Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzyl­idene-N-methyl-2-(thio­phen-2-yl)acetohydrazides

Cardoso, L.N.F.; Noguiera, T.C.M.; Kaiser, C.R.; Wardell, J.L.; Souza, M.V.N. de; Harrison, W.T.A.

doi:10.1107/S2056989017014384

research communications

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ISSN: 2056-9890

Volume 73| Part 11| November 2017| Pages 1636-1641

https://doi.org/10.1107/S2056989017014384

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Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzylidene-N-methyl-2-(thiophen-2-yl)acetohydrazides

Laura N. F. Cardoso,^a,^b Thais C. M. Noguiera,^a Carlos R. Kaiser,^b James L. Wardell,^a,^c Marcus V. N. de Souza ^a and William T. A. Harrison ^c ^*

^aFundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos–FarManguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro, Brazil, ^bInstituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Brazil, and ^cDepartment of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland
^*Correspondence e-mail: w.harrison@abdn.ac.uk

Edited by L. Van Meervelt, Katholieke Universiteit Leuven, Belgium (Received 29 September 2017; accepted 5 October 2017; online 13 October 2017)

The syntheses and crystal structures of (E)-N′-(3-cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C₁₅H₁₃N₃OS, (I), and (E)-N′-(4-methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C₁₅H₁₆N₂O₂S, (II), with different substituents in the meta and para position of the benzene ring are described. Compounds (I) and (II) both crystallize with two molecules in the asymmetric unit, with generally similar conformations [r.m.s. overlay fits for (I) and (II) of 0.334 and 0.280 Å, respectively] that approximate to L-shapes. The thiophene rings in (I) are well ordered, whereas those in (II) exhibit `flip' rotational disorder [occupancies 0.662 (2) and 0.338 (2) for molecule 1, and 0.549 (3) and 0.451 (3) for molecule 2]. The packing for (I) features short C—H⋯O interactions arising from the C—H grouping adjacent to the cyanide group and C—H⋯N_c (c = cyanide) links arising from the methine groups to generate [110] double chains. Weak C—H⋯π interactions interlink the chains into a three-dimensional network. The packing for (II) features numerous C—H⋯O and C—H⋯π interactions arising from different donor groups to generate a three-dimensional network. Hirshfeld fingerprint plots indicate significant differences in the percentage contact surfaces for (I) and (II).

Keywords: crystal structure; carbohydrazide; methylation; weak hydrogen bonds.

CCDC references: 1578318; 1578317

1. Chemical context

Thiophene derivatives are important heterocyclic compounds widely used as building blocks in many agrochemicals and pharmaceuticals (Swanston, 2006 ). A valuable group of thiophenyl derivatives are the series of acylhydrazine derivatives, 2-[ArCH=N—NRCO(CH₂)_n-thiophene, where R = Me or H, and n = 0 or 1. Recent studies have investigated their anti-TB activities (Cardoso et al., 2014 ) and anti-cancer activities (Cardoso et al., 2017 ). We now report the crystal structures of two derivatives of the 2-[ArCH=N—NMeCOCH₂-thiophene series, bearing different substituents at the meta and para positions of the benzene ring, viz. (E)-N′-(3-cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, (I), and (E)-N′-(4-methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, (II). These complement our recent structural study (Cardoso et al., 2016a ) of isomeric ortho-, meta- and para-nitro derivatives in the same family.

2. Structural commentary

The molecular structure of (I) is shown in Fig. 1, which indicates the presence of two molecules, A (containing S1) and B (containing S2), in the asymmetric unit of the triclinic unit cell. The thiophene rings are well ordered [C11—S1—C14 = 92.14 (8); C26—S2—C29 = 92.39 (8)°]. For molecule A, the dihedral angle between the thiophene and benzene rings is 64.44 (5)°. The central CH=N—N(CH₃)—C(=O) fragment (C7/C8/C9/N1/N2/O1) in (I) is almost planar (r.m.s. deviation = 0.022 Å) and subtends dihedral angles of 2.28 (9) and 66.47 (5)° with the benzene and thiophene rings, respectively. The major twist in the molecule occurs about the C9—C10 bond [N2—C9—C10—C11 = −91.98 (16)°], giving the molecule an approximate overall L-shape. As seen for related compounds (Cardoso et al., 2016a), the N1—N2 bond length of 1.3797 (17) Å is significantly shortened compared to the reference value of ∼1.41 Å for an isolated N—N single bond and the C9—N2 amide bond of 1.3702 (19) Å is lengthened: these distance data can be interpreted in terms of significant delocalization of electrons over the methylidene–acetohydrazide fragment of the molecule. For molecule B, comparable geometrical data are as follows: C16–C21 benzene ring = A, C26–C29/S2 thiophene ring = B, C22/N4/N5/C23/C4/O2 linking chain (r.m.s. deviation = 0.033 Å) = C; dihedral angles A/B, A/C and B/C = 66.40 (8), 10.85 (9) and 58.33 (5)°, respectively; N5—C24—C25—C26 = −82.29 (18)°, N4—N5 = 1.3651 (17), C24—N5 = 1.3766 (19) Å. These data are generally similar to the corresponding values for molecule A and the r.m.s. overlay fit of molecules A and B of 0.334 Å and visual inspection (Fig. 2) confirms this.

Figure 1
The molecular structure of (I)

showing 50% displacement ellipsoids.

Figure 2
Overlay plot of molecules A (red) and B (black) for (I)

Compound (II) (Fig. 3) also crystallizes in space group P $[\overline{1}]$ with Z′ = 2 (molecule A containing S1 and molecule B containing S2). In this case, both thiophene ring show `flip' disorder over two conformations rotated by ∼180° in a 0.662 (2):0.338 (2) ratio about the C10—C11 bond for A and a 0.549 (3):0.451 (3) ratio about the C25—C26 bond for B. The major orientation for A has the S atom pointing towards the benzene ring. For B, the disorder is close to statistical, but there is a slight preference for the S atom to point away from the benzene ring. For molecule A, the dihedral angle between the thiophene and benzene rings is 79.38 (7)°. The central CH=N—N(CH₃)—C(=O) fragment (C7/C8/C9/N1/N2/O1) is almost planar (r.m.s. deviation = 0.013 Å) and the benzene and thiophene rings are twisted from it by 0.89 (12) and 78.80 (9)°, respectively. Thus, as for (I), the major twist in the molecule occurs about C9—C10 [N2—C9—C10—C11 = −86.1 (3)°], and an approximate overall L-shape results. Atom C15 of the methoxy group deviates slightly, by 0.068 (2) Å, from the plane of its attached ring. The N1—N2 [1.3780 (16) Å] and C9—N2 [1.3690 (18) Å] bond lengths show the same pattern as for (I), again indicating delocalization of electrons over the central grouping. Corresponding data for molecule B in (II) are as follows: C16–C21 benzene ring = A, C26–C29/S2 thiophene ring = B, C22/N3/N4/C23/C4/O3 linking chain (r.m.s. deviation = 0.021 Å) = C; dihedral angles A/B, A/C and B/C = 70.61 (8), 9.73 (17) and 77.66 (6)°, respectively; N4—C24—C25—C26 = 84.33 (17)°, N3—N4 = 1.3768 (17), C24—N4 = 1.375 (2) Å, displacement of C30 from the A ring = 0.155 (3) Å. Again, the two molecules have broadly similar conformations (Fig. 4) and the r.m.s. overlay fit is 0.280 Å.

Figure 3
The molecular structure of (II)

showing 50% displacement ellipsoids. Only the major orientation of the thiophene ring is shown.

Figure 4
Overlay plot of molecules A (red) and B (black) for (II)

. Only the major orientation of the thiophene ring is shown.

3. Supramolecular features

Given that there are no classical donor groups, the packing motifs for (I) and (II) are dominated by a variety of non-classical C—H⋯O, C—H⋯N and C—H⋯S, C—H⋯π and π-π- interactions (Tables 1 and 2).

Table 1
Hydrogen-bond geometry (Å, °) for (I)

Cg1, Cg2, Cg3 and Cg4 are the centroids of the C11–C14/S1, C1–C6, C26–C29/S2 and C16–C21 rings, respectively.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C4—H4⋯O1ⁱ	0.95	2.31	3.1691 (19)	151
C7—H7⋯N6ⁱⁱ	0.95	2.53	3.452 (2)	164
C19—H19⋯O2ⁱ	0.95	2.27	3.1980 (19)	164
C22—H22⋯N3ⁱⁱⁱ	0.95	2.61	3.536 (2)	164
C10—H10B⋯Cg4^iv	0.99	2.97	3.4724 (18)	113
C12—H12⋯Cg3	0.95	2.60	3.436 (2)	147
C23—H23C⋯Cg2^iv	0.98	2.90	3.5646 (19)	126
C25—H25B⋯Cg1^v	0.99	2.71	3.6910 (18)	169
Symmetry codes: (i) x+1, y+1, z; (ii) x, y-1, z-1; (iii) x-1, y, z+1; (iv) -x, -y+1, -z+1; (v) -x, -y, -z+1.

