research communications
Reduced 3,4′-bipyrazoles carrying thiophene and thiazole substituents: structures of two intermediates and two products
aDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru-570 006, India, bDepartment of Studies in Chemistry, Mangalore University, Mangalagangotri, Mangalore-574 199, India, cInstitute of Materials Science, Darmstadt University of Technology, Alarich-Weiss-Strasse 2, D-64287 Darmstadt, Germany, and dSchool of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK
*Correspondence e-mail: yathirajan@hotmail.com
Cycloaddition reactions between 3-(5-aryloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(thiophen-2-yl)prop-2-en-1-ones and thiosemicarbazide leads to the formation of reduced 3,4′-bipyrazole-2-carbothioamides. Further cycloaddition of these intermediates with either diethyl acetylenedicarboxylate or 4-bromophenacyl bromide leads to reduced 3,4′-bipyrazoles carrying oxothiazole or thiazole substituents, respectively. The structures of two representative intermediates and two representative products established unambiguously the regiochemistry of the cycloaddition reactions. The molecules of 3′-methyl-5′-(2-methylphenoxy)-1′-phenyl-5-(thiophen-2-yl)-3,4-dihydro-1′H,2H-3,4′-bipyrazole-2-carbothioamide, C25H23N5OS2 (Ia), are linked by N—H⋯N hydrogen bonds to form simple C(8) chains. The analogous compound 5′-(2,4-dichlorophenoxy)-3′-methyl-1′-phenyl-5-(thiophen-2-yl)-3,4-dihydro-1′H,2H-3,4′-bipyrazole-2-carbothioamide hemihydrate crystallizes as a hemihydrate, C24H19Cl2N5OS2·0.5H2O (Ib), and the independent components are linked into a chain of spiro-fused R44(20) rings by a combination of O—H⋯N and N—H⋯O hydrogen bonds. In the structure of ethyl (Z)-2-{2-[3′-methyl-1′-phenyl-5-(thiophen-2-yl)-5′-(2-methylphenoxy)-3,4-dihydro-1′H,2H-3,4′-bipyrazole-2-yl]-4-oxo-4,5-dihydrothiazol-5-ylidene}acetate, C31H27N5O4S2 (II), inversion-related pairs of molecules are linked by paired C—H⋯π(arene) hydrogen bonds to form cyclic centrosymmetric dimers, but there are no direction-specific intermolecular interactions in 4-(4-bromophenyl)-2-[5′-(2,4-dichlorophenoxy)-3′-methyl-1′-phenyl-5-(thiophen-2-yl)-3,4-dihydro-1′H,2H-3,4′-bipyrazole-2-yl]-4-thiazole, C32H22BrCl2N5OS2 (III). Comparisons are made with the structures of some related compounds.
1. Chemical context
et al., 2008; Isloor et al., 2009; Vijesh et al., 2013) and analgesic and anti-inflammatory activity (Girisha et al., 2010; Isloor et al., 2010; Vijesh et al., 2013). It has also been found that the incorporation of a thiazole or thiazolone substituent often leads to enhanced activity (Sulthana et al., 2015; Havrylyuk et al., 2016), as does the incorporation of a thiophene substituent (Rostom et al., 2009; Bondock et al., 2010). In this connection, a procedure has recently been developed (Manju et al., 2019) for the synthesis of reduced 3,4′-bipyrazoles incorporating other heterocyclic units such as thiazole, thiazoline and thiophene as integral components. In brief, condensation of a 5-aryloxy-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde with 2-acetylthiophene gives the corresponding chalcone (Shaibah et al., 2020); of this type can undergo cyclocondensation reactions with semicabazide to provide the intermediate carbothioamides of type (I) (see Scheme). Further condensation of type (I) intermediates with diethyl acetylenedicarboxylate or with 4-bromophenacyl bromide gave the oxothiazolylidene ester (II) or the thiazole (III), respectively (see Scheme). Although the NMR spectra of the intermediates (I) and the products (II) and (III) contained all of the expected signals, it was not possible to establish uniquely from these data the regiochemistry of the cycloaddition reactions leading to their formation, and accordingly we have determined the structures of two representative intermediates (Ia) and (Ib) (Figs. 1 and 2) and of two representative products (II) (Fig. 3) and (III) (Fig. 4).
containing the pyrazole unit have been found to exhibit a wide range of biological activities, including antibacterial and antifungal activity (Rai2. Structural commentary
Although compounds (Ia), (Ib), (II) and (III) were all crystallized under identical conditions, compound (Ib) crystallized as a hemihydrate, in which the water molecules lies across a twofold rotation axis, while the other three compounds all crystallized in solvent-free form. In each compound, the thiophene substituent is disordered over two sets of atomic sites (Section 6), whose relationship approximately corresponds to a rotation of 180° about the bond C45—C452 (Figs. 1–4). That the cyclocondensation reactions between the chalcone precursors and thiosemicarbazide lead to the formation of new pyrazole rings indicates that it is the two N atoms of the hydrazine unit in thiosemicarbazide that participate in this reaction step. If the participants had been the two N atoms either side of the thiocarbonyl unit, then the products would have been the regioisomers of type (A), containing a newly formed reduced pyrimidine ring in place of the pyrazole ring actually observed (Fig. 5). Similarly, in the cyclocondensation reactions between the carbothioamides (I) and either diethyl acetylenedicarboxylate or 4-bromophenacyl bromide to form (II) and (III), respectively, alternative regiochemistry is possible in each case, to yield products of types (B) and (C), respectively (Fig. 5). The X-ray analyses reported here have confirmed that the single products formed in each of these cyclocondensation reactions (Manju et al., 2019) have structures of types (I)–(III), as opposed to the possible alternative isomers (A)–(C).
3. Supramolecular features
The supramolecular assembly of compound (Ia) is extremely simple: a single N—H⋯N hydrogen bond (Table 1) links molecules that are related by translation into a C(8) (Etter, 1990; Etter et al., 1990; Bernstein et al., 1995) chain running parallel to the [100] direction (Fig. 6), but there are no direction-specific interactions between adjacent chains.
Compound (Ib) is a hemihydrate in which the water component lies across a twofold rotation axis, and the supramolecular aggregation is more complex than that in (Ia). There is an O—H⋯N hydrogen bond within the selected (Table 1), and pairs of inversion-related bimolecular units of this type are linked by paired N—H⋯O hydrogen bonds to form an R44(20) ring. Propagation of this motif by the action of the twofold rotation axes generates a chain of spiro-fused R44(20) rings running parallel to the [001] direction, in which the centrosymmetric rings are centred at (0.5, 0.5, 0.5n) where n represents an integer (Fig. 7). Within this chain the water molecules, which act as double donors in O—H⋯N hydrogen bonds and double acceptors in N—H⋯O hydrogen bonds, are the points of fusion between adjacent rings (Fig. 7).
There are three short intermolecular contacts in the structure of compound (II). That involving atom C13 (Table 1) has a very small D—H⋯A angle, and so is unlikely to be structurally significant (Wood et al., 2009), while that involving atom C553 applies only to the minor disorder component, and is absent for the majority of the molecules. The only possible significant interaction is thus that involving atom C54, which links inversion-related pairs of molecules to form a cyclic centrosymmetric motif (Fig. 8). There are no significant hydrogen bonds of any type in the structure of compound (III).
4. Database survey
Structures have been reported recently for a number of compounds related to those reported here, including precursors and intermediates in the synthetic pathways to compounds (I)–(III). The structures of five examples of 5-aryloxy-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehydes have been reported (Shahani et al., 2011; Vinutha et al., 2014; Glidewell et al., 2019; Kiran Kumar et al., 2019), as have those (Shaibah et al., 2020) of two isostructural derived from two such carbaldehydes by condensation reactions with 2-acetylthiophene, in each of which the thiophene unit shows the same type of disorder as observed here in compounds (Ia), (Ib), (II) and (III). Structures have also been reported (Cuartas et al., 2017; Kiran Kumar et al., 2019) for several reduced 3,4′-bipyrazoles formed by cyclocondensation reactions between and hydrazine followed by N-acetylation. However, the only structure reported to date of a product in which the 3,4′-bipyrazole unit is embedded within a group of other cyclic substituents, as in (I)–(III) is that for the methyl ester analogue of (II) (Manju et al., 2019). The original report on this compound provided no crystallographic information other than a molecular structure plot. However, the deposited (CCDC deposition No. 1588961) shows that the reflection data have been subjected to the SQUEEZE procedure (Spek, 2015), although this is not mentioned in the original report. The also shows two sites for the O atom of the aryloxy unit, ca 1.28 Å apart with occupancies of 0.843 (6) and 0.157 (6) and involving some unexpected geometrical features, although all other atoms are reported as being fully ordered. Hence this structure is unlikely to be entirely correct.
5. Synthesis and crystallization
Samples of compounds (Ia), (Ib), (II) and (III) were prepared using the methods previously reported (Manju et al., 2019). Crystals suitable for single-crystal X-ray diffraction were grown by slow evaporation, at ambient temperature and in the presence of air, of solutions in a mixture of ethanol and N,N-dimethylformamide (initial composition 3:1, v/v).
6. Refinement
