Crystal structure and Hirshfeld surface analysis of a new benzodiazepine derivative: 4-di­chloro­methyl-2,3-di­hydro-1H-1,5-benzodiazepin-2-one

Chkirate, K.; Kansiz, S.; Karrouchi, K.; Mague, J.T.; Dege, N.; Essassi, E.M.

doi:10.1107/S205698901801681X

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Volume 75| Part 1| January 2019| Pages 33-37

https://doi.org/10.1107/S205698901801681X

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Crystal structure and Hirshfeld surface analysis of a new benzodiazepine derivative: 4-dichloromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Karim Chkirate,^a ^* Sevgi Kansiz,^b Khalid Karrouchi,^c Joel T. Mague,^d Necmi Dege ^b and El Mokhtar Essassi ^a

^aLaboratory of Heterocyclic Organic Chemistry URAC 21, Pole of Competence Pharmacochemistry, Av Ibn Battouta, BP 1014, Faculty of Sciences, Mohammed V University, Rabat, Morocco, ^bOndokuz Mayıs University, Faculty of Arts and Sciences, Department of Physics, 55139, Kurupelit, Samsun, Turkey, ^cPhysicochemical Service, Drugs Quality Control Laboratory, Division of Drugs and Pharmacy, Ministry of Health, 10100 Rabat, Morocco, and ^dDepartment of Chemistry, Tulane University, New Orleans, LA 70118, USA
^*Correspondence e-mail: chkirate.karim1@gmail.com

Edited by D.-J. Xu, Zhejiang University (Yuquan Campus), China (Received 18 November 2018; accepted 26 November 2018; online 1 January 2019)

In the title compound, C₁₀H₈Cl₂N₂O, the seven-membered diazepine ring adopts a boat-shaped conformation. The mean planes of the two rings of the benzodiazepine unit are inclined to each other by 22.05 (6)°. In the crystal, molecules are linked by pairs of N—H⋯O hydrogen bonds, forming inversion dimers with an R²₂(8) ring motif. The dimers are linked by C—H⋯π interactions, forming layers lying parallel to (10 $[\overline{1}]$ ). The roles of the intermolecular interactions in the crystal packing were clarified using Hirshfeld surface analysis; the most important contributions are from Cl⋯H/H⋯Cl (30.5%) and H⋯H (22.5%) interactions.

Keywords: crystal structure; benzodiazepin-2-one; phase-transfer catalysis; hydrogen bonding; C—H⋯π(ring) interaction; Hirshfeld surface analysis.

CCDC reference: 1881324

1. Chemical context

Interest in benzodiazepines and their derivatives has concentrated on their pharmacological (Beaulieu, 2006 ; Tosti et al., 2007 ) and chemical (Ahabchane & Essassi, 2000 ) properties. In addition, they are used as raw materials for the synthesis of substances with antibacterial (Essassi et al., 1991 ) and antitumor (Lee et al., 1978 ) activities. They are also used as secondary analgesics or as co-analgesics (Aveline et al., 2001 ; Muster & Ben Slama, 2004 ). 1,5-Benzodiazepine derivatives have been shown to exhibit anti-inflammatory (Roma et al., 1991 ), hypnotics (Kudo, 1982 ), anti-HIV-1 (Di Braccio et al., 2001 ), anticonvulsant (De Sarro et al., 1996 ), antimicrobial (Kumar & Joshi, 2007 ) and antitumor (Kamal et al., 2008 ) activities. In a continuation of our work on the synthesis of 1,5-benzodiazepine derivatives (Chkirate et al., 2018 ), we report herein on the synthesis and crystal structure of the title compound, 4-dichloromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one, together with the Hirshfeld surface analysis.

2. Structural commentary

The molecular structure of the title compound is illustrated in Fig. 1. The seven-membered diazepine ring (C1/C6/N1/C7–C9/N2) adopts a boat-shaped conformation: puckering parameters are Q(2) = 0.7692 (14) Å, φ(2) = 21.25 (10)°, Q(3) = 0.2131 (14) Å, φ(3) = 131.2 (4)°, with a total puckering amplitude Q of 0.7982 (14) Å. The mean planes of the two rings are inclined to each other by 22.05 (6)°. The C9=N2 bond has a Z configuration and a bond length of 1.2737 (18) Å. The C1—N2 [1.4124 (17) Å] and C6—N1 [1.4068 (18) Å] bond lengths are typical for a 2,3-dihydro-1H-1,5-benzodiazepin-2-one ring system and similar to those observed for the structure of a very similar compound, 4-methyl-2,3-dihydro-1H-15-benzodiazepin-2-one monohydrate (Saber et al., 2010 ); see also the Database survey section below.

