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Figure 3
(a) Surface representation of a single subunit, showing the pocket that accommodates the substrate (magenta) that is augmented by interactions with residues His4 and Arg43 (yellow) from the neighbouring subunit. (b). Stereoview of ligand binding, based on the position of adenosine (stick representation, coloured by atom) in T. thermophilus PNP (Tahirov et al., 2004BB16). The electron density for selected side chains is represented as wire contoured at a level of 1σ. These are (clockwise from bottom of figure) Glu181, Arg87, Thr90, Asp204 and Phe159 in magenta from one subunit (blue). His4 and Arg43 (yellow) from the adjacent subunit (green) complete the active centre (see text).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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