Crystal data, data collection and structure . Several bad outlier reflections were omitted from the refinements. i.e. for (Ia) (,,18); for (Ic) (1,1,1), (14,0,0), (,0,6), (,1,19), (,9,7) and (,3,2); and for (II) (,,2) and (0,5,13). All H atoms, apart from those in the minor disorder components, were located in difference maps. The H atoms bonded to C atoms were then treated as riding atoms in geometrically idealized positions with C—H distances of 0.93 Å (alkenyl, aromatic and thienyl), 0.96 Å (CH3), 0.97 Å (CH2) or 0.98 Å (aliphatic C—H), and with Uiso(H) = kUeq(C), where k = 1.5 for the methyl groups, which were permitted to rotate but not to tilt, and 1.2 for all other H atoms bonded to C atoms. For the H atoms bonded to N or O atoms, the atomic coordinates were refined with Uiso(H) = 1.2Ueq(N) or 1.5Ueq(O), giving the N—H and O—H distances shown in Table 1. For the minor disorder components, the bonded distances and the 1,3 non-bonded distances were restrained to be the same as the corresponding distances in the major disorder components, subject to s.u. values of 0.01 and 0.02 Å, respectively. In addition, the anisotropic displacement parameters associated with pairs of atomic sites occupying essentially the same regions of physical space were constrained to be equal. Subject to these conditions, the occupancies, in the crystals selected for data collection, of the disordered thienyl units refined to 0.866 (3) and 0.134 (3) in (Ia), 0.951 (3) and 0.049 (3) in (Ib), 0.768 (6) and 0.232 (6) in (II), and 0.947 (4) and 0.053 (4) in (III).
details are summarized in Table 2
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Supporting information
https://doi.org/10.1107/S2056989021002310/dx2035sup1.cif
contains datablocks global, Ia, Ib, II, III. DOI:Structure factors: contains datablock Ia. DOI: https://doi.org/10.1107/S2056989021002310/dx2035Iasup2.hkl
Structure factors: contains datablock Ib. DOI: https://doi.org/10.1107/S2056989021002310/dx2035Ibsup3.hkl
Structure factors: contains datablock II. DOI: https://doi.org/10.1107/S2056989021002310/dx2035IIsup4.hkl
Structure factors: contains datablock III. DOI: https://doi.org/10.1107/S2056989021002310/dx2035IIIsup5.hkl
Supporting information file. DOI: https://doi.org/10.1107/S2056989021002310/dx2035Iasup6.cml
Supporting information file. DOI: https://doi.org/10.1107/S2056989021002310/dx2035Ibsup7.cml
Supporting information file. DOI: https://doi.org/10.1107/S2056989021002310/dx2035IIsup8.cml
For all structures, data collection: CrysAlis CCD (Oxford Diffraction, 2009); cell
CrysAlis RED (Oxford Diffraction, 2009); data reduction: CrysAlis RED (Oxford Diffraction, 2009); program(s) used to solve structure: SHELXT (Sheldrick, 2015a); program(s) used to refine structure: SHELXL2014 (Sheldrick, 2015b); molecular graphics: PLATON (Spek, 2020); software used to prepare material for publication: SHELXL2014 (Sheldrick, 2015b) and PLATON (Spek, 2020).C25H23N5OS2 | Z = 2 |
Mr = 473.60 | F(000) = 496 |
Triclinic, P1 | Dx = 1.324 Mg m−3 |
a = 8.6269 (7) Å | Mo Kα radiation, λ = 0.71073 Å |
b = 9.8418 (9) Å | Cell parameters from 5098 reflections |
c = 14.900 (1) Å | θ = 2.9–27.9° |
α = 90.588 (7)° | µ = 0.25 mm−1 |
β = 106.162 (8)° | T = 296 K |
γ = 101.441 (7)° | Needle, yellow |
V = 1188.05 (17) Å3 | 0.36 × 0.12 × 0.04 mm |
Oxford Diffraction Xcalibur with Sapphire CCD detector diffractometer | 4898 independent reflections |
Radiation source: Enhance (Mo) X-ray Source | 2524 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.030 |
ω scans | θmax = 26.6°, θmin = 2.9° |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009) | h = −10→9 |
Tmin = 0.949, Tmax = 0.990 | k = −10→12 |
8241 measured reflections | l = −16→18 |
Refinement on F2 | Primary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: mixed |
R[F2 > 2σ(F2)] = 0.056 | H atoms treated by a mixture of independent and constrained refinement |
wR(F2) = 0.112 | w = 1/[σ2(Fo2) + (0.038P)2 + 0.0763P] where P = (Fo2 + 2Fc2)/3 |
S = 1.03 | (Δ/σ)max < 0.001 |
4898 reflections | Δρmax = 0.18 e Å−3 |
319 parameters | Δρmin = −0.18 e Å−3 |
10 restraints |
Experimental. CrysAlis RED, Oxford Diffraction Ltd., 2009 Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
N1 | −0.0795 (2) | 0.6663 (2) | 0.30851 (14) | 0.0406 (6) | |
N2 | −0.2192 (2) | 0.6179 (2) | 0.23518 (15) | 0.0451 (6) | |
C3 | −0.1670 (3) | 0.6245 (3) | 0.15926 (18) | 0.0421 (7) | |
C4 | 0.0047 (3) | 0.6737 (3) | 0.18050 (17) | 0.0384 (7) | |
C5 | 0.0541 (3) | 0.6994 (3) | 0.27513 (17) | 0.0384 (7) | |
C11 | −0.0885 (3) | 0.6605 (3) | 0.40219 (18) | 0.0445 (7) | |
C12 | 0.0024 (3) | 0.7654 (4) | 0.4690 (2) | 0.0625 (9) | |
H12 | 0.0687 | 0.8426 | 0.4532 | 0.075* | |
C13 | −0.0067 (4) | 0.7541 (5) | 0.5603 (2) | 0.0816 (12) | |
H13 | 0.0563 | 0.8232 | 0.6063 | 0.098* | |
C14 | −0.1073 (5) | 0.6421 (5) | 0.5835 (2) | 0.0838 (12) | |
H14 | −0.1123 | 0.6354 | 0.6448 | 0.101* | |
C15 | −0.2004 (4) | 0.5399 (4) | 0.5157 (3) | 0.0757 (11) | |
H15 | −0.2704 | 0.4648 | 0.5310 | 0.091* | |
C16 | −0.1904 (3) | 0.5484 (3) | 0.4250 (2) | 0.0565 (8) | |
H16 | −0.2524 | 0.4784 | 0.3793 | 0.068* | |
C31 | −0.2869 (3) | 0.5831 (3) | 0.06491 (18) | 0.0615 (9) | |
H31A | −0.2770 | 0.6581 | 0.0249 | 0.092* | |
H31B | −0.3970 | 0.5616 | 0.0707 | 0.092* | |
H31C | −0.2637 | 0.5027 | 0.0384 | 0.092* | |
N41 | 0.4015 (2) | 0.7247 (3) | 0.16104 (14) | 0.0415 (6) | |
N42 | 0.2565 (2) | 0.6253 (2) | 0.14876 (14) | 0.0393 (6) | |
C43 | 0.1056 (3) | 0.6826 (3) | 0.11269 (17) | 0.0412 (7) | |
H43 | 0.0379 | 0.6306 | 0.0538 | 0.049* | |
C44 | 0.1805 (3) | 0.8295 (3) | 0.09133 (18) | 0.0496 (8) | |
H44A | 0.1515 | 0.8403 | 0.0244 | 0.060* | |
H44B | 0.1441 | 0.8997 | 0.1218 | 0.060* | |
C45 | 0.3626 (3) | 0.8383 (3) | 0.13106 (18) | 0.0418 (7) | |
S421 | 0.09307 (9) | 0.36681 (8) | 0.14413 (5) | 0.0559 (3) | |
C422 | 0.2638 (3) | 0.4938 (3) | 0.16724 (17) | 0.0408 (7) | |
N423 | 0.4148 (3) | 0.4679 (3) | 0.20351 (18) | 0.0538 (7) | |
H42A | 0.506 (3) | 0.539 (3) | 0.2180 (18) | 0.065* | |
H42B | 0.426 (3) | 0.380 (3) | 0.2139 (19) | 0.065* | |
S451 | 0.69257 (13) | 0.96287 (15) | 0.18083 (12) | 0.0769 (5) | 0.866 (3) |
C452 | 0.4879 (3) | 0.9623 (3) | 0.13580 (19) | 0.0515 (8) | 0.866 (3) |
C453 | 0.4652 (18) | 1.0876 (10) | 0.1098 (14) | 0.0769 (15) | 0.866 (3) |
H453 | 0.3615 | 1.1067 | 0.0830 | 0.092* | 0.866 (3) |
C454 | 0.6146 (9) | 1.1897 (8) | 0.1270 (14) | 0.104 (2) | 0.866 (3) |
H454 | 0.6204 | 1.2821 | 0.1127 | 0.125* | 0.866 (3) |
C455 | 0.7456 (8) | 1.1343 (6) | 0.1666 (8) | 0.099 (2) | 0.866 (3) |
H455 | 0.8539 | 1.1848 | 0.1844 | 0.119* | 0.866 (3) |
S551 | 0.456 (3) | 1.1213 (19) | 0.104 (3) | 0.0769 (15) | 0.134 (3) |
C552 | 0.4879 (3) | 0.9623 (3) | 0.13580 (19) | 0.0515 (8) | 0.134 (3) |
C553 | 0.6476 (19) | 0.960 (4) | 0.159 (4) | 0.0769 (5) | 0.134 (3) |
H553 | 0.6877 | 0.8792 | 0.1740 | 0.092* | 0.134 (3) |
C554 | 0.751 (3) | 1.092 (4) | 0.158 (6) | 0.099 (2) | 0.134 (3) |
H554 | 0.8660 | 1.1083 | 0.1735 | 0.119* | 0.134 (3) |
C555 | 0.661 (4) | 1.189 (4) | 0.133 (10) | 0.104 (2) | 0.134 (3) |
H555 | 0.7062 | 1.2828 | 0.1317 | 0.125* | 0.134 (3) |
O51 | 0.20838 (18) | 0.73742 (19) | 0.33641 (11) | 0.0434 (5) | |
C51 | 0.2920 (3) | 0.8764 (3) | 0.34104 (17) | 0.0432 (7) | |
C52 | 0.4615 (3) | 0.8993 (4) | 0.37778 (18) | 0.0535 (8) | |
C53 | 0.5473 (5) | 1.0365 (5) | 0.3857 (2) | 0.0833 (13) | |
H53 | 0.6615 | 1.0564 | 0.4102 | 0.100* | |
C54 | 0.4682 (7) | 1.1423 (5) | 0.3583 (3) | 0.1011 (15) | |
H54 | 0.5291 | 1.2330 | 0.3649 | 0.121* | |
C55 | 0.3006 (6) | 1.1174 (4) | 0.3213 (3) | 0.0882 (12) | |
H55 | 0.2478 | 1.1901 | 0.3018 | 0.106* | |
C56 | 0.2104 (4) | 0.9822 (4) | 0.3131 (2) | 0.0626 (9) | |
H56 | 0.0961 | 0.9634 | 0.2889 | 0.075* | |
C57 | 0.5475 (4) | 0.7841 (4) | 0.4051 (2) | 0.0804 (11) | |
H57A | 0.6602 | 0.8211 | 0.4398 | 0.121* | |
H57B | 0.5441 | 0.7310 | 0.3500 | 0.121* | |
H57C | 0.4940 | 0.7253 | 0.4435 | 0.121* |
U11 | U22 | U33 | U12 | U13 | U23 | |
N1 | 0.0280 (12) | 0.0587 (17) | 0.0333 (13) | 0.0070 (10) | 0.0073 (10) | 0.0036 (11) |
N2 | 0.0269 (12) | 0.0642 (18) | 0.0403 (13) | 0.0050 (11) | 0.0063 (11) | 0.0041 (11) |
C3 | 0.0276 (14) | 0.057 (2) | 0.0382 (16) | 0.0036 (12) | 0.0073 (12) | 0.0040 (13) |
C4 | 0.0265 (14) | 0.0520 (19) | 0.0335 (16) | 0.0026 (12) | 0.0072 (12) | 0.0031 (13) |
C5 | 0.0237 (14) | 0.0491 (19) | 0.0400 (16) | 0.0047 (12) | 0.0073 (12) | 0.0048 (13) |
C11 | 0.0319 (15) | 0.070 (2) | 0.0363 (17) | 0.0195 (14) | 0.0112 (13) | 0.0073 (15) |
C12 | 0.0516 (19) | 0.089 (3) | 0.049 (2) | 0.0129 (17) | 0.0179 (16) | −0.0042 (18) |
C13 | 0.071 (2) | 0.129 (4) | 0.049 (2) | 0.029 (2) | 0.0175 (19) | −0.011 (2) |
C14 | 0.085 (3) | 0.143 (4) | 0.047 (2) | 0.059 (3) | 0.031 (2) | 0.023 (2) |
C15 | 0.073 (2) | 0.105 (3) | 0.069 (2) | 0.037 (2) | 0.038 (2) | 0.039 (2) |
C16 | 0.0508 (18) | 0.072 (2) | 0.053 (2) | 0.0205 (16) | 0.0208 (15) | 0.0169 (16) |
C31 | 0.0324 (16) | 0.095 (3) | 0.0440 (18) | −0.0081 (15) | 0.0050 (14) | −0.0017 (17) |
N41 | 0.0288 (12) | 0.0448 (16) | 0.0471 (14) | −0.0054 (11) | 0.0141 (10) | −0.0002 (12) |
N42 | 0.0259 (12) | 0.0429 (16) | 0.0468 (14) | −0.0018 (10) | 0.0132 (10) | 0.0027 (11) |
C43 | 0.0313 (15) | 0.054 (2) | 0.0342 (15) | 0.0018 (13) | 0.0073 (12) | 0.0049 (13) |
C44 | 0.0437 (17) | 0.060 (2) | 0.0465 (17) | 0.0070 (14) | 0.0172 (14) | 0.0109 (15) |
C45 | 0.0369 (16) | 0.049 (2) | 0.0376 (16) | −0.0023 (14) | 0.0154 (13) | 0.0021 (14) |
S421 | 0.0477 (5) | 0.0563 (6) | 0.0525 (5) | −0.0151 (4) | 0.0143 (4) | 0.0049 (4) |
C422 | 0.0387 (17) | 0.049 (2) | 0.0340 (16) | −0.0004 (14) | 0.0155 (13) | 0.0007 (13) |
N423 | 0.0410 (15) | 0.0452 (18) | 0.0733 (18) | 0.0051 (13) | 0.0161 (14) | 0.0093 (15) |
S451 | 0.0458 (7) | 0.0803 (9) | 0.0897 (12) | −0.0215 (6) | 0.0194 (7) | 0.0077 (7) |
C452 | 0.0507 (18) | 0.050 (2) | 0.0530 (19) | −0.0039 (15) | 0.0241 (15) | 0.0042 (15) |
C453 | 0.095 (3) | 0.050 (5) | 0.095 (3) | 0.014 (4) | 0.041 (2) | 0.022 (5) |