Figure 1
The molecular structure of the title compound, with the atom labelling. Displacement ellipsoids are drawn at the 50% probability level.

3. Supramolecular features

In the crystal, molecules are linked by pairs of N—H⋯O hydrogen bonds, forming inversion dimers with an $[R_{2}^{2}]$ (8) ring motif (Table 1 and Fig. 2). The dimers are linked by C—H⋯π interactions, forming layers that lie parallel to the (10 $[\overline{1}]$ ) plane (Fig. 3 and Table 1). There are no other significant intermolecular interactions present. The H⋯H or H⋯Cl intermolecular distances all exceed the sum of their van der Waals radii.

Table 1
Hydrogen-bond geometry (Å, °)

Cg1 is the centroid of the C1–C6 benzene ring.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1⋯O1ⁱ	0.86 (2)	2.15 (2)	2.977 (2)	160 (2)
C3—H3⋯Cg1ⁱⁱ	0.95 (2)	2.66 (2)	3.450 (2)	142 (1)
Symmetry codes: (i) -x+1, -y, -z+1; (ii) $[-x+{\script{1\over 2}}, y+{\script{1\over 2}}, -z+{\script{1\over 2}}]$ .

Figure 2
A partial view along the b-axis of the crystal packing of the title compound. The N—H⋯O hydrogen bonds are shown as blue dashed lines and the C—H⋯π(ring) interactions as purple dashed lines (see Table 1

; H atoms not involved in these interactions have been omitted).

Figure 3
A view normal to (10 $[\overline{1}]$ ) of the crystal packing of the title compound. The N—H⋯O hydrogen bonds are shown as dashed lines and the C—H⋯π interactions as blue arrows (see Table 1

; H atoms not involved in these interactions have been omitted).

4. Database survey

A search of the Cambridge Structural Database (CSD, version 5.39, update August 2018; Groom et al., 2016 ) for the 2,3-dihydro-1H-1,5-benzodiazepin-2-one skeleton yielded 12 hits (see supporting information). In all 12 compounds, the diazopine ring has a boat-shaped conformation, as does the title compound. The benzene ring and the mean plane of the diazepine ring are inclined to each other by dihedral angles ranging from ca 19.95 to 29.16°, compared to 22.05 (6)° in the title compound. The C=O bond lengths vary from ca 1.217–1.241 Å and the C=N bond lengths vary from ca 1.272–1.295 Å. In the title compound, the corresponding bond lengths are 1.2288 (18) and 1.2737 (18) Å, respectively. The C_aromatic—N bond lengths in the diazepine ring range from ca 1.391 to 1.415 Å, compared to values of 1.4124 (17) and 1.4068 (18) Å for bonds C1—N2 and C6—N1, respectively, in the title compound. Hence, the various geometrical parameters mentioned above for the title compound are typical for 2,3-dihydro-1H-1,5-benzodiazepin-2-ones. In the crystals of all but one compound, molecules are linked by pairs of N—H⋯O hydrogen bonds, forming inversion dimers with an $[R_{2}^{2}]$ (8) ring motif. The same arrangement is observed in the crystal of the title compound.

5. Hirshfeld surface analysis

The molecular Hirshfeld surfaces were generated using a standard (high) surface resolution with the three-dimensional d_norm surfaces mapped over a fixed colour scale of −0.456 (red) to 1.092 (blue) Å using the CrystalExplorer program (Turner et al., 2017 ). The red spots on the surface indicate the intermolecular contacts involved in the hydrogen bonds. In Figs. 4 and 5, the red spots are attributed to the H⋯O close contacts.

Figure 4
The Hirshfeld surfaces of the title compound mapped over d_norm, d_i and d_e.

Figure 5
Hirshfeld surface mapped over d_norm to visualize the intermolecular interactions.

