Figure 5
Surface renderings of the Br. melitensis (a), Ba. henselae (b), E. coli (c) and human (d) GLXR domains. The conserved disulfide active site is shown in yellow and the HSL loop regions are shown in cyan, magenta, green and gold as in Fig. 4. The V-shaped pocket amenable to drug design in the bacterial GLXRs is indicated by the red chevron. The protein poses are rotated 90° relative to Fig. 4(g). |