C454 | 0.144 (6) | 0.050 (3) | 0.120 (5) | −0.023 (4) | 0.071 (7) | 0.013 (3) |
C455 | 0.097 (3) | 0.076 (5) | 0.106 (4) | −0.048 (3) | 0.046 (3) | −0.013 (5) |
S551 | 0.095 (3) | 0.050 (5) | 0.095 (3) | 0.014 (4) | 0.041 (2) | 0.022 (5) |
C552 | 0.0507 (18) | 0.050 (2) | 0.0530 (19) | −0.0039 (15) | 0.0241 (15) | 0.0042 (15) |
C553 | 0.0458 (7) | 0.0803 (9) | 0.0897 (12) | −0.0215 (6) | 0.0194 (7) | 0.0077 (7) |
C554 | 0.097 (3) | 0.076 (5) | 0.106 (4) | −0.048 (3) | 0.046 (3) | −0.013 (5) |
C555 | 0.144 (6) | 0.050 (3) | 0.120 (5) | −0.023 (4) | 0.071 (7) | 0.013 (3) |
O51 | 0.0265 (10) | 0.0521 (13) | 0.0445 (11) | 0.0054 (8) | 0.0009 (8) | 0.0032 (9) |
C51 | 0.0373 (16) | 0.050 (2) | 0.0386 (16) | 0.0002 (14) | 0.0115 (13) | −0.0033 (14) |
C52 | 0.0380 (17) | 0.075 (3) | 0.0406 (17) | 0.0016 (16) | 0.0073 (14) | −0.0046 (16) |
C53 | 0.064 (2) | 0.100 (4) | 0.065 (2) | −0.028 (2) | 0.0160 (19) | −0.015 (2) |
C54 | 0.129 (4) | 0.073 (4) | 0.085 (3) | −0.032 (3) | 0.043 (3) | −0.017 (3) |
C55 | 0.137 (4) | 0.054 (3) | 0.083 (3) | 0.018 (3) | 0.048 (3) | 0.004 (2) |
C56 | 0.069 (2) | 0.057 (3) | 0.066 (2) | 0.0164 (19) | 0.0243 (18) | 0.0042 (18) |
C57 | 0.0410 (19) | 0.119 (4) | 0.072 (2) | 0.018 (2) | 0.0016 (17) | 0.001 (2) |
N1—C5 | 1.362 (3) | S421—C422 | 1.682 (3) |
N1—N2 | 1.379 (2) | C422—N423 | 1.341 (3) |
N1—C11 | 1.421 (3) | N423—H42A | 0.91 (3) |
N2—C3 | 1.326 (3) | N423—H42B | 0.90 (3) |
C3—C4 | 1.407 (3) | S451—C455 | 1.690 (6) |
C3—C31 | 1.491 (3) | S451—C452 | 1.704 (3) |
C4—C5 | 1.360 (3) | C452—C453 | 1.331 (8) |
C4—C43 | 1.499 (3) | C453—C454 | 1.426 (13) |
C5—O51 | 1.366 (3) | C453—H453 | 0.9300 |
C11—C12 | 1.376 (4) | C454—C455 | 1.343 (7) |
C11—C16 | 1.376 (4) | C454—H454 | 0.9300 |
C12—C13 | 1.389 (4) | C455—H455 | 0.9300 |
C12—H12 | 0.9300 | S551—C555 | 1.690 (12) |
C13—C14 | 1.372 (5) | C553—C554 | 1.428 (16) |
C13—H13 | 0.9300 | C553—H553 | 0.9300 |
C14—C15 | 1.372 (5) | C554—C555 | 1.344 (12) |
C14—H14 | 0.9300 | C554—H554 | 0.9300 |
C15—C16 | 1.382 (4) | C555—H555 | 0.9300 |
C15—H15 | 0.9300 | O51—C51 | 1.406 (3) |
C16—H16 | 0.9300 | C51—C56 | 1.374 (4) |
C31—H31A | 0.9600 | C51—C52 | 1.382 (4) |
C31—H31B | 0.9600 | C52—C53 | 1.392 (5) |
C31—H31C | 0.9600 | C52—C57 | 1.475 (4) |
N41—C45 | 1.280 (3) | C53—C54 | 1.361 (5) |
N41—N42 | 1.392 (3) | C53—H53 | 0.9300 |
N42—C422 | 1.336 (3) | C54—C55 | 1.366 (5) |
N42—C43 | 1.487 (3) | C54—H54 | 0.9300 |
C43—C44 | 1.537 (3) | C55—C56 | 1.387 (4) |
C43—H43 | 0.9800 | C55—H55 | 0.9300 |
C44—C45 | 1.501 (3) | C56—H56 | 0.9300 |
C44—H44A | 0.9700 | C57—H57A | 0.9600 |
C44—H44B | 0.9700 | C57—H57B | 0.9600 |
C45—C452 | 1.447 (4) | C57—H57C | 0.9600 |
C5—N1—N2 | 109.56 (19) | N41—C45—C44 | 114.4 (2) |
C5—N1—C11 | 130.2 (2) | C452—C45—C44 | 124.5 (3) |
N2—N1—C11 | 119.8 (2) | N42—C422—N423 | 116.4 (2) |
C3—N2—N1 | 105.00 (18) | N42—C422—S421 | 121.8 (2) |
N2—C3—C4 | 112.4 (2) | N423—C422—S421 | 121.7 (2) |
N2—C3—C31 | 120.2 (2) | C422—N423—H42A | 120.3 (18) |
C4—C3—C31 | 127.4 (2) | C422—N423—H42B | 119.2 (18) |
C5—C4—C3 | 103.8 (2) | H42A—N423—H42B | 121 (3) |
C5—C4—C43 | 129.7 (2) | C455—S451—C452 | 91.8 (3) |
C3—C4—C43 | 126.3 (2) | C453—C452—C45 | 127.5 (7) |
C4—C5—N1 | 109.2 (2) | C453—C452—S451 | 111.0 (6) |
C4—C5—O51 | 130.8 (2) | C45—C452—S451 | 121.5 (3) |
N1—C5—O51 | 119.7 (2) | C452—C453—C454 | 113.8 (8) |
C12—C11—C16 | 120.5 (3) | C452—C453—H453 | 123.1 |
C12—C11—N1 | 120.6 (3) | C454—C453—H453 | 123.1 |
C16—C11—N1 | 118.8 (3) | C455—C454—C453 | 110.7 (6) |
C11—C12—C13 | 118.8 (3) | C455—C454—H454 | 124.7 |
C11—C12—H12 | 120.6 | C453—C454—H454 | 124.7 |
C13—C12—H12 | 120.6 | C454—C455—S451 | 112.7 (5) |
C14—C13—C12 | 120.8 (3) | C454—C455—H455 | 123.6 |
C14—C13—H13 | 119.6 | S451—C455—H455 | 123.6 |
C12—C13—H13 | 119.6 | C554—C553—H553 | 123.2 |
C15—C14—C13 | 119.8 (3) | C555—C554—C553 | 110.8 (13) |
C15—C14—H14 | 120.1 | C555—C554—H554 | 124.6 |
C13—C14—H14 | 120.1 | C553—C554—H554 | 124.6 |
C14—C15—C16 | 120.1 (3) | C554—C555—S551 | 112.2 (12) |
C14—C15—H15 | 119.9 | C554—C555—H555 | 123.9 |
C16—C15—H15 | 119.9 | S551—C555—H555 | 123.9 |
C11—C16—C15 | 119.9 (3) | C5—O51—C51 | 117.9 (2) |
C11—C16—H16 | 120.0 | C56—C51—C52 | 122.6 (3) |
C15—C16—H16 | 120.0 | C56—C51—O51 | 122.3 (2) |
C3—C31—H31A | 109.5 | C52—C51—O51 | 115.1 (3) |
C3—C31—H31B | 109.5 | C51—C52—C53 | 116.4 (3) |
H31A—C31—H31B | 109.5 | C51—C52—C57 | 121.8 (3) |
C3—C31—H31C | 109.5 | C53—C52—C57 | 121.7 (3) |
H31A—C31—H31C | 109.5 | C54—C53—C52 | 121.7 (4) |
H31B—C31—H31C | 109.5 | C54—C53—H53 | 119.2 |
C45—N41—N42 | 108.1 (2) | C52—C53—H53 | 119.2 |
C422—N42—N41 | 119.9 (2) | C53—C54—C55 | 121.0 (4) |
C422—N42—C43 | 127.2 (2) | C53—C54—H54 | 119.5 |
N41—N42—C43 | 112.9 (2) | C55—C54—H54 | 119.5 |
N42—C43—C4 | 112.3 (2) | C54—C55—C56 | 119.2 (4) |
N42—C43—C44 | 101.01 (19) | C54—C55—H55 | 120.4 |
C4—C43—C44 | 116.4 (2) | C56—C55—H55 | 120.4 |
N42—C43—H43 | 108.9 | C51—C56—C55 | 119.2 (3) |
C4—C43—H43 | 108.9 | C51—C56—H56 | 120.4 |
C44—C43—H43 | 108.9 | C55—C56—H56 | 120.4 |
C45—C44—C43 | 102.9 (2) | C52—C57—H57A | 109.5 |
C45—C44—H44A | 111.2 | C52—C57—H57B | 109.5 |
C43—C44—H44A | 111.2 | H57A—C57—H57B | 109.5 |
C45—C44—H44B | 111.2 | C52—C57—H57C | 109.5 |
C43—C44—H44B | 111.2 | H57A—C57—H57C | 109.5 |
H44A—C44—H44B | 109.1 | H57B—C57—H57C | 109.5 |
N41—C45—C452 | 121.1 (3) | ||
C5—N1—N2—C3 | −0.7 (3) | N42—C43—C44—C45 | −7.5 (2) |
C11—N1—N2—C3 | −173.9 (2) | C4—C43—C44—C45 | 114.3 (2) |
N1—N2—C3—C4 | 1.1 (3) | N42—N41—C45—C452 | 179.1 (2) |
N1—N2—C3—C31 | −178.5 (2) | N42—N41—C45—C44 | −1.3 (3) |
N2—C3—C4—C5 | −1.1 (3) | C43—C44—C45—N41 | 6.1 (3) |
C31—C3—C4—C5 | 178.5 (3) | C43—C44—C45—C452 | −174.4 (2) |
N2—C3—C4—C43 | 174.5 (3) | N41—N42—C422—N423 | 4.6 (3) |
C31—C3—C4—C43 | −5.8 (5) | C43—N42—C422—N423 | −177.0 (2) |
C3—C4—C5—N1 | 0.6 (3) | N41—N42—C422—S421 | −174.18 (16) |
C43—C4—C5—N1 | −174.8 (3) | C43—N42—C422—S421 | 4.2 (3) |
C3—C4—C5—O51 | 173.7 (3) | N41—C45—C452—C453 | −178.0 (11) |
C43—C4—C5—O51 | −1.7 (5) | C44—C45—C452—C453 | 2.5 (12) |
N2—N1—C5—C4 | 0.0 (3) | N41—C45—C452—S451 | 0.3 (4) |
C11—N1—C5—C4 | 172.3 (3) | C44—C45—C452—S451 | −179.2 (2) |
N2—N1—C5—O51 | −174.0 (2) | C455—S451—C452—C453 | 1.4 (10) |
C11—N1—C5—O51 | −1.7 (4) | C455—S451—C452—C45 | −177.2 (4) |
C5—N1—C11—C12 | 45.3 (4) | C45—C452—C453—C454 | 177.6 (11) |
N2—N1—C11—C12 | −143.1 (3) | S451—C452—C453—C454 | −0.9 (18) |
C5—N1—C11—C16 | −135.0 (3) | C452—C453—C454—C455 | 0 (2) |
N2—N1—C11—C16 | 36.6 (4) | C453—C454—C455—S451 | 1.4 (18) |
C16—C11—C12—C13 | 2.0 (5) | C452—S451—C455—C454 | −1.6 (11) |
N1—C11—C12—C13 | −178.3 (3) | C553—C554—C555—S551 | −4 (13) |
C11—C12—C13—C14 | −1.6 (5) | C4—C5—O51—C51 | 76.6 (4) |
C12—C13—C14—C15 | −0.1 (6) | N1—C5—O51—C51 | −110.9 (3) |
C13—C14—C15—C16 | 1.3 (5) | C5—O51—C51—C56 | 22.5 (3) |
C12—C11—C16—C15 | −0.8 (4) | C5—O51—C51—C52 | −158.9 (2) |
N1—C11—C16—C15 | 179.5 (3) | C56—C51—C52—C53 | 0.2 (4) |
C14—C15—C16—C11 | −0.9 (5) | O51—C51—C52—C53 | −178.3 (2) |
C45—N41—N42—C422 | 174.3 (2) | C56—C51—C52—C57 | −178.4 (3) |
C45—N41—N42—C43 | −4.4 (3) | O51—C51—C52—C57 | 3.1 (4) |
C422—N42—C43—C4 | 64.4 (3) | C51—C52—C53—C54 | −0.2 (5) |
N41—N42—C43—C4 | −117.0 (2) | C57—C52—C53—C54 | 178.4 (3) |
C422—N42—C43—C44 | −170.8 (2) | C52—C53—C54—C55 | −0.5 (6) |
N41—N42—C43—C44 | 7.7 (3) | C53—C54—C55—C56 | 1.1 (6) |
C5—C4—C43—N42 | 41.7 (4) | C52—C51—C56—C55 | 0.4 (4) |
C3—C4—C43—N42 | −132.8 (3) | O51—C51—C56—C55 | 178.8 (2) |
C5—C4—C43—C44 | −74.0 (4) | C54—C55—C56—C51 | −1.0 (5) |
C3—C4—C43—C44 | 111.5 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
N423—H42A···N2i | 0.92 (3) | 2.28 (3) | 3.111 (3) | 150 (2) |
N423—H42A···N41 | 0.92 (3) | 2.27 (3) | 2.628 (4) | 103 (2) |
Symmetry code: (i) x+1, y, z. |
2C24H19Cl2N5OS2·H2O | F(000) = 1108 |
Mr = 1074.94 | Dx = 1.456 Mg m−3 |
Monoclinic, P2/c | Mo Kα radiation, λ = 0.71073 Å |
a = 15.037 (1) Å | Cell parameters from 5307 reflections |
b = 8.4266 (6) Å | θ = 2.6–27.9° |
c = 19.471 (1) Å | µ = 0.47 mm−1 |
β = 96.246 (6)° | T = 296 K |
V = 2452.5 (3) Å3 | Needle, orange |
Z = 2 | 0.36 × 0.12 × 0.12 mm |
Oxford Diffraction Xcalibur with Sapphire CCD detector diffractometer | 5290 independent reflections |
Radiation source: Enhance (Mo) X-ray Source | 3075 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.033 |
ω scans | θmax = 27.6°, θmin = 2.6° |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009) | h = −19→13 |
Tmin = 0.922, Tmax = 0.946 | k = −10→10 |
10494 measured reflections | l = −25→25 |
Refinement on F2 | Primary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: mixed |
R[F2 > 2σ(F2)] = 0.046 | H atoms treated by a mixture of independent and constrained refinement |
wR(F2) = 0.097 | w = 1/[σ2(Fo2) + (0.0411P)2] where P = (Fo2 + 2Fc2)/3 |
S = 0.98 | (Δ/σ)max = 0.001 |
5290 reflections | Δρmax = 0.26 e Å−3 |
335 parameters | Δρmin = −0.30 e Å−3 |
10 restraints |
Experimental. CrysAlis RED, Oxford Diffraction Ltd., 2009 Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
N1 | 0.68939 (13) | 0.4363 (2) | 0.37947 (9) | 0.0343 (5) | |
N2 | 0.61354 (13) | 0.3752 (2) | 0.34400 (9) | 0.0356 (5) | |
C3 | 0.59656 (15) | 0.2419 (3) | 0.37692 (11) | 0.0318 (5) | |
C4 | 0.66061 (15) | 0.2149 (3) | 0.43422 (11) | 0.0296 (5) | |
C5 | 0.71767 (15) | 0.3404 (3) | 0.43322 (11) | 0.0308 (5) | |
C11 | 0.72930 (16) | 0.5768 (3) | 0.35564 (11) | 0.0354 (6) | |
C12 | 0.81789 (18) | 0.5775 (3) | 0.34460 (15) | 0.0602 (8) | |
H12 | 0.8535 | 0.4889 | 0.3557 | 0.072* | |
C13 | 0.8538 (2) | 0.7111 (4) | 0.31678 (17) | 0.0748 (10) | |
H13 | 0.9137 | 0.7127 | 0.3089 | 0.090* | |
C14 | 0.8006 (2) | 0.8415 (3) | 0.30086 (14) | 0.0580 (8) | |
H14 | 0.8244 | 0.9307 | 0.2815 | 0.070* | |
C15 | 0.7138 (2) | 0.8410 (3) | 0.31316 (13) | 0.0471 (7) | |
H15 | 0.6788 | 0.9306 | 0.3028 | 0.057* | |
C16 | 0.67667 (17) | 0.7089 (3) | 0.34090 (11) | 0.0384 (6) | |
H16 | 0.6170 | 0.7092 | 0.3495 | 0.046* | |
C31 | 0.51811 (17) | 0.1418 (3) | 0.35213 (13) | 0.0438 (6) | |
H31A | 0.4846 | 0.1180 | 0.3901 | 0.066* | |
H31B | 0.5384 | 0.0447 | 0.3332 | 0.066* | |
H31C | 0.4807 | 0.1979 | 0.3171 | 0.066* | |
N41 | 0.75120 (13) | 0.0972 (2) | 0.59603 (9) | 0.0355 (5) | |
N42 | 0.67049 (13) | 0.1362 (2) | 0.55799 (9) | 0.0344 (5) | |
C43 | 0.66437 (16) | 0.0806 (3) | 0.48505 (11) | 0.0335 (6) | |
H43 | 0.6115 | 0.0131 | 0.4751 | 0.040* | |
C44 | 0.74925 (17) | −0.0209 (3) | 0.48690 (12) | 0.0404 (6) | |
H44A | 0.7346 | −0.1326 | 0.4813 | 0.048* | |
H44B | 0.7855 | 0.0110 | 0.4510 | 0.048* | |
C45 | 0.79663 (16) | 0.0117 (3) | 0.55736 (11) | 0.0336 (6) | |
S421 | 0.50684 (4) | 0.25555 (8) | 0.54387 (3) | 0.0477 (2) | |
C422 | 0.60539 (16) | 0.2113 (3) | 0.58829 (12) | 0.0361 (6) | |
N423 | 0.62484 (18) | 0.2475 (3) | 0.65504 (11) | 0.0512 (7) | |
H42A | 0.585 (2) | 0.293 (3) | 0.6745 (14) | 0.061* | |
H42B | 0.675 (2) | 0.220 (3) | 0.6753 (14) | 0.061* | |
S451 | 0.93613 (5) | −0.02351 (9) | 0.66256 (4) | 0.0493 (3) | 0.951 (3) |
C452 | 0.88401 (16) | −0.0510 (3) | 0.58006 (12) | 0.0365 (6) | 0.951 (3) |
C453 | 0.9356 (3) | −0.1417 (6) | 0.5435 (2) | 0.0475 (9) | 0.951 (3) |
H453 | 0.9188 | −0.1700 | 0.4977 | 0.057* | 0.951 (3) |
C454 | 1.0167 (2) | −0.1900 (7) | 0.5800 (2) | 0.0524 (14) | 0.951 (3) |
H454 | 1.0593 | −0.2517 | 0.5612 | 0.063* | 0.951 (3) |
C455 | 1.0251 (2) | −0.1363 (4) | 0.64507 (18) | 0.0537 (12) | 0.951 (3) |
H455 | 1.0740 | −0.1580 | 0.6772 | 0.064* | 0.951 (3) |
S551 | 0.937 (2) | −0.159 (4) | 0.5215 (11) | 0.0475 (9) | 0.049 (3) |
C552 | 0.88401 (16) | −0.0510 (3) | 0.58006 (12) | 0.0365 (6) | 0.049 (3) |
C553 | 0.944 (2) | −0.005 (7) | 0.633 (2) | 0.0493 (3) | 0.049 (3) |
H553 | 0.9341 | 0.0767 | 0.6631 | 0.059* | 0.049 (3) |
C554 | 1.024 (3) | −0.094 (11) | 0.637 (3) | 0.0537 (12) | 0.049 (3) |
H554 | 1.0649 | −0.1006 | 0.6763 | 0.064* | 0.049 (3) |
C555 | 1.032 (4) | −0.169 (16) | 0.577 (4) | 0.0524 (14) | 0.049 (3) |
H555 | 1.0839 | −0.2211 | 0.5676 | 0.063* | 0.049 (3) |
O51 | 0.79155 (10) | 0.37875 (17) | 0.47791 (7) | 0.0338 (4) | |
C51 | 0.77558 (16) | 0.4711 (3) | 0.53498 (11) | 0.0326 (6) | |
C52 | 0.84468 (16) | 0.4851 (3) | 0.58742 (12) | 0.0366 (6) | |
Cl52 | 0.94533 (5) | 0.39239 (9) | 0.58023 (4) | 0.0618 (2) | |
C53 | 0.83348 (19) | 0.5733 (3) | 0.64567 (13) | 0.0464 (7) | |
H53 | 0.8799 | 0.5827 | 0.6811 | 0.056* | |
C54 | 0.7533 (2) | 0.6467 (3) | 0.65044 (13) | 0.0453 (7) | |
Cl54 | 0.73886 (6) | 0.75872 (9) | 0.72375 (4) | 0.0733 (3) | |
C55 | 0.68368 (19) | 0.6329 (3) | 0.59891 (14) | 0.0496 (7) | |
H55 | 0.6294 | 0.6826 | 0.6032 | 0.060* | |
C56 | 0.69494 (17) | 0.5446 (3) | 0.54082 (13) | 0.0424 (6) | |
H56 | 0.6482 | 0.5348 | 0.5057 | 0.051* | |
O61 | 0.5000 | 0.5746 (3) | 0.2500 | 0.0605 (9) | |
H61 | 0.532 (2) | 0.511 (3) | 0.2784 (15) | 0.091* |
U11 | U22 | U33 | U12 | U13 | U23 | |
N1 | 0.0301 (11) | 0.0402 (12) | 0.0312 (11) | −0.0022 (9) | −0.0028 (9) | 0.0066 (9) |
N2 | 0.0304 (12) | 0.0441 (12) | 0.0306 (11) | −0.0018 (10) | −0.0039 (9) | 0.0035 (9) |
C3 | 0.0300 (13) | 0.0390 (14) | 0.0263 (12) | 0.0011 (11) | 0.0029 (10) | −0.0019 (11) |
C4 | 0.0306 (13) | 0.0325 (13) | 0.0254 (12) | 0.0022 (11) | 0.0013 (10) | 0.0006 (10) |
C5 | 0.0259 (13) | 0.0372 (14) | 0.0280 (12) | 0.0040 (11) | −0.0024 (10) | −0.0010 (11) |
C11 | 0.0334 (14) | 0.0411 (15) | 0.0309 (13) | −0.0047 (12) | 0.0001 (11) | 0.0056 (11) |
C12 | 0.0372 (17) | 0.0615 (19) | 0.082 (2) | 0.0038 (15) | 0.0074 (16) | 0.0298 (17) |
C13 | 0.0392 (18) | 0.087 (2) | 0.098 (3) | −0.0103 (18) | 0.0100 (18) | 0.039 (2) |
C14 | 0.058 (2) | 0.0583 (19) | 0.0562 (18) | −0.0216 (17) | −0.0028 (16) | 0.0207 (15) |
C15 | 0.0563 (19) | 0.0407 (16) | 0.0432 (15) | −0.0018 (14) | 0.0001 (14) | 0.0049 (13) |
C16 | 0.0383 (15) | 0.0438 (15) | 0.0332 (14) | −0.0012 (12) | 0.0046 (12) | −0.0012 (12) |
C31 | 0.0385 (15) | 0.0491 (16) | 0.0421 (15) | −0.0018 (13) | −0.0030 (12) | −0.0019 (12) |
N41 | 0.0348 (12) | 0.0398 (12) | 0.0314 (11) | 0.0032 (10) | 0.0015 (9) | 0.0036 (9) |
N42 | 0.0341 (12) | 0.0424 (12) | 0.0264 (10) | 0.0080 (10) | 0.0017 (9) | 0.0004 (9) |
C43 | 0.0367 (14) | 0.0345 (13) | 0.0286 (12) | −0.0024 (11) | 0.0009 (11) | −0.0001 (11) |
C44 | 0.0496 (16) | 0.0359 (14) | 0.0348 (13) | 0.0073 (13) | 0.0010 (12) | −0.0001 (11) |
C45 | 0.0412 (15) | 0.0284 (13) | 0.0313 (13) | 0.0013 (12) | 0.0047 (12) | 0.0032 (11) |
S421 | 0.0361 (4) | 0.0614 (5) | 0.0457 (4) | 0.0054 (3) | 0.0045 (3) | 0.0036 (3) |
C422 | 0.0382 (15) | 0.0369 (14) | 0.0336 (13) | −0.0021 (12) | 0.0062 (12) | 0.0045 (11) |
N423 | 0.0508 (16) | 0.0714 (17) | 0.0317 (13) | 0.0165 (13) | 0.0051 (11) | −0.0039 (12) |
S451 | 0.0460 (5) | 0.0588 (5) | 0.0412 (5) | 0.0101 (4) | −0.0039 (4) | −0.0069 (4) |
C452 | 0.0382 (15) | 0.0347 (14) | 0.0361 (13) | 0.0032 (12) | 0.0026 (12) | 0.0038 (11) |
C453 | 0.0523 (18) | 0.057 (2) | 0.035 (3) | 0.0135 (15) | 0.009 (2) | 0.000 (2) |
C454 | 0.041 (2) | 0.058 (3) | 0.0590 (19) | 0.013 (2) | 0.0074 (17) | −0.0020 (17) |
C455 | 0.0405 (17) | 0.056 (3) | 0.061 (2) | 0.0099 (16) | −0.0100 (15) | 0.0011 (18) |
S551 | 0.0523 (18) | 0.057 (2) | 0.035 (3) | 0.0135 (15) | 0.009 (2) | 0.000 (2) |
C552 | 0.0382 (15) | 0.0347 (14) | 0.0361 (13) | 0.0032 (12) | 0.0026 (12) | 0.0038 (11) |
C553 | 0.0460 (5) | 0.0588 (5) | 0.0412 (5) | 0.0101 (4) | −0.0039 (4) | −0.0069 (4) |
C554 | 0.0405 (17) | 0.056 (3) | 0.061 (2) | 0.0099 (16) | −0.0100 (15) | 0.0011 (18) |
C555 | 0.041 (2) | 0.058 (3) | 0.0590 (19) | 0.013 (2) | 0.0074 (17) | −0.0020 (17) |
O51 | 0.0261 (9) | 0.0424 (10) | 0.0317 (9) | 0.0033 (7) | −0.0025 (7) | −0.0042 (8) |
C51 | 0.0356 (14) | 0.0287 (13) | 0.0333 (13) | −0.0006 (11) | 0.0031 (11) | 0.0024 (11) |
C52 | 0.0320 (14) | 0.0378 (14) | 0.0392 (14) | 0.0002 (11) | −0.0004 (12) | 0.0004 (12) |
Cl52 | 0.0389 (4) | 0.0757 (5) | 0.0665 (5) | 0.0146 (4) | −0.0133 (4) | −0.0190 (4) |
C53 | 0.0496 (18) | 0.0501 (17) | 0.0385 (15) | −0.0095 (14) | 0.0007 (13) | −0.0065 (13) |
C54 | 0.0579 (19) | 0.0391 (15) | 0.0411 (15) | −0.0095 (14) | 0.0155 (14) | −0.0061 (12) |
Cl54 | 0.0881 (6) | 0.0778 (6) | 0.0589 (5) | −0.0104 (5) | 0.0293 (4) | −0.0278 (4) |
C55 | 0.0437 (17) | 0.0510 (17) | 0.0564 (18) | 0.0062 (13) | 0.0157 (15) | −0.0078 (14) |
C56 | 0.0352 (15) | 0.0455 (16) | 0.0454 (15) | 0.0029 (12) | −0.0004 (13) | −0.0032 (13) |
O61 | 0.064 (2) | 0.0498 (18) | 0.0594 (19) | 0.000 | −0.0293 (15) | 0.000 |
N1—C5 | 1.354 (3) | C45—C452 | 1.440 (3) |
N1—N2 | 1.368 (2) | S421—C422 | 1.675 (2) |
N1—C11 | 1.427 (3) | C422—N423 | 1.336 (3) |
N2—C3 | 1.332 (3) | N423—H42A | 0.83 (3) |
C3—C4 | 1.411 (3) | N423—H42B | 0.84 (3) |
C3—C31 | 1.488 (3) | S451—C455 | 1.705 (3) |
C4—C5 | 1.363 (3) | S451—C452 | 1.725 (2) |
C4—C43 | 1.500 (3) | C452—C453 | 1.347 (5) |
C5—O51 | 1.373 (2) | C453—C454 | 1.404 (5) |
C11—C12 | 1.372 (3) | C453—H453 | 0.9300 |
C11—C16 | 1.378 (3) | C454—C455 | 1.339 (4) |
C12—C13 | 1.385 (4) | C454—H454 | 0.9300 |
C12—H12 | 0.9300 | C455—H455 | 0.9300 |
C13—C14 | 1.375 (4) | S551—C555 | 1.707 (11) |
C13—H13 | 0.9300 | C553—C554 | 1.407 (11) |
C14—C15 | 1.352 (4) | C553—H553 | 0.9300 |
C14—H14 | 0.9300 | C554—C555 | 1.342 (10) |
C15—C16 | 1.382 (3) | C554—H554 | 0.9300 |
C15—H15 | 0.9300 | C555—H555 | 0.9300 |
C16—H16 | 0.9300 | O51—C51 | 1.399 (3) |
C31—H31A | 0.9600 | C51—C56 | 1.377 (3) |
C31—H31B | 0.9600 | C51—C52 | 1.380 (3) |
C31—H31C | 0.9600 | C52—C53 | 1.382 (3) |
N41—C45 | 1.290 (3) | C52—Cl52 | 1.722 (2) |
N41—N42 | 1.391 (2) | C53—C54 | 1.366 (4) |
N42—C422 | 1.354 (3) | C53—H53 | 0.9300 |
N42—C43 | 1.489 (3) | C54—C55 | 1.374 (4) |
C43—C44 | 1.534 (3) | C54—Cl54 | 1.745 (3) |
C43—H43 | 0.9800 | C55—C56 | 1.379 (3) |
C44—C45 | 1.501 (3) | C55—H55 | 0.9300 |
C44—H44A | 0.9700 | C56—H56 | 0.9300 |
C44—H44B | 0.9700 | O61—H61 | 0.88 (3) |
C5—N1—N2 | 109.89 (18) | C43—C44—H44B | 111.1 |
C5—N1—C11 | 129.69 (19) | H44A—C44—H44B | 109.1 |
N2—N1—C11 | 120.32 (17) | N41—C45—C452 | 123.3 (2) |
C3—N2—N1 | 105.50 (17) | N41—C45—C44 | 114.0 (2) |
N2—C3—C4 | 111.5 (2) | C452—C45—C44 | 122.7 (2) |
N2—C3—C31 | 120.6 (2) | N423—C422—N42 | 116.0 (2) |
C4—C3—C31 | 127.9 (2) | N423—C422—S421 | 122.6 (2) |
C5—C4—C3 | 103.90 (19) | N42—C422—S421 | 121.36 (18) |
C5—C4—C43 | 128.0 (2) | C422—N423—H42A | 117.2 (19) |
C3—C4—C43 | 128.1 (2) | C422—N423—H42B | 118.9 (19) |
N1—C5—C4 | 109.20 (19) | H42A—N423—H42B | 124 (3) |
N1—C5—O51 | 120.9 (2) | C455—S451—C452 | 91.49 (14) |
C4—C5—O51 | 129.8 (2) | C453—C452—C45 | 127.2 (3) |
C12—C11—C16 | 120.6 (2) | C453—C452—S451 | 109.8 (2) |
C12—C11—N1 | 120.3 (2) | C45—C452—S451 | 122.94 (19) |
C16—C11—N1 | 119.1 (2) | C452—C453—C454 | 114.6 (3) |
C11—C12—C13 | 119.5 (3) | C452—C453—H453 | 122.7 |
C11—C12—H12 | 120.3 | C454—C453—H453 | 122.7 |
C13—C12—H12 | 120.3 | C455—C454—C453 | 111.6 (3) |
C14—C13—C12 | 119.7 (3) | C455—C454—H454 | 124.2 |
C14—C13—H13 | 120.1 | C453—C454—H454 | 124.2 |
C12—C13—H13 | 120.1 | C454—C455—S451 | 112.5 (2) |
C15—C14—C13 | 120.5 (3) | C454—C455—H455 | 123.7 |
C15—C14—H14 | 119.8 | S451—C455—H455 | 123.7 |
C13—C14—H14 | 119.8 | C554—C553—H553 | 123.6 |
C14—C15—C16 | 120.7 (3) | C555—C554—C553 | 111.1 (15) |
C14—C15—H15 | 119.6 | C555—C554—H554 | 124.5 |
C16—C15—H15 | 119.6 | C553—C554—H554 | 124.5 |
C11—C16—C15 | 119.0 (2) | C554—C555—S551 | 112.1 (11) |
C11—C16—H16 | 120.5 | C554—C555—H555 | 123.9 |
C15—C16—H16 | 120.5 | S551—C555—H555 | 123.9 |
C3—C31—H31A | 109.5 | C5—O51—C51 | 115.94 (17) |
C3—C31—H31B | 109.5 | C56—C51—C52 | 120.0 (2) |
H31A—C31—H31B | 109.5 | C56—C51—O51 | 123.0 (2) |
C3—C31—H31C | 109.5 | C52—C51—O51 | 117.0 (2) |
H31A—C31—H31C | 109.5 | C51—C52—C53 | 120.2 (2) |