Table 2
Hydrogen-bond geometry (Å, °) for (II)

Cg1, Cg2, Cg3 and Cg4 are the centroids of the C11–C14/S1, C1–C6, C26–C29/S2 and C16–C21 rings, respectively.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C6—H6⋯S1ⁱ	0.95	2.87	3.7326 (14)	152
C10—H10B⋯O3	0.99	2.56	3.5366 (19)	169
C13—H13⋯O2ⁱⁱ	0.95	2.58	3.499 (2)	164
C15—H15A⋯O3ⁱⁱⁱ	0.98	2.50	3.478 (2)	176
C25—H25A⋯O1	0.99	2.38	3.3206 (19)	157
C28—H28⋯O4^iv	0.95	2.42	3.307 (2)	156
C29—H29⋯O1^v	0.95	2.50	3.422 (2)	163
C30—H30A⋯O1^vi	0.98	2.45	3.419 (2)	168
C6—H6⋯Cg1ⁱ	0.95	2.67	3.6071 (15)	169
C8—H8C⋯Cg2ⁱ	0.98	2.72	3.4831 (16)	135
C21—H21⋯Cg3^vii	0.95	2.90	3.6721 (18)	140
C23—H23A⋯Cg4^vii	0.98	2.81	3.6560 (16)	145
C23—H23C⋯Cg4^viii	0.98	2.88	3.6067 (16)	131
Symmetry codes: (i) -x+2, -y+1, -z; (ii) -x+2, -y+2, -z; (iii) -x+1, -y+2, -z; (iv) -x+1, -y, -z+1; (v) x-1, y, z; (vi) -x+2, -y, -z+1; (vii) -x+1, -y+1, -z+1; (viii) -x+2, -y+1, -z+1.

In (I), it is notable that both C—H groupings adjacent to the cyanide groups [i.e.:C4 (molecule A) and C19 (molecule B) in the 4-positions of the benzene rings] participate in short C—H⋯O interactions to generate separate [110] chains of A and B molecules, both of which feature C(10) chain motifs, with adjacent molecules in the chain related by translation symmetry. We may speculate that these C—H groupings have been `activated' (made more acidic) by being adjacent to the electron-withdrawing cyanide group (Pedireddi & Desiraju, 1992 ). The chains are cross-linked by C—H⋯N hydrogen bonds: in each case the donor is the methine group [i.e. C7 (molecule A) and C22 (molecule B)] and the acceptor is the cyanide-N atom of the other asymmetric molecule, i.e. A → B and B → A. This results in double chains (Fig. 5) propagating in [110] in which R₃³(18) loops are apparent. The chains are cross-linked by C—H⋯π interactions, with all the rings (i.e. both thiophene and both benzene rings) acting as acceptors. The shortest centroid–centroid separation between aromatic rings is 3.9895 (10) Å, indicating that any π–π stacking effects in (I) are very weak at best.

Figure 5
Fragment of a [110] hydrogen-bonded chain in the crystal of (I)

. Symmetry codes as in Table 1

; additionally (iv) x + 1, y, z − 1. All hydrogen atoms not involved in hydrogen bonds omitted for clarity.

The packing for (II) is less `tidy' in the sense that C—H entities belonging to several different groups (benzene ring, methylene group adjacent to the thiophene ring, thiophene ring, methoxy group) act as donors and none of the C—H⋯O links are particularly short. There are molecule A → molecule A, A → B, B → A and B → B links. Perhaps the most notable are a pair of bonds arising from the methylene groups that generate A + B dimers incorporating R₂²(8) loops, as shown in Fig. 3 above. A number of C—H⋯π interactions are observed, with all the rings acting as acceptors, but there are no aromatic π–π stacking interactions in (II) (shortest centroid–centroid separation > 4.9Å). When the different intermolecular interactions are taken together, a three-dimensional network arises in the crystal of (II).

4. Hirshfeld analysis

Hirshfeld surface fingerprint plots for (I) (Fig. 6) and (II) (Fig. 7) were calculated with CrystalExplorer17 (Turner et al., 2017 ). The plot for (I) has `wingtip' features that correspond to the short C—H⋯O hydrogen bonds described above, although the wingtips are not as pronounced as those seen for classical hydrogen bonds (compare: McKinnon et al., 2007 ). In (II), the wingtips are less apparent, presumably reflecting the longer (and weaker) C—H⋯O interactions in this structure, even though there are more of them in (II) than in (I).

Figure 6
Hirshfeld fingerprint plot for (I)

Figure 7
Hirshfeld fingerprint plot for (II)

When the fingerprint plots for (I) and (II) are decomposed into the separate types of contacts (McKinnon et al., 2007), some interesting differences arise (Table 3): H⋯H contacts represent the highest percentage in both structures, but they are far more significant in (II), representing over half the contact area, some 20% more than in (I). This deficit is largely made up by N⋯H/H⋯N contacts (i.e. the C—H⋯N hydrogen bonds) in (I), which are barely present in (II). The O⋯H/H⋯O contacts are slightly higher in (II) than (I), presumably reflecting that fact that there are many more C—H⋯O bonds in (II) (compare Table 2), although the H⋯O contacts are shorter in (I). The percentages of C⋯H/H⋯C contacts in the two compounds are very similar, whereas C⋯C contacts are insignificant in both structures, which presumably correlates with the very weak π–π stacking described above. Finally, S⋯H/H⋯S contacts are clearly more prominent in (I) although any C—H⋯S bonds in (I) would be regarded as very weak at best (shortest H⋯S separation = 2.95 Å). When the two molecules in the asymmetric unit of (I) are compared with each other (Table 3), there is little difference between them and the same applies to (II).

Table 3
Hirshfeld contact interactions (%)

Contact type	(I) A	(I) B	(I)	(II) A	(II) B	(II)
H⋯H	30.8	35.1	33.0	51.0	53.9	52.5
C⋯H/H⋯C	27.1	25.7	26.4	23.9	22.6	23.2
O⋯H/H⋯O	8.4	9.4	8.9	13.7	14.5	14.1
N⋯H/H⋯N	16.2	14.1	15.1	2.6	2.3	2.4
C⋯C	2.9	3.0	2.9	2.1	1.6	1.8
C⋯N/N⋯C	2.8	3.8	3.3	1.8	2.6	2.2
S⋯H/H⋯S	9.0	6.9	7.9	3.5	2.2	2.9
others	2.8	2.0	2.4	1.4	0.3	0.9

5. Database survey

A survey of the Cambridge Structural Database (Groom et al., 2016 ) updated to September 2017 for the common central –CH=N—N(CH₃)—C(=O)—CH₂– fragment of the title compounds revealed seven matches, viz. ALAHEC (Cardoso et al., 2016b ); FOTMUX (Ramírez et al., 2009a ); KULREP (Ramírez et al., 2009b ); OFEBIL (Cao et al., 2007 ), and EYUBAD, EYUBEH and EYUBIL: this latter trio of refcodes correspond to the three isomeric nitro compounds (Cardoso et al., 2016a) noted in the Chemical Context section above.

6. Synthesis and crystallization

The appropriate thienyl acetohydrazide derivative (Cardoso et al., 2014) (0.20 g, 1.0 equiv.) was suspended in acetone (5 ml) and potassium carbonate (4.0 equiv.) was added. The reaction mixture was stirred at room temperature for 30 minutes and methyl iodide (4.0 equiv.) was added. The reaction mixture was maintained at 313 K, until TLC indicated the reaction was complete. The mixture was then rotary evaporated to leave a residue, which was dissolved in water (20 ml) and extracted with ethyl acetate (3 × 10 ml). The organic fractions were combined, dried with anhydrous MgSO₄, filtered and the solvent evaporated at reduced pressure. The crystals used for the intensity data collections were recrystallized from methanol solution at room temperature to yield colourless plates of (I) and colourless slabs of (II).

(E)-N′-(3-Cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, (I). Yield: 78%; yellow solid; m.p. 690–692 K. ¹H NMR (400 MHz; DMSO) δ: 8.24 (1H; s; N=CH), 8.14 (1H; d; J_HH = 7.9 Hz; H-11′), 8.04 (1H; s; H-7′), 7.87 (1H; d; J_HH = 7.7 Hz; H-9′), 7.70–7.66 (1H; m; H-10′), 7.36 (1H; dd; J_HH = 5.1 and 1.2 Hz; H-5), 6.99–6.98 (1H; m; H-3), 6.96–6.94 (1H; m; H-4) 4.41 (2H; s; CH₂), 3.33 (3H; s; N-CH₃). ¹³C NMR (125 MHz; DMSO) δ: 170.9 (C=O), 138.5 (N=CH), 137.0 (C-2), 136.0 (C-6′ and C-9′), 132.8 (C-11′), 131.4 (C-7′), 130.4 (C-10′), 130.0 (C-3), 126.7 (C-4), 125.2 (C-5), 118.5 (CN), 111.9 (C-8′), 34.3 (N—CH₃), 28.1 (CH₂). MS/ESI: [M + Na]: 306. IR ν_max (cm⁻¹; KBr pellets): 1678 (C=O); 3101 (N—CH₃).

(E)-N′-(4-Methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, (II). Yield: 62%; yellow solid; m.p. 629–630 K. ¹H NMR (400 MHz; DMSO) δ: 7.94 (1H; s; N=CH), 7.76 (2H; d; J_HH = 8.6; H-7′ and H-11′), 7.34 (1H; d; J_HH = 4.8 Hz; H-5), 7.03 (2H; d; J_HH = 8.6 Hz; H-9′ and H-8′ and H-10′), 6.97–6.93 (2H; m; H-3 and H-4), 4.34 (2H; s; CH₂), 3.81 (3H; s; OCH₃) 3.33 (3H; s; N-CH₃). ¹³C NMR (125 MHz; DMSO) δ: 170.4 (C=O), 160.5 (C-9′), 140.4 (N=CH), 137.2 (C-2), 128.6 (C-7′ and C-11′), 127.3 (C-3), 126.5 (C-6′), 126.4 (C-4), 125.0 (C-5), 114.2 (C-8′ and C-10′), 55.2 (OCH₃), 34.3 (N—CH₃), 27.8 (CH₂). MS/ESI: [M + Na]: 299. IR ν_max (cm⁻¹; KBr pellet): 1668 (C=O); 2962 (N—CH₃).

7. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 4. The hydrogen atoms were geometrically placed (C—H = 0.95–1.00 Å) and refined as riding atoms. The constraint U_iso(H) = 1.2U_eq(carrier) or 1.5U_eq(methyl carrier) was applied in all cases. The N-methyl group was allowed to rotate, but not to tip, to best fit the electron density (AFIX 137 instruction): in every case this group rotated from its initial orientation to minimize steric interaction with H7; the final orientation leads to a rather short C8—H⋯O1 intramolecular contact but we do not regard this as a bond. The thiophene rings in both molecules of (II) show `flip' rotational disorder.

Table 4
Experimental details

	(I)	(II)
Crystal data
Chemical formula	C₁₅H₁₃N₃OS	C₁₅H₁₆N₂O₂S
M_r	283.34	288.36
Crystal system, space group	Triclinic, P $[\overline{1}]$	Triclinic, P $[\overline{1}]$
Temperature (K)	100	100
a, b, c (Å)	9.3594 (7), 10.1143 (7), 15.8070 (12)	7.2148 (5), 8.8307 (5), 24.1120 (17)
α, β, γ (°)	106.704 (5), 92.432 (7), 106.777 (5)	80.025 (6), 87.601 (7), 76.097 (6)
V (Å³)	1359.31 (18)	1468.67 (17)
Z	4	4
Radiation type	Mo Kα	Mo Kα
μ (mm⁻¹)	0.24	0.22
Crystal size (mm)	0.18 × 0.12 × 0.03	0.19 × 0.13 × 0.05

Data collection
Diffractometer	Rigaku Mercury CCD	Rigaku Mercury CCD
Absorption correction	Multi-scan (CrystalClear; Rigaku, 2012 )	Multi-scan (CrystalClear; Rigaku, 2012)
T_min, T_max	0.786, 1.000	0.820, 1.000
No. of measured, independent and observed [I > 2σ(I)] reflections	18105, 6217, 5204	19273, 6732, 5764
R_int	0.034	0.038
(sin θ/λ)_max (Å⁻¹)	0.650	0.649

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.038, 0.104, 1.04	0.044, 0.127, 1.06
No. of reflections	6217	6732
No. of parameters	363	367
H-atom treatment	H-atom parameters constrained	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.51, −0.32	0.63, −0.51
Computer programs: CrystalClear (Rigaku, 2012), SHELXS97 (Sheldrick, 2008 ), SHELXL2014 (Sheldrick, 2015 ), ORTEP-3 for Windows (Farrugia, 2012 ) and publCIF (Westrip, 2010 ).

Supporting information

CCDC references: 1578318; 1578317

Crystal structure: contains datablocks I, II, global. DOI: https://doi.org/10.1107/S2056989017014384/vm2205sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989017014384/vm2205Isup2.hkl

Structure factors: contains datablock II. DOI: https://doi.org/10.1107/S2056989017014384/vm2205IIsup3.hkl

checkCIF report

Computing details top

For both structures, data collection: CrystalClear (Rigaku, 2012); cell refinement: CrystalClear (Rigaku, 2012); data reduction: CrystalClear (Rigaku, 2012); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008). Program(s) used to refine structure: SHELXL2014/7 (Sheldrick, 2015) for (I); SHELXL2014 (Sheldrick, 2015) for (II). For both structures, molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); software used to prepare material for publication: publCIF (Westrip, 2010).

(E)-N'-(3-Cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide (I) top

Crystal data top

C₁₅H₁₃N₃OS	Z = 4
M_r = 283.34	F(000) = 592
Triclinic, P1	D_x = 1.385 Mg m⁻³
a = 9.3594 (7) Å	Mo Kα radiation, λ = 0.71075 Å
b = 10.1143 (7) Å	Cell parameters from 15155 reflections
c = 15.8070 (12) Å	θ = 2.2–27.5°
α = 106.704 (5)°	µ = 0.24 mm⁻¹
β = 92.432 (7)°	T = 100 K
γ = 106.777 (5)°	Plate, colourless
V = 1359.31 (18) Å³	0.18 × 0.12 × 0.03 mm

Data collection top

Rigaku Mercury CCD diffractometer	5204 reflections with I > 2σ(I)
ω scans	R_int = 0.034
Absorption correction: multi-scan (CrystalClear; Rigaku, 2012)	θ_max = 27.5°, θ_min = 2.6°
T_min = 0.786, T_max = 1.000	h = −11→12
18105 measured reflections	k = −12→13
6217 independent reflections	l = −20→20

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F² > 2σ(F²)] = 0.038	H-atom parameters constrained
wR(F²) = 0.104	w = 1/[σ²(F_o²) + (0.0527P)² + 0.4808P] where P = (F_o² + 2F_c²)/3
S = 1.04	(Δ/σ)_max = 0.001
6217 reflections	Δρ_max = 0.51 e Å⁻³
363 parameters	Δρ_min = −0.32 e Å⁻³
0 restraints

