Crystal structure and Hirshfield surface analysis of 4-phenyl-3-(thio­phen-3-ylmeth­yl)-1H-1,2,4-triazole-5(4H)-thione

Vu Quoc, T.; Nguyen Ngoc, L.; Do Ba, D.; Pham Chien, T.; Nguyen Huy, H.; Van Meervelt, L.

doi:10.1107/S2056989018007193

research communications

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ISSN: 2056-9890

Volume 74| Part 6| June 2018| Pages 812-815

https://doi.org/10.1107/S2056989018007193

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Crystal structure and Hirshfield surface analysis of 4-phenyl-3-(thiophen-3-ylmethyl)-1H-1,2,4-triazole-5(4H)-thione

Trung Vu Quoc,^a Linh Nguyen Ngoc,^a Dai Do Ba,^a Thang Pham Chien,^b Hung Nguyen Huy ^b and Luc Van Meervelt ^c ^*

^aFaculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi, Vietnam, ^bDepartment of Chemistry, Hanoi University of Science, 19 Le Thanh Tong Street, Ha Ba Discrict, Hanoi, Vietnam, and ^cDepartment of Chemistry, KU Leuven, Biomolecular Architecture, Celestijnenlaan 200F, Leuven (Heverlee), B-3001, Belgium
^*Correspondence e-mail: luc.vanmeervelt@kuleuven.be

Edited by P. Bombicz, Hungarian Academy of Sciences, Hungary (Received 14 March 2018; accepted 14 May 2018; online 18 May 2018)

In the title compound, C₁₃H₁₁N₃S₂, the phenyl ring is twisted from the 1,2,4-triazole plane by 63.35 (9)° and by 47.35 (9)° from the thiophene plane. In the crystal, chains of molecules running along the c-axis direction are formed by N—H⋯S interactions [graph-set motif C(4)]. The 1,2,4-triazole and phenyl rings are involved in π–π stacking interactions [centroid–centroid distance = 3.4553 (10) Å]. The thiophene ring is involved in C—H⋯S and C—H⋯π interactions. The intermolecular interactions in the crystal packing were further analysed using Hirshfield surface analysis, which indicates that the most significant contacts are H⋯H (35.8%), followed by S⋯H/H⋯S (26.7%) and C⋯H/H⋯C (18.2%).

Keywords: crystal structure; thiophene; 1,2,4-triazole; thione tautomer; Hirshfield surfaces.

CCDC reference: 1843042

1. Chemical context

The triazole ring is an important component of bioactive heterocycles because of its effect in bactericides, pesticides and fungicides (Sengupta et al., 1978 ; Singh et al., 1979 ; Giri et al., 1978 ). Many derivatives containing 1,2,4-triazoline-5-thione show a variety of biological activities: anti-inflamatory (Sahin et al., 2001 ), antifungal (Knight et al., 1978 , 1979 ), analgesis (Mekuskiene et al., 1998 ) and bacteriostatic (Eweiss et al., 1986 ; Mazzone et al., 1981 ). Thiophene-containing 1,2,4-triazole derivatives have been studied and these compounds have shown promising antimycotic activity (Wujec et al., 2004 ). Combinations of the thiophene ring with other heterocyclic rings applied in conducting polymers have also been investigated (Ho et al., 2002 ; Mohamed et al., 2014 ; Bondarev et al., 2010 ).

As part of our studies, we have synthesized a new thiophene monomer containing 1,2,4-triazole-5-thione. The polymer obtained from 4-phenyl-3-(thiophen-3-yl-methyl)-1H-1,2,4-triazole-5(4H)-thione was further characterized by IR spectroscopy and TGA. TG–TGA analysis shows that the polymer is thermally stable above 473 K, showing degradation beyond 773 K and exothermic maxima at 745 K. We present here the synthesis and crystal structure of the title compound.

