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Figure 1
Folate metabolism and the role of 5-formyl-THF cyclo-ligase. (a) An overview of bacterial folate metabolism (modified from Zittoun & Zittoun, 1972BB26). Both folate and the one-carbon group it carries can exist in different oxidation states, which are interconvertable. The different forms of folate play a role in several important metabolic pathways, including the biosynthesis of purines, methionine and thymidylate. (b) The reaction converting 5-formyl-THF (top) to 5,10-methenyl-THF (bottom) that is catalysed by 5-formyl-THF cyclo-ligase. The metabolically important one-carbon group carried by 5-formyl-THF is highlighted in grey. The catalytically important N5 and N10 positions are labelled.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 63| Part 3| March 2007| Pages 168-172
https://doi.org/10.1107/S1744309107007221
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