view article

Figure 1
The reversible ADP-ribosylation reaction. ARTs and PARPs catalyse the transfer of an ADP-ribose moiety from NAD onto specific amino-acid residues or onto ADP-ribose, respectively, thereby releasing nicotinamide. The reverse reaction is catalysed by ARHs or PARGs through the hydrolysis of the α-glycosidic bond between ADP-ribose and the side chain. X can be Arg, Asp, Glu, Asn, Cys, diphthamide or ADP-ribose. For mono-ADP-ribosylation R and R′ are hydroxyl groups, while for poly-ADP-ribosylation ADP-ribose can be attached to the R site (elongation) or to the R′ site (branching).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Follow Acta Cryst. F
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds