research communications
4,15-Dimethyl-7,12-diazoniatricyclo[10.4.0.02,7]hexadeca-1(12),2,4,6,13,15-hexaene dibromide monohydrate
aDepartment of Chemistry & Biochemistry, The Ohio State University, 484 W. 12th Avenue, Columbus, Ohio, 43210, USA, bCampus Chemical Instrument Center, The Ohio State University, 496 W. 12th Avenue, Columbus, Ohio, 43210, USA, and cDepartment of Chemistry, University of Kentucky, 505 Rose Street, Lexington, Kentucky, 40506, USA
*Correspondence e-mail: behrman.1@osu.edu
The title compound, C16H20N22+·2Br−·H2O (1) is a member of the class of compounds called are quaternary salts of dipyridyls and are especially useful as redox indicators as a result of their large negative one-electron reduction potentials. Compound 1 consists of a dication composed of a pair of 4-methylpyridine rings mutually joined at the 2-position, with a dihedral angle between the pyridine rings of 62.35 (4)°. In addition, the rings are tethered via the pyridine nitrogen atoms by a tetramethylene bridge. Charge balance is provided by a pair of bromide anions, which are hydrogen bonded to a single water molecule [DO⋯Br = 3.3670 (15) and 3.3856 (15) Å]. The of 1, details of an improved synthesis, and a full analysis of its NMR spectra are presented.
Keywords: viologen; crystal structure; atropisomer; synthesis.
CCDC reference: 2023167
1. Chemical context
The title compound (1) is a member of the class of compounds called are quaternary salts of dipyridyls, which have proven useful as redox indicators as a result of their large negative one-electron reduction potentials (Anderson & Patel, 1984). The herbicides, paraquat, and diquat are We found that the literature synthesis of 4,4′-dimethyl-2,2′-dipyridyl-N,N′-tetramethylene dibromide, i.e., 1 (Spotswood & Tanzer, 1967) could be improved by a change in the solvent. We report details of our improved synthesis of 1 along with the and a full analysis of its NMR spectra.
Spotswood & Tanzer (1967) give general directions for the syntheses of a series of bridged dimethyl 2,2′-dipyridyl salts. Our attempts to make the title compound by their directions failed; only a salt of the starting dipyridyl was recovered. Homer & Tomlinson (1960) noted that HBr is formed by dehydrohalogenation of the dibromide. We think that the conditions used by Anderson & Patel (1984), i.e., refluxing o-dichlorobenzene, b.p. 453 K, produced a good deal of HBr, which protonated the dipyridyl, rendering it unreactive. Carrying out the reaction in refluxing xylene (mixed isomers, b.p. ca 413 K) does not produce HBr, but the reaction is slow; after five h, about 50% of the starting dipyridyl was recovered. The quaternization of tertiary is known as the Menschutkin reaction (Menschutkin, 1890). The velocity of this reaction shows a strong dependence on solvent (Abraham & Grellier, 1976), with about a 65,000-fold increase from hexane to DMSO. The addition of nitrobenzene to the solvent gave satisfactory yields of the product in a reasonable time (see Synthesis and crystallization section).
2. Structural commentary
The molecular structure of 1 is shown in Fig. 1. It consists of a dication composed of a pair of 4-methylpyridine rings mutually joined at their 2-positions, with a dihedral angle between the pyridine rings of 62.35 (4)°. In addition, the rings are tethered via the pyridine nitrogen atoms by a tetramethylene bridge. There are no unusual bond lengths or angles. As a result of the two bridges between the pyridine rings, 1 occurs as two and therefore provides an example of atropisomerism (Eliel et al., 1994; Alkorta et al., 2012; Mancinelli et al., 2020). Crystals of 1, however, were centrosymmetric, with P21/n, and are thus strictly racemic. Charge balance is provided by a pair of bromide anions, which are hydrogen bonded to a single water molecule of crystallization [DO⋯Br = 3.3670 (15) and 3.3856 (15) Å] (Table 1).