H31B—C31—H31C | 109.5 | C51—C52—Cl52 | 119.92 (18) |
C45—N41—N42 | 107.92 (18) | C53—C52—Cl52 | 119.83 (19) |
C422—N42—N41 | 120.58 (18) | C54—C53—C52 | 119.1 (2) |
C422—N42—C43 | 126.17 (19) | C54—C53—H53 | 120.4 |
N41—N42—C43 | 113.19 (18) | C52—C53—H53 | 120.4 |
N42—C43—C4 | 112.72 (18) | C53—C54—C55 | 121.3 (2) |
N42—C43—C44 | 100.84 (17) | C53—C54—Cl54 | 119.3 (2) |
C4—C43—C44 | 114.06 (19) | C55—C54—Cl54 | 119.3 (2) |
N42—C43—H43 | 109.6 | C54—C55—C56 | 119.5 (2) |
C4—C43—H43 | 109.6 | C54—C55—H55 | 120.2 |
C44—C43—H43 | 109.6 | C56—C55—H55 | 120.2 |
C45—C44—C43 | 103.32 (18) | C51—C56—C55 | 119.9 (2) |
C45—C44—H44A | 111.1 | C51—C56—H56 | 120.1 |
C43—C44—H44A | 111.1 | C55—C56—H56 | 120.1 |
C45—C44—H44B | 111.1 | ||
C5—N1—N2—C3 | 0.0 (2) | C4—C43—C44—C45 | 113.3 (2) |
C11—N1—N2—C3 | 176.76 (19) | N42—N41—C45—C452 | −179.7 (2) |
N1—N2—C3—C4 | 0.3 (2) | N42—N41—C45—C44 | −1.3 (3) |
N1—N2—C3—C31 | −179.6 (2) | C43—C44—C45—N41 | 6.2 (3) |
N2—C3—C4—C5 | −0.5 (2) | C43—C44—C45—C452 | −175.4 (2) |
C31—C3—C4—C5 | 179.4 (2) | N41—N42—C422—N423 | 1.5 (3) |
N2—C3—C4—C43 | 178.8 (2) | C43—N42—C422—N423 | 178.6 (2) |
C31—C3—C4—C43 | −1.4 (4) | N41—N42—C422—S421 | −178.60 (16) |
N2—N1—C5—C4 | −0.3 (3) | C43—N42—C422—S421 | −1.5 (3) |
C11—N1—C5—C4 | −176.7 (2) | N41—C45—C452—C453 | 179.5 (4) |
N2—N1—C5—O51 | −178.18 (18) | C44—C45—C452—C453 | 1.3 (5) |
C11—N1—C5—O51 | 5.4 (3) | N41—C45—C452—S451 | 2.1 (3) |
C3—C4—C5—N1 | 0.4 (2) | C44—C45—C452—S451 | −176.17 (18) |
C43—C4—C5—N1 | −178.8 (2) | C455—S451—C452—C453 | −0.4 (3) |
C3—C4—C5—O51 | 178.1 (2) | C455—S451—C452—C45 | 177.4 (2) |
C43—C4—C5—O51 | −1.1 (4) | C45—C452—C453—C454 | −177.9 (4) |
C5—N1—C11—C12 | 50.0 (3) | S451—C452—C453—C454 | −0.2 (6) |
N2—N1—C11—C12 | −126.0 (3) | C452—C453—C454—C455 | 0.9 (7) |
C5—N1—C11—C16 | −132.9 (2) | C453—C454—C455—S451 | −1.2 (6) |
N2—N1—C11—C16 | 51.0 (3) | C452—S451—C455—C454 | 0.9 (4) |
C16—C11—C12—C13 | −1.6 (4) | C553—C554—C555—S551 | −10 (12) |
N1—C11—C12—C13 | 175.4 (2) | N1—C5—O51—C51 | 89.3 (2) |
C11—C12—C13—C14 | 0.3 (5) | C4—C5—O51—C51 | −88.1 (3) |
C12—C13—C14—C15 | 1.0 (5) | C5—O51—C51—C56 | −11.5 (3) |
C13—C14—C15—C16 | −1.0 (4) | C5—O51—C51—C52 | 167.5 (2) |
C12—C11—C16—C15 | 1.6 (4) | C56—C51—C52—C53 | −0.4 (3) |
N1—C11—C16—C15 | −175.40 (19) | O51—C51—C52—C53 | −179.4 (2) |
C14—C15—C16—C11 | −0.3 (4) | C56—C51—C52—Cl52 | 179.72 (18) |
C45—N41—N42—C422 | 172.8 (2) | O51—C51—C52—Cl52 | 0.7 (3) |
C45—N41—N42—C43 | −4.6 (2) | C51—C52—C53—C54 | −0.2 (4) |
C422—N42—C43—C4 | 68.7 (3) | Cl52—C52—C53—C54 | 179.7 (2) |
N41—N42—C43—C4 | −114.0 (2) | C52—C53—C54—C55 | 0.7 (4) |
C422—N42—C43—C44 | −169.3 (2) | C52—C53—C54—Cl54 | −179.85 (18) |
N41—N42—C43—C44 | 8.0 (2) | C53—C54—C55—C56 | −0.7 (4) |
C5—C4—C43—N42 | 52.6 (3) | Cl54—C54—C55—C56 | 179.89 (19) |
C3—C4—C43—N42 | −126.5 (2) | C52—C51—C56—C55 | 0.4 (4) |
C5—C4—C43—C44 | −61.7 (3) | O51—C51—C56—C55 | 179.4 (2) |
C3—C4—C43—C44 | 119.3 (3) | C54—C55—C56—C51 | 0.1 (4) |
N42—C43—C44—C45 | −7.8 (2) |
D—H···A | D—H | H···A | D···A | D—H···A |
O61—H61···N2 | 0.88 (3) | 2.03 (3) | 2.900 (2) | 176 (2) |
N423—H42A···O61i | 0.84 (3) | 2.33 (3) | 3.154 (3) | 167 (3) |
N423—H42B···N41 | 0.85 (3) | 2.27 (3) | 2.648 (3) | 107 (2) |
Symmetry code: (i) −x+1, −y+1, −z+1. |
C31H27N5O4S2 | Z = 2 |
Mr = 597.69 | F(000) = 624 |
Triclinic, P1 | Dx = 1.331 Mg m−3 |
a = 10.783 (2) Å | Mo Kα radiation, λ = 0.71073 Å |
b = 11.683 (3) Å | Cell parameters from 6462 reflections |
c = 13.577 (3) Å | θ = 2.5–28.2° |
α = 93.54 (2)° | µ = 0.22 mm−1 |
β = 105.17 (2)° | T = 296 K |
γ = 113.20 (2)° | Needle, yellow |
V = 1490.9 (6) Å3 | 0.48 × 0.12 × 0.06 mm |
Oxford Diffraction Xcalibur with Sapphire CCD detector diffractometer | 5561 independent reflections |
Radiation source: Enhance (Mo) X-ray Source | 1730 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.138 |
ω scans | θmax = 25.6°, θmin = 2.5° |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009) | h = −7→13 |
Tmin = 0.849, Tmax = 0.987 | k = −14→12 |
10433 measured reflections | l = −16→16 |
Refinement on F2 | Primary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.079 | H-atom parameters constrained |
wR(F2) = 0.143 | w = 1/[σ2(Fo2) + (0.0319P)2] where P = (Fo2 + 2Fc2)/3 |
S = 0.88 | (Δ/σ)max < 0.001 |
5561 reflections | Δρmax = 0.26 e Å−3 |
395 parameters | Δρmin = −0.24 e Å−3 |
10 restraints |
Experimental. CrysAlis RED, Oxford Diffraction Ltd., 2009 Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
N1 | 1.0895 (5) | 0.0030 (4) | 0.1894 (3) | 0.0436 (12) | |
N2 | 1.1527 (4) | 0.1065 (4) | 0.1476 (4) | 0.0459 (12) | |
C3 | 1.0468 (6) | 0.1321 (4) | 0.0945 (4) | 0.0430 (15) | |
C4 | 0.9141 (5) | 0.0459 (5) | 0.0992 (4) | 0.0401 (14) | |
C5 | 0.9473 (6) | −0.0321 (5) | 0.1612 (4) | 0.0424 (15) | |
C11 | 1.1772 (6) | −0.0460 (5) | 0.2534 (4) | 0.0420 (14) | |
C12 | 1.1198 (6) | −0.1658 (5) | 0.2763 (5) | 0.0571 (17) | |
H12 | 1.0229 | −0.2171 | 0.2490 | 0.068* | |
C13 | 1.2090 (7) | −0.2083 (5) | 0.3410 (5) | 0.0644 (18) | |
H13 | 1.1707 | −0.2886 | 0.3570 | 0.077* | |
C14 | 1.3536 (7) | −0.1337 (6) | 0.3821 (5) | 0.0657 (18) | |
H14 | 1.4123 | −0.1629 | 0.4256 | 0.079* | |
C15 | 1.4082 (6) | −0.0162 (6) | 0.3573 (5) | 0.0596 (17) | |
H15 | 1.5054 | 0.0343 | 0.3832 | 0.071* | |
C16 | 1.3214 (6) | 0.0286 (5) | 0.2947 (4) | 0.0459 (14) | |
H16 | 1.3602 | 0.1096 | 0.2801 | 0.055* | |
C31 | 1.0776 (5) | 0.2433 (4) | 0.0406 (4) | 0.0609 (17) | |
H31A | 1.0234 | 0.2153 | −0.0317 | 0.091* | |
H31B | 1.1770 | 0.2823 | 0.0477 | 0.091* | |
H31C | 1.0520 | 0.3037 | 0.0711 | 0.091* | |
N41 | 0.5871 (4) | −0.0182 (4) | 0.1331 (3) | 0.0455 (12) | |
N42 | 0.7101 (4) | 0.0797 (4) | 0.1249 (4) | 0.0482 (13) | |
C43 | 0.7718 (6) | 0.0410 (4) | 0.0483 (4) | 0.0487 (16) | |
H43 | 0.7777 | 0.0954 | −0.0040 | 0.058* | |
C44 | 0.6507 (5) | −0.0938 (4) | −0.0010 (4) | 0.0511 (16) | |
H44A | 0.6003 | −0.0969 | −0.0724 | 0.061* | |
H44B | 0.6884 | −0.1568 | 0.0005 | 0.061* | |
C45 | 0.5547 (5) | −0.1162 (5) | 0.0651 (4) | 0.0439 (15) | |
S421 | 0.68139 (15) | 0.21639 (13) | 0.27511 (12) | 0.0544 (5) | |
C422 | 0.7658 (6) | 0.1937 (5) | 0.1848 (5) | 0.0505 (16) | |
N423 | 0.8776 (5) | 0.2867 (4) | 0.1773 (4) | 0.0558 (14) | |
C424 | 0.9084 (6) | 0.3951 (6) | 0.2437 (5) | 0.0622 (18) | |
O424 | 1.0021 (4) | 0.4986 (4) | 0.2506 (3) | 0.0877 (15) | |
C425 | 0.8101 (5) | 0.3718 (5) | 0.3113 (5) | 0.0482 (15) | |
C426 | 0.8307 (6) | 0.4611 (5) | 0.3868 (5) | 0.0636 (18) | |
H426 | 0.9061 | 0.5406 | 0.3996 | 0.076* | |
C427 | 0.7337 (7) | 0.4347 (6) | 0.4514 (5) | 0.0637 (19) | |
O427 | 0.6309 (5) | 0.3363 (4) | 0.4379 (3) | 0.0842 (15) | |
O428 | 0.7767 (4) | 0.5339 (4) | 0.5256 (4) | 0.0852 (14) | |
C428 | 0.6931 (7) | 0.5170 (6) | 0.5969 (6) | 0.094 (2) | |
H48A | 0.7096 | 0.4595 | 0.6416 | 0.112* | |
H48B | 0.5928 | 0.4809 | 0.5580 | 0.112* | |
C429 | 0.7352 (7) | 0.6415 (7) | 0.6602 (6) | 0.119 (3) | |
H49A | 0.6803 | 0.6314 | 0.7071 | 0.179* | |
H49B | 0.7184 | 0.6980 | 0.6155 | 0.179* | |
H49C | 0.8342 | 0.6763 | 0.6992 | 0.179* | |
S451 | 0.3311 (4) | −0.2531 (3) | 0.1357 (3) | 0.0655 (10) | 0.768 (6) |
C452 | 0.4337 (6) | −0.2339 (5) | 0.0544 (4) | 0.0499 (15) | 0.768 (6) |
C453 | 0.398 (3) | −0.339 (2) | −0.0103 (19) | 0.073 (3) | 0.768 (6) |
H453 | 0.4475 | −0.3467 | −0.0552 | 0.087* | 0.768 (6) |
C454 | 0.270 (2) | −0.4427 (17) | −0.002 (2) | 0.075 (5) | 0.768 (6) |
H454 | 0.2228 | −0.5220 | −0.0449 | 0.090* | 0.768 (6) |
C455 | 0.2293 (14) | −0.4072 (9) | 0.0772 (15) | 0.073 (4) | 0.768 (6) |
H455 | 0.1540 | −0.4614 | 0.0971 | 0.087* | 0.768 (6) |
S551 | 0.383 (3) | −0.3635 (19) | −0.0394 (18) | 0.073 (3) | 0.232 (6) |
C552 | 0.4337 (6) | −0.2339 (5) | 0.0544 (4) | 0.0499 (15) | 0.232 (6) |
C553 | 0.349 (5) | −0.251 (4) | 0.112 (4) | 0.0655 (10) | 0.232 (6) |
H553 | 0.3652 | −0.1924 | 0.1690 | 0.079* | 0.232 (6) |
C554 | 0.224 (5) | −0.375 (3) | 0.073 (5) | 0.073 (4) | 0.232 (6) |
H554 | 0.1462 | −0.4003 | 0.0973 | 0.087* | 0.232 (6) |
C555 | 0.239 (9) | −0.446 (5) | −0.002 (8) | 0.075 (5) | 0.232 (6) |
H555 | 0.1772 | −0.5306 | −0.0298 | 0.090* | 0.232 (6) |
O51 | 0.8569 (3) | −0.1355 (3) | 0.1888 (3) | 0.0513 (10) | |
C51 | 0.8251 (6) | −0.1159 (6) | 0.2805 (5) | 0.0543 (16) | |
C52 | 0.7268 (7) | −0.2241 (7) | 0.3002 (6) | 0.073 (2) | |
C53 | 0.6939 (8) | −0.2041 (10) | 0.3902 (8) | 0.116 (3) | |
H53 | 0.6310 | −0.2738 | 0.4086 | 0.140* | |
C54 | 0.7476 (11) | −0.0898 (13) | 0.4529 (8) | 0.132 (4) | |
H54 | 0.7183 | −0.0825 | 0.5107 | 0.158* | |
C55 | 0.8442 (10) | 0.0144 (10) | 0.4315 (6) | 0.105 (3) | |
H55 | 0.8838 | 0.0924 | 0.4756 | 0.125* | |
C56 | 0.8832 (6) | 0.0023 (6) | 0.3421 (5) | 0.0704 (19) | |
H56 | 0.9468 | 0.0725 | 0.3247 | 0.084* | |
C57 | 0.6674 (7) | −0.3502 (6) | 0.2333 (6) | 0.105 (3) | |
H57A | 0.5900 | −0.4086 | 0.2528 | 0.158* | |
H57B | 0.7399 | −0.3803 | 0.2416 | 0.158* | |
H57C | 0.6337 | −0.3435 | 0.1620 | 0.158* |
U11 | U22 | U33 | U12 | U13 | U23 | |
N1 | 0.042 (3) | 0.044 (3) | 0.045 (3) | 0.016 (3) | 0.016 (3) | 0.008 (2) |
N2 | 0.043 (3) | 0.043 (3) | 0.053 (3) | 0.011 (2) | 0.028 (3) | 0.011 (3) |
C3 | 0.047 (4) | 0.041 (3) | 0.046 (4) | 0.017 (3) | 0.025 (3) | 0.007 (3) |
C4 | 0.039 (4) | 0.047 (3) | 0.039 (4) | 0.020 (3) | 0.017 (3) | 0.009 (3) |
C5 | 0.040 (4) | 0.042 (3) | 0.036 (4) | 0.007 (3) | 0.016 (3) | 0.000 (3) |
C11 | 0.040 (4) | 0.045 (3) | 0.037 (4) | 0.016 (3) | 0.011 (3) | 0.001 (3) |
C12 | 0.050 (4) | 0.048 (4) | 0.065 (5) | 0.014 (3) | 0.016 (4) | 0.009 (3) |
C13 | 0.076 (5) | 0.053 (4) | 0.068 (5) | 0.029 (4) | 0.024 (4) | 0.019 (4) |
C14 | 0.062 (5) | 0.075 (4) | 0.058 (5) | 0.032 (4) | 0.010 (4) | 0.015 (4) |
C15 | 0.052 (4) | 0.068 (4) | 0.050 (5) | 0.018 (4) | 0.013 (4) | 0.010 (4) |
C16 | 0.051 (4) | 0.050 (3) | 0.035 (4) | 0.015 (3) | 0.020 (3) | 0.015 (3) |
