The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism

Bakolitsa, C.; Kumar, A.; McMullan, D.; Krishna, S.S.; Miller, M.D.; Carlton, D.; Najmanovich, R.; Abdubek, P.; Astakhova, T.; Chiu, H.-J.; Clayton, T.; Deller, M.C.; Duan, L.; Elias, Y.; Feuerhelm, J.; Grant, J.C.; Grzechnik, S.K.; Han, G.W.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Kozbial, P.; Marciano, D.; Morse, A.T.; Nigoghossian, E.; Okach, L.; Oommachen, S.; Paulsen, J.; Reyes, R.; Rife, C.L.; Trout, C.V.; van den Bedem, H.; Weekes, D.; White, A.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Elsliger, M.-A.; Deacon, A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A.

doi:10.1107/S1744309109022684

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
An acidic pocket conserved in the DUF1089 family suggests a ligand-binding site. The PA1994 monomers, colored white and blue, are shown as a ribbon diagram and as a surface representation. Invariant residues (Asp101, Asp103 and Tyr147) are indicated, with the conserved Asn111 located behind the pocket labeled in parentheses. The ethylene glycol (EDO) and MPD molecules that line the entrance to the acidic pocket in the crystal are shown in green.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 66| Part 10| October 2010| Pages 1211-1217

doi:10.1107/S1744309109022684

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