3. Supramolecular features
Aside from the hydrogen bonds between the water molecule and bromide anions, the only other notable intermolecular contacts are interactions of type C—H⋯Br (Fig. 2, Table 1), with distances that range between 3.5765 (17) and 3.7762 (18) Å for type Cpyridyl⋯Br and 3.6581 (18) to 3.7700 (19) Å for type Cmethylene⋯Br. For comparison, the standard van der Waals radii of C, H, and Br (Bondi, 1964) are 1.2, 1.7, and 1.85 Å, respectively. The percentages of atom⋯atom contact types between asymmetric units were obtained from Hirshfeld-surface fingerprint plots (Figs. S1 and S2 in the supporting information; Spackman & McKinnon, 2002; McKinnon et al., 2004) using CrystalExplorer 17.5 (Turner et al., 2017), and are presented in Table 2.
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4. Database survey
The most similar structures to 1 in the Cambridge Structural Database (CSD, V5.41, update of November 2019; Groom et al., 2016) are BIYTEL, BIYTUB, BIYTOV, BIYVAJ, and BIYTIP (Sanchez et al., 2019). BIYTEL has a trimethylene bridge, BIYTUB has a dimethylene bridge, BIYTOV has a trimethylene bridge but lacks the 4-Me substituents, BIYVAJ has a trimethylene bridge but 5-Me groups instead of 4-Me, and BIYTIP has a dimethylene bridge but is a methanol solvate. CSD entry TMEPYR (Derry & Hamor, 1970) contains a tetramethylene bridge, but lacks 4-Me subsituents. CSD entries DIQUAT (Derry & Hamor, 1969) and DQUATB (Sullivan & Williams, 1976), have dimethylene bridges but also lack the 4-Me substituents. Atomic coordinates for TMEPYR, DIQUAT and DQUATB are, however, not present in the CSD. CSD entry PICGAM (Talele et al., 2018) has a –CH2C6H4CH2– linker and is an acetonitrile solvate. These crystal structures have Br− anions for charge balance and (unless otherwise stated) include water of crystallization. The tetramethylene bridge is present in CSD entries HIJGAI (Hofbauer et al., 1996), YOBWAN (Schmauch et al., 1995), and YUFCOR (Knoch et al., 1995), but these crystal structures feature complex organometallic anions rather than bromide and are not hydrates. The dihedral angle between the two pyridine rings in each structure is strongly dependent on the length of the bridging tether. These range between 15.78–19.01° for dimethylene, 49.40–53.96° for trimethylene, and 63.87–67.15° for tetramethylene [cf. 62.35 (4)° in 1]. In PICGAM, the dihedral angle is 72.64°, presumably as a result of the increased rigidity of the tether.
5. NMR spectroscopic analysis
The low-field NMR spectrum has been well analyzed by Spotswood & Tanzer (1967), with whose data we agree. However, the instruments available in 1967 were not able to resolve the bridge protons. Thummel et al. (1985) reported data on the bipyridyl analog, that is, without the 4,4′-methyl groups. Our data closely match theirs (see especially Fig. 3 of Thummel et al., 1985), showing an identical complex splitting pattern for the four resolved signals. The protons of the methyl group exchange with deuterons in a base-catalyzed reaction (Zoltewicz & Jacobson, 1978). Our NMR sample, which also showed exchange, was neutral. Exchange was prevented by adjusting the `pH' to ∼1 with DCl. This exchange with solvent deuterium led to some deuterium couplings with both protons and carbon and hence multiplicities in the NMR spectra, which were initially puzzling. Calder et al. (1967) discuss the effect of the length of the bridging group on the NMR spectra and the mobility of the structures.
There are eight resonance signals in the 1H NMR spectrum recorded in D2O, including one on the downfield shoulder of the residual water resonance. All but one of the signals are of equal intensity and the one at 2.68 ppm is about three times larger. The 13C NMR spectrum shows eight signals (C1–C8), two of which (C2 and C4) are barely separated. Quantitative measurement using inverse-gated decoupling with a long recycle delay (60 s) shows that the carbon signals are of equal intensity. The 1-D 13C DEPT (Distortionless Enhancement by Polarization Transfer) and 2-D multiplicity-edited 1H–13C HSQC (Heteronuclear Single Quantum Coherence) establish a ratio of 3:2:1 for CH, CH2, and CH3, respectively. Further analysis of 2-D 1H COSY (Correlation Spectroscopy) and 2-D 1H-13C HMBC (Heteronuclear Multiple-Bond Correlation spectroscopy) spectra led to the NMR assignments summarized in Table 3. A selective HMBC focusing on the C2/C4 region was recorded for unambiguous assignments of multiple-bond 1H–13C correlations related to these two carbons. These details together with the 2-D 1H–15N HMBC, which reveals stronger H2/N9 and H4/N9 cross-peaks than H1/N9, clearly establish a symmetric three-ring molecular structure, as shown in Fig. 3, in full agreement with the (Fig. 1).