Fig. 6 shows the two-dimensional fingerprint plot for the sum of the contacts contributing to the Hirshfeld surface represented in normal mode. The graph shown in Fig. 7 represents the O⋯H/H⋯O contacts (30.4%) between the oxygen atoms inside the surface and the hydrogen atoms outside the surface at d_e + d_i = 2.5 Å and two symmetrical points at the top, bottom left and right. These data are characteristic of C—H⋯O hydrogen bonding.

Figure 6
The overall fingerprint plot for the title compound.

Figure 7
Two-dimensional fingerprint plots with a d_norm view of the Cl⋯H/H⋯Cl (30.5%), H⋯H (22.5%), C⋯H/H⋯C (15%) and O⋯H/H⋯O (5.5%) contacts in the title compound.

The H⋯H graph in Fig. 7 shows the two-dimensional fingerprint of the (d_i, d_e) points associated with hydrogen atoms. It is characterized by an end point that points to the origin and corresponds to d_i = d_e = 1.08 Å, which indicates the presence of the H⋯H contacts in this study, which make a contribution of 54.3% to the crystal packing. The C⋯H/H⋯C graph in Fig. 7 shows the contacts between carbon atoms inside the Hirshfeld surface and hydrogen atoms outside and vice versa and has two symmetrical wings on the left and right sides (6.8%). Much weaker C⋯C (5.5%), O⋯N/N⋯O (2.4%), O⋯O (0.3%) and S⋯H/H⋯S (0.2%) contacts also occur.

A view of the three-dimensional Hirshfeld surface of the title compound plotted over electrostatic potential energy in the range −0.082 to 0.042 a.u. using the STO-3G basis set at the Hartree–Fock level of theory is shown in Fig. 8 where the N—H⋯O and C—H⋯π hydrogen-bond donors and acceptors are shown as blue and red areas around the atoms related with positive (hydrogen-bond donors) and negative (hydrogen-bond acceptors) electrostatic potentials, respectively.

Figure 8
A view of the three-dimensional Hirshfeld surface plotted over electrostatic potential energy

6. Synthesis and crystallization

The title compound was synthesized by the reaction of dichloromethane with (Z)-4-(2-oxopropylidene)-4,5-dihydro-1H-benzo [b][1,5]-diazepine-2(3H)-one under phase-transfer catalysis (PTC) conditions using tetra-n-bromide butylammonium (TBAB) as catalyst and potassium carbonate as base.

To a solution of 4-(2-oxopropylidene)-4,5-dihydro-1H-benzo-[b][1,5]diazepine-2(3H)-one (2.87 mmol) in dichloromethane (30 ml) as reagent and solvent, potassium carbonate (5.71 mmol) and a catalytic amount of tetra-n-butylammonium bromide (0.37 mmol) were added. The mixture was stirred for 48 h. The solid material was removed by filtration and the solvent evaporated under vacuum. The residue was purified through silica gel column chromatography using hexane/ethyl acetate (ratio 8:2). Slow evaporation at room temperature lead to the formation of colourless single crystals (yield 69%).

7. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 2. All H atoms were located in a difference-Fourier map and freely refined.

Table 2
Experimental details

Crystal data
Chemical formula	C₁₀H₈Cl₂N₂O
M_r	243.08
Crystal system, space group	Monoclinic, P2₁/n
Temperature (K)	150
a, b, c (Å)	12.1783 (6), 5.7217 (3), 14.8258 (7)
β (°)	95.740 (1)
V (Å³)	1027.89 (9)
Z	4
Radiation type	Cu Kα
μ (mm⁻¹)	5.46
Crystal size (mm)	0.33 × 0.24 × 0.14

Data collection
Diffractometer	Bruker D8 VENTURE PHOTON 100 CMOS
Absorption correction	Multi-scan (SADABS; Krause et al., 2015 )
T_min, T_max	0.36, 0.51
No. of measured, independent and observed [I > 2σ(I)] reflections	7403, 2051, 2020
R_int	0.028
(sin θ/λ)_max (Å⁻¹)	0.625

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.028, 0.074, 1.05
No. of reflections	2051
No. of parameters	169
H-atom treatment	All H-atom parameters refined
Δρ_max, Δρ_min (e Å⁻³)	0.32, −0.31
Computer programs: APEX3 and SAINT (Bruker, 2016 ), SHELXT (Sheldrick, 2015a ), SHELXL2018 (Sheldrick, 2015b ), DIAMOND (Brandenburg & Putz, 2012 ), Mercury (Macrae et al., 2008 ) and SHELXTL (Sheldrick, 2008 ).

