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Figure 2
(a) NADP is well defined in the structure of G. lamblia aldose reductase. (b) The adenine ring of NADP stacks hydrophobically with the side chains of His242 and Arg269. While Arg269 is conserved between human and Giardia aldose reductase, His242 of Giardia aldose reductase is an alanine in the human enzyme. This figure was prepared with CCP4mg (McNicholas et al., 2011BB24). In both cases σA-weighted 2|Fo| − |Fc| electron density is shown in blue at 1σ and σA-weighted |Fo| − |Fc| electron density is shown in green and red at ±3σ.

ISSN: 2053-230X
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