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The stereospecific assignment of the methylene protons was achieved by a systematic recording of 1-D selective NOESY (Nuclear Overhauser Effect Spectroscopy) and COSY spectra. A stronger NOE was observed between the proton at 4.73 ppm and H1, and thus this resonance was assigned to H6A while the geminal one at 4.03 ppm to H6B. The 1-D selective homonuclear decoupling 1H NMR spectra led to the extraction of J-coupling constants between these methylene protons (Table 3). A large 3J coupling exists between H6B and H7B (11.3 Hz), followed by a sizable 3J coupling between H6A and H7A (6.1 Hz). As a result of the complexity of the spectra, the 3J(H6AH7B) and 3J(H6BH7A) could not be determined, but were estimated to be less than 2 Hz. Also, the 11.1 Hz coupling between H7A and H7B was tentatively assigned to the geminal coupling rather than the one across the C7–C7′ bond.
All NMR spectra were recorded on a Bruker Ascend 700 MHz spectrometer equipped with a TXO cryoprobe at 298 K. Spectra were indirectly referenced to the deuterium lock frequency, set to 4.7 ppm.
6. Synthesis and crystallization
The starting materials were standard commercial samples of 95-98% purity. 4,4′-Dimethyl-2,2′-dipyridyl (0.92 g, 5 mmol) and 1,4-dibromobutane (0.6 mL, 1.08g, 5 mmol) were added to a mixture of 5 mL each of xylene (mixed isomers, b.p. ca 413 K) and nitrobenzene (b.p. 483 K). The mixture was refluxed for about 5 h, during which time a heavy precipitate formed. After cooling, the crude material was filtered and washed with acetone to yield 1.1 g of a tan-colored powder. Paper of this material at pH 7.5 showed (via UV) a small amount of starting material at Rp ca zero and product at Rp −2.2 (Rp is movement relative to picric acid). Crystallization from methanol–acetone gave 0.5–0.6 g (ca 50%) of reddish crystals, m.p. 528–530 K [lit. 528–533 K; Spotswood & Tanzer (1967)], UVmax(water) 271 nm. IR(Nujol): 3456, 3414, 3372, 1632, 1582, 1566, 1514 1312, 1159, 1032, 853 cm−1.
7. Refinement
Crystal data, data collection and structure . All hydrogen atoms were found in difference-Fourier maps. Those attached to carbon were subsequently included in the using riding models, with constrained distances set to 0.95 Å (Csp2H), 0.98 Å (RCH3), and 0.99 Å (R2CH2). Water hydrogen coordinates were refined, but subject to a restraint on the O—H distances (SHELXL command SADI). Uiso(H) parameters were set to values of either 1.2Ueq or 1.5Ueq (RCH3 only) of the attached atom.
