Crystal structure and Hirshfeld surface analysis of 2-[(2-oxo-2H-chromen-4-yl)­oxy]acetic acid dimethyl sulfoxide monosolvate

Syed Abuthahir, S.; NizamMohideen, M.; Viswanathan, V.; Govindhan, M.; Subramanian, K.

doi:10.1107/S2056989019009447

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ISSN: 2056-9890

Volume 75| Part 8| August 2019| Pages 1123-1127

https://doi.org/10.1107/S2056989019009447

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Crystal structure and Hirshfeld surface analysis of 2-[(2-oxo-2H-chromen-4-yl)oxy]acetic acid dimethyl sulfoxide monosolvate

S. Syed Abuthahir,^a M. NizamMohideen,^a ^* V. Viswanathan,^b M. Govindhan ^c,^d and K. Subramanian ^c

^aPG & Research Department of Physics, The New College (Autonomous), University of Madras, Chennai 600 014, Tamil Nadu, India, ^bDepartment of Biophysics, All India Institute of Medical Science, New Delhi 110 029, India, ^cDepartment of Chemistry, Anna University, Chennai 600 025, India, and ^dOrchid Chemicals & Pharmaceuticals Ltd, R&D Centre, Sholinganallur, Chennai 600 119, India
^*Correspondence e-mail: mnizam.new@gmail.com

Edited by L. Van Meervelt, Katholieke Universiteit Leuven, Belgium (Received 21 May 2019; accepted 1 July 2019; online 9 July 2019)

The title compound, C₁₁H₈O₅·(CH₃)₂SO, is a new coumarin derivative. The asymmetric unit contains two coumarin molecules (A and B) and two dimethylsulfoxide solvent molecules (A and B). The dihedral angle between the pyran and benzene rings in the chromene moiety is 3.56 (2)° for molecule A and 1.83 (2)° for molecule B. In molecule A, the dimethyl sulfoxide sulfur atom is disordered over two positions with a refined occupancy ratio of 0.782 (5):0.218 (5). In the crystal, molecules are linked by O—H⋯O hydrogen bonds, forming chains running along the c-axis direction. The chains are linked by C—H⋯O hydrogen bonds, forming layers parallel to the ac plane. In addition, there are also C—H⋯π and π–π interactions present within the layers. The intermolecular contacts in the crystal have been analysed using Hirshfeld surface analysis and two-dimensional fingerprint plots, which indicate that the most important contributions to the packing are from H⋯H (33.9%) and O⋯H/H⋯O (41.2%) contacts.

Keywords: crystal structure; chromen; acetamide; pyran; dimethyl sulfoxide; hydrogen bonding; C—H⋯π interactions; offset π–π interactions; Hirshfeld surface analysis.

CCDC reference: 1891495

1. Chemical context

Coumarin and its derivatives represent one of the most active classes of compounds, possessing a wide spectrum of biological activity. The synthesis, and pharmacological and other properties of coumarin derivatives have been studied intensively and reviewed (Syed Abuthahir et al., 2019 ; Kumar et al., 2015 ; Kubrak et al., 2017 ; Srikrishna et al., 2018 ; Venugopala et al., 2013 ). Many of these compounds have proven to be active as antibacterial, antifungal, anti-inflammatory, anticoagulant, anti-HIV and antitumor agents (Govindhan, Subramanian, Chennakesava Rao et al., 2015 ; Govindhan, Subramanian, Sridharan et al., 2015 ). Sulfur-containing isocoumarins (Henderson & Hill, 1982 ), fluorine-containing isocoumarins (Babar et al., 2008 ) and chlorine-containing isocoumarins (Abid et al., 2008 ) have also been studied. In view of the importance of their natural occurrence, biological, pharmacological and medicinal activities, and their use as synthetic intermediates, we have synthesized the title derivative 2-[(2-oxo-2H-chromen-4-yl)oxy]acetic acid dimethyl sulfoxide monosolvate, and report herein on its crystal structure and Hirshfeld surface analysis.

2. Structural commentary

The molecular structure and conformation of the two independent molecules, A and B in the asymmetric unit, are shown in Fig. 1. The bond lengths and angles in both molecules are very similar. The normal probability plot analyses (International Tables for X-ray Crystallography, 1974, Vol. IV, pp. 293–309) for both bond lengths and angles show that the differences between the two symmetry-independent molecules are of a statistical nature. The structural overlay of the two molecules is shown in Fig. 2 (r.m.s. deviation = 0.098 Å).

Figure 1
The molecular structure of the compound, with the atom labelling. Displacement ellipsoids are drawn at the 30% probability level.

Figure 2
A view of the molecule overlay of inverted molecule B (red) on molecule A (blue), with an r.m.s. deviation of 0.126 Å.