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
C1	0.44883 (17)	0.46449 (16)	0.16930 (10)	0.0182 (3)
C2	0.44634 (18)	0.57507 (16)	0.24628 (10)	0.0198 (3)
H2	0.3740	0.5550	0.2851	0.024*
C3	0.54885 (18)	0.71367 (16)	0.26619 (10)	0.0196 (3)
H3	0.5453	0.7879	0.3182	0.024*
C4	0.65642 (18)	0.74502 (16)	0.21093 (10)	0.0207 (3)
H4	0.7269	0.8397	0.2250	0.025*
C5	0.65933 (17)	0.63477 (16)	0.13419 (10)	0.0183 (3)
C6	0.55554 (17)	0.49516 (16)	0.11306 (10)	0.0180 (3)
H6	0.5579	0.4215	0.0604	0.022*
C7	0.34349 (17)	0.31634 (16)	0.14643 (10)	0.0187 (3)
H7	0.3492	0.2430	0.0946	0.022*
C8	0.15716 (19)	0.03219 (16)	0.09561 (10)	0.0227 (3)
H8A	0.1446	0.0603	0.0421	0.034*
H8B	0.0780	−0.0588	0.0904	0.034*
H8C	0.2560	0.0183	0.1018	0.034*
C9	0.04341 (17)	0.11622 (16)	0.23031 (10)	0.0202 (3)
C10	0.03819 (17)	0.24178 (16)	0.30984 (10)	0.0196 (3)
H10A	0.0702	0.3332	0.2944	0.024*
H10B	−0.0668	0.2255	0.3230	0.024*
C11	0.13786 (17)	0.25767 (15)	0.39154 (10)	0.0182 (3)
C12	0.09228 (19)	0.22118 (17)	0.46509 (10)	0.0228 (3)
H12	−0.0103	0.1799	0.4709	0.027*
C13	0.2143 (2)	0.25137 (18)	0.53227 (11)	0.0260 (3)
H13	0.2019	0.2329	0.5876	0.031*
C14	0.35045 (19)	0.30956 (17)	0.50833 (11)	0.0251 (3)
H14	0.4440	0.3371	0.5449	0.030*
C15	0.77123 (18)	0.66406 (16)	0.07614 (10)	0.0201 (3)
N1	0.24352 (14)	0.28688 (13)	0.19727 (8)	0.0185 (3)
N2	0.14646 (15)	0.14648 (13)	0.17394 (8)	0.0194 (3)
N3	0.86018 (16)	0.68439 (14)	0.02951 (9)	0.0244 (3)
O1	−0.04085 (14)	−0.00766 (12)	0.21693 (8)	0.0268 (3)
S1	0.33237 (4)	0.32713 (4)	0.40385 (3)	0.02304 (10)
C16	0.12951 (17)	0.59905 (16)	0.81831 (10)	0.0178 (3)
C17	0.19830 (17)	0.55084 (16)	0.74397 (10)	0.0193 (3)
H17	0.1600	0.4524	0.7071	0.023*
C18	0.32126 (17)	0.64447 (16)	0.72338 (10)	0.0199 (3)
H18	0.3666	0.6096	0.6726	0.024*
C19	0.37944 (18)	0.78915 (17)	0.77615 (10)	0.0212 (3)
H19	0.4638	0.8534	0.7617	0.025*
C20	0.31126 (18)	0.83843 (16)	0.85109 (10)	0.0204 (3)
C21	0.18679 (17)	0.74391 (16)	0.87227 (10)	0.0192 (3)
H21	0.1414	0.7782	0.9232	0.023*
C22	−0.00144 (17)	0.50111 (16)	0.84135 (10)	0.0183 (3)
H22	−0.0419	0.5329	0.8948	0.022*
C23	−0.23822 (18)	0.31465 (17)	0.89282 (10)	0.0212 (3)
H23A	−0.1578	0.3386	0.9417	0.032*
H23B	−0.3220	0.2317	0.8951	0.032*
H23C	−0.2736	0.3987	0.8988	0.032*
C24	−0.24432 (18)	0.14399 (16)	0.74387 (10)	0.0205 (3)
C25	−0.17210 (19)	0.11278 (16)	0.65922 (10)	0.0209 (3)
H25A	−0.0613	0.1532	0.6752	0.025*
H25B	−0.1977	0.0061	0.6323	0.025*
C26	−0.21947 (17)	0.17434 (16)	0.59025 (10)	0.0189 (3)
C27	−0.30906 (18)	0.09509 (18)	0.51024 (11)	0.0240 (3)
H27	−0.3551	−0.0073	0.4928	0.029*
C28	−0.32632 (19)	0.18168 (19)	0.45580 (11)	0.0270 (4)
H28	−0.3847	0.1437	0.3985	0.032*
C29	−0.24891 (19)	0.32583 (18)	0.49576 (11)	0.0248 (3)
H29	−0.2465	0.3998	0.4694	0.030*
C30	0.37254 (18)	0.98796 (17)	0.90659 (11)	0.0225 (3)
N4	−0.05999 (14)	0.37105 (13)	0.78716 (8)	0.0177 (3)
N5	−0.18037 (15)	0.27735 (13)	0.80764 (8)	0.0193 (3)
N6	0.42280 (17)	1.10717 (15)	0.95097 (9)	0.0275 (3)
O2	−0.35504 (14)	0.05496 (12)	0.75548 (8)	0.0281 (3)
S2	−0.15679 (5)	0.35686 (4)	0.59911 (3)	0.02189 (10)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.0199 (8)	0.0169 (7)	0.0193 (7)	0.0065 (6)	0.0007 (6)	0.0074 (6)
C2	0.0208 (8)	0.0197 (7)	0.0198 (7)	0.0069 (6)	0.0033 (6)	0.0069 (6)
C3	0.0223 (8)	0.0176 (7)	0.0174 (7)	0.0065 (6)	0.0021 (6)	0.0029 (6)
C4	0.0212 (8)	0.0175 (7)	0.0223 (8)	0.0042 (6)	0.0014 (6)	0.0068 (6)
C5	0.0192 (8)	0.0195 (7)	0.0179 (7)	0.0068 (6)	0.0022 (6)	0.0080 (6)
C6	0.0201 (8)	0.0179 (7)	0.0171 (7)	0.0080 (6)	0.0015 (6)	0.0055 (6)
C7	0.0207 (8)	0.0165 (7)	0.0175 (7)	0.0060 (6)	−0.0003 (6)	0.0035 (6)
C8	0.0276 (9)	0.0159 (7)	0.0195 (7)	0.0028 (6)	0.0031 (6)	0.0019 (6)
C9	0.0194 (8)	0.0189 (7)	0.0210 (7)	0.0044 (6)	0.0000 (6)	0.0062 (6)
C10	0.0176 (7)	0.0194 (7)	0.0223 (7)	0.0074 (6)	0.0038 (6)	0.0057 (6)
C11	0.0172 (7)	0.0143 (6)	0.0217 (7)	0.0062 (6)	0.0038 (6)	0.0019 (6)
C12	0.0210 (8)	0.0266 (8)	0.0213 (8)	0.0114 (6)	0.0076 (6)	0.0038 (6)
C13	0.0300 (9)	0.0307 (8)	0.0177 (7)	0.0149 (7)	0.0043 (6)	0.0028 (6)
C14	0.0246 (8)	0.0238 (8)	0.0235 (8)	0.0101 (6)	−0.0023 (6)	0.0007 (6)
C15	0.0220 (8)	0.0161 (7)	0.0205 (7)	0.0051 (6)	−0.0003 (6)	0.0046 (6)
N1	0.0191 (7)	0.0142 (6)	0.0205 (6)	0.0035 (5)	−0.0001 (5)	0.0049 (5)
N2	0.0218 (7)	0.0128 (6)	0.0191 (6)	0.0022 (5)	0.0020 (5)	0.0019 (5)
N3	0.0259 (7)	0.0223 (7)	0.0219 (7)	0.0049 (6)	0.0046 (6)	0.0048 (5)
O1	0.0274 (6)	0.0181 (5)	0.0268 (6)	−0.0018 (5)	0.0043 (5)	0.0038 (5)
S1	0.0175 (2)	0.02163 (19)	0.0281 (2)	0.00403 (15)	0.00253 (15)	0.00725 (16)
C16	0.0182 (7)	0.0169 (7)	0.0187 (7)	0.0056 (6)	−0.0002 (6)	0.0065 (6)
C17	0.0202 (8)	0.0169 (7)	0.0201 (7)	0.0059 (6)	0.0003 (6)	0.0052 (6)
C18	0.0206 (8)	0.0225 (7)	0.0174 (7)	0.0080 (6)	0.0033 (6)	0.0063 (6)
C19	0.0197 (8)	0.0216 (7)	0.0224 (8)	0.0042 (6)	0.0005 (6)	0.0095 (6)
C20	0.0226 (8)	0.0170 (7)	0.0201 (7)	0.0046 (6)	−0.0021 (6)	0.0060 (6)
C21	0.0206 (8)	0.0192 (7)	0.0183 (7)	0.0060 (6)	0.0012 (6)	0.0069 (6)
C22	0.0199 (8)	0.0185 (7)	0.0176 (7)	0.0073 (6)	0.0027 (6)	0.0057 (6)
C23	0.0241 (8)	0.0208 (7)	0.0185 (7)	0.0060 (6)	0.0050 (6)	0.0063 (6)
C24	0.0241 (8)	0.0163 (7)	0.0215 (7)	0.0064 (6)	0.0025 (6)	0.0066 (6)
C25	0.0264 (8)	0.0146 (7)	0.0208 (7)	0.0071 (6)	0.0045 (6)	0.0035 (6)
C26	0.0201 (8)	0.0174 (7)	0.0194 (7)	0.0071 (6)	0.0067 (6)	0.0044 (6)
C27	0.0212 (8)	0.0251 (8)	0.0221 (8)	0.0049 (6)	0.0039 (6)	0.0045 (6)
C28	0.0243 (9)	0.0352 (9)	0.0221 (8)	0.0121 (7)	0.0015 (6)	0.0072 (7)
C29	0.0288 (9)	0.0297 (8)	0.0211 (8)	0.0159 (7)	0.0060 (6)	0.0089 (6)
C30	0.0235 (8)	0.0210 (8)	0.0228 (8)	0.0041 (6)	0.0041 (6)	0.0093 (6)
N4	0.0178 (6)	0.0165 (6)	0.0198 (6)	0.0047 (5)	0.0031 (5)	0.0078 (5)
N5	0.0203 (7)	0.0168 (6)	0.0201 (6)	0.0041 (5)	0.0059 (5)	0.0063 (5)
N6	0.0310 (8)	0.0216 (7)	0.0260 (7)	0.0038 (6)	0.0058 (6)	0.0060 (6)
O2	0.0301 (7)	0.0188 (5)	0.0294 (6)	−0.0007 (5)	0.0063 (5)	0.0068 (5)
S2	0.0295 (2)	0.01730 (18)	0.01936 (19)	0.00892 (15)	0.00386 (15)	0.00484 (14)

Geometric parameters (Å, º) top

C1—C6	1.392 (2)	C16—C17	1.396 (2)
C1—C2	1.403 (2)	C16—C21	1.397 (2)
C1—C7	1.467 (2)	C16—C22	1.470 (2)
C2—C3	1.389 (2)	C17—C18	1.381 (2)
C2—H2	0.9500	C17—H17	0.9500
C3—C4	1.388 (2)	C18—C19	1.391 (2)
C3—H3	0.9500	C18—H18	0.9500
C4—C5	1.399 (2)	C19—C20	1.402 (2)
C4—H4	0.9500	C19—H19	0.9500
C5—C6	1.400 (2)	C20—C21	1.399 (2)
C5—C15	1.444 (2)	C20—C30	1.442 (2)
C6—H6	0.9500	C21—H21	0.9500
C7—N1	1.2848 (19)	C22—N4	1.2887 (19)
C7—H7	0.9500	C22—H22	0.9500
C8—N2	1.4607 (19)	C23—N5	1.4615 (19)
C8—H8A	0.9800	C23—H23A	0.9800
C8—H8B	0.9800	C23—H23B	0.9800
C8—H8C	0.9800	C23—H23C	0.9800
C9—O1	1.2246 (18)	C24—O2	1.2210 (19)
C9—N2	1.3702 (19)	C24—N5	1.3766 (19)
C9—C10	1.523 (2)	C24—C25	1.518 (2)
C10—C11	1.502 (2)	C25—C26	1.510 (2)
C10—H10A	0.9900	C25—H25A	0.9900
C10—H10B	0.9900	C25—H25B	0.9900
C11—C12	1.367 (2)	C26—C27	1.373 (2)
C11—S1	1.7316 (16)	C26—S2	1.7294 (15)
C12—C13	1.426 (2)	C27—C28	1.427 (2)
C12—H12	0.9500	C27—H27	0.9500
C13—C14	1.360 (2)	C28—C29	1.368 (2)
C13—H13	0.9500	C28—H28	0.9500
C14—S1	1.7175 (17)	C29—S2	1.7146 (17)
C14—H14	0.9500	C29—H29	0.9500
C15—N3	1.148 (2)	C30—N6	1.151 (2)
N1—N2	1.3797 (17)	N4—N5	1.3651 (17)

