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Figure 1
The protein and DNA constructs used in characterization and crystallization. (a) Human HNF4α-DBD protein sequence. The predicted DNA-recognition helix is boxed and the MODY mutations are shown in red. Cloning artifacts from the expression vector are indicated by lower case letters at the N-terminal end. (b) The natural HNF1α promoter sequence (−46 to −66; Gragnoli et al., 1997BB5) containing the HNF4α recognition site used in crystallization and binding studies. Two direct-repeat half-sites are boxed and the MODY mutation is shown in red.

ISSN: 2053-230X
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