The 1H-isochromene moiety is planar (r.m.s. deviation = 0.001 Å for molecule A and 0.015 Å for molecule B) and atoms O2A and O2B deviate from this mean plane by 0.007 (3) and 0.039 (3) Å, respectively. The dihedral angle between the pyran and benzene rings in the chromene moiety is 3.56 (16)° for molecule A and 1.83 (16)° for molecule B; this value is in agreement with those found in analogous coumarin derivatives (Dobson & Gerkin, 1996 ; Kokila et al., 1996 ). In molecule A, the dimethyl sulfoxide sulfur atom is disordered over two positions with refined occupancies of 0.782 (5) and 0.218 (5).

The title compound exhibits structural similarities with those of two new coumarin derivatives: 2-(4-{2-[(2-oxo-2H-chromen-4-yl)oxy]acetyl}piperazin-1-yl)acetamide (Govindhan, Subramanian, Chennakesava Rao et al., 2015) and N-(2,4-dimethoxybenzyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide (Syed Abuthahir et al., 2019).

3. Supramolecular features

The crystal structure features O—H⋯O and C—H⋯O hydrogen bonds (Table 1; Fig. 3). In the crystal, the A and B molecules are linked by O—H⋯O hydrogen bonds, forming chains running along the c-axis direction. The chains are linked by C—H⋯O hydrogen bonds, forming layers parallel to the ac plane. C—H⋯π (Table 1) and π–π interactions are present within the layers. The observed π–π interactions involve the pyran ring of the chromene ring system and the benzene ring [Cg1⋯Cg3^iv = 3.864 (2), Cg1⋯Cg4^iv = 3.509 (2) and Cg2⋯Cg3^iv 3.572 (2) Å where Cg1, Cg2, Cg3 and Cg4 are the centroids of rings O1A/C1A/C6A–C9A, C1A–C6A, O1B/C1B/C6B–C9B, and C1B–C6B, respectively; symmetry code: (iv) x, 1 + y, z].

Table 1
Hydrogen-bond geometry (Å, °)

Cg2 is the centroid of the C1A–C6A ring.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O4A—H4A1⋯O6A	0.82	1.82	2.621 (5)	167
O4B—H4B1⋯S1Bⁱ	0.82	2.70	3.479 (3)	159
O4B—H4B1⋯O6Bⁱ	0.82	1.78	2.595 (4)	169
C10B—H10A⋯O2A	0.97	2.49	3.423 (4)	161
C10B—H10B⋯O6Bⁱⁱ	0.97	2.37	3.266 (4)	153
C10A—H10C⋯O6Aⁱⁱⁱ	0.97	2.38	3.330 (5)	165
C10A—H10D⋯O2B	0.97	2.40	3.324 (4)	159
C4B—H4B⋯Cg2ⁱ	0.93	2.88	3.552 (3)	130
Symmetry codes: (i) $[x, -y+{\script{3\over 2}}, z+{\script{1\over 2}}]$ ; (ii) -x+1, -y+1, -z+1; (iii) -x, -y+2, -z+1.

Figure 3
A view along the b axis of the crystal packing of the title compound. The hydrogen bonds (Table 1

) are shown as dashed lines, and H atoms not involved in hydrogen bonding have been omitted.

4. Hirshfeld surface analysis

A recent article by Tiekink and collaborators (Tan et al., 2019 ) reviews and describes the uses and utility of Hirshfeld surface analysis (Spackman & Jayatilaka, 2009 ), and the associated two-dimensional fingerprint plots (McKinnon et al., 2007 ), to analyse intermolecular contacts in crystals. The various calculations for the title compound were performed with CrystalExplorer17 (Turner et al., 2017 ).

The Hirshfeld surface of the title compound mapped over d_norm is shown in Fig. 4, and the intermolecular contacts are illustrated in Fig. 5. They are colour-mapped with the normalized contact distance, d_norm, ranging from red (distances shorter than the sum of the van der Waals radii) through white to blue (distances longer than the sum of the van der Waals radii). The d_norm surface was mapped over a fixed colour scale of 0.774 (red) to 1.381 (blue) for the title compound, where the red spots indicate the intermolecular contacts involved in the hydrogen bonding.

Figure 4
The Hirshfeld surface of the title compound, mapped over d_norm.

Figure 5
A view of the Hirshfeld surface mapped over d_norm, showing the various intermolecular contacts in the crystal of the title compound.

The fingerprint plots are given in Fig. 6. They reveal that the principal intermolecular contacts are H⋯H at 33.9% (Fig. 6b) and O⋯H/H⋯O at 41.2% (Fig. 6c), followed by the C⋯H/H⋯C contacts at 9.6% (Fig. 6d), C⋯C contacts at 6.3% (Fig. 6e) and S⋯H/H⋯S contacts at 3.9% (Fig. 6f).

Figure 6
(a) The full two-dimensional fingerprint plot for the title compound, and those delineated into (b) H⋯H, (c) O⋯H/H⋯O, (d) C⋯H/H⋯C, (e) C⋯C and (f) S⋯H/H⋯S contacts.