C6—C1—C2	119.22 (14)	C17—C16—C21	119.18 (14)
C6—C1—C7	118.67 (13)	C17—C16—C22	121.66 (14)
C2—C1—C7	122.10 (14)	C21—C16—C22	119.17 (13)
C3—C2—C1	120.46 (14)	C18—C17—C16	120.83 (14)
C3—C2—H2	119.8	C18—C17—H17	119.6
C1—C2—H2	119.8	C16—C17—H17	119.6
C4—C3—C2	120.75 (14)	C17—C18—C19	120.78 (14)
C4—C3—H3	119.6	C17—C18—H18	119.6
C2—C3—H3	119.6	C19—C18—H18	119.6
C3—C4—C5	118.88 (14)	C18—C19—C20	118.77 (14)
C3—C4—H4	120.6	C18—C19—H19	120.6
C5—C4—H4	120.6	C20—C19—H19	120.6
C4—C5—C6	120.80 (14)	C21—C20—C19	120.65 (14)
C4—C5—C15	119.99 (13)	C21—C20—C30	120.45 (14)
C6—C5—C15	119.21 (13)	C19—C20—C30	118.90 (14)
C1—C6—C5	119.88 (14)	C16—C21—C20	119.79 (14)
C1—C6—H6	120.1	C16—C21—H21	120.1
C5—C6—H6	120.1	C20—C21—H21	120.1
N1—C7—C1	119.32 (13)	N4—C22—C16	118.31 (13)
N1—C7—H7	120.3	N4—C22—H22	120.8
C1—C7—H7	120.3	C16—C22—H22	120.8
N2—C8—H8A	109.5	N5—C23—H23A	109.5
N2—C8—H8B	109.5	N5—C23—H23B	109.5
H8A—C8—H8B	109.5	H23A—C23—H23B	109.5
N2—C8—H8C	109.5	N5—C23—H23C	109.5
H8A—C8—H8C	109.5	H23A—C23—H23C	109.5
H8B—C8—H8C	109.5	H23B—C23—H23C	109.5
O1—C9—N2	120.86 (14)	O2—C24—N5	120.83 (14)
O1—C9—C10	121.55 (14)	O2—C24—C25	121.72 (14)
N2—C9—C10	117.60 (13)	N5—C24—C25	117.45 (13)
C11—C10—C9	112.24 (12)	C26—C25—C24	114.41 (13)
C11—C10—H10A	109.2	C26—C25—H25A	108.7
C9—C10—H10A	109.2	C24—C25—H25A	108.7
C11—C10—H10B	109.2	C26—C25—H25B	108.7
C9—C10—H10B	109.2	C24—C25—H25B	108.7
H10A—C10—H10B	107.9	H25A—C25—H25B	107.6
C12—C11—C10	126.61 (14)	C27—C26—C25	125.78 (14)
C12—C11—S1	110.52 (12)	C27—C26—S2	110.37 (12)
C10—C11—S1	122.87 (11)	C25—C26—S2	123.74 (11)
C11—C12—C13	113.18 (15)	C26—C27—C28	113.37 (15)
C11—C12—H12	123.4	C26—C27—H27	123.3
C13—C12—H12	123.4	C28—C27—H27	123.3
C14—C13—C12	112.47 (15)	C29—C28—C27	112.07 (15)
C14—C13—H13	123.8	C29—C28—H28	124.0
C12—C13—H13	123.8	C27—C28—H28	124.0
C13—C14—S1	111.68 (13)	C28—C29—S2	111.79 (12)
C13—C14—H14	124.2	C28—C29—H29	124.1
S1—C14—H14	124.2	S2—C29—H29	124.1
N3—C15—C5	178.57 (16)	N6—C30—C20	179.34 (19)
C7—N1—N2	117.84 (12)	C22—N4—N5	119.44 (13)
C9—N2—N1	116.96 (12)	N4—N5—C24	116.38 (12)
C9—N2—C8	120.85 (12)	N4—N5—C23	122.32 (12)
N1—N2—C8	122.11 (12)	C24—N5—C23	121.30 (13)
C14—S1—C11	92.14 (8)	C29—S2—C26	92.39 (8)

C6—C1—C2—C3	0.1 (2)	C21—C16—C17—C18	−0.2 (2)
C7—C1—C2—C3	179.36 (14)	C22—C16—C17—C18	−179.99 (14)
C1—C2—C3—C4	−0.6 (2)	C16—C17—C18—C19	−0.1 (2)
C2—C3—C4—C5	0.5 (2)	C17—C18—C19—C20	0.3 (2)
C3—C4—C5—C6	0.2 (2)	C18—C19—C20—C21	−0.2 (2)
C3—C4—C5—C15	−179.27 (14)	C18—C19—C20—C30	179.21 (14)
C2—C1—C6—C5	0.5 (2)	C17—C16—C21—C20	0.2 (2)
C7—C1—C6—C5	−178.73 (13)	C22—C16—C21—C20	−179.92 (14)
C4—C5—C6—C1	−0.7 (2)	C19—C20—C21—C16	−0.1 (2)
C15—C5—C6—C1	178.75 (13)	C30—C20—C21—C16	−179.44 (14)
C6—C1—C7—N1	−179.33 (14)	C17—C16—C22—N4	−5.5 (2)
C2—C1—C7—N1	1.4 (2)	C21—C16—C22—N4	174.70 (14)
O1—C9—C10—C11	87.85 (18)	O2—C24—C25—C26	97.62 (18)
N2—C9—C10—C11	−91.98 (16)	N5—C24—C25—C26	−82.29 (18)
C9—C10—C11—C12	−106.11 (17)	C24—C25—C26—C27	−109.77 (17)
C9—C10—C11—S1	73.77 (15)	C24—C25—C26—S2	74.51 (17)
C10—C11—C12—C13	−179.17 (14)	C25—C26—C27—C28	−175.81 (14)
S1—C11—C12—C13	0.93 (17)	S2—C26—C27—C28	0.39 (18)
C11—C12—C13—C14	−0.3 (2)	C26—C27—C28—C29	0.0 (2)
C12—C13—C14—S1	−0.46 (18)	C27—C28—C29—S2	−0.47 (18)
C1—C7—N1—N2	−179.87 (12)	C16—C22—N4—N5	179.09 (13)
O1—C9—N2—N1	−175.82 (14)	C22—N4—N5—C24	175.30 (13)
C10—C9—N2—N1	4.0 (2)	C22—N4—N5—C23	−5.4 (2)
O1—C9—N2—C8	0.9 (2)	O2—C24—N5—N4	−177.92 (14)
C10—C9—N2—C8	−179.28 (13)	C25—C24—N5—N4	2.0 (2)
C7—N1—N2—C9	178.23 (14)	O2—C24—N5—C23	2.7 (2)
C7—N1—N2—C8	1.6 (2)	C25—C24—N5—C23	−177.35 (13)
C13—C14—S1—C11	0.84 (13)	C28—C29—S2—C26	0.59 (13)
C12—C11—S1—C14	−1.01 (12)	C27—C26—S2—C29	−0.55 (12)
C10—C11—S1—C14	179.09 (12)	C25—C26—S2—C29	175.74 (13)

Hydrogen-bond geometry (Å, º) top

Cg1, Cg2, Cg3 and Cg4 are the centroids of the C11–C14/S1, C1–C6, C26–C29/S2 and C16–C21 rings, respectively.

D—H···A	D—H	H···A	D···A	D—H···A
C4—H4···O1ⁱ	0.95	2.31	3.1691 (19)	151
C7—H7···N6ⁱⁱ	0.95	2.53	3.452 (2)	164
C19—H19···O2ⁱ	0.95	2.27	3.1980 (19)	164
C22—H22···N3ⁱⁱⁱ	0.95	2.61	3.536 (2)	164
C10—H10B···Cg4^iv	0.99	2.97	3.4724 (18)	113
C12—H12···Cg3	0.95	2.60	3.436 (2)	147
C23—H23C···Cg2^iv	0.98	2.90	3.5646 (19)	126
C25—H25B···Cg1^v	0.99	2.71	3.6910 (18)	169

Symmetry codes: (i) x+1, y+1, z; (ii) x, y−1, z−1; (iii) x−1, y, z+1; (iv) −x, −y+1, −z+1; (v) −x, −y, −z+1.

(E)-N'-(4-Methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide (II) top

Crystal data top

C₁₅H₁₆N₂O₂S	Z = 4
M_r = 288.36	F(000) = 608
Triclinic, P1	D_x = 1.304 Mg m⁻³
a = 7.2148 (5) Å	Mo Kα radiation, λ = 0.71073 Å
b = 8.8307 (5) Å	Cell parameters from 16502 reflections
c = 24.1120 (17) Å	θ = 2.4–27.5°
α = 80.025 (6)°	µ = 0.22 mm⁻¹
β = 87.601 (7)°	T = 100 K
γ = 76.097 (6)°	Slab, colourless
V = 1468.67 (17) Å³	0.19 × 0.13 × 0.05 mm

Data collection top

Rigaku Mercury CCD diffractometer	5764 reflections with I > 2σ(I)
ω scans	R_int = 0.038
Absorption correction: multi-scan (CrystalClear; Rigaku, 2012)	θ_max = 27.5°, θ_min = 2.4°
T_min = 0.820, T_max = 1.000	h = −9→9
19273 measured reflections	k = −11→11
6732 independent reflections	l = −31→30

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F² > 2σ(F²)] = 0.044	H-atom parameters constrained
wR(F²) = 0.127	w = 1/[σ²(F_o²) + (0.0663P)² + 0.5738P] where P = (F_o² + 2F_c²)/3
S = 1.06	(Δ/σ)_max < 0.001
6732 reflections	Δρ_max = 0.63 e Å⁻³
367 parameters	Δρ_min = −0.51 e Å⁻³
0 restraints