details are summarized in Table 4
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Supporting information
CCDC reference: 2023167
https://doi.org/10.1107/S2056989020011147/ex2036sup1.cif
contains datablock I. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989020011147/ex2036Isup2.hkl
Figure S1. DOI: https://doi.org/10.1107/S2056989020011147/ex2036sup3.tif
Figure S2. DOI: https://doi.org/10.1107/S2056989020011147/ex2036sup4.tif
Supporting information file. DOI: https://doi.org/10.1107/S2056989020011147/ex2036Isup5.cml
Data collection: APEX3 (Bruker, 2016); cell
APEX3 (Bruker, 2016); data reduction: APEX3 (Bruker, 2016); program(s) used to solve structure: SHELXT (Sheldrick, 2015a); program(s) used to refine structure: SHELXL2018/3 (Sheldrick, 2015b); molecular graphics: XP in SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELX (Sheldrick, 2008), CIFFIX (Parkin, 2013), and publCIF (Westrip, 2010).C16H20N22+·2(Br−)·H2O | F(000) = 840 |
Mr = 418.17 | Dx = 1.606 Mg m−3 |
Monoclinic, P21/n | Mo Kα radiation, λ = 0.71073 Å |
a = 7.6402 (2) Å | Cell parameters from 9914 reflections |
b = 13.7578 (3) Å | θ = 2.8–27.5° |
c = 16.7691 (3) Å | µ = 4.69 mm−1 |
β = 101.162 (1)° | T = 90 K |
V = 1729.30 (7) Å3 | Irregular shard, pink |
Z = 4 | 0.16 × 0.12 × 0.07 mm |
Bruker D8 Venture dual source diffractometer | 3959 independent reflections |
Radiation source: microsource | 3527 reflections with I > 2σ(I) |
Detector resolution: 7.41 pixels mm-1 | Rint = 0.029 |
φ and ω scans | θmax = 27.5°, θmin = 2.5° |
Absorption correction: multi-scan (SADABS; Krause et al., 2015) | h = −9→9 |
Tmin = 0.562, Tmax = 0.746 | k = −17→17 |
26025 measured reflections | l = −21→21 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.020 | Hydrogen site location: mixed |
wR(F2) = 0.043 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.06 | w = 1/[σ2(Fo2) + (0.0121P)2 + 1.4994P] where P = (Fo2 + 2Fc2)/3 |
3959 reflections | (Δ/σ)max = 0.002 |
198 parameters | Δρmax = 0.38 e Å−3 |
1 restraint | Δρmin = −0.38 e Å−3 |
Experimental. The crystal was mounted using polyisobutene oil on the tip of a fine glass fibre, which was fastened in a copper mounting pin with electrical solder. It was placed directly into the cold gas stream of a liquid-nitrogen based cryostat (Hope, 1994; Parkin & Hope, 1998). Diffraction data were collected with the crystal at 90K, which is standard practice in this laboratory for the majority of flash-cooled crystals. |