5. Database survey

A search of the Cambridge Structural Database (Web CSD version 5.39; March 9, 2018; Groom et al., 2016 ) gave more than 35 hits for both linear and angular pyranocoumarin (psoralene class) structures. They include seselin (amyrolin) [refcodes AMYROL (Kato, 1970 ) and AMYROL01 (Bauri et al., 2006 )], 2,3-dihydroxy-9-hydroxy-2(1-hydroxy-1-methylethyl)-7H-furo-[3,2-g][1]-benzopyran-7-one monohydrate (FUGVOS; Thailambal & Pattabhi, 1987 ), bromohydroxyseselin (XARQAL; Bauri et al., 2017a ), dibromomomethoxyseselin (VAPKOP; Bauri et al., 2017b ), and a number of structures with various substituents at C3 and C4, many of which are natural products.

Intramolecular C—H⋯O short contacts similar to those in the title compound are found in five compounds in the CSD: 1-(1-pyrrolidinylcarbonyl)cyclopropyl sulfamate (LISLAB; Morin et al., 2007 ), 2-[3′-(4"-chlorophenyl)-4′,6′-dimethoxyindol-7′-yl]glyoxyl-1-pyrrolidine (PEQHAU; Black et al., 1997 ), [2-hydroxy-5-(2-hydroxybenzoyl)phenyl](pyrrolidin-1-yl)methanone (QIBBEJ; Holtz et al., 2007 ), 2-methoxy-1-(1-pyrrolidinylcarbonyl)naphthalene (SIHNAZ; Sakamoto et al., 2007 ) and (4S,5S)-4,5-bis(pyrrolidinylcarbonyl)-2,2-dimethyl-1,3-dioxolane (TAJDIR; Garcia et al., 1991 ).

6. Synthesis and crystallization

A solution of lithium hydroxide (0.24 g, 1.2 mol eq.) in water (4 mL) was added to ethyl 2-(2-oxo-2H-chromen-4-yloxy) acetate (2.0 g, 1.0 mol eq.) in THF (10 mL) at 273 K and stirred at 273 K for 1 h. Completion of the reaction was confirmed by TLC (mobile phase ethyl acetate/hexane) and THF was distilled off using a rotavapor. The obtained solution was washed with ethyl acetate (20 mL). The aqueous layer was acidified with 2N HCl (pH 1.0–2.0) and the obtained solid was filtered, washed with hexane and dried under vacuum to give as white solid. The purified compound was recrystallized using dimethyl sulfoxide as solvent.

7. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 2. The H atoms were positioned geometrically and constrained to ride on their parent atoms: C—H = 0.93–0.97Å with U_iso(H) = 1.5U_eq(C-methyl) or 1.2U_eq(C) for other H atoms. In molecule A, the sulfur atom of the sulfinyldimethane group is disordered over two positions with refined occupancies of 0.782 (5) and 0.218 (5). In the final cycles of refinement, five outliers were omitted.

Table 2
Experimental details

Crystal data
Chemical formula	C₁₁H₈O₅·C₂H₆OS
M_r	298.30
Crystal system, space group	Monoclinic, P2₁/c
Temperature (K)	293
a, b, c (Å)	23.1461 (12), 8.2631 (4), 14.6374 (8)
β (°)	97.687 (4)
V (Å³)	2774.4 (2)
Z	8
Radiation type	Mo Kα
μ (mm⁻¹)	0.26
Crystal size (mm)	0.25 × 0.18 × 0.12

Data collection
Diffractometer	Bruker Kappa APEXII CCD
Absorption correction	Multi-scan (SADABS; Bruker, 2008 )
T_min, T_max	0.742, 0.852
No. of measured, independent and observed [I > 2σ(I)] reflections	25798, 6824, 2743
R_int	0.119
(sin θ/λ)_max (Å⁻¹)	0.666

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.063, 0.208, 0.87
No. of reflections	6824
No. of parameters	376
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.69, −0.42
Computer programs: APEX2 and SAINT (Bruker, 2008), SHELXS2018 (Sheldrick, 2008 ), SHELXL2018 (Sheldrick, 2015 ), ORTEP-3 for Windows and Mercury (Macrae et al., 2008 ), WinGX (Farrugia, 2012 ); Mercury (Macrae et al., 2008), publCIF (Westrip, 2010 ) and PLATON (Spek, 2009 ).

Supporting information

CCDC reference: 1891495

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S2056989019009447/vm2218sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989019009447/vm2218Isup2.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2056989019009447/vm2218Isup3.cml

checkCIF report

Computing details top

Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT (Bruker, 2008); program(s) used to solve structure: SHELXS2018 (Sheldrick, 2008); program(s) used to refine structure: SHELXL2018 (Sheldrick, 2015); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012) and Mercury (Macrae et al., 2008); software used to prepare material for publication: WinGX (Farrugia, 2012), publCIF (Westrip, 2010) and PLATON (Spek, 2009).