Special details top

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq	Occ. (<1)
C1	0.67008 (18)	0.60106 (16)	−0.02475 (6)	0.0180 (3)
C2	0.5794 (2)	0.75469 (16)	−0.01600 (6)	0.0203 (3)
H2	0.5751	0.7804	0.0208	0.024*
C3	0.4965 (2)	0.86847 (16)	−0.06029 (6)	0.0218 (3)
H3	0.4357	0.9720	−0.0539	0.026*
C4	0.50131 (19)	0.83212 (16)	−0.11471 (6)	0.0200 (3)
C5	0.5850 (2)	0.67911 (16)	−0.12395 (6)	0.0203 (3)
H5	0.5857	0.6529	−0.1606	0.024*
C6	0.66768 (19)	0.56475 (16)	−0.07866 (6)	0.0194 (3)
H6	0.7235	0.4600	−0.0847	0.023*
C7	0.76607 (19)	0.48091 (16)	0.02163 (6)	0.0187 (3)
H7	0.8145	0.3742	0.0166	0.022*
C8	0.9558 (2)	0.24722 (16)	0.10720 (6)	0.0214 (3)
H8A	0.8552	0.1999	0.0968	0.032*
H8B	1.0132	0.1882	0.1430	0.032*
H8C	1.0541	0.2431	0.0778	0.032*
C9	0.8960 (2)	0.46599 (17)	0.16159 (6)	0.0214 (3)
C10	0.8168 (2)	0.64228 (17)	0.16296 (6)	0.0235 (3)
H10A	0.6984	0.6816	0.1403	0.028*
H10B	0.7852	0.6583	0.2022	0.028*
C11	0.9622 (2)	0.73367 (16)	0.13961 (6)	0.0208 (3)
C12	1.13089 (14)	0.74915 (10)	0.17678 (4)	0.0390 (3)	0.662 (2)
H12	1.1602	0.7098	0.2154	0.047*	0.662 (2)
S1A	1.13089 (14)	0.74915 (10)	0.17678 (4)	0.0390 (3)	0.338 (2)
C13	1.2333 (2)	0.84657 (19)	0.13194 (8)	0.0360 (4)
H13	1.3437	0.8787	0.1407	0.043*
C14	1.1583 (2)	0.88417 (18)	0.07941 (8)	0.0320 (4)
H14	1.2118	0.9443	0.0492	0.038*
C15	0.4195 (3)	0.9248 (2)	−0.21167 (7)	0.0349 (4)
H15A	0.3625	1.0230	−0.2370	0.052*
H15B	0.3453	0.8461	−0.2132	0.052*
H15C	0.5512	0.8841	−0.2234	0.052*
N1	0.78323 (16)	0.52285 (13)	0.06906 (5)	0.0181 (2)
N2	0.87351 (17)	0.41187 (13)	0.11301 (5)	0.0188 (2)
O1	0.98112 (17)	0.37640 (13)	0.20239 (4)	0.0287 (2)
O2	0.41861 (15)	0.95573 (12)	−0.15535 (4)	0.0257 (2)
S1	0.96968 (7)	0.81888 (6)	0.07181 (2)	0.02516 (17)	0.662 (2)
C12A	0.96968 (7)	0.81888 (6)	0.07181 (2)	0.02516 (17)	0.338 (2)
H12A	0.8915	0.8263	0.0402	0.030*	0.338 (2)
C16	0.7764 (2)	0.37271 (18)	0.53247 (6)	0.0232 (3)
C17	0.8223 (2)	0.21881 (18)	0.51957 (6)	0.0259 (3)
H17	0.8225	0.2045	0.4814	0.031*
C18	0.8670 (2)	0.08863 (18)	0.56149 (7)	0.0273 (3)
H18	0.8965	−0.0147	0.5522	0.033*
C19	0.8691 (2)	0.10806 (18)	0.61799 (6)	0.0246 (3)
C20	0.8182 (2)	0.25909 (19)	0.63179 (6)	0.0263 (3)
H20	0.8150	0.2731	0.6700	0.032*
C21	0.7718 (2)	0.38993 (18)	0.58890 (7)	0.0261 (3)
H21	0.7363	0.4931	0.5984	0.031*
C22	0.7391 (2)	0.51354 (18)	0.48843 (6)	0.0246 (3)
H22	0.6957	0.6158	0.4983	0.030*
C23	0.6759 (2)	0.79073 (19)	0.40919 (7)	0.0303 (3)
H23A	0.5514	0.8036	0.4280	0.045*
H23B	0.6659	0.8684	0.3744	0.045*
H23C	0.7702	0.8073	0.4342	0.045*
C24	0.7715 (2)	0.60876 (19)	0.34096 (7)	0.0273 (3)
C25	0.8229 (2)	0.43990 (19)	0.32963 (6)	0.0269 (3)
H25A	0.8984	0.4346	0.2945	0.032*
H25B	0.9018	0.3700	0.3609	0.032*
C26	0.6444 (2)	0.38433 (19)	0.32416 (7)	0.0270 (3)
C27	0.58683 (12)	0.23749 (10)	0.36718 (4)	0.0472 (3)	0.549 (3)
H27	0.6492	0.1698	0.3994	0.057*	0.549 (3)
S2A	0.58683 (12)	0.23749 (10)	0.36718 (4)	0.0472 (3)	0.451 (3)
C28	0.3942 (3)	0.2460 (3)	0.33734 (10)	0.0525 (6)
H28	0.3185	0.1725	0.3502	0.063*
C29	0.3408 (3)	0.3617 (3)	0.29275 (9)	0.0481 (5)
H29	0.2236	0.3762	0.2737	0.058*
C30	0.9352 (3)	−0.0128 (2)	0.71366 (7)	0.0395 (4)
H30A	0.9796	−0.1178	0.7365	0.059*
H30B	0.8089	0.0380	0.7268	0.059*
H30C	1.0253	0.0522	0.7172	0.059*
N3	0.76545 (17)	0.49815 (15)	0.43654 (5)	0.0236 (3)
N4	0.73577 (18)	0.63152 (15)	0.39574 (5)	0.0254 (3)
O3	0.7577 (2)	0.72180 (15)	0.30224 (5)	0.0378 (3)
O4	0.92322 (17)	−0.02841 (13)	0.65599 (5)	0.0317 (3)
S2	0.48492 (10)	0.47394 (10)	0.27350 (3)	0.0423 (3)	0.549 (3)
C27A	0.48492 (10)	0.47394 (10)	0.27350 (3)	0.0423 (3)	0.451 (3)
H27A	0.4809	0.5607	0.2438	0.051*	0.451 (3)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.0141 (6)	0.0180 (6)	0.0235 (7)	−0.0069 (5)	0.0000 (5)	−0.0033 (5)
C2	0.0184 (6)	0.0208 (6)	0.0234 (7)	−0.0052 (5)	−0.0003 (5)	−0.0073 (5)
C3	0.0185 (6)	0.0174 (6)	0.0298 (8)	−0.0027 (5)	−0.0019 (5)	−0.0061 (5)
C4	0.0149 (6)	0.0189 (6)	0.0262 (7)	−0.0057 (5)	−0.0022 (5)	−0.0006 (5)
C5	0.0189 (6)	0.0221 (7)	0.0215 (7)	−0.0071 (5)	0.0001 (5)	−0.0045 (5)
C6	0.0176 (6)	0.0170 (6)	0.0247 (7)	−0.0054 (5)	0.0012 (5)	−0.0046 (5)
C7	0.0171 (6)	0.0163 (6)	0.0239 (7)	−0.0064 (5)	0.0015 (5)	−0.0037 (5)
C8	0.0213 (7)	0.0157 (6)	0.0276 (7)	−0.0059 (5)	−0.0013 (5)	−0.0022 (5)
C9	0.0230 (7)	0.0221 (7)	0.0195 (7)	−0.0085 (5)	0.0030 (5)	−0.0013 (5)
C10	0.0276 (7)	0.0225 (7)	0.0210 (7)	−0.0068 (6)	0.0047 (5)	−0.0053 (5)
C11	0.0238 (7)	0.0161 (6)	0.0224 (7)	−0.0031 (5)	0.0001 (5)	−0.0047 (5)
C12	0.0445 (6)	0.0307 (5)	0.0468 (6)	−0.0145 (4)	0.0042 (4)	−0.0129 (4)
S1A	0.0445 (6)	0.0307 (5)	0.0468 (6)	−0.0145 (4)	0.0042 (4)	−0.0129 (4)
C13	0.0294 (8)	0.0229 (7)	0.0597 (12)	−0.0078 (6)	−0.0071 (8)	−0.0141 (7)
C14	0.0331 (8)	0.0169 (7)	0.0420 (9)	−0.0014 (6)	0.0092 (7)	−0.0026 (6)
C15	0.0456 (10)	0.0298 (8)	0.0263 (8)	−0.0068 (7)	−0.0088 (7)	0.0022 (6)
N1	0.0154 (5)	0.0176 (5)	0.0213 (6)	−0.0051 (4)	−0.0005 (4)	−0.0012 (4)
N2	0.0196 (6)	0.0159 (5)	0.0209 (6)	−0.0053 (4)	−0.0010 (4)	−0.0010 (4)
O1	0.0384 (6)	0.0264 (5)	0.0201 (5)	−0.0084 (5)	−0.0030 (4)	0.0015 (4)
O2	0.0263 (5)	0.0213 (5)	0.0265 (5)	−0.0029 (4)	−0.0059 (4)	0.0011 (4)
S1	0.0214 (3)	0.0195 (2)	0.0325 (3)	−0.00284 (18)	0.00245 (19)	−0.00200 (19)
C12A	0.0214 (3)	0.0195 (2)	0.0325 (3)	−0.00284 (18)	0.00245 (19)	−0.00200 (19)
C16	0.0202 (7)	0.0271 (7)	0.0231 (7)	−0.0073 (5)	−0.0001 (5)	−0.0036 (6)
C17	0.0260 (7)	0.0289 (7)	0.0232 (7)	−0.0057 (6)	0.0010 (6)	−0.0066 (6)
C18	0.0273 (8)	0.0247 (7)	0.0306 (8)	−0.0051 (6)	0.0006 (6)	−0.0079 (6)
C19	0.0205 (7)	0.0257 (7)	0.0269 (8)	−0.0072 (5)	−0.0023 (5)	0.0008 (6)
C20	0.0280 (8)	0.0305 (8)	0.0219 (7)	−0.0093 (6)	−0.0012 (6)	−0.0045 (6)
C21	0.0279 (8)	0.0238 (7)	0.0276 (8)	−0.0067 (6)	−0.0010 (6)	−0.0059 (6)
C22	0.0233 (7)	0.0249 (7)	0.0262 (7)	−0.0071 (6)	−0.0015 (6)	−0.0033 (6)
C23	0.0324 (8)	0.0263 (7)	0.0330 (8)	−0.0101 (6)	−0.0020 (6)	−0.0025 (6)
C24	0.0249 (7)	0.0348 (8)	0.0243 (7)	−0.0137 (6)	−0.0049 (6)	−0.0004 (6)
C25	0.0237 (7)	0.0349 (8)	0.0224 (7)	−0.0088 (6)	−0.0016 (6)	−0.0024 (6)
C26	0.0248 (7)	0.0327 (8)	0.0258 (7)	−0.0075 (6)	−0.0005 (6)	−0.0101 (6)
C27	0.0372 (5)	0.0359 (4)	0.0734 (7)	−0.0118 (3)	−0.0040 (4)	−0.0176 (4)
S2A	0.0372 (5)	0.0359 (4)	0.0734 (7)	−0.0118 (3)	−0.0040 (4)	−0.0176 (4)
C28	0.0597 (13)	0.0571 (13)	0.0596 (13)	−0.0358 (11)	0.0136 (11)	−0.0336 (11)
C29	0.0273 (9)	0.0755 (15)	0.0493 (12)	−0.0116 (9)	0.0014 (8)	−0.0334 (11)
C30	0.0535 (11)	0.0371 (9)	0.0285 (9)	−0.0192 (8)	−0.0129 (8)	0.0075 (7)
N3	0.0208 (6)	0.0265 (6)	0.0237 (6)	−0.0088 (5)	−0.0018 (5)	−0.0002 (5)
N4	0.0261 (6)	0.0255 (6)	0.0255 (6)	−0.0102 (5)	−0.0030 (5)	−0.0001 (5)
O3	0.0526 (8)	0.0360 (6)	0.0263 (6)	−0.0197 (6)	−0.0046 (5)	0.0047 (5)
O4	0.0369 (6)	0.0264 (6)	0.0304 (6)	−0.0091 (5)	−0.0075 (5)	0.0030 (4)
S2	0.0266 (4)	0.0548 (5)	0.0487 (5)	−0.0044 (3)	−0.0049 (3)	−0.0236 (3)
C27A	0.0266 (4)	0.0548 (5)	0.0487 (5)	−0.0044 (3)	−0.0049 (3)	−0.0236 (3)