2. Structural commentary

The title compound crystallizes in the monoclinic space group P2₁/c with one molecule in the asymmetric unit (Fig. 1). In the crystalline state, the central 1,2,4-triazole ring exists in its thione tautomeric state with a C2=S1 distance of 1.6845 (16) Å. The short C4=N5 distance [1.302 (2) Å] indicates its double-bond character. The 1,2,4-triazole ring is almost planar (r.m.s. deviation = 0.002 Å for ring C2/N3/C4/N5/N6), with the substituents S1, C7 and C13 deviating by −0.020 (1), −0.028 (2) and 0.061 (2) Å, respectively. The plane of the 1,2,4-triazole ring forms dihedral angles of 79.70 (9) and 63.35 (9)° with the best planes through the thiophene and phenyl rings, respectively. The thiophene and phenyl rings are inclined to each other by 47.35 (9)°. The thiophene ring does not show rotational disorder as observed in previous structure determinations of similar compounds (Vu Quoc et al., 2017 ).

Figure 1
View of the asymmetric unit of the title compound, showing the atom-labelling scheme. Displacement ellipsoids are drawn at the 50% probability level. H atoms are shown as small circles of arbitrary radii.

3. Supramolecular features

The crystal packing of the title compound is shown in Fig. 2. The packing is dominated by N6—H6⋯S1 interactions (Table 1), resulting in the formation of chains of molecules with graph-set motif C(4) propagating along the c-axis direction. In addition, the 1,2,4-triazole and phenyl rings exhibit π–π stacking interactions [Cg2⋯Cg3ⁱ = 3.4553 (10) Å; angle of inclination = 9.98 (9)°; Cg2 and Cg3 are the centroids of the 1,2,4-triazole and phenyl rings, respectively; symmetry code: (i) x, −y + $[{3\over 2}]$ , z + $[{1\over 2}]$ ; Fig. 2].

Table 1
Hydrogen-bond geometry (Å, °)

Cg1 is the centroid of the C14/C15/S16/C17/C18 thiophene ring.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N6—H6⋯S1ⁱ	0.88	2.46	3.2866 (16)	156
C8—H8⋯S16ⁱⁱ	0.95	2.82	3.737 (2)	162
C10—H10⋯Cg1ⁱⁱⁱ	0.95	2.83	3.566 (2)	135
C13—H13B⋯Cg1^iv	0.99	2.76	3.409 (2)	123
Symmetry codes: (i) $[x, -y+{\script{3\over 2}}, z+{\script{1\over 2}}]$ ; (ii) x-1, y, z-1; (iii) x, y, z-1; (iv) -x+2, -y+1, -z+1.

Figure 2
Crystal packing of the title compound shown in projection down the a axis illustrating chain formation along the c-axis direction by N—H⋯S hydrogen bonding (yellow dashed lines) and the π–π stacking interactions between the 1,2,4-triazole (yellow) and phenyl (blue) rings.

The thiophene ring plays also a role in the crystal packing as illustrated by the weaker C8—H8⋯S16 interactions and C—H⋯π interactions involving H atoms H10 and H13B (Table 1, Fig. 3). The crystal packing contains no voids.

Figure 3
Partial crystal packing of the title compound, showing the C—H⋯π (gray dashed lines) and C—H⋯S interactions (yellow dashed lines) [see Table 1

; symmetry codes: (i) x, y, z + 1; (ii) −x + 2, −y + 1, −z + 1; (iii) x − 1, y, z − 1; (iv) x + 1, y, z + 1].

