
Refinement on F2 | 0 restraints |
Least-squares matrix: full | Hydrogen site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.040 | All H-atom parameters refined |
wR(F2) = 0.107 | w = 1/[σ2(Fo2) + (0.0533P)2 + 0.2083P] where P = (Fo2 + 2Fc2)/3 |
S = 1.07 | (Δ/σ)max < 0.001 |
2046 reflections | Δρmax = 0.40 e Å−3 |
155 parameters | Δρmin = −0.18 e Å−3 |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
x | y | z | Uiso*/Ueq | ||
S1 | 0.08082 (8) | 1.41478 (5) | 0.37424 (4) | 0.0704 (2) | |
O1 | 0.15697 (16) | 1.15722 (11) | 0.35689 (7) | 0.0552 (3) | |
O2 | 0.0742 (2) | 1.26055 (17) | 0.20881 (10) | 0.0880 (5) | |
N1 | 0.1444 (2) | 1.32282 (16) | 0.47790 (10) | 0.0662 (4) | |
C1 | 0.1007 (2) | 1.27047 (19) | 0.29653 (12) | 0.0590 (4) | |
C2 | 0.1790 (2) | 1.19553 (16) | 0.45493 (11) | 0.0492 (3) | |
C3 | 0.2399 (2) | 1.08768 (17) | 0.52613 (11) | 0.0519 (4) | |
H3 | 0.262 (3) | 1.122 (2) | 0.5907 (14) | 0.068 (5)* | |
C4 | 0.2691 (2) | 0.95350 (17) | 0.50461 (11) | 0.0490 (3) | |
H4 | 0.250 (3) | 0.9270 (18) | 0.4370 (15) | 0.065 (5)* | |
C5 | 0.3301 (2) | 0.84338 (15) | 0.57630 (10) | 0.0465 (3) | |
C6 | 0.3561 (3) | 0.70636 (18) | 0.54358 (13) | 0.0614 (4) | |
H6 | 0.333 (3) | 0.689 (2) | 0.4764 (16) | 0.082 (6)* | |
C7 | 0.4143 (3) | 0.60037 (19) | 0.60958 (15) | 0.0693 (5) | |
H7 | 0.430 (3) | 0.509 (2) | 0.5866 (16) | 0.082 (6)* | |
C8 | 0.4481 (3) | 0.6292 (2) | 0.70893 (14) | 0.0628 (4) | |
H8 | 0.485 (3) | 0.559 (2) | 0.7506 (15) | 0.070 (6)* | |
C9 | 0.4223 (3) | 0.7643 (2) | 0.74363 (13) | 0.0644 (5) | |
H9 | 0.446 (3) | 0.786 (2) | 0.8132 (16) | 0.077 (6)* | |
C10 | 0.3636 (2) | 0.87006 (18) | 0.67792 (12) | 0.0567 (4) | |
H10 | 0.347 (3) | 0.958 (2) | 0.7007 (14) | 0.068 (5)* |
U11 | U22 | U33 | U12 | U13 | U23 | |
S1 | 0.0899 (4) | 0.0566 (3) | 0.0630 (3) | 0.0181 (2) | 0.0000 (2) | 0.00692 (19) |
O1 | 0.0711 (7) | 0.0519 (6) | 0.0415 (5) | 0.0005 (5) | −0.0001 (5) | −0.0008 (4) |
O2 | 0.1246 (13) | 0.0903 (10) | 0.0463 (7) | 0.0098 (9) | −0.0056 (7) | 0.0081 (7) |
N1 | 0.0902 (11) | 0.0561 (8) | 0.0505 (8) | 0.0147 (7) | −0.0019 (7) | −0.0012 (6) |
C1 | 0.0655 (10) | 0.0617 (10) | 0.0488 (9) | 0.0014 (8) | 0.0009 (7) | 0.0065 (7) |
C2 | 0.0529 (8) | 0.0516 (8) | 0.0426 (7) | 0.0002 (6) | 0.0021 (6) | −0.0026 (6) |
C3 | 0.0588 (9) | 0.0546 (9) | 0.0415 (7) | 0.0022 (7) | 0.0002 (6) | −0.0003 (6) |
C4 | 0.0525 (8) | 0.0525 (8) | 0.0414 (7) | −0.0031 (6) | 0.0027 (6) | −0.0010 (6) |
C5 | 0.0465 (8) | 0.0483 (8) | 0.0453 (7) | −0.0044 (6) | 0.0075 (6) | 0.0001 (6) |
C6 | 0.0801 (12) | 0.0529 (9) | 0.0522 (9) | 0.0014 (8) | 0.0113 (8) | −0.0050 (7) |
C7 | 0.0875 (14) | 0.0473 (9) | 0.0745 (12) | 0.0062 (8) | 0.0148 (10) | −0.0009 (8) |
C8 | 0.0669 (11) | 0.0542 (9) | 0.0670 (11) | 0.0008 (8) | 0.0049 (8) | 0.0164 (8) |
