Figure 3
(a) Overlay of the crystal structures of a putative ζ-class GST from C. immitis shown in gray with human ζ-class GST in light blue (with glutathione and sulfate ion shown as sticks; Polekhina et al., 2001) and mouse ζ-class GST in dark blue (Mizohata et al., unpublished work). (b) Overlay of the crystal structures of a putative ζ- class GST from C. immitis shown in gray with human π-class GSTP1-1 in pink [with GST and the inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) in stick representation; Federici et al., 2009] and human θ-class GSTT1-1 in dark red (Tars et al., 2006). |