The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator

Bakolitsa, C.; Bateman, A.; Jin, K.K.; McMullan, D.; Krishna, S.S.; Miller, M.D.; Abdubek, P.; Acosta, C.; Astakhova, T.; Axelrod, H.L.; Burra, P.; Carlton, D.; Chiu, H.-J.; Clayton, T.; Das, D.; Deller, M.C.; Duan, L.; Elias, Y.; Feuerhelm, J.; Grant, J.C.; Grzechnik, A.; Grzechnik, S.K.; Han, G.W.; Jaroszewski, L.; Klock, H.E.; Knuth, M.W.; Kozbial, P.; Kumar, A.; Marciano, D.; Morse, A.T.; Murphy, K.D.; Nigoghossian, E.; Okach, L.; Oommachen, S.; Paulsen, J.; Reyes, R.; Rife, C.L.; Sefcovic, N.; Tien, H.; Trame, C.B.; Trout, C.V.; van den Bedem, H.; Weekes, D.; White, A.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Elsliger, M.-A.; Deacon, A.M.; Godzik, A.; Lesley, S.; Wilson, I.A.

doi:10.1107/S1744309109025196

Acta Crystallographica Section F
Acta Crystallographica
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Figure 2
The C-terminal domain of Jann_2411 forms a zinc finger. (a) Ribbon representation of the Jann_2411 dimer. The zinc-finger domains are depicted in blue, the N-terminal domains are depicted in magenta and green and the zinc ions are shown as gray spheres. The zinc-coordinating cysteines are shown in ball-and-stick representation and labeled. (b) Stereoview of the structural superposition of the C-terminal domain of Jann_2411 (PDB code 3h0n , residues 144–187, gray) and a PHD finger fragment from yeast Yng1 protein (PDB code 2jmi , residues 38–83, blue). Zinc ions are shown as spheres and side chains of coordinating residues are indicated.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 66| Part 10| October 2010| Pages 1198-1204

doi:10.1107/S1744309109025196

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