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Figure 2
Surface representation of MNEI and bound ions. (a) Electrostatic potential of the concave (left) and convex (right) MNEI surfaces with bound sulfate ions (S1–S4). Positive and negative surface potential is shown in blue and red, respectively. (b) Surface representation of MNEI, highlighting key residues for sweetness (shown in the same orientation as in a). Residues important for putative charge–charge interactions between MNEI and the sweet taste receptor T1R2–T1R3 are shown in green and other key residues for MNEI sweetness are shown in blue and violet (where mutation causes a decrease in sweetness of one and two orders of magnitude, respectively).

ISSN: 2053-230X
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