C31 | 0.068 (4) | 0.051 (3) | 0.067 (5) | 0.019 (3) | 0.034 (4) | 0.019 (3) |
N41 | 0.047 (3) | 0.042 (3) | 0.047 (3) | 0.015 (2) | 0.021 (3) | 0.012 (2) |
N42 | 0.047 (3) | 0.046 (3) | 0.057 (4) | 0.022 (2) | 0.022 (3) | 0.006 (3) |
C43 | 0.057 (4) | 0.051 (3) | 0.043 (4) | 0.021 (3) | 0.027 (3) | 0.003 (3) |
C44 | 0.043 (4) | 0.061 (4) | 0.046 (4) | 0.021 (3) | 0.014 (3) | 0.001 (3) |
C45 | 0.047 (4) | 0.047 (3) | 0.041 (4) | 0.024 (3) | 0.013 (3) | 0.013 (3) |
S421 | 0.0588 (11) | 0.0465 (8) | 0.0573 (12) | 0.0175 (8) | 0.0263 (9) | 0.0045 (8) |
C422 | 0.063 (4) | 0.051 (4) | 0.052 (4) | 0.034 (3) | 0.027 (4) | 0.013 (3) |
N423 | 0.059 (3) | 0.042 (3) | 0.061 (4) | 0.009 (2) | 0.030 (3) | 0.005 (3) |
C424 | 0.061 (5) | 0.055 (4) | 0.058 (5) | 0.014 (4) | 0.018 (4) | 0.007 (4) |
O424 | 0.087 (3) | 0.056 (2) | 0.089 (4) | −0.008 (2) | 0.043 (3) | −0.005 (3) |
C425 | 0.056 (4) | 0.038 (3) | 0.051 (4) | 0.017 (3) | 0.021 (3) | 0.010 (3) |
C426 | 0.074 (5) | 0.053 (4) | 0.064 (5) | 0.020 (3) | 0.035 (4) | 0.001 (4) |
C427 | 0.074 (5) | 0.053 (4) | 0.052 (5) | 0.030 (4) | 0.001 (4) | −0.013 (4) |
O427 | 0.093 (4) | 0.071 (3) | 0.074 (4) | 0.018 (3) | 0.033 (3) | −0.005 (3) |
O428 | 0.101 (4) | 0.074 (3) | 0.075 (4) | 0.030 (3) | 0.036 (3) | −0.011 (3) |
C428 | 0.102 (6) | 0.107 (6) | 0.076 (6) | 0.048 (5) | 0.033 (5) | −0.006 (5) |
C429 | 0.147 (7) | 0.131 (6) | 0.083 (6) | 0.073 (6) | 0.028 (5) | −0.020 (5) |
S451 | 0.0732 (19) | 0.0564 (14) | 0.068 (2) | 0.0167 (12) | 0.0389 (13) | 0.0163 (14) |
C452 | 0.058 (4) | 0.040 (3) | 0.048 (4) | 0.017 (3) | 0.018 (3) | 0.004 (3) |
C453 | 0.085 (6) | 0.043 (7) | 0.053 (11) | 0.002 (5) | 0.007 (7) | −0.003 (5) |
C454 | 0.080 (13) | 0.046 (4) | 0.066 (6) | −0.001 (5) | 0.017 (9) | −0.002 (4) |
C455 | 0.083 (5) | 0.046 (7) | 0.079 (6) | 0.016 (5) | 0.026 (5) | 0.014 (7) |
S551 | 0.085 (6) | 0.043 (7) | 0.053 (11) | 0.002 (5) | 0.007 (7) | −0.003 (5) |
C552 | 0.058 (4) | 0.040 (3) | 0.048 (4) | 0.017 (3) | 0.018 (3) | 0.004 (3) |
C553 | 0.0732 (19) | 0.0564 (14) | 0.068 (2) | 0.0167 (12) | 0.0389 (13) | 0.0163 (14) |
C554 | 0.083 (5) | 0.046 (7) | 0.079 (6) | 0.016 (5) | 0.026 (5) | 0.014 (7) |
C555 | 0.080 (13) | 0.046 (4) | 0.066 (6) | −0.001 (5) | 0.017 (9) | −0.002 (4) |
O51 | 0.049 (2) | 0.056 (2) | 0.048 (3) | 0.0145 (19) | 0.024 (2) | 0.010 (2) |
C51 | 0.058 (4) | 0.075 (4) | 0.042 (5) | 0.037 (4) | 0.020 (4) | 0.020 (4) |
C52 | 0.065 (5) | 0.110 (6) | 0.068 (6) | 0.041 (5) | 0.042 (4) | 0.065 (5) |
C53 | 0.098 (7) | 0.169 (9) | 0.110 (10) | 0.054 (7) | 0.068 (7) | 0.081 (7) |
C54 | 0.140 (10) | 0.248 (15) | 0.078 (8) | 0.125 (10) | 0.068 (7) | 0.074 (9) |
C55 | 0.136 (8) | 0.182 (9) | 0.049 (6) | 0.107 (7) | 0.047 (5) | 0.035 (6) |
C56 | 0.077 (5) | 0.102 (5) | 0.055 (5) | 0.052 (4) | 0.034 (4) | 0.019 (4) |
C57 | 0.092 (6) | 0.082 (5) | 0.129 (7) | 0.013 (4) | 0.041 (5) | 0.070 (5) |
N1—C5 | 1.358 (6) | C426—C427 | 1.489 (8) |
N1—N2 | 1.374 (5) | C426—H426 | 0.9300 |
N1—C11 | 1.426 (6) | C427—O427 | 1.203 (6) |
N2—C3 | 1.333 (6) | C427—O428 | 1.327 (6) |
C3—C4 | 1.409 (6) | O428—C428 | 1.458 (7) |
C3—C31 | 1.497 (6) | C428—C429 | 1.477 (7) |
C4—C5 | 1.364 (7) | C428—H48A | 0.9700 |
C4—C43 | 1.485 (6) | C428—H48B | 0.9700 |
C5—O51 | 1.367 (6) | C429—H49A | 0.9600 |
C11—C16 | 1.382 (6) | C429—H49B | 0.9600 |
C11—C12 | 1.382 (7) | C429—H49C | 0.9600 |
C12—C13 | 1.390 (7) | S451—C455 | 1.699 (9) |
C12—H12 | 0.9300 | S451—C452 | 1.723 (6) |
C13—C14 | 1.384 (7) | C452—C453 | 1.320 (16) |
C13—H13 | 0.9300 | C453—C454 | 1.47 (2) |
C14—C15 | 1.367 (7) | C453—H453 | 0.9300 |
C14—H14 | 0.9300 | C454—C455 | 1.359 (10) |
C15—C16 | 1.377 (7) | C454—H454 | 0.9300 |
C15—H15 | 0.9300 | C455—H455 | 0.9300 |
C16—H16 | 0.9300 | S551—C555 | 1.698 (14) |
C31—H31A | 0.9600 | C553—C554 | 1.48 (2) |
C31—H31B | 0.9600 | C553—H553 | 0.9300 |
C31—H31C | 0.9600 | C554—C555 | 1.359 (13) |
N41—C45 | 1.293 (5) | C554—H554 | 0.9300 |
N41—N42 | 1.405 (5) | C555—H555 | 0.9300 |
N42—C422 | 1.333 (5) | O51—C51 | 1.405 (6) |
N42—C43 | 1.507 (6) | C51—C56 | 1.379 (7) |
C43—C44 | 1.557 (6) | C51—C52 | 1.387 (8) |
C43—H43 | 0.9800 | C52—C53 | 1.390 (10) |
C44—C45 | 1.499 (7) | C52—C57 | 1.481 (8) |
C44—H44A | 0.9700 | C53—C54 | 1.355 (10) |
C44—H44B | 0.9700 | C53—H53 | 0.9300 |
C45—C452 | 1.441 (6) | C54—C55 | 1.362 (11) |
S421—C425 | 1.736 (5) | C54—H54 | 0.9300 |
S421—C422 | 1.771 (5) | C55—C56 | 1.400 (9) |
C422—N423 | 1.300 (6) | C55—H55 | 0.9300 |
N423—C424 | 1.378 (6) | C56—H56 | 0.9300 |
C424—O424 | 1.211 (6) | C57—H57A | 0.9600 |
C424—C425 | 1.534 (7) | C57—H57B | 0.9600 |
C425—C426 | 1.325 (6) | C57—H57C | 0.9600 |
C5—N1—N2 | 109.6 (4) | C424—C425—S421 | 109.7 (4) |
C5—N1—C11 | 131.7 (5) | C425—C426—C427 | 120.3 (5) |
N2—N1—C11 | 118.6 (4) | C425—C426—H426 | 119.9 |
C3—N2—N1 | 105.2 (4) | C427—C426—H426 | 119.9 |
N2—C3—C4 | 112.1 (5) | O427—C427—O428 | 125.0 (7) |
N2—C3—C31 | 120.0 (5) | O427—C427—C426 | 124.2 (6) |
C4—C3—C31 | 127.9 (6) | O428—C427—C426 | 110.7 (6) |
C5—C4—C3 | 103.6 (5) | C427—O428—C428 | 115.7 (5) |
C5—C4—C43 | 128.2 (5) | O428—C428—C429 | 108.9 (6) |
C3—C4—C43 | 128.2 (5) | O428—C428—H48A | 109.9 |
N1—C5—C4 | 109.4 (5) | C429—C428—H48A | 109.9 |
N1—C5—O51 | 122.3 (5) | O428—C428—H48B | 109.9 |
C4—C5—O51 | 128.2 (5) | C429—C428—H48B | 109.9 |
C16—C11—C12 | 119.6 (5) | H48A—C428—H48B | 108.3 |
C16—C11—N1 | 119.3 (5) | C428—C429—H49A | 109.5 |
C12—C11—N1 | 121.1 (5) | C428—C429—H49B | 109.5 |
C11—C12—C13 | 119.0 (5) | H49A—C429—H49B | 109.5 |
C11—C12—H12 | 120.5 | C428—C429—H49C | 109.5 |
C13—C12—H12 | 120.5 | H49A—C429—H49C | 109.5 |
C14—C13—C12 | 121.4 (6) | H49B—C429—H49C | 109.5 |
C14—C13—H13 | 119.3 | C455—S451—C452 | 91.1 (5) |
C12—C13—H13 | 119.3 | C453—C452—C45 | 124.6 (12) |
C15—C14—C13 | 118.5 (6) | C453—C452—S451 | 113.6 (11) |
C15—C14—H14 | 120.7 | C45—C452—S451 | 121.6 (4) |
C13—C14—H14 | 120.7 | C452—C453—C454 | 111.2 (14) |
C14—C15—C16 | 121.0 (6) | C452—C453—H453 | 124.4 |
C14—C15—H15 | 119.5 | C454—C453—H453 | 124.4 |
C16—C15—H15 | 119.5 | C455—C454—C453 | 111.1 (10) |
C15—C16—C11 | 120.4 (5) | C455—C454—H454 | 124.5 |
C15—C16—H16 | 119.8 | C453—C454—H454 | 124.5 |
C11—C16—H16 | 119.8 | C454—C455—S451 | 112.8 (10) |
C3—C31—H31A | 109.5 | C454—C455—H455 | 123.6 |
C3—C31—H31B | 109.5 | S451—C455—H455 | 123.6 |
H31A—C31—H31B | 109.5 | C554—C553—H553 | 124.6 |
C3—C31—H31C | 109.5 | C555—C554—C553 | 111.3 (16) |
H31A—C31—H31C | 109.5 | C555—C554—H554 | 124.4 |
H31B—C31—H31C | 109.5 | C553—C554—H554 | 124.4 |
C45—N41—N42 | 107.5 (4) | C554—C555—S551 | 112.2 (17) |
C422—N42—N41 | 120.5 (4) | C554—C555—H555 | 123.9 |
C422—N42—C43 | 125.3 (4) | S551—C555—H555 | 123.9 |
N41—N42—C43 | 114.2 (4) | C5—O51—C51 | 117.5 (4) |
C4—C43—N42 | 112.5 (4) | C56—C51—C52 | 123.9 (6) |
C4—C43—C44 | 115.7 (4) | C56—C51—O51 | 122.0 (6) |
N42—C43—C44 | 98.8 (4) | C52—C51—O51 | 114.0 (6) |
C4—C43—H43 | 109.8 | C51—C52—C53 | 114.0 (7) |
N42—C43—H43 | 109.8 | C51—C52—C57 | 122.7 (7) |
C44—C43—H43 | 109.8 | C53—C52—C57 | 123.3 (7) |
C45—C44—C43 | 104.6 (4) | C54—C53—C52 | 124.3 (10) |
C45—C44—H44A | 110.8 | C54—C53—H53 | 117.8 |
C43—C44—H44A | 110.8 | C52—C53—H53 | 117.8 |
C45—C44—H44B | 110.8 | C53—C54—C55 | 120.1 (11) |
C43—C44—H44B | 110.8 | C53—C54—H54 | 119.9 |
H44A—C44—H44B | 108.9 | C55—C54—H54 | 119.9 |
N41—C45—C452 | 121.4 (5) | C54—C55—C56 | 119.1 (9) |
N41—C45—C44 | 114.0 (5) | C54—C55—H55 | 120.5 |
C452—C45—C44 | 124.5 (5) | C56—C55—H55 | 120.5 |
C425—S421—C422 | 87.3 (3) | C51—C56—C55 | 118.5 (7) |
N423—C422—N42 | 121.8 (5) | C51—C56—H56 | 120.7 |
N423—C422—S421 | 120.3 (4) | C55—C56—H56 | 120.7 |
N42—C422—S421 | 117.9 (4) | C52—C57—H57A | 109.5 |
C422—N423—C424 | 110.0 (5) | C52—C57—H57B | 109.5 |
O424—C424—N423 | 125.4 (6) | H57A—C57—H57B | 109.5 |
O424—C424—C425 | 122.0 (6) | C52—C57—H57C | 109.5 |
N423—C424—C425 | 112.5 (5) | H57A—C57—H57C | 109.5 |
C426—C425—C424 | 121.8 (5) | H57B—C57—H57C | 109.5 |
C426—C425—S421 | 128.4 (5) | ||
C5—N1—N2—C3 | −0.1 (5) | C43—N42—C422—S421 | −176.4 (4) |
C11—N1—N2—C3 | −178.6 (4) | C425—S421—C422—N423 | −0.2 (5) |
N1—N2—C3—C4 | −1.0 (5) | C425—S421—C422—N42 | −179.4 (4) |
N1—N2—C3—C31 | 178.2 (4) | N42—C422—N423—C424 | 176.8 (5) |
N2—C3—C4—C5 | 1.6 (5) | S421—C422—N423—C424 | −2.4 (7) |
C31—C3—C4—C5 | −177.5 (5) | C422—N423—C424—O424 | −176.2 (6) |
N2—C3—C4—C43 | −178.3 (4) | C422—N423—C424—C425 | 4.1 (7) |
C31—C3—C4—C43 | 2.7 (8) | O424—C424—C425—C426 | −6.1 (9) |
N2—N1—C5—C4 | 1.1 (5) | N423—C424—C425—C426 | 173.5 (5) |
C11—N1—C5—C4 | 179.4 (4) | O424—C424—C425—S421 | 176.0 (5) |
N2—N1—C5—O51 | 177.6 (4) | N423—C424—C425—S421 | −4.3 (6) |
C11—N1—C5—O51 | −4.2 (7) | C422—S421—C425—C426 | −175.3 (6) |
C3—C4—C5—N1 | −1.6 (5) | C422—S421—C425—C424 | 2.4 (4) |
C43—C4—C5—N1 | 178.3 (4) | C424—C425—C426—C427 | −179.5 (6) |
C3—C4—C5—O51 | −177.8 (5) | S421—C425—C426—C427 | −2.0 (8) |
C43—C4—C5—O51 | 2.1 (8) | C425—C426—C427—O427 | −2.8 (10) |
C5—N1—C11—C16 | −160.7 (5) | C425—C426—C427—O428 | 176.9 (5) |
N2—N1—C11—C16 | 17.5 (6) | O427—C427—O428—C428 | 2.3 (9) |
C5—N1—C11—C12 | 18.0 (7) | C426—C427—O428—C428 | −177.4 (5) |
N2—N1—C11—C12 | −163.8 (4) | C427—O428—C428—C429 | −168.6 (5) |
C16—C11—C12—C13 | 0.2 (8) | N41—C45—C452—C453 | −177.0 (19) |
N1—C11—C12—C13 | −178.5 (4) | C44—C45—C452—C453 | 5 (2) |
C11—C12—C13—C14 | −0.4 (8) | N41—C45—C452—S451 | −3.3 (7) |
C12—C13—C14—C15 | −0.3 (9) | C44—C45—C452—S451 | 178.4 (5) |
C13—C14—C15—C16 | 1.3 (9) | C455—S451—C452—C453 | −2.9 (18) |
C14—C15—C16—C11 | −1.6 (8) | C455—S451—C452—C45 | −177.2 (8) |
C12—C11—C16—C15 | 0.8 (7) | C45—C452—C453—C454 | 180 (2) |
N1—C11—C16—C15 | 179.5 (5) | S451—C452—C453—C454 | 5 (3) |
C45—N41—N42—C422 | 178.4 (5) | C452—C453—C454—C455 | −6 (4) |
C45—N41—N42—C43 | −4.1 (6) | C453—C454—C455—S451 | 4 (4) |
C5—C4—C43—N42 | 70.7 (6) | C452—S451—C455—C454 | −1 (2) |
C3—C4—C43—N42 | −109.5 (6) | C553—C554—C555—S551 | −8 (12) |