4. Hirshfield surface analysis

Hirshfield surface and two-dimensional fingerprint plot calculations were performed using CrystalExplorer (McKinnon et al., 2007 ; Spackman & Jayatilaka, 2009 ). The larger bright-red spots near atoms S1, N6, S16 and H8 (labelled 1, 2, 3 and 4) on the Hirshfield surface mapped over d_norm in Fig. 4a and b represent the N—H⋯S and C—H⋯S hydrogen bonds present in the crystal packing. The pale-red spots in Fig. 4a near atom N5 and the phenyl ring (labelled 5 and 6) are the result of the π–π stacking between the 1,2,4-triazole and phenyl rings. In Fig. 4b, an additional pale-red spot is present near atom S16 (labelled 7), indicating a short S⋯S contact [S16⋯S16ⁱ = 3.4688 (7) Å; symmetry code: (i) −x + 2, −y + 1, −z + 2]. The relative contributions of the different intermolecular interactions to the Hirshfield surface area, in descending order, are: H⋯H (35.8%), S⋯H/H⋯S (26.7%), C⋯H/H⋯C (18.2%), N⋯H/H⋯N (8.5%), C⋯N/N⋯C (3.7%), C⋯C (3.1%), S⋯C/C⋯S (2.8%) and S⋯S (1.2%). The latter value indicates that the S⋯S contact only makes a marginal contribution to the packing of the title compound.

Figure 4
Two views of the Hirshfield surface for the title compound mapped over d_norm in the range −0.386 to +1.111 a.u., showing (a) the N—H⋯S and C—H⋯S hydrogen bonding and π–π interactions between the 1,2,4-triazole and phenyl rings, and (b) the N—H⋯S and C—H⋯S hydrogen bonding and S⋯S interactions.

5. Database survey

A search of the Cambridge Structural Database (CSD, Version 5.39, last update November 2017; Groom et al., 2016 ) for crystal structures containing a 1H-1,2,4-triazole-5(4H)-thione moiety results in 287 (only organics) or 375 structures (including organometallics). When considering only organics, the average C=S and C=N distances are, respectively, 1.676 (9) Å [ranging from 1.608 to 1.699 Å] and 1.302 (11) Å [ranging from 1.275 to 1.410 Å]. For the 66 structures with atom N3 bearing a phenyl subsituent (only organics), the dihedral angle between the 1,2,4-triazole and phenyl rings varies from 55.3 to 90° (the latter when bulky substituents are present at position C4). In the case of a –CH₂R group at position C4, 53 structures are retrieved from the CSD. In this case, the torsion angle N=C—CH₂—R shows three favoured regions: (1) synperiplanar for small subsituents (torsion angles between −23 and +32°, 28 hits), (2) +anticlinal (torsion angles between 67 and 115°, 15 hits) and (3) −anticlinal (torsion angles between −87 and −140°, 10 hits).

6. Synthesis and crystallization

The reaction scheme used to synthesize the title compound, (3), is given in Fig. 5. Methyl 2-(thiophen-3-yl)acetate, (1), and 2-(thiophen-3-yl)acetohydrazide, (2), were synthesized as described in a previous study (Vu Quoc et al., 2017).

Figure 5
Reaction scheme for the title compound.

A mixture of hydrazide (2) (0.01 mol), phenylisothiocyanate (0.01 mol) and 20 mL ethanol was refluxed at 353 K for 8h. The solid precipitate was filtered, washed and recrystallized from ethanol to give white crystals (m.p. 416 K). Then, the mixture of the resulting solid (0.411 g), 10 mL ethanol and NaOH 10% (1.25 mmol) was refluxed at 353 K for 3 h. The reaction mixture was cooled and neutralized with HCl 10% to pH = 1–2. The product was filtered, washed and recrystallized from ethanol to give 1.42 g (yield 52%) of (3) in the form of pale-yellow crystals (m.p. 451 K). IR (Nicolet Impact 410 FTIR, KBr, cm⁻¹): 3453 (NH), 3088, 2911 (CH), 1576 (C=C thiophene), 1278, 1207 (C=S). ¹H NMR [Bruker XL-500, 500 MHz, d₆-DMSO, δ (ppm), J (Hz)]: 6.96 (m, 1H, H²), 6.75 (d, 1H, ⁵J = 4.5, H⁴), 7.38 (dd, 1H, ²J = 3.0, ⁴J = 5.0, H⁵), 3.85 (s, 2H, H⁶), 13.77 (s, 1H, H⁸), 7.26–7.28 (m, 2H, H¹¹ and H¹⁵), 7.48–7.50 (m, 3H, H¹², H¹³ and H¹⁴). ¹³C NMR [Bruker XL-500, 125 MHz, d₆-DMSO, δ (ppm)]: 123.86 (C2), 134.24 (C3), 128.02 (C4), 126.14 (C5), 26.35 (C6), 150.83 (C7), 167.85 (C9), 133.55 (C10), 128.16 (C11 and C15), 129.20 (C12 and C14), 129.34 (C13). Calculation for C₁₃H₁₁N₃S₂: M = 273 a.u.

7. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 2. The H atoms were placed at calculated positions and refined in riding mode, with a N—H distance of 0.88 Å or C—H distances of 0.95 (aromatic) and 0.99 Å (CH₂), and isotropic displacement parameters equal to 1.2U_eq of the parent atoms.

Table 2
Experimental details

Crystal data
Chemical formula	C₁₃H₁₁N₃S₂
M_r	273.37
Crystal system, space group	Monoclinic, P2₁/c
Temperature (K)	100
a, b, c (Å)	8.8257 (8), 16.0776 (16), 9.7437 (9)
β (°)	116.383 (3)
V (Å³)	1238.6 (2)
Z	4
Radiation type	Mo Kα
μ (mm⁻¹)	0.41
Crystal size (mm)	0.31 × 0.21 × 0.09

Data collection
Diffractometer	Bruker D8 Quest CMOS
Absorption correction	Multi-scan (SADABS; Bruker, 2014 )
T_min, T_max	0.700, 0.746
No. of measured, independent and observed [I > 2σ(I)] reflections	20908, 3082, 2697
R_int	0.038
(sin θ/λ)_max (Å⁻¹)	0.668

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.035, 0.097, 1.06
No. of reflections	3082
No. of parameters	163
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.59, −0.38
Computer programs: APEX2 (Bruker, 2014), SAINT (Bruker, 2013 ), SHELXT (Sheldrick, 2015a ), SHELXL (Sheldrick, 2015b ) and OLEX2 (Dolomanov et al., 2009 ).

Supporting information

CCDC reference: 1843042

Crystal structure: contains datablock I. DOI: https://doi.org/10.1107/S2056989018007193/zp2029sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989018007193/zp2029Isup2.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2056989018007193/zp2029Isup3.cml

checkCIF report

Computing details top

Data collection: APEX2 (Bruker, 2014); cell refinement: SAINT (Bruker, 2013); data reduction: SAINT (Bruker, 2013); program(s) used to solve structure: SHELXT (Sheldrick, 2015a); program(s) used to refine structure: SHELXL (Sheldrick, 2015b); molecular graphics: OLEX2 (Dolomanov et al., 2009); software used to prepare material for publication: OLEX2 (Dolomanov et al., 2009).

4-Phenyl-3-(thiophen-3-ylmethyl)-1H-1,2,4-triazole-5(4H)-thione top

Crystal data top

C₁₃H₁₁N₃S₂	F(000) = 568
M_r = 273.37	D_x = 1.466 Mg m⁻³
Monoclinic, P2₁/c	Mo Kα radiation, λ = 0.71073 Å
a = 8.8257 (8) Å	Cell parameters from 9914 reflections
b = 16.0776 (16) Å	θ = 2.9–28.3°
c = 9.7437 (9) Å	µ = 0.41 mm⁻¹
β = 116.383 (3)°	T = 100 K
V = 1238.6 (2) Å³	Block, yellow
Z = 4	0.31 × 0.21 × 0.09 mm

Data collection top

Bruker D8 Quest CMOS diffractometer	2697 reflections with I > 2σ(I)
φ and ω scans	R_int = 0.038
Absorption correction: multi-scan (SADABS; Bruker, 2014)	θ_max = 28.4°, θ_min = 2.9°
T_min = 0.700, T_max = 0.746	h = −11→11
20908 measured reflections	k = −21→21
3082 independent reflections	l = −12→12