Geometry. All s.u.s (except the s.u. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell s.u.s are taken into account individually in the estimation of s.u.s in distances, angles and torsion angles; correlations between s.u.s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell s.u.s is used for estimating s.u.s involving l.s. planes. |
Refinement. Refinement progress was checked using Platon (Spek, 2009) and by an R-tensor (Parkin, 2000). The final model was further checked with the IUCr utility checkCIF. |
x | y | z | Uiso*/Ueq | ||
Br1 | 0.38758 (2) | 0.69802 (2) | 0.11426 (2) | 0.01809 (5) | |
Br2 | 0.09621 (2) | 0.58825 (2) | 0.34885 (2) | 0.01872 (5) | |
N1 | 0.54040 (19) | 0.38619 (10) | 0.23392 (9) | 0.0157 (3) | |
C1 | 0.5310 (2) | 0.34004 (13) | 0.16231 (11) | 0.0193 (4) | |
H1 | 0.470042 | 0.279632 | 0.153665 | 0.023* | |
C2 | 0.6074 (2) | 0.37819 (13) | 0.10161 (11) | 0.0190 (4) | |
H2 | 0.598713 | 0.344145 | 0.051717 | 0.023* | |
C3 | 0.6973 (2) | 0.46646 (13) | 0.1128 (1) | 0.0164 (3) | |
C4 | 0.7082 (2) | 0.51161 (13) | 0.18795 (10) | 0.0159 (3) | |
H4 | 0.771186 | 0.571265 | 0.198231 | 0.019* | |
C5 | 0.6300 (2) | 0.47175 (12) | 0.24753 (10) | 0.0140 (3) | |
C6 | 0.4467 (2) | 0.34092 (13) | 0.29478 (11) | 0.0188 (4) | |
H6A | 0.337285 | 0.307919 | 0.266189 | 0.023* | |
H6B | 0.410854 | 0.392247 | 0.329762 | 0.023* | |
C7 | 0.5666 (2) | 0.26732 (13) | 0.34768 (12) | 0.0215 (4) | |
H7B | 0.489315 | 0.219545 | 0.368381 | 0.026* | |
H7A | 0.635324 | 0.231572 | 0.312750 | 0.026* | |
C8 | 0.7795 (3) | 0.51217 (14) | 0.04805 (11) | 0.0232 (4) | |
H8A | 0.750594 | 0.473388 | −0.001783 | 0.035* | |
H8B | 0.909326 | 0.514930 | 0.066178 | 0.035* | |
H8C | 0.732611 | 0.578163 | 0.037298 | 0.035* | |
N1' | 0.72247 (18) | 0.4864 (1) | 0.39609 (8) | 0.0136 (3) | |
C1' | 0.7337 (2) | 0.53707 (13) | 0.46545 (10) | 0.0172 (4) | |
H1' | 0.792782 | 0.508916 | 0.515149 | 0.021* | |
C2' | 0.6619 (2) | 0.62861 (13) | 0.46625 (10) | 0.0170 (3) | |
H2' | 0.673762 | 0.663389 | 0.515955 | 0.020* | |
C3' | 0.5719 (2) | 0.67031 (13) | 0.39448 (11) | 0.0161 (3) | |
C4' | 0.5608 (2) | 0.61627 (12) | 0.32318 (10) | 0.0154 (3) | |
H4' | 0.500590 | 0.642672 | 0.272967 | 0.018* | |
C5' | 0.6360 (2) | 0.52515 (12) | 0.32479 (10) | 0.0135 (3) | |
C6' | 0.8162 (2) | 0.39082 (12) | 0.40077 (11) | 0.0169 (4) | |
H6A' | 0.925433 | 0.393784 | 0.443492 | 0.020* | |
H6B' | 0.852567 | 0.377516 | 0.348290 | 0.020* | |
C7' | 0.6976 (2) | 0.30844 (13) | 0.41992 (11) | 0.0198 (4) | |
H7A' | 0.629120 | 0.332138 | 0.460449 | 0.024* | |
H7B' | 0.775237 | 0.254877 | 0.445511 | 0.024* | |
C8' | 0.4859 (2) | 0.76805 (13) | 0.39343 (12) | 0.0210 (4) | |
