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Figure 1
Structure of the active site of HCA II complexed with inhibitors. (a) Acetazolamide (AZM), (b) BB3, (c) TDM; (d) superimposition of all three: BB3, blue; TDM, red; AZM, green. The Zn atom is shown as a black sphere; side chains are as labeled. AZM coordinates were taken from PDB code 1yda (Nair et al., 1995 ). The red Fo − Fc electron-density map shown in (a) and (b) is contoured at 2σ and was calculated without the inhibitors present. Figures were generated and rendered with BobScript and Raster3D, respectively (Esnouf, 1999 ; Merritt & Bacon, 1997 ). |


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