The Protein Maker: an automated system for high-throughput parallel purification

Smith, E.R.; Begley, D.W.; Anderson, V.; Raymond, A.C.; Haffner, T.E.; Robinson, J.I.; Edwards, T.E.; Duncan, N.; Gerdts, C.J.; Mixon, M.B.; Nollert, P.; Staker, B.L.; Stewart, L.J.

doi:10.1107/S1744309111028776

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
The Protein Maker instrument with syringe valves, liquid-handling sample manifold and deep-well plate deck (a). In the depicted configuration, 15 of the 24 syringe valves are at the front, with the remaining nine at the back (not shown). Also depicted is a schematic drawing of the plumbing for each individual nine-port valve (b) and a close-up image of the sample-load and primary purification manifolds with 24 × 1.0 ml purification columns in place (c). All 24 valves are individually lined and independently operated, thus allowing up to 24 sample-uptake lines and purification columns in a single run.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 67| Part 9| August 2011| Pages 1015-1021

doi:10.1107/S1744309111028776

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