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Figure 6
Location of E213A/D214A mutations at the interdomain interface. The interface between the SBD (green) and NBD (yellow) from the Hsc70ΔCtermE213A/D214A structure is shown with the A213/A214 mutant side chains in black and Asn417 and Arg418 in yellow and blue, respectively. Superimposed on this structure is the Cα trace for the isolated bovine Hsc70 ATPase domain (in blue) with the E213/D214 side chains in red. |