Geometric parameters (Å, º) top

C1—C6	1.3935 (19)	C16—C21	1.393 (2)
C1—C2	1.4051 (18)	C16—C17	1.405 (2)
C1—C7	1.4686 (19)	C16—C22	1.467 (2)
C2—C3	1.379 (2)	C17—C18	1.376 (2)
C2—H2	0.9500	C17—H17	0.9500
C3—C4	1.401 (2)	C18—C19	1.403 (2)
C3—H3	0.9500	C18—H18	0.9500
C4—O2	1.3687 (17)	C19—O4	1.3659 (18)
C4—C5	1.3931 (19)	C19—C20	1.390 (2)
C5—C6	1.3970 (19)	C20—C21	1.395 (2)
C5—H5	0.9500	C20—H20	0.9500
C6—H6	0.9500	C21—H21	0.9500
C7—N1	1.2811 (18)	C22—N3	1.283 (2)
C7—H7	0.9500	C22—H22	0.9500
C8—N2	1.4611 (17)	C23—N4	1.457 (2)
C8—H8A	0.9800	C23—H23A	0.9800
C8—H8B	0.9800	C23—H23B	0.9800
C8—H8C	0.9800	C23—H23C	0.9800
C9—O1	1.2322 (18)	C24—O3	1.231 (2)
C9—N2	1.3690 (18)	C24—N4	1.375 (2)
C9—C10	1.5297 (19)	C24—C25	1.517 (2)
C10—C11	1.506 (2)	C25—C26	1.502 (2)
C10—H10A	0.9900	C25—H25A	0.9900
C10—H10B	0.9900	C25—H25B	0.9900
C11—S1A	1.5863 (17)	C26—S2A	1.6389 (19)
C11—C12	1.5863 (17)	C26—C27	1.6389 (19)
C11—C12A	1.6815 (15)	C26—C27A	1.6695 (17)
C11—S1	1.6815 (15)	C26—S2	1.6695 (17)
C12—C13	1.540 (2)	C27—C28	1.571 (2)
C12—H12	0.9500	C27—H27	0.9500
S1A—C13	1.540 (2)	S2A—C28	1.571 (2)
C13—C14	1.354 (3)	C28—C29	1.347 (3)
C13—H13	0.9500	C28—H28	0.9500
C14—C12A	1.6288 (19)	C29—C27A	1.605 (2)
C14—S1	1.6288 (19)	C29—S2	1.605 (2)
C14—H14	0.9500	C29—H29	0.9500
C15—O2	1.430 (2)	C30—O4	1.429 (2)
C15—H15A	0.9800	C30—H30A	0.9800
C15—H15B	0.9800	C30—H30B	0.9800
C15—H15C	0.9800	C30—H30C	0.9800
N1—N2	1.3780 (16)	N3—N4	1.3768 (17)
C12A—H12A	0.9500	C27A—H27A	0.9500

C6—C1—C2	118.52 (13)	C21—C16—C17	118.26 (14)
C6—C1—C7	120.41 (12)	C21—C16—C22	119.78 (14)
C2—C1—C7	121.07 (13)	C17—C16—C22	121.93 (14)
C3—C2—C1	120.60 (13)	C18—C17—C16	120.85 (14)
C3—C2—H2	119.7	C18—C17—H17	119.6
C1—C2—H2	119.7	C16—C17—H17	119.6
C2—C3—C4	120.31 (13)	C17—C18—C19	120.20 (14)
C2—C3—H3	119.8	C17—C18—H18	119.9
C4—C3—H3	119.8	C19—C18—H18	119.9
O2—C4—C5	125.10 (13)	O4—C19—C20	124.70 (14)
O2—C4—C3	114.90 (12)	O4—C19—C18	115.48 (14)
C5—C4—C3	119.99 (13)	C20—C19—C18	119.82 (14)
C4—C5—C6	119.10 (13)	C19—C20—C21	119.32 (14)
C4—C5—H5	120.5	C19—C20—H20	120.3
C6—C5—H5	120.5	C21—C20—H20	120.3
C1—C6—C5	121.40 (12)	C16—C21—C20	121.46 (14)
C1—C6—H6	119.3	C16—C21—H21	119.3
C5—C6—H6	119.3	C20—C21—H21	119.3
N1—C7—C1	118.66 (12)	N3—C22—C16	119.79 (14)
N1—C7—H7	120.7	N3—C22—H22	120.1
C1—C7—H7	120.7	C16—C22—H22	120.1
N2—C8—H8A	109.5	N4—C23—H23A	109.5
N2—C8—H8B	109.5	N4—C23—H23B	109.5
H8A—C8—H8B	109.5	H23A—C23—H23B	109.5
N2—C8—H8C	109.5	N4—C23—H23C	109.5
H8A—C8—H8C	109.5	H23A—C23—H23C	109.5
H8B—C8—H8C	109.5	H23B—C23—H23C	109.5
O1—C9—N2	121.10 (13)	O3—C24—N4	121.06 (15)
O1—C9—C10	121.10 (13)	O3—C24—C25	121.11 (14)
N2—C9—C10	117.78 (12)	N4—C24—C25	117.80 (13)
C11—C10—C9	110.00 (11)	C26—C25—C24	109.96 (13)
C11—C10—H10A	109.7	C26—C25—H25A	109.7
C9—C10—H10A	109.7	C24—C25—H25A	109.7
C11—C10—H10B	109.7	C26—C25—H25B	109.7
C9—C10—H10B	109.7	C24—C25—H25B	109.7
H10A—C10—H10B	108.2	H25A—C25—H25B	108.2
C10—C11—S1A	122.26 (11)	C25—C26—S2A	123.86 (12)
C10—C11—C12	122.26 (11)	C25—C26—C27	123.86 (12)
C10—C11—C12A	123.80 (11)	C25—C26—C27A	121.30 (12)
S1A—C11—C12A	113.85 (10)	S2A—C26—C27A	114.82 (10)
C10—C11—S1	123.80 (11)	C25—C26—S2	121.30 (12)
C12—C11—S1	113.85 (10)	C27—C26—S2	114.82 (10)
C13—C12—C11	99.52 (10)	C28—C27—C26	96.38 (12)
C13—C12—H12	130.2	C28—C27—H27	131.8
C11—C12—H12	130.2	C26—C27—H27	131.8
C13—S1A—C11	99.52 (10)	C28—S2A—C26	96.38 (12)
C14—C13—C12	116.71 (14)	C29—C28—C27	117.29 (17)
C14—C13—S1A	116.71 (14)	C29—C28—S2A	117.29 (17)
C14—C13—H13	121.6	C29—C28—H28	121.4
C12—C13—H13	121.6	C27—C28—H28	121.4
C13—C14—C12A	115.10 (14)	C28—C29—C27A	116.63 (16)
C13—C14—S1	115.10 (14)	C28—C29—S2	116.63 (16)
C13—C14—H14	122.4	C28—C29—H29	121.7
S1—C14—H14	122.4	S2—C29—H29	121.7
O2—C15—H15A	109.5	O4—C30—H30A	109.5
O2—C15—H15B	109.5	O4—C30—H30B	109.5
H15A—C15—H15B	109.5	H30A—C30—H30B	109.5
O2—C15—H15C	109.5	O4—C30—H30C	109.5
H15A—C15—H15C	109.5	H30A—C30—H30C	109.5
H15B—C15—H15C	109.5	H30B—C30—H30C	109.5
C7—N1—N2	119.49 (11)	C22—N3—N4	119.20 (13)
C9—N2—N1	116.55 (11)	C24—N4—N3	116.90 (13)
C9—N2—C8	120.98 (11)	C24—N4—C23	120.61 (13)
N1—N2—C8	122.28 (11)	N3—N4—C23	122.45 (13)
C4—O2—C15	117.14 (12)	C19—O4—C30	117.02 (13)
C14—S1—C11	94.79 (8)	C29—S2—C26	94.82 (11)
C14—C12A—C11	94.79 (8)	C29—C27A—C26	94.82 (11)
C14—C12A—H12A	132.6	C29—C27A—H27A	132.6
C11—C12A—H12A	132.6	C26—C27A—H27A	132.6