H8A' | 0.500384 | 0.803271 | 0.344334 | 0.031* | |
H8B' | 0.542276 | 0.804908 | 0.441597 | 0.031* | |
H8C' | 0.358509 | 0.760037 | 0.393689 | 0.031* | |
O1W | 0.1964 (2) | 0.49717 (11) | 0.17678 (9) | 0.0297 (3) | |
H1W | 0.240 (3) | 0.5445 (16) | 0.1598 (16) | 0.044* | |
H2W | 0.168 (3) | 0.5155 (19) | 0.2183 (13) | 0.044* |
U11 | U22 | U33 | U12 | U13 | U23 | |
Br1 | 0.01962 (9) | 0.02036 (9) | 0.01455 (8) | 0.00295 (7) | 0.00397 (6) | 0.00357 (7) |
Br2 | 0.01603 (9) | 0.01993 (9) | 0.01935 (9) | −0.00218 (7) | 0.00129 (6) | 0.00533 (7) |
N1 | 0.0134 (7) | 0.0157 (7) | 0.0178 (7) | −0.0010 (6) | 0.0022 (6) | −0.0013 (6) |
C1 | 0.0155 (8) | 0.0185 (9) | 0.0229 (9) | −0.0014 (7) | 0.0012 (7) | −0.0065 (7) |
C2 | 0.0166 (8) | 0.0215 (9) | 0.0181 (8) | 0.0020 (7) | 0.0012 (7) | −0.0056 (7) |
C3 | 0.0146 (8) | 0.0189 (9) | 0.0153 (8) | 0.0046 (7) | 0.0020 (6) | 0.0001 (7) |
C4 | 0.0158 (8) | 0.0140 (8) | 0.0173 (8) | 0.0006 (6) | 0.0017 (6) | 0.0005 (7) |
C5 | 0.0110 (7) | 0.0144 (8) | 0.0157 (8) | 0.0020 (6) | 0.0004 (6) | −0.0005 (7) |
C6 | 0.0147 (8) | 0.0205 (9) | 0.0220 (9) | −0.0043 (7) | 0.0054 (7) | 0.0003 (7) |
C7 | 0.0199 (9) | 0.0166 (9) | 0.0288 (10) | −0.0027 (7) | 0.0064 (8) | 0.0033 (8) |
C8 | 0.028 (1) | 0.0254 (10) | 0.0170 (8) | 0.0006 (8) | 0.0064 (7) | 0.0000 (8) |
N1' | 0.0117 (7) | 0.0138 (7) | 0.0148 (7) | 0.0000 (5) | 0.0018 (5) | 0.0018 (6) |
C1' | 0.0135 (8) | 0.0234 (9) | 0.0138 (8) | −0.0030 (7) | 0.0005 (6) | 0.0008 (7) |
C2' | 0.0153 (8) | 0.0218 (9) | 0.0142 (8) | −0.0034 (7) | 0.0037 (6) | −0.0048 (7) |
C3' | 0.0111 (8) | 0.0164 (8) | 0.0213 (9) | −0.0035 (6) | 0.0045 (7) | −0.0017 (7) |
C4' | 0.0130 (8) | 0.0175 (8) | 0.0153 (8) | −0.0009 (6) | 0.0017 (6) | 0.0013 (7) |
C5' | 0.0110 (7) | 0.0151 (8) | 0.0143 (8) | −0.0025 (6) | 0.0021 (6) | 0.0002 (7) |
C6' | 0.0125 (8) | 0.0157 (8) | 0.0213 (9) | 0.0027 (6) | 0.0006 (7) | 0.0032 (7) |
C7' | 0.0164 (8) | 0.0184 (9) | 0.0246 (9) | 0.0016 (7) | 0.0044 (7) | 0.0068 (7) |
C8' | 0.0194 (9) | 0.0172 (9) | 0.0266 (9) | −0.0003 (7) | 0.0053 (7) | −0.0036 (8) |
O1W | 0.0309 (8) | 0.0252 (8) | 0.0342 (8) | −0.0016 (6) | 0.0096 (6) | −0.0014 (7) |
N1—C1 | 1.348 (2) | N1'—C1' | 1.344 (2) |
N1—C5 | 1.359 (2) | N1'—C5' | 1.358 (2) |
N1—C6 | 1.491 (2) | N1'—C6' | 1.492 (2) |
C1—C2 | 1.372 (3) | C1'—C2' | 1.375 (2) |
C1—H1 | 0.9500 | C1'—H1' | 0.9500 |
C2—C3 | 1.390 (2) | C2'—C3' | 1.389 (2) |
C2—H2 | 0.9500 | C2'—H2' | 0.9500 |
C3—C4 | 1.393 (2) | C3'—C4' | 1.396 (2) |
C3—C8 | 1.494 (2) | C3'—C8' | 1.495 (2) |
C4—C5 | 1.374 (2) | C4'—C5' | 1.377 (2) |