Refinement top

Refinement on F²	Primary atom site location: dual
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F² > 2σ(F²)] = 0.035	H-atom parameters constrained
wR(F²) = 0.097	w = 1/[σ²(F_o²) + (0.0467P)² + 1.0177P] where P = (F_o² + 2F_c²)/3
S = 1.06	(Δ/σ)_max = 0.001
3082 reflections	Δρ_max = 0.59 e Å⁻³
163 parameters	Δρ_min = −0.38 e Å⁻³
0 restraints

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
S1	0.24329 (5)	0.74179 (3)	0.05131 (5)	0.01795 (11)
C2	0.40447 (19)	0.69570 (10)	0.19985 (17)	0.0138 (3)
N3	0.54765 (16)	0.65826 (8)	0.20563 (14)	0.0132 (3)
C4	0.64077 (19)	0.62860 (10)	0.35345 (17)	0.0141 (3)
N5	0.56488 (17)	0.64436 (8)	0.43857 (15)	0.0158 (3)
N6	0.42054 (16)	0.68568 (8)	0.34200 (15)	0.0151 (3)
H6	0.345269	0.703954	0.371018	0.018*
C7	0.59244 (19)	0.64996 (9)	0.08099 (17)	0.0130 (3)
C8	0.4894 (2)	0.60295 (10)	−0.04588 (18)	0.0184 (3)
H8	0.390920	0.576602	−0.050509	0.022*
C9	0.5328 (2)	0.59507 (11)	−0.16594 (19)	0.0235 (4)
H9	0.462216	0.563899	−0.254176	0.028*
C10	0.6780 (2)	0.63219 (11)	−0.1584 (2)	0.0225 (4)
H10	0.707029	0.626318	−0.240840	0.027*
C11	0.7808 (2)	0.67794 (11)	−0.02992 (19)	0.0201 (3)
H11	0.881215	0.702779	−0.023979	0.024*
C12	0.7379 (2)	0.68777 (10)	0.09068 (18)	0.0163 (3)
H12	0.807211	0.719883	0.178022	0.020*
C13	0.8089 (2)	0.58721 (11)	0.40650 (18)	0.0183 (3)
H13A	0.891635	0.627925	0.403638	0.022*
H13B	0.799421	0.541364	0.335289	0.022*
C14	0.87343 (19)	0.55283 (10)	0.56653 (18)	0.0154 (3)
C15	1.0020 (2)	0.58833 (10)	0.69147 (18)	0.0174 (3)
H15	1.058440	0.638022	0.687921	0.021*
S16	1.04926 (5)	0.53259 (3)	0.85492 (5)	0.02086 (12)
C17	0.89607 (19)	0.45897 (10)	0.76090 (17)	0.0150 (3)
H17	0.872539	0.412045	0.807510	0.018*
C18	0.8116 (2)	0.47912 (11)	0.60493 (19)	0.0196 (3)
H18	0.721852	0.446760	0.532024	0.024*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
S1	0.01244 (19)	0.0249 (2)	0.0173 (2)	0.00407 (14)	0.00726 (15)	0.00491 (15)
C2	0.0135 (7)	0.0139 (7)	0.0161 (7)	−0.0021 (5)	0.0084 (6)	−0.0012 (5)
N3	0.0134 (6)	0.0155 (6)	0.0117 (6)	0.0015 (5)	0.0066 (5)	0.0012 (5)
C4	0.0159 (7)	0.0148 (7)	0.0115 (7)	−0.0002 (5)	0.0061 (6)	0.0009 (5)
N5	0.0159 (6)	0.0175 (6)	0.0146 (6)	0.0017 (5)	0.0073 (5)	0.0016 (5)
N6	0.0147 (6)	0.0178 (6)	0.0154 (6)	0.0019 (5)	0.0091 (5)	0.0001 (5)
C7	0.0141 (7)	0.0147 (7)	0.0120 (6)	0.0038 (5)	0.0073 (5)	0.0024 (5)
C8	0.0163 (7)	0.0208 (8)	0.0164 (7)	0.0002 (6)	0.0058 (6)	−0.0006 (6)
C9	0.0274 (9)	0.0267 (9)	0.0145 (7)	0.0019 (7)	0.0075 (7)	−0.0030 (6)
C10	0.0284 (9)	0.0267 (9)	0.0176 (8)	0.0108 (7)	0.0150 (7)	0.0061 (7)
C11	0.0185 (7)	0.0235 (8)	0.0226 (8)	0.0049 (6)	0.0132 (7)	0.0083 (6)
C12	0.0154 (7)	0.0182 (8)	0.0151 (7)	0.0013 (6)	0.0067 (6)	0.0021 (6)
C13	0.0184 (7)	0.0238 (8)	0.0143 (7)	0.0070 (6)	0.0087 (6)	0.0053 (6)
C14	0.0157 (7)	0.0178 (7)	0.0137 (7)	0.0046 (6)	0.0073 (6)	0.0028 (6)
C15	0.0179 (7)	0.0183 (8)	0.0165 (7)	0.0007 (6)	0.0080 (6)	0.0023 (6)
S16	0.0193 (2)	0.0267 (2)	0.0146 (2)	−0.00099 (16)	0.00573 (16)	0.00087 (15)
C17	0.0129 (7)	0.0168 (7)	0.0132 (7)	−0.0010 (5)	0.0038 (6)	−0.0004 (5)
C18	0.0194 (8)	0.0213 (8)	0.0159 (7)	−0.0015 (6)	0.0058 (6)	0.0007 (6)