2-[(2-Oxo-2H-chromen-4-yl)oxy]acetic acid dimethyl sulfoxide monosolvate top

Crystal data top

C₁₁H₈O₅·C₂H₆OS	F(000) = 1248
M_r = 298.30	D_x = 1.428 Mg m⁻³
Monoclinic, P2₁/c	Mo Kα radiation, λ = 0.71073 Å
a = 23.1461 (12) Å	Cell parameters from 6824 reflections
b = 8.2631 (4) Å	θ = 1.8–28.3°
c = 14.6374 (8) Å	µ = 0.26 mm⁻¹
β = 97.687 (4)°	T = 293 K
V = 2774.4 (2) Å³	Block, colourless
Z = 8	0.25 × 0.18 × 0.12 mm

Data collection top

Bruker Kappa APEXII CCD diffractometer	2743 reflections with I > 2σ(I)
ω and φ scans	R_int = 0.119
Absorption correction: multi-scan (SADABS; Bruker, 2008)	θ_max = 28.3°, θ_min = 1.8°
T_min = 0.742, T_max = 0.852	h = −30→30
25798 measured reflections	k = −10→10
6824 independent reflections	l = −19→19

Refinement top

Refinement on F²	0 restraints
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F² > 2σ(F²)] = 0.063	H-atom parameters constrained
wR(F²) = 0.208	w = 1/[σ²(F_o²) + (0.1053P)²] where P = (F_o² + 2F_c²)/3
S = 0.87	(Δ/σ)_max < 0.001
6824 reflections	Δρ_max = 0.69 e Å⁻³
376 parameters	Δρ_min = −0.41 e Å⁻³