C6—C1—C2—C3	−2.5 (2)	C21—C16—C17—C18	−1.8 (2)
C7—C1—C2—C3	177.32 (13)	C22—C16—C17—C18	176.36 (15)
C1—C2—C3—C4	0.1 (2)	C16—C17—C18—C19	−0.6 (2)
C2—C3—C4—O2	−178.41 (13)	C17—C18—C19—O4	−177.30 (14)
C2—C3—C4—C5	2.0 (2)	C17—C18—C19—C20	2.7 (2)
O2—C4—C5—C6	178.77 (13)	O4—C19—C20—C21	177.79 (14)
C3—C4—C5—C6	−1.7 (2)	C18—C19—C20—C21	−2.2 (2)
C2—C1—C6—C5	2.8 (2)	C17—C16—C21—C20	2.3 (2)
C7—C1—C6—C5	−177.01 (12)	C22—C16—C21—C20	−175.90 (14)
C4—C5—C6—C1	−0.7 (2)	C19—C20—C21—C16	−0.3 (2)
C6—C1—C7—N1	172.62 (13)	C21—C16—C22—N3	171.72 (14)
C2—C1—C7—N1	−7.2 (2)	C17—C16—C22—N3	−6.4 (2)
O1—C9—C10—C11	92.19 (16)	O3—C24—C25—C26	−93.93 (18)
N2—C9—C10—C11	−86.14 (16)	N4—C24—C25—C26	84.33 (17)
C9—C10—C11—S1A	−82.95 (15)	C24—C25—C26—S2A	−116.66 (14)
C9—C10—C11—C12	−82.95 (15)	C24—C25—C26—C27	−116.66 (14)
C9—C10—C11—C12A	93.33 (14)	C24—C25—C26—C27A	61.63 (16)
C9—C10—C11—S1	93.33 (14)	C24—C25—C26—S2	61.63 (16)
C10—C11—C12—C13	178.21 (12)	C25—C26—C27—C28	−179.91 (14)
S1—C11—C12—C13	1.59 (11)	S2—C26—C27—C28	1.71 (13)
C10—C11—S1A—C13	178.21 (12)	C25—C26—S2A—C28	−179.91 (14)
C12A—C11—S1A—C13	1.59 (11)	C27A—C26—S2A—C28	1.71 (13)
C11—C12—C13—C14	−0.83 (16)	C26—C27—C28—C29	−2.45 (19)
C11—S1A—C13—C14	−0.83 (16)	C26—S2A—C28—C29	−2.45 (19)
S1A—C13—C14—C12A	−0.25 (19)	S2A—C28—C29—C27A	2.5 (2)
C12—C13—C14—S1	−0.25 (19)	C27—C28—C29—S2	2.5 (2)
C1—C7—N1—N2	−179.76 (11)	C16—C22—N3—N4	−177.97 (13)
O1—C9—N2—N1	−177.36 (13)	O3—C24—N4—N3	−176.37 (14)
C10—C9—N2—N1	0.97 (18)	C25—C24—N4—N3	5.4 (2)
O1—C9—N2—C8	−2.3 (2)	O3—C24—N4—C23	1.5 (2)
C10—C9—N2—C8	176.08 (12)	C25—C24—N4—C23	−176.75 (13)
C7—N1—N2—C9	176.67 (12)	C22—N3—N4—C24	178.08 (13)
C7—N1—N2—C8	1.63 (19)	C22—N3—N4—C23	0.2 (2)
C5—C4—O2—C15	−0.3 (2)	C20—C19—O4—C30	−2.7 (2)
C3—C4—O2—C15	−179.90 (13)	C18—C19—O4—C30	177.30 (15)
C13—C14—S1—C11	1.12 (13)	C28—C29—S2—C26	−1.01 (18)
C10—C11—S1—C14	−178.21 (12)	C25—C26—S2—C29	−179.06 (14)
C12—C11—S1—C14	−1.65 (10)	C27—C26—S2—C29	−0.63 (12)
C13—C14—C12A—C11	1.12 (13)	C28—C29—C27A—C26	−1.01 (18)
C10—C11—C12A—C14	−178.21 (12)	C25—C26—C27A—C29	−179.06 (14)
S1A—C11—C12A—C14	−1.65 (10)	S2A—C26—C27A—C29	−0.63 (12)

Hydrogen-bond geometry (Å, º) top

Cg1, Cg2, Cg3 and Cg4 are the centroids of the C11–C14/S1, C1–C6, C26–C29/S2 and C16–C21 rings, respectively.

D—H···A	D—H	H···A	D···A	D—H···A
C6—H6···S1ⁱ	0.95	2.87	3.7326 (14)	152
C10—H10B···O3	0.99	2.56	3.5366 (19)	169
C13—H13···O2ⁱⁱ	0.95	2.58	3.499 (2)	164
C15—H15A···O3ⁱⁱⁱ	0.98	2.50	3.478 (2)	176
C25—H25A···O1	0.99	2.38	3.3206 (19)	157
C28—H28···O4^iv	0.95	2.42	3.307 (2)	156
C29—H29···O1^v	0.95	2.50	3.422 (2)	163
C30—H30A···O1^vi	0.98	2.45	3.419 (2)	168
C6—H6···Cg1ⁱ	0.95	2.67	3.6071 (15)	169
C8—H8C···Cg2ⁱ	0.98	2.72	3.4831 (16)	135
C21—H21···Cg3^vii	0.95	2.90	3.6721 (18)	140
C23—H23A···Cg4^vii	0.98	2.81	3.6560 (16)	145
C23—H23C···Cg4^viii	0.98	2.88	3.6067 (16)	131

Symmetry codes: (i) −x+2, −y+1, −z; (ii) −x+2, −y+2, −z; (iii) −x+1, −y+2, −z; (iv) −x+1, −y, −z+1; (v) x−1, y, z; (vi) −x+2, −y, −z+1; (vii) −x+1, −y+1, −z+1; (viii) −x+2, −y+1, −z+1.

Hirshfeld contact interactions (%) top

Contact type	(I) A	(I) B	(I)	(II) A	(II) B	(II)
H···H	30.8	35.1	33.0	51.0	53.9	52.5
C···H/H···C	27.1	25.7	26.4	23.9	22.6	23.2
O···H/H···O	8.4	9.4	8.9	13.7	14.5	14.1
N···H/H···N	16.2	14.1	15.1	2.6	2.3	2.4
C···C	2.9	3.0	2.9	2.1	1.6	1.8
C···N/N···C	2.8	3.8	3.3	1.8	2.6	2.2
S···H/H···S	9.0	6.9	7.9	3.5	2.2	2.9
others	2.8	2.0	2.4	1.4	0.3	0.9

Acknowledgements

We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections.

References

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Volume 73| Part 11| November 2017| Pages 1636-1641

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research communications\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzyl­­idene-N-methyl-2-(thio­phen-2-yl)acetohydrazides

1. Chemical context

2. Structural commentary

3. Supra­molecular features

4. Hirshfeld analysis

5. Database survey

6. Synthesis and crystallization

7. Refinement

Supporting information

Acknowledgements

References

research communications

Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzylidene-N-methyl-2-(thiophen-2-yl)acetohydrazides

3. Supramolecular features