C4—H4 | 0.9500 | C4'—H4' | 0.9500 |
C5—C5' | 1.482 (2) | C6'—C7' | 1.523 (2) |
C6—C7 | 1.528 (3) | C6'—H6A' | 0.9900 |
C6—H6A | 0.9900 | C6'—H6B' | 0.9900 |
C6—H6B | 0.9900 | C7'—H7A' | 0.9900 |
C7—C7' | 1.523 (3) | C7'—H7B' | 0.9900 |
C7—H7B | 0.9900 | C8'—H8A' | 0.9800 |
C7—H7A | 0.9900 | C8'—H8B' | 0.9800 |
C8—H8A | 0.9800 | C8'—H8C' | 0.9800 |
C8—H8B | 0.9800 | O1W—H1W | 0.809 (19) |
C8—H8C | 0.9800 | O1W—H2W | 0.807 (19) |
C1—N1—C5 | 119.74 (15) | C1'—N1'—C6' | 117.50 (14) |
C1—N1—C6 | 117.59 (15) | C5'—N1'—C6' | 122.62 (14) |
C5—N1—C6 | 122.66 (14) | N1'—C1'—C2' | 121.64 (16) |
N1—C1—C2 | 121.59 (17) | N1'—C1'—H1' | 119.2 |
N1—C1—H1 | 119.2 | C2'—C1'—H1' | 119.2 |
C2—C1—H1 | 119.2 | C1'—C2'—C3' | 120.09 (16) |
C1—C2—C3 | 120.29 (16) | C1'—C2'—H2' | 120.0 |
C1—C2—H2 | 119.9 | C3'—C2'—H2' | 120.0 |
C3—C2—H2 | 119.9 | C2'—C3'—C4' | 117.37 (16) |
C2—C3—C4 | 116.94 (16) | C2'—C3'—C8' | 121.61 (16) |
C2—C3—C8 | 122.41 (16) | C4'—C3'—C8' | 121.00 (16) |
C4—C3—C8 | 120.65 (16) | C5'—C4'—C3' | 120.79 (16) |
C5—C4—C3 | 121.45 (16) | C5'—C4'—H4' | 119.6 |
C5—C4—H4 | 119.3 | C3'—C4'—H4' | 119.6 |
C3—C4—H4 | 119.3 | N1'—C5'—C4' | 120.31 (15) |
N1—C5—C4 | 119.97 (15) | N1'—C5'—C5 | 120.15 (15) |
N1—C5—C5' | 120.37 (15) | C4'—C5'—C5 | 119.46 (15) |
C4—C5—C5' | 119.58 (15) | N1'—C6'—C7' | 111.60 (14) |
N1—C6—C7 | 111.16 (14) | N1'—C6'—H6A' | 109.3 |
N1—C6—H6A | 109.4 | C7'—C6'—H6A' | 109.3 |
C7—C6—H6A | 109.4 | N1'—C6'—H6B' | 109.3 |
N1—C6—H6B | 109.4 | C7'—C6'—H6B' | 109.3 |
C7—C6—H6B | 109.4 | H6A'—C6'—H6B' | 108.0 |
H6A—C6—H6B | 108.0 | C6'—C7'—C7 | 115.78 (15) |
C7'—C7—C6 | 116.31 (15) | C6'—C7'—H7A' | 108.3 |
C7'—C7—H7B | 108.2 | C7—C7'—H7A' | 108.3 |
C6—C7—H7B | 108.2 | C6'—C7'—H7B' | 108.3 |
C7'—C7—H7A | 108.2 | C7—C7'—H7B' | 108.3 |
C6—C7—H7A | 108.2 | H7A'—C7'—H7B' | 107.4 |
H7B—C7—H7A | 107.4 | C3'—C8'—H8A' | 109.5 |
C3—C8—H8A | 109.5 | C3'—C8'—H8B' | 109.5 |
C3—C8—H8B | 109.5 | H8A'—C8'—H8B' | 109.5 |
H8A—C8—H8B | 109.5 | C3'—C8'—H8C' | 109.5 |
C3—C8—H8C | 109.5 | H8A'—C8'—H8C' | 109.5 |
H8A—C8—H8C | 109.5 | H8B'—C8'—H8C' | 109.5 |
H8B—C8—H8C | 109.5 | H1W—O1W—H2W | 104 (3) |
C1'—N1'—C5' | 119.79 (15) | ||
C5—N1—C1—C2 | −1.2 (3) | C1'—C2'—C3'—C4' | −0.8 (2) |
C6—N1—C1—C2 | 177.51 (16) | C1'—C2'—C3'—C8' | 177.56 (16) |
N1—C1—C2—C3 | 0.0 (3) | C2'—C3'—C4'—C5' | 0.2 (2) |
C1—C2—C3—C4 | 1.3 (2) | C8'—C3'—C4'—C5' | −178.18 (16) |
C1—C2—C3—C8 | −178.70 (17) | C1'—N1'—C5'—C4' | 0.4 (2) |
C2—C3—C4—C5 | −1.5 (2) | C6'—N1'—C5'—C4' | −176.07 (15) |
C8—C3—C4—C5 | 178.50 (16) | C1'—N1'—C5'—C5 | 177.22 (15) |
C1—N1—C5—C4 | 1.0 (2) | C6'—N1'—C5'—C5 | 0.8 (2) |