C5—C4—C43—C44 | −41.9 (7) | N1—C5—O51—C51 | 92.8 (5) |
C3—C4—C43—C44 | 138.0 (5) | C4—C5—O51—C51 | −91.4 (6) |
C422—N42—C43—C4 | 62.7 (6) | C5—O51—C51—C56 | −0.8 (7) |
N41—N42—C43—C4 | −114.6 (5) | C5—O51—C51—C52 | 176.7 (5) |
C422—N42—C43—C44 | −174.7 (5) | C56—C51—C52—C53 | −1.7 (9) |
N41—N42—C43—C44 | 8.0 (5) | O51—C51—C52—C53 | −179.1 (5) |
C4—C43—C44—C45 | 111.9 (5) | C56—C51—C52—C57 | −179.3 (6) |
N42—C43—C44—C45 | −8.3 (5) | O51—C51—C52—C57 | 3.3 (8) |
N42—N41—C45—C452 | 179.2 (5) | C51—C52—C53—C54 | 2.1 (12) |
N42—N41—C45—C44 | −2.3 (6) | C57—C52—C53—C54 | 179.6 (8) |
C43—C44—C45—N41 | 7.3 (6) | C52—C53—C54—C55 | −2.4 (15) |
C43—C44—C45—C452 | −174.3 (5) | C53—C54—C55—C56 | 2.2 (14) |
N41—N42—C422—N423 | −178.4 (5) | C52—C51—C56—C55 | 1.7 (9) |
C43—N42—C422—N423 | 4.4 (8) | O51—C51—C56—C55 | 178.9 (5) |
N41—N42—C422—S421 | 0.7 (6) | C54—C55—C56—C51 | −1.9 (11) |
D—H···A | D—H | H···A | D···A | D—H···A |
C13—H13···O424i | 0.93 | 2.49 | 3.200 (7) | 133 |
C54—H54···Cg1ii | 0.93 | 2.91 | 3.714 (12) | 146 |
C553—H553···Cg1iii | 0.93 | 2.92 | 3.76 (5) | 151 |
Symmetry codes: (i) x, y−1, z; (ii) −x+2, −y, −z+1; (iii) x−1, y, z. |
C32H22BrCl2N5OS2 | Z = 2 |
Mr = 707.47 | F(000) = 716 |
Triclinic, P1 | Dx = 1.517 Mg m−3 |
a = 12.3200 (9) Å | Mo Kα radiation, λ = 0.71073 Å |
b = 12.5700 (9) Å | Cell parameters from 6664 reflections |
c = 12.7742 (9) Å | θ = 2.6–27.8° |
α = 117.202 (8)° | µ = 1.67 mm−1 |
β = 102.879 (7)° | T = 296 K |
γ = 105.727 (7)° | Plate, yellow |
V = 1548.4 (2) Å3 | 0.40 × 0.40 × 0.08 mm |
Oxford Diffraction Xcalibur with Sapphire CCD detector diffractometer | 5773 independent reflections |
Radiation source: Enhance (Mo) X-ray Source | 3158 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.022 |
ω scans | θmax = 25.6°, θmin = 2.6° |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009) | h = −13→14 |
Tmin = 0.779, Tmax = 0.875 | k = −15→10 |
10549 measured reflections | l = −10→15 |
Refinement on F2 | Primary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.039 | H-atom parameters constrained |
wR(F2) = 0.095 | w = 1/[σ2(Fo2) + (0.0475P)2] where P = (Fo2 + 2Fc2)/3 |
S = 0.93 | (Δ/σ)max < 0.001 |
5773 reflections | Δρmax = 0.47 e Å−3 |
402 parameters | Δρmin = −0.34 e Å−3 |
10 restraints |
Experimental. CrysAlis RED, Oxford Diffraction Ltd., 2009 Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
N1 | 0.5457 (2) | 0.3735 (2) | 0.86216 (19) | 0.0478 (5) | |
N2 | 0.4327 (2) | 0.3754 (2) | 0.8277 (2) | 0.0514 (6) | |
C3 | 0.4368 (3) | 0.4319 (2) | 0.7616 (2) | 0.0495 (7) | |
C4 | 0.5508 (3) | 0.4674 (2) | 0.7522 (2) | 0.0477 (7) | |
C5 | 0.6162 (2) | 0.4278 (2) | 0.8157 (2) | 0.0446 (6) | |
C11 | 0.5693 (3) | 0.3119 (2) | 0.9294 (2) | 0.0449 (6) | |
C12 | 0.6877 (3) | 0.3383 (3) | 0.9963 (3) | 0.0552 (7) | |
H12 | 0.7546 | 0.3982 | 0.9997 | 0.066* | |
C13 | 0.7064 (3) | 0.2750 (3) | 1.0586 (3) | 0.0591 (8) | |
H13 | 0.7863 | 0.2915 | 1.1029 | 0.071* | |
C14 | 0.6089 (3) | 0.1887 (3) | 1.0558 (3) | 0.0630 (8) | |
H14 | 0.6221 | 0.1465 | 1.0978 | 0.076* | |
C15 | 0.4917 (3) | 0.1647 (3) | 0.9907 (3) | 0.0719 (9) | |
H15 | 0.4252 | 0.1064 | 0.9893 | 0.086* | |
C16 | 0.4707 (3) | 0.2257 (3) | 0.9271 (3) | 0.0617 (8) | |
H16 | 0.3906 | 0.2088 | 0.8830 | 0.074* | |
C31 | 0.3270 (3) | 0.4476 (3) | 0.7047 (3) | 0.0686 (8) | |
H31A | 0.3053 | 0.4075 | 0.6140 | 0.103* | |
H31B | 0.3464 | 0.5402 | 0.7453 | 0.103* | |
H31C | 0.2589 | 0.4054 | 0.7181 | 0.103* | |
N41 | 0.7375 (3) | 0.5162 (3) | 0.5905 (3) | 0.0661 (7) | |
N42 | 0.6211 (2) | 0.4547 (3) | 0.5794 (2) | 0.0670 (7) | |
C43 | 0.5928 (3) | 0.5358 (3) | 0.6881 (3) | 0.0576 (7) | |
H43 | 0.5288 | 0.5591 | 0.6567 | 0.069* | |
C44 | 0.7168 (3) | 0.6608 (3) | 0.7729 (3) | 0.0672 (8) | |
H44A | 0.7058 | 0.7390 | 0.7866 | 0.081* | |
H44B | 0.7546 | 0.6741 | 0.8558 | 0.081* | |
C45 | 0.7931 (3) | 0.6315 (3) | 0.6965 (3) | 0.0622 (8) | |
S421 | 0.59658 (8) | 0.25102 (9) | 0.35914 (8) | 0.0776 (3) | |
C422 | 0.5442 (3) | 0.3311 (3) | 0.4739 (3) | 0.0576 (8) | |
N423 | 0.4313 (2) | 0.2671 (2) | 0.4522 (2) | 0.0554 (6) | |
C424 | 0.3781 (3) | 0.1417 (3) | 0.3379 (3) | 0.0568 (7) | |
C425 | 0.4545 (3) | 0.1182 (3) | 0.2773 (3) | 0.0724 (9) | |
H425 | 0.4325 | 0.0394 | 0.2004 | 0.087* | |
C441 | 0.2509 (3) | 0.0523 (3) | 0.2964 (3) | 0.0557 (7) | |
C442 | 0.1828 (3) | 0.0877 (3) | 0.3669 (3) | 0.0663 (8) | |
H442 | 0.2188 | 0.1712 | 0.4429 | 0.080* | |
C443 | 0.0635 (3) | 0.0037 (3) | 0.3287 (3) | 0.0738 (9) | |
H443 | 0.0196 | 0.0310 | 0.3783 | 0.089* | |
C444 | 0.0085 (3) | −0.1208 (3) | 0.2172 (3) | 0.0667 (8) | |
Br44 | −0.15403 (3) | −0.23859 (4) | 0.16704 (4) | 0.09399 (17) | |
C445 | 0.0740 (4) | −0.1594 (3) | 0.1453 (3) | 0.0803 (10) | |
H445 | 0.0378 | −0.2435 | 0.0700 | 0.096* | |
C446 | 0.1919 (4) | −0.0751 (3) | 0.1836 (3) | 0.0778 (9) | |
H446 | 0.2349 | −0.1030 | 0.1331 | 0.093* | |
S451 | 0.99714 (13) | 0.68706 (13) | 0.64070 (13) | 0.1055 (6) | 0.947 (4) |
C452 | 0.9177 (3) | 0.7199 (4) | 0.7353 (4) | 0.0739 (9) | 0.947 (4) |
C453 | 0.9844 (6) | 0.8384 (6) | 0.8487 (6) | 0.0934 (17) | 0.947 (4) |
H453 | 0.9561 | 0.8733 | 0.9127 | 0.112* | 0.947 (4) |
C454 | 1.1069 (5) | 0.9043 (5) | 0.8577 (6) | 0.1124 (18) | 0.947 (4) |
H454 | 1.1665 | 0.9865 | 0.9289 | 0.135* | 0.947 (4) |
C455 | 1.1232 (5) | 0.8339 (6) | 0.7532 (7) | 0.1145 (18) | 0.947 (4) |
H455 | 1.1955 | 0.8612 | 0.7421 | 0.137* | 0.947 (4) |
S551 | 1.025 (3) | 0.871 (2) | 0.863 (3) | 0.0934 (17) | 0.053 (4) |
C552 | 0.9177 (3) | 0.7199 (4) | 0.7353 (4) | 0.0739 (9) | 0.053 (4) |
C553 | 0.966 (5) | 0.658 (5) | 0.654 (6) | 0.1055 (6) | 0.053 (4) |
H553 | 0.9264 | 0.5696 | 0.5857 | 0.127* | 0.053 (4) |
C554 | 1.090 (5) | 0.750 (6) | 0.687 (7) | 0.1145 (18) | 0.053 (4) |
H554 | 1.1374 | 0.7270 | 0.6403 | 0.137* | 0.053 (4) |
C555 | 1.126 (7) | 0.868 (8) | 0.790 (10) | 0.1124 (18) | 0.053 (4) |
H555 | 1.1972 | 0.9419 | 0.8192 | 0.135* | 0.053 (4) |
O51 | 0.73172 (16) | 0.43438 (16) | 0.83109 (15) | 0.0493 (4) | |
C51 | 0.7387 (2) | 0.3304 (2) | 0.7303 (2) | 0.0440 (6) | |
C52 | 0.8521 (2) | 0.3502 (3) | 0.7240 (3) | 0.0488 (7) | |
Cl52 | 0.97805 (7) | 0.50033 (8) | 0.83960 (9) | 0.0895 (3) | |
C53 | 0.8662 (3) | 0.2526 (3) | 0.6269 (3) | 0.0586 (8) | |
H53 | 0.9429 | 0.2664 | 0.6230 | 0.070* | |
C54 | 0.7648 (3) | 0.1344 (3) | 0.5356 (3) | 0.0563 (7) | |
Cl54 | 0.77954 (9) | 0.01019 (9) | 0.41070 (8) | 0.0873 (3) | |
C55 | 0.6533 (3) | 0.1136 (3) | 0.5414 (3) | 0.0634 (8) | |
H55 | 0.5856 | 0.0330 | 0.4793 | 0.076* | |
C56 | 0.6397 (3) | 0.2115 (3) | 0.6391 (3) | 0.0576 (7) | |
H56 | 0.5628 | 0.1966 | 0.6428 | 0.069* |
U11 | U22 | U33 | U12 | U13 | U23 | |
N1 | 0.0546 (15) | 0.0491 (13) | 0.0455 (13) | 0.0245 (12) | 0.0228 (11) | 0.0279 (12) |
N2 | 0.0558 (15) | 0.0592 (14) | 0.0494 (14) | 0.0323 (12) | 0.0271 (12) | 0.0304 (12) |
C3 | 0.0627 (19) | 0.0521 (17) | 0.0406 (16) | 0.0336 (15) | 0.0240 (14) | 0.0241 (14) |
C4 | 0.0656 (19) | 0.0472 (16) | 0.0404 (16) | 0.0306 (15) | 0.0266 (14) | 0.0257 (14) |
C5 | 0.0547 (18) | 0.0403 (15) | 0.0406 (15) | 0.0226 (14) | 0.0252 (14) | 0.0198 (13) |
C11 | 0.0557 (18) | 0.0434 (15) | 0.0406 (15) | 0.0250 (14) | 0.0224 (14) | 0.0235 (13) |
C12 | 0.062 (2) | 0.0595 (18) | 0.0545 (17) | 0.0272 (16) | 0.0278 (15) | 0.0363 (16) |
C13 | 0.065 (2) | 0.070 (2) | 0.0525 (18) | 0.0350 (18) | 0.0262 (16) | 0.0367 (17) |
C14 | 0.090 (2) | 0.060 (2) | 0.0539 (19) | 0.0401 (19) | 0.0315 (18) | 0.0366 (16) |
C15 | 0.079 (2) | 0.068 (2) | 0.080 (2) | 0.0250 (19) | 0.0351 (19) | 0.0506 (19) |
C16 | 0.0580 (18) | 0.066 (2) | 0.067 (2) | 0.0224 (17) | 0.0225 (16) | 0.0438 (18) |
C31 | 0.085 (2) | 0.083 (2) | 0.065 (2) | 0.054 (2) | 0.0393 (18) | 0.0460 (18) |
N41 | 0.080 (2) | 0.0741 (19) | 0.0642 (18) | 0.0358 (17) | 0.0382 (16) | 0.0471 (17) |
N42 | 0.0780 (19) | 0.0714 (18) | 0.0550 (17) | 0.0272 (16) | 0.0397 (15) | 0.0343 (15) |
C43 | 0.074 (2) | 0.0604 (19) | 0.0558 (18) | 0.0365 (18) | 0.0330 (17) | 0.0377 (16) |
C44 | 0.089 (2) | 0.0558 (19) | 0.066 (2) | 0.0305 (19) | 0.0310 (19) | 0.0409 (17) |
C45 | 0.078 (2) | 0.071 (2) | 0.068 (2) | 0.039 (2) | 0.036 (2) | 0.054 (2) |
S421 | 0.0958 (7) | 0.0867 (6) | 0.0679 (5) | 0.0459 (6) | 0.0536 (5) | 0.0425 (5) |
C422 | 0.080 (2) | 0.067 (2) | 0.0479 (19) | 0.0399 (19) | 0.0355 (17) | 0.0392 (18) |
N423 | 0.0729 (18) | 0.0614 (16) | 0.0449 (14) | 0.0360 (15) | 0.0317 (13) | 0.0311 (13) |
C424 | 0.080 (2) | 0.062 (2) | 0.0451 (18) | 0.0416 (19) | 0.0316 (17) | 0.0329 (17) |
C425 | 0.095 (2) | 0.072 (2) | 0.059 (2) | 0.044 (2) | 0.0440 (19) | 0.0326 (17) |
C441 | 0.081 (2) | 0.0597 (19) | 0.0423 (17) | 0.0442 (18) | 0.0298 (16) | 0.0295 (15) |
C442 | 0.078 (2) | 0.060 (2) | 0.0572 (19) | 0.041 (2) | 0.0311 (18) | 0.0224 (16) |
C443 | 0.077 (2) | 0.070 (2) | 0.070 (2) | 0.042 (2) | 0.0344 (19) | 0.0274 (19) |
C444 | 0.076 (2) | 0.069 (2) | 0.068 (2) | 0.0457 (19) | 0.0303 (19) | 0.0385 (19) |
Br44 | 0.0795 (3) | 0.0793 (3) | 0.1006 (3) | 0.0331 (2) | 0.0273 (2) | 0.0381 (2) |
C445 | 0.092 (3) | 0.061 (2) | 0.064 (2) | 0.031 (2) | 0.031 (2) | 0.0186 (18) |
C446 | 0.101 (3) | 0.078 (3) | 0.061 (2) | 0.048 (2) | 0.048 (2) | 0.031 (2) |
S451 | 0.0958 (12) | 0.1464 (12) | 0.1214 (10) | 0.0581 (10) | 0.0620 (8) | 0.0961 (9) |
C452 | 0.074 (2) | 0.078 (2) | 0.088 (3) | 0.030 (2) | 0.028 (2) | 0.062 (2) |
C453 | 0.067 (4) | 0.080 (4) | 0.124 (4) | 0.012 (3) | 0.028 (3) | 0.065 (3) |
C454 | 0.076 (4) | 0.112 (4) | 0.155 (5) | 0.026 (3) | 0.034 (3) | 0.091 (4) |
C455 | 0.075 (3) | 0.149 (5) | 0.171 (6) | 0.044 (4) | 0.046 (4) | 0.128 (5) |
S551 | 0.067 (4) | 0.080 (4) | 0.124 (4) | 0.012 (3) | 0.028 (3) | 0.065 (3) |
C552 | 0.074 (2) | 0.078 (2) | 0.088 (3) | 0.030 (2) | 0.028 (2) | 0.062 (2) |
C553 | 0.0958 (12) | 0.1464 (12) | 0.1214 (10) | 0.0581 (10) | 0.0620 (8) | 0.0961 (9) |