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq	Occ. (<1)
C13A	−0.04399 (18)	0.4312 (5)	0.3443 (3)	0.0728 (13)
H13A	−0.070292	0.463777	0.386381	0.109*
H13B	−0.039226	0.315849	0.346833	0.109*
H13C	−0.059577	0.462937	0.282872	0.109*
C13B	0.4520 (2)	0.3039 (6)	0.5340 (4)	0.0918 (16)
H13D	0.491305	0.265054	0.546953	0.138*
H13E	0.427430	0.243383	0.569514	0.138*
H13F	0.450767	0.416386	0.550058	0.138*
C12B	0.4320 (2)	0.0677 (5)	0.4079 (4)	0.0834 (15)
H12A	0.419331	0.033276	0.345850	0.125*
H12B	0.407847	0.018839	0.448683	0.125*
H12C	0.471795	0.035236	0.425574	0.125*
S1B	0.42683 (4)	0.27960 (14)	0.41469 (9)	0.0666 (4)
C8B	0.27020 (14)	0.7563 (4)	0.6754 (2)	0.0410 (9)
H8B	0.286314	0.852257	0.657309	0.049*
C8A	0.22217 (14)	1.1613 (4)	0.5296 (2)	0.0388 (8)
H8A	0.206427	1.062620	0.544340	0.047*
C1A	0.21016 (13)	1.4456 (4)	0.4892 (2)	0.0343 (8)
C1B	0.28007 (13)	0.4732 (4)	0.7173 (2)	0.0365 (8)
C9A	0.18699 (13)	1.2921 (4)	0.5157 (2)	0.0356 (8)
C6B	0.22279 (14)	0.4729 (4)	0.7336 (2)	0.0374 (8)
C7B	0.21038 (14)	0.7526 (4)	0.6883 (3)	0.0408 (9)
C6A	0.26854 (14)	1.4507 (4)	0.4786 (2)	0.0374 (8)
C9B	0.30397 (13)	0.6232 (4)	0.6888 (2)	0.0350 (8)
C10B	0.39088 (14)	0.7553 (4)	0.6567 (3)	0.0450 (9)
H10A	0.365842	0.821170	0.613063	0.054*
H10B	0.425039	0.726291	0.628436	0.054*
C7A	0.28261 (15)	1.1714 (4)	0.5224 (3)	0.0425 (9)
C3A	0.20154 (16)	1.7230 (4)	0.4385 (3)	0.0486 (10)
H3A	0.179056	1.815309	0.424815	0.058*
C4A	0.25956 (17)	1.7231 (4)	0.4274 (3)	0.0502 (10)
H4A	0.275975	1.815759	0.405586	0.060*
C5A	0.29396 (15)	1.5876 (4)	0.4480 (3)	0.0451 (9)
H5A	0.333355	1.588921	0.441346	0.054*
C11B	0.40938 (15)	0.8519 (4)	0.7420 (3)	0.0484 (10)
C5B	0.19577 (16)	0.3353 (4)	0.7620 (3)	0.0469 (9)
H5B	0.157087	0.338287	0.772786	0.056*
C3B	0.28513 (17)	0.1906 (4)	0.7585 (3)	0.0496 (10)
H3B	0.306236	0.094800	0.767083	0.060*
C11A	0.08288 (14)	1.0434 (4)	0.4690 (3)	0.0436 (9)
C4B	0.22748 (17)	0.1949 (4)	0.7737 (3)	0.0501 (10)
H4B	0.209965	0.101248	0.792202	0.060*
C2A	0.17680 (15)	1.5856 (4)	0.4699 (2)	0.0423 (9)
H2A	0.137684	1.586033	0.478387	0.051*
C2B	0.31131 (15)	0.3286 (4)	0.7305 (2)	0.0429 (9)
H2B	0.350099	0.325359	0.720247	0.052*
C12A	0.05788 (19)	0.4705 (5)	0.2783 (3)	0.0771 (14)
H12D	0.063612	0.355485	0.278054	0.116*
H12E	0.033342	0.502275	0.223138	0.116*
H12F	0.094887	0.524054	0.281072	0.116*
C10A	0.10247 (14)	1.1508 (4)	0.5512 (3)	0.0421 (9)
H10C	0.068964	1.179268	0.581190	0.050*
H10D	0.129589	1.091455	0.595162	0.050*
O2B	0.17604 (10)	0.8632 (3)	0.6759 (2)	0.0583 (7)
O2A	0.30431 (9)	1.3180 (3)	0.49654 (17)	0.0443 (6)
O3B	0.36054 (9)	0.6118 (3)	0.67566 (17)	0.0447 (6)
O1A	0.31786 (11)	1.0636 (3)	0.5349 (2)	0.0623 (8)
O1B	0.18850 (9)	0.6100 (3)	0.71963 (17)	0.0455 (6)
O3A	0.13002 (9)	1.2960 (2)	0.52488 (17)	0.0422 (6)
O4A	0.06268 (12)	0.9068 (3)	0.49773 (19)	0.0586 (8)
H4A1	0.050295	0.850621	0.453194	0.088*
O4B	0.43802 (13)	0.9821 (3)	0.7219 (2)	0.0710 (9)
H4B1	0.445425	1.038184	0.768236	0.106*
O7B	0.47513 (11)	0.3440 (3)	0.3654 (2)	0.0764 (10)
O6A	0.01623 (13)	0.6980 (4)	0.3745 (3)	0.0979 (13)
O5B	0.39977 (12)	0.8143 (4)	0.8178 (2)	0.0682 (9)
O5A	0.08491 (13)	1.0796 (4)	0.3906 (2)	0.0718 (9)
S1A	0.02436 (6)	0.52545 (19)	0.37557 (13)	0.0507 (6)	0.782 (5)
S1'A	0.0025 (3)	0.5829 (7)	0.3230 (5)	0.057 (2)	0.218 (5)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C13A	0.067 (3)	0.069 (3)	0.085 (4)	−0.020 (2)	0.016 (2)	−0.009 (3)
C13B	0.086 (3)	0.094 (4)	0.090 (4)	−0.016 (3)	−0.010 (3)	−0.007 (3)
C12B	0.088 (3)	0.070 (3)	0.090 (4)	−0.011 (3)	0.001 (3)	0.004 (3)
S1B	0.0449 (6)	0.0689 (7)	0.0854 (10)	0.0084 (5)	0.0070 (6)	0.0063 (6)
C8B	0.0393 (18)	0.0338 (18)	0.051 (3)	−0.0033 (15)	0.0085 (16)	0.0001 (17)
C8A	0.0399 (18)	0.0315 (17)	0.045 (2)	−0.0033 (14)	0.0075 (16)	0.0018 (16)
C1A	0.0360 (17)	0.0355 (18)	0.032 (2)	0.0010 (14)	0.0049 (15)	−0.0044 (15)
C1B	0.0380 (18)	0.0345 (18)	0.036 (2)	−0.0004 (15)	0.0007 (15)	−0.0001 (16)
C9A	0.0353 (17)	0.0366 (19)	0.035 (2)	−0.0010 (14)	0.0033 (15)	−0.0007 (15)
C6B	0.0432 (19)	0.0366 (18)	0.032 (2)	−0.0007 (15)	0.0052 (16)	−0.0041 (16)
C7B	0.0416 (19)	0.039 (2)	0.042 (2)	−0.0008 (16)	0.0051 (16)	−0.0021 (17)
C6A	0.0445 (19)	0.0345 (18)	0.033 (2)	−0.0015 (15)	0.0059 (16)	−0.0057 (16)
C9B	0.0328 (16)	0.0382 (18)	0.033 (2)	0.0004 (14)	0.0028 (15)	−0.0073 (16)
C10B	0.0347 (17)	0.043 (2)	0.059 (3)	−0.0011 (16)	0.0159 (17)	0.0030 (19)
C7A	0.0432 (19)	0.040 (2)	0.044 (2)	0.0032 (16)	0.0033 (17)	−0.0044 (17)
C3A	0.057 (2)	0.041 (2)	0.048 (3)	0.0097 (18)	0.0062 (19)	0.0031 (18)
C4A	0.071 (3)	0.039 (2)	0.041 (3)	−0.0134 (19)	0.011 (2)	0.0038 (18)
C5A	0.047 (2)	0.045 (2)	0.045 (3)	−0.0090 (17)	0.0108 (18)	−0.0043 (18)
C11B	0.0358 (19)	0.042 (2)	0.069 (3)	−0.0054 (16)	0.014 (2)	−0.004 (2)
C5B	0.050 (2)	0.051 (2)	0.040 (3)	−0.0126 (18)	0.0074 (17)	0.0001 (18)
C3B	0.066 (3)	0.038 (2)	0.042 (3)	0.0018 (18)	−0.0043 (19)	0.0061 (18)
C11A	0.0343 (18)	0.044 (2)	0.053 (3)	−0.0022 (16)	0.0095 (18)	0.000 (2)
C4B	0.070 (3)	0.041 (2)	0.038 (3)	−0.0132 (19)	0.0029 (19)	0.0051 (17)
C2A	0.0445 (19)	0.041 (2)	0.041 (2)	0.0018 (16)	0.0038 (17)	0.0004 (17)
C2B	0.0436 (19)	0.042 (2)	0.042 (2)	0.0022 (16)	0.0001 (17)	−0.0009 (17)
C12A	0.070 (3)	0.076 (3)	0.092 (4)	−0.003 (2)	0.034 (3)	−0.030 (3)
C10A	0.0368 (18)	0.0411 (19)	0.050 (3)	−0.0006 (15)	0.0109 (17)	0.0002 (18)
O2B	0.0477 (15)	0.0467 (15)	0.081 (2)	0.0112 (12)	0.0088 (14)	0.0038 (14)
O2A	0.0367 (12)	0.0435 (14)	0.0539 (18)	0.0010 (10)	0.0101 (11)	0.0052 (12)
O3B	0.0342 (13)	0.0378 (13)	0.0629 (19)	−0.0018 (10)	0.0094 (12)	0.0006 (12)
O1A	0.0475 (15)	0.0520 (16)	0.088 (2)	0.0149 (13)	0.0105 (14)	0.0099 (15)
O1B	0.0392 (13)	0.0430 (14)	0.0561 (18)	0.0005 (11)	0.0123 (12)	0.0030 (12)
O3A	0.0340 (12)	0.0348 (13)	0.0583 (18)	0.0003 (10)	0.0085 (11)	0.0034 (11)
O4A	0.0630 (17)	0.0405 (15)	0.072 (2)	−0.0125 (13)	0.0081 (15)	−0.0035 (14)
O4B	0.0748 (19)	0.0550 (17)	0.085 (2)	−0.0232 (15)	0.0173 (18)	−0.0107 (16)
O7B	0.0494 (16)	0.074 (2)	0.110 (3)	0.0176 (14)	0.0238 (16)	0.0302 (18)
O6A	0.074 (2)	0.073 (2)	0.153 (4)	−0.0240 (17)	0.040 (2)	−0.065 (2)
O5B	0.074 (2)	0.074 (2)	0.058 (2)	−0.0207 (15)	0.0138 (16)	−0.0042 (17)
O5A	0.089 (2)	0.079 (2)	0.049 (2)	−0.0262 (17)	0.0148 (17)	−0.0035 (17)
S1A	0.0455 (8)	0.0497 (9)	0.0550 (13)	0.0045 (6)	−0.0008 (7)	−0.0059 (8)
S1'A	0.059 (3)	0.049 (3)	0.061 (5)	0.004 (3)	0.002 (3)	0.007 (3)