Geometric parameters (Å, º) top

S1—C2	1.6845 (16)	C10—C11	1.386 (3)
C2—N3	1.378 (2)	C11—H11	0.9500
C2—N6	1.338 (2)	C11—C12	1.395 (2)
N3—C4	1.3876 (19)	C12—H12	0.9500
N3—C7	1.4407 (19)	C13—H13A	0.9900
C4—N5	1.302 (2)	C13—H13B	0.9900
C4—C13	1.494 (2)	C13—C14	1.507 (2)
N5—N6	1.3727 (18)	C14—C15	1.367 (2)
N6—H6	0.8800	C14—C18	1.423 (2)
C7—C8	1.388 (2)	C15—H15	0.9500
C7—C12	1.385 (2)	C15—S16	1.7098 (16)
C8—H8	0.9500	S16—C17	1.7226 (16)
C8—C9	1.389 (2)	C17—H17	0.9500
C9—H9	0.9500	C17—C18	1.401 (2)
C9—C10	1.386 (3)	C18—H18	0.9500
C10—H10	0.9500

N3—C2—S1	129.51 (12)	C10—C11—H11	119.8
N6—C2—S1	127.09 (12)	C10—C11—C12	120.48 (16)
N6—C2—N3	103.39 (13)	C12—C11—H11	119.8
C2—N3—C4	107.58 (13)	C7—C12—C11	118.91 (15)
C2—N3—C7	126.59 (13)	C7—C12—H12	120.5
C4—N3—C7	125.83 (13)	C11—C12—H12	120.5
N3—C4—C13	123.47 (14)	C4—C13—H13A	109.1
N5—C4—N3	111.06 (14)	C4—C13—H13B	109.1
N5—C4—C13	125.43 (14)	C4—C13—C14	112.45 (13)
C4—N5—N6	103.95 (12)	H13A—C13—H13B	107.8
C2—N6—N5	114.02 (13)	C14—C13—H13A	109.1
C2—N6—H6	123.0	C14—C13—H13B	109.1
N5—N6—H6	123.0	C15—C14—C13	123.41 (15)
C8—C7—N3	118.99 (14)	C15—C14—C18	112.18 (14)
C12—C7—N3	119.67 (14)	C18—C14—C13	124.39 (15)
C12—C7—C8	121.33 (15)	C14—C15—H15	124.1
C7—C8—H8	120.6	C14—C15—S16	111.90 (12)
C7—C8—C9	118.88 (16)	S16—C15—H15	124.1
C9—C8—H8	120.6	C15—S16—C17	93.21 (8)
C8—C9—H9	119.6	S16—C17—H17	125.3
C10—C9—C8	120.70 (16)	C18—C17—S16	109.37 (12)
C10—C9—H9	119.6	C18—C17—H17	125.3
C9—C10—H10	120.2	C14—C18—H18	123.3
C9—C10—C11	119.68 (16)	C17—C18—C14	113.35 (14)
C11—C10—H10	120.2	C17—C18—H18	123.3

S1—C2—N3—C4	−179.20 (12)	N6—C2—N3—C4	−0.37 (16)
S1—C2—N3—C7	−0.1 (2)	N6—C2—N3—C7	178.76 (14)
S1—C2—N6—N5	178.97 (11)	C7—N3—C4—N5	−178.60 (14)
C2—N3—C4—N5	0.55 (18)	C7—N3—C4—C13	3.6 (2)
C2—N3—C4—C13	−177.23 (15)	C7—C8—C9—C10	1.1 (3)
C2—N3—C7—C8	−63.5 (2)	C8—C7—C12—C11	−0.1 (2)
C2—N3—C7—C12	117.40 (17)	C8—C9—C10—C11	−0.2 (3)
N3—C2—N6—N5	0.10 (17)	C9—C10—C11—C12	−0.9 (3)
N3—C4—N5—N6	−0.46 (17)	C10—C11—C12—C7	1.0 (2)
N3—C4—C13—C14	−173.79 (14)	C12—C7—C8—C9	−1.0 (2)
N3—C7—C8—C9	179.97 (15)	C13—C4—N5—N6	177.26 (15)
N3—C7—C12—C11	178.94 (14)	C13—C14—C15—S16	−178.12 (12)
C4—N3—C7—C8	115.47 (17)	C13—C14—C18—C17	178.09 (15)
C4—N3—C7—C12	−63.6 (2)	C14—C15—S16—C17	−0.21 (13)
C4—N5—N6—C2	0.22 (18)	C15—C14—C18—C17	−0.4 (2)
C4—C13—C14—C15	−106.27 (18)	C15—S16—C17—C18	−0.01 (13)
C4—C13—C14—C18	75.4 (2)	S16—C17—C18—C14	0.22 (18)
N5—C4—C13—C14	8.8 (2)	C18—C14—C15—S16	0.37 (18)

Hydrogen-bond geometry (Å, º) top

Cg1 is the centroid of the C14/C15/S16/C17/C18 thiophene ring.

D—H···A	D—H	H···A	D···A	D—H···A
N6—H6···S1ⁱ	0.88	2.46	3.2866 (16)	156
C8—H8···S16ⁱⁱ	0.95	2.82	3.737 (2)	162
C10—H10···Cg1ⁱⁱⁱ	0.95	2.83	3.566 (2)	135
C13—H13B···Cg1^iv	0.99	2.76	3.409 (2)	123

Symmetry codes: (i) x, −y+3/2, z+1/2; (ii) x−1, y, z−1; (iii) x, y, z−1; (iv) −x+2, −y+1, −z+1.

Funding information

LVM thanks VLIR-UOS (project ZEIN2014Z182) for financial support.

References

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Volume 74| Part 6| June 2018| Pages 812-815

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research communications\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Crystal structure and Hirshfield surface analysis of 4-phenyl-3-(thio­phen-3-ylmeth­yl)-1H-1,2,4-triazole-5(4H)-thione

1. Chemical context

2. Structural commentary

3. Supra­molecular features

4. Hirshfield surface analysis

5. Database survey

6. Synthesis and crystallization

7. Refinement

Supporting information

Funding information

References

research communications

Crystal structure and Hirshfield surface analysis of 4-phenyl-3-(thiophen-3-ylmethyl)-1H-1,2,4-triazole-5(4H)-thione

3. Supramolecular features