Supporting information

CCDC reference: 1881324

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S205698901801681X/xu5953sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S205698901801681X/xu5953Isup2.hkl

Supporting information file. DOI: https://doi.org/10.1107/S205698901801681X/xu5953Isup4.cml

CSD search results. DOI: https://doi.org/10.1107/S205698901801681X/xu5953sup3.pdf

checkCIF report

Computing details top

Data collection: APEX3 (Bruker, 2016); cell refinement: SAINT (Bruker, 2016); data reduction: SAINT (Bruker, 2016); program(s) used to solve structure: SHELXT (Sheldrick, 2015a); program(s) used to refine structure: SHELXL2018 (Sheldrick, 2015b); molecular graphics: DIAMOND (Brandenburg & Putz, 2012) and Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

4-Dichloromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one top

Crystal data top

C₁₀H₈Cl₂N₂O	F(000) = 496
M_r = 243.08	D_x = 1.571 Mg m⁻³
Monoclinic, P2₁/n	Cu Kα radiation, λ = 1.54178 Å
a = 12.1783 (6) Å	Cell parameters from 7262 reflections
b = 5.7217 (3) Å	θ = 3.0–74.6°
c = 14.8258 (7) Å	µ = 5.46 mm⁻¹
β = 95.740 (1)°	T = 150 K
V = 1027.89 (9) Å³	Block, colourless
Z = 4	0.33 × 0.24 × 0.14 mm

Data collection top

Bruker D8 VENTURE PHOTON 100 CMOS diffractometer	2051 independent reflections
Radiation source: INCOATEC IµS micro-focus source	2020 reflections with I > 2σ(I)
Mirror monochromator	R_int = 0.028
Detector resolution: 10.4167 pixels mm^-1	θ_max = 74.6°, θ_min = 4.5°
ω scans	h = −15→15
Absorption correction: multi-scan (SADABS; Krause et al., 2015)	k = −6→7
T_min = 0.36, T_max = 0.51	l = −18→17
7403 measured reflections

Refinement top

Refinement on F²	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: difference Fourier map
R[F² > 2σ(F²)] = 0.028	All H-atom parameters refined
wR(F²) = 0.074	w = 1/[σ²(F_o²) + (0.0392P)² + 0.599P] where P = (F_o² + 2F_c²)/3
S = 1.05	(Δ/σ)_max = 0.001
2051 reflections	Δρ_max = 0.32 e Å⁻³
169 parameters	Δρ_min = −0.31 e Å⁻³
0 restraints	Extinction correction: SHELXL2018 (Sheldrick, 2015b), Fc^*=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.0137 (7)