Geometric parameters (Å, º) top

C13A—S1'A	1.708 (6)	C10B—H10A	0.9700
C13A—S1A	1.768 (4)	C10B—H10B	0.9700
C13A—H13A	0.9600	C7A—O1A	1.205 (4)
C13A—H13B	0.9600	C7A—O2A	1.384 (4)
C13A—H13C	0.9600	C3A—C2A	1.378 (5)
C13B—S1B	1.777 (5)	C3A—C4A	1.374 (5)
C13B—H13D	0.9600	C3A—H3A	0.9300
C13B—H13E	0.9600	C4A—C5A	1.384 (5)
C13B—H13F	0.9600	C4A—H4A	0.9300
C12B—S1B	1.759 (5)	C5A—H5A	0.9300
C12B—H12A	0.9600	C11B—O5B	1.201 (5)
C12B—H12B	0.9600	C11B—O4B	1.317 (4)
C12B—H12C	0.9600	C5B—C4B	1.372 (5)
S1B—O7B	1.506 (3)	C5B—H5B	0.9300
C8B—C9B	1.348 (4)	C3B—C2B	1.379 (5)
C8B—C7B	1.423 (4)	C3B—C4B	1.383 (5)
C8B—H8B	0.9300	C3B—H3B	0.9300
C8A—C9A	1.352 (4)	C11A—O5A	1.193 (4)
C8A—C7A	1.420 (4)	C11A—O4A	1.312 (4)
C8A—H8A	0.9300	C11A—C10A	1.515 (5)
C1A—C6A	1.382 (4)	C4B—H4B	0.9300
C1A—C2A	1.399 (4)	C2A—H2A	0.9300
C1A—C9A	1.449 (4)	C2B—H2B	0.9300
C1B—C6B	1.378 (4)	C12A—S1'A	1.776 (7)
C1B—C2B	1.396 (4)	C12A—S1A	1.769 (4)
C1B—C9B	1.441 (5)	C12A—H12D	0.9600
C9A—O3A	1.344 (4)	C12A—H12E	0.9600
C6B—C5B	1.388 (5)	C12A—H12F	0.9600
C6B—O1B	1.383 (4)	C10A—O3A	1.436 (4)
C7B—O2B	1.209 (4)	C10A—H10C	0.9700
C7B—O1B	1.384 (4)	C10A—H10D	0.9700
C6A—C5A	1.377 (5)	O4A—H4A1	0.8200
C6A—O2A	1.378 (4)	O4B—H4B1	0.8200
C9B—O3B	1.352 (3)	O6A—S1'A	1.229 (6)
C10B—O3B	1.424 (4)	O6A—S1A	1.438 (3)
C10B—C11B	1.496 (5)

