Figure 3
Selected active-site details. Putative hydrogen-bonding interactions (green dashed lines) between papain (sticks coloured C black, O red, N blue, S yellow) and the peptide fragments derived from TbICP (sticks coloured C orange, O red, N blue) are depicted. The OD1, OD2 and OD3 atoms associated with the sulfonic acid group of Cys25 are labelled 1, 2 and 3, respectively; water molecules are shown as red spheres and labelled W. |