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
Cl1	0.09759 (3)	−0.04560 (6)	0.60350 (3)	0.02813 (14)
Cl2	0.08781 (3)	0.37781 (6)	0.71005 (2)	0.02306 (14)
O1	0.40917 (8)	−0.0195 (2)	0.59019 (7)	0.0239 (2)
N1	0.38241 (9)	0.2146 (2)	0.46776 (8)	0.0168 (3)
H1	0.4316 (17)	0.132 (4)	0.4445 (14)	0.031 (5)*
N2	0.16589 (9)	0.4612 (2)	0.47917 (8)	0.0146 (2)
C1	0.25109 (10)	0.5411 (2)	0.42893 (9)	0.0140 (3)
C2	0.22893 (11)	0.7435 (3)	0.37666 (9)	0.0181 (3)
H2	0.1585 (16)	0.826 (4)	0.3825 (13)	0.030 (5)*
C3	0.30118 (12)	0.8234 (3)	0.31737 (10)	0.0210 (3)
H3	0.2849 (15)	0.963 (3)	0.2844 (13)	0.021 (4)*
C4	0.39584 (12)	0.6952 (3)	0.30557 (10)	0.0220 (3)
H4	0.4448 (16)	0.745 (3)	0.2612 (13)	0.025 (4)*
C5	0.41957 (11)	0.4960 (3)	0.35629 (9)	0.0187 (3)
H5	0.4819 (17)	0.403 (3)	0.3483 (13)	0.026 (5)*
C6	0.35036 (11)	0.4207 (2)	0.42047 (9)	0.0144 (3)
C7	0.36854 (10)	0.1586 (3)	0.55461 (9)	0.0168 (3)
C8	0.30141 (11)	0.3298 (3)	0.60421 (9)	0.0182 (3)
H8A	0.3361 (17)	0.485 (4)	0.6036 (14)	0.032 (5)*
H8B	0.2984 (15)	0.268 (3)	0.6639 (14)	0.024 (4)*
C9	0.18779 (10)	0.3589 (2)	0.55513 (9)	0.0139 (3)
C10	0.09010 (11)	0.2661 (2)	0.59849 (9)	0.0166 (3)
H10	0.0224 (15)	0.308 (3)	0.5653 (12)	0.016 (4)*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
Cl1	0.0370 (2)	0.0167 (2)	0.0315 (2)	−0.00336 (14)	0.00773 (16)	−0.00190 (14)
Cl2	0.0278 (2)	0.0245 (2)	0.0190 (2)	−0.00043 (13)	0.01315 (14)	−0.00376 (13)
O1	0.0217 (5)	0.0304 (6)	0.0204 (5)	0.0108 (4)	0.0055 (4)	0.0079 (4)
N1	0.0161 (5)	0.0205 (6)	0.0145 (6)	0.0065 (5)	0.0052 (4)	0.0004 (5)
N2	0.0135 (5)	0.0151 (6)	0.0156 (5)	0.0019 (4)	0.0042 (4)	−0.0011 (4)
C1	0.0135 (6)	0.0159 (7)	0.0129 (6)	−0.0013 (5)	0.0027 (5)	−0.0012 (5)
C2	0.0187 (6)	0.0172 (7)	0.0183 (7)	0.0011 (5)	0.0019 (5)	−0.0001 (5)
C3	0.0257 (7)	0.0172 (7)	0.0201 (7)	−0.0044 (6)	0.0015 (5)	0.0029 (6)
C4	0.0198 (7)	0.0273 (8)	0.0196 (7)	−0.0087 (6)	0.0051 (5)	0.0013 (6)
C5	0.0136 (6)	0.0252 (7)	0.0180 (7)	−0.0019 (5)	0.0043 (5)	−0.0010 (6)
C6	0.0134 (6)	0.0171 (6)	0.0129 (6)	−0.0005 (5)	0.0013 (5)	−0.0019 (5)
C7	0.0119 (6)	0.0233 (7)	0.0151 (6)	0.0025 (5)	0.0012 (5)	0.0005 (5)
C8	0.0142 (6)	0.0281 (8)	0.0125 (6)	0.0044 (5)	0.0019 (5)	−0.0015 (6)
C9	0.0132 (6)	0.0153 (6)	0.0136 (6)	0.0024 (5)	0.0034 (5)	−0.0025 (5)
C10	0.0166 (6)	0.0177 (7)	0.0162 (6)	0.0014 (5)	0.0055 (5)	0.0010 (5)

Geometric parameters (Å, º) top

Cl1—C10	1.7868 (15)	C3—C4	1.392 (2)
Cl2—C10	1.7761 (14)	C3—H3	0.95 (2)
O1—C7	1.2288 (18)	C4—C5	1.380 (2)
N1—C7	1.3539 (18)	C4—H4	0.97 (2)
N1—C6	1.4068 (18)	C5—C6	1.4006 (19)
N1—H1	0.86 (2)	C5—H5	0.94 (2)
N2—C9	1.2737 (18)	C7—C8	1.5130 (19)
N2—C1	1.4124 (17)	C8—C9	1.5068 (18)
C1—C2	1.405 (2)	C8—H8A	0.99 (2)
C1—C6	1.4080 (18)	C8—H8B	0.96 (2)
C2—C3	1.382 (2)	C9—C10	1.5045 (18)
C2—H2	0.99 (2)	C10—H10	0.949 (18)