S1A—C13A—H13A	109.5	O2A—C7A—C8A	118.0 (3)
S1A—C13A—H13B	109.5	C2A—C3A—C4A	119.8 (3)
H13A—C13A—H13B	109.5	C2A—C3A—H3A	120.1
S1A—C13A—H13C	109.5	C4A—C3A—H3A	120.1
H13A—C13A—H13C	109.5	C3A—C4A—C5A	121.1 (3)
H13B—C13A—H13C	109.5	C3A—C4A—H4A	119.4
S1B—C13B—H13D	109.5	C5A—C4A—H4A	119.4
S1B—C13B—H13E	109.5	C6A—C5A—C4A	118.5 (3)
H13D—C13B—H13E	109.5	C6A—C5A—H5A	120.8
S1B—C13B—H13F	109.5	C4A—C5A—H5A	120.8
H13D—C13B—H13F	109.5	O5B—C11B—O4B	125.3 (4)
H13E—C13B—H13F	109.5	O5B—C11B—C10B	124.4 (3)
S1B—C12B—H12A	109.5	O4B—C11B—C10B	110.3 (4)
S1B—C12B—H12B	109.5	C4B—C5B—C6B	118.4 (3)
H12A—C12B—H12B	109.5	C4B—C5B—H5B	120.8
S1B—C12B—H12C	109.5	C6B—C5B—H5B	120.8
H12A—C12B—H12C	109.5	C2B—C3B—C4B	119.9 (3)
H12B—C12B—H12C	109.5	C2B—C3B—H3B	120.0
O7B—S1B—C12B	105.3 (2)	C4B—C3B—H3B	120.0
O7B—S1B—C13B	105.3 (2)	O5A—C11A—O4A	125.8 (4)
C12B—S1B—C13B	98.7 (2)	O5A—C11A—C10A	124.8 (3)
C9B—C8B—C7B	121.3 (3)	O4A—C11A—C10A	109.3 (4)
C9B—C8B—H8B	119.4	C5B—C4B—C3B	120.9 (3)
C7B—C8B—H8B	119.4	C5B—C4B—H4B	119.6
C9A—C8A—C7A	121.4 (3)	C3B—C4B—H4B	119.6
C9A—C8A—H8A	119.3	C3A—C2A—C1A	120.4 (3)
C7A—C8A—H8A	119.3	C3A—C2A—H2A	119.8
C6A—C1A—C2A	118.3 (3)	C1A—C2A—H2A	119.8
C6A—C1A—C9A	117.4 (3)	C3B—C2B—C1B	120.6 (3)
C2A—C1A—C9A	124.3 (3)	C3B—C2B—H2B	119.7
C6B—C1B—C2B	117.8 (3)	C1B—C2B—H2B	119.7
C6B—C1B—C9B	117.8 (3)	S1A—C12A—H12D	109.5
C2B—C1B—C9B	124.3 (3)	S1A—C12A—H12E	109.5
O3A—C9A—C8A	125.7 (3)	H12D—C12A—H12E	109.5
O3A—C9A—C1A	114.1 (3)	S1A—C12A—H12F	109.5
C8A—C9A—C1A	120.2 (3)	H12D—C12A—H12F	109.5
C1B—C6B—C5B	122.4 (3)	H12E—C12A—H12F	109.5
C1B—C6B—O1B	121.3 (3)	O3A—C10A—C11A	111.9 (3)
C5B—C6B—O1B	116.3 (3)	O3A—C10A—H10C	109.2
O2B—C7B—O1B	115.5 (3)	C11A—C10A—H10C	109.2
O2B—C7B—C8B	126.6 (3)	O3A—C10A—H10D	109.2
O1B—C7B—C8B	117.9 (3)	C11A—C10A—H10D	109.2
C5A—C6A—O2A	116.3 (3)	H10C—C10A—H10D	107.9
C5A—C6A—C1A	121.9 (3)	C6A—O2A—C7A	121.2 (3)
O2A—C6A—C1A	121.7 (3)	C9B—O3B—C10B	118.8 (2)
C8B—C9B—O3B	126.1 (3)	C7B—O1B—C6B	121.2 (3)
C8B—C9B—C1B	120.4 (3)	C9A—O3A—C10A	118.9 (2)
O3B—C9B—C1B	113.4 (3)	C11A—O4A—H4A1	109.5
O3B—C10B—C11B	112.0 (3)	C11B—O4B—H4B1	109.5
O3B—C10B—H10A	109.2	O6A—S1A—C12A	108.5 (2)
C11B—C10B—H10A	109.2	O6A—S1A—C13A	108.8 (2)
O3B—C10B—H10B	109.2	C12A—S1A—C13A	98.8 (2)
C11B—C10B—H10B	109.2	O6A—S1'A—C13A	124.9 (5)
H10A—C10B—H10B	107.9	O6A—S1'A—C12A	119.4 (5)
O1A—C7A—O2A	115.2 (3)	C13A—S1'A—C12A	100.8 (3)
O1A—C7A—C8A	126.8 (3)