C9 | 0.0818 (12) | 0.0600 (10) | 0.0494 (9) | −0.0053 (8) | −0.0029 (8) | 0.0057 (7) |
C10 | 0.0739 (11) | 0.0476 (8) | 0.0477 (8) | −0.0020 (7) | 0.0013 (7) | −0.0019 (6) |
S1—N1 | 1.6761 (14) | C5—C6 | 1.389 (2) |
S1—C1 | 1.7379 (18) | C5—C10 | 1.394 (2) |
O1—C1 | 1.3852 (19) | C6—H6 | 0.92 (2) |
O1—C2 | 1.3678 (17) | C6—C7 | 1.382 (3) |
O2—C1 | 1.186 (2) | C7—H7 | 0.93 (2) |
N1—C2 | 1.276 (2) | C7—C8 | 1.369 (3) |
C2—C3 | 1.443 (2) | C8—H8 | 0.90 (2) |
C3—H3 | 0.930 (19) | C8—C9 | 1.381 (3) |
C3—C4 | 1.325 (2) | C9—H9 | 0.96 (2) |
C4—H4 | 0.944 (19) | C9—C10 | 1.379 (2) |
C4—C5 | 1.463 (2) | C10—H10 | 0.90 (2) |
N1—S1—C1 | 93.67 (8) | C10—C5—C4 | 122.42 (14) |
C2—O1—C1 | 111.43 (12) | C5—C6—H6 | 117.6 (14) |
C2—N1—S1 | 109.43 (11) | C7—C6—C5 | 121.04 (16) |
O1—C1—S1 | 106.87 (11) | C7—C6—H6 | 121.3 (14) |
O2—C1—S1 | 130.62 (15) | C6—C7—H7 | 120.1 (13) |
O2—C1—O1 | 122.51 (17) | C8—C7—C6 | 120.22 (17) |
O1—C2—C3 | 117.23 (13) | C8—C7—H7 | 119.7 (13) |
N1—C2—O1 | 118.60 (14) | C7—C8—H8 | 118.8 (13) |
N1—C2—C3 | 124.17 (14) | C7—C8—C9 | 119.98 (17) |
C2—C3—H3 | 113.2 (12) | C9—C8—H8 | 121.2 (13) |
C4—C3—C2 | 125.30 (14) | C8—C9—H9 | 121.0 (13) |
C4—C3—H3 | 121.4 (12) | C10—C9—C8 | 119.87 (17) |
C3—C4—H4 | 117.1 (11) | C10—C9—H9 | 119.1 (13) |
C3—C4—C5 | 125.68 (14) | C5—C10—H10 | 119.1 (12) |
C5—C4—H4 | 117.3 (11) | C9—C10—C5 | 121.11 (16) |
C6—C5—C4 | 119.80 (13) | C9—C10—H10 | 119.8 (12) |
C6—C5—C10 | 117.78 (15) | ||
S1—N1—C2—O1 | −1.1 (2) | C2—C3—C4—C5 | −179.74 (15) |
S1—N1—C2—C3 | 179.16 (13) | C3—C4—C5—C6 | −179.81 (17) |
O1—C2—C3—C4 | −2.8 (3) | C3—C4—C5—C10 | 0.3 (3) |
N1—S1—C1—O1 | −0.10 (13) | C4—C5—C6—C7 | 179.74 (17) |
N1—S1—C1—O2 | 179.8 (2) | C4—C5—C10—C9 | −179.52 (16) |
N1—C2—C3—C4 | 176.93 (18) | C5—C6—C7—C8 | −0.2 (3) |
C1—S1—N1—C2 | 0.65 (15) | C6—C5—C10—C9 | 0.6 (3) |
C1—O1—C2—N1 | 1.0 (2) | C6—C7—C8—C9 | 0.6 (3) |
C1—O1—C2—C3 | −179.19 (14) | C7—C8—C9—C10 | −0.4 (3) |
C2—O1—C1—S1 | −0.45 (16) | C8—C9—C10—C5 | −0.2 (3) |
C2—O1—C1—O2 | 179.68 (17) | C10—C5—C6—C7 | −0.4 (3) |
Acknowledgements
TRN and MJS would like to acknowledge the work of many student co-workers in the course Chemistry 2113 who worked on the oxathiazolone synthesis and characterization project and the support of Crandall University. MS would like to acknowledge the Stephen and Ella Steeves Research Fund for operating funds. JDM would like to acknowledge the Canadian Foundation for Innovation Leaders Opportunity fund (CFI–LFO) for upgrades to the diffractometer, the Natural Science and Engineering Council of Canada (NSERC) for operating funds and Saint Mary's University for support.
Funding information
Funding for this research was provided by: Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation.
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