C554 | 0.075 (3) | 0.149 (5) | 0.171 (6) | 0.044 (4) | 0.046 (4) | 0.128 (5) |
C555 | 0.076 (4) | 0.112 (4) | 0.155 (5) | 0.026 (3) | 0.034 (3) | 0.091 (4) |
O51 | 0.0512 (12) | 0.0460 (11) | 0.0451 (11) | 0.0196 (9) | 0.0208 (9) | 0.0212 (9) |
C51 | 0.0533 (18) | 0.0436 (16) | 0.0432 (16) | 0.0229 (15) | 0.0241 (14) | 0.0266 (14) |
C52 | 0.0421 (16) | 0.0517 (17) | 0.0502 (17) | 0.0159 (14) | 0.0166 (14) | 0.0299 (15) |
Cl52 | 0.0503 (5) | 0.0766 (6) | 0.0886 (6) | 0.0101 (4) | 0.0132 (4) | 0.0238 (5) |
C53 | 0.0549 (19) | 0.077 (2) | 0.064 (2) | 0.0381 (18) | 0.0339 (17) | 0.0431 (19) |
C54 | 0.073 (2) | 0.062 (2) | 0.0535 (18) | 0.0405 (18) | 0.0372 (17) | 0.0341 (17) |
Cl54 | 0.1139 (7) | 0.0907 (6) | 0.0691 (5) | 0.0620 (6) | 0.0543 (5) | 0.0350 (5) |
C55 | 0.063 (2) | 0.0437 (17) | 0.064 (2) | 0.0156 (15) | 0.0306 (16) | 0.0180 (15) |
C56 | 0.0493 (17) | 0.0473 (18) | 0.068 (2) | 0.0167 (15) | 0.0322 (16) | 0.0242 (16) |
N1—C5 | 1.361 (3) | C425—H425 | 0.9300 |
N1—N2 | 1.374 (3) | C441—C442 | 1.373 (4) |
N1—C11 | 1.428 (3) | C441—C446 | 1.400 (4) |
N2—C3 | 1.330 (3) | C442—C443 | 1.372 (4) |
C3—C4 | 1.404 (3) | C442—H442 | 0.9300 |
C3—C31 | 1.495 (3) | C443—C444 | 1.377 (4) |
C4—C5 | 1.361 (3) | C443—H443 | 0.9300 |
C4—C43 | 1.506 (3) | C444—C445 | 1.366 (4) |
C5—O51 | 1.367 (3) | C444—Br44 | 1.888 (3) |
C11—C12 | 1.375 (3) | C445—C446 | 1.359 (4) |
C11—C16 | 1.375 (3) | C445—H445 | 0.9300 |
C12—C13 | 1.385 (3) | C446—H446 | 0.9300 |
C12—H12 | 0.9300 | S451—C452 | 1.696 (4) |
C13—C14 | 1.364 (4) | S451—C455 | 1.706 (6) |
C13—H13 | 0.9300 | C452—C453 | 1.351 (7) |
C14—C15 | 1.366 (4) | C453—C454 | 1.461 (10) |
C14—H14 | 0.9300 | C453—H453 | 0.9300 |
C15—C16 | 1.379 (4) | C454—C455 | 1.321 (7) |
C15—H15 | 0.9300 | C454—H454 | 0.9300 |
C16—H16 | 0.9300 | C455—H455 | 0.9300 |
C31—H31A | 0.9600 | S551—C555 | 1.707 (12) |
C31—H31B | 0.9600 | C553—C554 | 1.461 (14) |
C31—H31C | 0.9600 | C553—H553 | 0.9300 |
N41—C45 | 1.287 (4) | C554—C555 | 1.322 (12) |
N41—N42 | 1.372 (3) | C554—H554 | 0.9300 |
N42—C422 | 1.359 (4) | C555—H555 | 0.9300 |
N42—C43 | 1.484 (3) | O51—C51 | 1.395 (3) |
C43—C44 | 1.543 (4) | C51—C56 | 1.366 (3) |
C43—H43 | 0.9800 | C51—C52 | 1.379 (3) |
C44—C45 | 1.496 (4) | C52—C53 | 1.377 (4) |
C44—H44A | 0.9700 | C52—Cl52 | 1.730 (3) |
C44—H44B | 0.9700 | C53—C54 | 1.374 (4) |
C45—C452 | 1.439 (4) | C53—H53 | 0.9300 |
S421—C425 | 1.717 (3) | C54—C55 | 1.353 (4) |
S421—C422 | 1.734 (3) | C54—Cl54 | 1.737 (3) |
C422—N423 | 1.295 (3) | C55—C56 | 1.379 (4) |
N423—C424 | 1.399 (3) | C55—H55 | 0.9300 |
C424—C425 | 1.356 (4) | C56—H56 | 0.9300 |
C424—C441 | 1.460 (4) | ||
C5—N1—N2 | 109.84 (19) | C425—C424—C441 | 127.3 (3) |
C5—N1—C11 | 130.5 (2) | N423—C424—C441 | 118.8 (3) |
N2—N1—C11 | 119.5 (2) | C424—C425—S421 | 112.0 (2) |
C3—N2—N1 | 105.3 (2) | C424—C425—H425 | 124.0 |
N2—C3—C4 | 111.7 (2) | S421—C425—H425 | 124.0 |
N2—C3—C31 | 120.5 (2) | C442—C441—C446 | 116.2 (3) |
C4—C3—C31 | 127.7 (2) | C442—C441—C424 | 121.8 (3) |
C5—C4—C3 | 104.5 (2) | C446—C441—C424 | 122.0 (3) |
C5—C4—C43 | 127.4 (3) | C443—C442—C441 | 122.0 (3) |
C3—C4—C43 | 128.1 (2) | C443—C442—H442 | 119.0 |
C4—C5—N1 | 108.7 (2) | C441—C442—H442 | 119.0 |
C4—C5—O51 | 128.6 (2) | C442—C443—C444 | 120.1 (3) |
N1—C5—O51 | 122.7 (2) | C442—C443—H443 | 119.9 |
C12—C11—C16 | 120.1 (2) | C444—C443—H443 | 119.9 |
C12—C11—N1 | 121.3 (2) | C445—C444—C443 | 119.3 (3) |
C16—C11—N1 | 118.6 (2) | C445—C444—Br44 | 120.4 (3) |
C11—C12—C13 | 119.4 (3) | C443—C444—Br44 | 120.3 (3) |
C11—C12—H12 | 120.3 | C446—C445—C444 | 120.1 (3) |
C13—C12—H12 | 120.3 | C446—C445—H445 | 120.0 |
C14—C13—C12 | 120.7 (3) | C444—C445—H445 | 120.0 |
C14—C13—H13 | 119.7 | C445—C446—C441 | 122.3 (3) |
C12—C13—H13 | 119.7 | C445—C446—H446 | 118.9 |
C13—C14—C15 | 119.5 (3) | C441—C446—H446 | 118.9 |
C13—C14—H14 | 120.2 | C452—S451—C455 | 92.0 (3) |
C15—C14—H14 | 120.2 | C453—C452—C45 | 124.7 (4) |
C14—C15—C16 | 120.9 (3) | C453—C452—S451 | 112.1 (3) |
C14—C15—H15 | 119.6 | C45—C452—S451 | 123.2 (3) |
C16—C15—H15 | 119.6 | C452—C453—C454 | 111.1 (6) |
C11—C16—C15 | 119.4 (3) | C452—C453—H453 | 124.4 |
C11—C16—H16 | 120.3 | C454—C453—H453 | 124.4 |
C15—C16—H16 | 120.3 | C455—C454—C453 | 112.2 (5) |
C3—C31—H31A | 109.5 | C455—C454—H454 | 123.9 |
C3—C31—H31B | 109.5 | C453—C454—H454 | 123.9 |
H31A—C31—H31B | 109.5 | C454—C455—S451 | 112.5 (4) |
C3—C31—H31C | 109.5 | C454—C455—H455 | 123.8 |
H31A—C31—H31C | 109.5 | S451—C455—H455 | 123.8 |
H31B—C31—H31C | 109.5 | C554—C553—H553 | 124.5 |
C45—N41—N42 | 108.5 (3) | C555—C554—C553 | 111.9 (12) |
C422—N42—N41 | 119.3 (3) | C555—C554—H554 | 124.0 |
C422—N42—C43 | 126.7 (3) | C553—C554—H554 | 124.0 |
N41—N42—C43 | 114.0 (2) | C554—C555—S551 | 112.0 (15) |
N42—C43—C4 | 113.5 (2) | C554—C555—H555 | 124.0 |
N42—C43—C44 | 100.3 (2) | S551—C555—H555 | 124.0 |
C4—C43—C44 | 115.3 (2) | C5—O51—C51 | 115.95 (19) |
N42—C43—H43 | 109.1 | C56—C51—C52 | 119.1 (2) |
C4—C43—H43 | 109.1 | C56—C51—O51 | 123.4 (2) |
C44—C43—H43 | 109.1 | C52—C51—O51 | 117.5 (2) |
C45—C44—C43 | 103.5 (2) | C53—C52—C51 | 120.9 (3) |
C45—C44—H44A | 111.1 | C53—C52—Cl52 | 119.7 (2) |
C43—C44—H44A | 111.1 | C51—C52—Cl52 | 119.4 (2) |
C45—C44—H44B | 111.1 | C54—C53—C52 | 118.8 (3) |
C43—C44—H44B | 111.1 | C54—C53—H53 | 120.6 |
H44A—C44—H44B | 109.0 | C52—C53—H53 | 120.6 |
N41—C45—C452 | 121.5 (3) | C55—C54—C53 | 120.7 (3) |
N41—C45—C44 | 113.6 (3) | C55—C54—Cl54 | 119.5 (2) |
C452—C45—C44 | 124.8 (3) | C53—C54—Cl54 | 119.8 (2) |
C425—S421—C422 | 87.62 (16) | C54—C55—C56 | 120.3 (3) |
N423—C422—N42 | 123.9 (3) | C54—C55—H55 | 119.8 |
N423—C422—S421 | 116.5 (2) | C56—C55—H55 | 119.8 |
N42—C422—S421 | 119.6 (3) | C51—C56—C55 | 120.1 (3) |
C422—N423—C424 | 109.9 (3) | C51—C56—H56 | 119.9 |
C425—C424—N423 | 113.9 (3) | C55—C56—H56 | 119.9 |
C5—N1—N2—C3 | −0.4 (3) | N42—C422—N423—C424 | −178.4 (2) |
C11—N1—N2—C3 | −176.7 (2) | S421—C422—N423—C424 | 1.8 (3) |
N1—N2—C3—C4 | −0.1 (3) | C422—N423—C424—C425 | −1.0 (3) |
N1—N2—C3—C31 | 178.2 (2) | C422—N423—C424—C441 | 179.2 (2) |
N2—C3—C4—C5 | 0.6 (3) | N423—C424—C425—S421 | −0.1 (3) |
C31—C3—C4—C5 | −177.6 (2) | C441—C424—C425—S421 | 179.6 (2) |
N2—C3—C4—C43 | −178.6 (2) | C422—S421—C425—C424 | 0.9 (2) |
C31—C3—C4—C43 | 3.2 (4) | C425—C424—C441—C442 | 179.8 (3) |
C3—C4—C5—N1 | −0.8 (3) | N423—C424—C441—C442 | −0.5 (4) |
C43—C4—C5—N1 | 178.3 (2) | C425—C424—C441—C446 | 0.8 (4) |
C3—C4—C5—O51 | 177.3 (2) | N423—C424—C441—C446 | −179.5 (2) |
C43—C4—C5—O51 | −3.5 (4) | C446—C441—C442—C443 | −0.5 (4) |
N2—N1—C5—C4 | 0.8 (3) | C424—C441—C442—C443 | −179.6 (3) |
C11—N1—C5—C4 | 176.5 (2) | C441—C442—C443—C444 | 0.5 (5) |
N2—N1—C5—O51 | −177.4 (2) | C442—C443—C444—C445 | −0.1 (5) |
C11—N1—C5—O51 | −1.7 (4) | C442—C443—C444—Br44 | 178.1 (2) |
C5—N1—C11—C12 | 22.9 (4) | C443—C444—C445—C446 | −0.3 (5) |
N2—N1—C11—C12 | −161.7 (2) | Br44—C444—C445—C446 | −178.5 (2) |
C5—N1—C11—C16 | −157.7 (3) | C444—C445—C446—C441 | 0.3 (5) |
N2—N1—C11—C16 | 17.7 (3) | C442—C441—C446—C445 | 0.1 (4) |
C16—C11—C12—C13 | 1.5 (4) | C424—C441—C446—C445 | 179.2 (3) |
N1—C11—C12—C13 | −179.1 (2) | N41—C45—C452—C453 | −175.4 (5) |
C11—C12—C13—C14 | −1.0 (4) | C44—C45—C452—C453 | 3.4 (6) |
C12—C13—C14—C15 | 0.0 (4) | N41—C45—C452—S451 | 5.6 (4) |
C13—C14—C15—C16 | 0.5 (5) | C44—C45—C452—S451 | −175.5 (2) |
C12—C11—C16—C15 | −1.0 (4) | C455—S451—C452—C453 | −0.1 (4) |
N1—C11—C16—C15 | 179.6 (2) | C455—S451—C452—C45 | 179.0 (3) |
C14—C15—C16—C11 | 0.0 (4) | C45—C452—C453—C454 | −179.4 (4) |
C45—N41—N42—C422 | 179.6 (2) | S451—C452—C453—C454 | −0.3 (6) |
C45—N41—N42—C43 | 0.5 (3) | C452—C453—C454—C455 | 0.6 (7) |
C422—N42—C43—C4 | 55.9 (4) | C453—C454—C455—S451 | −0.6 (7) |
N41—N42—C43—C4 | −125.0 (3) | C452—S451—C455—C454 | 0.4 (5) |
C422—N42—C43—C44 | 179.5 (2) | C553—C554—C555—S551 | 8 (16) |
N41—N42—C43—C44 | −1.4 (3) | C4—C5—O51—C51 | −84.1 (3) |
C5—C4—C43—N42 | 63.0 (4) | N1—C5—O51—C51 | 93.9 (3) |
C3—C4—C43—N42 | −118.0 (3) | C5—O51—C51—C56 | −17.9 (3) |
C5—C4—C43—C44 | −51.9 (4) | C5—O51—C51—C52 | 162.1 (2) |
C3—C4—C43—C44 | 127.1 (3) | C56—C51—C52—C53 | 0.5 (4) |
N42—C43—C44—C45 | 1.7 (2) | O51—C51—C52—C53 | −179.5 (2) |
C4—C43—C44—C45 | 124.0 (2) | C56—C51—C52—Cl52 | −179.80 (19) |
N42—N41—C45—C452 | 179.8 (2) | O51—C51—C52—Cl52 | 0.2 (3) |
N42—N41—C45—C44 | 0.8 (3) | C51—C52—C53—C54 | 0.1 (4) |
C43—C44—C45—N41 | −1.7 (3) | Cl52—C52—C53—C54 | −179.63 (19) |
C43—C44—C45—C452 | 179.3 (2) | C52—C53—C54—C55 | −0.5 (4) |
N41—N42—C422—N423 | −177.2 (2) | C52—C53—C54—Cl54 | 179.2 (2) |
C43—N42—C422—N423 | 1.9 (4) | C53—C54—C55—C56 | 0.3 (4) |
N41—N42—C422—S421 | 2.6 (3) | Cl54—C54—C55—C56 | −179.3 (2) |
C43—N42—C422—S421 | −178.31 (19) | C52—C51—C56—C55 | −0.7 (4) |
C425—S421—C422—N423 | −1.6 (2) | O51—C51—C56—C55 | 179.4 (2) |
C425—S421—C422—N42 | 178.6 (2) | C54—C55—C56—C51 | 0.3 (4) |
Cg1 represents the centroid of the C11–C16 ring. |
Compound | D—H···A | D—H | H···A | D···A | D—H···A |
(Ia) | N423—H42A···N2i | 0.92 (3) | 2.28 (3) | 3.111 (3) | 150 (2) |
N423—H42A···N41 | 0.92 (3) | 2.27 (3) | 2.628 (4) | 103 (2) | |
(Ib) | O61—H61···N2 | 0.88 (3) | 2.03 (3) | 2.900 (2) | 176 (2) |
N423—H42A···O61ii | 0.84 (3) | 2.33 (3) | 3.154 (3) | 167 (3) | |
N423—H42B···N41 | 0.85 (3) | 2.27 (3) | 2.648 (3) | 107 (2) | |
(II) | C13—H13···O424iii | 0.93 | 2.49 | 3.200 (7) | 133 |
C54—H54···Cg1iv | 0.93 | 2.91 | 3.714 (12) | 146 | |
C553—H553···Cg1v | 0.93 | 2.92 | 3.76 (5) | 151 |
Symmetry codes: (i) 1 + x, y, z; (ii) 1 - x, 1 - y, 1 - z; (iii) x, -1 + y, z; (iv) 2 - x, -y, 1 - z; (v) -1 + x, y, z. |
Acknowledgements
CHC thanks the University of Mysore for research facilities.
Funding information
HSY thanks the University Grants Commission, New Delhi for the award of a BSR Faculty Fellowship for three years.
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