The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role

Krishna, S.S.; Aravind, L.; Bakolitsa, C.; Caruthers, J.; Carlton, D.; Miller, M.D.; Abdubek, P.; Astakhova, T.; Axelrod, H.L.; Chiu, H.-J.; Clayton, T.; Deller, M.C.; Duan, L.; Feuerhelm, J.; Grant, J.C.; Han, G.W.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Kumar, A.; Marciano, D.; McMullan, D.; Morse, A.T.; Nigoghossian, E.; Okach, L.; Reyes, R.; Rife, C.L.; van den Bedem, H.; Weekes, D.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Elsliger, M.-A.; Deacon, A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A.

doi:10.1107/S1744309110002514

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 2
SSO2064 exhibits structural similarity to protein–protein interaction motifs, rubredoxin-like zinc ribbons and OB folds. (a) Ribbon diagram showing the structural superposition of SSO2064 (PDB code 3irb ; residues 8–144; blue) with the 14-3-3 interacting motif of plant H⁺-ATPase (PDB code 2o98 ; residues 7–56; cyan), a zinc-substituted rubredoxin from Guillardia theta (PDB code 1h7v ; residues 1–60; magenta) and the major cold-shock protein from E. coli (PDB code 1mjc ; residues 1–70; yellow). Superposed proteins have been translated for clarity. Zinc ions are indicated as spheres. (b) Electrostatic surface representation of SSO2064 in the same orientation as in (a). Positive potential is in blue (+7kTe⁻¹) and negative potential is in red (−7kTe⁻¹).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 66| Part 10| March 2010| Pages 1160-1166

doi:10.1107/S1744309110002514

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