C7A—C8A—C9A—O3A	−177.0 (3)	O3B—C10B—C11B—O5B	−0.3 (5)
C7A—C8A—C9A—C1A	2.4 (5)	O3B—C10B—C11B—O4B	179.0 (3)
C6A—C1A—C9A—O3A	179.9 (3)	C1B—C6B—C5B—C4B	−0.2 (5)
C2A—C1A—C9A—O3A	−3.1 (5)	O1B—C6B—C5B—C4B	177.8 (3)
C6A—C1A—C9A—C8A	0.5 (5)	C6B—C5B—C4B—C3B	0.6 (6)
C2A—C1A—C9A—C8A	177.5 (3)	C2B—C3B—C4B—C5B	−0.4 (6)
C2B—C1B—C6B—C5B	−0.2 (5)	C4A—C3A—C2A—C1A	−1.0 (6)
C9B—C1B—C6B—C5B	−179.4 (3)	C6A—C1A—C2A—C3A	1.9 (5)
C2B—C1B—C6B—O1B	−178.2 (3)	C9A—C1A—C2A—C3A	−175.0 (3)
C9B—C1B—C6B—O1B	2.6 (5)	C4B—C3B—C2B—C1B	0.0 (5)
C9B—C8B—C7B—O2B	−178.0 (4)	C6B—C1B—C2B—C3B	0.3 (5)
C9B—C8B—C7B—O1B	3.1 (5)	C9B—C1B—C2B—C3B	179.5 (3)
C2A—C1A—C6A—C5A	−1.4 (5)	O5A—C11A—C10A—O3A	−6.4 (5)
C9A—C1A—C6A—C5A	175.8 (3)	O4A—C11A—C10A—O3A	174.6 (3)
C2A—C1A—C6A—O2A	179.8 (3)	C5A—C6A—O2A—C7A	−176.2 (3)
C9A—C1A—C6A—O2A	−3.1 (5)	C1A—C6A—O2A—C7A	2.8 (5)
C7B—C8B—C9B—O3B	177.7 (3)	O1A—C7A—O2A—C6A	179.0 (3)
C7B—C8B—C9B—C1B	−0.3 (5)	C8A—C7A—O2A—C6A	0.2 (5)
C6B—C1B—C9B—C8B	−2.6 (5)	C8B—C9B—O3B—C10B	8.3 (5)
C2B—C1B—C9B—C8B	178.2 (3)	C1B—C9B—O3B—C10B	−173.6 (3)
C6B—C1B—C9B—O3B	179.2 (3)	C11B—C10B—O3B—C9B	78.5 (4)
C2B—C1B—C9B—O3B	0.0 (5)	O2B—C7B—O1B—C6B	177.8 (3)
C9A—C8A—C7A—O1A	178.7 (4)	C8B—C7B—O1B—C6B	−3.1 (5)
C9A—C8A—C7A—O2A	−2.7 (5)	C1B—C6B—O1B—C7B	0.3 (5)
C2A—C3A—C4A—C5A	−0.6 (6)	C5B—C6B—O1B—C7B	−177.8 (3)
O2A—C6A—C5A—C4A	178.8 (3)	C8A—C9A—O3A—C10A	−0.4 (5)
C1A—C6A—C5A—C4A	−0.1 (5)	C1A—C9A—O3A—C10A	−179.8 (3)
C3A—C4A—C5A—C6A	1.1 (6)	C11A—C10A—O3A—C9A	−84.3 (3)

Hydrogen-bond geometry (Å, º) top

Cg1 is the centroid of the C1A–C6A ring.

D—H···A	D—H	H···A	D···A	D—H···A
O4A—H4A1···O6A	0.82	1.82	2.621 (5)	167
O4B—H4B1···S1Bⁱ	0.82	2.70	3.479 (3)	159
O4B—H4B1···O7Bⁱ	0.82	1.78	2.595 (4)	169
C10B—H10A···O1A	0.97	2.49	3.423 (4)	161
C10B—H10B···O7Bⁱⁱ	0.97	2.37	3.266 (4)	153
C10A—H10C···O6Aⁱⁱⁱ	0.97	2.38	3.330 (5)	165
C10A—H10D···O2B	0.97	2.40	3.324 (4)	159
C4B—H4B···Cg1ⁱ	0.93	2.88	3.552 (3)	130

Symmetry codes: (i) x, −y+3/2, z+1/2; (ii) −x+1, −y+1, −z+1; (iii) −x, −y+2, −z+1.

Acknowledgements

The authors are grateful to the SAIF, IIT Madras, for the data collection.

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