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Figure 5
Sequence alignment of ARHs. All three ARH families from M. musculus (mm) and Homo sapiens (hs) were aligned using the program ClustalW (Chenna et al., 2003BB5); the numbering of residues is according to the mARH3 sequence in the crystal structure (2qty ), i.e. without the mitochondrial targeting sequence. Identical residues are shown in red and similar residues are shown in blue. Residues that participate in the coordination of the two Mg2+ ions are underlined. Sequence identities within the family from M. musculus are 16.2% for mARH3 and mARH2, 17.4% for mARH3 and mARH1 and 42.1% for mARH1 and mARH2, while the sequence identity between mARH3 from M. musculus and H. sapiens is 89.7%.

ISSN: 2053-230X
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