C7—N1—C6	128.15 (12)	C5—C6—C1	119.36 (13)
C7—N1—H1	114.2 (14)	N1—C6—C1	124.31 (12)
C6—N1—H1	115.4 (14)	O1—C7—N1	121.44 (13)
C9—N2—C1	121.01 (11)	O1—C7—C8	122.85 (13)
C2—C1—C6	118.27 (12)	N1—C7—C8	115.71 (12)
C2—C1—N2	116.55 (11)	C9—C8—C7	110.57 (11)
C6—C1—N2	124.84 (12)	C9—C8—H8A	105.7 (12)
C3—C2—C1	121.60 (13)	C7—C8—H8A	109.1 (12)
C3—C2—H2	120.6 (12)	C9—C8—H8B	111.6 (11)
C1—C2—H2	117.7 (12)	C7—C8—H8B	106.6 (12)
C2—C3—C4	119.59 (14)	H8A—C8—H8B	113.3 (17)
C2—C3—H3	119.6 (11)	N2—C9—C10	115.81 (11)
C4—C3—H3	120.8 (11)	N2—C9—C8	125.35 (12)
C5—C4—C3	119.84 (13)	C10—C9—C8	118.82 (12)
C5—C4—H4	120.1 (12)	C9—C10—Cl2	110.96 (10)
C3—C4—H4	120.1 (12)	C9—C10—Cl1	109.31 (9)
C4—C5—C6	121.12 (13)	Cl2—C10—Cl1	109.03 (7)
C4—C5—H5	121.6 (12)	C9—C10—H10	111.8 (11)
C6—C5—H5	117.3 (12)	Cl2—C10—H10	107.3 (10)
C5—C6—N1	116.14 (12)	Cl1—C10—H10	108.4 (11)

C9—N2—C1—C2	−147.75 (13)	N2—C1—C6—N1	−6.1 (2)
C9—N2—C1—C6	39.04 (19)	C6—N1—C7—O1	−173.53 (13)
C6—C1—C2—C3	0.7 (2)	C6—N1—C7—C8	5.9 (2)
N2—C1—C2—C3	−172.94 (13)	O1—C7—C8—C9	−122.19 (15)
C1—C2—C3—C4	3.1 (2)	N1—C7—C8—C9	58.41 (16)
C2—C3—C4—C5	−3.2 (2)	C1—N2—C9—C10	−175.53 (11)
C3—C4—C5—C6	−0.6 (2)	C1—N2—C9—C8	5.9 (2)
C4—C5—C6—N1	179.62 (13)	C7—C8—C9—N2	−70.12 (18)
C4—C5—C6—C1	4.4 (2)	C7—C8—C9—C10	111.35 (14)
C7—N1—C6—C5	146.34 (14)	N2—C9—C10—Cl2	−124.87 (11)
C7—N1—C6—C1	−38.7 (2)	C8—C9—C10—Cl2	53.79 (15)
C2—C1—C6—C5	−4.42 (19)	N2—C9—C10—Cl1	114.86 (12)
N2—C1—C6—C5	168.68 (12)	C8—C9—C10—Cl1	−66.48 (14)
C2—C1—C6—N1	−179.21 (12)

Hydrogen-bond geometry (Å, º) top

Cg1 is the centroid of the C1–C6 benzene ring.

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1···O1ⁱ	0.86 (2)	2.15 (2)	2.977 (2)	160 (2)
C3—H3···Cg1ⁱⁱ	0.95 (2)	2.66 (2)	3.450 (2)	142 (1)

Symmetry codes: (i) −x+1, −y, −z+1; (ii) −x+1/2, y+1/2, −z+1/2.

Funding information

The support of NSF–MRI grant No. 1228232 for the purchase of the diffractometer and Tulane University for support of the Tulane Crystallography Laboratory are gratefully acknowledged.

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Volume 75| Part 1| January 2019| Pages 33-37

https://doi.org/10.1107/S205698901801681X

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research communications\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Crystal structure and Hirshfeld surface analysis of a new benzodiazepine derivative: 4-di­chloro­methyl-2,3-di­hydro-1H-1,5-benzodiazepin-2-one

1. Chemical context

2. Structural commentary

3. Supra­molecular features

4. Database survey

5. Hirshfeld surface analysis

6. Synthesis and crystallization

7. Refinement

Supporting information

Funding information

References

research communications

Crystal structure and Hirshfeld surface analysis of a new benzodiazepine derivative: 4-dichloromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

3. Supramolecular features