Figure 4
(a) Stereoview into the galactose-binding site II of the ML-I B-chain. Residues forming the sugar-binding pocket are shown in ball-and-stick representation and coloured blue; galactose is shown in red. Hydrogen bonds are indicated as black dashed lines. Water molecules are shown as blue circles. (b) As in (a) for the galactose-binding site II of ML-I in complex with lactose. Residues involved in hydrogen bonding of lactose and those indirectly stabilizing the complex are shown in blue, lactose is shown in red and the aromatic residue building the top part is in green. The electron density around lactose is coloured dark green. Hydrogen bonds are again shown as black dashed lines. Waters are indicated as blue circles. |