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Figure 3
(a, b) Orthogonal views of the ribbon structurs of HsaD from M. tuberculosis (PDB code 2vf2, purple) aligned with those of the BphD enzymes from B. xenovorans LB400 (PDB code 2og1, green) and R. jostii RHA1 (PDB code 1c4x, cyan) and of MphC from E. coli (PDB code 1u2e, yellow). (c) A view of the overlay highlighting the region correlating to amino acids 199–232 in M. tuberculosis HsaD. (d) A view highlighting the α-helical lid domain of M. tuberculosis HsaD. The structural alignments were performed by secondary-structure matching (SSM) in CCP4mg (Krissinel & Henrick, 2004 ![]() ![]() |