C6—N1—C5—C4 | −177.65 (15) | C3'—C4'—C5'—N1' | 0.0 (2) |
C1—N1—C5—C5' | 177.79 (15) | C3'—C4'—C5'—C5 | −176.85 (15) |
C6—N1—C5—C5' | −0.8 (2) | N1—C5—C5'—N1' | 66.1 (2) |
C3—C4—C5—N1 | 0.4 (3) | C4—C5—C5'—N1' | −117.12 (18) |
C3—C4—C5—C5' | −176.45 (15) | N1—C5—C5'—C4' | −117.09 (18) |
C1—N1—C6—C7 | 87.25 (19) | C4—C5—C5'—C4' | 59.7 (2) |
C5—N1—C6—C7 | −94.09 (19) | C1'—N1'—C6'—C7' | 88.23 (18) |
N1—C6—C7—C7' | 83.16 (19) | C5'—N1'—C6'—C7' | −95.23 (19) |
C5'—N1'—C1'—C2' | −1.0 (2) | N1'—C6'—C7'—C7 | 82.48 (19) |
C6'—N1'—C1'—C2' | 175.61 (15) | C6—C7—C7'—C6' | −52.2 (2) |
N1'—C1'—C2'—C3' | 1.3 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
C1—H1···Br2i | 0.95 | 2.68 | 3.5929 (18) | 161 |
C2—H2···Br1ii | 0.95 | 2.86 | 3.7762 (18) | 161 |
C7—H7B···Br1i | 0.99 | 2.96 | 3.7700 (19) | 139 |
C1′—H1′···Br2iii | 0.95 | 2.64 | 3.5765 (17) | 170 |
C2′—H2′···Br1iv | 0.95 | 2.82 | 3.6285 (17) | 143 |
C4′—H4′···Br1 | 0.95 | 2.74 | 3.6735 (17) | 167 |
C7′—H7B′···Br1v | 0.99 | 3.04 | 3.6581 (18) | 122 |
O1W—H1W···Br1 | 0.81 (2) | 2.58 (2) | 3.3856 (15) | 177 (3) |
O1W—H2W···Br2 | 0.81 (2) | 2.56 (2) | 3.3670 (15) | 175 (3) |
Symmetry codes: (i) −x+1/2, y−1/2, −z+1/2; (ii) −x+1, −y+1, −z; (iii) −x+1, −y+1, −z+1; (iv) x+1/2, −y+3/2, z+1/2; (v) −x+3/2, y−1/2, −z+1/2. |
H···H | 57.0 |
H···Br | 26.2 |
H···C | 9.0 |
H···O | 4.7 |
C···Br | 1.7 |
N···Br | 1.1 |
C···C | 0.4 |
N···N | 0.0 |
O···O | 0.0 |
Br···Br | 0.0 |
Contact percentages were derived from Hirshfeld-surface fingerprint plots (Spackman & McKinnon, 2002; McKinnon et al., 2004) using CrystalExplorer 17.5 (Turner et al., 2017). Reciprocal contacts are included in the totals. The sum of all percentages in the table is 100.1% due to accumulation of rounding errors. |
Assignments | 13C (ppm) | 1H (ppm) | Couplings (Hz) |
C1/H1 | 146.25 | 8.99 | 3J(H1H2) 6.4 |
C2/H2 | 131.70 | 8.14 | 4J(H2H4) 1.4 |
C3 | 162.63 | ||
C4/H4 | 131.66 | 8.07 | |
C5 | 142.78 | ||
C6/H6A,H6B | 58.26 | H6A,6B 4.73, 4.03 | 2J(H6aH6B) 14.5, 3J(H6AH7A) 6.1, 3J(H6BH7B) 11.3 |
C7/H7A,H7B | 26.72 | H7A,7B 2.35, 2.05 | 2J(H7AH7B) 11.1 |
C8/H8 | 21.62 | 2.68 | |
N9 | 208.5 |
The errors were estimated to be ±0.02ppm, ± 0.002ppm, and ±0.3Hz, respectively, for the 13C chemical shifts, 1H chemical shifts, and J coupling constants. |
Acknowledgements
The D8 Venture diffractometer was funded by the NSF (MRI CHE1625732), and by the University of Kentucky.
Funding information
Funding for this research was provided by: NSF (grant No. CHE1625732 to Sean Parkin).
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